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https://www.readbyqxmd.com/read/29905548/cutaneous-polypoid-melanoma-of-head-and-neck
#1
U Wollina, G Hansel, J Schönlebe
Cutaneous polypoid melanoma is an uncommon subtype of malignant melanoma. The clinical behavior of this subtype has been described as aggressive. Tumors can be sessile or pedunculated. The typical patient is a younger adult. Authors have analyzed the case histories of patients with polypoid melanomas of the head and neck region treated at our clinic from 2001 to 2018. We identified 3 female patients with tumors of the neck and cheek. In contrast to other reports, all patients were older than 80-years of age...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29904313/basal-cell-carcinoma-and-malignant-melanoma-cutaneous-collision-tumor
#2
Reid Green, Meghan Woody, Anthony C Soldano, Erin Madden
Malignant tumors composed of both epithelial and melanocytic populations are exceedingly rare. Because the etiology of these malignant tumors is not yet defined, several authors have argued for the continued cataloging of these lesions. We present a 67-year-old man with a suspicious-appearing lesion on the right forearm; initial biopsy was consistent with a pigmented basal cell carcinoma. On re-excision, a collision of malignant melanoma and basal cell was identified.
July 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29899391/heterogeneous-relationships-of-squamous-and-basal-cell-carcinomas-of-the-skin-with-smoking-the-uk-million-women-study-and-meta-analysis-of-prospective-studies
#3
Kirstin Pirie, Valerie Beral, Alicia K Heath, Jane Green, Gillian K Reeves, Richard Peto, Penelope McBride, Catherine M Olsen, Adèle C Green
INTRODUCTION: Published findings on the associations between smoking and the incidence of cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are inconsistent. We aimed to generate prospective evidence on these relationships overall and by anatomical site. METHODS: We followed 1,223,626 women without prior cancer by electronic linkage to national cancer registration data. Questionnaire information about smoking and other factors was recorded at recruitment (1996-2001) and every 3-5 years subsequently...
June 14, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29894529/squamoid-eccrine-ductal-carcinoma
#4
Jason Jacob, Lisa Kugelman
Squamoid eccrine ductal carcinoma (SEDC) is an extremely rare cutaneous tumor of unknown etiology. We report the case of a 77-year-old man with a history of treated chronic lymphocytic leukemia along with numerous basal cell and squamous cell carcinomas who presented for evaluation of a 5-cm, stellate, sclerotic plaque on the left chest of approximately 2 years' duration and a suspicious 3-mm pink papule on the right nasal sidewall of 2 months' duration. Initial histology of both lesions revealed carcinoma with squamous and ductal differentiation that extended from the undersurface of the epidermis, favoring a diagnosis of SEDC...
May 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29894408/long-term-topical-corticosteroid-use-and-risk-of-skin-cancer-a-systematic-review
#5
Sonia Ratib, Esther Burden-Teh, Jo Leonardi-Bee, Catherine Harwood, Fiona Bath-Hextall
OBJECTIVE: The objective of this systematic review was to synthesize available research evidence to determine the risk of skin cancer in patients with long-term use of topical corticosteroids (TCS). INTRODUCTION: Topical corticosteroids are one of the most commonly prescribed medicines in dermatology and the mainstay of the treatment of atopic dermatitis and other skin conditions such as psoriasis. They are often required for months or years to control the disease and ultimately restore patients' quality of life...
June 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29808169/a-review-of-the-literature-of-surgical-and-nonsurgical-treatments-of-invasive-squamous-cells-carcinoma
#6
REVIEW
Concetta Potenza, Nicoletta Bernardini, Veronica Balduzzi, Luigi Losco, Alessandra Mambrin, Anna Marchesiello, Ersilia Tolino, Sara Zuber, Nevena Skroza, Ilaria Proietti
Cutaneous squamous cell carcinoma (cSCC) is an increasing public health problem. It is a primary malignant skin tumor with Malpighian differentiation and together with basal cell carcinoma is classified among nonmelanoma skin cancers (NMSCs). cSCC usually occurs on photoexposed areas, such as the head, the neck, and the extremities, and its incidence increases with age. Invasive forms of this skin tumor tend to be more aggressive showing a higher metastatic potential, usually regarding regional lymph nodes...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29785327/ex-vivo-confocal-microscopy-an-emerging-technique-in-dermatology
#7
Elisa Cinotti, Jean Luc Perrot, Bruno Labeille, Frédéric Cambazard, Pietro Rubegni
This review aims to give an overview of the current available applications of ex vivo confocal microscopy (EVCM) in dermatology. EVCM is a relatively new imaging technique that allows microscopic examination of freshly excised unfixed tissue. It enables a rapid examination of the skin sample directly in the surgery room and thus represents an alternative to the intraoperative micrographic control of the surgical margins of cutaneous tumors by standard microscopic examination on cryopreserved sections during Mohs surgery...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29765269/mohs-micrographic-surgery-development-technique-and-applications-in-cutaneous-malignancies
#8
REVIEW
Eillen Luisa A Chen, Divya Srivastava, Rajiv I Nijhawan
Mohs micrographic surgery (MMS) is a specialized technique for treating skin malignancies that offers the highest cure rate by allowing histological evaluation of the entire peripheral and deep margins. MMS also maximally preserves as much uninvolved, normal adjacent tissue as possible, allowing for the best cosmetic and functional outcomes. When used for appropriate indications, this technique is also more cost-effective than other treatment modalities. In this article, the authors will discuss the development of MMS, the steps involved in this procedure, and the indications for this technique...
May 2018: Seminars in Plastic Surgery
https://www.readbyqxmd.com/read/29756221/rapid-growth-rate-is-associated-with-poor-prognosis-in-cutaneous-squamous-cell-carcinoma
#9
J Cañueto, J Martín-Vallejo, E Cardeñoso-Álvarez, E Fernández-López, J Pérez-Losada, C Román-Curto
BACKGROUND: Cutaneous squamous cell carcinoma (cSCC) represents the most common form of skin cancer after basal cell carcinoma, and can be both locally invasive and metastatic to distant sites. Growth rate (GR) has been poorly evaluated in cSCC, despite clinical evidence suggesting that GR is an important risk factor in cSCC. AIM: To analyse the influence of GR in cSCC prognosis. METHODS: We retrospectively evaluated GR in a series of 90 cSCCs and tried to correlate GR with prognosis in cSCC...
May 13, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29752702/daylight-photodynamic-therapy-for-actinic-keratoses
#10
REVIEW
Colin A Morton, Lasse R Braathen
Topical photodynamic therapy (PDT) using daylight is effective in the treatment of actinic keratoses (AKs), offering the potential for treatment of large fields such as full face and balding scalp, but with minimal therapy-associated pain. Comparison with conventional PDT indicates similar efficacy for thin and moderate-thickness AKs, but with significantly less discomfort/pain, driving a patient preference for daylight-mediated PDT (DL-PDT) compared with conventional PDT using high-intensity office/hospital-based light sources...
May 11, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29746428/review-of-nonmelanoma-skin-cancer-in-african-americans-hispanics-and-asians
#11
Shauna Higgins, Azadeh Nazemi, Maggie Chow, Ashley Wysong
BACKGROUND: Skin cancer has traditionally been studied in Caucasian skin. Although it does occur with increased relative frequency in Caucasians, patients with skin of color suffer from elevated morbidity and mortality when diagnosed with skin cancer. OBJECTIVE: To detail the unique demographic and clinical features of nonmelanoma skin cancer (NMSC) in patients with skin of color, including Hispanic, African American, and Asian patients. MATERIALS AND METHODS: A complete PubMed search was conducted spanning dates from 1947 to June 2017 yielding a total of 185 manuscripts, from which 45 were included in this review...
May 9, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29745269/biophysical-and-photobiological-basics-of-water-filtered-infrared-a-hyperthermia-of-superficial-tumors
#12
Peter Vaupel, Helmut Piazena, Werner Müller, Markus Notter
Thermography-controlled, water-filtered infrared-A (wIRA) is a novel, effective and approved heating technique listed in the ESHO quality assurance guidelines for superficial hyperthermia clinical trials (2017). In order to assess the special features and the potential of wIRA-hyperthermia (wIRA-HT), detailed and updated information about its physical and photobiological background is presented. wIRA allows for (a) application of high irradiances without skin pain and acute grade 2-4 skin toxicities, (b) prolonged, therapeutically relevant exposure times using high irradiances (150-200 mW/cm2 ) and (c) faster and deeper heat extension within tissues...
May 10, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29742557/cutaneous-squamous-cell-carcinoma-with-sclerosing-features-an-uncommon-and-potentially-aggressive-variant
#13
Shira Ronen, Alejandro A Gru, Mary M Noland, David M Rowe, Mark R Wick
Sclerosing squamous cell carcinoma (SCC), also known as "desmoplastic" SCC, is a rare subtype of cutaneous malignancy. This variant is clinically significant because it is associated with an increased risk of local recurrence and metastasis. We herein present 16 examples of sclerotic SCC of the skin in 8 men and 3 women, with a median age of 66 years. The most common site of origin for this tumor is the skin of the head and neck, including the scalp (5 tumors in 2 different patients), forehead (3 cases), nasal ala (2 cases), neck (2 cases in the same patient), ear (2 cases), cheek (1 case), and chest (1 case)...
May 8, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29735815/primary-cutaneous-cribriform-apocrine-carcinoma-case-report-and-literature-review
#14
Jiann-Der Wu, Chih-Hsuan Changchien, Kai-Sheng Liao
Primary cutaneous cribriform apocrine carcinoma is a rare but distinct variant of primary cutaneous apocrine carcinoma and it is considered a low grade malignancy. We herein present a case of primary cutaneous cribriform apocrine carcinoma at the neck of a 26-year-old female. The tumor features a relatively well-circumscribed border and multiple aggregations of mildly pleomorphic epithelial cells with large ovoid nuclei, small nucleoli and abundant eosinophilic cytoplasms. Cribriform and tubular structures are the major architectural patterns...
May 2, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29723365/lymphoepithelioma-like-carcinoma-of-the-skin
#15
Cristiano Claudino Oliveira, Vinicius Cardoso Nóbrega, Mariângela Esther Alencar Marques
Primary cutaneous lymphoepithelioma-like carcinoma is a rare disease with low metastatic potential. Its morphologic and pathological features are similar to those of nasopharyngeal lymphoepithelial carcinoma. We report the case of a 60-year-old man with an infrapalpebral pearly papule, measuring 0.6 cm in diameter. The lesion was excised with a clinical hypothesis of basal cell carcinoma or squamous cell carcinoma. Histopathological analysis revealed a malignant neoplasm with syncytial arrangement of cells with vesicular nuclei, associated with dense lymphocytic infiltrate...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29686913/oral-capecitabine-achieves-response-in-metastatic-eccrine-carcinoma
#16
Kristian Larson, Hani M Babiker, Andrew Kovoor, Joy Liau, Jordan Eldersveld, Emad Elquza
The low prevalence rate and limited literature on eccrine carcinoma (EC) pose a challenge to properly diagnosing and treating this rare malignancy. EC lesions tend to present similarly to other cutaneous neoplasms and dermatitis-like conditions. Efficacious treatment guidelines have not been established for patients diagnosed with EC, and few treatment regimens have demonstrated clinical benefit. Due to the high metastatic potential of EC, recognizing the clinical presentation, properly diagnosing, and utilizing beneficial treatment options are important for managing this disease...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29676381/ectopic-hidradenoma-papilliferum-of-eyelid-a-rare-entity-with-diagnostic-challenge
#17
Prakriti Shukla, Anil K Malaviya
Hidradenoma papilliferum is a rare cutaneous adnexal tumour of middle aged females arising mainly in the apocrine sweat glands of perianal and genital region. Ectopic forms of this entity have been described with majority of them occurring on the head and neck region. We report a case of 16 years young male who presented with two small, well circumscribed, greyish-brown, firm, nodules on his left upper and lower eyelid. A clinical impression of basal cell carcinoma was assumed but on histopathological examination it was diagnosed as hidradenoma papilliferum of eyelid...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29675782/identification-of-human-cutaneous-basal-cell-carcinoma-cancer-stem-cells
#18
Huw Morgan, Carlotta Olivero, Girish K Patel
The cancer stem cell model states that a subset of tumor cells, called "cancer stem cells," can initiate and propagate tumor growth through self-renewal, high proliferative capacity, and their ability to recreate tumor heterogeneity. In basal cell carcinoma (BCC), we have shown that tumor cells that express the cell surface protein CD200 fulfill the cancer stem cell hypothesis. CD200+ CD45- BCC cells represent 0.05-3.96% of all BCC cells and reside in small clusters at the tumor periphery. Using a novel, reproducible in vivo xenograft growth assay, we determined that tumor-initiating cell (TIC) frequencies are approximately 1 per 1...
April 20, 2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29661336/cutaneous-head-and-neck-malignancies-in-the-elderly
#19
REVIEW
Brian B Hughley, Cecelia E Schmalbach
Cutaneous malignancy of the head and neck affects a large proportion of elderly patients. The severity ranges from small, easily treatable lesions to large, invasive, potentially metastatic tumors. Surgical treatment is the primary treatment of most skin cancers; however, geriatric patients are more likely to have multiple comorbidities that increase the risk of surgery. Multiple treatment modalities exist, including surgical, radiation, and medical therapy. Recommendations and treatment options for basal cell carcinoma, squamous cell carcinoma, Merkel cell carcinoma, and melanoma are outlined and reviewed...
May 2018: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/29644193/nonvenereal-penile-dermatoses-a-retrospective-study
#20
Ana Marcos-Pinto, Luís Soares-de-Almeida, João Borges-Costa
Context: A variety of nonvenereal diseases can affect the penis and diminish quality of life. Many present similar clinical features and a cutaneous biopsy may be necessary to clarify the diagnosis. Aims: To characterize nonvenereal penile dermatoses with histological confirmation in a southwestern Europe hospital during a 9-year period. Materials and Methods: A retrospective study was conducted. We reviewed all penile biopsies performed between January 1, 2007 and December 31, 2015 and studied the causes of the nonvenereal penile dermatoses...
March 2018: Indian Dermatology Online Journal
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