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cutaneous basal cell carcinoma

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https://www.readbyqxmd.com/read/27920067/injectable-diphenhydramine-used-as-anaesthetic-for-wide-local-excision-with-flap-closure
#1
Laura E Pickett, Jillian Macdonald
BACKGROUND: Lidocaine-allergic patients pose a challenge for cutaneous surgical procedures. We present a case of a successful wide local excision with flap closures on the face using topical tetracaine followed by infiltration with 1% diphenhydramine. CASE SUMMARY: An 84-year-old woman, with a lidocaine intolerance, presented to the Mohs surgery clinic for wide local excision of a nodular basal cell carcinoma on her right medial cheek. Successful anaesthesia was achieved using topical 4% tetracaine followed by intradermal and subcutaneous injection of 1% diphenhydramine...
December 5, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27908679/skin-surface-brachytherapy-a-survey-of-contemporary-practice-patterns
#2
Anna O Likhacheva, Phillip M Devlin, Shervin M Shirvani, Christopher A Barker, Phillip Beron, Ajay Bhatnagar, Stephen W Doggett, Lawrence Hochman, Charles Hsu, Michael Kasper, Martin Keisch, Subhakar Mutyala, Bradley Prestidge, Silvia Rodriguez Villalba, Vershalee Shukla, Srinath Sundararaman, Mitchell Kamrava
PURPOSE: The aim of this study was to define current patterns of care among radiation oncologists who use skin surface brachytherapy for the treatment of cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) in academic and community settings. METHODS AND MATERIALS: A 30-question electronic survey was administered to clinician members of the American Brachytherapy Society. The respondents were asked to provide details regarding their clinical practice and their approach to skin surface brachytherapy...
November 28, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27896185/the-relationship-between-the-size-and-the-invasion-depth-of-tumors-in-head-and-neck-cutaneous-squamous-cell-carcinoma
#3
Sam Yong Lee, Won Joo Hwang, Kyung Pil Kim, Hong Min Kim, Jae Ha Hwang, Kwang Seog Kim
BACKGROUND: Cutaneous squamous cell carcinoma (SCC), which occurs in keratinocytes of the epidermis and is the second most common skin cancer, has a more invasive growth pattern and higher potential to metastasize than basal cell carcinoma. Total excision of the primary tumor is the treatment of choice. For clear excision of the tumor, invasion depth is one of the most important factors. This study was conducted to clarify the relationship between the size and the invasion depth of cutaneous SCC...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27892658/occupational-syncarcinogenesis-in-the-skin-combined-effects-of-two-carcinogens-from-the-german-occupational-disease-list
#4
Heinrich Dickel, Otto Blome, Beate Dickel, Thomas Bruckner, Eggert Stockfleth, Silas Paras Soemantri
BACKGROUND: Though scientifically undisputed, cutaneous syncarcinogenesis is not reflected in German occupational disease (OD) regulations, which tend to be guided by the tenet of monocausality. Recognition of nonmelanoma skin cancer (NMSC) and its precursor lesions as OD requires individual assessment as to whether the requirements pursuant to either OD 5103 (occupational exposure to natural UV radiation) or OD 5102 (occupational exposure to polycyclic aromatic hydrocarbons) are fulfilled...
November 28, 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27879972/responses-of-metastatic-basal-cell-and-cutaneous-squamous-cell-carcinomas-to-anti-pd1-monoclonal-antibody-regn2810
#5
Gerald S Falchook, Rom Leidner, Elizabeth Stankevich, Brian Piening, Carlo Bifulco, Israel Lowy, Matthew G Fury
BACKGROUND: Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (CSCC) share exposure to UV light as the dominant risk factor, and these tumors therefore harbor high mutation burdens. In other malignancies, high mutation burden has been associated with clinical benefit from therapy with antibodies directed against the Programmed Death 1 (PD-1) immune checkpoint receptor. Highly mutated tumors are more likely to express immunogenic tumor neoantigens that attract effector T cells, which can be unleashed by blockade of the PD-1 immune checkpoint...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27869450/basal-cell-carcinoma-of-the-skin-with-mixed-histomorphology-a%C3%A2-comparative-study
#6
Vladimír Bartoš, Milada Kullová
Basal cell carcinoma (BCC) of the skin exhibits a very heterogeneous histomorphology, on the basis of which it is classified into several subtypes and variants. In many cases, however, a definite categorization remains difficult, because BCC may consist of more than one histopathological subtype. There are limited data exploring the characteristics of these mixed BCCs, since they have not been specifically analysed. The aim of this study was to estimate the prevalence of BCCs with mixed histomorphology observed in a set of primary BCCs and to compare their clinicopathological features with a single type BCC subgroup...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27843260/gorlin-goltz-syndrome-a-rare-case-report-of-a-11-year-old-child
#7
Sandeep Tandon, Yashwant Chauhan, Meenakshi Sharma, Manish Jain
: Gorlin-Goltz Syndrome, also known as nevoid basal cell carcinoma syndrome (NBCCS), is an autosomal dominant trait caused due to mutations in the patched tumor suppressor gene (PTCH) gene found on the long arm of chromosome 9. The syndrome is characterized by the presence of odontogenic keratocysts (OKCs), basal cell carcinomas, and skeletal malformations. Early diagnosis of the syndrome can be done by pedodontist as OKC is one of the early manifestations of the syndrome. Early diagnosis and treatment is important for long-term prognosis of the syndrome by reducing the severity of cutaneous carcinomas and deformities due to jaw cyst...
July 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27833340/retrospective-outcome-analysis-of-39-patients-who-underwent-lip-surgery-for-cutaneous-carcinoma
#8
Alice Guyon, Romain Bosc, Frederic Lange, Nicolas Ortonne, Françoise Plantier, Olivier Chosidow, Pierre Wolkenstein, Barbara Hersant, Jean-Paul Meningaud
PURPOSE: The treatment of lip carcinomas needs tumor surgical resection with safety margins respect. The aim of this study was to report the oncologic and aesthetic/functional outcomes of a retrospective monocentric case series of 39 patients treated for cutaneous lip cancer. METHODS: This retrospective study assessed 56 patients who were treated for a lip carcinoma between 2008 and 2012 and included 39 patients with cutaneous lip basal cell carcinoma or squamous cell carcinoma...
December 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27811637/cutaneous-horn-of-the-eyelid-in-13-cases
#9
Renelle Pointdujour-Lim, Molly R Marous, Celine E Satija, Alexzandra M Douglass, Ralph C Eagle, Jerry A Shields, Carol L Shields
INTRODUCTION: Cutaneous horn of the eyelid is uncommon. The authors evaluate the features of benign, premalignant, and malignant tumors at the base of cutaneous horn of the eyelid. OBJECTIVE: To describe the clinical and histopathologic features of cutaneous horn of the eyelid. DESIGN: A retrospective analysis of 13 cases of cutaneous horn of the eyelid treated between 1994 and 2014 was performed. PARTICIPANTS: Thirteen patients participated in this study...
November 2, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27780641/three-layer-reconstruction-of-lower-third-nasal-defects-using-forehead-flap-reversed-nasolabial-flap-and-auricular-cartilage
#10
A Ghassemi, S S Ahmed, H Ghanepur, A Modabber
The reconstruction of a full-thickness defect of the distal third of the nose requires the restoration of all three anatomical layers. A practical method for three-layer reconstruction of the lower third of the nose and the long-term results of this technique are presented herein. A combined reconstruction technique was utilized, including a reverse subcutaneous pedicled nasolabial flap to restore the nasal mucosa, an auricular cartilage graft for structural support, and a forehead flap for cutaneous coverage of the defect...
October 22, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27768120/orbital-exenteration-for-advanced-periorbital-non-melanoma-skin-cancer-prognostic-factors-and-survival
#11
R C Gerring, C T Ott, J M Curry, Z B Sargi, S T Wester
PurposeTo describe prognostic factors and survival outcomes in patients who underwent orbital exenteration for periocular non-melanoma cutaneous malignancies.MethodsThe authors performed an institutional review board-approved retrospective review of all patients who underwent orbital exenteration for non-melanoma periocular cutaneous malignancies at a tertiary care hospital system over a 10-year period. Patient demographics, tumor, and treatment data were recorded. Survival outcomes included disease-free survival (DFS) and overall survival (OS)...
October 21, 2016: Eye
https://www.readbyqxmd.com/read/27755173/management-of-mucosal-basal-cell-carcinoma-of-the-lip-an-update-and-comprehensive-review-of-the-literature
#12
Tiffany Loh, Ashley G Rubin, Shang I Brian Jiang
BACKGROUND: Basal cell carcinoma (BCC) is the most common malignancy in the United States. Most BCCs occur on cutaneous surfaces, but rare cases on the mucosal lip have also been documented. Because only a small number of mucosal BCC (mBCC) cases have been reported, data on their clinical characteristics and management are limited. OBJECTIVE: To perform an updated literature review of the management of mBCCs on the lip. METHODS: A comprehensive literature review was conducted through a search of the PubMed database with the key phrases "mucosal basal cell carcinoma," "basal cell carcinoma mucosa," and "basal cell carcinoma lip mucosa...
December 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27732729/study-on-the-risk-of-cutaneous-squamous-cell-carcinoma-after-vismodegib-therapy-for-basal-cell-carcinoma-reply
#13
Shufeng Li, Anne Lynn S Chang
No abstract text is available yet for this article.
October 1, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27732728/study-on-the-risk-of-cutaneous-squamous-cell-carcinoma-after-vismodegib-therapy-for-basal-cell-carcinoma-not-a-case-control-study
#14
Susana Puig, Francesca Sampogna, Antonio Tejera-Vaquerizo
No abstract text is available yet for this article.
October 1, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27732727/study-on-the-risk-of-cutaneous-squamous-cell-carcinoma-after-vismodegib-therapy-for-basal-cell-carcinoma-not-a-case-control-study
#15
Petter Gjersvik
No abstract text is available yet for this article.
October 1, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27718152/differential-bmi1-twist1-snai2-mrna-expression-pattern-correlation-with-malignancy-type-in-a-spectrum-of-common-cutaneous-malignancies-basal-cell-carcinoma-squamous-cell-carcinoma-and-melanoma
#16
F Vand-Rajabpour, N Sadeghipour, S Saee-Rad, H Fathi, P Noormohammadpour, M Yaseri, K K Hesari, Z Bagherpour, M Tabrizi
PURPOSE: Melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) can be used as a unique model to identify molecular mechanisms to distinguish rarely metastatic (BCC), often metastatic (SCC) and most metastatic (melanoma) cancer. It is known that epithelial-mesenchymal transition and stemness transcription factors (TWIST1, SNAI2/SLUG, and BMI1) play an important role in metastasis and their dysregulation has been demonstrated in metastatic cancers. We hypothesized that this spectrum of cutaneous cancers (BCC, SCC, and melanoma) would be a unique cancer model system to elucidate steps toward cancer invasion and metastasis...
October 7, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27663092/non-genetic-risk-factors-for-cutaneous-melanoma-and-keratinocyte-skin-cancers-an-umbrella-review-of-meta-analyses
#17
Lazaros Belbasis, Irene Stefanaki, Alexander J Stratigos, Evangelos Evangelou
BACKGROUND: Skin cancers have a complex disease mechanism, involving both genetic and non-genetic risk factors. Numerous meta-analyses have been published claiming statistically significant associations between non-genetic risk factors and skin cancers without applying a thorough methodological assessment. OBJECTIVE: The present study maps the literature on the non-genetic risk factors of skin cancers, assesses the presence of statistical biases and identifies the associations with robust evidence...
September 13, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27648386/pigmented-eccrine-poroma-dermoscopic-and-confocal-features
#18
Caterina Bombonato, Simonetta Piana, Elvira Moscarella, Aimillios Lallas, Giuseppe Argenziano, Caterina Longo
Eccrine poroma is a rare benign adnexal tumor of epithelial cells originating from the terminal ductal portion of the sweat glands that is typically located on palms and soles, although other cutaneous sites can be affected [1]. It is usually nonpigmented even if there is a pigmented variant that corresponds to 17% of cases and it is usually underdiagnosed, since it is mistakenly confused with other pigmented tumors [2,3]. Dermoscopy and reflectance confocal microscopy (RCM) may assist in the correct diagnosis of this tumor...
July 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27631871/rare-association-of-cystic-squamous-cell-carcinoma-and-small-lymphocytic-b%C3%A2-cell-lymphoma-successful-surgical-approach
#19
Uwe Wollina, Jacqueline Schönlebe, Birgit Heinig, Andreas Nowak, Anastasiya Atanasova Chokoeva, Georgi Tchernev
Non-melanoma skin cancer is the most common type of cutaneous neoplasm worldwide. While basal cell carcinoma is the most common tumor, squamous cell carcinoma (SCC) causes higher morbidity and has a risk of metastatic spread, depending on immune status, tumor size, and desmoplastic growth. We reported the case of a 77 year old male patient with retroauricular tumor, which started growing 3 years ago and was excised, buth relapsed three times. The initial diagnosis was infundibular cyst. Delayed Mohs surgery was performed, as was an additional open lymph node biopsy of the patient's right groin, on the occasion of an indolent swelling of the same which developed within 3 months...
September 8, 2016: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27631010/nonconventional-use-of-flash-lamp-pulsed-dye-laser-in-dermatology
#20
Steven Nisticò, Piero Campolmi, Silvia Moretti, Ester Del Duca, Nicola Bruscino, Rossana Conti, Andrea Bassi, Giovanni Cannarozzo
Flash-lamp pulsed-dye laser (FPDL) is a nonablative technology, typically used in vascular malformation therapy due to its specificity for hemoglobin. FPDL treatments were performed in a large group of patients with persistent and/or recalcitrant different dermatological lesions with cutaneous microvessel involvement. In particular, 149 patients (73 males and 76 females) were treated. They were affected by the following dermatological disorders: angiokeratoma circumscriptum, genital and extragenital viral warts, striae rubrae, basal cell carcinoma, Kaposi's sarcoma, angiolymphoid hyperplasia, and Jessner-Kanof disease...
2016: BioMed Research International
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