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cutaneous basal cell carcinoma

Shufeng Li, Anne Lynn S Chang
No abstract text is available yet for this article.
October 1, 2016: JAMA Dermatology
Susana Puig, Francesca Sampogna, Antonio Tejera-Vaquerizo
No abstract text is available yet for this article.
October 1, 2016: JAMA Dermatology
Petter Gjersvik
No abstract text is available yet for this article.
October 1, 2016: JAMA Dermatology
F Vand-Rajabpour, N Sadeghipour, S Saee-Rad, H Fathi, P Noormohammadpour, M Yaseri, K K Hesari, Z Bagherpour, M Tabrizi
PURPOSE: Melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) can be used as a unique model to identify molecular mechanisms to distinguish rarely metastatic (BCC), often metastatic (SCC) and most metastatic (melanoma) cancer. It is known that epithelial-mesenchymal transition and stemness transcription factors (TWIST1, SNAI2/SLUG, and BMI1) play an important role in metastasis and their dysregulation has been demonstrated in metastatic cancers. We hypothesized that this spectrum of cutaneous cancers (BCC, SCC, and melanoma) would be a unique cancer model system to elucidate steps toward cancer invasion and metastasis...
October 7, 2016: Clinical & Translational Oncology
Lazaros Belbasis, Irene Stefanaki, Alexander J Stratigos, Evangelos Evangelou
BACKGROUND: Skin cancers have a complex disease mechanism, involving both genetic and non-genetic risk factors. Numerous meta-analyses have been published claiming statistically significant associations between non-genetic risk factors and skin cancers without applying a thorough methodological assessment. OBJECTIVE: The present study maps the literature on the non-genetic risk factors of skin cancers, assesses the presence of statistical biases and identifies the associations with robust evidence...
September 13, 2016: Journal of Dermatological Science
Caterina Bombonato, Simonetta Piana, Elvira Moscarella, Aimillios Lallas, Giuseppe Argenziano, Caterina Longo
Eccrine poroma is a rare benign adnexal tumor of epithelial cells originating from the terminal ductal portion of the sweat glands that is typically located on palms and soles, although other cutaneous sites can be affected [1]. It is usually nonpigmented even if there is a pigmented variant that corresponds to 17% of cases and it is usually underdiagnosed, since it is mistakenly confused with other pigmented tumors [2,3]. Dermoscopy and reflectance confocal microscopy (RCM) may assist in the correct diagnosis of this tumor...
July 2016: Dermatology Practical & Conceptual
Uwe Wollina, Jacqueline Schönlebe, Birgit Heinig, Andreas Nowak, Anastasiya Atanasova Chokoeva, Georgi Tchernev
Non-melanoma skin cancer is the most common type of cutaneous neoplasm worldwide. While basal cell carcinoma is the most common tumor, squamous cell carcinoma (SCC) causes higher morbidity and has a risk of metastatic spread, depending on immune status, tumor size, and desmoplastic growth. We reported the case of a 77 year old male patient with retroauricular tumor, which started growing 3 years ago and was excised, buth relapsed three times. The initial diagnosis was infundibular cyst. Delayed Mohs surgery was performed, as was an additional open lymph node biopsy of the patient's right groin, on the occasion of an indolent swelling of the same which developed within 3 months...
September 8, 2016: Wiener Medizinische Wochenschrift
Steven Nisticò, Piero Campolmi, Silvia Moretti, Ester Del Duca, Nicola Bruscino, Rossana Conti, Andrea Bassi, Giovanni Cannarozzo
Flash-lamp pulsed-dye laser (FPDL) is a nonablative technology, typically used in vascular malformation therapy due to its specificity for hemoglobin. FPDL treatments were performed in a large group of patients with persistent and/or recalcitrant different dermatological lesions with cutaneous microvessel involvement. In particular, 149 patients (73 males and 76 females) were treated. They were affected by the following dermatological disorders: angiokeratoma circumscriptum, genital and extragenital viral warts, striae rubrae, basal cell carcinoma, Kaposi's sarcoma, angiolymphoid hyperplasia, and Jessner-Kanof disease...
2016: BioMed Research International
S Kaur, P Sahu, S Dayal, V K Jain, N Jindal, V Jairath
Cutaneous Squamous cell carcinoma (SCC) is the second most common form of non-melanotic skin cancer after basal cell carcinoma (BCC). It is a well-known complication of discoid lupus erythematosus (DLE) and usually favours the depigmented lesions located over sun-exposed areas. The clinical course of this complication may be aggressive, with a high risk of mortality. Literature describes numerous case reports of SCC complicating the lesions of DLE but mutilating SCC is rarely mentioned. Here in, we report a rare case of mutilating squamous cell carcinoma arising in an early (two years duration) lesion of DLE...
February 22, 2016: West Indian Medical Journal
Andrew J Colebatch, Leon Di Stefano, Stephen Q Wong, Ross D Hannan, Paul M Waring, Alexander Dobrovic, Grant A McArthur, Anthony T Papenfuss
Most cancer DNA sequencing studies have prioritized recurrent non-synonymous coding mutations in order to identify novel cancer-related mutations. Although attention is increasingly being paid to mutations in non-coding regions, standard approaches to identifying significant mutations may not be appropriate and there has been limited analysis of mutational clusters in functionally annotated non-coding regions. We sought to identify clustered somatic mutations (hotspot regions across samples) in functionally annotated regions in melanoma and other cutaneous malignancies (cutaneous squamous cell carcinoma, basal cell carcinoma and Merkel cell carcinoma)...
September 7, 2016: Oncotarget
Hamideh Kadeh, Shirin Saravani, Fatemeh Heydari, Saeed Shahraki
Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC) are two common skin malignancies with different potentials for invasion and metastasis. The mechanism responsible for various growth patterns observed in SCC and BCC is still not fully understood. The aim of this study was to investigate the expression of matrix metalloproteinase-10 in non-melanoma skin cancers, including BCC and SCC of the head and neck. The study group consisted of 60 specimens, including 30 BCC and 30 cutaneous SCC of the head and neck...
July 1, 2016: Pathology, Research and Practice
Tobin J Strom, Jimmy J Caudell, Louis B Harrison
BACKGROUND: For decades radiotherapy (RT) has been shown to treat skin cancers; however, the indications, delivery methods, and techniques for RT continue to evolve. METHODS: Relevant prospective and retrospective reports were reviewed that addressed outcomes with, indications for, and delivery techniques used with RT for the management of cutaneous basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the head and neck. RESULTS: Rates of local control higher than 90% are typically achievable for early-stage BCC and SCC of the head and neck...
July 2016: Cancer Control: Journal of the Moffitt Cancer Center
Z Liu, L L Ma, S D Zhang, M Lu, Y Tian, Q He, J Jin
To explore the clinical pathological characteristics and improve the recognition in the diagnosis and treatment of basal cell carcinoma (BCC) of prostate. Three cases of BCC of prostate were reported and the relevant literature was reviewed to investigate the diagnosis and treatment of this disease. We analyzed three cases of prostatic BCC. Their ages were within a range of 57 to 83 years. One of them complained of hematuria and two complained of dysuria. All of them presented with prostatic hyperplasia. Two of them presented with high prostate specific antigen (PSA) and one with normal PSA...
February 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Maya Goder, Rachel Kornhaber, Daniele Bordoni, Eyal Winkler, Josef Haik, Ariel Tessone
Basal cell carcinomas (BCCs) are one of the most frequent cutaneous malignancies. The majority of BCCs are reported to occur on the auricular helix and periauricular region due to ultraviolet light exposure. Despite the frequency of BCCs, those that develop within scar tissue are rare, and the phenomenon of keloid BCCs has rarely been reported in the literature. Keloid collagen within BCCs is associated with morphoeiform characteristics, ulceration, or necrosis. Extensive keloid collagen is often seen in BCCs of the ear region, a site prone to keloid scarring...
2016: OncoTargets and Therapy
C Hennequin, E Rio, M-A Mahé
The indications of radiotherapy for skin cancers are not clearly defined because of the lack of randomised trials or prospective studies. For basal cell carcinomas, radiotherapy frequently offers a good local control, but a randomized trial showed that surgery is more efficient and less toxic. Indications of radiotherapy are contra-indications of surgery for patients older than 60, non-sclerodermiform histology and occurring in non-sensitive areas. Adjuvant radiotherapy could be proposed to squamous cell carcinomas, in case of poor prognostic factors...
September 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
J Cañueto, E Cardeñoso, J L García, Á Santos-Briz, A Castellanos-Martín, E Fernández-López, A Blanco Gómez, J Pérez-Losada, C Román-Curto
INTRODUCTION: Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans, after basal cell carcinoma, and its incidence is dramatically rising. CSCC is rarely problematic, but given its high frequency, the absolute number of complicated cases is also high. It is necessary to identify molecular markers to recognize those CSCC with poor prognosis. There is controversy concerning the role of EGFR (epidermal growth factor receptor) as a marker of prognosis in CSCC...
August 11, 2016: British Journal of Dermatology
Saraswathy Sreeram, Flora Dorothy Lobo, Ramdas Naik, Urmila Niranjan Khadilkar, Hema Kini, Ullal Anand Kini
INTRODUCTION: Basal Cell Carcinoma (BCC) is the most common skin cancer worldwide, which appears over sun-exposed skin as slow-growing, locally invasive lesion that rarely metastasizes. Many phenotypic presentations are possible. BCCs are more common in males and tend to occur in older people. Majority is found on the head and neck. Many histopathological subtypes have been defined including nodular, micronodular, cystic, superficial, pigmented, adenoid, infiltrating, sclerosing, keratotic, infundibulocystic, metatypical, basosquamous and fibroepitheliomatous...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
Danya Traboulsi, Habib Kurwa
BACKGROUND: Basal cell carcinoma (BCC) is the most common cutaneous malignancy. Terminal hair is not routinely removed for assessment of BCCs on the scalp and yet may obscure the true size of scalp BCCs. This can compromise effective management. OBJECTIVE: To underscore the importance of removing terminal hair on the scalp for an accurate assessment of clinical margins of BCC on the scalp. METHODS: We report 2 cases of cutaneous BCC arising on the scalp...
August 8, 2016: Journal of Cutaneous Medicine and Surgery
Aaron M Mullane, Alexis Ricci, Subhasis Misra, Nail Aydin
INTRODUCTION: Dermatofibrosarcoma protuberans (DFSP) is a rare, malignant, soft tissue neoplasm of the dermis. Tumor recurrence is common following resection, and can be locally devastating if not identified in a timely manner. We report a unique case of this rare tumor. This case poses the question of an association between basal cell carcinoma (BCC) and DFSP, and presents the possible need for increased awareness of DFSP for healthcare providers and patients with a history of non-melanoma skin cancers as well as surgical or burn scars...
2016: International Journal of Surgery Case Reports
Nicola di Meo, Giuseppe Stinco, Alessandro Gatti, Mattia Fadel, Silvia Vichi, Giusto Trevisan
Dear Editor, Apocrine hidradenoma is a rare benign adnexal tumor related to the more common poroma, as they both originate from sweat glands. Hidradenoma usually has an eccrine differentiation, but an apocrine differentiation is possible. Due to its rarity and non-specific clinical appearance it is difficult to differentiate it from other malignant cutaneous lesions. In this challenging task, dermatoscopy could be particularly helpful to better describe, recognize, and differentiate these lesions. Unfortunately, the literature offers only few dermatoscopic descriptions of this rare cutaneous neoplasm...
June 2016: Acta Dermatovenerologica Croatica: ADC
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