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cutaneous basal cell carcinoma

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https://www.readbyqxmd.com/read/29218279/non-metastatic-non-melanoma-skin-cancers-our-3-years-of-clinical-experiences
#1
Elif Sari
BACKGROUND: Nonmelanoma skin cancers (NMSC) constitute the largest group of skin cancers. In this study, NMSCs were analyzed retrospectively. METHODS: Between June 2013 and March 2017, demographics and comorbidities of patients underwent reconstructive surgery for NMSC; their risk factors, types, diameters, differentiation, localizations, follow-up times, treatment methods and complications were compared and statistically analyzed. RESULTS: Totally, 163 tumors [111 basal cell carcinoma and 52 cutaneous squamous cell carcinoma (cSCC)] were excized from 148 patients (63 females, 85 males)...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29215761/in-vivo-differentiation-of-common-basal-cell-carcinoma-subtypes-by-microvascular-and-structural-imaging-using-dynamic-optical-coherence-tomography
#2
Lotte Themstrup, Nathalie De Carvalho, Sabrina Mai Nielsen, Jonas Olsen, Silvana Ciardo, Sandra Schuh, Birgit Meinecke-Hansen Nørnberg, Julia Welzel, Martina Ulrich, Giovanni Pellacani, Gregor B E Jemec
BACKGROUND: The subtype of basal cell carcinoma (BCC) influences the choice of treatment. Optical coherence tomography (OCT) is a non-invasive imaging tool and recent development of angiographic version of OCT has extended the application of OCT to image the cutaneous microvasculature (so called dynamic OCT, D-OCT). This study explores D-OCT's ability to differentiate the common BCC subtypes by microvascular and structural imaging. METHODS: 81 patients with 98 BCC lesions, consisting of three subtypes: 27 superficial BCC (sBCC), 55 nodular BCC (nBCC) and 16 infiltrative BCC (iBCC), were D-OCT scanned at three European dermatology centres...
December 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29178483/electrochemotherapy-of-unresectable-cutaneous-tumors%C3%A2-with-reduced-dosages-of-intravenous-bleomycin-analysis-of-57-patients-from-the-inspect-international-network-for-sharing-practices-of-electrochemotherapy-registry
#3
R Rotunno, L G Campana, P Quaglino, F de Terlizzi, C Kunte, J Odili, J Gehl, S Ribero, S H Liew, R Marconato, M Brizio, P Curatolo
BACKGROUND: Electrochemotherapy (ECT) is currently used to treat unresectable superficial tumors of different histotypes through the combination of cytotoxic chemotherapy and local application of electric pulses. In 2006, a collaborative project defined the ESOPE (European Standard Operating Procedures of Electrochemotherapy) guidelines to standardize the procedure. The International Network for Sharing Practices of Electrochemotherapy (InspECT) aims to to refine the ESOPE and improve clinical practice...
November 24, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29176271/patterns-of-ultraviolet-radiation-exposure-and-skin-cancer-risk-the-e3n-sunexp-study
#4
Isabelle Savoye, Catherine M Olsen, David C Whiteman, Anne Bijon, Lucien Wald, Laureen Dartois, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Marina Kvaskoff
BACKGROUND: While ultraviolet (UV) radiation exposure is a recognized risk factor for skin cancer, associations are complex and few studies have allowed a direct comparison of exposure profiles associated with cutaneous melanoma, basal-cell carcinoma (BCC), and squamous-cell carcinoma (SCC) within a single population. METHODS: We examined associations between UV exposures and skin cancer risk in a nested case-control study within E3N, a prospective cohort of 98,995 French women born in 1925-1950...
November 25, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/29172905/retrospective-study-of-more-than-9000-feline-cutaneous-tumours-in-the-united-kingdom-2006-2013
#5
Nicola T Ho, Ken C Smith, Melanie J Dobromylskyj
Objectives The aim of the study was to utilise a large database available from a UK-based, commercial veterinary diagnostic laboratory to ascertain the prevalence of different forms of cutaneous neoplasia within the feline population, and to detect any breed, sex or age predilections for the more common tumours. Methods Records from the laboratory were searched for feline submissions received between 31 May 2006 and 31 October 2013. For masses arising within the skin for which histopathology had been performed, the diagnosis was recorded together with the breed, age, sex and neuter status of the cat...
March 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29166500/final-diagnosis-of-86-cases-included-in-differential-diagnosis-of-american-tegumentary-leishmaniasis-in-a-brazilian-sample-a-retrospective-cross-sectional-study
#6
Fernanda Tirelli, Sebastian Vernal, Ana Maria Roselino
BACKGROUND: Cutaneous leishmaniasis is distributed worldwide, including Brazil. Its several clinical forms need to be distinguished from other dermatoses. Clinical similarities and lack of a gold standard diagnostic tool make leishmaniasis-like lesions a challenging diagnosis. OBJECTIVES.: To report the final diagnosis of patients primarily suspected of having American tegumentary leishmaniasis (ATL). METHODS.: A retrospective cross-sectional study was conducted on the basis of medical records of 437 patients with clinical suspicion of ATL, registered in electronic hospital system between 1980 and 2013...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166499/skin-disorders-in-renal-transplant-recipients-a-retrospective-study
#7
Pedro Miguel Clemente Garrido, João Borges-Costa
BACKGROUND: Immunosuppressive therapy, which is necessary to avoid graft rejection in renal transplant recipients, presents an increased risk of several pathologies, namely infectious and neoplastic. OBJECTIVES: To identify the most frequent skin diseases and their clinical and demographical risk factors within a population of renal transplant recipients. METHODS: A retrospective study of renal transplant recipients referred to dermatology visit and observed for the first time from January 2008 to December 2014...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29159004/linear-malignant-melanoma-in-situ-reports-and-review-of-cutaneous-malignancies-presenting-as-linear-skin-cancer
#8
Philip R Cohen
Melanomas usually present as oval lesions in which the borders may be irregular. Other morphological features of melanoma include clinical asymmetry, variable color, diameter greater than 6 mm and evolving lesions. Two males whose melanoma in situ presented as linear skin lesions are described and cutaneous malignancies that may appear linear in morphology are summarized in this report. A medical literature search engine, PubMed, was used to search the following terms: cancer, cutaneous, in situ, linear, malignant, malignant melanoma, melanoma in situ, neoplasm, and skin...
September 18, 2017: Curēus
https://www.readbyqxmd.com/read/29148079/insm1-a-novel-nuclear-marker-in-merkel-cell-carcinoma-cutaneous-neuroendocrine-carcinoma
#9
Patrick S Rush, Jason N Rosenbaum, Madhuchhanda Roy, Rebecca M Baus, Daniel D Bennett, Ricardo V Lloyd
Merkel cell carcinoma (MCC) is a rare, clinically aggressive, cutaneous neuroendocrine (NE) neoplasm. As a tumor with small, round, blue cells, the histologic differential diagnosis for MCC can include melanoma, metastatic small cell carcinoma (SCC), nodular hematopoietic tumors, basal cell carcinoma (BCC), atypical variants of squamous carcinoma, and the uncommon occurrence of primary cutaneous Ewing sarcoma. In cases with atypical histology or without the classic immunophenotype the diagnosis can be challenging...
November 17, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29146125/all-cause-mortality-in-patients-with-basal-and-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#10
Mackenzie R Wehner, Wilmarie Cidre Serrano, Adi Nosrati, Patrick Michael Schoen, Mary-Margaret Chren, John Boscardin, Eleni Linos
BACKGROUND: There are varying reports of the association of basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC) with mortality. OBJECTIVE: To synthesize the available information on all-cause mortality after a diagnosis of BCC or SCC in the general population. METHODS: We searched PubMed (1966-present), Web of Science (1898-present), and Embase (1947-present) and hand-searched to identify additional records. All English articles that reported all-cause mortality in patients with BCC or SCC were eligible...
November 13, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29144206/c-jun-expression-in-lichen-planus-psoriasis-and-cutaneous-squamous-cell-carcinoma-an-immunohistochemical-study
#11
Asmaa Gaber Abdou, Alaa Hassan Marae, Mohammed Shoeib, Ghada Dawood, Enas Abouelfath
The AP-1 transcription factor complex is a key player in regulating inflammatory processes, cell proliferation, differentiation and cell transformation. The aim of the present study is to investigate C-Jun (one of AP-1complex) expression and its proliferative role in skin samples of lichen planus, psoriasis as common inflammatory skin diseases and squamous cell carcinoma using immunohistochemical method. The present study was carried out on skin biopsies of 15 psoriatic patients, 15 lichen planus patients, 15 SCC and 15 normal skin biopsies...
November 16, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/29136051/melanotrichoblastoma-a-rare-pigmented-variant-of-trichoblastoma
#12
Erin E Quist, Dominick J DiMaio
Trichoblastomas are rare cutaneous tumors arising from the hair bulb and mesenchyme. Although they are benign, they can pose a diagnostic dilemma for the clinician and pathologist because they clinically and histologically mimic more common lesions such as basal cell carcinomas (BCCs) and trichoepitheliomas. It is important for the clinician and pathologist to be aware of such tumors and their variants. We present a case of a melanotrichoblastoma, an exceedingly rare variant of trichoblastoma, as well as review the current literature on the clinical presentation and histologic differentiation of these unique tumors with their more commonly seen mimics...
October 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29124377/trendy-tattoos-maybe-a-serious-health-risk
#13
Felix J Paprottka, Nicco Krezdorn, Mustafa Narwan, Marvee Turk, Heiko Sorg, Ernst Magnus Noah, Detlev Hebebrand
BACKGROUND: The literature reports many cases of cutaneous malignancy in the setting of skin tattoos. In this study, we review the reported incidence of and risk factors for tattoo-associated skin cancer. METHODS: A PubMed literature review was performed for all cases of tattoo-associated skin cancer, including squamous cell carcinoma, basal cell carcinoma, malignant melanoma, keratoacanthoma, and other rare skin malignancies (source: PubMed/until June 2017). RESULTS: The authors identified 51 publications and 63 total cases of tattoo-associated skin cancer...
November 9, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29121636/improving-diagnostic-sensitivity-of-combined-dermoscopy-and-reflectance-confocal-microscopy-imaging-through-double-reader-concordance-evaluation-in-telemedicine-settings-a-retrospective-study-of-1000-equivocal-cases
#14
A M Witkowski, J Łudzik, F Arginelli, S Bassoli, E Benati, A Casari, N De Carvalho, B De Pace, F Farnetani, A Losi, M Manfredini, C Reggiani, J Malvehy, G Pellacani
BACKGROUND: Reflectance confocal microscopy (RCM) is an imaging device that permits non-invasive visualization of cellular morphology and has been shown to improve diagnostic accuracy of dermoscopically equivocal cutaneous lesions. The application of double reader concordance evaluation of dermoscopy-RCM image sets in retrospective settings and its potential application to telemedicine evaluation has not been tested in a large study population. OBJECTIVE: To improve diagnostic sensitivity of RCM image diagnosis using a double reader concordance evaluation approach; to reduce mismanagement of equivocal cutaneous lesions in retrospective consultation and telemedicine settings...
2017: PloS One
https://www.readbyqxmd.com/read/29063525/evaluation-of-the-national-skin-cancer-campaign-a-swiss-experience-of-euromelanoma
#15
Sven Lieberherr, S Morteza Seyed Jafari, Simone Cazzaniga, Enrica Bianchi, Bettina Schlagenhauff, Gion Tscharner, Jürg Hafner, Carlo Mainetti, Anne-Karine Lapointe, Robert E Hunger
AIMS OF THE STUDY: Skin cancer is a burden to healthcare and patients worldwide. The incidence of skin cancer has been rising during recent decades and this trend is expected to continue in the future. Numerous risk factors have been identified and prevention strategies developed. The Euromelanoma campaign is a pan-European skin cancer prevention programme, targeted to both primary and secondary prevention of malignant melanoma. The current study aimed to evaluate the results of the Swiss skin cancer screening day 2016...
October 24, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29058693/pathological-sampling-of-basal-cell-carcinoma-re-excision-specimens-how-much-is-enough
#16
Nima Mesbah Ardakani, Nathan Tobias Harvey, Vanessa Mansford, Benjamin Andrew Wood
Basal cell carcinoma (BCC) is the most common cutaneous malignancy, comprising approximately 75%-80% of all skin cancers. Surgical excision is the most common first line treatment modality, with the intent of obtaining clear margins. If the initial excision is incomplete or inadequate, a re-excision will often be performed in an attempt to achieve histological clearance. The pathological examination of these specimens requires a balance between the need for adequate assessment and efficient use of laboratory resources...
November 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29053046/microcystic-adnexal-carcinoma-of-the-orbit-mimicking-pagetoid-sebaceous-gland-carcinoma
#17
Bipasha Mukherjee, Nirmala Subramaniam, Krishna Kumar, Pratheeba Devi Nivean
Microcystic adnexal carcinoma (MAC) is a rare malignancy of sweat glands that has been reported most often on the face in the form of a cutaneous lesion, with the potential for deeper invasion. The synonyms of MAC include sclerosing sweat duct carcinoma, syringomatous carcinoma, and malignant syringoma. Clinically, MAC in the periocular area has been misdiagnosed as basal cell carcinoma, squamous cell carcinoma, or even chalazia. We report a case of MAC presenting clinically as sebaceous gland carcinoma with pagetoid spread for the first time in literature...
October 20, 2017: Orbit
https://www.readbyqxmd.com/read/29024374/human-papillomavirus-and-posttransplantation-cutaneous-squamous-cell-carcinoma-a-multicenter-prospective-cohort-study
#18
Jan N Bouwes Bavinck, Mariet C W Feltkamp, Adele C Green, Marta Fiocco, Sylvie Euvrard, Catherine A Harwood, Charlotte M Proby, Luigi Naldi, Janouk C D Diphoorn, Anna Venturuzzo, Gianpaolo Tessari, Ingo Nindl, Francesca Sampogna, Damiano Abeni, Rachel E Neale, Jelle J Goeman, Koen D Quint, Anne B Halk, Carmen Sneek, Roel E Genders, Maurits N C de Koning, Wim G V Quint, Ulrike Wieland, Sönke Weissenborn, Tim Waterboer, Michael Pawlita, Herbert Pfister
Organ transplant recipients (OTRs) have a 100-fold increased risk of cutaneous squamous cell carcinoma (cSCC). We prospectively evaluated the association between β genus human papillomaviruses (βPV) and keratinocyte carcinoma in OTRs. Two OTR cohorts without cSCC were assembled: cohort 1 was transplanted in 2003-2006 (n = 274) and cohort 2 was transplanted in 1986-2002 (n = 352). Participants were followed until death or cessation of follow-up in 2016. βPV infection was assessed in eyebrow hair by using polymerase chain reaction-based methods...
October 11, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29018888/-non-melanoma-skin-cancer-pathogenesis-prevalence-and-prevention
#19
A Zink
Non-melanoma skin cancer (NMSC) is the most common malignancy of the light-skinned population with an enormous socioeconomic impact. Historically known as incurable under the term noli me tangere (transl. do not touch me), today various non-melanocytic cutaneous neoplasms are grouped as NMSC. The most common of these, basal cell carcinoma, squamous cell carcinoma and actinic keratoses as carcinomas in situ, are increasingly called keratinocyte carcinoma. Today, the pathogenesis and risk factors of NMSC are relatively well understood, which has led to multiple treatment options, the recognition of NMSC as an occupational disease in Germany and a variety of prevention approaches...
November 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28994104/epidemiology-of-keratinocyte-carcinomas-after-organ-transplantation
#20
REVIEW
M M Madeleine, N S Patel, E I Plasmeijer, E A Engels, J N Bouwes Bavinck, A E Toland, A C Green
Keratinocyte carcinoma (KC) is the most common type of cancer among white populations, but it is even more common among solid organ transplant recipients (OTRs). The most frequent histological type of KC among OTRs is cutaneous squamous cell carcinoma (cSCC), followed by basal cell carcinoma, although the reverse is seen in the general population. Metastatic cSCCs are more frequent, and mortality is increased compared with immunocompetent populations. There is strong evidence that the risk of KC among OTRs rises with increasing time after transplantation and older age at transplantation, and that KC is enhanced in those with sun-damaged skin...
October 10, 2017: British Journal of Dermatology
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