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https://www.readbyqxmd.com/read/28736128/the-effect-of-pro-nanolipospheres-pnl-formulation-containing-natural-absorption-enhancers-on-the-oral-bioavailability-of-delta-9-tetrahydrocannabinol-thc-and-cannabidiol-cbd-in-a-rat-model
#1
Irina Cherniakov, Dvora Izgelov, Abraham J Domb, Amnon Hoffman
The lipophilic phytocannabinoids cannabidiol (CBD) and Δ(9)-tetrahydrocannabinol (THC) show therapeutic efficacy in various medical conditions. Both molecules are poorly water soluble and subjected to extensive first pass metabolism in the gastrointestinal tract, leading to a limited oral bioavailability of approximately 9%. We have developed an advanced lipid based Self-Emulsifying Drug Delivery System termed Advanced Pro-NanoLiposphere (PNL) pre-concentrate. The PNL is composed of lipid and emulsifying excipients of GRAS status and are known to increase solubility and reduce Phase I metabolism of lipophilic active compounds...
July 20, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28727383/outcomes-of-miniaturized-percutaneous-nephrolitotomy-in-infants-single-centre-experience
#2
Eyyup Sabri Pelit, Bülent Kati, Cengiz Çanakci, Süleyman Sağir, Halil Çiftçi
OBJECTIVES: The present study was aim to evaluate the safety and efficacy of Mini-PNL to treat kidney stones in patients aged <3 years. This is the one of the largest series in the literature in this age group of patients. MATERIAL AND METHODS: From May 2012 to April 2016, the medical records of 74 infant patients who underwent mini-PNL for renal stones were reviewed retrospectively. All infants were evaluated with the plain abdominal radiograph, urinary ultrasound, noncontrast computerized tomography and/or intravenous urogram...
July 20, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28720362/case-discussion-kidney-stone-in-a-patient-with-an-ileal-conduit
#3
Cesare Marco Scoffone, Cecilia Maria Cracco
Kidney stones in patients with ileal conduit and multiple sclerosis are secondary to postoperative anatomical changes and ascending urinary tract infections by urea-splitting bacteria. PNL is the preferred treatment option in patients with urinary diversion and infectious renal stones.
February 2017: European Urology Focus
https://www.readbyqxmd.com/read/28717540/totally-tubeless-percutaneous-nephrolithotomy-is-feasible-in-morbidly-obese-patients
#4
Seyed Mohammad Kazem Aghamir, Mohammad Ghasem Mohseni, Seyed Reza Hosseini, Alborz Salavati, Hossein Ganjali, Mohammad Ali Fallah, Hamed Rezaei, Seyed Saeed Modaresi
OBJECTIVE: Regarding technical difficulties that obese body habitus might impose to percutaneous nephrolithotomy (PNL) success and higher risk of peri-operative complications in this group of patients, we decided to retrospectively gather data from our patients during past 8 years to determine the stone free and complication rates. MATERIAL AND METHODS: Between January 2007-December 2015, seventy-eight obese patients with body mass index over 35 who had indication for PNL including stones larger than 2 cm in pelvi-calyceal system or smaller extracorporeal shock wave lithotripsy (ESWL) resistant stones or who were not a fit candidate for ESWL due to increased skin to target distance, with no contraindication of PNL (including bleeding diathesis, inability to be positioned in prone) were enrolled...
June 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28695419/implementation-of-minimally-invasive-percutaneous-nephrolithotomy-mip-comparison-of-the-initial-learning-curve-with-the-later-on-clinical-routine-in-a-tertiary-centre
#5
T Bergmann, T R W Herrmann, Th Schiller, U Zimmermann, M Burchardt
OBJECTIVE: We report on the comparison of clinical results of the early phase of implementation of minimally invasive PNL (MIP) in a mentor-based approach with the later on clinical routine in a tertiary centre. PATIENTS AND METHODS: From January 2010 until January 2015 MIP was performed in 190 patients. Stone and patient characteristics were recorded in prospective manner. Perioperative complications were recorded within the Clavien-Classification. The first 120 consecutive patients undergoing MIP were evaluated and divided into three groups of 40 patients each...
July 10, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28670669/primary-report-of-totally-tubeless-percutaneous-nephrolithotomy-despite-pelvi-calyceal-perforations
#6
Seyed Mohammad Kazem Aghamir, Alborz Salavati, Morteza Hamidi, Asghar FallahNejad
PURPOSE: Nephrostomy tube insertion and/or a ureteral stent placement is advised when pelvi-calyceal perforations are encountered during percutaneous nephrolithotomy (PNL) nevertheless totally tubeless PNL is a possible exit strategy in percutaneous renal surgery therefore case series on the short term clinical outcomes of noninvasive management of iatrogenic pelvicalyceal perforations encountered during PNL is presented. PATIENTS AND METHODS: During retrospective analysis of 1271 PNL procedures, 25 incidents of accidental ureteral catheter/ jj stent dislodgement during first 24 post-operative hours were identified in patient who had pelvi calyceal perforations and had no nephrostomy tube (tubeless)...
July 2, 2017: Urology Journal
https://www.readbyqxmd.com/read/28658843/anatrophic-nephrolithotomy-in-the-management-of-large-staghorn-calculi-a-single-centre-experience
#7
Ramaiah Keshavamurthy, Vilvapathy Senguttuvan Karthikeyan, Ashwin Mallya, Jayaram Sreenivas, Girish Gurubasappa Nelivigi, Ananth Janarthan Kamath
INTRODUCTION: With advances in endourology, open stone surgery for staghorn calculi has markedly diminished. Anatrophic Nephrolithotomy (AN) is performed for complex staghorn stones which cannot be cleared by a reasonable number of Percutaneous Nephrolithotomy (PNL) attempts. AIM: To assess the indications and outcomes of AN in the modern era. MATERIALS AND METHODS: Between April 2008 and July 2015, AN was done in 14 renal units in 13 patients...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28647973/-study-on-the-immunization-status-and-its-influencing-factors-among-workers-from-the-polio-network-laboratories-in-china
#8
Y S Guo, J Q Wang, C Xu, Y N Liu, X H He, Q Wei
Objective: To Investigate the immune status and influencing factors of provincial polio network laboratory (PNL) workers in China so as to provide evidence for the development of related strategies to protect personnel working at the PNLs. Methods: All the practitioners from the PNLs at the provincial centers for disease control, were selected as objects for this study, from October to December, 2016, under a questionnaire survey. Information on status of immunity and influencing factors was collected, with SAS software, trend chi-square used for statistics analysis...
June 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28646306/evaluation-of-stone-volume-distribution-in-renal-collecting-system-as-a-predictor-of-stone-free-rate-after-percutaneous-nephrolithotomy-a-retrospective-single-center-study
#9
Hasan Anıl Atalay, Lutfi Canat, Recep Bayraktarlı, Ilter Alkan, Osman Can, Fatih Altunrende
We analyzed our stone-free rates of PNL with regard to stone burden and its ratio to the renal collecting system volume. Data of 164 patients who underwent PNL were analyzed retrospectively. Volume segmentation of renal collecting system and stones were done using 3D segmentation software with the images obtained from CT data. Analyzed stone volume (ASV) and renal collecting system volume (RCSV) were measured and the ASV-to-RCSV ratio was calculated after the creation of a 3D surface volume rendering of renal stones and the collecting system...
June 23, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28645773/abc-protein-cgabcf2-is-required-for-asexual-and-sexual-development-appressorial-formation-and-plant-infection-in-colletotrichum-gloeosporioides
#10
Zongshan Zhou, Jianyuan Wu, Meiyu Wang, Junxiang Zhang
ATP-binding cassette (ABC) proteins are exclusively found in both prokaryotes and eukaryotes. In this study, we have characterized a gene from Glomerella leaf spot pathogen Colletotrichum gloeosporioides that encodes an ABC protein, whose function to date remains unknown. We designated this gene as CgABCF2. Deletion of CgABCF2 showed drastic reduction both growing rate and conidial production in C. gloeosporioides. The Δcgabcf2 mutant did not form the appressoria, lost the capability to infect apple and failed to form lesions on the wounded leaves and fruits...
June 20, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28634113/vitamin-d3-supplementation-attenuates-the-early-stage-of-mouse-hepatocarcinogenesis-promoted-by-hexachlorobenzene-fungicide
#11
Guilherme R Romualdo, Renata L Goto, Ana A H Fernandes, Bruno Cogliati, Luis F Barbisan
Hexachlorobezene (HCB), a fungicide widely distributed in the environment, promotes the development of hepatocellular preneoplastic lesions (PNL) and tumors in rodents. In contrast, vitamin D3 (VD3) supplementation presents a potential role for the prevention/treatment of chronic liver diseases. Thus, we investigated whether VD3 supplementation attenuates the early stage of HCB-promoted hepatocarcinogenesis. Female Balb/C mice were injected a single dose of diethylnitrosamine (DEN, 50 mg/kg) at postnatal day 15...
June 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28631903/-solitary-stones-of-the-lower-renal-calyx-how-to-treat
#12
A G Martov, D V Ergakov, A S Andronov, S V Dutov, R A Takhaev, Z I Kil'chukov, S A Moskalenko
INTRODUCTION: The choice of treatment for the stones of the lower renal calyx is one of the challenging issues of modern urology. The aim of this retrospective and prospective study was to investigate the clinical effectiveness and safety of 3 modern minimally invasive techniques for treating renal stones: percutaneous (PNL) and transurethral (TNL) nephrolithotripsy and extracorporeal shock wave lithotripsy (ESWL) in patients with solitary lower calyx stones sized from 10 to 15 mm. MATERIALS AND METHODS: The study included 136 patients with symptomatic stones of the lower calyces, who underwent ESWL, PNL and TNL from November 2010 to the present day...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28613206/-evolution-from-percutaneous-nephrolithotomy-to-mini-pcnl-in-supine-position-on-the-treatment-of-complex-renal-calculi-feasibility-study
#13
Fernando Ramón de Fata-Chillón, Helena Gimbernat-Díaz, Cristina Redondo-Redondo, Elisa Meilán-Hernández, Erika Mateo-Martínez
OBJECTIVES: Mini-PCNL is a potentially less invasive technique than standard percutaneous nephrolithotomy (PCNL). We present our experience and results comparing both approaches in large burden complex renal calculi. METHODS: Prospective non randomized study comparing PCNL (24/26F nephroscope; Group A) and Mini-PCNL (15/18F; Group B) perioperative and postoperative results, in 40 (20 each group) consecutive patients between 2013 and 2014. We analyze demographic data, hemoglobin drop, urine culture, stone characteristics, operative time, puncture, number and size of the tract, disintegration energy sources, nephrostomy placement, hospital stay, stone free rate and Clavien-Dindo complications...
June 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28567327/robot-assisted-laparoscopic-management-of-caliceal-diverticular%C3%A2-calculi
#14
Anneleen Verbrugghe, Loïc Gaillandre, Damien Mouton, Franck Deschildre, Philippe Koenig, Charles Ballereau, Pierre Colin
Standard treatment modalities of caliceal diverticular calculi range from extracorporal shockwave lithotripsy (SWL) over retrograde intrarenal surgery (RIRS), percutaneous nephrolithotomy (PNL) and laparoscopic stone removal. A 55-year-old woman presented with a history of pyelonephritis based on a caliceal diverticular calculus. Due to the narrow infundibulum and anterior location, a robot-assisted laparoscopic calicotomy with extraction of the calculi and fulguration of the diverticulum was performed, with no specific perioperative problems and good stone-free results...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28560507/comparison-of-croes-s-t-o-n-e-and-guy-s-scoring-systems-for-the-prediction-of-stone-free-status-and-complication-rates-following-percutaneous-nephrolithotomy-in-patients-with-chronic-kidney-disease
#15
Fatih Yanaral, Faruk Ozgor, Metin Savun, Murat Sahan, Omer Sarilar, Murat Binbay
PURPOSE: To evaluate and compare the accuracy of S.T.O.N.E, Clinical Research Office of the Endourological Society (CROES), and Guy's stone score in patients with chronic kidney disease (CKD) following percutaneous nephrolithotomy (PNL). METHODS: The charts of patients who had undergone a prone percutaneous nephrolithotomy from June 2006 to June 2016 were retrospectively analyzed. Patients accepted as stage 3 and higher according to chronic kidney disease epidemiology collaboration formula, were enrolled into the study...
May 30, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28544506/photocatalytic-nanosheet-lithography-photolithography-based-on-organically-modified-photoactive-2d-nanosheets
#16
Pirmin Ganter, Bettina V Lotsch
Harvesting the properties of nanosheets is not only crucial from a fundamental perspective, but also for the development of novel functional devices based on 2D nanosheets. Herein, we demonstrate the processing of organically modified TBAx H1-x Ca2 Nb3 O10 nanosheets into photonic thin films and study their colorimetric sensing properties in response to various aqueous and organic solvent vapors. Building on the enhanced solvent accessibility of TBA-containing nanosheets and their photocatalytic activity under UV irradiation, we develop a new concept for photocatalytic lithography using TBAx H1-x Ca2 Nb3 O10 nanosheets as a negative photoresist to obtain high-fidelity micron-scale patterns of robust inorganic nanosheets...
May 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28537701/effects-of-body-mass-index-on-the-outcomes-of-percutaneous-nephrolithotomy
#17
Cemal Selcuk Isoglu, Tufan Suelozgen, Hayal Boyacioglu, Gokhan Koc
OBJECTIVE: To examine the the effect of body mass index (BMI) on PNL results and complications with a large number of patients. MATERIALS AND METHODS: A total of 958 patients were included in the study, who underwent percutaneous nephrolithotomy in our clinic between 2008 and 2015. Patients were divided into 2 groups according to their body mass index. Patients with a BMI < 30 kg/m2 were classified as group 1 (n:676) and patients with a BMI ≥ 30 kg/m2 were classified as group 2 (n:282)...
May 23, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28523365/outcome-from-5-year-live-surgical-demonstrations-in-urinary-stone-treatment-are-outcomes-compromised
#18
Jaap D Legemate, Stefano P Zanetti, Joyce Baard, Guido M Kamphuis, Emanuele Montanari, Olivier Traxer, Jean Jmch de la Rosette
PURPOSE: To compare intra- and post-operative outcomes of endourological live surgical demonstrations (LSDs) and routine surgical practice (RSP) for urinary stones. METHODS: Consecutive ureterorenoscopic (URS) and percutaneous (PNL) urinary stone procedures over a 5-year period were reviewed. Procedures were divided into LSDs and RSP. Differences between the groups were separately analysed for URS and PNL. Primary outcomes included intra- and post-operative complication rates and grades...
May 18, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28498511/enhanced-antitumor-effect-of-targeted-nanoliposomal-bleomycin
#19
Mohsen Chiani, Kayhan Azadmanesh, Mohammad Ali Shokrgozar, Mohammad Reza Mehrabi, Azim Akbarzadeh, Dariush Norouzian
Folate receptor (FR)-mediated drug delivery is a promising approach for active targeting of drugs to the FR-positive tumor cells. Bleomycin (BLM) is an antitumor antibiotic with poor therapeutic activity as a result of its limited diffusion into tumor cells. The aim of this study was to investigate whether FR-targeted PEGylated nanoliposomes (FPNL) can effectively deliver BLM to tumor cells and enhance its in vitro and in vivo efficacy. FPNL and PNL (non-targeted) were prepared by thin film hydration method, and their physiochemical properties, cellular uptake, tissue distribution and tumor inhibitory effects were investigated...
May 12, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28359409/surgical-management-of-urinary-stones-with-abnormal-kidney-anatomy
#20
Giray Ergin, Mustafa Kirac, Ali Unsal, Burak Kopru, Mustafa Yordam, Hasan Biri
In spite of the fact that urologic surgical techniques used by urologists are becoming more and more minimally invasive and easier because of developing technologies, surgical approaches for the urinary stones in kidneys with abnormal anatomy are still confusing. The objective of this article is to determine the treatment options in these kidneys. For this purpose, between 2005 and 2015, we retrospectively evaluated patients operated for urolithiasis with various congenital renal anomalies in five referral urology clinics in our country...
April 2017: Kaohsiung Journal of Medical Sciences
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