keyword
https://read.qxmd.com/read/38510140/a-collagen10a1-mutation-disrupts-cell-polarity-in-a-medaka-model-for-metaphyseal-chondrodysplasia-type-schmid
#21
JOURNAL ARTICLE
Wen Hui Tan, Martin Rücklin, Daria Larionova, Tran Bich Ngoc, Bertie Joan van Heuven, Federica Marone, Paul Matsudaira, Christoph Winkler
Heterozygous mutations in COL10A1 lead to metaphyseal chondrodysplasia type Schmid (MCDS), a skeletal disorder characterized by epiphyseal abnormalities. Prior analysis revealed impaired trimerization and intracellular retention of mutant collagen type X alpha 1 chains as cause for elevated endoplasmic reticulum (ER) stress. However, how ER stress translates into structural defects remained unclear. We generated a medaka ( Oryzias latipes ) MCDS model harboring a 5 base pair deletion in col10a1 , which led to a frameshift and disruption of 11 amino acids in the conserved trimerization domain...
April 19, 2024: IScience
https://read.qxmd.com/read/38508990/metabolomics-of-human-umbilical-vein-endothelial-cell-based-analysis-of-the-relationship-between-hyperuricemia-and-dyslipidemia
#22
JOURNAL ARTICLE
Wen Huang, Min Zhang, Qiong Qiu, Jing Zhang, Chao Hua, Geliang Chen, Hua Xie
BACKGROUND AND AIMS: Hyperuricemia frequently accompanies dyslipidemia, yet the precise mechanism remains elusive. Leveraging cellular metabolomics analyses, this research probes the potential mechanisms wherein hyperuricemia provokes endothelial cell abnormalities, inducing disordered bile metabolism and resultant lipid anomalies. METHODS AND RESULTS: We aimed to identify the differential metabolite associated with lipid metabolism through adopting metabolomics approach, and thereafter adequately validating its protective function on HUVECs by using diverse assays to measure cellular viability, reactive oxygen species, migration potential, apoptosis and gene and protein levels of inflammatory factors...
February 7, 2024: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://read.qxmd.com/read/38508549/along-the-microbiota-gut-brain-axis-use-of-plant-polysaccharides-to-improve-mental-disorders
#23
REVIEW
Jiayu Gao, Ying Liang, Pu Liu
With the development of gut microbiota-specific interventions for mental disorders, the interactions between plant polysaccharides and microbiota in the intestinal and their consequent effects are becoming increasingly important. In this review, we discussed the role of plant polysaccharides in improving various mental disorders via the microbiota-gut-brain axis. The chemical and structural characteristics and metabolites of these plant polysaccharides were summarised. Plant polysaccharides and their metabolites have great potential for reshaping gut microbiota profiles through gut microbiota-dependent fermentation...
March 18, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38508478/study-on-the-correlation-between-serum-indole-3-propionic-acid-levels-and-the-progression-and-prognosis-of-acute-ischemic-stroke
#24
JOURNAL ARTICLE
Xiaobo Li, Danni Chen, Xin Chen, Chao Jiang, Yiming Guo, Jing Hang, Luhang Tao, Yuping Li, Hailong Yu
OBJECTIVE: This study aimed to explore the correlation between the serum level of indole-3-propionic acid (IPA) and the progression and prognosis of acute cerebral infarction (ACI). METHODS: This study enrolled 197 patients with ACI, and 53 participants from a community-based stroke screening program during the same period were included as the control group. The patients with ACI were divided into quartiles of serum IPA. A logistic regression model was used for comparison...
March 18, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38508432/investigating-the-mechanism-of-cornel-iridoid-glycosides-on-type-2-diabetes-mellitus-using-serum-and-urine-metabolites-in-rats
#25
JOURNAL ARTICLE
Yadi Hou, Yanmei Huang, Zihui Shang, Shichao Ma, Tianyi Cui, Ali Chen, Yongxia Cui, Suiqing Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Cornel iridoid glycosides (CIG) are extracted from Corni fructus, a herbal medicine used in traditional Chinese medicine to treat diabetes. However, the antidiabetic effects of CIG and the underlying metabolic mechanisms require further exploration. AIM OF THE STUDY: This study aimed to assess the antidiabetic effects and metabolic mechanism of CIG by performing metabolomic analyses of serum and urine samples of rats. MATERIALS AND METHODS: A rat model of type 2 diabetes mellitus (T2DM) was established by administering a low dose of streptozotocin (30 mg/kg) intraperitoneally after 4 weeks of feeding a high-fat diet...
March 18, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38508188/epigenomic-tomography-for-probing-spatially-defined-chromatin-state-in-the-brain
#26
JOURNAL ARTICLE
Zhengzhi Liu, Chengyu Deng, Zirui Zhou, Ya Xiao, Shan Jiang, Bohan Zhu, Lynette B Naler, Xiaoting Jia, Danfeng Daphne Yao, Chang Lu
Spatially resolved epigenomic profiling is critical for understanding biology in the mammalian brain. Single-cell spatial epigenomic assays were developed recently for this purpose, but they remain costly and labor intensive for examining brain tissues across substantial dimensions and surveying a collection of brain samples. Here, we demonstrate an approach, epigenomic tomography, that maps spatial epigenomes of mouse brain at the scale of centimeters. We individually profiled neuronal and glial fractions of mouse neocortex slices with 0...
March 13, 2024: Cell Rep Methods
https://read.qxmd.com/read/38507972/hybrid-molecules-synergistically-mitigate-ferroptosis-and-amyloid-associated-toxicities-in-alzheimer-s-disease
#27
JOURNAL ARTICLE
Dikshaa Padhi, Prayasee Baruah, Madhu Ramesh, Hariharan Moorthy, Thimmaiah Govindaraju
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the build-up of extracellular amyloid β (Aβ) plaques and intracellular neurofibrillary tangles (NFTs). Ferroptosis, an iron (Fe)-dependent form of cell death plays a significant role in the multifaceted AD pathogenesis through generation of reactive oxygen species (ROS), mitochondrial damage, lipid peroxidation, and reduction in glutathione peroxidase 4 (GPX4) enzyme activity and levels. Aberrant liquid-liquid phase separation (LLPS) of tau drives the growth and maturation of NFTs contributing to AD pathogenesis...
March 11, 2024: Redox Biology
https://read.qxmd.com/read/38507200/discovery-and-characterization-of-linear-motif-mediated-protein-protein-complexes
#28
JOURNAL ARTICLE
András Zeke, Anita Alexa, Attila Reményi
There are myriads of protein-protein complexes that form within the cell. In addition to classical binding events between globular domains, many protein-protein interactions involve short disordered protein regions. The latter contain so-called linear motifs binding specifically to ordered protein domain surfaces. Linear binding motifs are classified based on their consensus sequence, where only a few amino acids are conserved. In this chapter we will review experimental and in silico techniques that can be used for the discovery and characterization of linear motif mediated protein-protein complexes involved in cellular signaling, protein level and gene expression regulation...
2024: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/38504475/blood-gases-acid-base-and-metabolic-alterations-in-calves-with-bronchopneumonia-diagnosed-via-clinical-signs-and-thoracic-ultrasonography-a-cross-sectional-study
#29
JOURNAL ARTICLE
Antonio Boccardo, Vincenzo Ferrulli, Giulia Sala, Donatella Scavone, Saverio Paltrinieri, Laura Filippone Pavesi, Davide Pravettoni
BACKGROUND: Bronchopneumonia (BP) in calves potentially causes systemic changes. OBJECTIVES: To describe metabolic, arterial blood gas, and acid-base disorders in calves with BP diagnosed by thoracic ultrasound (TUS), Wisconsin score (WISC), and combinations of WISC and TUS. ANIMALS: Two hundred thirty-one dairy preweaned dairy calves from 13 dairy farms. METHODS: Cross-sectional study. Each calf sequentially underwent arterial blood gas evaluation, WISC score, venous sampling, and TUS...
March 19, 2024: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/38504410/tolerance-development-in-cow-s-milk-allergic-children-receiving-amino-acid-based-formula-with-synbiotics-36-months-follow-up-of-a-randomized-controlled-trial-presto-study
#30
JOURNAL ARTICLE
Pantipa Chatchatee, Anna Nowak-Wegrzyn, Lars Lange, Suwat Benjaponpitak, Kok W Chong, Pasuree Sangsupawanich, Simone R B M Eussen, Marleen T J van Ampting, Manon M Oude Nijhuis, Jane E Langford, Valerie Trendelenburg, Robert Pesek, Carla M Davis, Antonella Muraro, Michel Erlewyn-Lajeunesse, Adam T Fox, Louise J Michaelis, Kirsten Beyer
The objective of the present study is to assess the rates of acquired tolerance to cow's milk (CM) after 36 months in subjects who consumed amino acid-based formula with synbiotics (AAF-S) or amino acid-based formula without synbiotics (AAF) during a 1-year intervention period in early life as part of the PRESTO study (Netherlands Trial Register number NTR3725). Differences in CM tolerance development between groups were analysed using a logistic regression model. Results show that the proportion of subjects (mean [±SD] age, 3...
March 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38504022/the-potential-renal-acid-load-of-plant-based-meat-alternatives
#31
JOURNAL ARTICLE
Julian Herter, Roman Huber, Maximilian Andreas Storz
Plant-based meat alternatives (PBMAs) are food products derived from plants and designed to mimic the preparation methods, nutritional profile, and sensorial qualities of meat. PBMAs are currently subject to a controversial debate concerning their health value. Here, we reviewed PBMAs' potential renal acid load (PRAL). The PRAL is an estimate for the amount of acid or base a certain food produces in the human body, and was associated with tissue damage and acid stress. PRAL values varied substantially across the examined foods, and differences were as large as 19...
March 19, 2024: European Journal of Clinical Nutrition
https://read.qxmd.com/read/38503376/the-disordered-extracellular-matrix-landscape-induced-endometrial-fibrosis-of-sheep-a-multi-omics-integrative-analysis
#32
JOURNAL ARTICLE
Tingting Chu, Jiuzeng Cui, Lei Sun, Xiaoyu Zhang, Le Sun, Jiashun Tong, Long Li, Yuhang Xiao, Liang Xu, Lei Zhang, Yuxuan Song
Endometrial fibrosis leads to the destruction of endometrial function and affects reproductive performance. However, mechanisms underlying the development of endometrial fibrosis in sheep remain unclear. We use transcriptomic, proteomic, and metabolomic studies to reveal the formation mechanisms of endometrial fibrosis. The results showed that the fibrotic endometrial tissue phenotype presented fewer glands, accompanied by collagen deposition. Transcriptomic results indicated alterations in genes associated with the synthesis and degradation of extracellular matrix components, which alter metabolite homeostasis, especially in glycerophospholipid metabolism...
March 17, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38503362/pathophysiology-and-management-of-enteric-hyperoxaluria
#33
REVIEW
Jordan Desenclos, Valentine Forté, Cécile Clément, Michel Daudon, Emmanuel Letavernier
Enteric hyperoxaluria is a metabolic disorder resulting from conditions associated with fatty acid malabsorption and characterized by an increased urinary output of oxalate. Oxalate is excessively absorbed in the gut and then excreted in urine where it forms calcium oxalate crystals, inducing kidney stones formation and crystalline nephropathies. Enteric hyperoxaluria is probably underdiagnosed and may silently damage kidney function of patients affected by bowel diseases. Moreover, the prevalence of enteric hyperoxaluria has increased because of the development of bariatric surgical procedures...
March 17, 2024: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/38501707/clinical-metabolomics-characteristics-of-diabetic-kidney-disease-a-meta-analysis-of-1875-cases-with-diabetic-kidney-disease-and-4503-controls
#34
JOURNAL ARTICLE
Yu Yuan, Liping Huang, Lulu Yu, Xingxu Yan, Siyu Chen, Chenghao Bi, Junjie He, Yiqing Zhao, Liu Yang, Li Ning, Hua Jin, Rongrong Yang, Yubo Li
AIMS: Diabetic Kidney Disease (DKD), one of the major complications of diabetes, is also a major cause of end-stage renal disease. Metabolomics can provide a unique metabolic profile of the disease and thus predict or diagnose the development of the disease. Therefore, this study summarises a more comprehensive set of clinical biomarkers related to DKD to identify functional metabolites significantly associated with the development of DKD and reveal their driving mechanisms for DKD. MATERIALS AND METHODS: We searched PubMed, Embase, the Cochrane Library and Web of Science databases through October 2022...
March 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38498568/from-primary-data-to-ethnopharmacological-investigations-on-achillea-erba-rotta-subsp-moschata-wulfen-i-richardson-as-a-remedy-against-gastric-ailments-in-valmalenco-italy
#35
JOURNAL ARTICLE
Martina Bottoni, Giulia Martinelli, Nicole Maranta, Emanuela Sabato, Fabrizia Milani, Lorenzo Colombo, Paola Sira Colombo, Stefano Piazza, Enrico Sangiovanni, Claudia Giuliani, Piero Bruschi, Giulio Vistoli, Mario Dell'Agli, Gelsomina Fico
(1) Background: Within the framework of the European Interreg Italy-Switzerland B-ICE & Heritage project (2018-2022), this study originated from a three-year ethnobotanical survey in Valmalenco (Sondrio, Italy). Following a preliminary work published by our group, this research further explored the folk therapeutic use of Achillea erba-rotta subsp. moschata (Wulfen) I.Richardson (Asteraceae) for dyspepsia disorders, specifically its anti-inflammatory potential at a gastrointestinal level. (2) Methods: Semi-structured interviews were performed...
February 16, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38497797/clinical-biomarker-and-research-tests-among-us-government-personnel-and-their-family-members-involved-in-anomalous-health-incidents
#36
JOURNAL ARTICLE
Leighton Chan, Mark Hallett, Chris K Zalewski, Carmen C Brewer, Cris Zampieri, Michael Hoa, Sara M Lippa, Edmond Fitzgibbon, Louis M French, Anita D Moses, André J van der Merwe, Carlo Pierpaoli, L Christine Turtzo, Simge Yonter, Pashtun Shahim, Brian Moore, Lauren Stamps, Spencer Flynn, Julia Fontana, Swathi Tata, Jessica Lo, Mirella A Fernandez, Annie-Lori Joseph, Jesse Matsubara, Julie Goldberg, Thuy-Tien D Nguyen, Noa Sasson, Justine Lely, Bryan Smith, Kelly A King, Jennifer Chisholm, Julie Christensen, M Teresa Magone, Chantal Cousineau-Krieger, Rakibul Hafiz, Amritha Nayak, Okan Irfanoglu, Sanaz Attaripour, Chen Lai, Wendy B Smith
IMPORTANCE: Since 2015, US government and related personnel have reported dizziness, pain, visual problems, and cognitive dysfunction after experiencing intrusive sounds and head pressure. The US government has labeled these anomalous health incidents (AHIs). OBJECTIVE: To assess whether participants with AHIs differ significantly from US government control participants with respect to clinical, research, and biomarker assessments. DESIGN, SETTING, AND PARTICIPANTS: Exploratory study conducted between June 2018 and July 2022 at the National Institutes of Health Clinical Center, involving 86 US government staff and family members with AHIs from Cuba, Austria, China, and other locations as well as 30 US government control participants...
March 18, 2024: JAMA
https://read.qxmd.com/read/38496672/local-patterns-of-genetic-sharing-challenge-the-boundaries-between-neuropsychiatric-and-insulin-resistance-related-conditions
#37
Giuseppe Fanelli, Barbara Franke, Chiara Fabbri, Josefin Werme, Izel Erdogan, Ward De Witte, Geert Poelmans, I Hyun Ruisch, Lianne Maria Reus, Veerle van Gils, Willemijn J Jansen, Stephanie J B Vos, Kazi Asraful Alam, Aurora Martinez, Jan Haavik, Theresa Wimberley, Søren Dalsgaard, Ábel Fóthi, Csaba Barta, Fernando Fernandez-Aranda, Susana Jimenez-Murcia, Simone Berkel, Silke Matura, Jordi Salas-Salvadó, Martina Arenella, Alessandro Serretti, Nina Roth Mota, Janita Bralten
UNLABELLED: The co-occurrence of insulin resistance (IR)-related metabolic conditions with neuropsychiatric disorders is a complex public health challenge. Evidence of the genetic links between these phenotypes is emerging, but little is currently known about the genomic regions and biological functions that are involved. To address this, we performed Local Analysis of [co]Variant Association (LAVA) using large-scale (N=9,725-933,970) genome-wide association studies (GWASs) results for three IR-related conditions (type 2 diabetes mellitus, obesity, and metabolic syndrome) and nine neuropsychiatric disorders...
March 8, 2024: medRxiv
https://read.qxmd.com/read/38496614/prevalent-fast-evolution-of-genes-involved-in-heterochromatin-functions
#38
Leila Lin, Yuheng Huang, Jennifer McIntyre, Ching-Ho Chang, Serafin Colmenares, Yuh Chwen G Lee
Heterochromatin is a gene-poor and repeat-rich genomic compartment ubiquitously found in eukaryotes. Despite its low transcriptional activity, heterochromatin plays important roles in maintaining genome stability, organizing chromosomes, and suppressing transposable elements (TEs). Given the importance of these functions, it is expected that the genes involved in heterochromatin regulation would be highly conserved. Yet, a handful of these genes have been found to evolve rapidly. To investigate whether these previous findings are anecdotal or general to genes modulating heterochromatin, we compiled an exhaustive list of 106 candidate genes involved in heterochromatin functions and investigated their evolution over both short and long evolutionary time scales in Drosophila...
March 6, 2024: bioRxiv
https://read.qxmd.com/read/38494585/research-progress-of-astragaloside-iv-in-treating-acute-kidney-injury
#39
REVIEW
Yu Liu, Youqun Huang, Dongxuan Sun, Naijing Ye, Tong Chen, Mengfan Yang, Li Zhou, Hequn Zou
Acute kidney injury (AKI) is one of the most common clinical critical illnesses, with decreased glomerular filtration rate, retention of nitrogen products, water and electrolyte disorders, and acid-base imbalance as the main clinical manifestations. Presently, there is no effective treatment for acute kidney injury, but the main treatment is to cure the primary disease, remove risk factors, maintain acid-base and water-electrolyte balance, and undergo kidney replacement. However, the mortality rate is still high...
March 18, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38488112/microbiome-and-its-impact-on-fetal-and-neonatal-brain-development-current-opinion-in-pediatrics
#40
JOURNAL ARTICLE
Nina M Frerichs, Tim G J de Meij, Hendrik J Niemarkt
PURPOSE OF REVIEW: Emerging evidence suggests that the gut microbiota and its metabolites regulate neurodevelopment and cognitive functioning via a bi-directional communication system known as the microbiota-gut-brain axis (MGBA). RECENT FINDINGS: The MGBA influences brain development and function via the hypothalamic-pituitary axis, the vagal nerve, immune signaling, bacterial production of neurotransmitters, and microbial metabolites like short-chain fatty acids, tryptophan derivatives, and bile acids...
March 11, 2024: Current Opinion in Clinical Nutrition and Metabolic Care
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