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Induction of labor

Jumpei F Yamagishi, Nen Saito, Kunihiko Kaneko
As cells grow and divide under a given environment, they become crowded and resources are limited, as seen in bacterial biofilms and multicellular aggregates. These cells often show strong interactions through exchanging chemicals, as evident in quorum sensing, to achieve mutualism and division of labor. Here, to achieve stable division of labor, three characteristics are required. First, isogenous cells differentiate into several types. Second, this aggregate of distinct cell types shows better growth than that of isolated cells without interaction and differentiation, by achieving division of labor...
October 2016: PLoS Computational Biology
Hatice Kansu-Celik, Ozlem Gun-Eryılmaz, Nasuh Utku Dogan, Seval Haktankaçmaz, Mehmet Cinar, Saynur Sarici Yilmaz, Cavidan Gülerman
BACKGROUND: We aimed to evaluate the efficacy and safety of dinoprostone for cervical ripening and labor induction in patients with term oligohydramnios and Bishop score ≤ 5. METHODS: This was a prospective case-control study, which included 104 consecutive women with a Bishop score≤5. Participants were divided into two groups. Women with term isolated oligohydramnios and Bishop score≤5 underwent induction of labor with a vaginal insert containing 10-mg timed-release dinoprostone (prostaglandin E2; Group A, n=40)...
October 10, 2016: Journal of the Chinese Medical Association: JCMA
Heléne E K Sundelin, Olof Stephansson, Kari Johansson, Jonas F Ludvigsson
INTRODUCTION: An increased risk of preterm birth in women with Joint Hypermobility Syndrome (JHS) or Ehlers-Danlos Syndrome (EDS) is suspected. MATERIAL AND METHODS: In this nationwide cohort study from 1997 through 2011, women with either JHS or EDS or both disorders were identified through the Swedish Patient Register, and linked to the Medical Birth Register. Thereby 314 singleton births to women with JHS/EDS before delivery were identified. These births were compared with 1,247,864 singleton births to women without a diagnosis of JHS/EDS...
October 14, 2016: Acta Obstetricia et Gynecologica Scandinavica
Lynn M Yee, Grecio Sandoval, Jennifer Bailit, Uma M Reddy, Ronald J Wapner, Michael W Varner, Steve N Caritis, Mona Prasad, Alan T N Tita, George Saade, Yoram Sorokin, Dwight J Rouse, Sean C Blackwell, Jorge E Tolosa
OBJECTIVE: To describe factors associated with delayed pushing and evaluate the relationship between delayed pushing and perinatal outcomes in nulliparous women with singleton term gestations. METHODS: This was a secondary analysis of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Assessment of Perinatal Excellence cohort of 115,502 women and their neonates born in 25 U.S. hospitals from 2008 to 2011. Nulliparous women with singleton, cephalic, nonanomalous term births who achieved 10-cm cervical dilation were included...
October 6, 2016: Obstetrics and Gynecology
Romana Furrer, Katharina Winter, Leonhard Schäffer, Roland Zimmermann, Tilo Burkhardt, Christian Haslinger
OBJECTIVE: To evaluate postpartum blood loss in women with treated intrahepatic cholestasis of pregnancy. METHODS: In a retrospective case-control study, 15,083 deliveries including 348 women with intrahepatic cholestasis of pregnancy (2.3%) were analyzed from 2004 to 2014. To adjust for differences in baseline characteristics, a propensity analysis was performed and women in the control group were matched to the women in the intrahepatic cholestasis of pregnancy group in a 5:1 ratio...
October 6, 2016: Obstetrics and Gynecology
Amy C Hermesch, Amanda A Allshouse, Kent D Heyborne
OBJECTIVE: To investigate the relationship between body mass index (BMI) and the onset of parturition throughout gestation. METHODS: This was a secondary analysis of the Maternal-Fetal Medicine Units Network Preterm Prediction Study. Time-to-spontaneous-birth-event (ie, "survival") methods were used to study the association of BMI with the timing of spontaneous onset of labor throughout gestation with indicated births censored at delivery. A Kaplan-Meier estimate of the probability of spontaneous labor was compared with a log rank test across five categories of BMI (kg/m): underweight (less than 18...
October 6, 2016: Obstetrics and Gynecology
Dilek Ulubaş-Işık, Sara Erol, Nihal Demirel, Yusuf Kale, İstemi Han Çelik, Ömer Lütfi Tapısız, Bülent Yırcı, Ahmet Yağmur Baş
Early-term infants incur higher risks for neonatal morbidities compared to full-term infants. In this study, we investigated the neonatal morbidities in early-term infants admitted to a neonatal intensive care unit (NICU). Early-term (37 0/7 and 38 6/7 weeks of gestation) and full-term (39 0/7 and 41 6/7 weeks of gestation) infants born between January 2013 and December 2014 were enrolled in this study. Early-term deliveries accounted for 8,026 (25.7%) of all live births (n = 31,170). The admission rate of early-term infants to the NICU was 7...
November 2015: Turkish Journal of Pediatrics
Pedro Hidalgo-Lopezosa, María Hidalgo-Maestre
OBJECTIVE: To assess the risk of uterine rupture (UR) in attempted vaginal birth after cesarean and to identify risk factors. METHODS: Systematic review by consulting the following databases: PubMed (MEDLINE), Cochrane Library Plus, Embase, Nursing@Ovid, Cuidatge and Dialnet. The search was conducted between January and March 2015. MeSH descriptors used were: vaginal birth after cesarean; uterine rupture; labor induced and labor obstetric or trial of labor. There were no restrictions on date or language...
October 7, 2016: Enfermería Clínica
Jennifer K Durst, Akila Subramaniam, Ying Tang, Jeff M Szychowski, Sukhkamal B Campbell, Joseph R Biggio, Lorie M Harper
OBJECTIVE: To evaluate perinatal outcomes in nulliparous women undergoing induction of labor for gestational hypertension at term. STUDY DESIGN: Retrospective cohort study of nulliparous women with gestational hypertension undergoing induction of labor ≥ 37 weeks. Mode of delivery and perinatal outcomes were compared for women who delivered at 37(°-6/7), 38(°-6/7), and ≥ 39(°/7) weeks gestation. RESULTS: The cohort included 320 women: 67 (21%) at 37(°-6/7), 76 (24%) at 38(°-6/7), and 177 (55%) at ≥ 39(°/7)...
October 11, 2016: Journal of Maternal-fetal & Neonatal Medicine
Nada Aracic, Ivica Stipic, Ivana Jakus Alujevic, Petar Poljak, Mario Stipic
AIM: To evaluate the influence of cervical length (CL) and parity as prediction factors for assessment of cesarean section (CS) risk in women with premature rupture of membranes (PROM) at term and unfavorable cervix, undergoing induction of labor (IOL) with dinoprostone intracervical gel. METHODS: A prospective study involved 50 nulliparous and 51 multiparous women admitted for IOL. Pre-induction CL was measured and delivery outcomes were recorded. RESULTS: Nulliparous women were younger than the multiparous (26...
October 8, 2016: Journal of Perinatal Medicine
Wangsheng Wang, Chao Liu, Kang Sun
Rupture of fetal membranes (ROM) can initiate parturition at both term and preterm birth. Apoptosis of the amnion epithelium plays a key role in structural remodeling of the membranes preceding ROM. However, the causative factors for apoptosis remain unidentified. Toward the end of gestation, a feed-forward regeneration of cortisol via 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) exists in the fetal membranes. Here we have examined whether cortisol accumulation is a causative factor for amnion cells apoptosis...
October 3, 2016: Endocrinology
Liran Hiersch, Riki Bergel-Bson, Dorit Asher, Amir Aviram, Rinat Gabby-Benziv, Yariv Yogev, Eran Ashwal
OBJECTIVE: To identify risk factors for post-partum hemorrhage (PPH) following vacuum assisted vaginal delivery (VAVD). STUDY DESIGN: A retrospective study of all women with singleton pregnancies who underwent VAVD in a tertiary hospital (2012-2014). PPH was defined as any of the following: ≥500 ml estimated blood loss, hemoglobin drop ≥3 g/dl (difference between pre- and post-VAVD hemoglobin levels) or the need for blood products transfusion. Characteristics of women with PPH following VAVD were compared to those of women with no PPH following VAVD...
September 29, 2016: Archives of Gynecology and Obstetrics
Serena Simeone, Marianna Pina Rambaldi, Caterina Serena, Serena Ottanelli, Federico Mecacci
INTRODUCTION: MCA and uterine artery Doppler PI are commonly used in the evaluation of IUGR. Targets: This retrospective pilot study aims to investigate whether MCA/UtA ratio may identify adverse outcome in late onset IUGRs. A cohort of 69 pregnancies affected with late IUGR which underwent labor induction according to local protocols was retrospectively revised on the relationship between MCA/UtA ratio at first observation and the following adverse outcomes: cesarean section for nonreassuring fetal status, birthweight (expressed as percentile and continuous values, umbilical artery pH, NICU admission and Apgar score < 7 after 1 and 5 min...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
Eran Hadar, Liran Hiersch, Eran Ashwal, Rony Chen, Arnon Wiznitzer, Rinat Gabbay-Benziv
PURPOSE: Maternal age is an important consideration for antenatal care, labor and delivery. We aimed to evaluate the induction of labor (IoL) failure rates among elderly nulliparous women. MATERIALS AND METHODS: We conducted a retrospective analysis of all nulliparous women at 34 + 0 to 41 + 6 weeks, undergoing cervical ripening by prostaglandin E2 (PGE2) vaginal insert. Study group included elderly (≥35 years) nulliparous and control group included non-elderly (<35 years) nulliparous women...
October 17, 2016: Journal of Maternal-fetal & Neonatal Medicine
A Kacvinska, M Drab, A Totka, K Holoman, M Gabor
OBJECTIVES: To determine the effect of labor induction using prostaglandin, gestation period and delivery type on the cause and extent of birth-canal injuries. METHODS: A retrospective study based on the records of II. GPK UNB Ružinov. The total set (n = 1377) consisted of patients who went into labor in second half of the year 2014 at this clinic. The research used categorical data divided into groups of factors (induction, week of delivery, type of delivery) and birth injuries...
2016: Bratislavské Lekárske Listy
Dimitrios Papoutsis, Angeliki Antonakou, Adam Gornall, Chara Tzavara, Michelle Mohajer
PURPOSE: To develop a risk-assessment model for the prediction of emergency cesarean section (CS) in women having induction of labor (IOL). METHODS: This was an observational cohort study of women with IOL for any indication between 2007 and 2013. Women induced for stillbirths and with multiple pregnancies were excluded. The primary objective was to identify risk factors associated with CS delivery and to construct a risk-prediction tool. RESULTS: 6169 women were identified with mean age of 28...
September 27, 2016: Archives of Gynecology and Obstetrics
R Q Yang, Z Y Liu, J L Zhang, Y Nan, L M Fan
Objective: To investigate the relationship among the prenatal ultrasound, prognosis and chromosome results of fetal bowel dilatation. And in order to further improve the positive rate of prenatal chromosome examination operation, and reduce the risk of missed diagnosis. Methods: Ninety fetuses who were diagnosed as fetal bowel dilatation by prenatal ultrasound from June 2013 to December 2015 in the Second hospital of Jilin University were enrolled. Chromosomes were examined by amniotic cavity puncture or umbilical cord blood puncture...
September 6, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Ayşe Filiz Avşar, Elçin İşlek Seçen, Gülin Feykan Yeğin Akçay, Hüseyin Levent Keskin, Emre Erdem Taş, Ahmet Ferit Dalgacı
OBJECTIVE: To investigate the relationship between the development of intrapartum fetal distress and serum pregnancy-associated plasma protein-A (PAPP-A) levels measured during first-trimester aneuploidy screening tests. MATERIAL AND METHODS: This retrospective study included 283 uncomplicated pregnancies that resulted in full-term live births via spontaneous labor or with the induction by oxytocin. Cases were divided into two groups based on whether their first-trimester PAPP-A multiple of the median (MoM) levels were ≤0...
2016: Journal of the Turkish German Gynecological Association
Manisha Vernekar, Roy Rajib
INTRODUCTION: Uterine rupture is a catastrophic obstetrical emergency associated with a significant feto-maternal morbidity and mortality. Many risk factors for uterine rupture, as well as a wide range of clinical presentations, have been identified. OBJECTIVES: To analyze the frequency, predisposing factors, and maternal and fetal outcomes of uterine rupture. METHODS: A retrospective analysis of cases of unscarred uterine rupture was conducted at the Department of Obstetrics and Gynecology, RIMS, Imphal from June 1, 2010 to June 30, 2012...
October 2016: Journal of Obstetrics and Gynaecology of India
Chanderdeep Sharma, Anjali Soni, Pawan K Soni, Suresh Verma, Ashok Verma, Amit Gupta
OBJECTIVE: To investigate the role of "mifepristone" for induction of labor (IOL) in pregnant women with prior cesarean section (CS). METHODS: In this retrospective study, all pregnant women with prior CS who received oral mifepristone (400 mg) for IOL (as per clear obstetric indications) [group 1] were compared with pregnant women with prior CS who had spontaneous onset of labor (SOL) [group 2], with respect to incidence of vaginal delivery, CS, duration of labor, and various maternal and fetal outcomes...
October 2016: Journal of Obstetrics and Gynaecology of India
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