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https://www.readbyqxmd.com/read/29773941/periodontal-disease-and-diabetes-perceptions-communication-and-referral-between-rural-primary-care-physicians-and-dentists
#1
Paige M Fisketjon, Eric L Johnson
Background and objective: Connections between oral health and systemic disease, specifically diabetes, are well described in the literature. Screening strategies for diabetes in dental settings and dental screenings in diabetes care settings exist. The purpose of this study was to evaluate the communication and referral patterns between dentists and physicians in a rural state with respect to recognition of dental disease and diabetes. Methods: Surveys were sent to the members of the North Dakota Academy of Family Physicians, the North Dakota Medical Association, and the North Dakota Dental Association...
May 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29773933/prevalence-of-and-risk-factors-for-prediabetes-in-patients-infected-with-hiv
#2
Syed Arafath, Tavajay Campbell, Jameela Yusuff, Roopali Sharma
Background: The use of highly active antiretroviral therapy (HAART) has resulted in a dramatic decrease in morbidity and mortality in HIV-infected patients. Components of HAART (e.g., protease inhibitors and nucleoside reverse transcriptase inhibitors), as well as HIV infection itself, can have significant effects on developing new-onset diabetes. The goals of this study were to determine the prevalence of prediabetes and to assess risk factors associated with prediabetes in a cohort of HIV-infected patients...
May 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29767246/dnajc3-mutation-in-thai-familial-type-2-diabetes-mellitus
#3
Sirikul Kulanuwat, Watip Tangjittipokin, Prapaporn Jungtrakoon, Chutima Chanprasert, Jatuporn Sujjitjoon, Ninareeman Binnima, Pa-Thai Yenchitsomanus, Nattachet Plengvidhya
Type 2 diabetes mellitus (T2D) is a heterogeneous disease, with certain cases presenting an autosomal dominant type. The rare coding variants of disease‑causing genes in T2D remain mostly unclear. The present study aimed to identify the disease‑causing gene conducting whole exome sequencing in a Thai T2D family with an autosomal dominant transmission of T2D with no evidence of mutations in known maturity‑onset diabetes of the young (MODY) genes. Candidate variants were selected according to certain criteria of mutation prediction programs, followed by segregation analysis with diabetes in the family...
May 14, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29763602/a-ketogenic-diet-reduces-metabolic-syndrome-induced-allodynia-and-promotes-peripheral-nerve-growth-in-mice
#4
Michael A Cooper, Blaise W Menta, Consuelo Perez-Sanchez, Megan M Jack, Zair W Khan, Janelle M Ryals, Michelle Winter, Douglas E Wright
Current experiments investigated whether a ketogenic diet impacts neuropathy associated with obesity and prediabetes. Mice challenged with a ketogenic diet were compared to mice fed a high-fat diet or a high-fat diet plus exercise. Additionally, an intervention switching to a ketogenic diet following 8 weeks of high-fat diet was performed to compare how a control diet, exercise, or a ketogenic diet affects metabolic syndrome-induced neural complications. When challenged with a ketogenic diet, mice had reduced bodyweight and fat mass compared to high-fat-fed mice, and were similar to exercised, high-fat-fed mice...
May 12, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29762253/glucose-tolerance-is-linked-to-postprandial-fuel-use-independent-of-exercise-dose
#5
Nicole M Gilbertson, Natalie Z M Eichner, Monique Francois, Julian M Gaitán, Emily M Heiston, Arthur Weltman, Steven K Malin
PURPOSE: The optimal short-term exercise dose to improve glucose tolerance in relation to metabolic flexibility and/or insulin resistance is unknown. Therefore, we tested if short-term, work-matched continuous (CONT) versus interval (INT) exercise training improves glucose tolerance in part by reducing insulin resistance and increasing metabolic flexibility independent of clinically meaningful fat loss in adults with prediabetes. METHODS: Subjects (age 60.9±1.4y; BMI 33...
May 14, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29760272/physical-activity-assessment-and-counseling-in-quebec-family-medicine-groups
#6
Aurélie Baillot, Jean-Patrice Baillargeon, Alex Paré, Thomas G Poder, Christine Brown, Marie-France Langlois
OBJECTIVE: To determine how often primary health care providers (PHCPs) in family medicine groups (FMGs) assess physical activity (PA) levels, provide PA counseling (PAC), and refer patients to exercise professionals; to describe patients' PA levels, physical fitness, and satisfaction regarding their PA management in FMGs; to describe available PA materials in FMGs and PHCPs' PAC self-efficacy and PA knowledge; and to identify characteristics of patients and PHCPs that determine the assessment of PA and PAC provided by PHCPs...
May 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29757486/global-status-of-diabetes-prevention-and-prospects-for-action-a-consensus-statement
#7
REVIEW
Mahmoud Ibrahim, Jaakko Tuomilehto, Pablo Aschner, Lucille Beseler, Avivit Cahn, Robert H Eckel, Amy Hess Fischl, George Guthrie, James O Hill, Mick Kumwenda, R David Leslie, Darin E Olson, Paolo Pozzilli, Sandra L Weber, Guillermo E Umpierrez
Primary prevention of Type 2 Diabetes (T2D) should be achievable through the implementation of early and sustainable measures. Such prevention follows from addressing modifiable risk factors that predispose an individual to prediabetes, which then gradually progresses to T2D. Several randomised control studies that have found success in preventing the progression to T2D in high-risk populations1,2 have identified early and intensive intervention based on an individualised prevention model as the key factor for participant benefit...
May 14, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29757070/racial-ethnic-disparities-in-diabetes-diagnosis-and-glycemic-control-among-women-of-reproductive-age
#8
Laura E Britton, Jon M Hussey, Jamie L Crandell, Diane C Berry, Jada L Brooks, Amy G Bryant
BACKGROUND: Types 1 and 2 diabetes mellitus complicate pregnancies and threaten the health of women of reproductive age and their children. Among older adults, diabetes morbidity disproportionately burdens racial/ethnic minorities, but diabetes emergence among younger adults has not been as well characterized. The objective of this study was to describe the distribution of diagnosed diabetes, undiagnosed diabetes, suboptimal preconception glycemic control, and prediabetes among women of reproductive age across racial/ethnic backgrounds...
May 14, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29754952/early-time-restricted-feeding-improves-insulin-sensitivity-blood-pressure-and-oxidative-stress-even-without-weight-loss-in-men-with-prediabetes
#9
Elizabeth F Sutton, Robbie Beyl, Kate S Early, William T Cefalu, Eric Ravussin, Courtney M Peterson
Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether these effects are due solely to weight loss. We conducted the first supervised controlled feeding trial to test whether IF has benefits independent of weight loss by feeding participants enough food to maintain their weight. Our proof-of-concept study also constitutes the first trial of early time-restricted feeding (eTRF), a form of IF that involves eating early in the day to be in alignment with circadian rhythms in metabolism...
May 8, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29752665/microcirculatory-improvement-induced-by-laparoscopic-sleeve-gastrectomy-is-related-to-insulin-sensitivity-retrieval
#10
Stefano Ministrini, Chiara Fattori, Maria Anastasia Ricci, Vanessa Bianconi, Rita Paltriccia, Marcello Boni, Maria Teresa Paganelli, Gaetano Vaudo, Graziana Lupattelli, Leonella Pasqualini
AIMS: Microvascular dysfunction is a potential factor explaining the association of obesity, insulin resistance, and vascular damage in morbidly obese subjects. The purpose of the study was to evaluate possible determinants of microcirculatory improvement 1 year after laparoscopic sleeve gastrectomy (LSG) intervention. METHODS: Thirty-seven morbidly obese subjects eligible for bariatric surgery were included in the study. Post-occlusive reactive hyperemia (PORH) of the forearm skin was measured as area of hyperemia (AH) by laser-Doppler flowmetry before LSG and after a 1-year follow-up...
May 12, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29752393/cardiac-structural-remodeling-longitudinal-systolic-strain-and-torsional-mechanics-in-lean-and-nonlean-dysglycemic-chinese-adults
#11
Jiun-Lu Lin, Kuo-Tzu Sung, Cheng-Huang Su, Tzu-Hsun Chou, Chi-In Lo, Jui-Peng Tsai, Shun-Chuan Chang, Yau-Huei Lai, Kuang-Chun Hu, Chia-Yuan Liu, Chun-Ho Yun, Chung-Lieh Hung, Hung-I Yeh, Carolyn S P Lam
BACKGROUND: Diabetes mellitus and pre-diabetes mellitus are associated with lower body mass indices and increased risk of cardiovascular events (including heart failure) at lower glucose thresholds in Chinese compared with Western cohorts. However, the extent of cardiac remodeling and regulation on cardiac mechanics in lean and nonlean dysglycemic Chinese adults is understudied. METHODS AND RESULTS: We studied 3950 asymptomatic Chinese (aged 49.7±10.7 years; 65% male; body mass index: 24...
May 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29750244/regulation-of-hepatic-lipid-accumulation-and-distribution-by-agouti-related-protein-in-male-mice
#12
Matthew T Maier, Anna Vilhelmsson, Sharon M Louie, Eirini Vagena, Daniel K Nomura, Suneil K Koliwad, Allison W Xu
Proper regulation of energy metabolism requires CNS neurons to respond dynamically to signals that reflect the body's energy reserve, and one such signal is leptin. Agouti-related protein (AgRP) is a hypothalamic neuropeptide that is markedly upregulated in leptin deficiency, a condition that is associated with severe obesity, diabetes and hepatic steatosis. Since deleting AgRP in mice does not alter energy balance, we sought to determine whether AgRP plays an indispensable role in regulating energy and hepatic lipid metabolism in the sensitized background of leptin deficiency...
May 9, 2018: Endocrinology
https://www.readbyqxmd.com/read/29749131/the-impact-of-prediabetes-on-two-year-clinical-outcomes-in-patients-undergoing-elective-percutaneous-coronary-intervention
#13
Woong Gil Choi, Seung Woon Rha, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Ahmed Mashaly, Yoonjee Park, Won Young Jang, Woohyeun Kim, Jah Yeon Choi, Eun Jin Park, Jin Oh Na, Cheol Ung Choi, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo
PURPOSE: Prediabetes is an independent risk factor for cardiovascular disease. However, data on the long term adverse clinical outcomes of prediabetic patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) are scarce. MATERIALS AND METHODS: The study population comprised 674 consecutive non-diabetic patients who underwent elective PCI between April 2007 and November 2010. Prediabetes was defined as hemoglobin A1c (HbA1c) of 5...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29746878/effect-of-short-bouts-of-high-intensity-activity-on-glucose-among-adults-with-prediabetes-a-pilot-randomized-crossover-study
#14
Jennifer L Gay, David M Buchner, Melissa L Erickson, Adolphia Lauture
AIM: Few data exist on the effects of vigorous-intensity activity on blood glucose. The study aim was to determine the effects of 2-min and 4-min bouts of vigorous-intensity stair climbing on glucose levels. METHODS: Nine overweight/obese adults with prediabetes (40-64 years, HbA1C 5.7%-6.4%) participated in a randomized cross-over design with three conditions on consecutive days: control; 2-min bouts of stair climbing once per hour for 8 hours; and 4-min bouts of stair climbing once every 2 hours for 8 hours, with the two activity days randomized in order...
May 7, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29746188/special-considerations-in-the-management-of-diabetes-in-women
#15
Diana B McNeill, Rebecca Herbst
INTRODUCTION: Type 2 diabetes and prediabetes are heterogeneous diseases that directly affect over 115 million Americans. Considerable gender differences exist with regard to diabetes risk factors, hormonal effects on glucose, and cardiovascular outcomes. MATERIALS AND METHODS: Historically, diabetes studies have largely focused on men with the assumption that the data can safely be extrapolated to women. However, more recent investigations have illuminated significant differences between genders...
May 10, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29743959/vitamin-d-and-incidence-of-prediabetes-or-type-2-diabetes-a-four-year-follow-up-community-based-study
#16
Yun Gao, Tianpeng Zheng, Xingwu Ran, Yan Ren, Tao Chen, Li Zhong, Donge Yan, Fangfang Yan, Qianlin Wu, Haoming Tian
Aim: To examine whether the baseline 25-hydroxyvitamin D [25(OH)D] level was predictive of the onset of prediabetes or type 2 diabetes (T2DM) in the Chinese population. Methods: This was a 4-year follow-up study that was conducted in the Chengdu region of China as part of the China National Diabetes and Metabolic Disorders Study. The study included 490 participants that were free of prediabetes and type 2 diabetes mellitus (T2DM) at baseline and had complete data by follow-up examinations...
2018: Disease Markers
https://www.readbyqxmd.com/read/29743813/plasma-asprosin-concentrations-are-increased-in-individuals-with-glucose-dysregulation-and-correlated-with-insulin-resistance-and-first-phase-insulin-secretion
#17
Yuren Wang, Hua Qu, Xin Xiong, Yuyang Qiu, Yong Liao, Yingchun Chen, Yi Zheng, Hongting Zheng
Background: Adipokines are reported to participate in many common pathologic processes of glucose dysregulation, such as insulin resistance, β -cell dysfunction, and chronic inflammation. Objective: To detect the concentrations of plasma asprosin in subjects with impaired glucose regulation (IGR) and newly diagnosed type 2 diabetes (nT2DM) and its relationship to parameters of glucose and lipid metabolism, insulin resistance, and pancreatic β -cell function. Methods: 143 eligible participants were included and were divided into three groups including normal glucose regulation (NGR, n = 52), IGR ( n = 40), and nT2DM group ( n = 51)...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29743321/identical-anthropometric-characteristics-of-impaired-fasting-glucose-combined-with-impaired-glucose-tolerance-and-newly-diagnosed-type-2-diabetes-anthropometric-indicators-to-predict-hyperglycaemia-in-a-community-based-prospective-cohort-study-in-southwest
#18
Fang Zhang, Qin Wan, Hongyi Cao, Lizhi Tang, Daigang Li, Qingguo Lü, Zhe Yan, Jing Li, Qiu Yang, Yuwei Zhang, Nanwei Tong
OBJECTIVES: To assess the anthropometric characteristics of normoglycaemic individuals who subsequently developed hyperglycaemia, and to evaluate the validity of these measures to predict prediabetes and diabetes. DESIGN: A community-based prospective cohort study. PARTICIPANTS: In total, 1885 residents with euglycaemia at baseline from six communities were enrolled. SETTING: Sichuan, southwest China. PRIMARY OUTCOME MEASURES: The incidences of prediabetes and diabetes were the primary outcomes...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29743168/gestational-diabetes-with-diabetes-and-prediabetes-risks-a-large-observational-study
#19
Yun Shen, Peng Wang, Leishen Wang, Shuang Zhang, Huikun Liu, Weiqin Li, Nan Li, Wei Li, Junhong Leng, Jing Wang, Huiguang Tian, Cuilin Zhang, Jaakko Tuomilehto, Xilin Yang, Zhijie Yu, Gang Hu
Aims To compare risks of early postpartum diabetes and prediabetes in Chinese women with and without gestational diabetes mellitus (GDM) during pregnancy Subjects and methods Tianjin GDM observational study included 1263 women with a history of GDM and 705 women without GDM who participated in the urban GDM universal screening survey by using World Health Organization's criteria. Postpartum diabetes and prediabetes were identified after a standard oral glucose tolerance test. Cox proportional hazards regression was used to assess risks of postpartum diabetes and prediabetes between women with and without GDM...
May 9, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29741558/effect-of-a-high-egg-diet-on-cardiometabolic-risk-factors-in-people-with-type-2-diabetes-the-diabetes-and-egg-diabegg-study-randomized-weight-loss-and-follow-up-phase
#20
Nicholas R Fuller, Amanda Sainsbury, Ian D Caterson, Gareth Denyer, Mackenzie Fong, James Gerofi, Chloris Leung, Namson S Lau, Kathryn H Williams, Andrzej S Januszewski, Alicia J Jenkins, Tania P Markovic
Background: Some country guidelines recommend that people with type 2 diabetes (T2D) limit their consumption of eggs and cholesterol. Our previously published 3-mo weight-maintenance study showed that a high-egg (≥12 eggs/wk) diet compared with a low-egg diet (<2 eggs/wk) did not have adverse effects on cardiometabolic risk factors in adults with T2D. Objective: The current study follows the previously published 3-mo weight-maintenance study and assessed the effects of the high-egg compared with the low-egg diets as part of a 3-mo weight-loss period, followed by a 6-mo follow-up period for a total duration of 12 mo...
May 7, 2018: American Journal of Clinical Nutrition
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