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Prediabetes

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https://www.readbyqxmd.com/read/28319805/depressive-states-among-adults-with-diabetes-findings-from-the-national-health-and-nutrition-examination-survey-2007-2012
#1
Juan Rafael Albertorio-Diaz, Mark S Eberhardt, Maria Oquendo, Marco Mesa-Frias, Yulei He, Bruce Jonas, Kai Kang
AIMS: To determine (1) the prevalence of SubD states among adults with diabetes, and (2) whether evidence exists of an independent association between diabetes status and SubD, controlling for selected confounders. METHODS: Data from the 2007-2012 National Health and Nutrition Examination Surveys were combined to estimates of depressive states by diabetes status among the noninstitutionalized U.S. adult population, and to assess the association of diabetes status and depressive states using a polytomous logistic regression model...
February 27, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28302101/preventing-diabetes-in-obese-latino-youth-with-prediabetes-a-study-protocol-for-a-randomized-controlled-trial
#2
Erica G Soltero, Yolanda P Konopken, Micah L Olson, Colleen S Keller, Felipe G Castro, Allison N Williams, Donald L Patrick, Stephanie Ayers, Houchun H Hu, Matthew Sandoval, Janiel Pimentel, William C Knowler, Kevin D Frick, Gabriel Q Shaibi
BACKGROUND: Obese Latino adolescents are disproportionately impacted by insulin resistance and type 2 diabetes. Prediabetes is an intermediate stage in the pathogenesis of type 2 diabetes and represents a critical opportunity for intervention. However, to date, no diabetes prevention studies have been conducted in obese Latino youth with prediabetes, a highly vulnerable and underserved group. Therefore, we propose a randomized-controlled trial to test the short-term (6-month) and long-term (12-month) efficacy of a culturally-grounded, lifestyle intervention, as compared to usual care, for improving glucose tolerance and reducing diabetes risk in 120 obese Latino adolescents with prediabetes...
March 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28298255/using-mutpred-derived-mtdna-load-scores-to-evaluate-mtdna-variation-in-hypertension-and-diabetes-in-a-two-population-cohort-the-sabpa-study
#3
Marianne Venter, Leone Malan, Etresia van Dyk, Joanna L Elson, Francois H van der Westhuizen
Mitochondrial DNA (mtDNA) variation has been implicated in many common complex diseases, but inconsistent and contradicting results are common. Here we introduce a novel mutational load hypothesis, which also considers the collective effect of mainly rare variants, utilising the MutPred Program. We apply this new methodology to investigate the possible role of mtDNA in two cardiovascular disease (CVD) phenotypes (hypertension and hyperglycaemia), within a two-population cohort (n = 363; mean age 45 ± 9 yrs)...
December 26, 2016: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28295686/increased-insulin-stimulated-glucose-uptake-in-both-leg-and-arm-muscles-after-sprint-interval-and-moderate-intensity-training-in-subjects-with-type-2-diabetes-or-prediabetes
#4
Tanja J Sjöros, Marja A Heiskanen, Kumail K Motiani, Eliisa Löyttyniemi, Jari-Joonas Eskelinen, Kirsi A Virtanen, Nina J Savisto, Olof Solin, Jarna C Hannukainen, Kari K Kalliokoski
We investigated the effects of sprint interval (SIT) and moderate intensity continuous training (MICT) on glucose uptake (GU) during hyperinsulinemic euglycemic clamp and fatty acid uptake (FAU) at fasting state in thigh and arm muscles in subjects with type 2 diabetes (T2D) or prediabetes. Twenty-six patients (age 49, SD 4; 10 women) were randomly assigned into two groups: SIT (n=13), and MICT (n=13). The exercise in the SIT group consisted of 4-6 x 30 s of all-out cycling with 4 min recovery and in the MICT group 40-60 min cycling at 60% of VO2peak ...
March 13, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28293642/erratum-to-expression-profiling-of-genes-related-to-endothelial-cells-biology-in-patients-with-type-2-diabetes-and-patients-with-prediabetes
#5
Sara Moradipoor, Patimah Ismail, Ali Etemad, Wan Aliaa Wan Sulaiman, Salma Ahmadloo, Somayeh Khazaei
[This corrects the article DOI: 10.1155/2016/1845638.].
2017: BioMed Research International
https://www.readbyqxmd.com/read/28293638/metabolic-disorders-in-hiv-infected-adolescents-receiving-protease-inhibitors
#6
Jeerunda Santiprabhob, Surapong Tanchaweng, Sirinoot Maturapat, Alan Maleesatharn, Watcharee Lermankul, Sirintip Sricharoenchai, Orasri Wittawatmongkol, Keswadee Lapphra, Wanatpreeya Phongsamart, Kulkanya Chokephaibulkit
Protease inhibitor (PI) may cause abnormal glucose metabolism, abnormal lipid metabolism, and metabolic syndrome in HIV-infected adults but less well studied in Asian adolescents. This cross-sectional study evaluated anthropometric factors, oral glucose tolerance test, and lipid profiles of perinatally HIV-infected Thai adolescents who had received PI-based antiretroviral therapy for at least 6 months. Eighty adolescents were enrolled [median (IQR) age 16.7 (14.6-18.0) years, 42 males]. Metabolic syndrome, prediabetes, and type 2 diabetes mellitus (T2DM) were found in 8 (10%), 17 (22...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28289117/systematic-diabetes-screening-using-point-of-care-hba1c-testing-facilitates-identification-of-prediabetes
#7
Heather P Whitley, Courtney Hanson, Jason M Parton
This prospective longitudinal study compares diabetes screenings between standard practices vs systematically offered point-of-care (POC) hemoglobin A1c (HbA1c) tests in patients aged 45 years or older. Systematically screened participants (n = 164) identified 63% (n = 104) with unknown hyperglycemia and 53% (n = 88) in prediabetes. The standard practice (n = 324) screened 22% (n = 73), most commonly by blood glucose (96%); 8% (n = 6) and 33% (n = 24) were found to have diabetes and prediabetes, respectively...
March 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28289069/omega-3-polyunsaturated-fatty-acid-fish-oil-supplementation-and-the-prevention-of-clinical-cardiovascular-disease-a-science-advisory-from-the-american-heart-association
#8
REVIEW
David S Siscovick, Thomas A Barringer, Amanda M Fretts, Jason H Y Wu, Alice H Lichtenstein, Rebecca B Costello, Penny M Kris-Etherton, Terry A Jacobson, Mary B Engler, Heather M Alger, Lawrence J Appel, Dariush Mozaffarian
Multiple randomized controlled trials (RCTs) have assessed the effects of supplementation with eicosapentaenoic acid plus docosahexaenoic acid (omega-3 polyunsaturated fatty acids, commonly called fish oils) on the occurrence of clinical cardiovascular diseases. Although the effects of supplementation for the primary prevention of clinical cardiovascular events in the general population have not been examined, RCTs have assessed the role of supplementation in secondary prevention among patients with diabetes mellitus and prediabetes, patients at high risk of cardiovascular disease, and those with prevalent coronary heart disease...
March 13, 2017: Circulation
https://www.readbyqxmd.com/read/28286536/associations-among-osteocalcin-leptin-and-metabolic-health-in-children-ages-9-13-years-in-the-united-states
#9
Kelly Virecoulon Giudici, Joseph M Kindler, Berdine R Martin, Emma M Laing, George P McCabe, Linda D McCabe, Dorothy B Hausman, Lígia Araújo Martini, Richard D Lewis, Connie M Weaver, Munro Peacock, Kathleen M Hill Gallant
BACKGROUND: This study aimed to investigate the relationships among osteocalcin, leptin and metabolic health outcomes in children ages 9-13 years. METHODS: This was a cross-sectional analysis of baseline data from 161 boys and 157 girls (ages 9-13 years) who previously participated in a double-blinded randomized placebo controlled trial of vitamin D supplementation. Relationships among fasting serum total osteocalcin (tOC), undercarboxylated osteocalcin (ucOC), leptin, and metabolic health outcomes were analyzed...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28279547/performance-of-a-random-glucose-case-finding-strategy-to-detect-undiagnosed-diabetes
#10
Michael E Bowen, Lei Xuan, Ildiko Lingvay, Ethan A Halm
INTRODUCTION: Random glucose <200 mg/dL is associated with undiagnosed diabetes but not included in screening guidelines. This study describes a case-finding approach using non-diagnostic random glucose values to identify individuals in need of diabetes testing and compares its performance to current screening guidelines. METHODS: In 2015, cross-sectional data from non-fasting adults without diagnosed diabetes or prediabetes (N=7,161) in the 2007-2012 National Health and Nutrition Examination Surveys were analyzed...
February 24, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28278130/cardiometabolic-risk-factors-among-1-3-million-adults-with-overweight-or-obesity-but-not-diabetes-in-10-geographically-diverse-regions-of-the-united-states-2012-2013
#11
Gregory A Nichols, Michael Horberg, Corinna Koebnick, Deborah Rohm Young, Beth Waitzfelder, Nancy E Sherwood, Matthew F Daley, Assiamira Ferrara
INTRODUCTION: Various phenotypes of overweight and obesity pose various health risks. The objective of this study was to determine the prevalence of 4 commonly measured cardiometabolic risk factors (CRFs) among adults with overweight or obesity, but not diabetes, at the time of the study. METHODS: We analyzed data for 1,294,174 adults (aged ≥20 y) who were members of one of 4 integrated health systems. Each cohort member had a body mass index in 2012 or 2013 that indicated overweight or obesity...
March 9, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28277390/empowerment-program-for-people-with-prediabetes-a-randomized-controlled-trial
#12
Mei-Fang Chen, Shu-Ling Hung, Shu-Lin Chen
BACKGROUND: Practicing a health-promoting lifestyle is believed to be effective for delaying or preventing the onset of diabetes. However, although empowerment interventions have proven effective for encouraging the adoption of a health-promoting lifestyle in people with diabetes, these interventions are rarely promoted to people with prediabetes. PURPOSE: The aims of this study were to develop an empowerment program for people with prediabetes and to examine its efficacy in terms of the adoption of a health-promoting lifestyle and improvements in blood sugar, body mass index, and self-efficacy...
April 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28267267/peripheral-neuropathy-in-prediabetes-and-the-metabolic-syndrome
#13
REVIEW
Amro M Stino, A Gordon Smith
Peripheral neuropathy is a major cause of disability worldwide. Diabetes is the most common cause of neuropathy, accounting for 50% of cases. Over half of people with diabetes develop neuropathy, and diabetic neuropathy (DPN) is a major cause of reduced quality of life due to pain, sensory loss, gait instability, fall related injury, and foot ulceration and amputation. Most patients with nondiabetic neuropathy have cryptogenic sensory peripheral neuropathy (CSPN). A growing body of literature links prediabetes, obesity and metabolic syndrome (MetS) to risk of both DPN and CSPN (CSPN-MetS)...
March 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28264942/impact-of-the-ymca-of-the-usa-diabetes-prevention-program-on-medicare-spending-and-utilization
#14
Maria L Alva, Thomas J Hoerger, Ravikumar Jeyaraman, Peter Amico, Lucia Rojas-Smith
The YMCA of the USA received a Health Care Innovation Award from the Centers for Medicare and Medicaid Services to provide a diabetes prevention program to Medicare beneficiaries with prediabetes in seventeen regional networks of participating YMCAs nationwide. The goal of the program is to help participants lose weight and increase physical activity. We tested whether the program reduced medical spending and utilization in the Medicare population. Using claims data to compute total medical costs for fee-for-service Medicare participants and a matched comparison group of nonparticipants, we found that the overall weighted average savings per member per quarter during the first three years of the intervention period was $278...
March 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28260449/living-kidney-donor-cancellation-at-king-hussein-medical-center
#15
Katibh Al-Rabadi, Reham Issa Almardini, Mysoon Hajeer, Mahmood Hendawi, Aiham Hadad
OBJECTIVES: Living-related kidney donation is the main source of renal grafts in Jordan, since kidneys from deceased donors are scarce. Although the Jordanian community accepts the idea of kidney donation to family members, not all potential donors manage to complete the required psychologic and medical evaluations. We review the causes of kidney-donation cancellation and suggest options to increase the number of available organs. MATERIALS AND METHODS: We performed a retrospective chart review of all potential living-related kidney donors at King Hussein Medical Center between January 2008 and June 2016...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28259644/association-of-serum-25-hydroxyvitamin-d3-with-adipokines-and-inflammatory-marker-in-persons-with-prediabetes-mellitus
#16
Meilin Zhang, Yuxia Gao, Liqiang Tian, Li Zheng, Xuan Wang, Weiqiao Liu, Yuwen Zhang, Guowei Huang
BACKGROUND: The association of vitamin D status and inflammation prediabetes mellitus (PreDM) individuals has not been investigated. We investigated the association of serum 25-hydroxyvitamin D3 (25(OH) D3) with adipokines and inflammatory markers in persons with PreDM. METHODS: In this cross-sectional study, we stratified 418 nondiabetic subjects as having PreDM or normal fasting glucose (NFG), and divided PreDM or NFG subjects into vitamin D sufficient, vitamin D insufficient and vitamin D deficient subgroups...
March 1, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28258467/diabetes-in-immigrant-tibetan-muslims-in-kashmir-north-india
#17
Mirza Shohiab Ur Riyaz, Majid Khalil Rather, Parvaiz A Koul
Tibetan Muslims have migrated from Lhasa (3000 m altitude) to Srinagar, India (altitude 1500 m) about 55 years back. We set out to study the prevalence of diabetes and prediabetes among this immigrant population. All consenting adults aged ≥18 years were questioned about a previous history of diabetes or any other medical history. Anthropometric data were recorded. Fasting blood glucose was measured in duplicate by Accu-check glucometer and HbA1C levels were measured. Of the 281 participants, 26 (9.25%) had diabetes whereas 46 (16...
March 3, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28258257/increased-vascular-disease-mortality-risk-in-prediabetic-korean-adults-is-mainly-attributable-to-ischemic-stroke
#18
Nam Hoon Kim, Tae Yeon Kwon, Sungwook Yu, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yousung Park, Sin Gon Kim
BACKGROUND AND PURPOSE: Prediabetes is a known risk factor for vascular diseases; however, its differential contribution to mortality risk from various vascular disease subtypes is not known. METHODS: The subjects of the National Health Insurance Service in Korea (2002-2013) nationwide cohort were stratified into normal glucose tolerance (fasting glucose <100 mg/dL), impaired fasting glucose (IFG) stage 1 (100-109 mg/dL), IFG stage 2 (110-125 mg/dL), and diabetes mellitus groups based on the fasting glucose level...
March 3, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28255300/serum-osteoprotegerin-is-a-potential-biomarker-of-insulin-resistance-in-chinese-postmenopausal-women-with-prediabetes-and-type-2-diabetes
#19
Peng Duan, Min Yang, Meilin Wei, Jia Liu, Ping Tu
The aim of this study is to investigate the circulating OPG levels in postmenopausal women with diabetes and prediabetes and explore the relationships between serum OPG and insulin resistance. A total of 271 unrelated Chinese postmenopausal women were recruited in this study. The subjects were divided into type 2 diabetes mellitus (T2DM) group (n = 93), impaired glucose regulation (IGR) (n = 90), and normal glucose regulation group (NGR) (n = 88), according to different glucose regulation categories. Serum OPG levels were measured by enzyme-linked immunosorbent assay...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28248753/update-on-the-risks-of-benign-adrenocortical-incidentalomas
#20
Guido Di Dalmazi
PURPOSE OF REVIEW: Recent studies highlighted the association between adrenocortical incidentalomas and several comorbidities. This review summarizes the most recent evidence showing the potential risks related to adrenocortical tumors classified as nonfunctioning adrenal incidentalomas (NFAIs) or associated with clinically autonomous cortisol secretion (ACS). RECENT FINDINGS: Alterations in glucose metabolism are a common finding in patients with ACS (30% of the cases)...
February 28, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
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