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https://www.readbyqxmd.com/read/28092345/acute-effects-of-a-beverage-containing-bitter-melon-extract-carela-on-postprandial-glycemia-among-prediabetic-adults
#1
C H Boone, J R Stout, J A Gordon, M J Redd, D D Church, L P Oliveira, D H Fukuda, J R Hoffman
BACKGROUND: Acute ingestion of bitter melon (BM) has been shown to suppress the postprandial glycemic response in diabetics, but its impact on glucose regulation among individuals with impaired glucose tolerance is unclear. Moreover, one's glucose tolerance level may influence the effectiveness of BM. This study aimed to examine the acute effects of a beverage containing BM extract on blood glucose regulation during an oral glucose tolerance test (OGTT) among prediabetics. METHODS: Ten prediabetic adults completed two OGTTs-glucose only (D2) and glucose+BM (D3)...
January 16, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28091589/platelet-monocyte-and-neutrophil-activation-and-glucose-tolerance-in-south-african-mixed-ancestry-individuals
#2
Glenda M Davison, Bongani B Nkambule, Zibusiso Mkandla, Gloudina M Hon, Andre P Kengne, Rajiv T Erasmus, Tandi E Matsha
Platelet activation has been described in patients with chronic inflammation, however in type 2 diabetes mellitus it remains controversial. We compared levels of platelet leucocyte aggregates, monocyte and granulocyte activation across glucose tolerance statuses in mixed ancestry South Africans. Individuals (206) were recruited from Bellville-South, Cape Town, and included 66% with normal glucose tolerance, 18.7% pre-diabetes, 8.7% screen-detected diabetes and 6.3% known diabetes. Monocyte and neutrophil activation were measured by calculating the percentage of cells expressing CD142 and CD69 while platelet monocyte aggregates were defined as CD14(++) CD42b(+) events and platelet neutrophil aggregates as CD16(++) CD42b(+) events...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28091558/soluble-urokinase-receptor-supar-predicts-microalbuminuria-in-patients-at-risk-for-type-2-diabetes-mellitus
#3
Martina Guthoff, Robert Wagner, Elko Randrianarisoa, Erifili Hatziagelaki, Andreas Peter, Hans-Ulrich Häring, Andreas Fritsche, Nils Heyne
Early identification of patients at risk of developing diabetic nephropathy is essential. Elevated serum concentrations of soluble urokinase receptor (suPAR) associate with diabetes mellitus and predict onset and loss of renal function in chronic kidney disease. We hypothesize, that suPAR may be an early risk indicator for diabetic nephropathy, preceding microalbuminuria. The relationship of baseline suPAR and incident microalbuminuria was assessed in a prospective long-term cohort of subjects at increased risk for type 2 diabetes (TULIP, n = 258)...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28081577/can-hba1c-be-used-to-screen-for-glucose-abnormalities-among-adults-with-severe-mental-illness
#4
A J Romain, E Letendre, Z Akrass, A Avignon, A D Karelis, A Sultan, A Abdel-Baki
Aim: Prediabetes and type 2 diabetes are highly prevalent among individuals with serious mental illness and increased by antipsychotic medication. Although widely recommended, many obstacles prevent these patients from obtaining a proper screening for dysglycemia. Currently, glycated hemoglobin (HbA1c), fasting glucose, and 2-hour glucose levels from the oral glucose tolerance test are used for screening prediabetes and type 2 diabetes. The objective of this study was to investigate if HbA1c could be used as the only screening test among individuals with serious mental illness...
January 12, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28078386/early-differences-in-islets-from-prediabetic-nod-mice-combined-microarray-and-proteomic-analysis
#5
Inne Crèvecoeur, Valborg Gudmundsdottir, Saurabh Vig, Fernanda Marques Câmara Sodré, Wannes D'Hertog, Ana Carolina Fierro, Leentje Van Lommel, Conny Gysemans, Kathleen Marchal, Etienne Waelkens, Frans Schuit, Søren Brunak, Lut Overbergh, Chantal Mathieu
AIMS/HYPOTHESIS: Type 1 diabetes is an endocrine disease where a long preclinical phase, characterised by immune cell infiltration in the islets of Langerhans, precedes elevated blood glucose levels and disease onset. Although several studies have investigated the role of the immune system in this process of insulitis, the importance of the beta cells themselves in the initiation of type 1 diabetes is less well understood. The aim of this study was to investigate intrinsic differences present in the islets from diabetes-prone NOD mice before the onset of insulitis...
January 12, 2017: Diabetologia
https://www.readbyqxmd.com/read/28076259/almond-appetizer-effect-on-glucose-tolerance-test-gtt-results
#6
Michael A Crouch, Robert T Slater
BACKGROUND: The extent to which glucose intolerance can be acutely improved with dietary modification is unclear. The purpose of this study was to test the effect of ingesting a low-calorie almond preload ("appetizer") 30 minutes before oral glucose tolerance testing in glucose-intolerant individuals without diabetes. METHODS: Twenty adults with prediabetes or isolated 1-hour glucose ≥160 mg/dL underwent 2 fasting oral glucose tolerance tests (GTTs)-1 standard GTT and 1 GTT 30 minutes after eating a half ounce (12) of dry-roasted almonds...
November 2016: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28076248/prediabetes-screening-and-treatment-in-diabetes-prevention-the-impact-of-physician-attitudes
#7
Arch G Mainous, Rebecca J Tanner, Christopher B Scuderi, Maribeth Porter, Peter J Carek
PURPOSE: Detection and treatment of prediabetes is an effective strategy in diabetes prevention. However, most patients with prediabetes are not identified. Our objective was to evaluate the relationship between attitudes toward prediabetes as a clinical construct and screening/treatment behaviors for diabetes prevention among US family physicians. METHODS: An electronic survey of a national sample of academic family physicians (n 1248) was conducted in 2016. Attitude toward prediabetes was calculated using a summated scale assessing agreement with statements regarding prediabetes as a clinical construct...
November 2016: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28073130/testosterone-plasma-concentration-is-associated-with-insulin-resistance-in-male-hypertensive-patients
#8
Gian Piero Carnevale Schianca, Gian Paolo Fra, Fabio Brustia, Mattia Bellan, Alice Pirovano, Alessandro Gualerzi, Michela Gentile, Antonello Gibbin, Mirta Menegatti, Ettore Bartoli, Mario Pirisi
Background: Low testosterone levels are a common finding among men with Type 2 Diabetes Mellitus (T2DM) and are inversely related to insulin resistance. Whether this relationship holds true in patients with hypertension, but normal glucose tolerance or prediabetes, is unclear. Methods: We recruited 87 male outpatients with essential arterial hypertension, aged 35-70 years. Anthropometric data were collected, an Oral Glucose Tolerance Test (OGTT) performed, and the homeostasis model assessment of insulin resistance (HOMA-IR) score calculated...
January 10, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28070750/examining-trends-in-prediabetes-and-its-relationship-with-the-metabolic-syndrome-in-us-adolescents-1999-2014
#9
Arthur M Lee, Cyrelle R Fermin, Stephanie L Filipp, Matthew J Gurka, Mark D DeBoer
AIMS: We sought to investigate temporal trends in prediabetes prevalence among US adolescents using two definitions and evaluate relationships with obesity and a MetS-severity score. METHODS: We evaluated data from 5418 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12-19 participating in the National Health and Nutrition Examination Survey 1999-2014 with complete data regarding MetS and hemoglobin A1c (HbA1c). Prediabetes status was defined by American Diabetes Association (ADA) criteria: fasting glucose 100-125 mg/dL or HbA1c 5...
January 9, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28069625/cost-effectiveness-of-a-pragmatic-structured-education-intervention-for-the-prevention-of-type-2-diabetes-economic-evaluation-of-data-from-the-let-s-prevent-diabetes-cluster-randomised-controlled-trial
#10
J Leal, D Ahrabian, M J Davies, L J Gray, K Khunti, T Yates, A M Gray
OBJECTIVES: Prevention of type 2 diabetes mellitus (TD2M) is a priority for healthcare systems. We estimated the cost-effectiveness compared with standard care of a structured education programme (Let's Prevent) targeting lifestyle and behaviour change to prevent progression to T2DM in people with prediabetes. DESIGN: Cost-effectiveness analysis alongside randomised controlled trial. SETTING: 44 general practices in Leicestershire, England...
January 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28069054/the-effect-of-a-novel-probiotic-on-metabolic-biomarkers-in-adults-with-prediabetes-and-recently-diagnosed-type-2-diabetes-mellitus-study-protocol-for-a-randomized-controlled-trial
#11
Talia Palacios, Luis Vitetta, Samantha Coulson, Claire D Madigan, Gareth S Denyer, Ian D Caterson
BACKGROUND: Shifts in the gastrointestinal microbiome have been shown to contribute to the progression of metabolic diseases including prediabetes and type 2 diabetes mellitus. Research suggests that in-vivo modulation of the gut microbiome by specific probiotic microorganisms may improve insulin sensitivity and blood sugar management, preventing or delaying the development of type 2 diabetes mellitus. However, further research is needed to understand the effect of probiotics as a therapy for the treatment of metabolic diseases...
January 9, 2017: Trials
https://www.readbyqxmd.com/read/28061844/cardiovascular-disease-risk-factors-in-a-nigerian-population-with-impaired-fasting-blood-glucose-level-and-diabetes-mellitus
#12
Victor M Oguoma, Ezekiel U Nwose, Ifeoma I Ulasi, Adeseye A Akintunde, Ekene E Chukwukelu, Phillip T Bwititi, Ross S Richards, Timothy C Skinner
BACKGROUND: Diabetes is a risk factor for cardiovascular diseases (CVDs) and there are reports of increasing prevalence of prediabetes in Nigeria. This study therefore characterised CVDs risk factors in subjects with impaired fasting glucose (IFG) and diabetes. METHODS: Data from 4 population-based cross-sectional studies on 2447 apparently healthy individuals from 18 - 89 years were analysed. Anthropometric, blood pressure and biochemical parameters were collected and classified...
January 6, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28060789/the-long-term-prospective-follow-up-of-pancreatic-function-after-the-first-episode-of-acute-alcoholic-pancreatitis-recurrence-predisposes-one-to-pancreatic-dysfunction-and-pancreatogenic-diabetes
#13
Jussi Nikkola, Johanna Laukkarinen, Jorma Lahtela, Hanna Seppänen, Satu Järvinen, Isto Nordback, Juhani Sand
BACKGROUND: Data on the prevalence of pancreatic dysfunction after an episode of acute pancreatitis are conflicting. Our aim was to evaluate the natural course of endocrine and exocrine pancreatic function in the long-term follow-up after the first episode of acute alcoholic pancreatitis (AAP). METHODS: A total of 77 patients who survived their first episode of AAP between January 2001 and February 2005 were prospectively followed up for a maximum of 13 years. During the follow-up, patients were repeatedly interviewed and monitored for recurrences, new diabetes, and chronic pancreatitis...
February 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28058711/hyperglycemia-is-associated-with-poor-survival-in-primary-central-nervous-system-lymphoma-patients
#14
Ayumi Debata, Koichi Yoshida, Kenta Ujifuku, Haruna Yasui, Kensaku Kamada, Daisuke Niino, Takayuki Matsuo
PURPOSE: Primary central nervous system lymphoma (PCNSL) is a type of non-Hodgkin lymphoma (NHL), and it has been postulated that metabolic disorder may contribute to NHL etiology. We retrospectively investigated the prognostic significance of hyperglycemia in patients with PCNSL. We evaluated glucose transporter type 1 (GLUT1) expression by immunohistochemistry and analyzed its association with hyperglycemia and survival. METHODS: The medical and neuroradiologic records of 50 patients with PCNSL at our institution over the past 15 years were analyzed...
December 29, 2016: Tumori
https://www.readbyqxmd.com/read/28056420/synergistic-effects-of-acarbose-and-an-oroxylum-indicum-seed-extract-in-streptozotocin-and-high-fat-diet-induced-prediabetic-mice
#15
Wenlong Sun, Yuanbin Sang, Bowei Zhang, Xiaoxia Yu, Qinmin Xu, Zhilong Xiu, Yuesheng Dong
Prediabetes is defined as blood glucose levels above normal but below diabetes thresholds, and up to 70% of individuals with prediabetes will eventually develop diabetes if left untreated. Acarbose, the first FDA approved anti-prediabetes agent, has some disadvantages, such as reducing the risk of diabetes by only 36%, side effects and limited effects on complications. The aim of this study is to develop a new agent to treat prediabetes and to investigate the anti-prediabetes effects and mechanisms of acarbose and an Oroxylum indicum seed extract (OISE) in prediabetic mice...
January 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28043816/prediabetes-and-cardiovascular-complications-screening-in-nigeria-a-family-case-presentation
#16
Anayochukwu Edward Anyasodor, Ezekiel Uba Nwose, Ross Stuart Richards, Phillip Taderera Bwititi, Luke Itietie Mudiaga, Eferhire Aganbi
Metabolic disorders are on the increase globally, and the need for screening remains imperative. This case report is of a 48-year-old man who was screened as dyslipidaemic and on metabolic syndrome prevention, precipitating screening of family relatives. The extended family members (N=11) were invited for screening, of which 4 were hyperglycaemic, 3 had hypercholesterolaemia; and the HDL levels of 6 participants were abnormal. All family members had normal plasma triglyceride levels, and 4 people had high blood pressure...
December 9, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28043586/assessment-of-diabetes-among-tuberculosis-patients-presenting-at-a-tertiary-care-facility-in-pakistan
#17
Muhammad Irfan, Naseem Salahuddin, Qamar Masood, Owais Ahmed, Umme Salama Moosajee, Zahra Hasan
OBJECTIVE/BACKGROUND: Pakistan ranks sixth among high-tuberculosis (TB)-burden countries worldwide and fifth worldwide for diabetes incidence. Although both these factors are independently known, the rate of diabetes among TB patients is not well known. We aimed to determine the prevalence of diabetes among patients with TB presenting at tertiary care health centers in Karachi, Pakistan. METHODS: A total of 216 patients with TB were recruited and their blood samples were taken for testing of glycosylated hemoglobin (HbA1c) and random blood sugar...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28041666/prediabetes-in-pediatric-recipients-of-liver-transplant-mechanism-and-risk-factors
#18
Emily R Perito, Robert H Lustig, Philip Rosenthal
OBJECTIVE: To investigate the role of calcineurin inhibitor exposure and states of insulin resistance-obesity and adolescence-in prediabetes after pediatric liver transplant via oral glucose tolerance testing, which previously has not been done systematically in these at-risk youths. STUDY DESIGN: This was a cross-sectional study of 81 pediatric recipients of liver transplant. Prediabetes was defined as impaired glucose tolerance (IGT; glucose ≥140 mg/dL at 2 hours) or impaired fasting glucose (IFG, ≥100 mg/dL)...
December 29, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/28040833/insights-into-the-relationships-between-diabetes-prediabetes-and-cancer
#19
REVIEW
Lorenzo Scappaticcio, Maria Ida Maiorino, Giuseppe Bellastella, Dario Giugliano, Katherine Esposito
Diabetes mellitus and cancer are two growing health problems. They have in common many modifiable risk factors including sex, age, obesity, physical activity, diet, alcohol, and smoking, and have a long latency before overtly manifesting. Patients with diabetes experience a roughly 20-25% higher cancer incidence compared to individuals without diabetes, and it depends on cancer site. Moreover, patients with diabetes who further develop cancer have increased early and late mortality in comparison with cancer patients without diabetes...
December 31, 2016: Endocrine
https://www.readbyqxmd.com/read/28031324/overweight-and-obese-but-not-normal-weight-women-with-pcos-are-at-increased-risk-of-type-2-diabetes-mellitus-a-prospective-population-based-cohort-study
#20
M-M E Ollila, S West, S Keinänen-Kiukaanniemi, J Jokelainen, J Auvinen, K Puukka, A Ruokonen, M-R Järvelin, J S Tapanainen, S Franks, T T Piltonen, L C Morin-Papunen
STUDY QUESTION: What are the respective roles of polycystic ovary syndrome (PCOS), long-term weight gain and obesity for the development of prediabetes or Type 2 diabetes mellitus (T2DM) by age 46 years? SUMMARY ANSWER: The risk of T2DM in women with PCOS is mainly due to overweight and obesity, although these two factors have a synergistic effect on the development of T2DM. WHAT IS KNOWN ALREADY: PCOS is associated with an increased risk of prediabetes and T2DM...
December 28, 2016: Human Reproduction
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