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Golden hour

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https://www.readbyqxmd.com/read/29449604/intravenous-synthetic-platelet-synthoplate-nanoconstructs-reduce-bleeding-and-improve-golden-hour-survival-in-a-porcine-model-of-traumatic-arterial-hemorrhage
#1
DaShawn A Hickman, Christa L Pawlowski, Andrew Shevitz, Norman F Luc, Ann Kim, Aditya Girish, Joyann Marks, Simi Ganjoo, Stephanie Huang, Edward Niedoba, Ujjal D S Sekhon, Michael Sun, Mitchell Dyer, Matthew D Neal, Vikram S Kashyap, Anirban Sen Gupta
Traumatic non-compressible hemorrhage is a leading cause of civilian and military mortality and its treatment requires massive transfusion of blood components, especially platelets. However, in austere civilian and battlefield locations, access to platelets is highly challenging due to limited supply and portability, high risk of bacterial contamination and short shelf-life. To resolve this, we have developed an I.V.-administrable 'synthetic platelet' nanoconstruct (SynthoPlate), that can mimic and amplify body's natural hemostatic mechanisms specifically at the bleeding site while maintaining systemic safety...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29440392/structure-function-and-mechanism-of-the-core-circadian-clock-in-cyanobacteria
#2
Jeffrey A Swan, Susan Golden, Andy LiWang, Carrie L Partch
Circadian rhythms enable cells and organisms to coordinate their physiology with the cyclic environmental changes that come as a result of Earth's light/dark cycles. Cyanobacteria make use of a post-translational oscillator (PTO) to maintain circadian rhythms, and this elegant system has become an important model for the post-translational timing mechanisms. Comprised of three proteins, the KaiABC system undergoes an oscillatory biochemical cycle that provides timing cues to achieve a 24-hour molecular clock...
February 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29377268/elevated-donor-plasminogen-activator-inhibitor-1-levels-and-the-risk-of-primary-graft-dysfunction
#3
Barbara C S Hamilton, Gabriela R Dincheva, Hanjing Zhuo, Jeffrey A Golden, Marek Brzezinski, Jonathan P Singer, Michael A Matthay, Jasleen Kukreja
Primary graft dysfunction (PGD) following lung transplantation is associated with elevated recipient plasma levels of plasminogen activator inhibitor-1 (PAI-1) and the receptor for advanced glycation end-products (RAGE). However, the significance of these biomarkers in the donor plasma is uncertain. We hypothesized that elevated donor plasma levels of PAI-1 and RAGE would be associated with recipient PGD. We carried out a prospective unmatched case-control study of double lung transplant recipients between May 2014 and September 2015...
January 29, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29336762/r-a-cowley-the-golden-hour-the-momentary-pause-and-the-third-space
#4
David E Clark
R Adams Cowley (1917-1991), the Baltimore thoracic and trauma surgeon, was an outstanding politician and promoter of emergency medical services. His skills included the effective use of language, for example, identifying the critical time immediately after injury as a "golden hour," and describing shock as a "momentary pause in the act of death." Conversely, Cowley avoided the tendency of some contemporaries to justify massive crystalloid infusion by invoking a "third space." Cowley is often assumed to have originated the first two phrases, but, in fact, their histories go back at least to the 19th century and illustrate the development of surgical science...
December 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29329188/the-impact-of-combined-warm-ischemia-time-on-development-of-acute-kidney-injury-in-donation-after-circulatory-death-liver-transplantation-stay-within-the-golden-hour
#5
Marit Kalisvaart, Andrea Schlegel, Ilaria Umbro, Jubi E de Haan, Irene Scalera, Wojciech G Polak, Jan Nm IJzermans, Darius F Mirza, M Thamara Pr Perera, John I Isaac, James Ferguson, Anna Paola Mitterhofer, Jeroen de Jonge, Paolo Muiesan
BACKGROUND: Acute kidney injury (AKI) is a common complication after liver transplantation and more frequently observed when high-risk grafts, such as DCD grafts are used. Our aim was to investigate the impact of the ischemia periods on development of AKI in DCD liver transplantation. METHODS: We performed a 2-center retrospective study with 368 DCD graft-recipients. Donor warm ischemia time (DWIT) was divided into agonal phase (withdrawal of life-support - cardiac arrest) and asystolic phase (cardiac arrest - start cold perfusion)...
January 11, 2018: Transplantation
https://www.readbyqxmd.com/read/29262428/bringing-emergency-neurology-to-ambulances-mobile-stroke-unit
#6
Ritvij Bowry, James C Grotta
Ischemic stroke results from blocked arteries in the brain, with earlier thrombolysis with intravenous tissue plasminogen activator (tPA) and/or mechanical thrombectomy resulting in improved clinical outcomes. Mobile Stroke Unit (MSU) can speed up the treatment with tPA and facilitate faster triage for patients to hospitals for mechanical thrombectomy. The first registry-based MSU study in Germany demonstrated faster treatment times with tPA using a MSU, a higher proportion of patients being treated within the first "golden hour," and a suggestion of improved 3-month clinical outcomes...
December 2017: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29248468/suspected-anaphylaxis-and-lack-of-clinical-protection-associated-with-envenomation-in-two-dogs-previously-vaccinated-with-crotalus-atrox-toxoid
#7
Kaelyn E Petras, Raegan J Wells, Jocelyn Pronko
OBJECTIVE: to describe the clinical presentation of two canines present in anaphylactic shock secondary to rattlesnake envenomation. In both cases, there was no previous documented previous envenomation event and the initial sensitization required for anaphylactic response is believed to be secondary to Crotalus atrox toxoid vaccine. CASE DESCRIPTION: In the first case, a 12-year-old golden retriever present for collapse, severe hematochezia, and vomiting after first time envenomation from a suspected western diamondback rattlesnake...
December 14, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29223210/providing-evidence-based-care-during-the-golden-hour
#8
Jennifer L Neczypor, Sharon L Holley
The Golden Hour encompasses a set of evidence-based practices that contribute to the physiologic stabilization of the mother-newborn dyad after birth. Important elements of the Golden Hour include delayed cord clamping, skin-to-skin contact for at least an hour, the performance of newborn assessments on the maternal abdomen, delaying non-urgent tasks (e.g., bathing the newborn) for 60 minutes, and the early initiation of breastfeeding. The Golden Hour contributes to neonatal thermoregulation, decreased stress levels in a woman and her newborn, and improved mother-newborn bonding...
December 2017: Nursing for Women's Health
https://www.readbyqxmd.com/read/29199329/-effect-of-a-non-thermal-atmospheric-pressure-argon-plasma-jet-on-sod-and-mda-levels-in-oral-mucosal-ulcer-of-golden-hamsters
#9
Li Zheng, Ming-Sheng Chen, Lu Wang
PURPOSE:To observe the effects of a non-thermal atmospheric pressure argon plasma jet on the healing time, and the levels of superoxide dismutase(SOD)and malondialdehyde(MDA)in oral mucosal ulcer of golden hamsters.METHODS: 56 golden hamsters were randomly assigned to 8 groups, one normal control group, one ulcer group, one natural healing group without any therapy, one iodine glycerin group, two argon groups (30 s, 120 s)and two plasma groups (30 s, 120 s).24 hours after the last treatment, 4 hamsters from each group were sacrificed to detect SOD and MDA levels in the oral mucosal ulcer by spectrophotometry...
August 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29193159/investigation-of-the-quality-of-stored-red-blood-cells-after-simulated-air-drop-in-the-maritime-environment
#10
Athinoula Meli, Vicky Hancock, Heidi Doughty, Steve Smedley, Rebecca Cardigan, Michael Wiltshire
BACKGROUND: Maritime medical capability may be compromised by blood resupply. Air-dropped red blood cells (RBCs) is a possible mitigation factor. This study set out to evaluate RBC storage variables after a simulated parachute air drop into the sea, as limited data exist. STUDY DESIGN AND METHODS: The air load construction for the air drop of blood was subject to static drop assessment to simulate a worst-case parachute drop scenario. One control and two test Golden Hour shipping containers were each packaged with 10 RBC units...
November 27, 2017: Transfusion
https://www.readbyqxmd.com/read/29170318/21%C3%A2-daily-dynamic-discharge-a-whole-system-solution-to-ed-crowding
#11
Jacques Kerr, Helen Maitland, Claire Bell, Julie White, Alan Hunter
INTRODUCTION: ED crowding is associated with increased mortality, poor staff and patient experience, an increased inpatient length of stay and poor compliance with the four-hour emergency access standard.1 Where crowding is caused by exit block, the focus needs to be on whole system patient management, reducing the temporal mismatch between admissions and discharges since at times of peak demand hospitals may become gridlocked until patients are discharged.In an attempt to tackle exit block, the Scottish Government Unscheduled Care Team have implemented the Daily Dynamic Discharge (DDD) approach, which aims to increase the number of inpatient discharges by 12 pm, thus enabling more timeous flow through the ED...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29112280/characterization-and-correlates-of-exercise-among-adolescents-with-anorexia-nervosa-and-bulimia-nervosa
#12
Jason M Nagata, Jennifer L Carlson, Jessica M Kao, Neville H Golden, Stuart B Murray, Rebecka Peebles
OBJECTIVE: To characterize exercise behaviors among adolescents with anorexia nervosa (AN), atypical AN, or bulimia nervosa (BN), and determine associations between exercise and medical risk. STUDY DESIGN: Cross-sectional electronic medical records of all patients evaluated by the Eating Disorder Program at Stanford between January 1997 and February 2011 were retrospectively reviewed. RESULTS: 1,083 subjects (961 females, 122 males; mean age 15...
November 7, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29084225/darker-eggs-of-mosquitoes-resist-more-to-dry-conditions-melanin-enhances-serosal-cuticle-contribution-in-egg-resistance-to-desiccation-in-aedes-anopheles-and-culex-vectors
#13
Luana C Farnesi, Helena C M Vargas, Denise Valle, Gustavo L Rezende
Mosquito vectors lay their white eggs in the aquatic milieu. During early embryogenesis water passes freely through the transparent eggshell, which at this moment is composed of exochorion and endochorion. Within two hours the endochorion darkens via melanization but even so eggs shrink and perish if removed from moisture. However, during mid-embryogenesis, cells of the extraembryonic serosa secrete the serosal cuticle, localized right below the endochorion, becoming the third and innermost eggshell layer. Serosal cuticle formation greatly reduces water flow and allows egg survival outside the water...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29040202/re-examination-of-a-battlefield-trauma-golden-hour-policy
#14
Jeffrey T Howard, Russ S Kotwal, Alexis R Santos, Matthew J Martin, Zsolt T Stockinger
BACKGROUND: Most combat casualties who die, do so in the prehospital setting. Efforts directed toward alleviating prehospital combat trauma death, known as killed in action (KIA) mortality, have the greatest opportunity for eliminating preventable death. METHODS: 4,542 military casualties injured in Afghanistan from September 11, 2001 to March 31, 2014 were included in this retrospective analysis to evaluate proposed explanations for observed KIA reduction following a mandate by Secretary of Defense Robert M...
October 16, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29016592/availability-of-life-support-equipment-and-its-utilization-by-ambulance-drivers
#15
Rija Acharya, Angur Badhu, Tara Shah, Sharmila Shrestha
BACKGROUND: An effective ambulance is a vital requirement for providing an emergency medical service. Well-equipped ambulances with trained paramedics can save many lives during the golden hours of trauma care. The objective was to document the availability and utilization of basic life support equipment in the ambulances and to assess knowledge on first aid among the drivers. METHODS: Descriptive design was used. Total of 109 ambulances linked to B.P. Koirala Institute of Health Sciences were enrolled using purposive sampling method...
September 8, 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28979634/delayed-brachial-artery-reconstruction-after-traumatic-injury-a-case-for-sustainment-of-surgical-intervention
#16
Kelechi Emmanuel Okonta, Emmanuel Ossai Ocheli, Tombari Joseph Gbeneol
The brachial artery is the commonest artery injured in the extremities. Although the patients present late, nevertheless reconstructions is advocated in other to salvage the limb and maintain function of the hand. We retrospectively examined 25 consecutive patients with vascular injuries treated at The Cardiovascular and Thoracic Surgery Unit of a tertiary health centre over a period of 4 years. We assessed the pre-tertiary methods of stopping of bleeding injured brachial arteries, mechanisms of injury, associated injuries, treatment and the outcome following vascular repair in terms of functionality of the forearm and the volume of the radial pulsation...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28958368/assessment-and-resuscitation-in-trauma-management
#17
REVIEW
Stephen Gondek, Mary E Schroeder, Babak Sarani
The golden hour of trauma represents a crucial period in the management of acute injury. In an efficient trauma resuscitation, the primary survey is viewed as more than simple ABCs with multiple processes running in parallel. Resuscitation efforts should be goal oriented with defined endpoints for airway management, access, and hemodynamic parameters. In tandem with resuscitation, early identification of life-threatening injuries is critical for determining the disposition of patients when they leave the trauma bay...
October 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/28932408/golden-hour-of-neonatal-life-need-of-the-hour
#18
REVIEW
Deepak Sharma
"Golden Hour" of neonatal life is defined as the first hour of post-natal life in both preterm and term neonates. This concept in neonatology has been adopted from adult trauma where the initial first hour of trauma management is considered as golden hour. The "Golden hour" concept includes practicing all the evidence based intervention for term and preterm neonates, in the initial sixty minutes of postnatal life for better long-term outcome. Although the current evidence supports the concept of golden hour in preterm and still there is no evidence seeking the benefit of golden hour approach in term neonates, but neonatologist around the globe feel the importance of golden hour concept equally in both preterm and term neonates...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/28915168/fluid-management-in-sepsis-is-there-a-golden-hour-or-two
#19
Katherine L Nugent, Craig M Coopersmith
No abstract text is available yet for this article.
October 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28912650/the-effects-combining-cryocompression-therapy-following-an-acute-bout-of-resistance-exercise-on-performance-and-recovery
#20
William H DuPont, Brek J Meuris, Vincent H Hardesty, Emily C Barnhart, Landon H Tompkins, Morricia J P Golden, Clayton J Usher, Paul A Spence, Lydia K Caldwell, Emily M Post, Matthew K Beeler, William J Kraemer
Compression and cold therapy used separately have shown to reduce negative effects of tissue damage. The combining compression and cold therapy (cryocompression) as a single recovery modality has yet to be fully examined. To examine the effects of cryocompression on recovery following a bout of heavy resistance exercise, recreationally resistance trained men (n =16) were recruited, matched, and randomly assigned to either a cryocompression group (CRC) or control group (CON). Testing was performed before and then immediately after exercise, 60 minutes, 24 hours, and 48 hours after a heavy resistance exercise workout (barbell back squats for 4 sets of 6 reps at 80% 1RM, 90 sec rest between sets, stiff legged deadlifts for 4 sets of 8 reps at 1...
September 2017: Journal of Sports Science & Medicine
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