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https://www.readbyqxmd.com/read/29643063/evaluation-of-prexasertib-a-checkpoint-kinase-1-inhibitor-in-a-phase-ib-study-of-patients-with-squamous-cell-carcinoma
#1
David S Hong, Kathleen N Moore, Manish R Patel, Stefan C Grant, Howard A Burris, William N William, Suzanne Jones, Funda Meric-Bernstam, Jeffrey Infante, Lisa Golden, Wei Zhang, Ricardo Martinez, Sameera R Wijayawardana, Richard P Beckmann, Aimee Bence Lin, Cathy Eng, Johanna C Bendell
PURPOSE: Prexasertib, a checkpoint kinase 1 inhibitor, demonstrated single-agent activity in patients with advanced squamous cell carcinoma (SCC) in the dose-escalation portion of a Phase I study (NCT01115790). Monotherapy prexasertib was further evaluated in patients with advanced SCC. EXPERIMENTAL DESIGN: Patients were given prexasertib 105 mg/m2 as a 1-hour infusion on day 1 of a 14-day cycle. Expansion cohorts were defined by tumor and treatment line. Safety, tolerability, efficacy, and exploratory biomarkers were analyzed...
April 11, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29624558/a-phase-1-pharmacokinetic-and-safety-study-of-extended-duration-high-dose-cefixime-for-cephalosporin-resistant-neisseria-gonorrhoeae-in-the-pharynx
#2
Lindley A Barbee, Seema U Nayak, Jeffrey L Blumer, Mary Ann O'Riordan, Wesley Gray, Jonathan M Zenilman, Matthew R Golden, J McLeod Griffiss
BACKGROUND: There are no fully oral recommended treatment regimens for gonorrhea. Inadequately treated pharyngeal gonococcal infections are a likely reservoir for transmission and development of antimicrobial resistance. We sought to determine an oral cefixime dosing regimen that would theoretically treat pharyngeal infections by gonococci with MICs 0.5μg/mL. METHODS: We conducted an open label, non-randomized, Phase I pharmacokinetic and safety study of cefixime in 25 healthy male and female volunteers divided into four dosing cohorts (Cohort A, 400 mg; Cohort B, 800 mg; Cohort C, 1200 mg; and Cohort D, 800 mg q8h x 3 doses [total dose 2400mg]) with a target serum concentration of ≥2...
April 5, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29610867/golden-hour-great-lawn-central-park
#3
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29527311/development-and-validation-of-a-prediction-model-for-insulin-associated-hypoglycemia-in-non-critically-ill-hospitalized-adults
#4
Nestoras Nicolas Mathioudakis, Estelle Everett, Shuvodra Routh, Peter J Pronovost, Hsin-Chieh Yeh, Sherita Hill Golden, Suchi Saria
Objective: To develop and validate a multivariable prediction model for insulin-associated hypoglycemia in non-critically ill hospitalized adults. Research design and methods: We collected pharmacologic, demographic, laboratory, and diagnostic data from 128 657 inpatient days in which at least 1 unit of subcutaneous insulin was administered in the absence of intravenous insulin, total parenteral nutrition, or insulin pump use (index days). These data were used to develop multivariable prediction models for biochemical and clinically significant hypoglycemia (blood glucose (BG) of ≤70 mg/dL and <54 mg/dL, respectively) occurring within 24 hours of the index day...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29474335/the-golden-hours-of-icu-sedation-the-clock-is-ticking
#5
Yahya Shehabi
No abstract text is available yet for this article.
March 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29460672/effects-of-distance-and-rescue-time-to-medical-facilities-on-traffic-mortality-utilizing-gis
#6
Wei Hu, Qiao Dong, Baoshan Huang
Although supported by little scientific evidence, the concept of 'golden hour,' which claims that mortality for trauma patients rises significantly over rescue time, plays a vital role in the design of our current trauma system. Only the contrary results could be found by using Fatality Analysis Reporting System data from 2010 to 2012. The results of logistic regression showed that longer total time intervals were associated with lower traffic mortality, with an odds ratio (OR) of 0.993 per minute. Utilizing the closest facility solver in the Geographic Information System, the effect of 'reverse causation' and the difference between trauma centre and non-trauma centre on the time-mortality relationship were discussed...
February 20, 2018: International Journal of Injury Control and Safety Promotion
https://www.readbyqxmd.com/read/29455683/defining-ct-perfusion-thresholds-for-infarction-in-the-golden-hour-and-with-ultra-early-reperfusion
#7
Mohamed Najm, Fahad S Al-Ajlan, Mari E Boesen, Lisa Hur, Chi Kyung Kim, Enrico Fainardi, Michael D Hill, Andrew M Demchuk, Mayank Goyal, Ting Y Lee, Bijoy K Menon
In this brief report, computed tomography perfusion (CTP) thresholds predicting follow-up infarction in patients presenting 20 to 23 seconds and cerebral blood flow <5 to 7 ml/min-1/(100 g)-1 or relative cerebral blood flow <0.14 to 0.20 optimally predicted the final infarct. These thresholds are stricter than published thresholds.
February 19, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29449604/intravenous-synthetic-platelet-synthoplate-nanoconstructs-reduce-bleeding-and-improve-golden-hour-survival-in-a-porcine-model-of-traumatic-arterial-hemorrhage
#8
DaShawn A Hickman, Christa L Pawlowski, Andrew Shevitz, Norman F Luc, Ann Kim, Aditya Girish, Joyann Marks, Simi Ganjoo, Stephanie Huang, Edward Niedoba, Ujjal D S Sekhon, Michael Sun, Mitchell Dyer, Matthew D Neal, Vikram S Kashyap, Anirban Sen Gupta
Traumatic non-compressible hemorrhage is a leading cause of civilian and military mortality and its treatment requires massive transfusion of blood components, especially platelets. However, in austere civilian and battlefield locations, access to platelets is highly challenging due to limited supply and portability, high risk of bacterial contamination and short shelf-life. To resolve this, we have developed an I.V.-administrable 'synthetic platelet' nanoconstruct (SynthoPlate), that can mimic and amplify body's natural hemostatic mechanisms specifically at the bleeding site while maintaining systemic safety...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29440392/structure-function-and-mechanism-of-the-core-circadian-clock-in-cyanobacteria
#9
Jeffrey A Swan, Susan Golden, Andy LiWang, Carrie L Partch
Circadian rhythms enable cells and organisms to coordinate their physiology with the cyclic environmental changes that come as a result of Earth's light/dark cycles. Cyanobacteria make use of a post-translational oscillator (PTO) to maintain circadian rhythms, and this elegant system has become an important model for the post-translational timing mechanisms. Comprised of three proteins, the KaiABC system undergoes an oscillatory biochemical cycle that provides timing cues to achieve a 24-hour molecular clock...
February 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29377268/elevated-donor-plasminogen-activator-inhibitor-1-levels-and-the-risk-of-primary-graft-dysfunction
#10
Barbara C S Hamilton, Gabriela R Dincheva, Hanjing Zhuo, Jeffrey A Golden, Marek Brzezinski, Jonathan P Singer, Michael A Matthay, Jasleen Kukreja
Primary graft dysfunction (PGD) following lung transplantation is associated with elevated recipient plasma levels of plasminogen activator inhibitor-1 (PAI-1) and the receptor for advanced glycation end-products (RAGE). However, the significance of these biomarkers in the donor plasma is uncertain. We hypothesized that elevated donor plasma levels of PAI-1 and RAGE would be associated with recipient PGD. We carried out a prospective unmatched case-control study of double lung transplant recipients between May 2014 and September 2015...
January 29, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29336762/r-a-cowley-the-golden-hour-the-momentary-pause-and-the-third-space
#11
David E Clark
R Adams Cowley (1917-1991), the Baltimore thoracic and trauma surgeon, was an outstanding politician and promoter of emergency medical services. His skills included the effective use of language, for example, identifying the critical time immediately after injury as a "golden hour," and describing shock as a "momentary pause in the act of death." Conversely, Cowley avoided the tendency of some contemporaries to justify massive crystalloid infusion by invoking a "third space." Cowley is often assumed to have originated the first two phrases, but, in fact, their histories go back at least to the 19th century and illustrate the development of surgical science...
December 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29329188/the-impact-of-combined-warm-ischemia-time-on-development-of-acute-kidney-injury-in-donation-after-circulatory-death-liver-transplantation-stay-within-the-golden-hour
#12
Marit Kalisvaart, Andrea Schlegel, Ilaria Umbro, Jubi E de Haan, Irene Scalera, Wojciech G Polak, Jan Nm IJzermans, Darius F Mirza, M Thamara Pr Perera, John I Isaac, James Ferguson, Anna Paola Mitterhofer, Jeroen de Jonge, Paolo Muiesan
BACKGROUND: Acute kidney injury (AKI) is a common complication after liver transplantation and more frequently observed when high-risk grafts, such as DCD grafts are used. Our aim was to investigate the impact of the ischemia periods on development of AKI in DCD liver transplantation. METHODS: We performed a 2-center retrospective study with 368 DCD graft-recipients. Donor warm ischemia time (DWIT) was divided into agonal phase (withdrawal of life-support - cardiac arrest) and asystolic phase (cardiac arrest - start cold perfusion)...
January 11, 2018: Transplantation
https://www.readbyqxmd.com/read/29262428/bringing-emergency-neurology-to-ambulances-mobile-stroke-unit
#13
Ritvij Bowry, James C Grotta
Ischemic stroke results from blocked arteries in the brain, with earlier thrombolysis with intravenous tissue plasminogen activator (tPA) and/or mechanical thrombectomy resulting in improved clinical outcomes. Mobile Stroke Unit (MSU) can speed up the treatment with tPA and facilitate faster triage for patients to hospitals for mechanical thrombectomy. The first registry-based MSU study in Germany demonstrated faster treatment times with tPA using a MSU, a higher proportion of patients being treated within the first "golden hour," and a suggestion of improved 3-month clinical outcomes...
December 2017: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29248468/suspected-anaphylaxis-and-lack-of-clinical-protection-associated-with-envenomation-in-two-dogs-previously-vaccinated-with-crotalus-atrox-toxoid
#14
Kaelyn E Petras, Raegan J Wells, Jocelyn Pronko
OBJECTIVE: to describe the clinical presentation of two canines present in anaphylactic shock secondary to rattlesnake envenomation. In both cases, there was no previous documented previous envenomation event and the initial sensitization required for anaphylactic response is believed to be secondary to Crotalus atrox toxoid vaccine. CASE DESCRIPTION: In the first case, a 12-year-old golden retriever present for collapse, severe hematochezia, and vomiting after first time envenomation from a suspected western diamondback rattlesnake...
February 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29223210/providing-evidence-based-care-during-the-golden-hour
#15
Jennifer L Neczypor, Sharon L Holley
The Golden Hour encompasses a set of evidence-based practices that contribute to the physiologic stabilization of the mother-newborn dyad after birth. Important elements of the Golden Hour include delayed cord clamping, skin-to-skin contact for at least an hour, the performance of newborn assessments on the maternal abdomen, delaying non-urgent tasks (e.g., bathing the newborn) for 60 minutes, and the early initiation of breastfeeding. The Golden Hour contributes to neonatal thermoregulation, decreased stress levels in a woman and her newborn, and improved mother-newborn bonding...
December 2017: Nursing for Women's Health
https://www.readbyqxmd.com/read/29199329/-effect-of-a-non-thermal-atmospheric-pressure-argon-plasma-jet-on-sod-and-mda-levels-in-oral-mucosal-ulcer-of-golden-hamsters
#16
Li Zheng, Ming-Sheng Chen, Lu Wang
PURPOSE:To observe the effects of a non-thermal atmospheric pressure argon plasma jet on the healing time, and the levels of superoxide dismutase(SOD)and malondialdehyde(MDA)in oral mucosal ulcer of golden hamsters.METHODS: 56 golden hamsters were randomly assigned to 8 groups, one normal control group, one ulcer group, one natural healing group without any therapy, one iodine glycerin group, two argon groups (30 s, 120 s)and two plasma groups (30 s, 120 s).24 hours after the last treatment, 4 hamsters from each group were sacrificed to detect SOD and MDA levels in the oral mucosal ulcer by spectrophotometry...
August 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29193159/investigation-of-the-quality-of-stored-red-blood-cells-after-simulated-air-drop-in-the-maritime-environment
#17
Athinoula Meli, Vicky Hancock, Heidi Doughty, Steve Smedley, Rebecca Cardigan, Michael Wiltshire
BACKGROUND: Maritime medical capability may be compromised by blood resupply. Air-dropped red blood cells (RBCs) is a possible mitigation factor. This study set out to evaluate RBC storage variables after a simulated parachute air drop into the sea, as limited data exist. STUDY DESIGN AND METHODS: The air load construction for the air drop of blood was subject to static drop assessment to simulate a worst-case parachute drop scenario. One control and two test Golden Hour shipping containers were each packaged with 10 RBC units...
February 2018: Transfusion
https://www.readbyqxmd.com/read/29170318/21-daily-dynamic-discharge-a-whole-system-solution-to-ed-crowding
#18
Jacques Kerr, Helen Maitland, Claire Bell, Julie White, Alan Hunter
INTRODUCTION: ED crowding is associated with increased mortality, poor staff and patient experience, an increased inpatient length of stay and poor compliance with the four-hour emergency access standard.1 Where crowding is caused by exit block, the focus needs to be on whole system patient management, reducing the temporal mismatch between admissions and discharges since at times of peak demand hospitals may become gridlocked until patients are discharged.In an attempt to tackle exit block, the Scottish Government Unscheduled Care Team have implemented the Daily Dynamic Discharge (DDD) approach, which aims to increase the number of inpatient discharges by 12 pm, thus enabling more timeous flow through the ED...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29112280/characterization-and-correlates-of-exercise-among-adolescents-with-anorexia-nervosa-and-bulimia-nervosa
#19
Jason M Nagata, Jennifer L Carlson, Jessica M Kao, Neville H Golden, Stuart B Murray, Rebecka Peebles
OBJECTIVE: To characterize exercise behaviors among adolescents with anorexia nervosa (AN), atypical AN, or bulimia nervosa (BN), and determine associations between exercise and medical risk. STUDY DESIGN: Cross-sectional electronic medical records of all patients evaluated by the Eating Disorder Program at Stanford between January 1997 and February 2011 were retrospectively reviewed. RESULTS: 1,083 subjects (961 females, 122 males; mean age 15...
December 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29084225/darker-eggs-of-mosquitoes-resist-more-to-dry-conditions-melanin-enhances-serosal-cuticle-contribution-in-egg-resistance-to-desiccation-in-aedes-anopheles-and-culex-vectors
#20
Luana C Farnesi, Helena C M Vargas, Denise Valle, Gustavo L Rezende
Mosquito vectors lay their white eggs in the aquatic milieu. During early embryogenesis water passes freely through the transparent eggshell, which at this moment is composed of exochorion and endochorion. Within two hours the endochorion darkens via melanization but even so eggs shrink and perish if removed from moisture. However, during mid-embryogenesis, cells of the extraembryonic serosa secrete the serosal cuticle, localized right below the endochorion, becoming the third and innermost eggshell layer. Serosal cuticle formation greatly reduces water flow and allows egg survival outside the water...
October 2017: PLoS Neglected Tropical Diseases
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