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JOURNAL ARTICLE
Jessica Nolan, Michael Bynevelt, Erin Godecke, Angela Jacques, Ferry Dharsono, Barbara Singer
BACKGROUND: Post-stroke lateropulsion is prevalent and has been associated with varied lesion locations, but existing imaging studies are limited by small participant cohorts. Evidence to guide lateropulsion rehabilitation is also limited. Improved understanding of lesion localization associated with lateropulsion post-stroke may inform more targeted intervention approaches. OBJECTIVES: This study investigated the associations between stroke neuroimaging data and presence of lateropulsion at inpatient rehabilitation admission...
April 10, 2024: Topics in Stroke Rehabilitation
#22
EDITORIAL
Rui Moreno, Mervyn Singer, Andrew Rhodes
No abstract text is available yet for this article.
2024: Crit Care Sci
#23
JOURNAL ARTICLE
Nicholas Santoro, David M Singer, Bridget K Mulvey, Katrina Halasa, Nadya Teutsch, Allie Shedleski, Madison Wood
Lead (Pb) poses a significant risk to infants and children through exposure to contaminated soil and dust. However, there is a lack of information on Pb speciation and distribution at the neighborhood-scale. This work aimed to determine: (1) the distribution of acid-extractable (labile) Pb and other metals ([M]AE ) in two neighborhoods in Akron, Ohio (USA) (Summit Lake and West Akron; n = 82 samples); and (2) Pb speciation and potential sources. Total metal concentration ([M]T ) and [M]AE was strongly correlated for Pb and Zn (R2 of 0...
April 9, 2024: Environmental Geochemistry and Health
#24
JOURNAL ARTICLE
Ronald W Singer
Background: Total knee arthroplasty (TKA) is one of the most common inpatient and outpatient surgical procedures performed in the United States and is predicted to increase 401% by 2040. Surgical site infections (SSIs) at an incidence rate of approximately 2% are costly post-operative complications in TKA. Intra-operative surgical irrigants are used to decrease contaminating microbial bioburden within the surgical site to prevent SSI. The primary objective of this retrospective study was to evaluate the impact of a novel surgical irrigant called XPERIENCE® Advanced Surgical Irrigation (XP; Next Science, Jacksonville, FL) on SSI incidence in primary TKA performed at an ambulatory surgery center (ASC)...
April 2024: Surgical Infections
#25
JOURNAL ARTICLE
Alicia M Schowe, Malvika Godara, Darina Czamara, Mazda Adli, Tania Singer, Elisabeth B Binder
The coronavirus disease 2019 (COVID-19) pandemic was accompanied by an increase in mental health challenges including depression, stress, loneliness, and anxiety. Common genetic variants can contribute to the risk for psychiatric disorders and may present a risk factor in times of crises. However, it is unclear to what extent polygenic risk played a role in the mental health response to the COVID-19 pandemic. In this study, we investigate whether polygenic scores (PGSs) for mental health-related traits can distinguish between four resilience-vulnerability trajectories identified during the COVID-19 pandemic and associated lockdowns in 2020/21...
April 8, 2024: European Archives of Psychiatry and Clinical Neuroscience
#26
JOURNAL ARTICLE
Afshana Quadiri, Swayam Prakash, Nisha Rajeswari Dhanushkodi, Mahmoud Singer, Latifa Zayou, Amin Mohammed Shaik, Miyo Sun, Berfin Suzer, Lauren Su Lin Lau, Amruth Chilukurri, Hawa Vahed, Hubert Schaefer, Lbachir BenMohamed
Following acute herpes simplex virus type 2 (HSV-2) infection, the virus undergoes an asymptomatic latent infection of sensory neurons of dorsal root ganglia (DRG). Chemical and physical stress cause intermittent virus reactivation from latently infected DRG and recurrent virus shedding in the genital mucosal epithelium causing genital herpes in symptomatic patients. While T cells appear to play a role in controlling virus reactivation from DRG and reducing the severity of recurrent genital herpes, the mechanisms for recruiting these T cells into DRG and the vaginal mucosa (VM) remain to be fully elucidated...
April 8, 2024: Journal of Virology
#27
Julie A Jurgens, Brenda J Barry, Wai-Man Chan, Sarah MacKinnon, Mary C Whitman, Paola M Matos Ruiz, Brandon M Pratt, Eleina M England, Lynn Pais, Gabrielle Lemire, Emily Groopman, Carmen Glaze, Kathryn A Russell, Moriel Singer-Berk, Silvio Alessandro Di Gioia, Arthur S Lee, Caroline Andrews, Sherin Shaaban, Megan M Wirth, Sarah Bekele, Melissa Toffoloni, Victoria R Bradford, Emma E Foster, Lindsay Berube, Cristina Rivera-Quiles, Fiona M Mensching, Alba Sanchis-Juan, Jack M Fu, Isaac Wong, Xuefang Zhao, Michael W Wilson, Ben Weisburd, Monkol Lek, Harrison Brand, Michael E Talkowski, Daniel G MacArthur, Anne O'Donnell-Luria, Caroline D Robson, David G Hunter, Elizabeth C Engle
PURPOSE: To identify genetic etiologies and genotype/phenotype associations for unsolved ocular congenital cranial dysinnervation disorders (oCCDDs). METHODS: We coupled phenotyping with exome or genome sequencing of 467 pedigrees with genetically unsolved oCCDDs, integrating analyses of pedigrees, human and animal model phenotypes, and de novo variants to identify rare candidate single nucleotide variants, insertion/deletions, and structural variants disrupting protein-coding regions...
March 26, 2024: medRxiv
#28
REVIEW
Matthias Büttner, Susanne Singer, Katherine Taylor
PURPOSE: Hypoparathyroidism is defined by hypocalcemia with inappropriately normal or low parathyroid hormone levels. The current standard treatment consists of lifelong calcium and/ or vitamin D supplementation. Even while on stable treatment regimens, hypoparathyroid patients might still suffer from symptoms that can negatively impact their quality of life. METHODS: A systematic literature review to identify the current knowledge regarding quality of life in patients with hypoparathyroidism receiving standard treatment was performed on November 1st, 2023...
April 5, 2024: Endocrine
#29
JOURNAL ARTICLE
Michal Danino-Levi, Tal Goldberg, Maya Keter, Nikol Akselrod, Noa Shprach-Buaron, Modi Safra, Gonen Singer, Shahar Alon
Cancer cells can manipulate immune cells and escape from the immune system response. Quantifying the molecular changes that occur when an immune cell is touching a tumor cell can increase our understanding of the underlying mechanisms. Recently, it became possible to perform such measurements in situ, for example using expansion sequencing, which enabled in situ sequencing of genes with super-resolution. We systematically examined whether individual immune cells from specific cell types express genes differently when in physical proximity to individual tumor cells...
April 4, 2024: RNA
#30
JOURNAL ARTICLE
Walison Augusto da Silva Brito, Mehdi Ravandeh, Fariba Saadati, Debora Singer, Anna Daniela Dorsch, Anke Schmidt, Alessandra Lourenço Cecchini, Kristian Wende, Sander Bekeschus
The environmental presence of nano- and micro-plastic particles (NMPs) is suspected to have a negative impact on human health. Environmental NMPs are difficult to sample and use in life science research, while commercially available plastic particles are too morphologically uniform. Additionally, this NMPs exposure exhibited biological effects, including cell internalization, oxidative stress, inflammation, cellular adaptation, and genotoxicity. Therefore, developing new methods for producing heterogenous NMPs as observed in the environment is important as reference materials for research...
April 2, 2024: Chemosphere
#31
JOURNAL ARTICLE
Taylor Goodstein, Ilana Goldberg, Yusuf Acikgoz, Elshad Hasanov, Ramaprasad Srinivasan, Eric A Singer
PURPOSE OF REVIEW: This review focuses on special populations poorly represented in current evidence-based practice for metastatic renal cell carcinoma (mRCC). This includes the elderly and frail, patients on immunosuppression or with autoimmune diseases, patients with brain, liver, and/or bone metastases, and RCC with sarcomatoid features. RECENT FINDINGS: Certain populations are poorly represented in current trials for mRCC. Patients with central nervous system (CNS) metastases are often excluded from first-line therapy trials...
May 1, 2024: Current Opinion in Oncology
#32
JOURNAL ARTICLE
Iakovos Saridakis, Margaux Riomet, Oliver J V Belleza, Guilhem Coussanes, Nadja K Singer, Nina Kastner, Yi Xiao, Elliot Smith, Veronica Tona, Aurélien de la Torre, Eric F Lopes, Pedro A Sánchez-Murcia, Leticia González, Harald H Sitte, Nuno Maulide
The deployment of small-molecule fluorescent agents plays an ever-growing role in medicine and drug development. Herein, we complement the portfolio of powerful fluorophores, reporting the serendipitous discovery and development of a novel class with an imidazo[1,2-a]pyridinium triflate core, which we term PyrAtes. These fluorophores are synthesized in a single step from readily available materials (>60 examples) and display Stokes shifts as large as 240 nm, while also reaching NIR-I emissions at λmax as long as 720 nm...
April 3, 2024: Angewandte Chemie
#33
JOURNAL ARTICLE
Eleni Kanouta, Petr Bruza, Jacob Graversen Johansen, Line Kristensen, Brita Singers Sørensen, Per Rugaard Poulsen
BACKGROUND: Dosimetry in pre-clinical FLASH studies is essential for understanding the beam delivery conditions that trigger the FLASH effect. Resolving the spatial and temporal characteristics of proton pencil beam scanning (PBS) irradiations with ultra-high dose rates (UHDR) requires a detector with high spatial and temporal resolution. PURPOSE: To implement a novel camera-based system for time-resolved two-dimensional (2D) monitoring and apply it in vivo during pre-clinical proton PBS mouse irradiations...
April 3, 2024: Medical Physics
#34
JOURNAL ARTICLE
Gabrielle Lemire, Alba Sanchis-Juan, Kathryn Russell, Samantha Baxter, Katherine R Chao, Moriel Singer-Berk, Emily Groopman, Isaac Wong, Eleina England, Julia Goodrich, Lynn Pais, Christina Austin-Tse, Stephanie DiTroia, Emily O'Heir, Vijay S Ganesh, Monica H Wojcik, Emily Evangelista, Hana Snow, Ikeoluwa Osei-Owusu, Jack Fu, Mugdha Singh, Yulia Mostovoy, Steve Huang, Kiran Garimella, Samantha L Kirkham, Jennifer E Neil, Diane D Shao, Christopher A Walsh, Emanuela Argilli, Carolyn Le, Elliott H Sherr, Joseph G Gleeson, Shirlee Shril, Ronen Schneider, Friedhelm Hildebrandt, Vijay G Sankaran, Jill A Madden, Casie A Genetti, Alan H Beggs, Pankaj B Agrawal, Kinga M Bujakowska, Emily Place, Eric A Pierce, Sandra Donkervoort, Carsten G Bönnemann, Lyndon Gallacher, Zornitza Stark, Tiong Yang Tan, Susan M White, Ana Töpf, Volker Straub, Mark D Fleming, Martin R Pollak, Katrin Õunap, Sander Pajusalu, Kirsten A Donald, Zandre Bruwer, Gianina Ravenscroft, Nigel G Laing, Daniel G MacArthur, Heidi L Rehm, Michael E Talkowski, Harrison Brand, Anne O'Donnell-Luria
Copy number variants (CNVs) are significant contributors to the pathogenicity of rare genetic diseases and, with new innovative methods, can now reliably be identified from exome sequencing. Challenges still remain in accurate classification of CNV pathogenicity. CNV calling using GATK-gCNV was performed on exomes from a cohort of 6,633 families (15,759 individuals) with heterogeneous phenotypes and variable prior genetic testing collected at the Broad Institute Center for Mendelian Genomics of the Genomics Research to Elucidate the Genetics of Rare Diseases consortium and analyzed using the seqr platform...
March 27, 2024: American Journal of Human Genetics
#35
Nathaniel R Bennett, Joseph L Watson, Robert J Ragotte, Andrew J Borst, Déjenaé L See, Connor Weidle, Riti Biswas, Ellen L Shrock, Philip J Y Leung, Buwei Huang, Inna Goreshnik, Russell Ault, Kenneth D Carr, Benedikt Singer, Cameron Criswell, Dionne Vafeados, Mariana Garcia Sanchez, Ho Min Kim, Susana Vázquez Torres, Sidney Chan, David Baker
Despite the central role that antibodies play in modern medicine, there is currently no way to rationally design novel antibodies to bind a specific epitope on a target. Instead, antibody discovery currently involves time-consuming immunization of an animal or library screening approaches. Here we demonstrate that a fine-tuned RFdiffusion network is capable of designing de novo antibody variable heavy chains (VHH's) that bind user-specified epitopes. We experimentally confirm binders to four disease-relevant epitopes, and the cryo-EM structure of a designed VHH bound to influenza hemagglutinin is nearly identical to the design model both in the configuration of the CDR loops and the overall binding pose...
March 18, 2024: bioRxiv
#36
JOURNAL ARTICLE
S Aswathy, S Shyamalagowri, Sowmya Hari, M Kanimozhi, S S Meenambiga, M Thenmozhi, R Karthiyayini, D Suresh, J Manjunathan
In the present study, Pleurotus tuber-regium (Rumph. ex Fr.) Singer collected from Keeriparai forest of Kanyakumari district, South India was cultivated using environmentally benign, low-cost agricultural waste residues (paddy straw, sugarcane bagasse, rice husk, and sawdust) as growth substrates. The main goal of this study was to assess the cultivation, yield, and nutritional value of P. tuber-regium fruiting bodies grown under different growth substrates. Spawn running time and time for primordia formation were found to be shorter in mushroom growing with paddy straw substrate compared to sawdust and sugarcane bagasse...
April 2024: 3 Biotech
#37
JOURNAL ARTICLE
Lucas M Ritschl, Hannes Singer, Franz-Carl Clasen, Bernhard Haller, Andreas M Fichter, Herbert Deppe, Klaus-Dietrich Wolff, Jochen Weitz
INTRODUCTION: Mandibular reconstruction with the free fibula flap (FFF) has become a standardized procedure. The situation is different with oral rehabilitation, so the purpose of this study was to investigate the frequency of implant placement and prosthetic restoration. Additionally, the patients' situation, motivation, and treatment course were structurally assessed. MATERIALS AND METHODS: All cases between January 2013 and December 2018 that underwent mandibular reconstruction in our department with a free fibula flap and gave written informed consent to participate were interviewed with two structured questionnaires about their restoration and quality of life...
2024: Frontiers in Oncology
#38
Amit Singer, Ruiyi Yang
In this paper we propose an algorithm for aligning three-dimensional objects when represented as density maps, motivated by applications in cryogenic electron microscopy. The algorithm is based on minimizing the 1-Wasserstein distance between the density maps after a rigid transformation. The induced loss function enjoys a more benign landscape than its Euclidean counterpart and Bayesian optimization is employed for computation. Numerical experiments show improved accuracy and efficiency over existing algorithms on the alignment of real protein molecules...
March 12, 2024: ArXiv
#39
JOURNAL ARTICLE
Arielle Kaim, Clara Singer, Lucia Bergovoy-Yellin, Osnat Luxenburg, Sharona Vaknin, Noga Boldor, Rachel Wilf-Miron, Vicki Myers
BACKGROUND: Medical imaging tests are vital in healthcare but can be costly, impacting national health expenditures. Magnetic resonance imaging (MRI) is a crucial diagnostic tool for assessing medical conditions. However, the rising demand for MRI scans has frequently strained available resources. This study aimed to estimate the prevalence of different imaging tests in individuals who eventually had an MRI, in the Israeli public health system. METHODS: An online survey of patient experience of scheduling an MRI was conducted in January-February 2023, among 557 Israeli adults, representing all four health maintenance organizations (HMOs)...
April 1, 2024: Israel Journal of Health Policy Research
#40
JOURNAL ARTICLE
Chhayakanta Patro, Angela Monfiletto, Aviya Singer, Nirmal Kumar Srinivasan, Srikanta Kumar Mishra
OBJECTIVES: The objectives of the present study were to investigate the effects of age-related changes in extended high-frequency (EHF) hearing, peripheral neural function, working memory, and executive function on speech perception deficits in middle-aged individuals with clinically normal hearing. DESIGN: We administered a comprehensive assessment battery to 37 participants spanning the age range of 20 to 56 years. This battery encompassed various evaluations, including standard and EHF pure-tone audiometry, ranging from 0...
April 1, 2024: Ear and Hearing
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