Marta Hernández-García, Sergio García-Fernández, María García-Castillo, José Melo-Cristino, Margarida F Pinto, Elsa Gonçalves, Valquíria Alves, Eliana Costa, Elmano Ramalheira, Luísa Sancho, José Diogo, Rui Ferreira, Tânia Silva, Catarina Chaves, Leonor Pássaro, Laura Paixão, João Romano, Rafael Cantón
Ceftolozane-tazobactam (C/T) is frequently used for infections caused by multidrug-resistant (MDR)-Enterobacterales isolates. Whole-genome sequencing (WGS, Illumina-Hiseq 4000/NovaSeq 6000, OGC, UK) was used to study the population structure, the resistome and the virulome of C/T-susceptible and -resistant MDR Escherichia spp. (n=30) and Klebsiella spp. (n=78) isolates, recovered from lower respiratory, intra-abdominal and urinary tract infections of ICU patients from 11 Portuguese Hospitals (STEP study, 2017-2018)...
February 2021: International Journal of Antimicrobial Agents