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https://www.readbyqxmd.com/read/27899312/exploratory-factor-analysis-of-nrg-oncology-s-university-of-washington-quality-of-life-questionnaire-rtog-modification
#1
Stephanie L Pugh, Gwen Wyatt, Raimond K W Wong, Stephen M Sagar, Bevan Yueh, Anurag K Singh, Min Yao, Phuc Felix Nguyen-Tan, Sue S Yom, Francis S Cardinale, Khalil Sultanem, D Ian Hodson, Greg A Krempl, Ariel Chavez, Alexander M Yeh, Deborah W Bruner
CONTEXT: The 15-item University of Washington Quality of Life questionnaire - Radiation Therapy Oncology Group (RTOG) modification (UW-QOL-RTOG modification) has been used in several trials of head and neck cancer conducted by NRG Oncology such as RTOG 9709, RTOG 9901, RTOG 0244, and RTOG 0537. OBJECTIVES: This study is an exploratory factor analysis (EFA) to establish validity and reliability of the instrument subscales. METHODS: EFA on the UW-QOL - RTOG modification was conducted using baseline data from NRG Oncology's RTOG 0537, a trial of acupuncture-like transcutaneous electrical nerve stimulation in treating radiation-induced xerostomia...
November 26, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/27896667/head-and-neck-rhabdomyosarcoma-clinical-and-pathologic-characterization-of-seven-cases
#2
Eleanor Chen, Robert Ricciotti, Neal Futran, Dolphine Oda
Head and neck rhabdomyosarcoma occurs frequently in children and adolescents, and has been well studied in that population. In contrast, it is rare in adults and is not as well characterized clinically and pathologically. Seven cases of adult rhabdomyosarcoma occurring in head and neck were retrieved from the archives of Department of Pathology and Division of Oral Pathology at University of Washington. Radiologic findings and clinical history, as well as pathologic findings from hematoxylin and eosin slides and immunohistochemistry for myogenic markers were reviewed...
November 28, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27884319/student-views-on-the-role-of-self-regulated-learning-in-a-surgery-clerkship
#3
Ariel M Lyons-Warren, John P Kirby, Douglas P Larsen
BACKGROUND: Self-regulated learning, including student-generated learning goals and flexibility in the learning structure are increasingly being used to enhance medical education. The role of these practices in surgical education of medical students has not been studied. MATERIALS AND METHODS: We administered an 18-question electronic survey to all third-year medical students at Washington University in St. Louis School of Medicine. Of the 126 students invited, 64 responded and 56 were included in the analysis...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27879147/pre-transplantation-novel-agent-induction-predicts-progression-free-survival-for-patients-with-immunoglobulin-light-chain-amyloidosis-undergoing-high-dose-melphalan-and-autologous-stem-cell-transplantation
#4
Andrew J Cowan, Zandra K Klippel, Philip A Stevenson, Teresa S Hyun, Sherilyn Tuazon, Pamela S Becker, Damian J Green, Leona A Holmberg, David G Coffey, Ajay K Gopal, Edward N Libby
INTRODUCTION: High-dose melphalan and autologous stem cell transplantation (HDM/SCT) is an effective treatment modality for immunoglobulin light-chain (AL) amyloidosis; however, its application remains restricted to patients with good performance status and limited organ involvement. In recent years, the paradigm for AL amyloidosis has changed with the introduction of novel agents such as immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs). We hypothesized that use of novel agent induction regimens has improved outcomes for patients with AL amyloidosis undergoing HDM/SCT at our center...
December 2016: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/27876377/quality-of-life-in-long-term-oral-cancer-survivors-an-8-year-prospective-study-in-china
#5
Ying-Bin Yan, Li Meng, Zi-Quan Liu, Jia-Bin Xu, Hao Liu, Jun Shen, Xue-Wei Zhang, Xin Peng, Chi Mao
OBJECTIVES: The purpose of the prospective study was to evaluate the long-term changes in quality of life (QOL) in patients with oral cancer and to examine the potential factors that predicted QOL at 8 years after treatment. STUDY DESIGN: Seventy-one patients were evaluated by the University of Washington quality of life scale. QOL in 30 long-term survivors was assessed at diagnosis and at the 3-month, 1-year, and 8-year follow-up. RESULTS: QOL was found to be better among survivors compared with nonsurvivors at the 1-year follow-up...
September 28, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27872524/human-papilloma-virus-in-oral-cavity-cancer-and-relation-to-change-in-quality-of-life-following-treatment-a-pilot-study-from-northern-india
#6
Abhishek Kumar Singh, Jitendra Kumar Kushwaha, Akshay Anand, Abhinav Arun Sonkar, Nuzhat Husain, Kirti Srivastava, Sudhir Singh
Human papilloma virus (HPV)-associated head and neck cancer (HNC) has generated significant amount of research interest in recent times with focus shifted to oral cavity squamous cell cancer (OCSCC) after oropharyngeal cancer. Due to high incidence of OCSCC and anecdotal reports on association of HPV infection from northern region of India, this study was conceived to investigate HPV infection and establish its association with lifestyle habits such as tobacco, alcohol consumption, oro-genital sex, number of sexual contacts, and change in quality of life posttreatment...
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27871967/prevalence-and-etiology-of-hypogonadism-in-young-men-with-chronic-spinal-cord-injury-a-cross-sectional-analysis-from-two-university-based-rehabilitation-centers
#7
Shannon D Sullivan, Mark S Nash, Eshetu Tefera, Emily Tinsley, Marc R Blackman, Suzanne Groah
BACKGROUND: Spinal cord injury (SCI) triggers an 'accelerated aging' process that may include development of hypogonadism, even among younger men with SCI; however, few studies have investigated the prevalence or etiology of hypogonadism in men with SCI. Young men with SCI are also at increased risk for developing metabolic dysfunction after injury, which may be exacerbated by concomitant testosterone (T) deficiency, thus identifying the prevalence and risk factors for T deficiency in men with SCI is important for their long-term health...
November 18, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27871490/predictive-models-for-mortality-after-ruptured-aortic-aneurysm-repair-do-not-predict-futility-and-are-not-useful-for-clinical-decision-making
#8
Patrick C Thompson, Ronald L Dalman, E John Harris, Venita Chandra, Jason T Lee, Matthew W Mell
OBJECTIVE: The clinical decision-making utility of scoring algorithms for predicting mortality after ruptured abdominal aortic aneurysms (rAAAs) remains unknown. We sought to determine the clinical utility of the algorithms compared with our clinical decision making and outcomes for management of rAAA during a 10-year period. METHODS: Patients admitted with a diagnosis rAAA at a large university hospital were identified from 2005 to 2014. The Glasgow Aneurysm Score, Hardman Index, Vancouver Score, Edinburgh Ruptured Aneurysm Score, University of Washington Ruptured Aneurysm Score, Vascular Study Group of New England rAAA Risk Score, and the Artificial Neural Network Score were analyzed for accuracy in predicting mortality...
December 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27866639/innovation-within-a-university-setting
#9
Elisabeth K Wynne, Thomas M Krummel
Elisabeth K. Wynne, MD, completed her undergraduate degree in bioengineering and is currently a surgical resident in training at the University of Washington. From 2014-2016, she served as a Biodesign Fellow at Stanford University. She plans to pursue a career of innovation as an academic surgeon. Thomas M. Krummel, MD, is the Emile Holman Professor and Chair Emeritus of the Department of Surgery at Stanford University School of Medicine. Throughout his career, Dr Krummel has been a pioneer and an innovator...
December 2016: Surgery
https://www.readbyqxmd.com/read/27861384/trends-of-triple-negative-breast-cancer-research-2007-2015-a-bibliometric-study
#10
Yiran Wang, Xiao Zhai, Chuan Liu, Ning Wang, Yajie Wang
BACKGROUND: Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. However, there have been limited data to evaluate the trend of TNBC research. This study aims to investigate the trend of TNBC research and compare the contribution of research from different regions, organizations, and authors. METHODS: TNBC-related publications from 2007 to 2015 were retrieved from the Web of Science database. Excel 2013 (Redmond, Washington, USA), GraphPad Prism 5 (GraphPad Prism Software Inc...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27849216/olfactory-function-and-quality-of-life-after-olfaction-rehabilitation-in-total-laryngectomees
#11
Christiane Gouvêa Dos Santos, Anke Bergmann, Kaliani Lima Coça, Angela Albuquerque Garcia, Tânia Cristina de Oliveira Valente
Purpose: To evaluate the effects of olfaction rehabilitation in the olfactory function and quality of life of total laryngectomized patients. Methods: Pre-post intervention clinical study conducted with total laryngectomees submitted to olfaction rehabilitation by means of the Nasal Airflow-Inducing Maneuver (NAIM) using the University of Pennsylvania Smell Identification Test (UPSIT), Olfactory Acuity Questionnaires, a Monitoring Questionnaire, and the University of Washington Quality of Life Questionnaire (UW-QOL)...
November 16, 2016: CoDAS
https://www.readbyqxmd.com/read/27845620/gerontological-social-work-student-delivered-respite-a-community-university-partnership-pilot-program
#12
Tiffany R Washington, Jacqueline A Tachman
The current study describes a community-university partnership to support a gerontological social work student-delivered respite program, the Houseguest Program (Houseguest). Houseguest was designed using a community-engaged scholarship model of integrating research, teaching, and service. Houseguest was piloted with a small group of community-dwelling, co-residing dementia caregivers and care recipients. We examined caregivers' experiences with student-delivered respite using qualitative data analysis. Thematic analysis produced eight themes: 1) respite from full time caregiving role; 2) information on caregiving strategies; 3) no-cost supportive services; 4) opportunity for care recipients to socialize; 5) tailored activities for care recipients; 6) rapport-building between students and family dyad; 7) reciprocity between students and family dyad; and 8) program continuation...
November 15, 2016: Journal of Gerontological Social Work
https://www.readbyqxmd.com/read/27842779/collaborative-care-for-women-with-depression-a-systematic-review
#13
REVIEW
Hsiang Huang, M Karen Tabb, M Joseph Cerimele, Nahida Ahmed, Amritha Bhat, Rachel Kester
BACKGROUND: The collaborative care model has been found to be effective for depression management in various primary care populations; however, no review has synthesized trials tailored to treat women. OBJECTIVE: The purpose of this systematic review is to evaluate the current evidence for collaborative depression care for women. METHODOLOGY: We searched for English language articles via MEDLINE, CINAHL, PsycINFO, EMBASE, Cochrane Library, and reference lists of key articles...
September 6, 2016: Psychosomatics
https://www.readbyqxmd.com/read/27832265/prevalence-of-semicircular-canal-hypoplasia-in-patients-with-charge-syndrome-3c-syndrome
#14
Andre Wineland, Maithilee D Menezes, Joshua S Shimony, Marwan S Shinawi, Timothy E Hullar, Keiko Hirose
Importance: CHARGE syndrome refers to a syndrome involving coloboma, heart defects, atresia choanae, retardation of growth and development, genitourinary disorders, and ear anomalies. However, Verloes revised the characteristics of CHARGE syndrome in 2005 to define this syndrome more broadly. Deficiency of the semicircular canals is now a major criterion for CHARGE syndrome. Objective: To characterize patients with CHARGE syndrome at our center using Verloes' criteria and to reevaluate the nomenclature for this condition...
November 10, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27821435/what-can-be-learned-from-recent-new-drug-applications-a-systematic-review-of-drug-interaction-data-for-drugs-approved-by-the-u-s-fda-in-2015
#15
Jingjing Yu, Zhu Zhou, Katie H Owens, Tasha K Ritchie, Isabelle Ragueneau-Majlessi
As a follow-up to previous reviews, the aim of the present analysis was to systematically examine all drug metabolism, transport, PK, and DDI data available in the 33 NDAs and 12 BLAs approved by the FDA in 2015, using the University of Washington Drug Interaction Database©, and to highlight the significant findings. All of the NDAs were well-characterized with regard to drug metabolism, transport, and/or organ impairment, and were fully analyzed in this review. In vitro, a majority of the NMEs were found to be substrates or inhibitors/inducers of at least one DME or transporter...
November 7, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27817865/mecr-mutations-cause-childhood-onset-dystonia-and-optic-atrophy-a-mitochondrial-fatty-acid-synthesis-disorder
#16
Gali Heimer, Juha M Kerätär, Lisa G Riley, Shanti Balasubramaniam, Eran Eyal, Laura P Pietikäinen, J Kalervo Hiltunen, Dina Marek-Yagel, Jeffrey Hamada, Allison Gregory, Caleb Rogers, Penelope Hogarth, Martha A Nance, Nechama Shalva, Alvit Veber, Michal Tzadok, Andreea Nissenkorn, Davide Tonduti, Florence Renaldo, Ichraf Kraoua, Celeste Panteghini, Lorella Valletta, Barbara Garavaglia, Mark J Cowley, Velimir Gayevskiy, Tony Roscioli, Jonathon M Silberstein, Chen Hoffmann, Annick Raas-Rothschild, Valeria Tiranti, Yair Anikster, John Christodoulou, Alexander J Kastaniotis, Bruria Ben-Zeev, Susan J Hayflick
Mitochondrial fatty acid synthesis (mtFAS) is an evolutionarily conserved pathway essential for the function of the respiratory chain and several mitochondrial enzyme complexes. We report here a unique neurometabolic human disorder caused by defective mtFAS. Seven individuals from five unrelated families presented with childhood-onset dystonia, optic atrophy, and basal ganglia signal abnormalities on MRI. All affected individuals were found to harbor recessive mutations in MECR encoding the mitochondrial trans-2-enoyl-coenzyme A-reductase involved in human mtFAS...
November 1, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27814882/commentary-on-the-oestrogen-receptor-alpha-regulated-lncrna-neat1-is-a-critical-modulator-of-prostate-cancer-chakravarty-d-sboner-a-nair-ss-giannopoulou-e-li-r-hennig-s-mosquera-jm-pauwels-j-park-k-kossai-m-macdonald-ty-fontugne-j-erho-n-vergara-ia-ghadessi
#18
https://www.readbyqxmd.com/read/27814881/commentary-on-tracking-the-origins-and-drivers-of-subclonal-metastatic-expansion-in-prostate-cancer-hong-mk-macintyre-g-wedge-dc-van-loo-p-patel-k-lunke-s-alexandrov-lb-sloggett-c-cmero-m-marass-f-tsui-d-mangiola-s-lonie-a-naeem-h-sapre-n-phal-pm-kurganovs
#19
https://www.readbyqxmd.com/read/27814880/commentary-on-rna-biomarkers-associated-with-metastatic-progression-in-prostate-cancer-a-multi-institutional-high-throughput-analysis-of-schlap1-prensner-jr-zhao-s-erho-n-schipper-m-iyer-mk-dhanasekaran-sm-magi-galluzzi-c-mehra-r-sahu-a-siddiqui-j-davicioni
#20
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