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JOURNAL ARTICLE
Sze May Ng, Neil P Wright, Diana Yardley, Fiona Campbell, Tabitha Randell, Nicola Trevelyan, Atrayee Ghatak, Peter C Hindmarsh
Hybrid closed-loop (HCL) systems seamlessly interface continuous glucose monitoring (CGM) with insulin pumps, employing specialised algorithms and user-initiated automated insulin delivery. This study aimed to assess the efficacy of HCLs at 12 months post-initiation on glycated haemoglobin (HbA1c), time-in-range (TIR), hypoglycaemia frequency, and quality of life measures among children and young people (CYP) with type 1 diabetes mellitus (T1DM) and their caregivers in a real-world setting. Conducted between August 1, 2021, and December 10, 2022, the prospective recruitment took place in eight paediatric diabetes centres across England under the National Health Service England's (NHSE) HCL pilot real-world study...
April 24, 2024: BMC Medicine
#22
JOURNAL ARTICLE
Abel A Pavía-López, José A Magaña-Serrano, José A Cigarroa-López, Adolfo Chávez-Mendoza, José L Mayorga-Butrón, Diego Araiza-Garaygordobil, Juan B Ivey-Miranda, Gustavo F Méndez-Machado, Héctor González-Godínez, Luisa F Aguilera-Mora, Antonio Jordán-Ríos, Luis Olmos-Domínguez, Marcos J Olalde-Román, Emma M Miranda-Malpica, Zuilma Vázquez-Ortiz, Jorge Rayo-Chávez, Alexandra A Mendoza, Manlio F Márquez-Murillo, Sergio A Chávez-Leal, Amada Álvarez-San Gabriel, Marissa A Silva-García, Alex D Pacheco-Bouthiller, Jorge A Aldrete-Velazco, Carlos A Guizar-Sánchez, Efraín Gaxiola-López, Arturo Guerra-López, Lourdes Figueiras-Graillet, Gustavo Sánchez-Miranda, Genaro H Mendoza-Zavala, Moisés Aceves-García, Adolfo Chávez-Negrete, Marisol Arroyo-Hernández, Bertha B Montaño-Velázquez, Luis F Romero-Moreno, María M Baquero-Hoyos, Liliana Velasco-Hidalgo, Ana L Rodríguez-Lozano, Nancy E Aguilar-Gómez, Mario Rodríguez-Vega, Jorge E Cossío-Aranda
Chronic heart failure continues to be one of the main causes of impairment in the functioning and quality of life of people who suffer from it, as well as one of the main causes of mortality in our country and around the world. Mexico has a high prevalence of risk factors for developing heart failure, such as high blood pressure, diabetes, and obesity, which makes it essential to have an evidence-based document that provides recommendations to health professionals involved in the diagnosis and treatment of these patients...
2024: Archivos de Cardiología de México
#23
JOURNAL ARTICLE
Emanuel A Keiler, Kim M Kerr, David S Poch, Jenny Z Yang, Demosthenes G Papamatheakis, Mona Alotaibi, Angela Bautista, Victor G Pretorius, Michael M Madani, Nick H Kim, Timothy M Fernandes
Current predictors of clinical outcomes after pulmonary thromboendarterectomy (PTE) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) are largely limited to preoperative clinical characteristics. N-terminal-pro-brain natriuretic peptide (NT-pro-BNP), a biomarker of right ventricular dysfunction, has not yet been well described as one such predictor. From 2017 to 2021, 816 patients with CTEPH referred to the University of California, San Diego for PTE were reviewed for differences in NT-pro-BNP to predict preoperative characteristics and postoperative outcomes up to 30 days post-PTE...
April 2024: Pulmonary Circulation
#24
JOURNAL ARTICLE
Annie Sylvea Valan, Jogikalmat Krithikadatta, Ajay Guru
Objectives Root canal treatments aim to eliminate biofilms effectively. Considering the limitations of chemical irrigants, there is growing interest in natural alternatives like periostracum due to their antibacterial and fouling-resistant properties. This study aimed to assess periostracum's toxicity as a root canal irrigant by investigating its effects on zebrafish embryos' heart rate, survival rate, and hatching rate, as well as inflammation studies using neutral red assays comparing it to standard irrigants like ethylenediaminetetraacetic acid (EDTA), chlorhexidine (CHX), and sodium hypochlorite (NaOCl)...
March 2024: Curēus
#25
Natali Sorajja, Joon Chung, Carmela Alcántara, Sylvia Wassertheil-Smoller, Frank J Penedo, Alberto R Ramos, Krista M Perreira, Martha L Daviglus, Shakira F Suglia, Linda C Gallo, Peter Y Liu, Susan Redline, Carmen R Isasi, Tamar Sofer
BACKGROUND: Sex differences are related to both biological factors and the gendered environment. To untangle sex-related effects on health and disease it is important to model sex-related differences better. METHODS: Data came from the baseline visit of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a longitudinal cohort study following 16,415 individuals recruited at baseline from four study sites: Bronx NY, Miami FL, San Diego CA, and Chicago IL...
April 10, 2024: medRxiv
#26
JOURNAL ARTICLE
Alhelí Calderón-Villarreal, Lourdes Johanna Avelar Portillo, Daniela Abramovitz, Shira Goldenberg, Shawn Flanigan, Penelope J E Quintana, Alicia Harvey-Vera, Carlos F Vera, Gudelia Rangel, Steffanie A Strathdee, Georgia L Kayser
BACKGROUND: Water, sanitation, and hygiene (WASH) access is critical to public health and human dignity. People who inject drugs (PWID) experience stigma and structural violence that may limit WASH access. Few studies have assessed WASH access, insecurity, and inequities among PWID. We describe WASH access, social and geographic inequalities, and factors associated with WASH insecurity among PWID in the Tijuana-San Diego metropolitan area. METHODS: In this cross-sectional binational study, we interviewed PWID (age 18+) in 2020-2021 about WASH access and insecurity...
April 22, 2024: International Journal for Equity in Health
#27
JOURNAL ARTICLE
Jeffrey J Swigris, Kerri Aronson, Evans R Fernández Pérez
BACKGROUND: Dyspnea impairs quality of life (QOL) in patients with fibrotic hypersensitivity pneumonitis (FHP). The Living with Pulmonary Fibrosis questionnaire (L-PF) assesses symptoms, their impacts and PF-related QOL in patients with any form of PF. Its scores have not undergone validation analyses in an FHP cohort. METHODS: We used data from the Pirfenidone in FHP trial to examine reliability, validity and responsiveness of the L-PF-35 Dyspnea domain score (Dyspnea) and to estimate its meaningful within-patient change (MWPC) threshold for worsening...
April 19, 2024: BMC Pulmonary Medicine
#28
JOURNAL ARTICLE
Jorge Vicente-Guijarro, Diego San Jose-Saras, Jesús María Aranaz-Andres
No abstract text is available yet for this article.
April 17, 2024: Medicina Clínica
#29
JOURNAL ARTICLE
Christa A Arefieva, Kelly DiLorenzo, Christanne H Coffey
INTRODUCTION: Current literature on stingray envenomations focuses on the incidence, presentation, and complications of these injuries, with some studies providing such data for specific geographic locations. This is the first study to evaluate the influence of environmental factors and human characteristics on stingray envenomation patterns in San Diego, California. METHODS: Incident reports of injuries documented by the San Diego Fire-Rescue Department/Lifeguard Division (SDFR-LG) during 2017 were analyzed...
April 15, 2024: Wilderness & Environmental Medicine
#30
JOURNAL ARTICLE
Davide Seminati, Vincenzo L'Imperio, Gabriele Casati, Joranda Ceku, Daniela Pilla, Carla Rossana Scalia, Gianluca Gragnano, Francesco Pepe, Pasquale Pisapia, Luca Sala, Diego Luigi Cortinovis, Francesca Bono, Umberto Malapelle, Giancarlo Troncone, Silvia Novello, Fabio Pagni
BACKGROUND: The molecular diagnostic and therapeutic pathway of Non-Small Cell Lung Cancer (NSCLC) stands as a successful example of precision medicine. The scarcity of material and the increasing number of biomarkers to be tested have prompted the routine application of next-generation-sequencing (NGS) techniques. Despite its undeniable advantages, NGS involves high costs that may impede its broad adoption in laboratories. This study aims to assess the detailed costs linked to the integration of NGS diagnostics in NSCLC to comprehend their financial impact...
April 15, 2024: Heliyon
#31
JOURNAL ARTICLE
Haiyan Zhang, Xiazhu Su, Xiangkuan Zheng, Meihan Liu, Chengxin Zhao, Xiao Liu, Zhenxing Ma, Shuang Zhang, Wei Zhang
Pathogenic Escherichia coli strains cause diseases in both humans and animals. The limiting factors to prevent as well as control infections from pathogenic E. coli strains are their pathotypes, serotypes, and drug resistance. Herein, a bacteriophage (vB_EcoM-P896) has been isolated from duck sewage. Furthermore, aside from targeting intestinal pathogenic E. coli strains like enteropathogenic E. coli, Shiga toxin-producing E. coli, entero-invasive E. coli, and enteroaggregative E. coli, vB_EcoM-P896 can cause lysis in extraintestinal pathogenic E...
April 13, 2024: International Microbiology: the Official Journal of the Spanish Society for Microbiology
#32
JOURNAL ARTICLE
Kelsey M Woldt, R Brandon Pratt, Mark J Statham, Laureen M Barthman-Thompson, Diego Sustaita
The salt marsh harvest mouse (Reithrodontomys raviventris) is an endangered species, endemic to the San Francisco Bay Estuary, that co-occurs with the more broadly distributed species, the western harvest mouse (Reithrodontomys megalotis). Despite their considerable external morphological similarities, the northern subspecies of salt marsh harvest mice have relatively longer and thicker tails than do western harvest mice, which may be related to their abilities to climb emergent marsh vegetation to avoid tidal inundation...
April 13, 2024: Journal of Anatomy
#33
REVIEW
Ana M Celorrio San Miguel, Enrique Roche, María Herranz-López, Marta Celorrio San Miguel, Juan Mielgo-Ayuso, Diego Fernández-Lázaro
Melatonin (N-acetyl-5 methoxytryptamine) is an indolic neurohormone that modulates a variety of physiological functions due to its antioxidant, anti-inflammatory, and immunoregulatory properties. Therefore, the purpose of this study was to critically review the effects of melatonin supplementation in sports performance and circulating biomarkers related to the health status of highly trained athletes. Data were obtained by performing searches in the following three bibliography databases: Web of Science, PubMed, and Scopus...
March 30, 2024: Nutrients
#34
JOURNAL ARTICLE
James F Holmes, Kenneth Yen, Irma T Ugalde, Paul Ishimine, Pradip P Chaudhari, Nisa Atigapramoj, Mohamed Badawy, Kevan A McCarten-Gibbs, Donovan Nielsen, Allyson C Sage, Grant Tatro, Jeffrey S Upperman, P David Adelson, Daniel J Tancredi, Nathan Kuppermann
BACKGROUND: The intra-abdominal injury and traumatic brain injury prediction rules derived by the Pediatric Emergency Care Applied Research Network (PECARN) were designed to reduce inappropriate use of CT in children with abdominal and head trauma, respectively. We aimed to validate these prediction rules for children presenting to emergency departments with blunt abdominal or minor head trauma. METHODS: For this prospective validation study, we enrolled children and adolescents younger than 18 years presenting to six emergency departments in Sacramento (CA), Dallas (TX), Houston (TX), San Diego (CA), Los Angeles (CA), and Oakland (CA), USA between Dec 27, 2016, and Sept 1, 2021...
May 2024: Lancet Child & Adolescent Health
#35
JOURNAL ARTICLE
Jessica J Zakrzewski, Neal Doran, Tina L Mayes, Elizabeth W Twamley, Catherine R Ayers
Hoarding Disorder (HD) is a prominent and disabling neuropsychiatric condition defined by the inability to discard objects resulting in impairing levels of clutter. The prevalence rate is 2-6 % and increases with age. The aging Veteran population is a high risk group for impairment associated with HD. Medical and psychiatric comorbidities as well as associated rates of disability and poor quality of life are very common in both HD and the related disorder of OCD. We examined rates of HD and OCD diagnoses at the VA San Diego Healthcare System...
April 6, 2024: Psychiatry Research
#36
JOURNAL ARTICLE
Lu Zhang, Lifeng Shi, Ruijie Zhang, Xinao Lin, Yunlei Bao, Feng Jiang, Chuyan Wu, Jimei Wang
BACKGROUND: Kawasaki disease is a systemic vascular disease with an unclear pathophysiology that primarily affects children under the age of five. Research on immune control in Kawasaki disease has been gaining attention. This study aims to apply a bibliometric analysis to examine the present and future directions of immune control in Kawasaki disease. METHODS: By utilizing the themes "Kawasaki disease," "Kawasaki syndrome," and "immune control," the Web of Science Core Collection database was searched for publications on immune control in Kawasaki disease...
April 11, 2024: Cardiology in the Young
#37
JOURNAL ARTICLE
Siuly Siuly, Smith K Khare, Enamul Kabir, Muhammad Tariq Sadiq, Hua Wang
Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting the quality of life of over 10 million individuals worldwide. Early diagnosis is crucial for timely intervention and better patient outcomes. Electroencephalogram (EEG) signals are commonly used for early PD diagnosis due to their potential in monitoring disease progression. But traditional EEG-based methods lack exploration of brain regions that provide essential information about PD, and their performance falls short for real-time applications...
April 9, 2024: Computers in Biology and Medicine
#38
JOURNAL ARTICLE
Wei Tang, ChengLing Zhang, Dongjing Yang, Jukui Ma, Jingwei Chen, Fangyuan Gao, Yiping Xie, Houjun Sun
Sweet potato (Ipomoea batatas [L.] Lam.) is a versatile crop, cultivated in the subtropical and tropical areas, as food, fodder, and industrial raw material crop. In China, sweet potato has been used as a health-care food in recent years, as it contains a wide range of nutrients and xenobiotic phytochemicals. However, viral diseases are major constraint for the sweet potato yield and quality, especially the seed production and quality. Over 30 species of viruses infect sweet potato worldwide (Clark et al. 2012)...
April 10, 2024: Plant Disease
#39
JOURNAL ARTICLE
Rebecca Ryznar, Anthony LaPorta, Spencer Cooper, Nicholas Maher, Christian Clodfelder, Jeffrey Edwards, Francina Towne, K Dean Gubler
OBJECTIVE: The objective of this study was to investigate possible immune cytokine trends throughout a week-long surgical simulation mass-casualty training session in order to determine the effects of stress inoculation on the immune system. METHODS: Thirty-seven military medical students participated in a hyper-realistic surgical simulation training event conducted at Strategic Operations site in San Diego, California. Salivary samples were collected every morning of the stress training exercise for 4 consecutive days...
January 2024: American Journal of Disaster Medicine
#40
JOURNAL ARTICLE
Lauryn C Gabby, Chelsea K Jones, Brendan B McIntyre, Zoe Manalo, Morgan Meads, Donald P Pizzo, Jessica Diaz-Vigil, Francesca Soncin, Kathleen M Fisch, Gladys A Ramos, Marni B Jacobs, Mana M Parast
BACKGROUND: SARS-CoV-2 infection during pregnancy is associated with increased risk of stillbirth, preeclampsia and preterm birth. However, this does not appear to be due to intrauterine fetal infection, as vertical transmission is rarely reported. There is a paucity of data regarding associated placental SARS-CoV-2 histopathology and their relationship to timing and severity of infection. OBJECTIVE: To determine if maternal SARS-CoV-2 infection is associated with specific patterns of placental injury and whether these findings differ by gestational age at time of infection or disease severity...
April 3, 2024: American Journal of Obstetrics and Gynecology
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