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Shuangbo liu

Liyong Zhang, David J Tester, Di Lang, Yili Chen, Jinxiang Zheng, Rui Gao, Robert F Corliss, Shuangbo Tang, John W Kyle, Chao Liu, Michael J Ackerman, Jonathan C Makielski, Jianding Cheng
OBJECTIVE: To look for previously unrecognized cardiac structural abnormalities and address the genetic cause for sudden unexplained nocturnal death syndrome (SUNDS). METHODS: Data for 148 SUNDS victims and 444 controls (matched 1:3 on sex, race, and age of death within 1 year) were collected from Sun Yat-sen University from January 1, 1998, to December 31, 2014, to search morphological changes. An additional 17 patients with Brugada syndrome (BrS) collected from January 1, 2006, to December 31, 2014, served as a comparative disease cohort...
October 1, 2016: Mayo Clinic Proceedings
Qianhao Zhao, Yili Chen, Longlun Peng, Rui Gao, Nian Liu, Pingping Jiang, Chao Liu, Shuangbo Tang, Li Quan, Jonathan C Makielski, Jianding Cheng
Sudden unexplained nocturnal death syndrome (SUNDS) is a perplexing disorder to both forensic pathologists and clinic physicians. Desmoplakin (DSP) gene was the first desmosomal gene linked to arrhythmogenic right ventricular cardiomyopathy (ARVC) which was associated with sudden death. To identify the genetic variants of the DSP gene in SUNDS in the southern Chinese Han population, we genetically screened the DSP gene in 40 sporadic SUNDS victims, 16 Brugada syndrome (BrS) patients, and 2 early repolarization syndrome (ERS) patients using next generation sequencing (NSG) and direct Sanger sequencing...
March 2016: International Journal of Legal Medicine
Shuangbo Liu, Motaz Moussa, Anthony W Wassef, Brett M Hiebert, Farrukh Hussain, Davinder S Jassal
BACKGROUND: Early identification of high-grade ischemia based on echocardiographic diastolic abnormalities may be clinically useful in the acute coronary syndrome (ACS) setting. This could provide the clinician with an awareness of the burden of coronary artery disease (CAD) before angiography is performed to allow for early intervention of suspected ischemic lesions. The objective of the study was to assess whether 2D transthoracic echocardiography (TTE)-derived tissue Doppler imaging parameters can predict the severity of CAD in comparison with the cardiac catheterization-derived SYNTAX score...
January 2016: Echocardiography
Hui He, Shuangbo Kong, Fei Liu, Shuang Zhang, Yaling Jiang, Yixin Liao, Yufei Jiang, Qian Li, Bingyan Wang, Zuomin Zhou, Haibin Wang, Ran Huo
Uterine stromal cells undergo extensive proliferation and differentiation during postimplantation development, a process known as decidualization. While a range of signaling molecules have been demonstrated to play essential roles in this event, its potential epigenetic regulatory mechanisms remain largely unknown. Retinoblastoma binding protein 7 (Rbbp7) is a protein reported as a core component of many histone modification and chromatin remodeling complexes. In the present study, our in situ hybridization and immunochemistry analysis first reveals a spatiotemporal expression of Rbbp7 in the uterus during the peri-implantation period...
July 2015: Biology of Reproduction
Jinxiang Zheng, Erwen Huang, Shuangbo Tang, Qiuping Wu, Lei Huang, Dongchuan Zhang, Li Quan, Chao Liu, Jianding Cheng
To study the epidemiological characteristics of sudden unexplained nocturnal death syndrome (SUNDS) in the southern Chinese Han population during 2007 to 2013, we gathered 879 SUNDS victims from Dongguan City and in the Longgang District in Shenzhen City as the case group then selected 879 all-cause death cases, adopting a 1:1 pair method, as the control group I and collected 8142 all-cause death cases from the Bao'an District in Shenzhen City as the control group II, simultaneously. Case information collected was statistically analyzed...
March 2015: American Journal of Forensic Medicine and Pathology
Shuangbo Liu, Tamara Glavinovic, James W Tam
Left ventricular free wall rupture is a catastrophic mechanical complication of myocardial infarction. We present an 82-year-old woman with an anterolateral ST segment elevation myocardial infarction treated with thrombolysis. Because of unexplained hypotension, echocardiography was performed and contrast (Definity; Lantheus Medical Imaging) was used to improve visualization. Findings included a small- to moderate-sized circumferential pericardial effusion without frank tamponade, however, there was significant intramyocardial tracking of the contrast into the epicardial space, localized to the mid to apical portion of the anterior septum, consistent with rupture or disruption of the wall segment...
January 2015: Canadian Journal of Cardiology
Carmen Hrymak, Shuangbo Liu, Joshua Koulack, Duane J Funk, S Allan Schaffer, James W Tam
A 59-year-old woman with stroke and thromboembolic aortoiliac disease in the setting of profound stress was found to have severe left ventricular (LV) systolic dysfunction and large mobile clot on focused cardiac ultrasonography (FCU). Marked recovery of LV function and thrombus resolution within 4 days suggested resolving Takotsubo cardiomyopathy. The role of FCU in early diagnosis and treatment is outlined here.
December 2014: Canadian Journal of Cardiology
Shuangbo Liu, David Horne, Darren H Freed, Siuchan Sookhoo, Jacek Strzelczyk, Amir Ravandi, Davinder S Jassal
No abstract text is available yet for this article.
June 17, 2014: Journal of the American College of Cardiology
Lei Huang, Chao Liu, Shuangbo Tang, Terry Su, Jianding Cheng
To investigate the genetic variants of the RyR2 gene in sudden unexplained nocturnal death syndrome (SUNDS) in the southern Chinese Han population, we genetically screened 29 of the 105 coding exons of the RyR2 gene associated with catecholaminergic polymorphic ventricular tachycardia (CPVT) and arrhythmogenic right ventricular cardiomyopathy (ARVC) in sporadic SUNDS victims using polymerase chain reaction (PCR) and direct sequencing methods. Genomic DNA was extracted from blood samples of 127 SUNDS cases and 165 healthy unrelated controls...
February 2014: Forensic Science International
Chao Liu, Qianhao Zhao, Terry Su, Shuangbo Tang, Guoli Lv, Hong Liu, Li Quan, Jianding Cheng
The etiology of sudden unexplained nocturnal death syndrome (SUNDS) remains unclear. Previous studies have implicated that SUNDS is probably allelic to cardiac sodium channel diseases such as Brugada syndrome. The variation in cardiac potassium channels is the main genetic cause of inherited long QT syndrome (LQTS), which may manifest as syncope and sudden cardiac death without structural disease. We hypothesized that cardiac potassium channel disease may be responsible for certain Chinese SUNDS cases. Genotyping of 4 main LQTS-susceptibility genes (KCNQ1, KCNH2, KCNE1, and KCNE2) was performed here for the first time in SUNDS victims from the Chinese Han population to address the pathogenic cause of some SUNDS using polymerase chain reaction and direct DNA sequencing...
September 10, 2013: Forensic Science International
Surinder Dhaliwal, Robin Ducas, Liu Shuangbo, David Horne, John Lee, Farrukh Hussain, Iain D C Kirkpatrick, Davinder S Jassal
BACKGROUND: Ventricular septal rupture (VSR), a mechanical complication following an acute myocardial infarction (MI), is thought to result from coagulation necrosis due to lack of collateral reperfusion. Although the gold standard test to confirm left-to-right shunting between ventricular cavities remains invasive ventriculography, two-dimensional transthoracic echocardiography (TTE) with color flow Doppler and cardiac MRI (CMR) are reliable tests for the non-invasive diagnosis of VSR...
2012: BMC Research Notes
Joy Armistead, Sunita Khatkar, Britta Meyer, Brian L Mark, Nehal Patel, Gail Coghlan, Ryan E Lamont, Shuangbo Liu, Jill Wiechert, Peter A Cattini, Peter Koetter, Klaus Wrogemann, Cheryl R Greenberg, Karl-Dieter Entian, Teresa Zelinski, Barbara Triggs-Raine
Bowen-Conradi syndrome (BCS) is an autosomal-recessive disorder characterized by severely impaired prenatal and postnatal growth, profound psychomotor retardation, and death in early childhood. Nearly all reported BCS cases have been among Hutterites, with an estimated birth prevalence of 1/355. We previously localized the BCS gene to a 1.9 Mbp interval on human chromosome 12p13.3. The 59 genes in this interval were ranked as candidates for BCS, and 35 of these, including all of the best candidates, were sequenced...
June 2009: American Journal of Human Genetics
Chongyun Wang, Wenyao Liu, Lunhui Liu, Jianwu Cui
Plant diversity of different replaced communities after Eupatorium adenophorum removal. WANG In this paper, an investigation on the structure, species composition and plant diversity of replaced communities after the removal of invasive E. adenophorum at the beginning of 1980s was made in the Shuangbo County of Yunnan Province, with local aged Pinus yunnanensis and unmanaged E. adenophorum forests as the reference. The results showed that in replaced communities, the richness, Shannon-Wiener, Simpson, and Pielou evenness indices values of woody species were 25 to approximately 28, 1...
March 2006: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
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