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https://www.readbyqxmd.com/read/28444198/isolation-of-the-lyme-disease-spirochete-borrelia-mayonii-from-naturally-infected-rodents-in-minnesota
#1
Tammi L Johnson, Christine B Graham, Andrias Hojgaard, Nicole E Breuner, Sarah E Maes, Karen A Boegler, Adam J Replogle, Luke C Kingry, Jeannine M Petersen, Lars Eisen, Rebecca J Eisen
Borrelia mayonii is a newly described member of the Borrelia burgdorferi sensu lato complex that is vectored by the black-legged tick (Ixodes scapularis Say) and a cause of Lyme disease in Minnesota and Wisconsin. Vertebrate reservoir hosts involved in the enzootic maintenance of B. mayonii have not yet been identified. Here, we describe the first isolation of B. mayonii from naturally infected white-footed mice (Peromyscus leucopus Rafinesque) and an American red squirrel (Tamiasciurus hudsonicus Erxleben) from Minnesota, thus implicating these species as potential reservoir hosts for this newly described spirochete...
April 24, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28443079/pleomorphism-and-viability-of-the-lyme-disease-pathogen-borrelia-burgdorferi-exposed-to-physiological-stress-conditions-a-correlative-cryo-fluorescence-and-cryo-scanning-electron-microscopy-study
#2
Marie Vancová, Nataliia Rudenko, Jiří Vaněček, Maryna Golovchenko, Martin Strnad, Ryan O M Rego, Lucie Tichá, Libor Grubhoffer, Jana Nebesářová
To understand the response of the Lyme disease spirochete Borrelia burgdorferi exposed to stress conditions and assess the viability of this spirochete, we used a correlative cryo-fluorescence and cryo-scanning microscopy approach. This approach enables simple exposition of bacteria to various experimental conditions that can be stopped at certain time intervals by cryo-immobilization, examination of cell viability without necessity to maintain suitable culture conditions during viability assays, and visualization of structures in their native state at high magnification...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28440258/neuroretinitis-as-presenting-and-the-only-presentation-of-lyme-disease-diagnosis-and-management
#3
Brahm Prakash Guliani, Sandeep Kumar, Neha Chawla, Anuj Mehta
We present a case of neuroretinitis as presenting and the only presentation of Lyme disease in a 25-year-old female who visited hilly areas in the Himalayas of North India. She presented with right eye sudden and painless blurring of vision. Her vision at presentation was 20/60. She had fundus examination; fundus fluorescein angiography (FFA) and optical coherence tomography (OCT) imaging showed classical features of neuroretinitis. No other organ was involved. Oral steroids were prescribed and relevant investigations sent for noninfective and infective causes...
March 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28438912/effects-of-conservation-management-of-landscapes-and-vertebrate-communities-on-lyme-borreliosis-risk-in-the-united-kingdom
#4
REVIEW
Caroline Millins, Lucy Gilbert, Jolyon Medlock, Kayleigh Hansford, Des Ba Thompson, Roman Biek
Landscape change and altered host abundance are major drivers of zoonotic pathogen emergence. Conservation and biodiversity management of landscapes and vertebrate communities can have secondary effects on vector-borne pathogen transmission that are important to assess. Here we review the potential implications of these activities on the risk of Lyme borreliosis in the United Kingdom. Conservation management activities include woodland expansion, management and restoration, deer management, urban greening and the release and culling of non-native species...
June 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28438910/lyme-disease-ecology-in-a-changing-world-consensus-uncertainty-and-critical-gaps-for-improving-control
#5
REVIEW
A Marm Kilpatrick, Andrew D M Dobson, Taal Levi, Daniel J Salkeld, Andrea Swei, Howard S Ginsberg, Anne Kjemtrup, Kerry A Padgett, Per M Jensen, Durland Fish, Nick H Ogden, Maria A Diuk-Wasser
Lyme disease is the most common tick-borne disease in temperate regions of North America, Europe and Asia, and the number of reported cases has increased in many regions as landscapes have been altered. Although there has been extensive work on the ecology and epidemiology of this disease in both Europe and North America, substantial uncertainty exists about fundamental aspects that determine spatial and temporal variation in both disease risk and human incidence, which hamper effective and efficient prevention and control...
June 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28435891/detection-of-anaplasma-phagocytophilum-babesia-microti-borrelia-burgdorferi-borrelia-miyamotoi-and-powassan-virus-in-ticks-by-a-multiplex-real-time-reverse-transcription-pcr-assay
#6
Rafal Tokarz, Teresa Tagliafierro, D Moses Cucura, Ilia Rochlin, Stephen Sameroff, W Ian Lipkin
Ixodes scapularis ticks are implicated in transmission of Anaplasma phagocytophilum, Borrelia burgdorferi, Borrelia miyamotoi, Babesia microti, and Powassan virus. We describe the establishment and implementation of the first multiplex real-time PCR assay with the capability to simultaneously detect and differentiate all five pathogens in a single reaction. The application of this assay for analysis of ticks at sites in New York and Connecticut revealed a high prevalence of B. microti in ticks from Suffolk County, NY...
March 2017: MSphere
https://www.readbyqxmd.com/read/28435311/application-of-bayesian-decision-making-to-laboratory-testing-for-lyme-disease-and-comparison-with-testing-for-hiv
#7
Michael J Cook, Basant K Puri
In this study, Bayes' theorem was used to determine the probability of a patient having Lyme disease (LD), given a positive test result obtained using commercial test kits in clinically diagnosed patients. In addition, an algorithm was developed to extend the theorem to the two-tier test methodology. Using a disease prevalence of 5%-75% in samples sent for testing by clinicians, evaluated with a C6 peptide enzyme-linked immunosorbent assay (ELISA), the probability of infection given a positive test ranged from 26...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/28432738/tick-bite-and-lyme-disease-related-emergency-department-encounters-in-new-hampshire-2010-2014
#8
E R Daly, C Fredette, A A Mathewson, K Dufault, D J Swenson, B P Chan
Lyme disease (LD) is a common tick-borne disease in New Hampshire (NH). While LD is a reportable condition and cases are counted for public health surveillance, many more people receive care for tick bites or diagnoses of LD than are reflected in surveillance data. NH's emergency department (ED) data system was queried for tick bite and LD-related encounters. Chief complaint text was queried for words related to LD or tick bites. International Classification of Diseases 9th Revision (ICD-9) codes were queried for the LD diagnosis code (088...
April 22, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28425901/a-systematic-review-and-meta-analysis-for-the-adverse-effects-immunogenicity-and-efficacy-of-lyme-disease-vaccines-guiding-novel-vaccine-development
#9
Alaa Badawi, Maria Shering, Shusmita Rahman, L Robbin Lindsay
BACKGROUND: Lyme borreliosis (LB) is the most prevalent arthropod-borne infectious disease in North America. Currently, no vaccine is available to prevent LB in humans, although monovalent and multivalent vaccines have been developed in the past. OBJECTIVE: The aim of the current study is to conduct a systematic review and meta-analysis to evaluate and compare the findings from these two classes of vaccines for their reactogenicity, immunogenicity and efficacy, in the hope this may assist in the development of future vaccines...
April 20, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28416425/-bilateral-facial-nerve-palsy-associated-with-epstein-barr-virus-infection-in-a-3-year-old-boy
#10
M Grassin, A Rolland, N Leboucq, A Roubertie, F Rivier, P Meyer
Bilateral facial nerve palsy is a rare and sometimes difficult diagnosis. We describe a case of bilateral simultaneous facial nerve palsy associated with Epstein-Barr virus (EBV) infection in a 3-year-old boy. Several symptoms led to the diagnosis of EBV infection: the clinical situation (fever, stomachache, and throat infection), white blood cell count (5300/mm(3) with 70% lymphocyte count), seroconversion with EBV-specific antibodies, lymphocytic meningitis, and a positive blood EBV polymerase chain reaction (9...
April 14, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28412525/liver-microbiome-of-peromyscus-leucopus-a-key-reservoir-host-species-for-emerging-infectious-diseases-in-north-america
#11
A André, A Mouton, V Millien, J Michaux
Microbiome studies generally focus on the gut microbiome, which is composed of a large proportion of commensal bacteria. Here we propose a first analysis of the liver microbiome using next generation sequencing as a tool to detect potentially pathogenic strains. We used Peromyscus leucopus, the main reservoir host species of Lyme disease in eastern North America, as a model and sequenced V5-V6 regions of the 16S gene from 18 populations in southern Quebec (Canada). The Lactobacillus genus was found to dominate the liver microbiome...
April 13, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28409501/successful-treatment-of-fulminant-lyme-myocarditis-with-mechanical-circulatory-support-in-a-young-male-adult-a-case-report
#12
Željko Župan, Dino Mijatović, Igor Medved, Snježana Kraljić, Jurica Juranić, Berislav Barbalić, Marin Oštrić
We describe the case of fulminant myocarditis due to Lyme disease and use of mechanical circulatory support (MCS) for the treatment of the Lyme carditis associated with refractory cardiogenic shock. Fulminant Lyme myocarditis in young adult male patient led to a sudden onset of acute, severe biventricular heart failure with progressive cardiogenic shock, and multiorgan failure immediately after admission.
April 14, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28409041/bilateral-facial-diplegia-a-rare-presenting-symptom-of-lyme
#13
John Ashurst, Matthew Perry
Lyme disease is a common disease that is faced by the physician but also acts a mimicker of many other disease processes. Facial palsies, especially bilateral, are a relatively rare presenting symptom of Lyme disease and may warrant further investigation. A thorough history and physical examination coupled with precision testing may aid the physician when faced with a patient with the diagnostic dilemma of facial diplegia.
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28405553/lyme-disease-a-case-report-with-typical-and-atypical-lesions
#14
Anuj Sharma, Sandesh Guleria, Reena Sharma, Anita Sharma
Lyme disease is a multisystem infectious disease caused by the spirochete "Borrelia burgdorferi," which is transmitted by "Ixodes" tick, with skin being the most common and earliest organ to be affected. Diagnosis of erythema chronicum migrans (ECM), which is the characteristic lesion of early disease, may help in early treatment and prevention of complications. Here, we are reporting a case of Lyme disease in a 10-year-old young boy from a non-endemic zone of Himachal Pradesh, who presented with typical as well as atypical ECM lesions...
March 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28402742/vertebrate-ticks-distribution-and-their-role-as-vectors-in-relation-to-road-edges-and-underpasses
#15
Juan D Delgado, Estefanía Abreu-Yanes, Néstor Abreu-Acosta, Manuel D Flor, Pilar Foronda
Roads fragment vertebrate populations and affect the dynamics and dispersal patterns of vertebrate parasites. We evaluated how vertebrate ticks distribute near roads and road underpasses in human-caused road-fragmented landscapes in Seville, SW Spain. We sampled 49 stations with 93 individualized sampling points and assessed tick abundance. We explored the relationship between tick presence and abundance and distance to the nearest road and underpass (drainage culverts and other passages used by vertebrates), and landscape features through categorical regression and nonparametric statistics...
April 12, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28400357/health-care-professionals-evidence-based-medicine-internet-searches-closely-mimic-the-known-seasonal-variation-of-lyme-borreliosis-a-register-based-study
#16
Samuli Pesälä, Mikko J Virtanen, Jussi Sane, Jukkapekka Jousimaa, Outi Lyytikäinen, Satu Murtopuro, Pekka Mustonen, Minna Kaila, Otto Helve
BACKGROUND: Both health care professionals and nonprofessionals seek medical information on the Internet. Using Web-based search engine searches to detect epidemic diseases has, however, been problematic. Physician's databases (PD) is a chargeable evidence-based medicine (EBM) portal on the Internet for health care professionals and is available throughout the entire health care system in Finland. Lyme borreliosis (LB), a well-defined disease model, shows temporal and regional variation in Finland...
April 11, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28399280/evaluation-of-the-select-tick-control-system-tcs-a-host-targeted-bait-box-to-reduce-exposure-to-ixodes-scapularis-acari-ixodidae-in-a-lyme-disease-endemic-area-of-new-jersey
#17
Terry L Schulze, Robert A Jordan, Martin Williams, Marc C Dolan
We describe a 2-yr trial to evaluate the ability of SELECT Tick Control System (TCS) host-targeted bait boxes to reduce numbers of host-seeking Ixodes scapularis nymphs in a residential neighborhood. After four successive 9-wk deployments, nymphal and larval I. scapularis infestation prevalence and intensity were significantly reduced on target small mammals. In addition, these deployments resulted in 87.9% and 97.3% control of host-seeking nymphs in treatment sites at 1 yr and 2 yr postintervention, respectively...
March 15, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28399276/a-risk-model-for-the-lyme-disease-vector-ixodes-scapularis-acari-ixodidae-in-the-prairie-provinces-of-canada
#18
Vanessa Gabriele-Rivet, Jules K Koffi, Yann Pelcat, Julie Arsenault, Angela Cheng, L Robbin Lindsay, Timothy J Lysyk, Kateryn Rochon, Nicholas H Ogden
Lyme disease is emerging in Canada due to geographic range expansion of the tick vector Ixodes scapularis Say. Recent areas of emergence include parts of the southeastern Canadian Prairie region. We developed a map of potential risk areas for future I. scapularis establishment in the Canadian Prairie Provinces. Six I. scapularis risk algorithms were developed using different formulations of three indices for environmental suitability: temperature using annual cumulative degree-days > 0 °C (DD > 0 °C; obtained from Moderate Resolution Imaging Spectroradiometer satellite data as an index of conditions that allow I...
February 26, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28399208/acquisition-of-borrelia-burgdorferi-infection-by-larval-ixodes-scapularis-acari-ixodidae-associated-with-engorgement-measures
#19
J Couret, M C Dyer, T N Mather, S Han, J I Tsao, R A Lebrun, H S Ginsberg
Measuring rates of acquisition of the Lyme disease pathogen, Borrelia burgdorferi sensu lato Johnson, Schmid, Hyde, Steigerwalt & Brenner, by the larval stage of Ixodes scapularis Say is a useful tool for xenodiagnoses of B. burgdorferi in vertebrate hosts. In the nymphal and adult stages of I. scapularis, the duration of attachment to hosts has been shown to predict both body engorgement during blood feeding and the timing of infection with B. burgdorferi. However, these relationships have not been established for the larval stage of I...
March 18, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28396443/plasma-fibronectin-stabilizes-borrelia-burgdorferi-endothelial-interactions-under-vascular-shear-stress-by-a-catch-bond-mechanism
#20
Alexandra F Niddam, Rhodaba Ebady, Anil Bansal, Anne Koehler, Boris Hinz, Tara J Moriarty
Bacterial dissemination via the cardiovascular system is the most common cause of infection mortality. A key step in dissemination is bacterial interaction with endothelia lining blood vessels, which is physically challenging because of the shear stress generated by blood flow. Association of host cells such as leukocytes and platelets with endothelia under vascular shear stress requires mechanically specialized interaction mechanisms, including force-strengthened catch bonds. However, the biomechanical mechanisms supporting vascular interactions of most bacterial pathogens are undefined...
April 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
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