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https://www.readbyqxmd.com/read/28549151/borrelia-species-detected-in-ticks-feeding-on-wild-korean-water-deer-hydropotes-inermis-using-molecular-and-genotypic-analyses
#1
D VanBik, S H Lee, M G Seo, B R Jeon, Y K Goo, S J Park, M H Rhee, O D Kwon, T H Kim, P J L Geraldino, D Kwak
Lyme borreliosis is a vector-borne disease transmitted through the bite of ticks infected by Borrelia burgdorferi sensu lato group, including B. burgdorferi sensu stricto, B. afzelii, and B. garinii. The goal of the present study was to detect Borrelia species in ticks infesting wild Korean water deer (KWD; Hydropotes inermis Swinhoe), using molecular and genotypic analyses. In total, 48 ticks were collected from KWD, all of which were morphologically identified as Haemaphysalis longicornis Neumann that is dominant in Korea...
May 26, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28545520/the-abundance-of-the-lyme-disease-pathogen-borrelia-afzelii-declines-over-time-in-the-tick-vector-ixodes-ricinus
#2
Maxime Jacquet, Dolores Genné, Alessandro Belli, Elodie Maluenda, Anouk Sarr, Maarten J Voordouw
BACKGROUND: The population dynamics of vector-borne pathogens inside the arthropod vector can have important consequences for vector-to-host transmission. Tick-borne spirochete bacteria of the Borrelia burgdorferi (sensu lato) species complex cause Lyme borreliosis in humans and spend long periods of time (>12 months) in their Ixodes tick vectors. To date, few studies have investigated the dynamics of Borrelia spirochete populations in unfed Ixodes nymphal ticks. METHODS: Larval ticks from our laboratory colony of I...
May 25, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28539197/candidatus-neoehrlichia-mikurensis-and-borrelia-burgdorferi-sensu-lato-detected-in-the-blood-of-norwegian-patients-with-erythema-migrans
#3
H Quarsten, A Grankvist, L Høyvoll, I B Myre, T Skarpaas, V Kjelland, C Wenneras, S Noraas
The most common tick-borne human disease in Norway is Lyme borreliosis. Ticks in Norway also harbour less known disease-causing agents such as Candidatus Neoehrlichia mikurensis, Borrelia miyamotoi and Rickettsia helvetica. However, human infections caused by these pathogens have never been described in Norway. The main aims of the study were to evaluate the contribution of several tick-borne bacterial agents, other than Borrelia burgdorferi sensu lato, to zoonotic diseases in Norway and to determine their clinical pictures...
May 13, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28533930/early-onset-lyme-carditis-with-concurrent-disseminated-erythema-migrans
#4
Kinjan P Patel, Peter D Farjo, Joy J Juskowich, Ali Hama Amin, James D Mills
BACKGROUND: Lyme disease is an infection that is estimated to affect over 300,000 people in the United States annually. Typically, it presents with erythema migrans (EM), an annular rash at the site of tick attachment, within 3 to 30 days of inoculation. Untreated patients may progress to early disseminated disease. A further complication, Lyme carditis is rare but may occur several weeks later. It commonly manifests as a variable atrioventricular (AV) conduction block, with a high-grade AV block occurring in only 1% of untreated patients...
2017: American Journal of Cardiovascular Disease
https://www.readbyqxmd.com/read/28532428/practices-of-lyme-disease-diagnosis-and-treatment-by-general-practitioners-in-quebec-2008-2015
#5
Salima Gasmi, Nicholas H Ogden, Patrick A Leighton, Ariane Adam-Poupart, François Milord, L Robbin Lindsay, Sapha Barkati, Karine Thivierge
BACKGROUND: Lyme disease (LD), a multisystem infection caused by the spirochete Borrelia burgdorferi sensu stricto (B. burgdorferi), is the most reported vector-borne disease in North America, and by 2020, 80% of the population in central and eastern Canada could live in LD risk areas. Among the key factors for minimising the impact of LD are the accurate diagnosis and appropriate management of patients bitten by ticks. In this study, the practices of Quebec general practitioners (GPs) on LD diagnosis and management of patients bitten by infected ticks are described...
May 22, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28528880/lyme-borreliae-prevalence-and-genospecies-distribution-in-ticks-removed-from-humans
#6
Patrick Waindok, Sabine Schicht, Volker Fingerle, Christina Strube
Lyme borreliosis (LB) is the most important human tick-borne disease, but Borrelia genospecies cause different clinical manifestations. Ticks of the genus Ixodes removed from humans between 2006 and 2012 were analysed for Borrelia burgdorferi sensu lato (sl) infections. The majority of ticks originated from the Greater Hanover region in Northern Germany. The engorgement status varied over the entire spectrum from unengorged (no evidence of started blood feeding) to fully engorged. In the present study, prevalence data for B...
May 13, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28526093/canine-infection-with-borrelia-burgdorferi-dirofilaria-immitis-anaplasma-spp-and-ehrlichia-spp-in-canada-2013-2014
#7
Brian H Herrin, Andrew S Peregrine, Jonas Goring, Melissa J Beall, Susan E Little
BACKGROUND: Canine test results generated by veterinarians throughout Canada from 2013-2014 were evaluated to assess the geographical distribution of canine infection with Borrelia burgdorferi, Dirofilaria immitis, Ehrlichia spp., and Anaplasma spp. METHODS: The percent positive test results of 115,636 SNAP® 4Dx® Plus tests from dogs tested were collated by province and municipality to determine the distribution of these vector-borne infections in Canada. RESULTS: A total of 2,844/115,636 (2...
May 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28520981/clinical-presentation-and-outcomes-of-children-with-human-granulocytic-anaplasmosis
#8
Anna M Schotthoefer, Matthew C Hall, Satya Vittala, Raza Bajwa, Holly M Frost
Background.: Adults with the tick-borne disease human granulocytic anaplasmosis (HGA) have a spectrum of acute febrile illnesses that, if untreated, might be severe. Clinical presentation and outcomes of children with HGA have been poorly described. Methods.: A retrospective analysis was conducted to determine the frequency, presentation, and outcomes of pediatric patients with HGA between 1994 and 2015 in a region of Wisconsin in which HGA is highly endemic. Patients with related International Classification of Diseases Ninth and Tenth Revision (ICD-9 and ICD-10, respectively) codes or positive HGA laboratory test results were evaluated and classified as having had confirmed, probable, or suspected HGA on the basis of the Centers for Disease Control and Prevention (CDC) case definition...
May 16, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28518080/rearing-ixodes-scapularis-the-black-legged-tick-feeding-immature-stages-on-mice
#9
Andrew B Nuss, Manoj G Mathew, Monika Gulia-Nuss
Ixodes scapularis, the vector of Lyme disease, is one of the most important disease vectors in the eastern and Midwestern United States. This species is a three host tick that requires a blood meal from a vertebrate host for each development stage, and the adult females require a blood meal for reproduction. Larval ticks attach to their host for 3 - 5 days for feeding and drop off the host when fully engorged. This dependency on several different hosts and the lengthy attachment time for engorgement complicates tick rearing in the laboratory setting...
May 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28518034/relative-risk-for-ehrlichiosis-and-lyme-disease-in-an-area-where-vectors-for-both-are-sympatric-new-jersey-usa
#10
Andrea Egizi, Nina H Fefferman, Robert A Jordan
No abstract text is available yet for this article.
June 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28512589/a-case-of-early-disseminated-neurological-lyme-disease-followed-by-atypical-cutaneous-manifestations
#11
Vamsi Kantamaneni, Vikas Sunder, Mohammad Bilal, Scott Vargo
Lyme disease (LD) is a tick-borne illness caused by Borrelia burgdorferi sensu stricto. An 80-year-old female from Pennsylvania, USA, presented to an outside hospital with fever, confusion, lower extremity weakness, and stool incontinence. CT head and MRI spine were unremarkable. An infectious work-up including lumbar puncture was negative. She was transferred to our tertiary care hospital. Patient was noted to have mild unilateral right-sided facial droop and a diffuse macular rash throughout the body. She denied any outdoor activities, tick bites, or previous rash...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28501998/western-blot-techniques
#12
Brianna Kim
The Western blot is an important laboratory technique that allows for specific identification and characterization of proteins. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE)-separated proteins are electophoretically transferred to a polyvinylidene fluoride (PVDF) membrane which is then incubated with specific antibodies, then developed to show the protein of interest. Here, we describe the transfer and detection of Outer surface protein A (OspA), a protein only found on the surface of Borrelia burgdorferi, the bacteria responsible for Lyme disease...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28488932/powassan-deer-tick-virus-and-borrelia-burgdorferi-infection-in-wisconsin-tick-populations
#13
Konstance K Knox, Angela M Thomm, Yvette A Harrington, Ellen Ketter, Jacob M Patitucci, Donald R Carrigan
Powassan/Deer Tick Virus (POWV/DTV) is an emerging cause of arboviral neuroinvasive disease in the upper Midwest. These studies describe the prevalence and geographic distribution of Wisconsin ticks carrying POWV/DTV as well as the high frequency of Ixodes scapularis ticks coinfected with both POWV/DTV and Borrelia burgdorferi, the causative agent of Lyme disease. These findings suggest that concurrent transmission of POWV/DTV and B. Burgdorferi from coinfected ticks is likely to occur in humans.
May 10, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28487229/every-member-of-the-kingdom-animalia-is-a-potential-vector-of-human-pathogens
#14
LETTER
Seema Patel
Zoonotic diseases are a subset of infectious diseases, which account for enormous morbidity and mortality. Pathologies like malaria, rabies, Lyme disease, leptospirosis, avian flu etc. are microbe- and parasite-caused ailments, where the etiological agents are introduced into or on the human body via ticks, mosquitoes, birds, rodents, bats, and deer, among other members of kingdom Animalia. While some of the zoonotic diseases are well-investigated and caution taken against, a lot many are yet to be recognized...
May 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28484210/identification-of-tp0751-pallilysin-as-a-treponema-pallidum-vascular-adhesin-by-heterologous-expression-in-the-lyme-disease-spirochete
#15
Wei-Chien Andrew Kao, Helena Pětrošová, Rhodaba Ebady, Karen V Lithgow, Pablo Rojas, Yang Zhang, Yae-Eun Kim, Yae-Ram Kim, Tanya Odisho, Nupur Gupta, Annette Moter, Caroline E Cameron, Tara J Moriarty
Treponema pallidum subsp. pallidum, the causative agent of syphilis, is a highly invasive spirochete pathogen that uses the vasculature to disseminate throughout the body. Identification of bacterial factors promoting dissemination is crucial for syphilis vaccine development. An important step in dissemination is bacterial adhesion to blood vessel surfaces, a process mediated by bacterial proteins that can withstand forces imposed on adhesive bonds by blood flow (vascular adhesins). The study of T. pallidum vascular adhesins is hindered by the uncultivable nature of this pathogen...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28484042/a-proteomic-signature-of-dormancy-in-an-actinobacterium-micrococcus-luteus
#16
Sujina Mali, Morgan Mitchell, Spencer Havis, Abiodun Bodunrin, Jonathan Rangel, Gabriella Olson, William R Widger, Steven J Bark
Dormancy is a protective state where diverse bacteria including M. tuberculosis, S. aureus, T. pallidum (syphilis), and B. burgdorferi (Lyme Disease) curtail metabolic activity to survive external stresses including antibiotics. Evidence suggests dormancy consists of a continuum of interrelated states including viable but nonculturable (VBNC) and persistence states. VBNC and persistence contribute to antibiotic tolerance, reemergence from latent infections, and even quorum sensing and biofilm formation. Previous studies indicate that the protein mechanisms regulating persistence and VBNC states are not well understood...
May 8, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28482848/when-a-patient-suspected-with-juvenile-idiopathic-arthritis-turns-out-to-be-diagnosed-with-an-infectious-disease-a-review-of-lyme-arthritis-in-children
#17
REVIEW
Krzysztof Orczyk, Joanna Świdrowska-Jaros, Elżbieta Smolewska
The Lyme arthritis is a common manifestation of infection with Borrelia burgdorferi spirochete. Despite its infectious background, the inflammation clinically and histopatologically resembles juvenile idiopathic arthritis. As it affects a considerable number of Lyme disease patients, it should be routinely considered in differential diagnosis. Development of arthritis is partially dependent on spirochetal factors, including the ribosomal spacer type and the sequence of outer surface protein C. Immunological background involves Th1-related response, but IL-17 provides an additional route of developing arthritis...
May 8, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28480261/geographic-expansion-of-lyme-disease-in-michigan-2000-2014
#18
Paul M Lantos, Jean Tsao, Lise E Nigrovic, Paul G Auwaerter, Vance G Fowler, Felicia Ruffin, Erik Foster, Graham Hickling
BACKGROUND: Most Lyme disease cases in the Midwestern United States are reported in Minnesota and Wisconsin. In recent years, however, a widening geographic extent of Lyme disease has been noted with evidence of expansion eastwards into Michigan and neighboring states with historically low incidence rates. METHODS: We collected confirmed and probable cases of Lyme disease from 2000 through 2014 from the Michigan Department of Health and Human Services, entering them in a geographic information system...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28479174/identification-of-a-defined-linear-epitope-in-the-ospa-protein-of-the-lyme-disease-spirochetes-that-elicits-bactericidal-antibody-responses-implications-for-vaccine-development
#19
Jerilyn R Izac, Lee D Oliver, Christopher G Earnhart, Richard T Marconi
The lipoprotein OspA is produced by the Lyme disease spirochetes primarily in unfed ticks. OspA production is down-regulated by the blood meal and it is not produced in mammals except for possible transient production during late stage infection in patients with Lyme arthritis. Vaccination with OspA elicits antibody (Ab) that can target spirochetes in the tick midgut during feeding and inhibit transmission to mammals. OspA was the primary component of the human LYMErix™ vaccine. LYMErix™ was available from 1998 to 2002 but then pulled from the market due to declining sales as a result of unsubstantiated concerns about vaccination induced adverse events and poor efficacy...
May 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28476293/-usefulness-of-serological-studies-for-the-early-diagnosis-of-lyme-disease-in-primary-health-care-centres
#20
María Esther Vázquez-López, Gonzalo Fernández, Pablo Díaz, Carolina Díez-Morrondo, Robustiano Pego-Reigosa, Amparo Coira-Nieto
OBJECTIVE: The main aim of this study was to determine the usefulness of an early diagnosis of Lyme disease (LD) in Primary Health Care Centres (PHCC) using the ELISA test as serological screening technique. METHODS: A retrospective study (2006-2013) was performed in order to determine the anti-Borrelia seropositivity in 2,842 people at risk of having LD. The possible relationship between the environment and the area of residence with anti-Borrelia seropositivity was also studied according to the origin of the specimens (PHCC/Hospital)...
May 2, 2017: Atencion Primaria
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