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https://www.readbyqxmd.com/read/29149298/vector-borne-diseases-and-climate-change-a-european-perspective
#1
Jan C Semenza, Jonathan E Suk
Climate change has already impacted the transmission of a wide-range of vector-borne diseases in Europe, and it will continue to do so in the coming decades. Climate change has been implicated in the observed shift of ticks to elevated altitudes and latitudes, notably including the Ixodes ricinus tick species which is a vector for Lyme borreliosis and tick-borne encephalitis. Climate change is also thought to have been a factor in the expansion of other important disease vectors in Europe: Aedes albopictus (the Asian tiger mosquito), which transmits diseases such as Zika, dengue, and chikungunya, and Phlebotomus sandfly species, which transmits diseases including Leishmaniasis...
November 15, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29149281/seroreactivity-to-the-c6-peptide-in-borrelia-miyamotoi-infections-occurring-in-the-northeastern-united-states
#2
Phillip J Molloy, Karen E Weeks, Brittany Todd, Gary P Wormser
Background: There are no Food and Drug Administration (FDA) approved diagnostic tests for Borrelia miyamotoi infection, an emerging tick-borne illness in the United States. The purpose of this study was to evaluate whether the FDA-approved C6 peptide ELISA currently used to diagnose Lyme disease may potentially serve as a diagnostic test for B. miyamotoi infections. Methods: Serum specimens from 30 patients from the Northeastern United States with B. miyamotoi infection established by a polymerase chain reaction assay of a blood specimen were tested using the C6 ELISA...
November 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29137719/impact-of-patient-age-on-clinical-features-serologic-test-reactivity-and-long-term-outcome-of-culture-confirmed-early-lyme-disease
#3
Erica Weitzner, Paul Visintainer, Gary P Wormser
Whether age at time of diagnosis impacts the clinical presentation or long-term outcome of early Lyme disease is unknown. Subjects enrolled in this study had culture-confirmed early Lyme disease and were followed up annually in a long-term prospective study. Subjects ≤50years of age were compared with those who were ≥51years of age at time of study entry. Of the 283 enrolled subjects, the ≥51year old age group was significantly more likely to be female (P=0.0095) and to be compliant with long-term follow-up of at least 11years duration (P=0...
December 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29133662/a-tiny-tick-can-cause-a-big-health-problem
#4
Manuel John, M Raman, Keith Ryan
Ticks are tiny crawling bugs in the spider family that feed by sucking blood from animals. They are second only to mosquitoes as vectors of human disease, both infectious and toxic. Infected ticks spread over a hundred diseases, some of which are fatal if undetected. They spread the spirochete (which multiplies in the insect's gut) with a subsequent bite to the next host. We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29120995/surveillance-for-lyme-disease-united-states-2008-2015
#5
Amy M Schwartz, Alison F Hinckley, Paul S Mead, Sarah A Hook, Kiersten J Kugeler
PROBLEM/CONDITION: Lyme disease is the most commonly reported vectorborne disease in the United States but is geographically focal. The majority of Lyme disease cases occur in the Northeast, mid-Atlantic, and upper Midwest regions. Lyme disease can cause varied clinical manifestations, including erythema migrans, arthritis, facial palsy, and carditis. Lyme disease occurs most commonly among children and older adults, with a slight predominance among males. REPORTING PERIOD: 2008-2015...
November 10, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29116038/borrelia-burgdorferi-glycosaminoglycan-binding-proteins-a-potential-target-for-new-therapeutics-against-lyme-disease
#6
Yi-Pin Lin, Lingyun Li, Fuming Zhang, Robert J Linhardt
The spirochete bacterium Borrelia burgdorferisensu lato is the causative agent of Lyme disease, the most common vector-borne disease in Europe and the United States. The spirochetes can be transmitted to humans via ticks, and then spread to different tissues, leading to arthritis, carditis and neuroborreliosis. Although antibiotics have commonly been used to treat infected individuals, some treated patients do not respond to antibiotics and experience persistent, long-term arthritis. Thus, there is a need to investigate alternative therapeutics against Lyme disease...
November 8, 2017: Microbiology
https://www.readbyqxmd.com/read/29115676/lyme-disease-presenting-with-raeder-syndrome
#7
A Budhram, C Le, M E Jenkins
No abstract text is available yet for this article.
November 8, 2017: Headache
https://www.readbyqxmd.com/read/29113783/multiple-legumain-isoenzymes-in-ticks
#8
David Hartmann, Radek Šíma, Jitka Konvičková, Jan Perner, Petr Kopáček, Daniel Sojka
By searching nucleotide databases for the North American Lyme disease vector, Ixodes scapularis, we have complemented the previously characterized European Ixodes ricinus legumain IrAE1 with a full set of nine analogous genes (isae1-9). Six of these were PCR confirmed as genes present in all tick genomes tested. The absolute mRNA copy number examined by quantitative (q)PCR enabled expression profiling and an absolute comparison of mRNA levels for individual I. scapularis (Is)AEs in tick tissues. Four IsAEs (1, 2, 4, 9) were expressed solely in the gut and thus are proposed to be involved in host blood digestion...
November 4, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/29109071/health-information-seeking-patterns-of-the-general-public-and-indications-for-disease-surveillance-register-based-study-using-lyme-disease
#9
Samuli Pesälä, Mikko J Virtanen, Jussi Sane, Pekka Mustonen, Minna Kaila, Otto Helve
BACKGROUND: People using the Internet to find information on health issues, such as specific diseases, usually start their search from a general search engine, for example, Google. Internet searches such as these may yield results and data of questionable quality and reliability. Health Library is a free-of-charge medical portal on the Internet providing medical information for the general public. Physician's Databases, an Internet evidence-based medicine source, provides medical information for health care professionals (HCPs) to support their clinical practice...
November 6, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29105221/analysis-of-recombinational-switching-at-the-antigenic-variation-locus-of-the-lyme-spirochete-using-a-novel-pacbio-sequencing-pipeline
#10
Theodore B Verhey, Mildred Castellanos, George Chaconas
The Lyme disease spirochete evades the host immune system by combinatorial variation of VlsE, a surface antigen. Antigenic variation occurs via segmental gene conversion from contiguous silent cassettes into the vlsE locus. Because of the high degree of similarity between switch variants and the size of vlsE, short-read NGS technologies have been unsuitable for sequencing vlsE populations. Here we use PacBio sequencing technology coupled with the first fully-automated software pipeline (VAST) to accurately process NGS data by minimizing error frequency, eliminating heteroduplex errors and accurately aligning switch variants...
November 4, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/29102094/early-disseminated-lyme-disease-masquerading-as-mononucleosis-a%C3%A2-case-report
#11
Richard Tumminello, Lindsey Glaspey, Anita Bhamidipati, Patrick Sheehan, Sundip Patel
BACKGROUND: Disseminated Lyme disease can be difficult to diagnose, as it begins with nonspecific signs and symptoms, which, if not treated correctly, can lead to atrioventricular conduction blocks and meningitis. In addition, the diagnosis can be further complicated by potentially false-positive test results. CASE REPORT: We report a case of early-disseminated Lyme disease presenting with Borrelia meningitis and concomitant Lyme carditis, which was misdiagnosed as mononucleosis...
October 25, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29099929/transcriptome-assessment-of-erythema-migrans-skin-lesions-in-patients-with-early-lyme-disease-reveals-predominant-interferon-signaling
#12
Adriana Marques, Ira Schwartz, Gary P Wormser, Yanmei Wang, Ronald L Hornung, Cumhur Y Demirkale, Peter J Munson, Siu-Ping Turk, Carla Williams, Chyi-Chia Richard Lee, Jun Yang, Mary M Petzke
Background: The most common clinical manifestation of early Lyme disease is the erythema migrans (EM) skin lesion that develops at the tick bite site typically between 7 and 14 days following infection with Borreliella burgdorferi. The host-pathogen interactions that occur in the skin may have a critical role in determining outcome of infection. Methods: Gene arrays were utilized to characterize the global transcriptional alterations in skin biopsy samples of EM lesions from untreated adult patients with Lyme disease in comparison to controls...
November 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29081134/-analysis-of-1874-cases-of-lyme-disease-in-domestic-literature
#13
D D Li, D M Shi, L Song
No abstract text is available yet for this article.
August 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29075628/selective-essential-oils-from-spice-or-culinary-herbs-have-high-activity-against-stationary-phase-and-biofilm-borrelia-burgdorferi
#14
Jie Feng, Shuo Zhang, Wanliang Shi, Nevena Zubcevik, Judith Miklossy, Ying Zhang
Although the majority of patients with acute Lyme disease can be cured with the standard 2-4 week antibiotic treatment, about 10-20% of patients continue suffering from chronic symptoms described as posttreatment Lyme disease syndrome. While the cause for this is debated, one possibility is that persister bacteria are not killed by the current Lyme antibiotics and remain active in the system. It has been reported that essential oils have antimicrobial activities and some have been used by patients with persisting Lyme disease symptoms...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29073126/notes-from-the-field-high-volume-of-lyme-disease-laboratory-reporting-in-a-low-incidence-state-arkansas-2015-2016
#15
Natalie A Kwit, Elizabeth A Dietrich, Christina Nelson, Richard Taffner, Jeannine Petersen, Martin Schriefer, Paul Mead, Susan Weinstein, Dirk Haselow
No abstract text is available yet for this article.
October 27, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29064060/regulation-of-gene-and-protein-expression-in-the-lyme-disease-spirochete
#16
Brian Stevenson, Janakiram Seshu
The infectious cycle of Borrelia burgdorferi necessitates persistent infection of both vertebrates and ticks, and efficient means of transmission between those two very different types of hosts. The Lyme disease spirochete has evolved mechanisms to sense its location in the infectious cycle, and use that information to control production of the proteins and other factors required for each step. Numerous components of borrelial regulatory pathways have been characterized to date. Their effects are being pieced together, thereby providing glimpses into a complex web of cooperative and antagonistic interactions...
October 25, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/29061482/irc2-bf-a-yeast-and-borrelia-responsive-component-of-the-complement-system-from-the-hard-tick-ixodes-ricinus
#17
Veronika Urbanová, Ondřej Hajdušek, Radek Šíma, Zdeněk Franta, Helena Hönig-Mondeková, Lenka Grunclová, Pavla Bartošová-Sojková, Marie Jalovecká, Petr Kopáček
Ticks possess components of a primordial complement system that presumably play a role in the interaction of the tick immune system with tick-borne pathogens and affect their transmission. Here we characterized a novel complement component, tagged as IrC2/Bf, from the hard tick Ixodes ricinus, the principal vector of Lyme disease in Europe. IrC2/Bf is a multi-domain molecule composed of 5-7 CCP modules, varied by alternative splicing, followed by a von Willebrand factor A domain and a C-terminal trypsin-like domain...
October 20, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29046884/selective-intrathecal-enrichment-of-g1m1-positive-b-cells-in-multiple-sclerosis
#18
Andreas Lossius, Alina Tomescu-Baciu, Trygve Holmøy, Christian A Vedeler, Egil Røsjø, Åslaug R Lorentzen, Ilaria Casetta, Frode Vartdal
Immunoglobulin gamma (IgG) heavy chain genes are associated with susceptibility to multiple sclerosis (MS) and IgG levels in the cerebrospinal fluid (CSF). However, how these variants are implicated in disease mechanisms remains unknown. Here, we show that proliferating plasmablasts expressing the G1m1 allotype of IgG1 are selectively enriched in CSF of G1m1/G1m3 heterozygous MS patients, whereas plasmablasts expressing either G1m1 or G1m3 are evenly distributed in blood. Moreover, there was a preferential intrathecal synthesis of oligoclonal IgG1 of the G1m1 allotype in heterozygous patients, whereas controls with Lyme neuroborreliosis displayed oligoclonal IgG1 of both allotypes...
October 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29044082/rickettsial-retinitis-direct-bacterial-infection-or-an-immune-mediated-response
#19
Rohan Chawla, Gadkar Amit Pundlik, Rama Chaudhry, Chandan Thakur
Infectious retinitis postfebrile illness is known to be caused by chikungunya, dengue, West Nile virus, Bartonella, Lyme's disease, Rift Valley fever, rickettsia, Herpes viruses etc. Rickettsia is Gram-negative bacteria transmitted by arthropods vectors. Ocular involvement is common including conjunctivitis, keratitis, anterior uveitis, panuveitis, retinitis, retinal vascular changes, and optic nerve involvement. Retinitis lesions in rickettsia can occur because of an immunological response to the bacteria or because of direct invasion and proliferation of bacteria in the inner retina...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29040182/variable-clinical-presentations-of-babesiosis-a-case-series
#20
Pamela Paparone, Philip W Paparone
Human babesiosis continues to spread in multiple regions of the United States. It is transmitted by Ixodes species ticks, as are Lyme disease and anaplasmosis. Its variable clinical presentations, together with serologic detection limitations, require that a high index of clinical suspicion be present for prompt diagnosis. This article discusses case presentations showing the wide range of symptoms and presentations that are possible with babesiosis.
November 16, 2017: Nurse Practitioner
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