Sakura Tsutamoto, Yuina Iwasaki, Akari Shinohara, Risa Imamiya, Keiichi Samukawa, Miki Kawada-Matsuo, Hitoshi Komatsuzawa, Yui Yamada, Kouki Mandokoro, Hiroshi Iwao, Yasuhiko Horiguchi, Mayuko Osada-Oka
The triterpenoid saponins, ginsenosides, are the major bioactive compound of red ginseng and can exert various physiological activities. In the present study, we examined whether red ginseng extract (RGE) exerts antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). RGE had no bactericidal activity, at least in the range of dissolvable concentration. However, RGE reduced 0.03-0.25-fold the minimum inhibitory concentration (MIC) values of β-lactam antibiotics (oxacillin, ampicillin, carbenicillin, and cefazolin) and aminoglycoside antibiotics (kanamycin and gentamicin) against the two laboratory strains of MRSA...
April 22, 2024: Microbiology Spectrum