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https://www.readbyqxmd.com/read/29232586/synthesis-and-biological-evaluation-of-coumarin-derivatives-containing-imidazole-skeleton-as-potential-antibacterial-agents
#1
Yang Hu, Yufeng Shen, Xiaohu Wu, Xiao Tu, Gao-Xue Wang
Emergence of multidrug-resistant bacteria causes an urgent need for new generation of antibiotics, which may have a different mechanism of inhibition or killing action from the existing. Here, we report on the design, synthesis, and biological evaluation of thirty-nine coumarin derivatives in order to solve the antibacterial resistance by targeting at the inhibition of biosynthesis pathway of fatty acids. Their antibacterial activities against Escherichia coli, Staphylococcus aureus, Streptococcus agalactiae, and Flavobacterium cloumnare are tested and action mechanism against the key enzyme in bacterial fatty acid synthesis pathway are studied...
December 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29232578/hetero-diels-alder-reactions-of-novel-3-triazolyl-nitrosoalkenes-as-an-approach-to-functionalized-1-2-3-triazoles-with-antibacterial-profile
#2
Susana M M Lopes, Juliana S Novais, Dora C S Costa, Helena C Castro, Agnes Marie S Figueiredo, Vitor F Ferreira, Teresa M V D Pinho E Melo, Fernando de Carvalho da Silva
The generation and reactivity of 3-triazolyl-nitrosoalkenes are reported for the first time. The study showed that hetero-Diels-Alder reaction of these heterodienes is an interesting synthetic strategy to functionalized 1,2,3-triazoles, including 1,2,3-triazolyl-pyrroles, 1,2,3-triazolyl-dipyrromethanes and 1,2,3-triazolyl-indoles. The evaluation of the antibacterial profile against Gram-positive and Gram-negative strains revealed the new 5,5'-diethyldipyrromethane bearing a side chain incorporating a triazole and oxime moieties...
November 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29232416/berberine-from-argemone-mexicana-l-exhibits-a-broadspectrum-antibacterial-activity
#3
Nilesh V More, Kiran R Kharat, Arun S Kharat
The Argemone mexicana L, commonly found on desolate land in the Marathwada region of Maharashtra state, India, has been used for treating oral cavity infections. We sought to investigate the antimicrobial potential of A. mexicana L. In this study, cold aqueous and methanolic extracts were prepared from the A. mexicana L leaves. These extracts were tested for their antibacterial activities against selected bacterial isolates. The antibacterial activity and MICs were tested using the agar well diffusion method and broth dilution method, respectively...
December 13, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29232113/hyperbranched-polyglycerol-loaded-with-zinc-porphyrins-photosensitizer-release-under-reductive-and-acidic-conditions-for-improved-photodynamic-therapy
#4
Michael H Staegemann, Susanna Gräfe, Burkhard Gitter, Katharina Achazi, Elisa Quaas, Rainer Haag, Arno Wiehe
An adaptable approach toward cleavable nanoparticle carrier systems for photodynamic therapy (PDT) is presented, comprising a biocompatible carrier loaded with multiple photosensitizer (PS) molecules related to the clinically employed PS Temoporfin, two linkers cleavable under different triggers and glyco-targeting with mannose. A synthetic pathway to stimuli responsive hyperbranched polyglycerol (hPG) porphyrin conjugates via the copper(I)-catalyzed 1,3-dipolar cycloaddition (CuAAC) or the strain-promoted alkyne-azide cycloaddition (SPAAC) has been developed...
December 12, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29231891/bioactive-compounds-produced-by-hypoxylon-fragiforme-against-staphylococcus-aureus-biofilms
#5
Kamila Tomoko Yuyama, Clara Chepkirui, Lucile Wendt, Diana Fortkamp, Marc Stadler, Wolf-Rainer Abraham
Treating infections organized in biofilms is a challenge due to the resistance of the pathogens against antibiotics and host immune cells. Many fungi grow in a wet environment, favorable for the growth of bacterial biofilms, and we speculated that fungi possess some strategies to control these bacterial biofilms. A fungus identified as Hypoxylon fragiforme, was collected in the Harz Mountains, Germany, and its mycelial culture was fermented in different culture media for 67 days to test its biological potential against bacterial biofilms...
December 12, 2017: Microorganisms
https://www.readbyqxmd.com/read/29231844/collismycin-c-from-the-micronesian-marine-bacterium-streptomyces-sp-mc025-inhibits-staphylococcus-aureus-biofilm-formation
#6
Jin-Hyung Lee, Eonmi Kim, Hyukjae Choi, Jintae Lee
Biofilm formation plays a critical role in antimicrobial resistance in Staphylococcus aureus. Here, we investigated the potential of crude extracts of 79 Micronesian marine microorganisms to inhibit S. aureus biofilm formation. An extract of Streptomyces sp. MC025 inhibited S. aureus biofilm formation. Bioactivity-guided isolation led to the isolation of a series of 2,2'-bipyridines: collismycin B (1), collismycin C (2), SF2738 D (3), SF2738 F (4), pyrisulfoxin A (5), and pyrisulfoxin B (6). Among these bipyridines, collismycin C (2) was found to be the most effective inhibitor of biofilm formation by methicillin-sensitive S...
December 12, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29231774/modern-management-of-diabetic-foot-osteomyelitis-the-when-how-and-why-of-conservative-approaches
#7
Javier Aragón-Sánchez, Benjamin A Lipsky
Introduction Diabetic foot osteomyelitis (DFO) has long been considered a complex infection that is both difficult to diagnose and treat, and is associated with a high rate of relapse and limb loss. Areas covered DFO can usually be diagnosed by a combination of clinical evaluation, serum inflammatory markers and plain X-ray. When the results of these procedures are negative or contradictory, advanced imaging tests or bone biopsy may be necessary. Staphylococcus aureus remains the most frequent microorganism isolated from bone specimens, but infection is often polymicrobial...
December 12, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29231172/cefazolin-and-coagulation-disorders-a-case-report
#8
Eugénie Gay, Anne Barthel, Nicolas Rouzic, Basile Henriot, Baptiste Quélennec, Aurélien Lorleac'h, Nathalie Prades, François Schmitt
We report the case of a 79-year-old patient, admitted to the department of infectious diseases at Bretagne Sud Hospital Center for a right calcaneal osteitis, complicated by a pacemaker leads infectious endocarditis. Meticillin sensitive Staphylococcus aureus was documented by blood culture. Antibiotic treatment was established using intravenous cefazolin for an initial 6 weeks period. Prothrombin time (PT) decreased as well as vitamin K dependent factors, without anticoagulation therapy, at day 7 of cefazolin treatment...
December 12, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29230489/-potential-of-allogeneic-bone-grafts-as-antibiotic-carriers-effect-of-different-preparation-processes-on-efficacy
#9
REVIEW
D C Coraça-Huber, M Nogler, K-D Kühn
BACKGROUND: The rising number of primary joint replacements worldwide is causing an increase of endoprosthetic revision surgery due bacterial infection. Revision surgery using non-cemented implants seems beneficial for the long-term outcome, and the use of antibiotic-impregnated bone grafts might control the infection and provide a good support for the implant. In this study, we evaluated the release of antibiotics from fresh-frozen and lyophilized allogeneic bone grafts. METHODS: Heat-treated, lyophilized and fresh frozen cryopreserved bone chips were impregnated with gentamicin sulphate, gentamicin palmitate and vancomycin, and calcium carbonate/calcium sulphate treated with antibiotics...
December 11, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/29230405/variability-of-chemical-compositions-and-antimicrobial-and-antioxidant-activities-of-ruta-chalepensis-leaf-essential-oils-from-three-palestinian-regions
#10
Nidal Jaradat, Lina Adwan, Shadi K'aibni, Abdel Naser Zaid, Munqez J Y Shtaya, Naser Shraim, Mohyeddin Assali
Introduction: Interest in essential oils was recently revived with their popularity increasing in medicine, pharmacy, and aromatherapy. This study was performed to identify the chemical compositions of the essential oil of Ruta chalepensis growing wildly in three regions in Palestine and to assess and compare their antimicrobial and antioxidant activities. Methods: Identification of the essential oil was performed by gas chromatography coupled with mass spectrometry (GC-MS)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29230259/-nosocomial-urinary-tract-and-surgical-site-infection-rates-in-the-maternity-ward-at-the-general-referral-hospital-in-katuba-lubumbashi-democratic-republic-of-the-congo
#11
Hendrick Mbutshu Lukuke, Eric Kasamba, Abdulu Mahuridi, Roger Ngatu Nlandu, Suganuma Narufumi, Abel Ntambue Mukengeshayi, Vicky Malou, Michel Makoutode, Françoise Malonga Kaj
Introduction: In Intertropical Africa hospitalized patients are exposed to a risk of nosocomial infections. The dearth of published data on this subject limits the descriptive analysis of the situation. This study aimed to determine the incidence, the germs responsible for these infections and the risk factors of nosocomial infections in the Maternity Ward at the General Referral Hospital in Katuba, Lubumbashi, Democratic Republic of the Congo. Methods: We conducted a descriptive, longitudinal study from 1 October 2014 to 1 January 2015...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29230205/bacterial-genetic-architecture-of-ecological-interactions-in-co-culture-by-gwas-taking-escherichia-coli-and-staphylococcus-aureus-as-an-example
#12
Xiaoqing He, Yi Jin, Meixia Ye, Nan Chen, Jing Zhu, Jingqi Wang, Libo Jiang, Rongling Wu
How a species responds to such a biotic environment in the community, ultimately leading to its evolution, has been a topic of intense interest to ecological evolutionary biologists. Until recently, limited knowledge was available regarding the genotypic changes that underlie phenotypic changes. Our study implemented GWAS (Genome-Wide Association Studies) to illustrate the genetic architecture of ecological interactions that take place in microbial populations. By choosing 45 such interspecific pairs of Escherichia coli and Staphylococcus aureus strains that were all genotyped throughout the entire genome, we employed Q-ROADTRIPS to analyze the association between single SNPs and microbial abundance measured at each time point for bacterial populations reared in monoculture and co-culture, respectively...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29230089/study-on-effects-of-titanium-surface-microporous-coatings-containing-zinc-on-osteoblast-adhesion-and-its-antibacterial-activity
#13
Quan-Ming Zhao, Guang-Zhong Li, Hao-Ming Zhu, Li Cheng
Metal surface structure/biomedical function integration is the current research focus. In previous studies, we have successfully prepared the microporous coatings containing zinc on the pure titanium surface by MAO. In the study, osteoblasts were seeded on the surface of the microporous coatings containing zinc and the adhesion of osteoblasts were evaluated, and the antibacterial activity of the microporous coatings containing zinc is observed through in vitro bacterial experiments. The result indicates that the adhesion ability of osteoblasts on the surface of microporous coatings containing zinc was very good, and the coatings could obviously inhibit the growth of Staphylococcus aureus and had good antibacterial activity...
2017: Applied Bionics and Biomechanics
https://www.readbyqxmd.com/read/29229883/in-vitro-leishmanicidal-antibacterial-and-antitumour-potential-of-anhydrocochlioquinone-a-obtained-from-the-fungus-cochliobolus-sp
#14
Fernanda F Campos, Jonas P Ramos, Djalma M DE Oliveira, Tania M A Alves, Elaine M DE Souza-Fagundes, Carlos L Zani, Fabio C Sampaio, Attilio Converti, Betania B Cota
The bioassay-guided fractionation of the ethyl acetate extract of the fungus Cochliobolus sp. highlighted leishmanicidal activity and allowed for anhydrocochlioquinone A (ANDC-A) isolation. MS, 1D and 2D NMR spectra of this compound were in agreement with those published in the literature. ANDC-A exhibited leishmanicidal activity with EC 50 value of 22.4 microgram/mL (44 mu M) and, when submitted to the microdilution assay against Gram-ositive and Gram-negative bacteria, showed a minimal inhibitory concentration against Staphylococcus aureus ATCC 25295 of 128 microgram/mL (248...
December 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/29229737/the-superantigen-toxic-shock-syndrome-toxin-1-alters-human-aortic-endothelial-cell-function
#15
Katarina Kulhankova, Kyle J Kinney, Jessica M Stach, Françoise A Gourronc, Isabella M Grumbach, Aloysius J Klingelhutz, Wilmara Salgado-Pabón
Staphylococcus aureus infective endocarditis (IE) is a fast-progressing and tissue destructive infection of the cardiac endothelium. The superantigens (SAgs) toxic shock syndrome toxin-1 (TSST-1), staphylococcal enterotoxin C (SEC), and the enterotoxin gene cluster (egc) play a novel and essential role in the etiology of S. aureus IE. Recent studies indicate that SAgs act at the infection site to cause tissue pathology and promote vegetation growth. The underlying mechanism of SAg involvement has not been clearly defined...
December 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29229636/topical-antibiotic-use-co-selects-for-the-carriage-of-mobile-genetic-elements-conferring-resistance-to-unrelated-antimicrobials-in-staphylococcus-aureus
#16
Glen P Carter, Mark B Schultz, Sarah L Baines, Anders Goncalves da Silva, Helen Heffernan, Audrey Tiong, Peter H Pham, Ian R Monk, Timothy P Stinear, Benjamin P Howden, Deborah A Williamson
Topical antibiotics such as mupirocin and fusidic acid are commonly used in the prevention and treatment of skin infections, particularly those caused by staphylococci. However, widespread use of these agents is associated with increased resistance to these agents, potentially limiting their efficacy. Of particular concern is the observation that resistance to topical antibiotics is often associated with multidrug resistance, suggesting that topical antibiotics may play a role in the emergence of multidrug-resistant (MDR) strains...
December 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29229527/surface-proteins-and-the-formation-of-biofilms-by-staphylococcus-aureus
#17
Sung Joon Kim, James Chang, Binayak Rimal, Hao Yang, Jacob Schaefer
Staphylococcus aureus biofilms pose a serious clinical threat as reservoirs for persistent infections. Despite this clinical significance, the composition and mechanism of formation of S. aureus biofilms are unknown. To address these problems, we used solid-state NMR to examine S. aureus (SA113), a strong biofilm-forming strain. We labeled whole cells and cell walls of planktonic cells, young biofilms formed for 12-24h after stationary phase, and more mature biofilms formed for up to 60h after stationary phase...
December 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29229504/an-inhibitory-action-of-chitosan-nanoparticles-against-pathogenic-bacteria-and-fungi-and-their-potential-applications-as-biocompatible-antioxidants
#18
D MubarakAli, F LewisOscar, V Gopinath, Naify S Alharbi, Sulaiman Ali Alharbi, N Thajuddin
Chitosan is the second most abundant polymer obtained from the byproduct of seafood. Chitosan and its derivatives and chitosan loaded drugs are the recent area of interest against microbial pathogenesis. The cationic chitosan nanoparticles (ChNPs) interact with the anionic surfaces of the microbial cell membrane, which promotes antimicrobial activity. Although, ChNPs are potential against pathogenic microbes, selection of adaptable, suitable and cost effective synthesis method is much important. In the present study, ChNPs were synthesized adopting ionic gelation using sodium tripolyphosphate as a cross linking agent and characterized by FTIR, DLS, SEM and TEM analysis...
December 8, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29229242/synthesis-characterisation-and-biomedical-applications-of-curcumin-conjugated-chitosan-microspheres
#19
T S Saranya, V K Rajan, Raja Biswas, R Jayakumar, S Sathianarayanan
Curcumin is a diaryl heptanoid of curcuminoids class obtained from Curcuma longa. It possesses various biological activities like anti-inflammatory, hypoglycemic, antioxidant, wound-healing, and antimicrobial activities. Chitosan is a biocompatible, biodegradable and non-toxic natural polymer which enhances the adhesive property of the skin. Chemical conjugation will leads to sustained release action and to enhance the bioavailability. This study aims to synthesis and characterize biocompatible curcumin conjugated chitosan microspheres for bio-medical applications...
December 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29229120/susceptibility-of-eptfe-vascular-grafts-and-bioengineered-human-acellular-vessels-to-infection
#20
Robert D Kirkton, Heather L Prichard, Maribel Santiago-Maysonet, Laura E Niklason, Jeffrey H Lawson, Shannon L M Dahl
BACKGROUND: Synthetic expanded polytetrafluorethylene (ePTFE) grafts are routinely used for vascular repair and reconstruction but prone to sustained bacterial infections. Investigational bioengineered human acellular vessels (HAVs) have shown clinical success and may confer lower susceptibility to infection. Here we directly compared the susceptibility of ePTFE grafts and HAV to bacterial contamination in a preclinical model of infection. MATERIALS AND METHODS: Sections (1 cm2) of ePTFE (n = 42) or HAV (n = 42) were inserted within bilateral subcutaneous pockets on the dorsum of rats and inoculated with Staphylococcus aureus (107 CFU/0...
January 2018: Journal of Surgical Research
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