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Irisin

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https://www.readbyqxmd.com/read/29775761/the-bone-anabolic-effects-of-irisin-are-through-preferential-stimulation-of-aerobic-glycolysis
#1
Dingdong Zhang, ChuHyun Bae, Junghak Lee, Jiho Lee, Zeyu Jin, Myeongmo Kang, Young Suk Cho, Jeong-Han Kim, Weontae Lee, Sung-Kil Lim
Irisin, a recently identified hormone secreted by skeletal muscle in response to exercise, exhibits anabolic effects on the skeleton primarily through the stimulation of bone formation. However, the mechanism underlying the irisin-stimulated anabolic response remains largely unknown. To uncover the underlying mechanism, we biosynthesized recombinant irisin (r-irisin) using an Escherichia coli expression system and used it to treat several osteoblast cell types. Our synthesized r-irisin could promote proliferation and differentiation of osteoblasts as evidenced by enhanced expression of osteoblast-specific transcriptional factors, including Runt-related transcription factor-2 (Runx2), Oster (Osx), as well as early osteoblastic differentiation markers such as alkaline phosphatase (Alp) and collagen type I alpha 1 (Col1a1)...
May 15, 2018: Bone
https://www.readbyqxmd.com/read/29771602/irisin-promotes-proliferation-but-inhibits-differentiation-in-osteoclast-precursor-cells
#2
Yaxian Ma, Xiaoyong Qiao, Rujun Zeng, Ran Cheng, Jun Zhang, Yunyao Luo, Ying Nie, Ying Hu, Zhilan Yang, Jing Zhang, Lin Liu, Wenming Xu, Charles C Xu, Liangzhi Xu
The receptor activator of NF-κB ligand-induced osteoclast differentiation has a critical role in the process of bone metabolism. Overactivation of osteoclastogenesis may result in a series of diseases. Irisin, a novel myokine, which was first reported in 2012, has been proposed to mediate the beneficial metabolic effects of exercise. Studies have demonstrated that irisin targets osteoblasts by promoting osteoblast proliferation and differentiation; however, the underlying mechanism regarding the effect of irisin on osteoclasts remains elusive...
May 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29769428/myokine-irisin-induced-protection-against-oxidative-stress-in-vitro-involvement-of-heme-oxygenase-1-and-antioxidazing-enzymes-superoxide-dismutase-2-and-glutathione-peroxidase
#3
A I Mazur-Bialy, K Kozlowska, E Pochec, J Bilski, T Brzozowski
Irisin is a recently discovered myokine reported as protective protein released from exercising skeletal muscles. Although myokines were recently reported to possess the antioxidizing properties, the impact of irisin on the functions of macrophages with respect to its anti-inflammatory potential has not been fully elucidated. Here, we determined the ability of irisin to interact with reactive oxygen species (ROS) in RAW 264.7 murine macrophages. The macrophages were pre-incubated with irisin (0 - 50 nM), some of which had undergone additional co-incubation with bacterial lipopolysaccharide (LPS) (100 ng/ml)...
February 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29761269/effects-of-running-a-marathon-on-irisin-concentration-in-men-aged-over-50
#4
Paweł Jóźków, Dawid Koźlenia, Katarzyna Zawadzka, Marek Konefał, Paweł Chmura, Katarzyna Młynarska, Michał Kosowski, Marek Mędraś, Jan Chmura, Piotr Ponikowski, Jacek Daroszewski
Our aim was to verify whether running a marathon is associated with changes in irisin concentration in healthy, endurance-trained men. In an observational study, we assessed baseline biochemical and fitness parameters of 28 middle-aged runners (mean ± SD age, BMI, VO2max : 58 ± 8 years; 24.5 ± 3 kg/m2 ; 51.1 ± 1.7 ml/kg/min). We evaluated irisin before, immediately after, and 7 days after the marathon. Irisin concentration decreased from a baseline value of 639 ± 427 to 461 ± 255 ng/ml immediately after the marathon (p < 0...
May 14, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29749315/irisin-in-coronary-bypass-surgery
#5
Suna Aydin, Zekiye Catak, Mehmet Nesimi Eren, Suleyman Aydin, Askin Ender Topal
INTRODUCTION: In coronary bypass surgery, after cardiopulmonary bypass is initiated by arterial cannulation in the ascending aorta and venous cannulation through a single vein generally in the right atrium, the process of cooling the patient is started. There is a relation between cooling the patient and irisin, which is responsible for releasing heat. OBJECTIVE: Therefore, the main objective of the present study is to explore how irisin concentrations and some other panel of myocardium injury in patients undergoing coronary artery bypass surgery changes...
May 11, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29745314/obesity-and-its-association-with-irisin-level-among-individuals-with-fndc5-irisin-gene-variants-rs16835198-and-rs726344
#6
Azza Abdu Allah, Eman Abd El Gayed, Sahar Hammoudah, Lama Mohamed El-Attar, Walid Shehab-Eldin
BACKGROUND: Irisin; a novel myokine/adipokine; encoded by FNDC5 gene have been suggested to play an important role in energy metabolism and obesity. However, the genetic variations at this locus and their effects on different metabolic parameters is still poorly understood. AIM: This study aimed to investigate the role of FNDC5/irisin gene polymorphisms (RS16835198 and RS726344) in obese individuals and their genotype phenotype correlation with circulating serum irisin level and other biochemical parameters like glucose, lipid metabolism and liver enzymes...
May 8, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29738032/does-high-intensity-exercise-affects-irisin-plasma-levels-in-hemodialysis-patients-a-pilot-study
#7
Marta Gormicho Boavida Marques Esgalhado, Milena Barcza Stockler-Pinto, Ludmila Ferreira Medeiros de França Cardozo, Jorge Eduardo Barboza, Denise Mafra
BACKGROUND: Irisin is a recently identified exercise-induced hormone that stimulates the "browning" of the white adipose tissue, at least in mice. In chronic kidney disease (CKD) patients, irisin regulation is not fully understood, and little attention has been given to the effects of exercise on irisin levels in these patients. The purpose of this study was to assess the effects of high intensity exercise on irisin plasma levels in CKD patients under hemodialysis (HD). METHODS: Fifteen HD patients (5 men, 44...
April 23, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29730451/the-effects-of-fasting-and-appetite-regulators-on-catecholamine-and-serotonin-synthesis-pathways-in-goldfish-carassius-auratus
#8
Stephanie Mandic, Hélène Volkoff
Monoamine neurotransmitters such as catecholamines [dopamine (DA), norepinephrine (NE) and epinephrine (E)] and serotonin have been shown to influence feeding in vertebrates. In order to better understand the role of monoamine neurotransmitters in the regulation of feeding in fish, we examined the effects of fasting on the brain and intestine gene expression of enzymes involved in their synthesis pathways (SPR: sepiapterin reductase; DHPR: dihydropteridine reductase; TH: tyrosine hydroxylase; TPH: tryptophan hydroxylase; AADC: aromatic l-amino acid decarboxylase; DBH: dopamine β-hydroxylase) in goldfish...
May 3, 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29729148/brown-adipose-tissue-in-young-adults-who-were-born-preterm-or-small-for-gestational-age
#9
Anna Kistner, Henric Rydén, Björn Anderstam, Ann Hellström, Mikael Skorpil
BACKGROUND: Brown adipose tissue (BAT) is present and functions to dissipate energy as heat in young adults and can be assessed using magnetic resonance imaging (MRI) to estimate the voxel fat fraction, i.e. proton density fat fraction (PDFF). It is hypothesized that subjects born preterm or small for gestational age (SGA) may exhibit disrupted BAT formation coupled to metabolic factors. Our purpose was to assess the presence of BAT in young adults born extremely preterm or SGA in comparison with controls...
May 5, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29720216/decreased-level-of-irisin-a-skeletal-muscle-cell-derived-myokine-is-associated-with-post-stroke-depression-in-the-ischemic-stroke-population
#10
Wen-Jun Tu, Han-Cheng Qiu, Qiang Liu, Xuemei Li, Ji-Zong Zhao, Xianwei Zeng
BACKGROUND: Depression is a frequent mood disorder in stroke patient. Our aim was to determine irisin levels in serum and investigate their associations with post-stroke depression (PSD) in a 6-month follow-up study in Chinese patients with first-ever acute ischemic stroke (AIS). METHODS: The subjects were first-ever AIS patients who were hospitalized at three stroke centers during the period from January 2015 to December 2016. Neurological and neuropsychological evaluations were conducted at the 6-month follow-up...
May 2, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29719446/ursolic-acid-in-health-and-disease
#11
REVIEW
Dae Yun Seo, Sung Ryul Lee, Jun-Won Heo, Mi-Hyun No, Byoung Doo Rhee, Kyung Soo Ko, Hyo-Bum Kwak, Jin Han
Ursolic acid (UA) is a natural triterpene compound found in various fruits and vegetables. There is a growing interest in UA because of its beneficial effects, which include anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-carcinogenic effects. It exerts these effects in various tissues and organs: by suppressing nuclear factor-kappa B signaling in cancer cells, improving insulin signaling in adipose tissues, reducing the expression of markers of cardiac damage in the heart, decreasing inflammation and increasing the level of anti-oxidants in the brain, reducing apoptotic signaling and the level of oxidants in the liver, and reducing atrophy and increasing the expression levels of adenosine monophosphate-activated protein kinase and irisin in skeletal muscles...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29703023/serum-irisin-associates-with-breast-cancer-to-spinal-metastasis
#12
Zheng-Ping Zhang, Xue-Fang Zhang, Hui Li, Tuan-Jiang Liu, Qin-Peng Zhao, Lin-Hong Huang, Zi-Jun Cao, Li-Min He, Ding-Jun Hao
The aim of this study was to determine whether the serum level of irisin can be a candidate to predict the spinal metastasis in patients with breast cancer.In a cross-sectional study, 148 patients were recruited. Of those, 53 (35.8%) had spinal metastasis. The baseline characteristics were compared by status of spinal metastasis. Multiple logistic regression analysis was used to determine whether the serum irisin can be a candidate for predicting breast cancer to spinal metastasis. The correlation coefficient analysis was used to confirm the correlation between the serum irisin and lipid metabolic parameters and body mass index (BMI), respectively...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29679630/high-irisin-levels-are-associated-with-better-glycemic-control-and-bone-health-in-children-with-type-1-diabetes
#13
Maria Felicia Faienza, Giacomina Brunetti, Lorenzo Sanesi, Graziana Colaianni, Monica Celi, Laura Piacente, Gabriele D'Amato, Ernestina Schipani, Silvia Colucci, Maria Grano
AIM: Irisin is a new peptide produced mainly by the skeletal muscle playing an important role both in glucose/energy homeostasis and bone metabolism. Childhood type 1 diabetes mellitus (T1DM) is associated with decreased bone mass. We aimed to evaluate irisin levels in TD1M children and their correlation with bone metabolism and glycaemic control. METHODS: Ninety-six T1DM subjects (12.2 ± 4 years), 56 on multiple daily injections (MDI), 40 on continuous subcutaneous insulin infusion (CSII), and 34 controls were included in the study...
April 19, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29673927/novel-adipokines-vaspin-and-irisin-as-risk-biomarkers-for-cardiovascular-diseases-in-type-2-diabetes-mellitus
#14
Dalia H El-Lebedy, Alshaymaa A Ibrahim, Ingy O Ashmawy
AIMS: Vaspin and irisin are novel cytokines proposed as potential new biomarkers of insulin resistance and endothelial dysfunction. This work is to investigate circulating levels of vaspin and irisin in patients with type 2 diabetes mellitus (T2DM) with and without cardiovascular disease (CVD) to study potential association with disease risk. MATERIALS AND METHODS: Circulating levels of vaspin and irisin were assayed in serum from 135 T2DM patients (with and without CVD) and 70 control subjects by ELISA...
April 12, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29670915/association-of-markers-of-proinflammatory-phenotype-and-beige-adipogenesis-with-metabolic-syndrome-in-chinese-centrally-obese-adults
#15
Wilson K C Leung, Angus P Yu, Christopher W K Lai, Parco M Siu
Background: Visceral adiposity is associated with higher productions of C-reactive protein (CRP) and interleukin-6 (IL-6). Inflammation of obese adipose tissues could contribute to systemic metabolic dysregulation, especially thermogenic activity of white adipose tissues, namely, beige adipogenesis, characterized by altered irisin expression. Thus, we investigated the roles of inflammation and adipocyte beiging in Chinese centrally obese (CO) adults with metabolic syndrome (MetS). Methods: This cross-sectional study was conducted on 54 CO and 58 non-CO subjects drawn from 1492 Chinese people with age and sex matched during November 2010 and August 2013...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29657036/serum-irisin-levels-are-associated-with-adverse-cardiovascular-outcomes-in-patients-with-acute-myocardial-infarction
#16
I-Chang Hsieh, Ming-Yun Ho, Ming-Shien Wen, Chun-Chi Chen, Ming-Jer Hsieh, Chia-Pin Lin, Jih-Kai Yeh, Ming-Lung Tsai, Chia-Hung Yang, Victor Chien-Chia Wu, Kuo-Chun Hung, Chun-Chieh Wang, Chao-Yung Wang
Irisin, a recently identified myokine, regulates mitochondrial function and energy expenditure. The concentration of irisin is significantly altered after ST-elevation myocardial infarction (STEMI). We hypothesized that serum irisin concentration is associated with adverse cardiovascular outcomes after myocardial infarction. Serum irisin concentrations were measured using enzyme-linked immunosorbent assay (ELISA) in 399 patients 28d after the onset of STEMI in a prospective single-center cohort study. We assessed the association between irisin concentrations and adverse cardiovascular events during a 3-year follow-up...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29655944/regular-aerobic-exercise-correlates-with-reduced-anxiety-and-incresed-levels-of-irisin-in-brain-and-white-adipose-tissue
#17
Nazan Uysal, Oguz Yuksel, Servet Kizildag, Zeynep Yuce, Hikmet Gumus, Aslı Karakilic, Guven Guvendi, Basar Koc, Sevim Kandis, Mehmet Ates
We have recently shown that regular voluntary aerobic exercised rats have low levels of anxiety. Irisin is an exercise-induced myokine that is produced by many tissues; and the role it plays in anxiolytic behavior is unknown. In this study we aimed to investigate the correlation between anxiety like behavior and irisin levels following regular voluntary aerobic exercise in male mice. We've have shown that anxiety levels decreased in exercised mice, while irisin levels increased in the brain, brown adipose tissue, white adipose tissue, kidney, and pancreas tissues...
April 12, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29643769/the-role-of-physical-exercise-to-improve-the-browning-of-white-adipose-tissue-via-pomc-neurons
#18
REVIEW
Kellen C da Cruz Rodrigues, Rodrigo M Pereira, Thaís D P de Campos, Rodrigo F de Moura, Adelino S R da Silva, Dennys E Cintra, Eduardo R Ropelle, José R Pauli, Michel B de Araújo, Leandro P de Moura
Obesity is a public health issue that affects more than 600 million adults worldwide. The disease is characterized by fat accumulation, mainly in the abdominal area. The human body is mainly composed of two types of adipose tissue: white adipose tissue (WAT) and brown adipose tissue (BAT); however, the browning process generates a different type of brown fat-like adipocyte in WAT, which similar to BAT has thermogenic capacity by activating UCP-1. The hypothalamic arcuate nucleus plays an important role in WAT browning via POMC neurons, which are influenced by synergistic insulin and leptin signaling...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29629290/the-combination-of-exercise-training-and-zataria-multiflora-supplementation-increase-serum-irisin-levels-in-postmenopausal-women
#19
Abbass Ghanbari-Niaki, Ayoub Saeidi, Mehdi Ahmadian, Leila Gharahcholo, Nooshin Naghavi, Mohammad Fazelzadeh, Soleiman Mahjoub, Stephen Myers, Andrew Williams
Background: We examined the effect of antioxidant supplementation and exercise on irisin within postmenopausal women. Methods: Forty-eight participants (age: 55.7 ± 4.9 years; weight: 68.0 ± 6.3 kg; BMI 27.0 ± 2.7; mean ± SD) were randomized into four groups for the eight week intervention: control group (CG; n  = 12), resistance training group (RTG; n  = 12), supplementation with Zataria multiflora group (ZG; n  = 12), or supplementation with Z...
March 2018: Integrative Medicine Research
https://www.readbyqxmd.com/read/29609490/colostrum-and-mature-breast-milk-analysis-of-serum-irisin-and-sterol-regulatory-element-binding-proteins-1c-in-gestational-diabetes-mellitus
#20
Syeda Sadia Fatima, Erum Khalid, Asma Akbar Ladak, Syed Adnan Ali
BACKGROUND: We aimed to evaluate irisin and SREBP-1c levels in serum, colostrum and mature breast milk in women with and without gestational diabetes (GDM); and to relate them with maternal glucose, lipid profile and weight status of babies. METHODS: GDM positive women (n = 33) and normal glucose tolerant women (NGT) (n = 33) were recruited. Maternal blood samples were collected at 28th week of gestation and later at 6-week post-partum while breast milk samples of the lactating mothers were collected within 72 hours of birth (colostrum) and at 6 weeks post-partum (mature milk)...
April 2, 2018: Journal of Maternal-fetal & Neonatal Medicine
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