keyword
https://read.qxmd.com/read/38533282/serum-irisin-in-polycystic-ovary-syndrome-and-its-alteration-with-metformin-intervention
#1
JOURNAL ARTICLE
Radhakrishna Telagareddy, Padala Ravi Kumar, Sudhi Ranjan Pattanaik, Deepak Kumar Dash, Debasish Patro, Bijay K Sahoo, Mahija Sahu
INTRODUCTION: Studies investigating the alterations of serum irisin and its change with metformin therapy in patients with polycystic ovary syndrome (PCOS) are conflicting. Our aim is to study serum irisin in PCOS patients and the change of irisin levels with metformin therapy over 6 months. METHODS: This is a randomized control study conducted in 187 PCOS cases and 94 age-matched controls aged 18-40 years. Detailed evaluation of anthropometric, biochemical, and hormonal parameters was performed...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38526676/bone-formation-by-irisin-poly-vinyl-alchol-modified-bioglass-ceramic-beads-in-the-rabbit-model
#2
JOURNAL ARTICLE
Seong-Su Park, Ume Farwa, Hai-Doo Kim, Yong-Sik Kim, Byong-Taek Lee
In the aging society, slow bone regeneration poses a serious hindrance to the quality of life. To deal with this problem, in this study, we have combined irisin with the bioglass regular beads to enhance the bone regeneration process. For this purpose, highly porous bioglass was obtained as spherical beads by using sodium alginate. The bioglass was evaluated by various analytical techniques such as SEM, EDS, XRD, and pore size distribution. The results depicted that porous bioglass was prepared correctly and SEM analysis showed a highly porous bioglass was formulated...
March 25, 2024: Journal of Materials Science. Materials in Medicine
https://read.qxmd.com/read/38524822/serum-myokines-as-potential-biomarkers-of-myostatin-inhibition-in-sport-doping-a-preliminary-study-on-their-baseline-levels-in-elite-athletes
#3
JOURNAL ARTICLE
Francesco Donati, Giorgia Morgan Biasini, Xavier de la Torre, Francesco Botrè
We considered in this study the possibility of developing an indirect procedure for detecting myostatin inhibition/suppression, a practice that is prohibited as doping in sport. We have specifically considered the potential diagnostic utility of human serum myokines as indirect markers of myostatin inhibition. Myostatin, its main antagonist follistatin, and other myokines (follistatin-like 1, musclin, oncostatin, osteonectin, irisin, brain derived neurotrophic factor, and insulin-like growth factor-1) were selected as a panel of potential biomarkers whose levels may be altered following myostatine suppression...
March 2024: Biology of Sport
https://read.qxmd.com/read/38518138/changes-in-serum-irisin-levels-and-their-significance-in-carotid-atherosclerosis-associated-with-obesity
#4
JOURNAL ARTICLE
Shaohua Fu, Guisheng Xing
OBJECTIVE: This study aims to comprehensively examine and assess the changes and significance of irisin levels in individuals with carotid atherosclerosis (CAS) who are concurrently dealing with obesity. METHOD: A total of 156 CAS patients admitted between March 2020 and March 2022 were categorized into CAS normal weight (C1), CAS overweight (C2), and CAS obesity (C3) groups based on BMI. Simultaneously, 80 healthy adults from the same period comprised the control group (C0)...
March 22, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38516869/effect-of-lactobacillus-plantarum-bfs1243-on-a-female-frailty-model-induced-by-fecal-microbiota-transplantation-in-germ-free-mice
#5
JOURNAL ARTICLE
Sashuang Dong, Qi Zeng, Weimin He, Wei Cheng, Ling Zhang, Ruimin Zhong, Wen He, Xiang Fang, Hong Wei
Frailty, a complex geriatric syndrome, significantly impedes the goal of achieving 'healthy aging'. Increasing evidence suggests a connection between gut microbiota, systemic inflammation, and disease. However, it remains to be determined whether interventions targeting the intestinal flora can effectively ameliorate frailty. Our research involved fecal microbiota transplantation (FMT) experiments on germ-free (GF) mice, dividing these mice into three groups: a group receiving transplants from healthy elderly individuals (HF group), a group of frailty patients (FF group), and the FF group supplemented with Lactobacillus plantarum BFS1243 (FFL group)...
March 22, 2024: Food & Function
https://read.qxmd.com/read/38512830/trolox-and-recombinant-irisin-as-a-potential-strategy-to-prevent-neuronal-damage-induced-by-random-positioning-machine-exposure-in-differentiated-ht22-cells
#6
JOURNAL ARTICLE
Roberto Bonanni, Ida Cariati, Anna Maria Rinaldi, Mario Marini, Giovanna D'Arcangelo, Umberto Tarantino, Virginia Tancredi
Neuronal death could be responsible for the cognitive impairments found in astronauts exposed to spaceflight, highlighting the need to identify potential countermeasures to ensure neuronal health in microgravity conditions. Therefore, differentiated HT22 cells were exposed to simulated microgravity by random positioning machine (RPM) for 48 h, treating them with a single administration of Trolox, recombinant irisin (r-Irisin) or both. Particularly, we investigated cell viability by MTS assay, Trypan Blue staining and western blotting analysis for Akt and B-cell lymphoma 2 (Bcl-2), the intracellular increase of reactive oxygen species (ROS) by fluorescent probe and NADPH oxidase 4 (NOX4) expression, as well as the expression of brain-derived neurotrophic factor (BDNF), a major neurotrophin responsible for neurogenesis and synaptic plasticity...
2024: PloS One
https://read.qxmd.com/read/38511188/exercise-affects-high-fat-diet-stimulated-breast-cancer-metastasis-through-irisin-secretion-by-altering-cancer-stem-cell-properties
#7
JOURNAL ARTICLE
YuJin Lee, SoDam Park, SeungHwa Park, Hye Ji Kwon, Sang-Ho Lee, Yuri Kim, Jung-Hyun Kim
BACKGROUND: Regular physical activities reduce the growth of breast cancer, but research on the effects of steady exercise on metastasis and its mechanisms is limited. In this study, the effects of steady exercise on breast cancer metastasis and its possible mechanism were demonstrated. METHODS: Experimental metastasis was induced after 8 weeks of steady exercise using a mouse model. Furthermore, one of the myokines, irisin, was studied to elucidate the effects of metastasis-regulating protein expression, and colony and sphere formation, which are cancer stem cell properties...
July 2024: Biochemistry and Biophysics Reports
https://read.qxmd.com/read/38508115/maternal-prednisone-exposure-during-pregnancy-elevates-susceptibility-to-osteoporosis-in-female-offspring-the-role-of-mitophagy-fndc5-alteration-in-skeletal-muscle
#8
JOURNAL ARTICLE
Zun-Yu Du, Hua-Long Zhu, Wei Chang, Yu-Feng Zhang, Qing Ling, Kai-Wen Wang, Jin Zhang, Quan-Bing Zhang, Xiu-Li Kan, Qu-Nan Wang, Hua Wang, Yun Zhou
Maternal exposure to glucocorticoids has been associated with adverse outcomes in offspring. However, the consequences and mechanisms of gestational exposure to prednisone on susceptibility to osteoporosis in the offspring remain unclear. Here, we found that gestational prednisone exposure enhanced susceptibility to osteoporosis in adult mouse offspring. In a further exploration of myogenic mechanisms, results showed that gestational prednisone exposure down-regulated FNDC5/irisin protein expression and activation of OPTN-dependent mitophagy in skeletal muscle of adult offspring...
March 13, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38507777/greater-hyperthermia-in-men-with-type-2-diabetes-does-not-lead-to-higher-serum-levels-of-cellular-stress-biomarkers-following-exercise-heat-stress
#9
JOURNAL ARTICLE
Nicholas Goulet, Emily J Tetzlaff, James J McCormick, Kelli E King, Kristina-Marie T Janetos, Ronald J Sigal, Pierre Boulay, Glen P Kenny
Type 2 diabetes (T2D) is associated with worsening age-related impairments in heat loss, causing higher core temperature during exercise. We evaluated whether these thermoregulatory impairments occur with altered serum protein responses to heat stress by measuring cytoprotection, inflammation, and tissue damage biomarkers in middle-aged-to-older men (50-74 years) with (n=16) and without (n=14) T2D following exercise in 40°C. There were no changes in irisin, klotho, HSP70, sCD14, TNF-α, and IL-6, whereas NGAL (+539 pg/mL, p=0...
March 20, 2024: Applied Physiology Nutrition and Metabolism
https://read.qxmd.com/read/38502294/skeletal-muscle-derived-irisin-enhances-gemcitabine-sensitivity-and-suppresses-migration-ability-in-pancreatic-ductal-adenocarcinoma
#10
JOURNAL ARTICLE
Tomoki Sugimoto, Yoshifumi Iwagami, Shogo Kobayashi, Chihiro Yamanaka, Kazuki Sasaki, Daisaku Yamada, Yoshito Tomimaru, Tadafumi Asaoka, Takehiro Noda, Hidenori Takahashi, Junzo Shimizu, Yuichiro Doki, Hidetoshi Eguchi
BACKGROUND: High skeletal muscle mass might be a prognostic factor for patients with pancreatic ductal adenocarcinoma (PDAC); however, the underlying reason is unclear. We hypothesized that myokines, which are cytokines secreted by the skeletal muscle, function as suppressors of PDAC. We specifically examined irisin, a myokine, which plays a critical role in the modulation of metabolism, to clarify the anticancer mechanisms. METHODS: First, the effect of the conditioned medium (CM) from skeletal muscle cells and from irisin-knockdown skeletal muscle cells on PDAC cell lines was evaluated...
March 19, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38500346/-epicatechin-treatment-did-not-modify-the-thermogenic-pathway-in-the-gastrocnemius-muscle-of-male-rat-offspring-obeses-by-programming
#11
JOURNAL ARTICLE
María Elena Tejeda, Sergio De Los Santos, Ramón Mauricio Coral-Vázquez, Ana Álvarez-Chávez, Carlos Palma Flores, Elena Zambrano, Juan Pablo Méndez, Patricia Canto
The aim of this study was to analyse the expression of genes related to the regulation of energy metabolism in skeletal muscle tissue by comparing male offspring in two age groups [at 110 and 245 postnatal days (pnd)] from a mother with obesity induced by a high-fat diet and (-)-epicatechin (Epi) administration. Four groups of six male offspring from different litters were randomly selected for the control groups [C and offspring of mothers with maternal obesity (MO)] or Epi intervention groups. We evaluated the effect of Epi on gastrocnemius tissue by analysing the mRNA and protein expression levels of Fndc5/irisin, Pgc-1α, Ucp3, and Sln...
March 19, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38500202/mir-150-5p-inhibits-the-osteogenic-differentiation-of-bone-marrow-derived-mesenchymal-stem-cells-by-targeting-irisin-to-regulate-the-p38-mapk-signaling-pathway
#12
JOURNAL ARTICLE
Jia-Long Qi, Zhi-Dong Zhang, Zhou Dong, Tao Shan, Zong-Sheng Yin
PURPOSE: To study the effect of miR-150-5p on the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs), and further explore the relationship between its regulatory mechanism and irisin. METHODS: We isolated mouse BMSCs, and induced osteogenic differentiation by osteogenic induction medium. Using qPCR to detect the expression of osteogenic differentiation-related genes, western blot to detect the expression of osteogenic differentiation-related proteins, and luciferase reporter system to verify that FNDC5 is the target of miR-150-5p...
March 18, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38495793/editorial-changes-in-extracellular-matrix-associated-with-bone-disorders
#13
EDITORIAL
Caterina Licini, Xiao Lin
No abstract text is available yet for this article.
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38493812/irisin-delays-the-onset-of-type-1-diabetes-in-nod-mice-by-enhancing-intestinal-barrier
#14
JOURNAL ARTICLE
Yujing Sun, Yilin Wang, Ziang Lin, Fuhua Zhang, Yan Zhang, Tongxin Ren, LiNa Wang, Qincheng Qiao, Mengyang Shen, Juncheng Wang, Youchen Song, Yu Sun, Peng Lin
Type 1 diabetes (T1D), a complex autoimmune disease, is intricately linked to the gut's epithelial barrier function. Emerging evidence emphasizes the role of irisin, an exercise-related hormone, in preserving intestinal integrity. This study investigates whether irisin could delay T1D onset by enhancing the colon intestinal barrier. Impaired colon intestinal barriers were observed in newly diagnosed T1D patients and non-obese diabetic (NOD) mice, worsening with age and accompanied by islet inflammation. Using an LPS-induced colonic inflammation model, a dose-dependent impact of LPS on colon cells irisin expression, secretion, and barrier function was revealed...
March 15, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38482824/high-intensity-combination-exercise-has-the-highest-effect-on-increasing-serum-irisin-and-interleukin-6-levels-in-women-with-obesity
#15
JOURNAL ARTICLE
Uswatun Hasanah, Purwo Sri Rejeki, Citrawati Dyah Kencono Wungu, Adi Pranoto, Nabilah Izzatunnisa, Ilham Rahmanto, Shariff Halim
OBJECTIVES: Lifestyle, overnutrition, socioeconomic status, environmental conditions, and genetics are factors that cause obesity. Lifestyle modification with a nonpharmacological approach based on physical exercise is the starting point in overcoming obesity. However, physical exercise with the appropriate and effective intensity for obese subjects is still debated. Therefore, this study aims to prove the effect of intensity differences with aerobic-resistance combination exercise on increasing irisin and IL-6 levels in obese women...
March 15, 2024: Journal of Basic and Clinical Physiology and Pharmacology
https://read.qxmd.com/read/38474169/increased-circulating-irisin-levels-in-kidney-transplant-patients-is-there-a-connection-with-glycaemic-control
#16
JOURNAL ARTICLE
Beata Bzoma, Agnieszka Kuchta, Kornelia Sałaga-Zaleska, Aleksandra Krzesińska, Gabriela Chyła-Danił, Maciej Jankowski, Alicja Dębska-Ślizień
Irisin is a myokine with potential effects on glucose metabolism and the development of diabetes in humans. We analysed irisin serum levels (ISL) in 47 patients without diabetes before and 1, 2, 3, 4 and 5 weeks after kidney transplantation (KTx). All measurements of irisin before KTx levels were lower than 25 ng/mL (median 8.4 ng/mL). We found an outstanding increase in ISL measured after KTx, reaching more than 1000 times in 44% of patients (HIL-high irisin level group). The increase appeared at the first measurement (one week after KTx)...
March 2, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473094/myokines-produced-by-cultured-bovine-satellite-cells-harvested-from-3-and-11-month-old-angus-steers
#17
JOURNAL ARTICLE
Katie A Shira, Brenda M Murdoch, Kara J Thornton, Caleb C Reichhardt, Gabrielle M Becker, Gwinyai E Chibisa, Gordon K Murdoch
The myokines interleukin 6 (IL-6), interleukin 15 (IL-15), myonectin (CTRP15), fibronectin type III domain containing protein 5/irisin (FNDC5), and brain-derived neurotrophic factor (BDNF) are associated with skeletal muscle cell proliferation, differentiation, and muscle hypertrophy in biomedical model species. This study evaluated whether these myokines are produced by cultured bovine satellite cells (BSCs) harvested from 3- and 11-month-old commercial black Angus steers and if the expression and secretion of these targets change across 0, 12, 24, and 48 h in vitro...
February 24, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38463931/fndc5-genetic-polymorphism-in-patients-with-peripartum-cardiomyopathy
#18
JOURNAL ARTICLE
Ali Mohamad Altaher, Mohamed Eid, Hesham Moslem, Amal H Ali, Samar Mustafa, Amera Morad Foad
BACKGROUND: Late in pregnancy or soon after delivery, peripartum cardiomyopathy (PPCM) which is an uncommon type of cardiomyopathy, can develop. To assess the association between the level of irisin expression and (FNDC5) (rs3480) gene polymorphism with peripartum cardiomyopathy. METHODS: This is a case control study included a thirty female patients with new-onset PPCM and sixty healthy females at the at the peripartum period in same time window for PPCM as a control...
2024: Caspian Journal of Internal Medicine
https://read.qxmd.com/read/38454429/enhancing-cardiometabolic-health-unveiling-the-synergistic-effects-of-high-intensity-interval-training-with-spirulina-supplementation-on-selected-adipokines-insulin-resistance-and-anthropometric-indices-in-obese-males
#19
JOURNAL ARTICLE
Maryam Delfan, Ayoub Saeidi, Rashmi Supriya, Kurt A Escobar, Ismail Laher, Katie M Heinrich, Katja Weiss, Beat Knechtle, Hassane Zouhal
This study investigated the combined effects of 12 weeks of high-intensity interval training (HIIT) and spirulina supplementation on adipokine levels, insulin resistance, anthropometric indices, and cardiorespiratory fitness in 44 obese males (aged 25-40 years). The participants were randomly assigned to one of four groups: control (CG), supplement (SG), training (TG), or training plus supplement (TSG). The intervention involved daily administration of either spirulina or a placebo and HIIT three times a week for the training groups...
March 7, 2024: Nutrition & Metabolism
https://read.qxmd.com/read/38431555/the-impact-of-vitamin-d-on-type-2-diabetes-management-boosting-ptp1b-gene-expression-and-physical-activity-benefits-in-rats
#20
JOURNAL ARTICLE
Kimya Khaledi, Rastegar Hoseini, Ahmad Gharzi
BACKGROUND: The protein tyrosine phosphatase 1B (PTP1B) plays a crucial role in the development of insulin resistance. Aerobic training (AT) and vitamin D (Vit D) supplementation have been shown to individually improve glucose tolerance and diabetes-related factors. However, the impact of their combined effect on PTP1B gene expression and serum irisin in the visceral adipose tissue remains unknown. This study aims to investigate whether 8 weeks of combined AT with Vit D supplementation can improve the expression of PTP1B in adipose tissue and serum irisin in obese rats with type 2 diabetes (T2D)...
March 2, 2024: Genes & Nutrition
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