keyword
https://read.qxmd.com/read/38536548/bone-mineral-density-in-adults-growth-hormone-deficiency-with-different-ages-of-onset-a-real-world-retrospective-study
#1
JOURNAL ARTICLE
Hongbo Yang, Meiping Chen, Hanyuan Xu, Yunfeng Zhen, Yuelun Zhang, Linjie Wang, Lian Duan, Fengying Gong, Huijuan Zhu, Hui Pan
PURPOSE: Bone mineral density (BMD) impairment is one of the critical factors for long-term quality of life in adults growth hormone deficiency (AGHD). This study aims to investigate the annual changes in BMD in AGHD patients with different ages of onset and to identify predicting factors that influence BMD. METHODS: AGHD patients (n = 160) with available data for 4 years follow-up from a major tertiary medical center in China were retrospectively included (110 [68...
March 27, 2024: Endocrine
https://read.qxmd.com/read/38535998/targeting-mitochondrial-dysfunction-using-methylene-blue-or-mitoquinone-to-improve-skeletal-aging
#2
JOURNAL ARTICLE
Sher Bahadur Poudel, Dorra Frikha-Benayed, Ryan R Ruff, Gozde Yildirim, Manisha Dixit, Ron Korstanje, Laura Robinson, Richard A Miller, David E Harrison, John R Strong, Mitchell B Schaffler, Shoshana Yakar
Methylene blue (MB) is a well-established antioxidant that has been shown to improve mitochondrial function in both in vitro and in vivo settings. Mitoquinone (MitoQ) is a selective antioxidant that specifically targets mitochondria and effectively reduces the accumulation of reactive oxygen species. To investigate the effect of long-term administration of MB on skeletal morphology, we administered MB to aged (18 months old) female C57BL/J6 mice, as well as to adult male and female mice with a genetically diverse background (UM-HET3)...
March 25, 2024: Aging
https://read.qxmd.com/read/38535478/effect-of-ishige-okamurae-extract-on-osteoclastogenesis-in-vitro-and-in-vivo
#3
JOURNAL ARTICLE
Su-Hyeon Cho, Hyun-Soo Kim, Juhee Ahn, Bomi Ryu, Jun-Geon Jea, Kyubin Lee, Kyunghwan Kim, Ginnae Ahn, WonWoo Lee, Kyung-Min Choi, Kil-Nam Kim
We demonstrated the effect of Ishige okamurae extract (IOE) on the receptor activator of nuclear factor-κB ligand (RANKL)-promoted osteoclastogenesis in RAW 264.7 cells and confirmed that IOE inhibited RANKL-induced tartrate-resistant acid phosphatase (TRAP) activity and osteoclast differentiation. IOE inhibited protein expression of TRAP, metallopeptidase-9 (MMP-9), the calcitonin receptor (CTR), and cathepsin K (CTK). IOE treatment suppressed the expression of activated T cell cytoplasmic 1 and activator protein-1, thus controlling the expression of osteoclast-related factors...
March 20, 2024: Marine Drugs
https://read.qxmd.com/read/38534757/to-repair-a-broken-heart-stem-cells-in-ischemic-heart-disease
#4
REVIEW
Theodora M Stougiannou, Konstantinos C Christodoulou, Ioannis Dimarakis, Dimitrios Mikroulis, Dimos Karangelis
Despite improvements in contemporary medical and surgical therapies, cardiovascular disease (CVD) remains a significant cause of worldwide morbidity and mortality; more specifically, ischemic heart disease (IHD) may affect individuals as young as 20 years old. Typically managed with guideline-directed medical therapy, interventional or surgical methods, the incurred cardiomyocyte loss is not always completely reversible; however, recent research into various stem cell (SC) populations has highlighted their potential for the treatment and perhaps regeneration of injured cardiac tissue, either directly through cellular replacement or indirectly through local paracrine effects...
March 8, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534704/a-single-dose-of-piperacillin-plus-tazobactam-gel-as-an-adjunct-to-professional-mechanical-plaque-removal-pmpr-in-patients-with-peri-implant-mucositis-a-6-month-double-blind-randomized-clinical-trial
#5
JOURNAL ARTICLE
Ioana Ilyes, Marius Boariu, Darian Rusu, Vincenzo Iorio-Siciliano, Octavia Vela, Simina Boia, Georgios Kardaras, Petra Șurlin, Horia Calniceanu, Holger Jentsch, Alexandru Lodin, Stefan-Ioan Stratul
OBJECTIVES: This randomized, placebo-controlled, double-masked clinical trial aimed to evaluate the clinical and microbiological efficacy of professional mechanical plaque removal (PMPR) with or without adjunctive application of piperacillin plus tazobactam gel in the treatment of peri-implant mucositis (PiM) for up to 6 months. MATERIALS AND METHODS: The study included 31 patients with peri-implant mucositis (bleeding on probing (BoP) > 1 at at least one site at baseline, absence of peri-implant bone loss compared with a previous radiograph)...
March 17, 2024: Antibiotics
https://read.qxmd.com/read/38534546/a-one-year-randomized-controlled-clinical-trial-of-three-types-of-narrow-diameter-implants-for-fixed-partial-implant-supported-prosthesis-in-the-mandibular-incisor-area
#6
JOURNAL ARTICLE
Ji-Ho Ahn, Young-Jun Lim, Jungwon Lee, Yeon-Wha Baek, Myung-Joo Kim, Ho-Beom Kwon
Narrow-diameter implants (NDI) serve as a solution for treating limited bone volume in the anterior mandible. This study aimed to evaluate the one-year clinical outcomes of various NDIs in the mandibular incisor area after immediate loading in partially edentulous patients. This single-center, prospective, single-blinded, randomized controlled trial study included 21 patients, with 7 patients in each of the following groups: control (BLT NC SLActive® ; Straumann), experimental group 1 (CMI IS-III Active® S-Narrow; Neobiotech), and experimental group 2 (CMI IS-III Active® Narrow; Neobiotech)...
March 12, 2024: Bioengineering
https://read.qxmd.com/read/38534360/the-roles-of-fibrinolytic-factors-in-bone-destruction-caused-by-inflammation
#7
REVIEW
Yosuke Kanno
Chronic inflammatory diseases, such as rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, Crohn's disease, periodontitis, and carcinoma metastasis frequently result in bone destruction. Pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and IL-17 are known to influence bone loss by promoting the differentiation and activation of osteoclasts. Fibrinolytic factors, such as plasminogen (Plg), plasmin, urokinase-type plasminogen activator (uPA), its receptor (uPAR), tissue-type plasminogen activator (tPA), α2-antiplasmin (α2AP), and plasminogen activator inhibitor-1 (PAI-1) are expressed in osteoclasts and osteoblasts and are considered essential in maintaining bone homeostasis by regulating the functions of both osteoclasts and osteoblasts...
March 15, 2024: Cells
https://read.qxmd.com/read/38534304/the-long-term-esthetic-and-radiographic-outcome-of-implants-placed-in-the-anterior-maxilla-after-ridge-preservation-combining-bovine-xenograft-with-collagen-matrix
#8
JOURNAL ARTICLE
Leonidas Batas, Vithleem Xanthopoulou, Maria Gnigou, Triantafyllia Vagdouti, Ioannis Fragkioudakis, Ioannis Vouros
The objective of the study was to evaluate the long-term esthetic and radiographic results of implants placed in the anterior maxilla after ridge preservation, combining bovine xenograft with collagen matrix. Fifteen patients who required a single tooth extraction because of fracture, root resorption, or extended caries were included in the study. After extraction, all sites were grafted using Deproteinized Bovine Bone Mineral (DBBM) with collagen and covered by a resorbable collagen matrix (CM). Five months after socket grafting, implants were successfully installed...
March 20, 2024: Dentistry Journal
https://read.qxmd.com/read/38534298/multilevel-modeling-analysis-of-odontogenic-risk-factors-and-nasal-septum-deviation-associated-with-maxillary-sinus-mucosal-thickening-a-cone-beam-computed-tomography-study
#9
JOURNAL ARTICLE
Marwa Madi, Sara S Alsaad, Nada AlAssiry, Dina Attia, Mansour AlAssiry, Osama Zakaria
(1) Background: In this study, the impact of odontogenic risk factors with nasal septum deviation on maxillary sinus mucosal thickening was assessed using Cone-beam computed tomography CBCT. (2) Methods: A total of 328 maxillary sinus regions from 164 patients (85 males and 79 females) were examined. Images were interpreted by dental specialists and Otolaryngologists. Coronal and sagittal sections were examined to assess the proximity of the root tips of posterior maxillary teeth (RPMT) to the maxillary sinus...
March 13, 2024: Dentistry Journal
https://read.qxmd.com/read/38534297/the-accuracy-of-bone-assessment-distal-to-lower-second-molars-using-panoramic-radiography-a-systematic-review-and-meta-analysis
#10
REVIEW
Hassan Assiri, Albert Estrugo-Devesa, Xavier Roselló-Llabrés, Sonia Egido-Moreno, José López-López
Panoramic radiography (OPG) evaluates mandibular third molar impaction (MTMI). This systematic review aimed to investigate the diagnostic accuracy of OPG in detecting bone loss distal to the lower second molars. The associated bone loss with different impaction positions and the most prevalent positions of MTMI were investigated as secondary outcomes. In January 2023, PubMed, Scopus, and Cochrane were searched to identify studies published between January 2012 and January 2023. Two examiners blindly selected the eligible studies for data extraction and quality assessment...
March 11, 2024: Dentistry Journal
https://read.qxmd.com/read/38534183/what-factors-can-affect-the-occurrence-of-vertigo-in-patients-after-craniofacial-surgery-in-china
#11
JOURNAL ARTICLE
Sainan Zhang, Jun Zhuang, Wenhong Wu, Lan Huang, Mei Tian, Li Guo, Mengjin Sun, Jintian Hu, Na Liu
Vertigo is a complication of craniomaxillofacial contour plastic surgery characterized by dizziness from hypovolemia in the cerebral hemispheres and brainstem. The authors analyzed the current status and influencing factors of postoperative vertigo in patients who undergo craniomaxillofacial contouring and discussed improvements in nursing strategies. The authors investigated 418 patients admitted to the authors' hospital who underwent craniomaxillofacial contouring between November 2020 and October 2023 and divided them into asymptomatic and symptomatic groups based on syncopal precursors or vertigo...
March 27, 2024: Journal of Craniofacial Surgery
https://read.qxmd.com/read/38534175/the-association-between-craniofacial-fracture-patterns-and-traumatic-optic-neuropathy
#12
JOURNAL ARTICLE
Bashar Hassan, Joshua Yoon, Adekunle Elegbede, Shannath L Merbs, Fan Liang, Neil R Miller, Paul N Manson, Michael P Grant
Traumatic optic neuropathy (TON) is a rare but potentially devastating complication of craniofacial trauma. Approximately half of patients with TON sustain permanent vision loss. In this study, we sought to identify the most common fracture patterns associated with TON. We performed a retrospective review of craniomaxillofacial CT scans of trauma patients who presented to the R Adams Cowley Shock Trauma Center from 2015 to 2017. Included were adult patients who had orbital fractures with or without other facial fractures...
March 27, 2024: Journal of Craniofacial Surgery
https://read.qxmd.com/read/38534097/single-crown-restorations-supported-by-6-mm-implants-in-the-resorbed-posterior-mandible-a-10-year-prospective-case-series
#13
JOURNAL ARTICLE
Felix L Guljé, Gerry M Raghoebar, Barzi Gareb, Arjan Vissink, Henny J A Meijer
PURPOSE: To assess marginal bone level changes, implant and restoration survival, condition of the peri-implant mucosa, and the patient's satisfaction with the single restoration supported by a 6-mm long implant in the posterior mandible after 10 years in function. MATERIALS AND METHODS: Twenty-one consecutive patients missing premolars or molars in the posterior mandible, with a bone volume consisting of a width of at least 6 mm and an estimated height of 8 mm between the top of the ridge and alveolar nerve, were included...
March 27, 2024: Clinical Implant Dentistry and related Research
https://read.qxmd.com/read/38533771/head-and-neck-reconstruction-with-the-superficial-circumflex-iliac-artery-perforator-scip-free-flap-lessons-learned-after-73-cases
#14
JOURNAL ARTICLE
Mario F Scaglioni, Matteo Meroni, Patrick E Tomasetti, Gunesh P Rajan
BACKGROUND: Head and neck tissue defects after ablative surgery often require complex and composite reconstructions. The superficial circumflex iliac artery perforator (SCIP) flap is an extremely versatile perforator-based flap with minimal donor site morbidity, which may represent the optimal procedure in this setting. Over the last 5 years, we collected a large base of experience, including both simple and chimeric SCIP-based reconstruction, making this flap our first choice for head and neck reconstructions...
March 27, 2024: Head & Neck
https://read.qxmd.com/read/38533511/bones-on-fire-illuminating-osteomyelitis-through-the-radiant-lens-of-18-f-fdg-pet-ct
#15
REVIEW
Mei Yang, Quanhui Tan, Zhenghao Tang
Osteomyelitis is an inflammatory process that is caused by an infecting microorganism and leads to progressive bone destruction and loss. Osteomyelitis can occur at any age and can involve any bone. The infection can be limited to a single portion of the bone or can involve several regions, such as marrow, cortex, periosteum, and the surrounding soft tissue. Early and accurate diagnosis plays a crucial role in reducing unnecessary treatment measures, improving the patient's prognosis, and minimizing time and financial costs...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533346/detection-of-reduced-diameter-of-the-cochlear-nerve-in-long-term-deaf-patients-quantified-with-semiautomatic-measurement-of-nerve-cross-sectional-area-using-3t-mri-data
#16
JOURNAL ARTICLE
Katrin Reimann, Uwe Klose, Ulrike Ehrenpfordt, Kruthika Thangavelu, Maximilian Schulze
HYPOTHESIS: High-resolution parallel transmit T2 sampling perfection with application optimized contrast using different flip angle evolution sequence with improved edge discrimination and semiautomatic determination of nerve cross-sectional area (CSA) can be used to evaluate nerve degeneration in the inner auditory canal (IAC) in long-term deaf patients. BACKGROUND: In patients with hearing loss, temporal bone MRI is routinely acquired to evaluate the morphology of the nerves within the IAC...
March 2024: Otol Neurotol Open
https://read.qxmd.com/read/38533264/korean-red-ginseng-extract-prevents-bone-loss-in-an-oral-model-of-glucocorticoid-induced-osteoporosis-in-mice
#17
JOURNAL ARTICLE
Nicholas J Chargo, Ho Jun Kang, Subhashari Das, Yining Jin, Cheryl Rockwell, Jae Youl Cho, Laura R McCabe, Narayanan Parameswaran
The gut microbiota and barrier function play important roles in bone health. We previously demonstrated that chronic glucocorticoid (GC)-induced bone loss in mice is associated with significant shifts in gut microbiota composition and impaired gut barrier function. Korean Red Ginseng (KRG, Panax Ginseng Meyer, Araliaceae) extract has been shown to prevent glucocorticoid-induced osteoporosis (GIO) in a subcutaneous pellet model in mice, but its effect on gut microbiota and barrier function in this context is not known...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38533161/effectiveness-of-recent-physiotherapy-techniques-along-with-conventional-physiotherapy-techniques-in-a-patient-with-knee-osteoarthritis-a-case-report
#18
Kamya J Somaiya, Subrat Samal, Manali A Boob
Osteoarthritis (OA), the most common joint disease, lowers quality of life, restricts social activity participation, and results in incapacity. Osteoarthritis is characterised by changes in subchondral bone, meniscus degeneration, cartilage loss, and synovial inflammation. Physiotherapy plays a vital role in maintaining the stability of this disease. Various treatment approaches have been shown in numerous studies to be successful in improving the condition of individuals with osteoarthritis in the knee. We are presenting a case of a 47-year-old woman who had bilateral osteoarthritis in her knees...
February 2024: Curēus
https://read.qxmd.com/read/38533141/the-effect-of-tranexamic-acid-with-or-without-tourniquet-on-blood-loss-in-total-knee-arthroplasty-at-a-community-hospital
#19
JOURNAL ARTICLE
Elise N Ketelaar, Michael Wagner, Adam Lorenzo, Robert Comrie, Carolina Restini, Grace D Brannan, Roger Corvasce, Saad Mohammad
Tourniquets have long been used in total knee arthroplasty due to the theoretical improvement of bleeding control, integration of cement-bone interface, visibility, and efficiency of the overall surgery. However, this has become increasingly disputed. Comparative studies in total knee arthroplasty employing chemical prophylaxis, i.e., tranexamic acid, have been conducted. This retrospective cohort study evaluated the effect of tranexamic with or without a tourniquet on mean blood loss, hemoglobin, and length of stay in total knee arthroplasty patients...
February 2024: Curēus
https://read.qxmd.com/read/38532664/bone-health-and-the-masters-runner
#20
REVIEW
Sara N Raiser, Allison N Schroeder, Richard J Lawley, Adam S Tenforde
Masters runners are often defined as those ages 35 years and older who train and compete in running events. These runners represent a growing population of the overall running community and experience running-related injuries including bone stress injuries (BSIs). Similar to younger runners, health considerations in masters runners include the goal to optimize bone health with focus on mitigating age-associated loss of bone strength and preventing BSIs through a combination of ensuring appropriate physical activity, optimizing nutrition, and correcting faulty biomechanics...
March 27, 2024: PM & R: the Journal of Injury, Function, and Rehabilitation
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