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Research; monitoring & evaluation

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https://www.readbyqxmd.com/read/28725586/role-of-prostate-magnetic-resonance-imaging-in-active-surveillance
#1
REVIEW
Xiaosong Meng, Andrew B Rosenkrantz, Samir S Taneja
Active surveillance (AS) has emerged as a beneficial strategy for management of low risk prostate cancer (PCa) and prevention of overtreatment of indolent disease. However, selection of patients for AS using traditional 12-core transrectal prostate biopsy is prone to sampling error and presents a challenge for accurate risk stratification. In fact, around a third of men are upgraded on repeat biopsy which disqualifies them as appropriate AS candidates. This uncertainty affects adoption of AS among patients and physicians, leading to current AS protocols involving repetitive prostate biopsies and unclear triggers for progression to definitive treatment...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28721086/adaptation-to-illness-in-relation-to-pain-perceived-by-patients-after-surgery
#2
Mariusz Chabowski, Michał Junke, Jan Juzwiszyn, Magdalena Milan, Maciej Malinowski, Dariusz Janczak
BACKGROUND: Pain is one of the factors that decrease quality of life. Undergoing surgery is inevitably associated with the sensation of pain, which can affect a patient's level of acceptance of an illness. The aim of the study was to evaluate the level of acceptance of illness in patients undergoing surgical treatment with relation to the pain perceived by them during surgical treatment and to determine other factors that affect adaptation to illness among patients subjected to invasive treatment...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28720617/protocol-for-an-online-randomised-controlled-trial-to-evaluate-the-clinical-and-cost-effectiveness-of-a-peer-supported-self-management-intervention-for-relatives-of-people-with-psychosis-or-bipolar-disorder-relatives-education-and-coping-toolkit-react
#3
Fiona Lobban, Heather Robinson, Duncan Appelbe, Johanna Barraclough, Emma Bedson, Lizzie Collinge, Susanna Dodd, Sue Flowers, Mahsa Honary, Sonia Johnson, Ceu Mateus, Barbara Mezes, Valerie Minns, Elizabeth Murray, Andrew Walker, Paula Williamson, Catherine Wintermeyer, Steven Jones
INTRODUCTION: Despite clinical guidelines recommendations, many relatives of people with psychosis or bipolar disorder do not currently receive the support they need. Online information and support may offer a solution. METHODS AND ANALYSIS: This single-blind, parallel, online randomised controlled trial will determine clinical and cost-effectiveness of the Relatives Education And Coping Toolkit (REACT) (including an online resource directory (RD)), compared with RD only, for relatives of people with psychosis or bipolar disorder...
July 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28720227/co-creative-development-of-an-ehealth-nursing-intervention-self-management-support-for-outpatients-with-cancer-pain
#4
Laura M J Hochstenbach, Annemie M Courtens, Sandra M G Zwakhalen, Joan Vermeulen, Maarten van Kleef, Luc P de Witte
INTRODUCTION: Co-creative methods, having an iterative character and including different perspectives, allow for the development of complex nursing interventions. Information about the development process is essential in providing justification for the ultimate intervention and crucial in interpreting the outcomes of subsequent evaluations. This paper describes a co-creative method directed towards the development of an eHealth intervention delivered by registered nurses to support self-management in outpatients with cancer pain...
August 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28720103/an-information-and-communication-technology-based-centralized-clinical-trial-to-determine-the-efficacy-and-safety-of-insulin-dose-adjustment-education-based-on-a-smartphone-personal-health-record-application-a-randomized-controlled-trial
#5
Gyuri Kim, Ji Cheol Bae, Byoung Kee Yi, Kyu Yeon Hur, Dong Kyung Chang, Moon-Kyu Lee, Jae Hyeon Kim, Sang-Man Jin
BACKGROUND: A Personal Health Record (PHR) is an online application that allows patients to access, manage, and share their health data. PHRs not only enhance shared decision making with healthcare providers, but also enable remote monitoring and at-home-collection of detailed data. The benefits of PHRs can be maximized in insulin dose adjustment for patients starting or intensifying insulin regimens, as frequent self-monitoring of glucose, self-adjustment of insulin dose, and precise at-home data collection during the visit-to-visit period are important for glycemic control...
July 18, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28718260/cerebral-oximetry-use-for-cardiac-surgery
#6
Syed Shahmeer Raza, Farhan Ullah, Chandni, Edward Bruce Savage
BACKGROUND: Studies have shown maintaining good cerebral perfusion during Cardiac Surgeries is very important in terms of patient outcomes and reducing the hospital stay, which may have its financial and clinical implications. The aim of this review study was to determine the effectiveness of Cerebral Oximetry (Transcranial Near-Infrared Spectroscopy-NIRS to monitor cerebral oxygenation) for Cardiac Surgery and to propose a possible concluding remark about its potential applications, overall clinical value and whether to keep using it or not...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28717897/development-of-a-fast-and-cost-effective-gas-chromatography-mass-spectrometry-method-for-the-quantification-of-short-chain-and-medium-chain-fatty-acids-in-human-biofluids
#7
Cesare Lotti, Josep Rubert, Francesca Fava, Kieran Tuohy, Fulvio Mattivi, Urska Vrhovsek
The quantification of short-chain and medium-chain fatty acids is becoming more and more relevant in fecal and plasma samples due to their biological impact, which has been associated with colon rectal cancer and fiber consumption. For these reasons, a fast, cost-effective, and reproducible analytical method is highly required. In this research, a gas chromatography-mass spectrometry method based on full scan and multiple reaction monitoring (MRM) acquisition modes were optimized and validated for the analysis of short-chain and medium-chain fatty acids in three biological samples: human fecal water, fecal fermentation supernatants, and human plasma...
July 17, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28715482/impact-of-maternal-body-mass-index-and-gestational-weight-gain-on-neonatal-outcomes-among-healthy-middle-eastern-females
#8
Tatiana Papazian, Georges Abi Tayeh, Darine Sibai, Hala Hout, Imad Melki, Lydia Rabbaa Khabbaz
BACKGROUND: Studies on the relative impact of body mass index in women in childbearing age and gestational weight gain on neonatal outcomes are scarce in the Middle East. OBJECTIVES: The primary objective of this research was to assess the impact of maternal body mass index (BMI) and gestational weight gain (GWG) on neonatal outcomes. The effect of maternal age and folic acid supplementation before and during pregnancy was also examined. SUBJECTS AND METHODS: This is a retrospective cross sectional observational study of 1000 full term deliveries of women enrolled thru the National Collaborative Perinatal Neonatal Network, in Lebanon...
2017: PloS One
https://www.readbyqxmd.com/read/28715350/a-prospective-multisite-international-validation-of-the-complex-regional-pain-syndrome-severity-score
#9
R Norman Harden, Christian Maihofner, Elias Abousaad, Jean-Jacques Vatine, Amy Kirsling, Roberto S G M Perez, Maxine Kuroda, Florian Brunner, Michael Stanton-Hicks, Johan Marinus, Jacobus J van Hilten, Sean Mackey, Frank Birklein, Tanja Schlereth, Angela Mailis-Gagnon, Joe Graciosa, Sara B Connoly, David Dayanim, Michael Massey, Hadas Frank, Anatoly Livshitz, Stephen Bruehl
Clinical diagnosis of complex regional pain syndrome (CRPS) is a dichotomous (yes/no) categorization, a format necessary for clinical decision making. Such dichotomous diagnostic categories do not convey an individual's subtle gradations in the severity of the condition over time and have poor statistical power when used as an outcome measure in research. This prospective, international, multicenter study slightly modified and further evaluated the validity of the CRPS Severity Score (CSS), a continuous index of CRPS severity...
August 2017: Pain
https://www.readbyqxmd.com/read/28714272/fluorescence-spectroscopy-coupled-with-independent-components-analysis-to-monitor-molecular-changes-during-heating-and-cooling-of-cantal-type-cheeses-with-different-nacl-and-kcl-contents
#10
Mohammed Loudiyi, Romdhane Karoui, Douglas N Rutledge, Marie-Christine Montel, Etienne Rifa, Abderrahmane Aït-Kaddour
BACKGROUND: Reduction of NaCl content of cheeses has received considerable attention by researches during the past decades due to its health effects. Nonetheless, NaCl reduction is a challenge since it plays an important role in cheese quality, such as structure, texture and functional properties. Serval methods were used to evaluate the effect of NaCl on these attributes. In this study, Cantal-type cheeses with different salts (NaCl and KCl) were analyzed for their structure at a molecular level and rheological properties during heating (20 to 60 °C) and cooling (60 to 20 °C)...
July 17, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28711891/-strategic-patient-safety-action-plan-for-the-anesthesiology-and-intensive-care-service-of-ukraine-basic-modules-and-their-components
#11
Роман Н Федосюк
INTRODUCTION: In recent years, the problem of patient safety has become top-priority in further improvement of national healthcare systems in all developed countries. AIM: To develop a modular structure and a component composition of the strategic patient safety action plan for the anesthesiology and intensive care service of Ukraine as a part of the National Action Plan. MATERIALS AND METHODS: Major domestic priorities, substantiated and made public by the author in previous works, are taken as the basis for the modular structuring of the action plan...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28711738/phase-properties-of-transcranial-electrical-stimulation-artifacts-in-electrophysiological-recordings
#12
Nima Noury, Markus Siegel
Monitoring brain activity during transcranial electric stimulation (tES) is an attractive approach for causally studying healthy and diseased brain activity. Yet, stimulation artifacts complicate electrophysiological recordings during tES. Design and evaluation of artifact removal methods require a through characterization of artifact features, i.e. characterization of the transfer function that defines the relationship between the tES stimulation current and tES artifacts. Here we characterize the phase relationship between stimulation current and tES artifacts in EEG and MEG...
July 12, 2017: NeuroImage
https://www.readbyqxmd.com/read/28711296/anaerobic-digestion-of-food-waste-a-review-focusing-on-process-stability
#13
REVIEW
Lei Li, Xuya Peng, Xiaoming Wang, Di Wu
Food waste (FW) is rich in biomass energy, and increasing numbers of national programs are being established to recover energy from FW using anaerobic digestion (AD). However process instability is a common operational issue for AD of FW. Process monitoring and control as well as microbial management can be used to control instability and increase the energy conversion efficiency of anaerobic digesters. Here, we review research progress related to these methods and identify existing limitations to efficient AD; recommendations for future research are also discussed...
July 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28710666/mediators-of-physical-activity-adherence-results-from-an-action-control-intervention-in-couples
#14
Corina Berli, Gertraud Stadler, Patrick E Shrout, Niall Bolger, Urte Scholz
BACKGROUND: Behavior change interventions targeting self-regulation skills have generally shown promising effects. However, the psychological working mechanisms remain poorly understood. PURPOSE: We examined theory-based mediators of a randomized controlled trial in couples targeting action control (i.e., continuously monitoring and evaluating an ongoing behavior). Self-reported action control was tested as the main mediating mechanism of physical activity adherence, and in addition self-efficacy and received social support from the partner...
July 14, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28710065/the-limitations-of-using-randomised-controlled-trials-as-a-basis-for-developing-treatment-guidelines
#15
REVIEW
Roger Mulder, Ajeet B Singh, Amber Hamilton, Pritha Das, Tim Outhred, Grace Morris, Darryl Bassett, Bernhard T Baune, Michael Berk, Philip Boyce, Bill Lyndon, Gordon Parker, Gin S Malhi
Randomised controlled trials (RCTs) are considered the 'gold standard' by which novel psychotropic medications and psychological interventions are evaluated and consequently adopted into widespread clinical practice. However, there are some limitations to using RCTs as the basis for developing treatment guidelines. While RCTs allow researchers to determine whether a given medication or intervention is effective in a specific patient sample, for practicing clinicians it is more important to know whether it will work for their particular patient in their particular setting...
July 14, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/28708093/real-time-communication-support-for-underwater-acoustic-sensor-networks-%C3%A2
#16
Rodrigo Santos, Javier Orozco, Matias Micheletto, Sergio F Ochoa, Roc Meseguer, Pere Millan, And Carlos Molina
Underwater sensor networks represent an important and promising field of research due to the large diversity of underwater ubiquitous applications that can be supported by these networks, e.g., systems that deliver tsunami and oil spill warnings, or monitor submarine ecosystems. Most of these monitoring and warning systems require real-time communication in wide area networks that have a low density of nodes. The underwater communication medium involved in these networks is very harsh and imposes strong restrictions to the communication process...
July 14, 2017: Sensors
https://www.readbyqxmd.com/read/28706772/dorsal-skinfold-chamber-models-in-mice
#17
Jeannine Schreiter, Sophia Meyer, Christian Schmidt, Ronny M Schulz, Stefan Langer
Background/purpose: The use of dorsal skinfold chamber models has substantially improved the understanding of micro-vascularisation in pathophysiology over the last eight decades. It allows in vivo pathophysiological studies of vascularisation over a continuous period of time. The dorsal skinfold chamber is an attractive technique for monitoring the vascularisation of autologous or allogenic transplants, wound healing, tumorigenesis and compatibility of biomaterial implants. To further reduce the animals' discomfort while carrying the dorsal skinfold chamber, we developed a smaller chamber (the Leipzig Dorsal Skinfold Chamber) and summarized the commercial available chamber models...
2017: GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
https://www.readbyqxmd.com/read/28706322/respirable-dust-measured-downwind-during-rock-dust-application
#18
M L Harris, J Organiscak, S Klima, I E Perera
The Pittsburgh Mining Research Division of the U.S. National Institute for Occupational Safety and Health (NIOSH) conducted underground evaluations in an attempt to quantify respirable rock dust generation when using untreated rock dust and rock dust treated with an anticaking additive. Using personal dust monitors, these evaluations measured respirable rock dust levels arising from a flinger-type application of rock dust on rib and roof surfaces. Rock dust with a majority of the respirable component removed was also applied in NIOSH's Bruceton Experimental Mine using a bantam duster...
May 2017: Mining Engineering
https://www.readbyqxmd.com/read/28706104/use-of-a-mobile-social-networking-intervention-for-weight-management-a-mixed-methods-study-protocol
#19
Liliana Laranjo, Annie Y S Lau, Paige Martin, Huong Ly Tong, Enrico Coiera
INTRODUCTION: Obesity and physical inactivity are major societal challenges and significant contributors to the global burden of disease and healthcare costs. Information and communication technologies are increasingly being used in interventions to promote behaviour change in diet and physical activity. In particular, social networking platforms seem promising for the delivery of weight control interventions.We intend to pilot test an intervention involving the use of a social networking mobile application and tracking devices (Fitbit Flex 2 and Fitbit Aria scale) to promote the social comparison of weight and physical activity, in order to evaluate whether mechanisms of social influence lead to changes in those outcomes over the course of the study...
July 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28706084/rationale-and-protocol-for-the-after-diabetes-diagnosis-research-support-system-address-an-incident-and-high-risk-type-1-diabetes-uk-cohort-study
#20
Helen C Walkey, Akaal Kaur, Vassiliki Bravis, Ian F Godsland, Shivani Misra, Alistair J K Williams, Polly J Bingley, David B Dunger, Nick Oliver, Desmond G Johnston
INTRODUCTION: Type 1 diabetes is heterogeneous in its presentation and progression. Variations in clinical presentation between children and adults, and with ethnic group warrant further study in the UK to improve understanding of this heterogeneity. Early interventions to limit beta cell damage in type 1 diabetes are undergoing evaluation, but recruitment is challenging. The protocol presented describes recruitment of people with clinician-assigned, new-onset type 1 diabetes to understand the variation in their manner of clinical presentation, to facilitate recruitment into intervention studies and to create an open-access resource of data and biological samples for future type 1 diabetes research...
July 12, 2017: BMJ Open
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