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Research; monitoring & evaluation

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https://www.readbyqxmd.com/read/28109965/a-novel-acidic-ph-fluorescent-probe-based-on-a-benzothiazole-derivative
#1
Qiujuan Ma, Xian Li, Suxiang Feng, Beibei Liang, Tiqiang Zhou, Min Xu, Zhuoyi Ma
A novel acidic pH fluorescent probe 1 based on a benzothiazole derivative has been designed, synthesized and developed. The linear response range covers the acidic pH range from 3.44 to 6.46, which is valuable for pH researches in acidic environment. The evaluated pKa value of the probe 1 is 4.23. The fluorescence enhancement of the studied probe 1 with an increase in hydrogen ions concentration is based on the hindering of enhanced photo-induced electron transfer (PET) process. Moreover, the pH sensor possesses a highly selective response to H(+) in the presence of metal ions, anions and other bioactive small molecules which would be interfere with its fluorescent pH response...
January 12, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28109406/salivary-biomarkers-in-the-diagnosis-of-breast-cancer-a-review
#2
REVIEW
Elisa Cançado Porto-Mascarenhas, Daniele Xavier Assad, Hélène Chardin, David Gozal, Graziela De Luca Canto, Ana Carolina Acevedo, Eliete Neves Silva Guerra
Salivary biomarkers could be helpful to characterize breast cancer. Therefore, this review was performed to evaluate the capability of salivary biological markers in the diagnosis and monitoring of breast cancer. Studies were eligible for inclusion if they assessed the potential diagnostic value or other discriminatory properties of biological markers in saliva of patients with breast cancer. The search was performed in six electronic databases (Cochrane, LILACS, PubMed, Science Direct, Scopus, Web of Science)...
February 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28109192/prevalence-of-oral-manifestations-in-children-and-adolescents-with-cancer-submitted-to-chemotherapy
#3
Deise Berger Velten, Eliana Zandonade, Maria Helena Monteiro de Barros Miotto
BACKGROUND: Oral complications may be observed during chemotherapy and are important side effects that may directly affect the anticancer treatment, even causing septicaemia in some cases. This research was done in order to evaluate changes in oral lesions during follow-up of children and adolescents in chemotherapy at Hospital Estadual Infantil Nossa Senhora da Glória (HEINSG). METHODS: The study design was longitudinal, 45 patients were evaluated and monitored for 1 month after the initiation of chemotherapy...
January 20, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28108095/indoor-temperature-and-humidity-in-new-york-city-apartments-during-winter
#4
Ashlinn Quinn, Jeffrey Shaman
BACKGROUND: Concerns about indoor residential humidity have largely centered on dampness prevention. Overly dry air, however, may favor the survival of some viruses and hence respiratory infections. Many residents employ portable humidifiers to humidify their home environment, yet the effect of these humidifiers on indoor humidity is not known. METHODS: We monitored indoor temperature and humidity in 34 apartments in New York City during winter 2014-2015. We combined information from the monitors with surveyed information on building, household, and apartment-level factors and with information on household humidifier use...
January 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28107923/a-sensitive-and-rapid-uflc-apci-ms-ms-bioanalytical-method-for-quantification-of-endogenous-and-exogenous-vitamin-k1-isomers-in-human-plasma-development-validation-and-first-application-to-a-pharmacokinetic-study
#5
Nagaraj Kumar Nannapaneni, Sunil S Jalalpure, Rajendraprasad Muppavarapu, Sunil Kumar Sirigiri
Due to lack of suitable bioanalytical methods in previous literature, for simultaneous estimation of Vitamin K1 isomers, in compliance with the current regulatory expectation, we aimed to develop a sensitive and rapid method with UFLC-APCI-MS/MS (ultrafast liquid chromatography - tandem mass spectrometry) using human plasma. A simple and cost effective procedure was implemented with the combination of protein precipitation and liquid extraction, to isolate the targets from plasma sample, while achieving an insignificant matrix effects and high recovery (≥88...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28105877/academic-detailing-among-psychiatrists-feasibility-and-acceptability
#6
Kamini Vasudev, Joel Lamoure, Michael Beyaert, Varinder Dua, David Dixon, Jason Eadie, Larissa Husarewych, Ragu Dhir, Jatinder Takhar
Purpose Research has shown that academic detailing (AD), which includes repeated in-person educational messages in an interactive format in a physician's office, is among the most effective continuing medical education (CME) forms for improving prescribing practices and reducing drug costs. The purpose of this paper is to investigate AD's feasibility and acceptability as an educational tool among psychiatrists and its ability to facilitate positive changes in antipsychotic prescribing. Design/methodology/approach All psychiatrists practicing in Southwestern Ontario, Canada were invited to participate...
February 13, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28105593/monitoring-pharmaceuticals-and-personal-care-products-in-reservoir-water-used-for-drinking-water-supply
#7
Carolina Aristizabal-Ciro, Ana María Botero-Coy, Francisco J López, Gustavo A Peñuela
In this work, the presence of selected emerging contaminants has been investigated in two reservoirs, La Fe (LF) and Rio Grande (RG), which supply water to two drinking water treatment plants (DWTPs) of Medellin, one of the most populated cities of Colombia. An analytical method based on solid-phase extraction (SPE) of the sample followed by measurement by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) was developed and validated for this purpose. Five monitoring campaigns were performed in each reservoir, collecting samples from 7 sites (LF) and 10 sites (RG) at 3 different depths of the water column...
January 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28100976/ventricular-tachycardia-in-fabry-disease-detected-in-a-50-year-old-woman-during-14-day-continuous-cardiac-monitoring
#8
Jaime Silva-Gburek, Laura Rochford, Robert Hopkin, John L Jefferies
Fabry disease is an X-linked lysosomal storage disorder. Female carriers were long thought to be asymptomatic; however, research has revealed the opposite. Cardiac conditions are the chief causes of death in women with Fabry disease. Although ventricular tachycardia has been reported in male patients with Fabry disease, it is not thought to be a frequent finding in females. We describe the case of a 50-year-old woman in whom we used 14-day continuous electrocardiographic monitoring to identify nonsustained ventricular tachycardia, after electrocardiograms and 24-hour Holter monitoring failed to detect the arrhythmia...
December 2016: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/28100291/systematic-review-of-neuropsychological-rehabilitation-for-prospective-memory-deficits-as-a-consequence-of-acquired-brain-injury
#9
Steven Mahan, Rebecca Rous, Anna Adlam
OBJECTIVES: Prospective memory (PM) impairments are common following acquired brain injury (ABI). PM is the ability to keep a goal in mind for future action and interventions have the potential to increase independence. This review aimed to evaluate studies examining PM rehabilitation approaches in adults and children with ABI. METHODS: Relevant literature was identified using PsycARTICLES (1894 to present), PsycINFO (1880 to present), the Cochrane Library (1972 to present), MEDLINE PubMed, reference lists from relevant journal articles, and searches of key journals...
January 19, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28099453/elimination-of-porcine-epidemic-diarrhea-virus-in-an-animal-feed-manufacturing-facility
#10
Anne R Huss, Loni L Schumacher, Roger A Cochrane, Elizabeth Poulsen, Jianfa Bai, Jason C Woodworth, Steve S Dritz, Charles R Stark, Cassandra K Jones
Porcine Epidemic Diarrhea Virus (PEDV) was the first virus of wide scale concern to be linked to possible transmission by livestock feed or ingredients. Measures to exclude pathogens, prevent cross-contamination, and actively reduce the pathogenic load of feed and ingredients are being developed. However, research thus far has focused on the role of chemicals or thermal treatment to reduce the RNA in the actual feedstuffs, and has not addressed potential residual contamination within the manufacturing facility that may lead to continuous contamination of finished feeds...
2017: PloS One
https://www.readbyqxmd.com/read/28099422/relationship-between-perfusion-index-and-patent-ductus-arteriosus-in-preterm-infants
#11
Enrique Gomez-Pomar, Majd Makhoul, Philip M Westgate, Katrina T Ibonia, Abhijit Patwardhan, Peter J Giannone, Henrietta Bada, Elie G Abu Jawdeh
BACKGROUND: Perfusion index (PI) is a noninvasive measure of perfusion. ΔPI (difference between pre and post-ductal PI) may identify hemodynamically significant PDA. However, studies are limited to brief and intermittent ΔPI sampling. Our objective is to assess the value of continuous high resolution ΔPI monitoring in the diagnosis of PDA. METHODS: Continuous ΔPI monitoring in preterm infants was prospectively performed using two high resolution pulse oximeters...
January 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28098831/a-fast-multimodal-ectopic-beat-detection-method-applied-for-blood-pressure-estimation-based-on-pulse-wave-velocity-measurements-in-wearable-sensors
#12
Maik Pflugradt, Kai Geissdoerfer, Matthias Goernig, Reinhold Orglmeister
Automatic detection of ectopic beats has become a thoroughly researched topic, with literature providing manifold proposals typically incorporating morphological analysis of the electrocardiogram (ECG). Although being well understood, its utilization is often neglected, especially in practical monitoring situations like online evaluation of signals acquired in wearable sensors. Continuous blood pressure estimation based on pulse wave velocity considerations is a prominent example, which depends on careful fiducial point extraction and is therefore seriously affected during periods of increased occurring extrasystoles...
January 14, 2017: Sensors
https://www.readbyqxmd.com/read/28096008/the-effect-of-progressive-muscle-relaxation-on-glycated-hemoglobin-and-health-related-quality-of-life-in-patients-with-type-2-diabetes-mellitus
#13
Tahereh Najafi Ghezeljeh, Maryam Kohandany, Fateme Hagdoost Oskouei, Mojtaba Malek
AIM: This study aimed to evaluate the effect of Jacobson's progressive muscle relaxation (PMR) on glycated hemoglobin (HbA1c) levels and health-related quality of life (HRQoL) in patients with type 2 diabetes mellitus (DM). BACKGROUND: Due to relatively poor HRQoL in patients with type 2 DM, different stress reduction techniques was applied to improve physical and mental health in these patients. METHODS: This randomized controlled clinical trial was conducted at the Diabetes and Endocrinology Institute of Firoozgar Hospital, Tehran, Iran, between June and December 2015...
February 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28095211/social-networking-in-an-agricultural-research-center-using-data-to-enhance-outcomes
#14
Mary E Cramer, Ozgur M Araz, Mary J Wendl
The purpose of this article is to present a case study of one Midwestern Agricultural Center that used social network analysis (SNA) to 1) evaluate its collaborations with extramural stakeholders and 2) strategically plan for extending outreach for goal achievement. An evaluation team developed a data collection instrument based on SNA principles. It was administered to the Agricultural Center's intramural stakeholders (N = 9), who were asked to identify the key extramural stakeholders with whom they had collaborated within the previous 12 months...
January 17, 2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28092624/changes-in-reticulorumen-content-temperature-and-ph-according-to-time-of-day-and-yearly-seasons
#15
R Antanaitis, V Žilaitis, V Juozaitienė, R Stoškus, M Televičius
The monitoring of rumen content temperature can be useful for the evaluation of cow health condition and heat. The aim of this research was to evaluate the influence of the circadian rhythm (time of day) and season on reticulorumen acidity (pH) and temperatures (RT) in lactating dairy cows. The research was performed on ten 2nd - lactation, clinically healthy Lithuanian Black and White fresh dairy cows (up to 1 day after calving). The cows were milked twice daily at 05:00 and 17:00. The cows were kept in a loose housing system, and were fed a feed ration throughout the year at the same time, balanced according to their physiological needs...
December 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28092053/sh2-domain-based-fret-biosensor-for-measuring-bcr-abl-activity-in-living-cml-cells
#16
Mari Fujioka, Yumi Asano, Shigeyuki Nakada, Yusuke Ohba
Fluorescent proteins (FPs) displaying distinct spectra have shed their light on a wide range of biological functions. Moreover, sophisticated biosensors engineered to contain single or multiple FPs, including Förster resonance energy transfer (FRET)-based biosensors, spatiotemporally reveal the molecular mechanisms underlying a variety of pathophysiological processes. However, their usefulness for applied life sciences has yet to be fully explored. Recently, our research group has begun to expand the potential of FPs from basic biological research to the clinic...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28091883/ground-penetrating-radar-gpr-responses-for-sub-surface-salt-contamination-and-solid-waste-modeling-and-controlled-lysimeter-studies
#17
Y N S Wijewardana, A T Shilpadi, M I M Mowjood, K Kawamoto, L W Galagedara
The assessment of polluted areas and municipal solid waste (MSW) sites using non-destructive geophysical methods is timely and much needed in the field of environmental monitoring and management. The objectives of this study are (i) to evaluate the ground-penetrating radar (GPR) wave responses as a result of different electrical conductivity (EC) in groundwater and (ii) to conduct MSW stratification using a controlled lysimeter and modeling approach. A GPR wave simulation was carried out using GprMax2D software, and the field test was done on two lysimeters that were filled with sand (Lysimeter-1) and MSW (Lysimeter-2)...
February 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28090668/studies-of-anticancer-drug-cytotoxicity-based-on-long-term-hepg2-spheroid-culture-in-a-microfluidic-system
#18
Agnieszka Zuchowska, Karina Kwapiszewska, Michal Chudy, Artur Dybko, Zbigniew Brzozka
Cell-on-a-chip systems have become promising devices to study the effectiveness of new anticancer drugs recently. Several microdevices for liver cancer culture and evaluation of the drug cytotoxicity have been reported. However, there are still no proven reports about high-throughput and simple methods for the evaluation of drug cytotoxicity on liver cancer cells. The paper presents the results of the effects of the anticancer drug (5-fluorouracil, 5-FU) on the HepG2 spheroids as a model of liver cancer. The experiments were based on the long-term 3D spheroid culture in the microfluidic system and monitoring of the effect of 5-FU at two selected concentrations (0...
January 16, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28089967/clinical-orofacial-examination-in-juvenile-idiopathic-arthritis-international-consensus-based-recommendations-for-monitoring-patients-in-clinical-practice-and-research-studies
#19
Peter Stoustrup, Marinka Twilt, Lynn Spiegel, Kasper Dahl Kristensen, Bernd Koos, Thomas Klit Pedersen, Annelise Küseler, Randy Q Cron, Shelly Abramowicz, Carlalberta Verna, Timo Peltomäki, Per Alstergren, Ross Petty, Sarah Ringold, Sven Erik Nørholt, Rotraud K Saurenmann, Troels Herlin
OBJECTIVE: To develop international consensus-based recommendations for the orofacial examination of patients with juvenile idiopathic arthritis (JIA), for use in clinical practice and research. METHODS: Using a sequential phased approach, a multidisciplinary task force developed and evaluated a set of recommendations for the orofacial examination of patients with JIA. Phase 1: A Delphi survey was conducted among 40 expert physicians and dentists with the aim of identifying and ranking the importance of items for inclusion...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28089416/strategies-to-overcome-therapeutic-resistance-in-renal-cell-carcinoma
#20
REVIEW
Peter J Siska, Kathryn E Beckermann, W Kimryn Rathmell, Scott M Haake
BACKGROUND: Renal cell cancer (RCC) is a prevalent and lethal disease. At time of diagnosis, most patients present with localized disease. For these patients, the standard of care includes nephrectomy with close monitoring thereafter. While many patients will be cured, 5-year recurrence rates range from 30% to 60%. Furthermore, nearly one-third of patients present with metastatic disease at time of diagnosis. Metastatic disease is rarely curable and typically lethal. Cytotoxic chemotherapy and radiation alone are incapable of controlling the disease...
January 11, 2017: Urologic Oncology
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