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https://www.readbyqxmd.com/read/28927264/comparative-interactomes-of-vrk1-and-vrk3-with-their-distinct-roles-in-the-cell-cycle-of-liver-cancer
#1
Namgyu Lee, Dae-Kyum Kim, Seung Hyun Han, Hye Guk Ryu, Sung Jin Park, Kyong-Tai Kim, Kwan Yong Choi
Vaccinia-related kinase 1 (VRK1) and VRK3 are members of the VRK family of serine/threonine kinases and are principally localized in the nucleus. Despite the crucial roles of VRK1/ VRK3 in physiology and disease, the molecular and functional interactions of VRK1/VRK3 are poorly understood. Here, we identified over 200 unreported VRK1/VRK3-interacting candidate proteins by affinity purification and LC-MS/MS. The networks of VRK1 and VRK3 interactomes were found to be associated with important biological processes such as the cell cycle, DNA repair, chromatin assembly, and RNA processing...
August 31, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28927240/temporal-dynamics-of-hippocampal-and-medial-prefrontal-cortex-interactions-during-the-delay-period-of-a-working-memory-guided-foraging-task
#2
Maxym Myroshnychenko, Jeremy K Seamans, Anthony G Phillips, Christopher C Lapish
Connections between the hippocampus (HC) and medial prefrontal cortex (mPFC) are critical for working memory; however, the precise contribution of this pathway is a matter of debate. One suggestion is that it may stabilize retrospective memories of recently encountered task-relevant information. Alternatively, it may be involved in encoding prospective memories, or the internal representation of future goals. To explore these possibilities, simultaneous extracellular recordings were made from mPFC and HC of rats performing the delayed spatial win-shift on a radial maze...
September 12, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28927233/fibroblast-growth-factor-2-mediated-fgfr-erk-signaling-supports-maintenance-of-cancer-stem-like-cells-in-esophageal-squamous-cell-carcinoma
#3
Osamu Maehara, Goki Suda, Mitsuteru Natsuizaka, Shunsuke Ohnishi, Yoshito Komatsu, Fumiyuki Sato, Masato Nakai, Takuya Sho, Kenichi Morikawa, Koji Ogawa, Tomoe Shimazaki, Megumi Kimura, Ayaka Asano, Yoshiyuki Fujimoto, Shinya Ohashi, Shingo Kagawa, Hideaki Kinugasa, Seiji Naganuma, Kelly A Whelan, Hiroshi Nakagawa, Koji Nakagawa, Hiroshi Takeda, Naoya Sakamoto
In esophageal squamous cell carcinoma (ESCC), a subset of cells defined by high expression of CD44 and low expression of CD24 has been reported to possess characteristics of cancer stem-like cells (CSCs). Novel therapies directly targeting CSCs have the potential to improve prognosis of ESCC patients. Although fibroblast growth factor-2 (FGF-2) expression correlates with recurrence and poor survival in ESCC patients, the role of FGF-2 in regulation of ESCC CSCs has yet to be elucidated. We report that FGF-2 is significantly upregulated in CSCs and significantly increases CSC content in ESCC cell lines by inducing epithelial-mesenchymal transition (EMT)...
September 13, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28927191/increasing-mortality-from-ischaemic-heart-disease-in-china-from-2004-to-2010-disproportionate-rise-in-rural-areas-and-elderly-subjects-438-million-person-years-follow-up
#4
Xiaofei Zhang, Arshad A Khan, Ehtesham Ul Haq, Aadil Rahim, Dayi Hu, John Attia, Christopher Oldmeadow, Xiaoyan Ma, Rongjing Ding, Andrew J Boyle
Aims: We sought to ascertain the changes in mortality from ischaemic heart disease (IHD) from 2004 to 2010 in China as the sheer size of China's population makes disease patterns relevant globally. Methods and results: Data on IHD mortality were obtained from the Chinese Centre for Disease Control and Prevention National Disease Surveillance Point System, which includes 161 counties and a population of over 73 million-a representative sample of over 6% of the entire population of China...
January 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28927144/mir-381-inhibits-migration-and-invasion-in-human-gastric-carcinoma-through-downregulatedting-sox4
#5
Mingming Zhang, Shishu Huang, Dan Long
Aberrant expression of microRNAs (miRs) serves essential roles in the generation and progression of various types of human cancer. In the present study, the expression and biological functions of miR-381 in human gastric carcinoma (GC) were focused upon. The results of reverse transcription-quantitative polymerase chain reaction analysis revealed that the expression of miR-381 was significantly downregulated in GC tissue samples. Furthermore, low expression of miR-381 was identified to be associated with lymphatic metastasis and advanced tumor-node-metastasis stage (III+IV)...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927132/downregulation-of-esophageal-cancer-related-gene-4-promotes-proliferation-and-migration-of-hepatocellular-carcinoma
#6
Shujian Ge, Yali Xu, Hongliang Wang, Yaxin Sun, Xiangguo Tian, Zhixin Cao, Xiaoyan Lin, Jiawen Xu, Qiangxiu Wang
Esophageal cancer-related gene 4 (ECRG4) is a candidate tumor suppressor gene, which is involved in cell apoptosis, migration, infection and inflammation responsiveness; however, its expression level and clinical significance in hepatocellular carcinoma (HCC) remains unclear. In the present study, the authors aim to evaluate the clinical significance and potential role of ECRG4 in HCC. Level of ECRG4 protein expression in HCC and peripheral tissues was investigated in tissue specimens obtained from 56 consecutive HCC patients by immunohistochemistry...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927111/luteolin-reduces-migration-of-human-glioblastoma-cell-lines-via-inhibition-of-the-p-igf-1r-pi3k-akt-mtor-signaling-pathway
#7
Qiang Wang, Handong Wang, Yue Jia, Hui Ding, Li Zhang, Hao Pan
Luteolin (3',4',5,7-tetrahydroxyflavone) is a common dietary flavonoid, which has been demonstrated to exert anticancer effects in multiple cancer models. However, the detailed mechanisms underlying the inhibitory effect of luteolin on glioblastoma cell metastasis remain poorly understood. The present study assessed the effects of luteolin in the U251MG and U87MG human glioblastoma cell lines. Luteolin treatment significantly inhibited glioblastoma cell migration, and this effect was associated with downregulated matrix metalloproteinase (MMP)-2, MMP-9 and upregulated tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927099/interleukin-6-identified-as-an-important-factor-in-hypoxia-and-aldehyde-dehydrogenase-based-gefitinib-adaptive-resistance-in-non-small-cell-lung-cancer-cells
#8
Shi-Min An, Hui-Min Lei, Xu-Ping Ding, Fan Sun, Chun Zhang, Ya-Bin Tang, Hong-Zhuan Chen, Ying Shen, Liang Zhu
Gefitinib resistance and relapse of the disease were the greatest challenges facing clinical therapy of non-small-cell lung cancer (NSCLC). Of note, regarding the hypoxia condition in solid tumor tissues in vivo, roles of hypoxia in gefitinib adaptive resistance and its association with lung cancer stem cells (LCSCs) have not been fully elucidated. In the present study, the role of hypoxia in gefitinib adaptive resistance and its association with aldehyde dehydrogenase (ALDH)-based LCSC gefitinib resistance were comparatively studied using RNA-sequencing (RNA-seq) technology...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927057/effect-of-epithelial-growth-factor-on-matrix-metalloproteinase-2-and-e-cadherin-%C3%AE-catenin-expression-in-an-in-situ-model-of-tumorigenesis
#9
Natalia Festugatto Navarini, Vera Cavalcanti De Araújo, Marcelo Sperandio, Marcelo Henrique Napimoga, Lucas Novaes Teixeira, Ney Soares De Araújo, Elizabeth Ferreira Martinez
The aim of the present study was to analyze the in vitro effect of various doses of epidermal growth factor (EGF; 5 and 10 ng/ml) on matrix metalloproteinase-2 (MMP-2) secretion and E-cadherin/β-catenin expression by co-cultured cells that mimic an in situ carcinoma ex-pleomorphic adenoma, where benign myoepithelial cells from a pleomorphic adenoma surround malignant epithelial cells. EGF was supplemented in various doses and the effects were evaluated following four days of cell culture. ELISA was performed to determine MMP-2 secretion levels...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927050/expression-of-tspan-1-gene-in-patients-with-advanced-gastric-cancer
#10
Yaowu Cai, Maosong Zheng, Zhiqiang Zhao, Hanxing Huang, Wenda Fu, Xuefeng Xu
The present study investigated the correlations of the Tspan-1 gene expression with the clinical characteristics and survival prognoses of patients with advanced gastric cancer. A total of 150 patients with advanced gastric cancer were enrolled in the present study, of whom 84 were at stage II and 66 were at stage III according to the tumor node metastasis (TNM) staging; the immunohistochemical staining method and the semi-quantitative PCR method were used to detect the positive expression rates and mRNA relative expression levels of Tspan-1, vascular endothelial growth factor (VEGF), E-cadherin and N-cadherin...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927046/celastrus-orbiculatus-extract-suppresses-the-epithelial-mesenchymal-transition-by-mediating-cytoskeleton-rearrangement-via-inhibition-of-the-cofilin-1-signaling-pathway-in-human-gastric-cancer
#11
Haibo Wang, Hao Gu, Jun Feng, Yayun Qian, Lin Yang, Feng Jin, Xuanyi Wang, Jue Chen, Youyang Shi, Songhua Lu, Min Zhao, Yanqing Liu
Celastrus orbiculatus is a traditional medicinal plant used in the anti-inflammatory and analgesic treatment of various diseases. A previous study demonstrated that ethyl acetate extract of C. orbiculatus (COE) exhibited significant antitumor effects. However, studies concerning the effects and mechanism of COE in terms of suppressing the epithelial-mesenchymal transition (EMT) in human gastric adenocarcinoma cells have not been performed at present. The present study hypothesized that COE may inhibit EMT in gastric adenocarcinoma cells by regulating cell cytoskeleton rearrangement...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927031/prognostic-significance-of-the-epithelial-mesenchymal-transition-factor-zinc-finger-e-box-binding-homeobox-2-in-esophageal-squamous-cell-carcinoma
#12
Xiaodong Huo, Bin Huo, Huixing Wang, Hongdian Zhang, Zhao Ma, Mingjian Yang, Haitao Wang, Zhentao Yu
Zinc finger E-box-binding homeobox 2 (ZEB2) has been reported to mediate epithelial-mesenchymal transition (EMT) and disease progression in several cancer types. However, the expression of ZEB2 in esophageal squamous cell carcinoma (OSCC) and its association with prognosis remains unclear. In the present study, a tissue microarray and immunohistochemistry were used to investigate ZEB2 and epithelial (E-)cadherin expression in OSCC tissues (n=218) and peritumoral esophageal tissues (POT; n=60). There was a significantly increased incidence of positive ZEB2 expression in OSCC tissues compared with the expression in POTs (P<0...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926941/why-ubiquitin-has-not-evolved
#13
Douglas C Allan, James C Phillips
Ubiquitin, discovered less than 50 years ago, tags thousands of diseased proteins for destruction. It is small (only 76 amino acids), and is found unchanged in mammals, birds, fish, and even worms, indicating that ubiquitin is perfect. Key features of its functionality are identified here using critical point thermodynamic scaling theory. These include synchronized pivots and hinges, a stabilizing central pivot, and Fano interference between first- and second-order elements of correlated long-range (allosteric) globular surface shape transitions...
September 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28926938/integrin-activation-contributes-to-lower-cisplatin-sensitivity-in-mv3-melanoma-cells-by-inducing-the-wnt-signalling-pathway
#14
Maria B R Piva, Bastian Jakubzig, Gerd Bendas
BACKGROUND: integrins have been associated with the development of chemotherapy resistant tumour cells, mostly those of hematopoietic origin, by mediating the binding to the extracellular matrix. The relevance for solid tumour cells and the underlying mechanisms remain elusive. METHODS: using MTT assays, we detected the loss in cisplatin sensitivity of human MV3 melanoma cells upon integrin activation. Underlying cellular pathways were evaluated by flow cytometry...
September 16, 2017: Cancers
https://www.readbyqxmd.com/read/28926892/-effect-and-mechanism-of-silibinin-on-the-inhibition-of-alk-positive-nsclc-cells-by-sensitizing-crizotinib
#15
C C Lin, C H Lu, Y H Pan, L Jiao, H Y Chen, L Li, Y He
Objective: To explore the synergistic effect of silibinin combined with crizotinib on anaplastic lymphoma kinase positive (ALK+ ) non-small cell lung cancer (NSCLC) cells and its mechanism. Methods: H2228 and H3122 cells were treated with silibinin, crizotinib alone or in combination. Cell proliferation was measured by 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay and colony formation assay. Migration or invasion ability was tested by wound healing assay or transwell assay, respectively...
September 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28926802/patterns-of-trunk-muscle-activation-during-walking-and-pole-walking-using-statistical-non-parametric-mapping
#16
Luca Zoffoli, Massimiliano Ditroilo, Ario Federici, Francesco Lucertini
This study used surface electromyography (EMG) to investigate the regions and patterns of activity of the external oblique (EO), erector spinae longissimus (ES), multifidus (MU) and rectus abdominis (RA) muscles during walking (W) and pole walking (PW) performed at different speeds and grades. Eighteen healthy adults undertook W and PW on a motorized treadmill at 60% and 100% of their walk-to-run preferred transition speed at 0% and 7% treadmill grade. The Teager-Kaiser energy operator was employed to improve the muscle activity detection and statistical non-parametric mapping based on paired t-tests was used to highlight statistical differences in the EMG patterns corresponding to different trials...
September 9, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28926788/study-of-the-degradation-process-of-ofloxacin-with-free-chlorine-by-using-esi-lcmsms-kinetic-study-by-products-formation-pathways-and-fragmentation-mechanisms
#17
Montaha H Yassine, Ahmad Rifai, Maha Hoteit, Patrick Mazellier, Mohammad Al Iskandarani
This study was conducted to gain a better understanding of the fate of fluoroquinolone antibacterial ofloxacin (OFX) which is the free available chlorine (FAC) in order to determine its effect during water chlorination process. The Direct reactions of FAC with OFX were quite rapid. A half-life of 7.7 s was measured under pseudo-first order conditions in the presence of an excess of total chlorine ([FAC]0 = 13 μM and [OFX]0 = 0.55 μM at pH 7.2 and 20 °C in buffered reagent water. Free chlorine reactions rates were of first-order type in both substrate and oxidant with specific second-order rate constants of 6...
September 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28926705/a-low-temperature-transition-metal-free-cross-dehydrogenative-coupling-protocol-for-the-synthesis-of-3-3-disubstituted-oxindoles
#18
James R Donald, Richard John Kenneth Taylor, Wade F Petersen
A new low-temperature procedure for the synthesis of 3,3-disubstituted 2-oxindoles via cross dehydrogenative coupling (CDC) is reported. The use of a strong, non-reversible base in these reactions has been found to effect a dramatic drop in reaction temperature (to room temperature) relative to the current state-of-the-art (>100 °C). When employing iodine as an 'oxidant', new evidence suggests that this transformation may occur via a transiently stable iodinated intermediate rather than by direct single-electron oxidation...
September 19, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28926702/the-dynamic-feature-of-incipient-polymer-collapse-below-the-theta-point
#19
Yicen Liu, Yibing Dai, Xiaofei Xu
We study the dynamics of polymer chain with gradually changing the solvent quality from good to poor by dissipative particle dynamics simulation. We nd several spectral modes related to internal motions of intrachain interaction. As approaching the coil-to-globule transition point, all fast modes of spectrum ω > 1 (ns)-1 disappear. There is only a slow mode at ω≈0.66 (ns)-1. Moreover, the spectral density at this slow mode reaches a maximum value at the transition point. We suggest that, at the transition point, the chain conformation relaxes to the most probable distribution only by the slow mode...
September 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28926674/prior-mental-disorders-and-lifetime-suicidal-behaviors-among-us-army-soldiers-in-the-army-study-to-assess-risk-and-resilience-in-servicemembers-army-starrs
#20
Alexander J Millner, Robert J Ursano, Irving Hwang, Andrew J King, James A Naifeh, Nancy A Sampson, Alan M Zaslavsky, Murray B Stein, Ronald C Kessler, Matthew K Nock
We report on associations of retrospectively reported temporally prior mental disorders and Army career characteristics with subsequent first onset of suicidal behaviors in a large, representative sample of US Army soldiers who participated in the Consolidated All-Army Survey of the Army Study to Assess Risk and Resilience in Servicemembers (N = 29,982). Results reveal that among men and women, all self-reported lifetime disorders measured (some assessed with screening scales) are associated with subsequent onset of suicide ideation...
September 19, 2017: Suicide & Life-threatening Behavior
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