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https://www.readbyqxmd.com/read/28551893/-the-rationale-of-minimally-invasive-sinus-technique-mist
#1
REVIEW
Meir Warman, Doron Halperin
Chronic rhinosinusitis is one of the most common diseases in the world. Mucosal contact in narrow draining pathways of the sinuses (called transition spaces) may lead to chronic sinusitis by disruption of mucociliary clearance, stasis and blockage of mucous flow. Minimal invasive sinus technique (MIST) is a targeted procedure designed to address the transition spaces surrounding the natural sinus ostia. Surgical clearing disease in a transition space, allows the dependent sinus to recover function. Compared to other conventional endoscopic procedures, MIST can accomplish good and reproducible results in treating patients for chronic rhinosinusitis over long term follow-up...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551861/determinants-of-clinic-absenteeism-a-novel-method-of-examining-distance-from-clinic-and-transportation
#2
Ryan W Dobbs, Neha R Malhotra, Brandon M Caldwell, Raymond Rojas, Daniel M Moreira, Michael R Abern
Delayed treatment and non-adherence are associated with inferior prostate cancer (CaP) outcomes. Missed clinic appointments (MA) are one form of non-adherence that may be preventable. We conducted a retrospective cohort study of 1341 scheduled clinic encounters for men referred to an academic urology clinic for evaluation of known or suspected CaP. Driving distance and public transit times were calculated using a Google Distance Matrix API algorithm. Zip code level data regarding socioeconomic status was obtained from the 2013 American Community Survey...
May 27, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28551845/sostdc1-inhibits-follicular-thyroid-cancer-cell-proliferation-migration-and-emt-via-suppressing-pi3k-akt-and-mapk-erk-signaling-pathways
#3
Qinyi Zhou, Jun Chen, Jialin Feng, Yanan Xu, Wenjie Zheng, Jiadong Wang
The sclerostin domain containing protein 1 (SOSTDC1) is a cell signaling regulator involved in cell physiology and pathology. SOSTDC1 is known to have a suppressive effect on certain kinds of cancer. However, the role of SOSTDC1 in follicular thyroid cancer (FTC) remains unknown. We aimed to investigate if the expression of SOSTDC1 plays any roles in carcinogenesis and metastasis of FTC. We found a significantly down-regulated SOSTDC1 expression in follicular thyroid cancer samples. In addition, our data showed that ectopic expression of SOSTDC1 dramatically inhibited thyroid cancer cell proliferation in vitro and in nude mice...
May 27, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28551789/mitochondria-and-cardiac-hypertrophy
#4
Heberty di Tarso Fernandes Facundo, Robert Eli Brainard, Francisco Rodrigo de Lemos Caldas, Aline Maria Brito Lucas
Cardiac tissue responds to long-term hemodynamic load through initiation of a hypertrophic remodeling program. Importantly, if not counteracted this response will eventually lead to organ failure. Cardiac hypertrophic adaptations are complex, and involve multiple cellular events and the mechanisms underlying the development of cardiac hypertrophy are not well understood. Mitochondrial dysfunction has been indicated as a potential and important player in the development of cardiac hypertrophy. Additionally, substantial evidence shows that a significant portion of mitochondrial processes, necessary for normal cardiomyocyte physiology, are impacted by these hypertrophic changes...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551787/mechanistic-role-of-mptp-in-ischemia-reperfusion-injury
#5
Giampaolo Morciano, Massimo Bonora, Gianluca Campo, Giorgio Aquila, Paola Rizzo, Carlotta Giorgi, Mariusz R Wieckowski, Paolo Pinton
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. The treatment of choice for reducing ischemic injury and limiting infarct size (IS) in patients with ST-segment elevation MI (STEMI) is timely and effective myocardial reperfusion via primary percutaneous coronary intervention (PCI). However, myocardial reperfusion itself may induce further cardiomyocyte death, a phenomenon known as reperfusion injury (RI). The opening of a large pore in the mitochondrial membrane, namely, the mitochondrial permeability transition pore (mPTP), is widely recognized as the final step of RI and is responsible for mitochondrial and cardiomyocyte death...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551785/mitochondria-in-ischemic-heart-disease
#6
L Maximilian Buja
A core feature of ischemic heart disease is injury to cardiomyocytes (CMC). Ischemic CMC manifest the molecular mechanisms to undergo the major forms of cell injury and death, namely, oncotic necrosis, necroptosis, apoptosis and unregulated autophagy. Important modulators of ischemic injury are reperfusion and conditioning. Mitochondria have a major role in mediating the injury to CMC through membrane protein complexes referred to as death channels. Apoptosis is mediated by activation of a channel regulated by the Bcl-2 protein family leading to mitochondrial outer membrane permeabilization (MOMP)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551620/impact-of-small-molecules-on-%C3%AE-catenin-and-e-cadherin-expression-in-hpv16-positive-and-negative-squamous-cell-carcinomas
#7
Benedikt Kramer, Clemens Hock, Johannes David Schultz, Anne Lammert, Beatrice Kuhlin, Richard Birk, Karl Hörmann, Christoph Aderhold
BACKGROUND: The validation of potential molecular targets in head and neck squamous cell carcinoma (SCC) is mandatory. β-Catenin and E-cadherin are crucial for cancer progression through epithelial-mesenchymal transition. We analyzed the effect of the tyrosine kinase inhibitors nilotinib, dasatinib, erlotinib and gefitinib on β-catenin and E-cadherin expression in SCC with respect to human papillomavirus (HPV) status. MATERIALS AND METHODS: Expression of β-catenin and E-cadherin in cell lines UMSCC 11A, UMSCC 14C and CERV196 under the influence of tyrosine kinase inhibitors were analyzed by enzyme-linked immunosorbent assay...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551567/-no-place-like-home-aging-in-post-reform-beijing
#8
Jie Yu, Mark W Rosenberg
This study shows the Western theorization and interpretation of aging, place and health are not well suited to a non-western case. The current generation of older Chinese has experienced the transition from a planned economy to a socialist market economy. Urban changes have taken place in various ways. This study explains the spatio-temporal processes of older people with their changing places by conducting in-depth interviews with 47 older people living at home in Beijing. Their generational consciousness and old place identities are deeply rooted in pre-reform Collectivism and shaped by socialist ideologies of the past...
May 25, 2017: Health & Place
https://www.readbyqxmd.com/read/28551510/food-transit-duration-is-associated-with-the-number-of-stage-ii-transport-cycles-when-eating-solid-food
#9
Takashi Hiraoka, Jeffrey B Palmer, Martin B Brodsky, Mitsumasa Yoda, Haruhi Inokuchi, Akio Tsubahara
OBJECTIVE: When eating solids, stage II transport (St2Tr) propels triturated food into the pharynx for bolus formation and storage before swallowing. Although the existence of St2Tr is acknowledged, the reason for its existence remains unclear. Understanding it may facilitate development of food appropriate for individuals with dysphagia. The purpose of this study was to explore how measures of duration of eating and swallowing affect the number of St2Tr cycles. DESIGN: Videofluorography was performed on 13 healthy subjects eating 6-g squares of banana, tofu, and cookies...
May 20, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28551335/transition-path-times-measured-by-single-molecule-spectroscopy
#10
REVIEW
Hoi Sung Chung
The transition path is a tiny fraction of a molecular trajectory during which the free-energy barrier is crossed. It is a single-molecule property and contains all mechanistic information of folding processes of biomolecules such as proteins and nucleic acids. However, the transition path has been difficult to probe because it is short and rarely visited when transitions actually occur. Recent technical advances in single-molecule spectroscopy have made it possible to directly probe transition paths, which has opened up new theoretical and experimental approaches to investigating folding mechanisms...
May 24, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28551276/responsible-surgical-innovation-and-research-in-maternal-fetal-surgery
#11
REVIEW
Ryan M Antiel, Alan W Flake
The field of maternal-fetal intervention is rapidly evolving with new technologies and innovations. This raises complex ethical and medico-legal challenges related to what constitutes innovative treatment versus human experimentation, with or without the umbrella of "medical research." There exists a gray zone between these black and white classifications, but there are also clear guidelines that should be responsibly negotiated when making the essential transition between an innovative treatment and a validated therapy...
May 24, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28551243/development-and-validation-of-a-robust-high-performance-liquid-chromatographic-method-for-the-analysis-of-monacolins-in-red-yeast-rice
#12
Mart Theunis, Tania Naessens, Veronique Verhoeven, Nina Hermans, Sandra Apers
A robust analytical method, using reversed phase high-performance liquid chromatography with diode array detection, was developed and validated for the quantification of monacolins in red yeast rice bulk products. Tests on the composition of the extraction solvent, extraction time and the number of repetitions of extraction were evaluated with the aim of complete extraction of the monacolins and minimal transitions between the monacolins during analysis. Monacolin K (acid form), monacolin K (lactone form) and minor monacolin peaks were separated on a C18 column (250×4...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28551242/effect-of-mitochondrial-apoptotic-activation-through-the-mitochondrial-membrane-permeability-transition-pore-on-yak-meat-tenderness-during-postmortem-aging
#13
Lin-Lin Wang, Ling Han, Xiu-Li Ma, Qun-Li Yu, Suo-Nan Zhao
The effect of membrane permeability transition pore dependent mitochondrial apoptotic activation on yak meat tenderness was investigated. Results indicate that MPTP opening increased significantly and the mitochondrial membrane potential decreased markedly in the early aging process (P<0.05). Cytochrome c was released from the mitochondria to the cytoplasm via the MPTP in the early period. Meanwhile, the activation of procaspase-9 occurred earlier than that of procaspase-3. Cyclosporin A suppressed the MPTP opening, depolarization of the mitochondrial membrane potential, activities of caspase-9 and caspase-3, apoptosis rate, myofibril fragmentation index, reactive oxygen species generation, and Ca(2+) levels...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28551192/differences-in-liver-functionality-indexes-in-peripartal-dairy-cows-fed-rumen-protected-methionine-or-choline-are-associated-with-performance-oxidative-stress-status-and-plasma-amino-acid-profiles
#14
Z Zhou, E Trevisi, D N Luchini, J J Loor
The liver functionality index (LFI) represents an assessment of transition cow metabolic health by measuring changes in biomarkers associated with liver plasma protein synthesis (albumin), lipoprotein synthesis (cholesterol), and heme catabolism (bilirubin). The present analysis was conducted to determine the role of peripartal rumen-protected Met or choline (CHOL) supplementation on LFI groupings, and to assess relationships with performance, inflammation, oxidative stress status, and plasma AA profiles. A cohort of 40 multiparous Holstein cows that were part of a randomized complete block design with 2 × 2 factorial arrangement of Met (Smartamine M, Adisseo NA, Alpharetta, GA) and CHOL (ReaShure, Balchem Inc...
May 24, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28551184/the-effect-of-different-treatments-for-early-lactation-hyperketonemia-on-blood-%C3%AE-hydroxybutyrate-plasma-nonesterified-fatty-acids-glucose-insulin-and-glucagon-in-dairy-cattle
#15
S Mann, F A Leal Yepes, E Behling-Kelly, J A A McArt
Despite increased efforts in preventing the occurrence of metabolic disorders in transition cows, hyperketonemia remains a frequent early-lactation metabolic disease affecting an average of 40% of cows in herds in the United States. Despite the demonstrated economic effect of this disorder, controlled clinical trials comparing different treatment strategies in affected cows are lacking. The objective of our study was to investigate the effect of treatment with intravenous glucose, oral propylene glycol, or a combination of both on the reduction in blood β-hydroxybutyrate (BHB) concentrations of early-lactation hyperketonemic dairy cows...
May 24, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28551173/natural-orifice-transluminal-endoscopic-partial-prostatectomy-a-real-time-image-guided-focal-extirpative-feasibility-study
#16
Haidar M Abdul-Muhsin, Nicholas J Jakob, Akira Kawashima, Alvin C Silva, Melisa L Stanton, Gianni Moshero, Erik P Castle, Paul E Andrews, Mitchell R Humphreys
OBJECTIVE: To assess the feasibility of focal endoscopic excision of PCa under guidance of real time magnetic resonance imaging/ultrasound fusion (MUF). METHODS: Using a cadaveric model, multi-focal PCa was simulated using two MRI-compatible fiducial markers.These were inserted transrectally and used to generate regions of interests (ROIs) on a 1.5 T surface coil MRI. The first marker was placed in the right mid peripheral zone (ROI 1) and the second marker was placed in the left seminal vesicle as a referent lesion for subsequent imaging...
May 24, 2017: Urology
https://www.readbyqxmd.com/read/28551083/the-effects-of-yoga-and-self-esteem-on-menopausal-symptoms-and-quality-of-life-in-breast-cancer-survivors-a-secondary-analysis-of-a-randomized-controlled-trial
#17
Anna K Koch, Sybille Rabsilber, Romy Lauche, Sherko Kümmel, Gustav Dobos, Jost Langhorst, Holger Cramer
OBJECTIVES: Previous research has found that yoga can enhance quality of life and ease menopausal symptoms of breast cancer survivors. The study examined whether self-esteem mediated the effects of yoga on quality of life, fatigue and menopausal symptoms, utilizing validated outcome measures. STUDY DESIGN: This is a secondary analysis of a randomized controlled trial comparing the effects of yoga with those of usual care in 40 breast cancer survivors who suffered from menopausal symptoms...
May 13, 2017: Maturitas
https://www.readbyqxmd.com/read/28551066/socially-induced-plasticity-in-sensorimotor-gating-in-the-african-cichlid-fish-astatotilapia-burtoni
#18
Heike Neumeister, Mila Adelman, William Gallagher, Jiangtao Gou, Karin Merrins, Melissa Perkowski, Stephanie Shih, Beth Terranova, Thomas Preuss
Deficits in sensorimotor gating (PPI), social defeat and social withdrawal are hallmark features of several neurological and neuropsychiatric disorders. However, the link between social environment and PPI i.e., the possible role of social defeat in driving PPI plasticity, is far from clear. Here we explored these questions in the African cichlid fish Astatotilapia burtoni, where males exist as two distinct yet reversible phenotypes. In fish communities, DOMs exhibit frequent aggressive and territorial behaviors, threatening and attacking SUBs, which respond either by engaging in fights and fleeing, or by avoiding interaction with DOMs altogether...
May 24, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28551043/improving-transitions-to-post-acute-care-for-elderly-patients-using-a-novel-video-conferencing-program-echo-care-transitions
#19
Amber B Moore, J Elyse Krupp, Alyssa B Dufour, Mousumi Sircar, Thomas G Travison, Alan Abrams, Grace Farris, Melissa L P Mattison, Lewis A Lipsitz
PURPOSE: Within 30 days of hospital discharge to a skilled nursing facility, older adults are at high risk for death, re-hospitalization and high-cost healthcare. The purpose of this study was to examine whether a novel videoconference program called Extension for Community Health Outcomes-Care Transitions (ECHO-CT) that connects an interdisciplinary hospital-based team with clinicians at skilled nursing facilities, reduces patient mortality, hospital readmission, skilled nursing facility length of stay and 30-day health care costs...
May 24, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28551000/physician-satisfaction-with-transition-from-cpoe-to-paper-based-prescription
#20
N Griffon, M Schuers, M Joulakian, M Bubenheim, J-P Leroy, S J Darmoni
INTRODUCTION: In January 2015, Rouen University Hospital's information system experienced serious issues. It was necessary to rapidly switch from the computerized provider order entry (CPOE) system towards a paper-based order entry (PBOE) system. This was an opportunity to evaluate prescriber opinion on the two provider order entry (POE) systems. METHODS: All residents were asked to fill an augmented version of the POE satisfaction and usage survey for both POE systems...
July 2017: International Journal of Medical Informatics
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