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Keywords Diversion colitis histopatholo...

Diversion colitis histopathologic features

https://read.qxmd.com/read/38104876/bioactives-and-metabolites-of-tetrastigma-hemsleyanum-root-extract-alleviate-dss-induced-ulcerative-colitis-by-targeting-the-syk-protein-in-the-b-cell-receptor-signaling-pathway
#1
JOURNAL ARTICLE
Zhengquan Feng, Wei Ye, Lifang Feng
ETHNOPHARMACOLOGICAL RELEVANCE: Tetrastigma hemsleyanum is an endemic Chinese herb with a wide range of pharmacological activities, including anti-inflammatory, antiviral, antioxidant, antitumor, and immunomodulatory activities. However, the effect and mechanisms of the anti-inflammatory activity of T. hemsleyanum root extract against dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) have not yet been fully investigated. AIM OF THE STUDY: This study aimed to explore the therapeutic effect and molecular mechanisms of T...
December 15, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37711388/protective-effect-of-carbon-dots-derived-from-scrambled-coptidis-rhizoma-against-ulcerative-colitis-in-mice
#2
JOURNAL ARTICLE
Yanfang Mou, Xue Bai, Huagen Ma, Tingjie Li, Yafang Zhao, Tong Wu, Yue Zhang, Huihua Qu, Hui Kong, Xueqian Wang, Yan Zhao
Introduction: Ulcerative colitis (UC) is a chronic and progressive inflammatory disease of the intestines. The primary symptoms, such as bloody diarrhea, can result in weight loss and significantly diminish the patient's quality of life. Despite considerable research endeavors, this disease remains incurable. The scrambled Coptidis Rhizoma (SCR) has a rich historical background in traditional Chinese medicine as a remedy for UC. Drawing from a wealth of substantial clinical practices, this study is focused on investigating the protective effects and underlying mechanisms of the active component of SCR, namely SCR-based carbon dots (SCR-CDs), in the treatment of UC...
2023: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/37533828/probiotics-treatment-ameliorated-mycophenolic-acid-induced-colitis-by-enhancing-intestinal-barrier-function-and-improving-intestinal-microbiota-dysbiosis-in-mice
#3
JOURNAL ARTICLE
Pengpeng Zhang, Jinwen Chen, Yingzi Ming, Ying Niu
BACKGROUND: Mycophenolic acid (MPA)-induced colitis was still a severe side effect and challenge faced by solid transplant recipients. We aimed to explore the function and mechanism of probiotics in the treatment of MPA-induced colitis. METHODS: In this study, 15 mice (C57BL/6) were randomly assigned into three groups: control (CNTL) group ( n = 5), MPA group ( n = 5) and the MPA + Probiotic group ( n = 5). Bifid Triple Viable capsules, which were drugs for clinical use and consisted of Bifidobacterium longum , Lactobacillus acidophilus , and Enterococcus faecalis , were used in Probiotic group...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/35383871/histological-diversity-of-anti-pd1-induced-colitis
#4
JOURNAL ARTICLE
Stratigoula Sakellariou, Evgenia Papathanasiou, Marina Perdiki, Maria Sotiropoulou, Evangelia Zampeli, Spyros Michopoulos, Giorgos Bamias, Ioanna Delladetsima
AIM: Histological data on anti-PD1-associated colitis are limited, while the colitis subtypes are still not clearly defined and different terms are being used. The aim of the study was to explore the histopathology of anti-PD1-induced colitis. METHODS AND RESULTS: Colonic biopsies from 9 patients under anti-PD1 agents presenting diarrhea were examined. Histological evaluation revealed colitis of mild to moderate severity in almost all cases. Four distinct dominant histological patterns were identified with nearly the same incidence: Ulcerative colitis (UC)-like (n=2), GVHD-like (n=2), collagenous-like (n=3) and a mixed colitis pattern combining features of microscopic and UC-like colitis (n=2)...
April 6, 2022: Histology and Histopathology
https://read.qxmd.com/read/34515105/gastrointestinal-adverse-events-induced-by-immune-checkpoint-inhibitors
#5
REVIEW
Shunichi Yanai, Yosuke Toya, Tamotsu Sugai, Takayuki Matsumoto
BACKGROUND: As immune-checkpoint inhibitors (ICI) are becoming standard therapies for malignant tumors, increasing attention has been paid to their associated immune-related adverse events (irAEs). The gastrointestinal tract is the major site of irAEs, and it has recently become evident that the large bowel is the most frequently affected region. The aim of this narrative review was to clarify the endoscopic and histopathologic findings of and treatments for ICI-induced colitis. SUMMARY: Endoscopic findings of ICI-induced colitis include a reddish, edematous mucosa with increased mucous exudate, loss of normal vascularity, and a granular mucosa with or without mucosal breaks...
2021: Digestion
https://read.qxmd.com/read/33686310/histopathology-of-non-ibd-colitis-a-practical-approach-from-the-italian-group-for-the-study-of-the-gastrointestinal-tract-gipad
#6
REVIEW
Vincenzo Villanacci, Luca Reggiani-Bonetti, Giuseppe Leoncini, Paola Parente, Moris Cadei, Luca Albarello, Giulio Mandelli, Alessandro Caputo
Non-IBD colitides (NIBDC) are intestinal diseases clinically and endoscopically overlapping with Inflammatory Bowel Diseases (IBD), sometimes with a similar histological picture. NIBDC include entities such as infectious colitis, ischemic colitis, pseudomembranous colitis, eosinophilic colitis, autoimmune enterocolitis, segmental colitis associated with diverticulosis, drug-induced colitis, radiation-induced colitis, diversion colitis, and microscopic colitis, this last including two entities: collagenous and lymphocytic colitis...
February 2021: Pathologica
https://read.qxmd.com/read/28884123/deviation-of-the-fecal-stream-in-colonic-bowel-segments-results-in-increased-numbers-of-isolated-lymphoid-follicles-in-the-submucosal-compartment-in-a-novel-murine-model-of-diversion-colitis
#7
JOURNAL ARTICLE
Annabel Kleinwort, Paula Döring, Christine Hackbarth, Claus-Dieter Heidecke, Tobias Schulze
INTRODUCTION: Diversion colitis is a significant health problem due to its high incidence in patients with diverting enterostomy. This mucosal inflammation presents characteristic histopathological features allowing for the differentiation of this entity from other inflammatory bowel diseases. The pathophysiology of this disease remains ill-defined, in part due to the lack of appropriate animal models. The present study was performed in order to develop and characterize a murine model of diversion colitis...
2017: BioMed Research International
https://read.qxmd.com/read/26479413/morphological-spectrum-of-neovaginitis-in-autologous-sigmoid-transplant-patients
#8
JOURNAL ARTICLE
Wouter B van der Sluis, Eskelina A Neefjes-Borst, Mark-Bram Bouman, Wilhelmus J H J Meijerink, Nanne K H De Boer, Margriet G Mullender, Adriaan A van Bodegraven
AIMS: Autologous intestinal grafts are used to (re)create a vagina in selected patients. The risk of diversion colitis is mentioned as a disadvantage, although its prevalence remains unclear. This study aimed to assess the histopathological characteristics of the sigmoid-derived neovaginal epithelial lining after diverting surgery and correlate these with clinical findings. METHODS AND RESULTS: Biopsy specimens were obtained from the epithelial lining of the sigmoid-derived neovagina and remaining rectosigmoid as regular follow-up from 26 patients with a median age of 22 years (range 19-52) and median postoperative follow-up of 13 months (range 6-52)...
June 2016: Histopathology
https://read.qxmd.com/read/25574078/differential-diagnosis-in-inflammatory-bowel-disease-colitis-state-of-the-art-and-future-perspectives
#9
REVIEW
Gian Eugenio Tontini, Maurizio Vecchi, Luca Pastorelli, Markus F Neurath, Helmut Neumann
Distinction between Crohn's disease of the colon-rectum and ulcerative colitis or inflammatory bowel disease (IBD) type unclassified can be of pivotal importance for a tailored clinical management, as each entity often involves specific therapeutic strategies and prognosis. Nonetheless, no gold standard is available and the uncertainty of diagnosis may frequently lead to misclassification or repeated examinations. Hence, we have performed a literature search to address the problem of differential diagnosis in IBD colitis, revised current and emerging diagnostic tools and refined disease classification strategies...
January 7, 2015: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/23999270/inflammatory-bowel-disease-biopsies-updated-british-society-of-gastroenterology-reporting-guidelines
#10
JOURNAL ARTICLE
Roger M Feakins
Accurate histopathological assessment of biopsies is important for the diagnosis, subclassification, and management of chronic idiopathic inflammatory bowel disease (IBD). British Society of Gastroenterology (BSG) guidelines for the initial histopathological diagnosis of IBD were published in 1997. Changes since then include: more widespread use of full colonoscopy; greater recognition of the effects of time and treatment; improved documentation of variations in anatomical distribution; better understanding of the mimics of IBD; significant progress in clinical management; and modifications of terminology...
December 2013: Journal of Clinical Pathology
https://read.qxmd.com/read/22849731/the-differential-diagnosis-of-colitis-in-endoscopic-biopsy-specimens-a-review-article
#11
REVIEW
Lisa A Cerilli, Joel K Greenson
CONTEXT: A variety of inflammatory disorders may affect the colon, with widely differing clinical outcomes and management. These conditions encompass a spectrum of acute and chronic conditions. OBJECTIVE: Review the pathology of the major colitides and highlight the most diagnostically useful features. DATA SOURCES: Review of recent literature supplemented with personal experience in the field of gastrointestinal pathology. CONCLUSIONS: The etiologies associated with the various types of colitis are diverse and the range of histologic changes is somewhat limited...
August 2012: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/21233087/numerous-igg4-positive-plasma-cells-are-ubiquitous-in-diverse-localised-non-specific-chronic-inflammatory-conditions-and-need-to-be-distinguished-from-igg4-related-systemic-disorders
#12
JOURNAL ARTICLE
Johanna D Strehl, Arndt Hartmann, Abbas Agaimy
BACKGROUND: IgG4-related systemic fibrosclerosis is a recently defined disorder characterised by a diffuse or tumefactive inflammatory reaction rich in IgG4-positive plasma cells associated with sclerosis and obliterative phlebitis. Although characteristic histopathological features are essential for the diagnosis of these disorders, to date there exists no consensus regarding the cut-off values used to define a 'significant IgG4-positive plasma cell count,' and data regarding the distribution of IgG4-positive plasma cells under common (non-specific) inflammatory conditions are lacking...
March 2011: Journal of Clinical Pathology
https://read.qxmd.com/read/19573460/-clinical-and-colonoscopic-characteristics-of-pediatric-inflammatory-bowel-disease
#13
JOURNAL ARTICLE
You-you Luo, Jie Chen
OBJECTIVE: To analyze clinical manifestations, endoscopic and histological features for establishing a diagnosis of pediatric inflammatory bowel disease (IBD). METHOD: Thirty-four inpatients with inflammatory bowel disease (ulcerative colitis/UC/: 24; Crohn's disease/CD/:10) were enrolled into this study. Data of clinical manifestations, laboratory values, endoscopic findings and histopathological features of biopsy material were analyzed. RESULT: Four children had mild/moderate active Crohn's disease...
February 2009: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/16012959/collagenous-mucosal-inflammatory-diseases-of-the-gastrointestinal-tract
#14
REVIEW
Hugh J Freeman
Collagenous mucosal inflammatory diseases involve the columnar-lined gastric and intestinal mucosa and have become recognized increasingly as a significant cause of symptomatic morbidity, particularly in middle-aged and elderly women, especially with watery diarrhea. Still, mechanisms involved in the pathogenesis of this diarrhea remain poorly understood and require further elucidation. The prognosis and long-term outcome of these disorders has been documented only to a limited extent. Recent clinical and pathologic studies have indicated that collagenous mucosal inflammatory disease is a more extensive pathologic process that concomitantly may involve several sites in the gastric and intestinal mucosa...
July 2005: Gastroenterology
https://read.qxmd.com/read/15527672/the-pathobiology-of-eosinophilic-gastroenteritis-of-childhood-is-it-really-the-eosinophil-allergic-mediated-or-something-else
#15
REVIEW
Peter Ngo, Glenn Furuta, Wesley Burks
Over the past decade clinicians have witnessed a dramatic rise in the prevalence of eosinophilic gastrointestinal diseases. Diverse symptoms, a broad range of endoscopic findings, and varying histopathologic features pose several questions: Do eosinophils represent an allergic response? What mechanisms drive eosinophils to specific mucosal targets? How do eosinophils affect the gastrointestinal tissues? Recent clinical and basic studies are investigating the pathogenesis of eosinophilic gastrointestinal diseases...
December 2004: Current Gastroenterology Reports
https://read.qxmd.com/read/11584399/diversion-procto-colitis-response-to-treatment-with-short-chain-fatty-acids
#16
JOURNAL ARTICLE
E M Kiely, N A Ajayi, R A Wheeler, M Malone
BACKGROUND/PURPOSE: Diversion procto-colitis (DPC) results from a deficiency of luminal short-chain fatty acids (SCFAs). Endoscopic and histopathologic features of the disorder are almost universally present in defunctioned bowel, but symptomatic DPC is less common. METHODS: Five children with symptomatic DPC underwent endoscopy and rectosigmoid biopsies. An endoscopic index (EI) was used to quantify disease severity. An SCFA mixture was administered into the defunctioned bowel...
October 2001: Journal of Pediatric Surgery
https://read.qxmd.com/read/10953364/-indeterminate-colitis-nonspecific-inflammatory-bowel-disease
#17
REVIEW
M Micev
Distinguishing of indeterminate colitis from ulcerative colitis or Crohn's disease in more than 10% of IBD cases as separate diagnostic category (IIBD) is defined by: first, overlapping or paucity of features of two major IBD forms in acute fulminant colitides and few chronic slowly progressive cases without differentiating markers of chronicity, and second, inability to reach specific diagnosis during or after completed clinical, radiological, endoscopical and histopathological examination of chronic colitis with inconclusive presentation of IBD-compatible cases...
2000: Acta Chirurgica Iugoslavica
https://read.qxmd.com/read/10372278/the-atypical-colitides
#18
REVIEW
F M Giardiello, A J Lazenby
Collangenous colitis is a clinicopathologic syndrome characterized by (1) chronic watery diarrhea and crampy abdominal pain and (2) distinctive colorectal histopathology that includes a subepithelial collagen band, prominent chronic inflammation in the lamina propria, and increased intraepithelial lymphocytes. Lymphocytic colitis has similar clinical features to collangenous colitis, the main symptom being chronic watery diarrhea. Diversion colitis is an inflammatory process that arises in segments of the large intestine that are excluded from the fecal stream...
June 1999: Gastroenterology Clinics of North America
https://read.qxmd.com/read/9934577/diversion-colitis-new-light-through-old-windows
#19
REVIEW
C M Edwards, B George, B Warren
Diversion proctocolitis is an iatrogenic disorder caused by surgical diversion of the faecal stream away from the colorectal mucosa. Such surgery may be necessary in cases of tumour, trauma or inflammatory conditions of the colorectum. Histopathological change is characterized by a chronic lymphoplasmacytic inflammatory infiltrate, and the hallmark feature, lymphoid follicular hyperplasia. Histological appearances are determined by the disease state of the colonic mucosa prior to faecal diversion. Macroscopic appearances may vary considerably, but often include aphthoid ulceration...
January 1999: Histopathology
https://read.qxmd.com/read/8432517/the-morphologic-features-of-diversion-colitis-studies-of-a-pediatric-population-with-no-other-disease-of-the-intestinal-mucosa
#20
JOURNAL ARTICLE
S Haque, R N Eisen, A B West
Studies of diversion colitis have not shown a consistent pattern of histopathologic features, and many descriptions are difficult to interpret because of the presence of underlying intestinal mucosal disease. To define the histologic changes in patients free of other mucosal inflammatory disease, we studied the resected segments of bypassed colorectum from 37 patients with Hirschsprung's disease treated by a two-stage procedure, using rectal biopsy specimens taken for initial diagnosis and trimmings from proximal to the stoma as controls...
February 1993: Human Pathology
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