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Littman, D

David E Goodrich, Elizabeth A Klingaman, Lilia Verchinina, Richard W Goldberg, Alyson J Littman, Carol A Janney, Hyungjin Myra Kim, Shira Maguen, Katherine D Hoerster, Richard R Owen, Robert G Holleman, Pia Roman, Zongshan Lai, Nicholas W Bowersox
PURPOSE: Obesity disproportionately burdens individuals with serious mental illness (SMI), especially women. This observational study investigated whether there were sex differences in weight loss and program participation among veterans with SMI enrolled in the Veterans Health Administration's (VHA) MOVE! weight management program. PROCEDURES: Participants were identified from a national cohort of 148,254 veterans enrolled in MOVE! during fiscal years 2008 through 2012 who attended two or more sessions within 12 months of enrollment...
July 2016: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
Erin D Bouldin, Alyson J Littman, Edwin Wong, Chuan-Fen Liu, Leslie Taylor, Kenneth Rice, Gayle E Reiber
Veterans who use Veterans Health Affairs (VHA) have the option of enrolling in and obtaining care from other non-VA sources. Dual system use may improve care by increasing options or it may result in poorer outcomes because of fragmented care. Our objective was to assess whether dual system use of VHA and Medicare for wound care was associated with chronic wound healing. We conducted a retrospective cohort study of 227 Medicare-enrolled VHA users in the Pacific Northwest who had an incident, chronic lower limb wound between October 1, 2006 and September 30, 2007 identified through VHA chart review...
June 13, 2016: Wound Repair and Regeneration
Shira Maguen, Katherine D Hoerster, Alyson J Littman, Elizabeth A Klingaman, Gina Evans-Hudnall, Rob Holleman, H Myra Kim, David E Goodrich
BACKGROUND: Three-quarters of Iraq and Afghanistan veterans enrolled in Veterans Health Administration (VHA) care are overweight or obese. The VHA MOVE!® weight management program can mitigate the risks of obesity-related morbidity. However, many Iraq and Afghanistan veterans experience barriers to VHA services, which may affect participation, especially among those with posttraumatic stress disorder (PTSD) and/or depression. Little is known about MOVE! engagement among recent veterans...
March 15, 2016: Journal of Affective Disorders
Erin D Bouldin, Mary Lou Thompson, Edward J Boyko, David C Morgenroth, Alyson J Littman
OBJECTIVE: To characterize weight change after amputation by identifying typical weight trajectories in men with incident lower-limb amputation (LLA) and describing characteristics associated with each trajectory. DESIGN: Retrospective cohort study and analyzed using group-based trajectory modeling. SETTING: Administrative data. PARTICIPANTS: Veterans who were men (N=759), living in the Northwest United States, and who had an incident toe, foot, or leg amputation between 1997 and 2008 and at least 18 months of amputation-free survival thereafter...
January 2016: Archives of Physical Medicine and Rehabilitation
MacLean Sellars, Jun R Huh, Kenneth Day, Priya D Issuree, Carolina Galan, Stephane Gobeil, Devin Absher, Michael R Green, Dan R Littman
During development, progenitor cells with binary potential give rise to daughter cells that have distinct functions. Heritable epigenetic mechanisms then lock in gene-expression programs that define lineage identity. Regulation of the gene encoding the T cell-specific coreceptor CD4 in helper and cytotoxic T cells exemplifies this process, with enhancer- and silencer-regulated establishment of epigenetic memory for stable gene expression and repression, respectively. Using a genetic screen, we identified the DNA-methylation machinery as essential for maintaining silencing of Cd4 in the cytotoxic lineage...
July 2015: Nature Immunology
Erin D Bouldin, Leslie L Taylor, Alyson J Littman, Mahsa Karavan, Kenneth Rice, Gayle E Reiber
PURPOSE: Veterans in rural areas generally have lower health care utilization than veterans in urban areas, but the impact of this difference on health outcomes has received little study. Chronic wounds provide a model for studying access to complex chronic care since they often are related to underlying health conditions and require lengthy treatment. Our goals were to describe chronic wound care utilization among rural and urban veterans and to determine the association between rural residence and wound healing...
2015: Journal of Rural Health
Zachary D Kurtz, Christian L Müller, Emily R Miraldi, Dan R Littman, Martin J Blaser, Richard A Bonneau
16S ribosomal RNA (rRNA) gene and other environmental sequencing techniques provide snapshots of microbial communities, revealing phylogeny and the abundances of microbial populations across diverse ecosystems. While changes in microbial community structure are demonstrably associated with certain environmental conditions (from metabolic and immunological health in mammals to ecological stability in soils and oceans), identification of underlying mechanisms requires new statistical tools, as these datasets present several technical challenges...
May 2015: PLoS Computational Biology
Edward J Boyko, Daniel W Trone, Arthur V Peterson, Isabel G Jacobson, Alyson J Littman, Charles Maynard, Amber D Seelig, Nancy F Crum-Cianflone, Jonathan B Bricker
OBJECTIVES: We examined whether military service, including deployment and combat experience, were related to smoking initiation and relapse. METHODS: We included older (panel 1) and younger (panel 2) participants in the Millennium Cohort Study. Never smokers were followed for 3 to 6 years for smoking initiation, and former smokers were followed for relapse. Complementary log-log regression models estimated the relative risk (RR) of initiation and relapse by military exposure while adjusting for demographic, health, and lifestyle factors...
June 2015: American Journal of Public Health
A J Littman, L V McFarland, M L Thompson, E D Bouldin, D E Arterburn, B R Majerczyk, E J Boyko
BACKGROUND: Obesity is thought to be highly prevalent in persons with lower extremity amputations (LEAs) and can impair physical and social functioning. OBJECTIVE: The aim of this study was to determine the prevalence of weight loss intention, weight loss strategies, dietary patterns, and barriers to making dietary changes, and their associations with body mass index (BMI, kg/m(2)), amputation characteristics, health status, and socioeconomic factors. METHODS: We conducted a cross-sectional study (n = 150) using data from a self-administered questionnaire...
July 2015: Disability and Health Journal
Emily C Williams, Melissa A Frasco, Isabel G Jacobson, Charles Maynard, Alyson J Littman, Amber D Seelig, Nancy F Crum-Cianflone, Anna Nagel, Edward J Boyko
BACKGROUND: Military service members may be prone to relapse to problem drinking after remission, given a culture of alcohol use as a coping mechanism for stressful or traumatic events associated with military duties or exposures. However, the prevalence and correlates of relapse are unknown. We sought to identify socio-demographic, military, behavioral, and health characteristics associated with relapse among current and former military members with remittent problem drinking. METHODS: Participants in the longitudinal Millennium Cohort Study who reported problem drinking at baseline (2001-2003) and were remittent at first follow-up (2004-2006) were included (n=6909)...
March 1, 2015: Drug and Alcohol Dependence
Alyson J Littman, Laura J Damschroder, Lilia Verchinina, Zongshan Lai, Hyungjin Myra Kim, Katherine D Hoerster, Elizabeth A Klingaman, Richard W Goldberg, Richard R Owen, David E Goodrich
OBJECTIVE: The objective was to determine whether obesity screening and weight management program participation and outcomes are equitable for individuals with serious mental illness (SMI) and depressive disorder (DD) compared to those without SMI/DD in Veterans Health Administration (VHA), the largest integrated US health system, which requires obesity screening and offers weight management to all in need. METHODS: We used chart-reviewed, clinical and administrative VHA data from fiscal years 2010-2012 to estimate obesity screening and participation in the VHA's weight management program (MOVE!) across groups...
January 2015: General Hospital Psychiatry
Cindy Ke Zhou, Alyson J Littman, Paul H Levine, Heather J Hoffman, Sean D Cleary, Emily White, Michael B Cook
BACKGROUND: Male pattern baldness and prostate cancer may share common pathophysiological mechanisms in terms of advancing age, heritability, and endogenous hormones. Results from previous epidemiologic studies are inconsistent. Therefore, we investigated the association of prostate cancer risks with male pattern baldness at age 30 years, age 45 years, and baseline (median age = 60.5 years) in the VITamins And Lifestyle (VITAL) cohort study. METHODS: We included 32,583 men who were aged 50-76 years and without prior cancer diagnosis (excluding non-melanoma skin cancer) at the start of follow-up...
March 1, 2015: Prostate
Adam B Schwartz, Gina Siddiqui, John S Barbieri, Amana L Akhtar, Woojin Kim, Ryan Littman-Quinn, Emily F Conant, Narainder K Gupta, Bryan A Pukenas, Parvati Ramchandani, Anna S Lev-Toaff, Jennifer D Tobey, Drew A Torigian, Amy H Praestgaard, Carrie L Kovarik
We assessed the diagnostic accuracy of digital photographs of plain film chest X-rays (CXRs) obtained using a mobile phone. The study was a randomized, non-inferiority trial, in which physical plain film CXRs viewed on a light box were compared with digital photographs of plain film CXRs. CXRs were selected from a database of radiology studies to show common pathologies found in Botswana associated with pneumonia, lung carcinoma, tuberculosis, pneumothorax and interstitial disease, as well as normal findings...
December 2014: Journal of Telemedicine and Telecare
A D Short, B Catchpole, A M Boag, L J Kennedy, J Massey, S Rothwell, P S Henthorn, M P Littman, E Husebye, B Ollier
No abstract text is available yet for this article.
November 1, 2014: Veterinary Record
Katherine D Hoerster, Zongshan Lai, David E Goodrich, Laura J Damschroder, Alyson J Littman, Elizabeth A Klingaman, Karin M Nelson, Amy M Kilbourne
OBJECTIVE: This evaluation compared the effectiveness of MOVE!, a U.S. Veterans Health Administration (VHA) weight management program, among veterans with posttraumatic stress disorder (PTSD), other mental conditions, or no mental health diagnoses. METHODS: VHA administrative data from 2008 to 2012 were used to estimate adjusted six- and 12-month weight change and ≥5% weight loss among 20,819 veterans with "intense and sustained" MOVE! participation (14% of 148,963 MOVE! participants, regardless of mental health status)...
November 1, 2014: Psychiatric Services: a Journal of the American Psychiatric Association
R E Goldstein, C Brovida, M J Fernández-Del Palacio, M P Littman, D J Polzin, A Zatelli, L D Cowgill
No abstract text is available yet for this article.
November 2013: Journal of Veterinary Internal Medicine
John S Barbieri, Caroline A Nelson, William D James, David J Margolis, Ryan Littman-Quinn, Carrie L Kovarik, Misha Rosenbach
IMPORTANCE: Many hospitals do not have inpatient dermatologic consultative services, and most have reduced availability of services during off-hours. Dermatologists based in outpatient settings can find it challenging to determine the urgency with which they need to evaluate inpatients when consultations are requested. Teledermatology may provide a valuable mechanism for dermatologists to triage inpatient consultations and increase efficiency, thereby expanding access to specialized care for hospitalized patients...
April 2014: JAMA Dermatology
Sohela Shah, Kasmintan A Schrader, Esmé Waanders, Andrew E Timms, Joseph Vijai, Cornelius Miething, Jeremy Wechsler, Jun Yang, James Hayes, Robert J Klein, Jinghui Zhang, Lei Wei, Gang Wu, Michael Rusch, Panduka Nagahawatte, Jing Ma, Shann-Ching Chen, Guangchun Song, Jinjun Cheng, Paul Meyers, Deepa Bhojwani, Suresh Jhanwar, Peter Maslak, Martin Fleisher, Jason Littman, Lily Offit, Rohini Rau-Murthy, Megan Harlan Fleischut, Marina Corines, Rajmohan Murali, Xiaoni Gao, Christopher Manschreck, Thomas Kitzing, Vundavalli V Murty, Susana C Raimondi, Roland P Kuiper, Annet Simons, Joshua D Schiffman, Kenan Onel, Sharon E Plon, David A Wheeler, Deborah Ritter, David S Ziegler, Kathy Tucker, Rosemary Sutton, Georgia Chenevix-Trench, Jun Li, David G Huntsman, Samantha Hansford, Janine Senz, Tom Walsh, Ming Lee, Christopher N Hahn, Kathryn G Roberts, Mary-Claire King, Sarah M Lo, Ross L Levine, Agnes Viale, Nicholas D Socci, Katherine L Nathanson, Hamish S Scott, Mark Daly, Steven M Lipkin, Scott W Lowe, James R Downing, David Altshuler, John T Sandlund, Marshall S Horwitz, Charles G Mullighan, Kenneth Offit
Somatic alterations of the lymphoid transcription factor gene PAX5 (also known as BSAP) are a hallmark of B cell precursor acute lymphoblastic leukemia (B-ALL), but inherited mutations of PAX5 have not previously been described. Here we report a new heterozygous germline variant, c.547G>A (p.Gly183Ser), affecting the octapeptide domain of PAX5 that was found to segregate with disease in two unrelated kindreds with autosomal dominant B-ALL. Leukemic cells from all affected individuals in both families exhibited 9p deletion, with loss of heterozygosity and retention of the mutant PAX5 allele at 9p13...
October 2013: Nature Genetics
Hiroki Torikai, Andreas Reik, Frank Soldner, Edus H Warren, Carrie Yuen, Yuanyue Zhou, Denise L Crossland, Helen Huls, Nicholas Littman, Ziying Zhang, Scott S Tykodi, Partow Kebriaei, Dean A Lee, Jeffrey C Miller, Edward J Rebar, Michael C Holmes, Rudolf Jaenisch, Richard E Champlin, Philip D Gregory, Laurence J N Cooper
Long-term engraftment of allogeneic cells necessitates eluding immune-mediated rejection, which is currently achieved by matching for human leukocyte antigen (HLA) expression, immunosuppression, and/or delivery of donor-derived cells to sanctuary sites. Genetic engineering provides an alternative approach to avoid clearance of cells that are recognized as "non-self" by the recipient. To this end, we developed designer zinc finger nucleases and employed a "hit-and-run" approach to genetic editing for selective elimination of HLA expression...
August 22, 2013: Blood
Jonathan Massey, Alisdair Boag, Andrea D Short, Rachel A Scholey, Paula S Henthorn, Meryl P Littman, Eystein Husebye, Brian Catchpole, Niels Pedersen, Cathryn S Mellersh, William E R Ollier, Lorna J Kennedy
Canine hypoadrenocorticism is an endocrine disorder characterised by inadequate secretion of steroid hormones from the adrenal glands. Pathology results from immune-mediated destruction of the adrenal cortex, which is similar to that seen in the human Addison's disease. Both the canine and human diseases have similar clinical presentation, with the diagnosis based on performing a dynamic adrenocorticotropic hormone stimulation test. MHC class II has previously been associated with the human and canine diseases...
April 2013: Immunogenetics
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