keyword
MENU ▼
Read by QxMD icon Read
search

Glucose critically

keyword
https://www.readbyqxmd.com/read/29474506/derivation-of-outcome-based-pediatric-critical-values
#1
Hao Du, Corey Markus, Michael Metz, Mengling Feng, Tze Ping Loh
Objectives: There is currently a lack of an outcomes-based definition of critical values for the pediatric population. This has contributed to a highly heterogeneous critical value reporting practice between laboratories. Methods: Anonymized results were extracted from a laboratory information system for 10 biochemistry tests. The probability of high-dependency/intensive care unit admission (as a proxy for adverse outcomes) for each individual laboratory concentration was calculated and adjusted to fit using a polynomial function to model the probability trend...
February 21, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29473524/pharmacogenetics-of-glucagon-like-peptide-1-agonists-for-the-treatment-of-type-2-diabetes-mellitus
#2
Spyridon Karras, Eleni Rapti, Theocharis Koufakis, Angeliki Kyriazou, Dimitrios Goulis, Kalliopi Kotsa
BACKGROUND: Pharmacogenetics is a promising area of medical research, providing methods to identify the appropriate pharmaceutical agent and dosing for each unique patient. Glucagon-like peptide-1 (GLP-1) agonists are a novel therapeutic choice used in the treatment of type 2 diabetes mellitus (T2DM), demonstrating efficacy regarding glycemic control and weight loss. Therapeutic response to GLP-1 agonist treatment is a complex biophenomenon, dependent on a plethora of modifiable (diet, exercise, adherence) and non-modifiable (genetic individual variants, ethnic characteristics) parameters...
February 21, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29471267/the-effectiveness-of-traditional-chinese-medicine-based-lifestyle-interventions-on-biomedical-psychosocial-and-behavioral-outcomes-in-individuals-with-type-2-diabetes-a-systematic-review-with-meta-analysis
#3
REVIEW
Xingfeng Yu, Janita P C Chau, Lanting Huo
BACKGROUND: Integrative diabetes care, which combines conventional diabetes therapy with traditional Chinese medicine (TCM)-based interventions, has gained popularity worldwide. Numerous TCM-based lifestyle modification approaches have been proposed for individuals with type 2 diabetes (T2DM). OBJECTIVES: To synthesize and present the best available evidence on the effectiveness of TCM-based lifestyle interventions in individuals with T2DM. DESIGN: We undertook a systematic review of randomized controlled trials or controlled clinical trials...
February 19, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29467782/las%C3%AE-5315-effector-induces-extreme-starch-accumulation-and-chlorosis-as-ca-liberibacter-asiaticus-infection-in-nicotiana-benthamiana
#4
Marco Pitino, Victoria Allen, Yongping Duan
Huanglongbing (HLB), a destructive plant bacterial disease, severely impedes worldwide citrus production. HLB is associated with a phloem-limited α-proteobacterium, Candidatus Liberibacter asiaticus (Las). Las infection causes yellow shoots and blotchy mottle on leaves and is associated with excessive starch accumulation. However, the mechanisms underlying the starch accumulation remain unknown. We previously showed that the Las5315mp effector induced callose deposition and cell death in Nicotiana benthamiana ...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29467286/viral-insulin-like-peptides-activate-human-insulin-and-igf-1-receptor-signaling-a-paradigm-shift-for-host-microbe-interactions
#5
Emrah Altindis, Weikang Cai, Masaji Sakaguchi, Fa Zhang, Wang GuoXiao, Fa Liu, Pierre De Meyts, Vasily Gelfanov, Hui Pan, Richard DiMarchi, C Ronald Kahn
Viruses are the most abundant biological entities and carry a wide variety of genetic material, including the ability to encode host-like proteins. Here we show that viruses carry sequences with significant homology to several human peptide hormones including insulin, insulin-like growth factors (IGF)-1 and -2, FGF-19 and -21, endothelin-1, inhibin, adiponectin, and resistin. Among the strongest homologies were those for four viral insulin/IGF-1-like peptides (VILPs), each encoded by a different member of the family Iridoviridae VILPs show up to 50% homology to human insulin/IGF-1, contain all critical cysteine residues, and are predicted to form similar 3D structures...
February 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29467247/fat-body-glycogen-serves-as-a-metabolic-safeguard-for-the-maintenance-of-sugar-levels-in-drosophila
#6
Takayuki Yamada, Okiko Habara, Hitomi Kubo, Takashi Nishimura
Adapting to changes in food availability is a central challenge for survival. Glucose is an important resource for energy production, and therefore, many organisms synthesize and retain sugar storage molecules. In insects, glucose is stored in two different forms: the disaccharide trehalose and the branched polymer glycogen. Glycogen is synthesized and stored in several tissues, including in muscle and the fat body. Despite the important role of the fat body as a center for energy metabolism, the importance of its glycogen content remains unclear...
February 21, 2018: Development
https://www.readbyqxmd.com/read/29465311/p32-regulates-er-stress-and-lipid-homeostasis-by-down-regulating-gcs1-expression
#7
Yong Liu, Patrick L Leslie, Aiwen Jin, Koji Itahana, Lee M Graves, Yanping Zhang
Sustained endoplasmic reticulum (ER) stress plays a major role in the development of many metabolic diseases, including cardiovascular disease, nonalcoholic fatty liver disease, insulin resistance, obesity, and diabetes. p32 is a multicompartmental protein involved in the regulation of oxidative phosphorylation and glucose oxidation. p32 ablation is associated with resistance to age-associated and diet-induced obesity through a mechanism that remains largely unknown. Here, we show that p32 promotes lipid biosynthesis by modulating fatty acid-induced ER stress...
February 20, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29463248/lactate-promotes-specific-differentiation-in-bovine-granulosa-cells-depending-on-lactate-uptake-thus-mimicking-an-early-post-lh-stage
#8
Anja Baufeld, Jens Vanselow
BACKGROUND: The LH-induced folliculo-luteal transformation is connected with alterations of the gene expression profile in cells of the granulosa layer. It has been described that hypoxic conditions occur during luteinization, thus favoring the formation of L-lactate within the follicle. Despite being a product of anaerobic respiration, L-lactate has been shown to act as a signaling molecule affecting gene expression in neuronal cells. During the present study, we tested the hypothesis that L-lactate may influence differentiation of follicular granulosa cells (GC)...
February 20, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29461333/metabolic-syndrome-among-asian-indians-in-the-united-states
#9
Sanghamitra S Savadatti, Erin M Bell, Margaret A Gates, Akiko S Hosler, Recai M Yucel, Ranjita Misra
INTRODUCTION: Metabolic syndrome (MetS), a clustering of cardiometabolic risk factors of type 2 diabetes and cardiovascular disease, disproportionately affects Asian Indians (AIs). We examined prevalence of MetS using 3 ethnicity-specific MetS criteria among immigrant AIs in the United States. We also examined associations between MetS and health promotion behaviors. OBJECTIVE: To present MetS prevalence estimates by the 3 ethnicity-specific criteria and investigate differences in health promotion behaviors among AIs with and without MetS to highlight the critical need for lifestyle modification strategies for this population...
February 14, 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29461272/does-aerobic-respiration-produce-carbon-dioxide-or-hydrogen-ion-and-bicarbonate
#10
Erik R Swenson
Maintenance of intracellular pH is critical for clinical homeostasis. The metabolism of glucose, fatty acids, and amino acids yielding the generation of adenosine triphosphate in the mitochondria is accompanied by the production of acid in the Krebs cycle. Both the nature of this acidosis and the mechanism of its disposal have been argued by two investigators with a long-abiding interest in acid-base physiology. They offer different interpretations and views of the molecular mechanism of this intracellular pH regulation during normal metabolism...
February 15, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29459791/different-enteral-nutrition-formulas-have-no-effect-on-glucose-homeostasis-but-on-diet-induced-thermogenesis-in-critically-ill-medical-patients-a-randomized-controlled-trial
#11
Marlene Wewalka, Andreas Drolz, Berit Seeland, Mathias Schneeweiss, Monika Schmid, Bruno Schneeweiss, Christian Zauner
BACKGROUND/OBJECTIVES: Hyperglycemia is common in critically ill patients and associated with increased mortality. It has been suggested that different nutrition formulas may beneficially influence glucose levels in surgical intensive care patients. In this prospective randomized clinical cohort study we investigated glucose homeostasis in response to different enteral nutrition formulas in medical critically ill patients. SUBJECTS/METHODS: 60 medical critically ill patients were randomized to receive continuous fat-based (group A, n = 30) or glucose-based enteral nutrition (group B, n = 30) for seven days...
February 19, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29459250/adipose-specific-disruption-of-seipin-causes-early-onset-generalised-lipodystrophy-and-altered-fuel-utilisation-without-severe-metabolic-disease
#12
George D Mcilroy, Karla Suchacki, Anke J Roelofs, Wulin Yang, Yanyun Fu, Bo Bai, Robert J Wallace, Cosimo De Bari, William P Cawthorn, Weiping Han, Mirela Delibegović, Justin J Rochford
OBJECTIVE: Mutations to the BSCL2 gene disrupt the protein seipin and cause the most severe form of congenital generalised lipodystrophy (CGL). Affected individuals exhibit a near complete loss of white adipose tissue (WAT) and suffer from metabolic disease. Seipin is critical for adipocyte development in culture and mice with germline disruption to Bscl2 recapitulate the effects of BSCL2 disruption in humans. Here we examined whether loss of Bscl2 specifically in developing adipocytes in vivo is sufficient to prevent adipose tissue development and cause all features observed with congenital BSCL2 disruption...
January 31, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29458148/untimely-oxidative-stress-in-%C3%AE-cells-leads-to-diabetes-role-of-circadian-clock-in-%C3%AE-cell-function
#13
REVIEW
J Lee, K Ma, M Moulik, V Yechoor
Diabetes results from a loss of β-cell function. With the number of people with diabetes reaching epidemic proportions globally, understanding mechanisms that are contributing to this increasing prevalence is critical. One such factor has been circadian disruption, with shift-work, light pollution, jet-lag, increased screen time, all acting as potential contributory factors. Though circadian disruption has been epidemiologically associated with diabetes and other metabolic disorders for many decades, it is only recently that there has been a better understanding of the underlying molecular mechanisms...
February 16, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29457786/intracellular-lipid-metabolism-impairs-%C3%AE-cell-compensation-during-diet-induced-obesity
#14
Risheng Ye, Ruth Gordillo, Mengle Shao, Toshiharu Onodera, Zhe Chen, Shiuhwei Chen, Xiaoli Lin, Jeffrey A SoRelle, Xiaohong Li, Miao Tang, Mark P Keller, Regina Kuliawat, Alan D Attie, Rana K Gupta, William L Holland, Bruce Beutler, Joachim Herz, Philipp E Scherer
The compensatory proliferation of insulin-producing β cells is critical to maintaining glucose homeostasis at the early stage of type 2 diabetes. Failure of β cells to proliferate results in hyperglycemia and insulin dependence in patients. To understand the effect of the interplay between β cell compensation and lipid metabolism upon obesity and peripheral insulin resistance, we eliminated LDL receptor-related protein 1 (LRP1), a pleiotropic mediator of cholesterol, insulin, energy metabolism, and other cellular processes, in β cells...
February 19, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29454073/the-accumulation-of-assembly-intermediates-of-the-mitochondrial-complex-i-matrix-arm-is-reduced-by-limiting-glucose-uptake-in-a-neuronal-like-model-of-melas-syndrome
#15
Guillaume Geffroy, Rayane Benyahia, Samuel Frey, Valerie Desquiret-Dumas, Naig Gueguen, Celine Bris, Sophie Belal, Aurore Inisan, Aurelie Renaud, Arnaud Chevrollier, Daniel Henrion, Dominique Bonneau, Franck Letournel, Guy Lenaers, Pascal Reynier, Vincent Procaccio
Ketogenic diet (KD) which combined carbohydrate restriction and the addition of ketone bodies has emerged as an alternative metabolic intervention used as an anticonvulsant therapy or to treat different types of neurological or mitochondrial disorders including MELAS syndrome. MELAS syndrome is a severe mitochondrial disease mainly due to the m.3243A > G mitochondrial DNA mutation. The broad success of KD is due to multiple beneficial mechanisms with distinct effects of very low carbohydrates and ketones...
February 14, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29451831/high-dose-perinatal-folic-acid-supplementation-alters-insulin-sensitivity-in-sprague-dawley-rats-and-diminishes-the-expression-of-adiponectin
#16
Ayodele Olufemi Morakinyo, Titilola Aderonke Samuel, Funmileyi Olubajo Awobajo, Gabriel Olorunleke Oludare, Adekunle Mofolorunso
The possible intake of folate in excess of the recommended upper levels is a matter of critical importance. This study was conducted to investigate the effects of prenatal and postnatal high folic acid supplementation (FAS) on glucose tolerance, insulin sensitivity, lipid metabolism, and expression of adiponectin in rats. The study included 20 female rats divided into two groups: control group and FAS group (receiving high folic acid supplemented diet). Both groups of female rats were mated and pregnancy confirmed...
February 16, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29451713/glucose-effectiveness-is-a-critical-pathogenic-factor-leading-to-the-emergence-of-glucose-intolerance-and-type-2-diabetes-mellitus-an-ignored-hypothesis
#17
F P Alford, J E Henriksen, C Rantzau, H Beck-Nielsen
BACKGROUND: Although the ability of glucose to mediate its own in vivo metabolism is long documented, the quantitative measurement of whole body glucose-mediated glucose disposal at basal insulin levels, [glucose effectiveness (GE)], followed the introduction of the Minimal Model IVGTT technique. METHODS: A literature review, combined with our own studies, of the role of GE in glucose metabolism in normal and "at risk" individuals, was undertaken to determine GE's contribution to glucose homeostasis...
February 16, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29449542/long-non-coding-rnas-in-ischemic-stroke
#18
REVIEW
Mei-Hua Bao, Vivian Szeto, Burton B Yang, Shu-Zhen Zhu, Hong-Shuo Sun, Zhong-Ping Feng
Stroke is one of the leading causes of mortality and disability worldwide. Uncovering the cellular and molecular pathophysiological processes in stroke have been a top priority. Long non-coding (lnc) RNAs play critical roles in different kinds of diseases. In recent years, a bulk of aberrantly expressed lncRNAs have been screened out in ischemic stroke patients or ischemia insulted animals using new technologies such as RNA-seq, deep sequencing, and microarrays. Nine specific lncRNAs, antisense non-coding RNA in the INK4 locus (ANRIL), metastasis-associate lung adenocarcinoma transcript 1 (MALAT1), N1LR, maternally expressed gene 3 (MEG3), H19, CaMK2D-associated transcript 1 (C2dat1), Fos downstream transcript (FosDT), small nucleolar RNA host gene 14 (SNHG14), and taurine-upregulated gene 1 (TUG1), were found increased in cerebral ischemic animals and/or oxygen-glucose deprived (OGD) cells...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29447763/scaling-of-bony-canals-for-encephalic-vessels-in-euarchontans-implications-for-the-role-of-the-vertebral-artery-and-brain-metabolism
#19
Doug M Boyer, Arianna R Harrington
Supplying the central nervous system with oxygen and glucose for metabolic activities is a critical function for all animals at physiologic, anatomical, and behavioral levels. A relatively proximate challenge to nourishing the brain is maintaining adequate blood flow. Euarchontans (primates, dermopterans and treeshrews) display a diversity of solutions to this challenge. Although the vertebral artery is a major encephalic vessel, previous research has questioned its importance for irrigating the cerebrum. This presents a puzzling scenario for certain strepsirrhine primates (non-cheirogaleid lemuriforms) that have reduced promontorial branches of the internal carotid artery and no apparent alternative encephalic vascular route except for the vertebral artery...
January 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29444711/information-needs-in-people-with-diabetes-mellitus-a-systematic-review
#20
Lisa Biernatzki, Silke Kuske, Jutta Genz, Michaela Ritschel, Astrid Stephan, Christina Bächle, Sigrid Droste, Sandra Grobosch, Nicole Ernstmann, Nadja Chernyak, Andrea Icks
BACKGROUND: The purpose of this study was to identify and analyse currently available knowledge on information needs of people with diabetes mellitus, also considering possible differences between subgroups and associated factors. METHODS: Twelve databases including MEDLINE, EMBASE and the Cochrane Library were searched up until June 2015. Publications that addressed self-reported information needs of people with diabetes mellitus were included. Each study was assessed by using critical appraisal tools, e...
February 14, 2018: Systematic Reviews
keyword
keyword
22568
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"