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https://www.readbyqxmd.com/read/28718774/effects-of-microchannel-confinement-on-acoustic-vaporisation-of-ultrasound-phase-change-contrast-agents
#1
Shengtao Lin, Ge Zhang, Chee Hau Leow, Meng-Xing Tang
The sub-micron phase change contrast agent (PCCA) composed of a perfluorocarbon liquid core can be activated into gaseous state and form stable echogenic microbubbles for contrast-enhanced ultrasound imaging. It has shown great promises in imaging microvasculature, tumour microenvironment, and cancer cells. Although PCCAs have been extensively studied for different diagnostic and therapeutic applications, the effect of biologically geometrical confinement on the acoustic vaporisation of PCCAs is still not clear...
July 18, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28718667/hydroxytyrosol-induces-apoptosis-and-cell-cycle-arrest-and-suppresses-multiple-oncogenic-signaling-pathways-in-prostate-cancer-cells
#2
Haseeb Zubair, Arun Bhardwaj, Aamir Ahmad, Sanjeev Kumar Srivastava, Mohammad Aslam Khan, Girijesh Kumar Patel, Seema Singh, Ajay Partap Singh
SCOPE: Hydroxytyrosol (HT), a polyphenol from olives, is a potential anticancer agent. This study was designed to evaluate the anticancer activity of HT against prostate cancer cells, and the mechanism thereof. METHODS AND RESULTS: Treatment of LNCaP and C4-2 prostate cancer cells with HT resulted in a dose-dependent inhibition of proliferation. This was in contrast to HT's ineffectiveness against normal prostate epithelial cells RWPE1 and PWLE2, suggesting cancer-cell-specific effect...
July 18, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28718042/contrast-enhanced-ultrasound-for-focal-liver-lesions-how-accurate-is-it
#3
Richard G Barr
With the recent FDA approval for characterization of focal liver lesions (FLL) in both pediatric and adult patients using Lumason (sulfur hexafluoride microbubbles), increased use of ultrasound contrast for routine clinical use is expected. This agent has been available for many years in Europe and Asia, and a large body of literature is available regarding the sensitivity and specificity of this agent. In addition, a few studies have directly compared CEUS to CECT and CEMRI for the characterization of focal liver lesions...
July 17, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28717229/investigation-of-autistic-traits-through-strategic-decision-making-in-games-with-adaptive-agents
#4
Alexis B Craig, Emily Grossman, Jeffrey L Krichmar
Autism Spectrum Disorders are characterized by difficulties in communicating and cooperating with other people. Impairment in Theory of Mind (ToM), the ability to infer what another person is thinking, may contribute to these social deficits. The present study assesses the relationship between autistic traits and decision-making in a socioeconomic game environment that measures ToM and cooperation. We quantified participant strategy during game play with computer agents that simulated aspects of ToM or fixed strategy agents with static behaviors or heuristics...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717193/adhesive-capsulitis-of-the-shoulder-evaluation-with-us-arthrography-using-a-sonographic-contrast-agent
#5
Xueqing Cheng, Zhenqi Zhang, Guo Xuanyan, Tingting Li, Juan Li, Longlin Yin, Man Lu
Adhesive capsulitis (AC) is a painful and disabling disorder, which caused restricted motion and chronic pain of shoulder. Intracavitary contrast-enhanced ultrasound has been recently applied to assess obstructive bile duct diseases, tubal patency, vesicoureteric reflux and so on. The aim of this study was to detect the value of US-arthrography by injecting the contrast agent SonoVue into glenohumeral joint compared with US in diagnosing AC. Utrasound (US) and US-arthrography images of 45 patients with AC were compared with that of 45 control subjects without AC with MRI as a gold standard...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716954/synaptically-driven-phosphorylation-of-ribosomal-protein-s6-is-differentially-regulated-at-active-synapses-versus-dendrites-and-cell-bodies-by-mapk-and-pi3k-mtor-signaling-pathways
#6
Patricia Salgado Pirbhoy, Shannon Farris, Oswald Steward
High-frequency stimulation of the medial perforant path triggers robust phosphorylation of ribosomal protein S6 (rpS6) in activated dendritic domains and granule cell bodies. Here we dissect the signaling pathways responsible for synaptically driven rpS6 phosphorylation in the dentate gyrus using pharmacological agents to inhibit PI3-kinase/mTOR and MAPK/ERK-dependent kinases. Using phospho-specific antibodies for rpS6 at different sites (ser235/236 versus ser240/244), we show that delivery of the PI3-kinase inhibitor, wortmannin, decreased rpS6 phosphorylation throughout the somatodendritic compartment (granule cell layer, inner molecular layer, outer molecular layer), especially in granule cell bodies while sparing phosphorylation at activated synapses (middle molecular layer)...
August 2017: Learning & Memory
https://www.readbyqxmd.com/read/28715761/effects-of-lead-mineralogy-on-soil-washing-enhanced-by-ferric-salts-as-extracting-and-oxidizing-agents
#7
Jong-Chan Yoo, Sang-Min Park, Geun-Seok Yoon, Daniel C W Tsang, Kitae Baek
In this study, we evaluated the feasibility of using ferric salts including FeCl3 and Fe(NO3)3 as extracting and oxidizing agents for a soil washing process to remediate Pb-contaminated soils. We treated various Pb minerals including PbO, PbCO3, Pb3(CO3)2(OH)2, PbSO4, PbS, and Pb5(PO4)3(OH) using ferric salts, and compared our results with those obtained using common washing agents of HCl, HNO3, disodium-ethylenediaminetetra-acetic acid (Na2-EDTA), and citric acid. The use of 50 mM Fe(NO3)3 extracted significantly more Pb (above 96% extraction) from Pb minerals except PbSO4 (below 55% extraction) compared to the other washing agents...
July 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28715316/virtual-humans-for-implantable-device-safety-assessment-in-mri-mitigating-magnetic-resonance-imaging-hazards-for-implanted-medical-devices
#8
James E Brown, Rui Qiang, Paul J Stadnik, Larry J Stotts, Jeffrey A Von Arx
Magnetic resonance imaging (MRI) is the preferred modality for soft tissue imaging because of its nonionizing radiation and lack of contrast agent. Due to interactions between the MR system and active implantable medical devices (AIMDs), patients with implants such as pacemakers are generally denied access to MRI, which presents a detriment to that population. It has been estimated that 50-75% of patients with a cardiac device were denied access to MRI scanning and, moreover, that 17% of pacemaker patients need an MRI within 12 months of implantation [1]...
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28713885/synergistic-effect-of-au-ag-nano-alloying-intense-seira-and-enhanced-catalysis
#9
Manoj Verma, M Boazbou Newmai, P Senthil Kumar
The well-known AuAg nanohybrid system was effectively synthesized, utilizing polyvinyl pyrrolidone (PVP) as a multiple metal precursor reducing agent (based solely on their reduction potentials), thereby drastically decreasing their activation energy of diffusion and readily facilitating the homogenous alloy nanoparticle formation, duly confirmed by Vegard's law. Furthermore, the crucial parameters in determining the local electric field enhancement in the vicinity of the alloy nanoparticles such as the quality factor Q, dephasing time, T2 and the homogenous line width Γ were also evaluated in a systematic manner, in correlation with their unique visible optical absorption spectra...
July 17, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28713577/seroprevalence-of-spotted-fever-group-sfg-rickettsiae-infection-in-domestic-ruminants-in-khartoum-state-sudan
#10
Nagwa M Eisawi, Dina A Hassan, Mohammed O Hussien, Azza B Musa, Abdel Rahim M El Hussein
Spotted fever group (SFG) rickettsiosis is caused by obligatory intracellular Gram-negative bacteria that belong to the genus Rickettsia. Ticks belonging to the family Ixodidae can act as vectors, reservoirs or amplifiers of SFG rickettsiae. This study was conducted to estimate the seroprevalence of SFG rickettsioses in cattle, sheep and goats from Khartoum State, Sudan. Blood samples were collected from a total of 600 animals (sheep, goats and cattle) from 32 different farms distributed in three locations in Khartoum State during the period January to December 2012...
May 2017: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/28713357/extensively-drug-resistant-klebsiella-pneumoniae-causing-nosocomial-bloodstream-infections-in-china-molecular-investigation-of-antibiotic-resistance-determinants-informing-therapy-and-clinical-outcomes
#11
Wenzi Bi, Haiyang Liu, Rhys A Dunstan, Bin Li, Von Vergel L Torres, Jianming Cao, Lijiang Chen, Jonathan J Wilksch, Richard A Strugnell, Trevor Lithgow, Tieli Zhou
The rise in diversity of antimicrobial resistance phenotypes seen in Klebsiella pneumoniae is becoming a serious antibiotic management problem. We sought to investigate the molecular characteristics and clinical implications of extensively drug-resistant (XDR) K. pneumoniae isolated from different nosocomial bloodstream infections (BSIs) patients from July 2013 to November 2015. Even in combination treatment, meropenem did not protect against mortality of BSIs patients (P = 0.015). In contrast, tigecycline in combination with other antimicrobial agents significantly protected against mortality (P = 0...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28712788/antimalarial-agent-artesunate-protects-concanavalin-a-induced-autoimmune-hepatitis-in-mice-by-inhibiting-inflammatory-responses
#12
Xin Zhao, MingJiang Liu, JinGui Li, ShaoJie Yin, YangYang Wu, AnYuan Wang
The anti-malarial drug artesunate (ARS) has been shown to possess anti-inflammatory activity. Its effect on autoimmune hepatitis remains unclear. Concanavalin A (Con A)-induced hepatitis was used in this study to reveal the potential action of ARS and the related mechanism. Mice were pretreated with ARS followed by Con A challenge. Con A caused obvious hepatic injury with higher levels of liver enzymes, elevated pro-inflammatory cytokines and activation of nuclear factor-κB (NF-κB) and mitogen activated protein kinase (MAPK) signaling pathways...
July 13, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28712740/aspects-of-adhesion-tests-on-resin-glass-ceramic-bonding
#13
Andrew Chi Ho Wong, Tian Tian, James Kit Hon Tsoi, Michael Francis Burrow, Jukka Pekka Matinlinna
OBJECTIVES: This study aimed to compare and contrast two resin-ceramic bond strength tests, the tensile bond strength and the four-point bending tests. The effects of hydrofluoric acid (HF) etching time and storage condition on bond strength were also studied. METHODS: Ceramic beams (N=480) with the dimensions of 2.00×2.00×12.45mm(3) were sectioned from lithium disilicate ceramic ingots (IPS e.max CAD), then polished and fired for final crystallization. The joint surfaces were etched with HF gel (IPS Ceramic etching gel) for 20s, 40s, or 60s of each group (n=160)...
July 13, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28711538/cerebral-venous-sinus-thrombosis-secondary-to-idiopathic-hypertrophic-cranial-pachymeningitis-a-case-report-and-review-of-the-literature
#14
Kaiyuan Huang, Qingsheng Xu, Yuankun Ma, Renya Zhan, Jian Shen, Jianwei Pan
BACKGOUND AND IMPORTANCE: Idiopathic hypertrophic cranial pachymeningitis (IHCP) is a rare fibrosing inflammatory process involving the dura mater. Currently, there is no consensus on the treatments for IHCP, and the usefulness of immunosuppressive agents as a first-line option remains controversial. Cerebral venous sinus occlusion (CVSO) and cerebral venous sinus thrombosis (CVST) secondary to IHCP, which may cause progressive intracranial hypertension and venous obstructive parenchymal lesions, make the diagnosis and treatment of IHCP more complicated...
July 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28711443/regional-distribution-of-pulmonary-blood-volume-with-dual-energy-computed-tomography-results-in-42-subjects
#15
Paul Felloni, Alain Duhamel, Jean-Baptiste Faivre, Jessica Giordano, Suonita Khung, Valérie Deken, Jacques Remy, Martine Remy-Jardin
RATIONALE AND OBJECTIVES: The noninvasive approach of lung perfusion generated from dual-energy computed tomography acquisitions has entered clinical practice. The purpose of this study was to analyze the regional distribution of iodine within distal portions of the pulmonary arterial bed on dual-source, dual-energy computed tomography examinations in a cohort of subjects without cardiopulmonary pathologies. MATERIALS AND METHODS: The study population included 42 patients without cardiorespiratory disease, enabling quantitative and qualitative analysis of pulmonary blood volume after administration of a 40% contrast agent...
July 12, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28709019/biocompatible-pegylated-bismuth-nanocrystals-all-in-one-theranostic-agent-with-triple-modal-imaging-and-efficient-in%C3%A2-vivo-photothermal-ablation-of-tumors
#16
Zhenglin Li, Jing Liu, Ying Hu, Zhuo Li, Xuelei Fan, Ye Sun, Flemming Besenbacher, Chunying Chen, Miao Yu
Biocompatible single-component theranostic agents integrating multimodal imaging and therapeutic functions (namely, "all-in one" agents) are highly desired for clinical cancer treatments. Herein, PEGylated pure metallic bismuth nanocrystals (Bi-PEG NCs) have been developed to be a competent theranostic agent for in vivo high-performance multimodal bio-imaging and photothermal ablation of tumors. The resultant Bi-PEG NCs show excellent physiological stability, biocompatibility, prolonged blood circulation half-life and preferential tumor accumulation...
June 23, 2017: Biomaterials
https://www.readbyqxmd.com/read/28708938/interactions-between-quinolones-and-bacillus-anthracis-gyrase-and-the-basis-of-drug-resistance
#17
Rachel E Ashley, Robert Hunter Lindsey, Sylvia A McPherson, Charles L Turnbough, Robert J Kerns, Neil Osheroff
Gyrase appears to be the primary cellular target for quinolone antibacterials in multiple pathogenic bacteria, including Bacillus anthracis, the causative agent of anthrax. Given the significance of this type II topoisomerase as a drug target, it is critical to understand how quinolones interact with gyrase and how specific mutations lead to resistance. However, these important issues have yet to be addressed for a canonical gyrase. Therefore, we utilized a mechanistic approach to characterize quinolone interactions with wild-type B...
July 14, 2017: Biochemistry
https://www.readbyqxmd.com/read/28708734/t2-correction-in-dynamic-contrast-enhanced-magnetic-resonance-imaging-of-glioblastoma-from-a-half-dose-of-high-relaxivity-contrast-agent
#18
Silvano Filice, Girolamo Crisi, Gunter Erb
OBJECTIVE: The aim of this study was to evaluate the arterial input function (AIF) and tissue enhancement time curve (tissue function [TF]) obtained after the administration of a half-dose gadobenate dimeglumine (0.05-mmol/kg body weight [bw]) compared with a full dose (0.1-mmol/kg bw) of a standard-relaxivity contrast agent. METHODS: We enrolled 40 adult patients with glioblastoma in an interindividual comparative study. Patients were randomized to 1 of the 2 study arms: 20 patients received 0...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28708716/the-influence-of-contrast-agent-s-osmolarity-on-iodine-delivery-protocol-in-coronary-computed-tomography-angiography-comparison-between-iso-osmolar-iodixanol-320-and-low-osmolar-iomeprol-370
#19
Xiaohan Yang, Weiwei Huang, Wangyan Liu, Yinsu Zhu, Yi Xu, Guanyu Yang, Lijun Tang, Xiaomei Zhu
OBJECTIVES: This study aims to assess whether iodine-contained contrast agents with different osmolarity affect iodine delivery protocol during coronary computed tomography angiography (CCTA). METHODS: Patients who underwent CCTA were randomized to receive contrast media either iodixanol-320 (iso-osmolar group) or iopromide-370 (low-osmolar group). Contrast protocols were recorded. Tube voltage of 100 kV was chosen for patients with body mass index of less than or equal to 25 (n = 224) and tube voltage of 120 kV for patients with body mass index of greater than 25 (n = 165)...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28707958/gadofosveset-enhanced-thoracic-mr-venography-a-comparative-study-evaluating-steady-state-imaging-versus-conventional-first-pass-time-resolved-dynamic-imaging
#20
Teik C See, Andrew J Patterson, Nicholas J Hilliard, Ed Soh, Andrew P Winterbottom, Ilse Patterson, Richard A Parker, Martin J Graves, David J Lomas
Background Dedicated blood-pool contrast agents combined with optimal angiographic protocols could improve the diagnostic accuracy of thoracic magnetic resonance angiography (MRA). Purpose To assess the clinical utility of Gadofesveset-enhanced imaging and compare an optimized steady-state (SS) sequence against conventional first-pass dynamic multi-phase (DMP) imaging. Material and Methods Twenty-nine patients (17 men, 12 women; mean age = 42.7, age range = 18-72 years) referred for MR thoracic venography were recruited...
January 1, 2017: Acta Radiologica
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