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https://www.readbyqxmd.com/read/29045272/palliative-nursing-for-cancer-patients-as-an-abstract-concept-a-hermeneutic-study
#1
Leili Borimnejad, Marjan Mardani-Hamooleh, Naimeh Seyedfatemi, Mamak Tahmasebi
BACKGROUND: Understanding the outcomes of palliative care (PC) that is provided to patients with cancer is necessary. PURPOSE: The aim of this study was to explore the lived experiences of Iranian nurses with regard to PC outcomes in cancer patients. METHODS: This hermeneutic study interviewed 14 nurses to understand their lived experiences with regard to PC outcomes in cancer patients. A seven-stage process of data analysis was employed. RESULTS: One constitutive pattern "palliative nursing for cancer patients is an abstractive concept" and the two associated themes of "providing excellent PC" and "PC as an alarm" were identified...
October 18, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/29045241/taking-assent-to-new-heights-a-case-report-on-do-not-resuscitate-status-in-pediatric-palliative-care-procedures
#2
Heather A Ballard, Santhanam Suresh
Dying adolescents presenting for palliative procedures have complicated developmental and ethical issues, especially when reconsidering do-not-resuscitate orders. Though the American Academy of Pediatrics has guidelines, there is limited information in the literature on how to take care of these patients. We describe the case of a 14-year-old patient presenting to the interventional radiology suite for management of superior vena cava syndrome. The patient's goals of treatment were elucidated through a comprehensive care team consisting of the procedural and oncology teams...
October 17, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29044941/clinical-significance-of-changes-in-systemic-inflammatory-markers-and-carcinoembryonic-antigen-levels-in-predicting-metastatic-colorectal-cancer-prognosis-and-chemotherapy-response
#3
In-Ho Kim, Ji Eun Lee, Ji Hyun Yang, Joon Won Jeong, Sangmi Ro, Myung Ah Lee
AIM: Metastatic colorectal cancer (mCRC) is associated with poor prognosis, and biomarkers are required for predicting survival and chemotherapy response. This study aimed to evaluate the significance of changes in systemic inflammatory markers and carcinoembryonic antigen (CEA) levels in predicting mCRC prognosis and chemotherapy response. METHODS: In this retrospective study, 503 patients who received first-line palliative chemotherapy for mCRC between 2008 and 2014 at a tertiary hospital in Korea were evaluated...
October 18, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29044771/alkaloids-of-amaryllidaceae-as-inhibitors-of-cholinesterases-aches-and-bches-an-integrated-bioguided-study
#4
Natalie Cortes, Karina Sierra, Fernando Alzate, Edison H Osorio, Edison Osorio
INTRODUCTION: Enzymatic inhibition of acetylcholinesterase (AChE) is an essential therapeutic target for the treatment of Alzheimer's disease (AD) and AChE inhibitors are the first-line drugs for it treatment. However, butyrylcholinesterase (BChE), contributes critically to cholinergic dysfunction associated with AD. Thus, the development of novel therapeutics may involve the inhibition of both cholinesterase enzymes. OBJECTIVE: To evaluate, in an integrated bioguided study, cholinesterases alkaloidal inhibitors of Amaryllidaceae species...
October 17, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29044340/renouncement-of-renal-replacement-therapy-withdrawal-and-refusal
#5
José Andrade Moura, Ana Flávia de Souza Moura, José Hermógenes Rocco Suassuna
Renouncement of renal replacement therapy (RRT) is a medical dilemma. This review covers the concept, the magnitude, the prognosis, and discusses strategies and management approaches about this subject in patients with CKD and AKI. Evidence suggests that refusal is more frequent and carries a more guarded prognosis than withdrawal of RRT. When RRT is not expected to be beneficial in terms of survival or quality of life, conservative treatment and palliative care are alternatives. We review the historical evolution of guidelines about renouncement of RRT and palliative care, and highlight the absence of specific recommendations in Brazil...
July 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29044057/clinicodemographic-profile-and-treatment-outcome-in-patients-of-ocular-surface-squamous-neoplasia
#6
Rachna Meel, Rebika Dhiman, Murugesan Vanathi, Neelam Pushker, Radhika Tandon, Saranya Devi
PURPOSE: The aim is to study the clinicodemographic profile and treatment outcome of ocular surface squamous neoplasia (OSSN). METHODS: This was a retrospective observational study of 57 eyes (56 cases) with clinically diagnosed OSSN, presenting in our center over the past year. RESULTS: The median age of presentation was 55 years with male:female ratio being 4.5:1. Systemic predisposing conditions were xeroderma pigmentosa (1) postkidney transplant immunosuppression (1), and human immunodeficiency virus infection (1)...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29043514/efficacy-of-a-triplet-and-doublet-based-chemotherapy-as-first-line-therapy-in-patients-with-her2-negative-metastatic-gastric-cancer-a-retrospective-analysis-from-the-clinical-practice
#7
Maria Maddalena Laterza, Luca Pompella, Angelica Petrillo, Giuseppe Tirino, Annalisa Pappalardo, Michele Orditura, Teresa Troiani, Fortunato Ciardiello, Natale Di Martino, Ferdinando De Vita
The best choice of chemotherapy regimen for patients with metastatic gastric cancer is still debated. Although several studies support a superior efficacy of a triplet chemotherapy regimen over a doublet-based regimen, the magnitude of this benefit appears small and accompanied by an increased toxicity. Based on this background, we evaluated the outcome of patients with HER2-negative metastatic gastric cancer (mGC) who received in the clinical practice a triplet or doublet regimen as first-line therapy. A total of 165 patients (pts) with HER2-negative mGC treated outside of clinical trials at our department with FOLFOX-4 or ECX from 2012 and 2015 were included in our retrospective analysis: FOLFOX-4: 86 pts; ECX: 79 pts...
October 17, 2017: Medical Oncology
https://www.readbyqxmd.com/read/29043377/-lung-cancer-what-has-been-confirmed-in-therapy
#8
REVIEW
D F Heigener, M Reck
Metastatic non-small cell lung cancer has now been subdivided into several subtypes. The five basic principles of treatment include chemotherapy, anti-angiogenic therapy, targeted therapy, immunotherapy and early palliative care. The latter should be implemented for all patients with metastatic lung cancer. The use of the other modalities depends on the histological subtype, as well as on the immunohistochemical and molecular features of the tumor.
October 17, 2017: Der Internist
https://www.readbyqxmd.com/read/29042822/antipsychotic-prescription-to-identify-delirium-results-from-two-cohorts
#9
Kristin M Zimmerman, Allison M Paquin, James L Rudolph
OBJECTIVES: Detection of delirium in hospitalized patients remains challenging. The objective was to determine if the prescription of antipsychotic medications was associated with delirium. PATIENTS AND METHODS: Two patient cohorts were utilized from a tertiary Veterans Affairs hospital: a palliative care retrospective cohort and a prospective medical cohort. Patients prescribed outpatient antipsychotics were excluded. Retrospectively, delirium was identified using a validated medical record-review instrument...
2017: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/29042761/understanding-institutional-stakeholders-perspectives-on-multidrug-resistant-bacterial-organism-at-the-end-of-life-a-qualitative-study
#10
Maria Heckel, Franziska A Herbst, Thomas Adelhardt, Johanna M Tiedtke, Alexander Sturm, Stephanie Stiel, Christoph Ostgathe
BACKGROUND: Information lacks about institutional stakeholders' perspectives on management approaches of multidrug-resistant bacterial organism in end-of-life situations. The term "institutional stakeholder" includes persons in leading positions with responsibility in hospitals' multidrug-resistant bacterial organism management. They have great influence on how strategies on multidrug-resistant bacterial organism management approaches in institutions of the public health system are designed...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29042464/recognizing-the-elephant-in-the-room-palliative-care-needs-in-acute-kidney-injury
#11
EDITORIAL
Amar D Bansal, Jane O Schell
No abstract text is available yet for this article.
October 17, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29042462/infrequent-provision-of-palliative-care-to-patients-with-dialysis-requiring-aki
#12
Kelly Chong, Samuel A Silver, Jin Long, Yuanchao Zheng, V Shane Pankratz, Mark L Unruh, Glenn M Chertow
BACKGROUND AND OBJECTIVES: The use of palliative care in AKI is not well described. We sought to better understand palliative care practice patterns for hospitalized patients with AKI requiring dialysis in the United States. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using the 2012 National Inpatient Sample, we identified patients with AKI and palliative care encounters using validated International Classification of Diseases, Ninth Revision, Clinical Modification codes...
October 17, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29042354/a-comparison-between-patent-ductus-arteriosus-stent-and-modified-blalock-taussig-shunt-as-palliation-for-infants-with-ductal-dependent-pulmonary-blood-flow-insights-from-the-congenital-catheterization-research-collaborative
#13
Andrew C Glatz, Christopher J Petit, Bryan H Goldstein, Michael S Kelleman, Courtney E McCracken, Alicia McDonnell, Timothy Buckey, Christopher E Mascio, Subi Shashidharan, R Allen Ligon, Jingning Ao, Wendy Whiteside, W Jack Wallen, Christina M Metcalf, Varun Aggarwal, Hitesh Agrawal, Athar M Qureshi
Background -Infants with ductal-dependent pulmonary blood flow may undergo palliation with either a patent ductus arteriosus (PDA) stent or modified Blalock-Taussig (BT) shunt. A balanced multi-center comparison of these two approaches is lacking. Methods -Infants with ductal-dependent pulmonary blood flow, palliated with either PDA stent or BT shunt from 1/08 to 11/15, were reviewed from the four member centers of the Congenital Catheterization Research Collaborative. Outcomes were compared using propensity score adjustment to account for baseline differences between groups...
October 17, 2017: Circulation
https://www.readbyqxmd.com/read/29042266/development-and-validation-of-the-symptom-assessment-to-improve-symptom-control-for-institutionalized-elderly-scale
#14
Maaike L De Roo, Marc F Tanghe, Nele J Van Den Noortgate, Ruth D Piers
OBJECTIVES: To validate a newly developed multiple symptom self-assessment tool in nursing homes. DESIGN: Thirty prevalent symptoms identified in the literature were classified by a 2-round Delphi procedure to a top 10 of the most relevant, burdensome symptoms. Because no existing symptom scale fully covered this top 10, we developed a new scale, consisting of a horizontal numerical scale for the top 10 symptoms, with the possibility to add and rate 3 other symptoms...
October 14, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29042070/geriatric-palliative-care-meeting-the-needs-of-a-growing-population
#15
Rebecca M Saracino, Mei Bai, Leslie Blatt, Larry Solomon, Ruth McCorkle
The implementation of effective geriatric palliative care (PC) services will be increasingly important as the number of patients ages ≥65 years continues to grow. However, literature characterizing the utilization of PC services by older adults remains scant. The objective of these analyses was to characterize the nature and outcomes of PC services for older adults. A retrospective analysis of records of inpatient PC consultations provided to patients ≥65 years at an academic hospital was performed (N = 743)...
October 14, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/29041017/single-session-eus-guided-hepaticogastrostomy-and-dual-scope-gastroenterostomy-a-modified-technique-for-palliative-double-endoscopic-biliary-and-gastric-bypass
#16
Manuel Alejandro Mahler, Robin German Prieto, Inés Oria, Guido Villa-Gómez, Gustavo Vidales, Manuel Perez-Miranda
No abstract text is available yet for this article.
October 17, 2017: Endoscopy
https://www.readbyqxmd.com/read/29040995/role-of-immune-checkpoint-blockade-in-the-treatment-for-human-hepatocellular-carcinoma
#17
Naoshi Nishida, Masatoshi Kudo
With the development of molecular targeting therapy, several treatment options for advanced hepatocellular carcinoma (HCC) have become available in cases where curative and other palliative treatments, such as radiofrequency ablation, surgical resection, and transarterial chemoembolization, are not applicable. However, with the detection of a variety of mutations in cancer-related genes in a single tumor, molecular heterogeneity is commonly observed in HCC. Therefore, mutations in the major cellular signaling pathways underlie the development of resistance to molecular targeting agents...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040489/palliation-of-anastomotic-tumor-recurrence-after-esophagectomy-and-gastric-transposition-cervico-mediastinal-resection-and-reconstruction-by-using-a-free-jejunal-transplant
#18
M Hermann, H Piza-Katzer, A Leitgeb, S Roka, R Roka
No abstract text is available yet for this article.
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29040187/palliative-radiation-therapy-for-recurrent-ovarian-cancer-efficacy-and-predictors-of-clinical-response
#19
Ginger Jiang, Tracy Balboni, Allison Taylor, Joyce Liu, Larissa J Lee
OBJECTIVE: This study aimed to report response rates and predictors of response to palliative radiotherapy (RT) for recurrent ovarian cancer. METHODS/MATERIALS: Database review identified 64 patients with symptomatic ovarian cancer recurrence who received a total of 76 courses of RT for 103 indications from March 2003 to August 2014. Radiotherapy indications were pain (44%), bleeding (32%), obstruction (15%), and other (9%). Responses were categorized as complete, partial, or none; all response (AR) was the sum of complete and partial responses...
October 17, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29040110/racial-differences-in-palliative-care-use-after-stroke-in-majority-white-minority-serving-and-racially-integrated-u-s-hospitals
#20
Roland Faigle, Wendy C Ziai, Victor C Urrutia, Lisa A Cooper, Rebecca F Gottesman
OBJECTIVES: Racial/ethnic differences in palliative care resource use after stroke have been recognized, but it is unclear whether patient or hospital characteristics drive this disparity. We sought to determine whether palliative care use after intracerebral hemorrhage and ischemic stroke differs between hospitals serving varying proportions of minority patients. DESIGN: Population-based cross-sectional study. SETTING: Inpatient hospital admissions from the Nationwide Inpatient Sample between 2007 and 2011...
October 14, 2017: Critical Care Medicine
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