Christiaan H Vinkers, Ralph W Kupka, Brenda W Penninx, Henricus G Ruhé, Jakob M van Gaalen, Paul C F van Haaren, Arnt F A Schellekens, Sameer Jauhar, Josep A Ramos-Quiroga, Eduard Vieta, Jari Tiihonen, Stijn E Veldman, Wim Veling, Roeland Vis, Laura E de Wit, Jurjen J Luykx
Pharmacotherapy is an effective treatment modality across psychiatric disorders. Nevertheless, many patients discontinue their medication at some point. Evidence-based guidance for patients, clinicians, and policymakers on rational discontinuation strategies is vital to enable the best, personalized treatment for any given patient. Nonetheless, there is a scarcity of guidelines on discontinuation strategies. In this perspective, we therefore summarize and critically appraise the evidence on discontinuation of six major psychotropic medication classes: antidepressants, antipsychotics, benzodiazepines, mood stabilizers, opioids, and stimulants...
March 19, 2024: Molecular Psychiatry