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https://www.readbyqxmd.com/read/28074545/development-and-testing-of-a-database-of-nih-research-funding-of-aapm-members-a-report-from-aapm-working-group-for-the-development-of-a-research-database-wgdrd
#1
Brendan Whelan, Eduardo Moros, Rebecca Fahrig, James Deye, Thomas Yi, Michael Woodward, Paul Keall, Jeff Siewerdsen
PURPOSE: To produce and maintain a database of National Institutes of Health (NIH) funding of American Association of Physicists in Medicine (AAPM) members, to perform a top level analysis of this data, and to make this data (hereafter referred to as the AAPM research database) available for the use of the AAPM and its members. METHODS: NIH funded research dating back to 1985 is available for public download through the NIH exporter website, and AAPM membership information dating back to 2002 was supplied by the AAPM...
January 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28061980/mind-the-gap-an-analysis-of-foregone-health-gains-from-unfunded-cancer-medicines-in-new-zealand
#2
REVIEW
Jackie Evans, George Laking, Matthew Strother, Tony Wang, Scott Metcalfe, Gary Blick, Reinhard Pauls, Steffan Crausaz
Publicly funded cancer medicines listed on the New Zealand Pharmaceutical Schedule were compared with those listed on the Australian Pharmaceutical Benefits Scheme. To quantify the health gains offered by the cancer medicines funded in Australia but not in New Zealand, clinical trial data reporting median progression-free survival (PFS) and overall survival (OS) were sought. The differences in the median PFS and OS for the unfunded medicines, relative to the comparator medicine funded in NZ, were then assessed against the American Society of Clinical Oncology Cancer Research Committee (ASCO-CRC) recommended targets for clinically meaningful health gains...
December 2016: Seminars in Oncology
https://www.readbyqxmd.com/read/28060965/the-clinical-research-landscape-in-rhode-island
#3
George Mao, Bharat Ramratnam
OBJECTIVES: To present an overview of clinical research activity and the state of medical research funding in Rhode Island. METHODS: We utilized clinicaltrials.gov registry to profile clinical studies between 2011 to 2016. NIH RePORT and other federal databases were used to extract information on levels of federal funding. Previously published hospital financial reports were reviewed for data on hospital-specific total external research funding. RESULTS: During 2011-2016, 1651 clinical studies were registered in clinicaltrials...
January 6, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28057355/physical-activity-and-breast-cancer-risk-by-pathological-subtype
#4
Virginia Lope, Miguel Martín, Adela Castelló, Soraya Casla, Amparo Ruiz, Jose Manuel Baena-Cañada, Ana Mª Casas, Lourdes Calvo, Begoña Bermejo, Montserrat Muñoz, Manuel Ramos, Ana de Juan-Ferré, Carlos Jara, Antonio Antón, Mª Ángeles Jimeno, Ana Lluch, Silvia Antolín, José Ángel García-Sáenz, Purificación Estévez, Esperanza Arriola-Arellano, Joaquín Gavilá, Beatriz Pérez-Gómez, Eva Carrasco, Marina Pollán
OBJECTIVE: To examine the influence of physical activity on breast cancer risk and evaluate whether adherence to international recommendations is associated with a decreased risk. METHODS: This is a multicenter matched case-control study where 698 pairs completed a physical activity questionnaire. Recreational physical activity during the last year was quantified in metabolic equivalent hours per week (MET-h/week) and categorized in activities of moderate (3.0-5...
January 2, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28055251/commentary-opportunities-for-research-in-molecular-radiotherapy
#5
Glenn D Flux, Joe O'Sullivan, Mark N Gaze, Kevin M Prise
Cancer has been treated with radiopharmaceuticals for 80 years. A recent NCRI report from the Clinical and Translational Radiotherapy Research Working Group (CTRad) reviews the current status of molecular radiotherapy (MRT) and has highlighted the barriers to, and the opportunities for increased research activities. The report recommends a number of actions to promote this field, which in the dawning age of personalised medicine and theragnostics is of increasing importance, particularly with the clinical introduction of a range of new commercial radiotherapeutics at costs in line with those seen for conventional chemotherapeutics...
January 5, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28048932/th-b-204-03-tg-199-implanted-markers-for-radiation-treatment-verification
#6
Z Wang
: Implanted markers as target surrogates have been widely used for treatment verification, as they provide safe and reliable monitoring of the inter- and intra-fractional target motion. The rapid advancement of technology requires a critical review and recommendation for the usage of implanted surrogates in current field. The symposium, also reporting an update of AAPM TG 199 - Implanted Target Surrogates for Radiation Treatment Verification, will be focusing on all clinical aspects of using the implanted target surrogates for treatment verification and related issues...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048906/su-f-t-666-molecular-targeted-gold-nanorods-enhances-the-rbe-of-proton-therapy
#7
A Khoo, N Sahoo, S Krishnan, P Diagaradjane
PURPOSE: In recent years, proton beam radiation therapy (PBRT) has gained significant attention in the treatment of tumors in anatomically complex locations. However, the therapeutic benefit of PBRT is limited by a relative biological effectiveness (RBE) of just 1.1. The purpose of this study is to evaluate whether this limitation can be overcome by artificially enhancing the RBE using molecular-targeted gold nanorods (GNRs). METHODS: Molecular-targeting of GNRs was accomplished using Cetuximab (antibody specific to epidermal growth factor receptor that is over-expressed in tumors) conjugated GNRs (cGNRs) and their binding affinity to Head and Neck cancer cells was confirmed using dark field microscopy and Transmission Electron Microscopy (TEM)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048834/th-ef-bra-03-assessment-of-data-driven-respiratory-motion-compensation-methods-for-4d-cbct-image-registration-and-reconstruction-using-clinical-datasets
#8
M J Riblett, E Weiss, G E Christensen, G D Hugo
PURPOSE: To evaluate the performance of a 4D-CBCT registration and reconstruction method that corrects for respiratory motion and enhances image quality under clinically relevant conditions. METHODS: Building on previous work, which tested feasibility of a motion-compensation workflow using image datasets superior to clinical acquisitions, this study assesses workflow performance under clinical conditions in terms of image quality improvement. Evaluated workflows utilized a combination of groupwise deformable image registration (DIR) and image reconstruction...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048821/mo-g-201-02-comparing-sample-size-requirements-for-knowledge-based-treatment-planning
#9
J J Boutilier, A D C Babier, T Craig, A L McNiven, M B Sharpe, T C Y Chan
PURPOSE: To compare how training set size affects the accuracy of a knowledge-based planning (KBP) model applied to prostate and head and neck (HN) cancer. METHODS: We selected a KBP model from the literature that uses distance-to-target histograms and organ volumes to predict an achievable dose-volume-histogram (DVH) curve for each organ-at-risk (OAR). We trained both the prostate and HN model using training set sizes of n=10, 20, 30, 50,75, and 100. We set aside 100 randomly selected treatment plans from each of the two respective cohorts of 218 to serve as a validation set for all experiments...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048772/mo-de-207a-04-development-and-evaluation-of-an-adaptive-deformation-recovery-and-intensity-correction-adric-ct-reconstruction-technique
#10
Y Zhang, J Ma, J Wang
PURPOSE: Sequential same-patient CT images usually involve deformation-induced and non-deformation-induced voxel intensity changes. An adaptive deformation-recovery and intensity-correction (ADRIC) technique was developed to improve the CT reconstruction accuracy, and to separate deformation from non-deformation-induced voxel intensity changes between sequential CT images. METHODS: ADRIC views the new CT as a deformation of a prior high-quality CT volume, but with additional non-deformation-induced voxel intensity changes...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048764/tu-d-202-00-rest-in-peace-itv
#11
Marcel van Herk
: Respiratory motion has long been recognized as an important factor affecting the precision of radiotherapy. After the introduction of the 4D CT to visualize the respiratory motion in 3D, the internal target volume (ITV) has been widely adopted as simple method to take the motion into account in treatment planning and delivery. The ITV is generated as the union of the CTVs as the patient goes through the respiratory cycle. Many issues have been identified with the ITV. In this session three alternatives for the ITV will be discussed: 1) An alternative motion-inclusive approach with better imaging and smaller margins, called mid-position CT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048706/tu-ab-bra-06-best-in-physics-joint-imaging-therapy-an-mri-compatible-externally-and-internally-deformable-lung-motion-phantom-for-multi-modality-igrt
#12
P Sabouri, T Arai, A Sawant
PURPOSE: MRI has become an attractive tool for tumor motion management. Current MR-compatible phantoms are only capable of reproducing translational motion. This study describes the construction and validation of a more realistic, MRI-compatible lung phantom that is deformable internally as well as externally. We demonstrate a radiotherapy application of this phantom by validating the geometric accuracy of the open-source deformable image registration software NiftyReg (UCL, UK). METHODS: The outer shell of a commercially-available dynamic breathing torso phantom was filled with natural latex foam with eleven water tubes...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048692/mo-fg-207b-01-thorax-lung
#13
H Aerts
State-of-the-Art in Radiomics in Radiology and Radiation Oncology Radiomics is the science of converting medical images into mineable data, data that are descriptive of "phenotypes," which may provide diagnostic, prognostic, or therapeutic information. Genomics is the science of sequencing and analyzing the function and structure of genomes; the complete set of DNA in a single cell of an organism. In turn, imaging genomics (or radiogenomics) is concerned with the correlation between image-based features, as determined by radiomics, and gene expression, as determined by genomics...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048687/tu-fg-207b-05-funding-opportunities-at-the-national-science-foundation
#14
W Olbricht
: Up-to-date knowledge about federal funding opportunities related to medical physics research, as well as obtaining skills for writing effective grant proposals are critical for academic and entrepreneurial medical physicists. In this symposium, program directors from key federal research funding agencies, including the National Cancer Institute, the National Institute of Biomedical Imaging and Bioengineering, and the National Science Foundation, will present information about current funding opportunities relevant to the field of medical physics...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048670/tu-fg-brc-01-cancer-and-the-immune-system-the-basics
#15
E Repasky
: There is substantial current interest in the potential of radiation therapy for synergizing with novel immunotherapies to transform irradiated tumor into an immunogenic hub with capacity to ignite a powerful and adaptive longterm anti-cancer response. Interest stems from new insights into fundamental mechanisms underlying interactions between cancer, radiation and the immune system. Radically new immunotherapy approaches have been proposed, which target the immune system, rather than the cancer itself...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048664/tu-d-202-03-gating-is-the-best-itv-killer
#16
D Low
: Respiratory motion has long been recognized as an important factor affecting the precision of radiotherapy. After the introduction of the 4D CT to visualize the respiratory motion in 3D, the internal target volume (ITV) has been widely adopted as simple method to take the motion into account in treatment planning and delivery. The ITV is generated as the union of the CTVs as the patient goes through the respiratory cycle. Many issues have been identified with the ITV. In this session three alternatives for the ITV will be discussed: 1) An alternative motion-inclusive approach with better imaging and smaller margins, called mid-position CT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048641/tu-fg-207b-01-report-on-development-of-a-database-of-nih-funding-of-medical-physicists
#17
B Whelan
: Up-to-date knowledge about federal funding opportunities related to medical physics research, as well as obtaining skills for writing effective grant proposals are critical for academic and entrepreneurial medical physicists. In this symposium, program directors from key federal research funding agencies, including the National Cancer Institute, the National Institute of Biomedical Imaging and Bioengineering, and the National Science Foundation, will present information about current funding opportunities relevant to the field of medical physics...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048634/tu-h-brb-01-physics-and-dosimetry-for-radiation-countermeasure-research
#18
J Bourland
: The US government has substantial research and development activities underway for medical countermeasures that will insure the long-term safety and survival of the country's population after unfortunate large-scale biological, chemical and radiological and nuclear events. Preparedness includes research and development of medical countermeasures to address radiation-induced cutaneous and internal injury from radiation and nuclear events as well as for minimizing radiation risks incurred during and after travel in space...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048633/tu-ab-202-08-generating-organ-surfaces-to-overcome-random-contouring-errors-and-slice-thickness-variations-on-multimodality-images
#19
S Oh, E Weiss, G Christensen, G Hugo, J Williamson
PURPOSE: To propose a new method that generates smooth organ surface meshes that overcomes random contouring errors and volume averaging artifacts for hollow organs. METHODS: The proposed contour-to-smooth mesh generation method (CSMG) consists of two parts; 1) reconstructing the inner and outer surfaces of the hollow organ with triangular meshes based on parametric active surface (PAS) and 2) modifying the reconstructed inner surface in order to satisfy minimum wall thickness constraints and matching the patient's known organ wall volume...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048615/tu-h-202-04-the-vampire-challenge-preliminary-results-from-a-multi-institutional-study-of-ct-ventilation-image-accuracy
#20
J Kipritidis
: CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
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