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Cancer research funding

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https://www.readbyqxmd.com/read/28911214/growth-regulation-by-estrogen-in-breast-cancer-1-greb1-is-a-novel-progesterone-responsive-gene-required-for-human-endometrial-stromal-decidualization
#1
Alison J Camden, Maria M Szwarc, Sangappa B Chadchan, Francesco J DeMayo, Bert W O'Malley, John P Lydon, Ramakrishna Kommagani
STUDY QUESTION: Is Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) required for progesterone-driven endometrial stromal cell decidualization? SUMMARY ANSWER: GREB1 is a novel progesterone-responsive gene required for progesterone-driven human endometrial stromal cell (HESC) decidualization. WHAT IS KNOWN ALREADY: Successful establishment of pregnancy requires HESCs to transform from fibroblastic to epithelioid cells in a process called decidualization...
September 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28911065/development-of-an-integrated-electronic-platform-for-patient-self-report-and-management-of-adverse-events-during-cancer-treatment
#2
P Holch, L Warrington, L C A Bamforth, A Keding, L E Ziegler, K Absolom, C Hector, C Harley, O Johnson, G Hall, C Morris, G Velikova
Background: Significant adverse events (AE) during cancer therapy disrupt treatment and escalate to emergency admissions. Approaches to improve the timeliness and accuracy of AE reporting may improve safety and reduce health service costs. Reporting AE via patient reported outcomes (PROs), can improve clinician-patient communication and making data available to clinicians in 'real-time' using electronic PROs (ePROs) could potentially transform clinical practice by providing easily accessible records to guide treatment decisions...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28893332/legitimacy-of-medicines-funding-in-the-era-of-accelerated-access
#3
Jessica Pace, Sallie-Anne Pearson, Wendy Lipworth
OBJECTIVES: In recent years, numerous frameworks have been developed to enhance the legitimacy of health technology assessment processes. Despite efforts to implement these "legitimacy frameworks," medicines funding decisions can still be perceived as lacking in legitimacy. We, therefore, sought to examine stakeholder views on factors that they think should be considered when making decisions about the funding of high-cost breast cancer therapies, focusing on those that are not included in current frameworks and processes...
September 12, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28892777/adherence-to-the-world-cancer-research-fund-american-institute-for-cancer-research-recommendations-and-colorectal-cancer-risk
#4
Federica Turati, Francesca Bravi, Matteo Di Maso, Cristina Bosetti, Jerry Polesel, Diego Serraino, Michela Dalmartello, Attilio Giacosa, Maurizio Montella, Alessandra Tavani, Eva Negri, Carlo La Vecchia
BACKGROUND: The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) released in 2007 eight recommendations for cancer prevention on body fatness, diet and physical activity. Our aim is to evaluate the relation between adherence to these recommendations and colorectal cancer (CRC) risk. METHODS: We pooled data from two Italian case-control studies including overall 2419 patients with CRC and 4723 controls. Adherence to the WCRF/AICR guidelines was summarised through a score incorporating seven of the WCRF/AICR recommendations, with higher scores indicating higher adherence to the guidelines...
September 8, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28876649/an-evaluation-of-epidemiological-differences-in-colorectal-cancer-patients-over-and-under-the-age-of-50-presenting-to-academic-centers-in-johannesburg
#5
B D Bebington
BACKGROUND: As in other developing countries, the nations of Sub-Saharan Africa have seen an increase in the incidence of colorectal cancer. Repeatedly, the indigenous populations have shown a skewing of incidence in favour of patients below the age of 50. As part of a larger study, and through funding from the Medical research Council of South Africa, the Wits MRC Oncology group has set out to identify the epidemiological characteristics and disease progression of patients under the age of 50 presenting with colorectal cancer...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28870120/virotherapy-research-in-germany-from-engineering-to-translation-a-review-as-contribution-to-the-combined-annual-meeting-of-the-german-and-european-societies-of-gene-and-cell-therapy-2017
#6
Guy Ungerechts, Christine E Engeland, Christian J Buchholz, Jürgen Eberle, Henry Fechner, Karsten Geletneky, Per Sonne Holm, Florian Kreppel, Florian Kühnel, Karl Sebastian Lang, Mathias F Leber, Antonio Marchini, Markus Moehler, Michael D Mühlebach, Jean Rommelaere, Christoph Springfeld, Ulrich M Lauer, Dirk M Nettelbeck
Virotherapy is a unique modality for treatment of cancer with oncolytic viruses (OVs) that selectively infect and lyse tumor cells, spread within tumors, and activate anti-tumor immunity. Different viruses are being developed as OVs preclinically and clinically, several of them engineered to encode therapeutic proteins for tumor-targeted gene therapy. Scientists and clinicians in Germany have made significant contributions to OV research and development, which are highlighted in this review article. Innovative strategies for "shielding", entry- or post-entry targeting, and "arming" of OVs have been established focusing on adeno-, measles, parvo-, and vaccinia virus platforms...
September 4, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28865970/-description-of-the-gortec-2017-03-study-postoperative-stereotactic-radiotherapy-for-early-stage-oropharyngeal-and-oral-cavity-cancer-with-high-risk-margin-phrc-k-16-164
#7
J Biau, J Miroir, C Millardet, N Saroul, N Pham-Dang, S Racadot, F Huguet, F Kwiatkowski, B Pereira, J Bourhis, M Lapeyre
The GORTEC 2017-03-Stereo-postop study is a phase 2, multicentric, nationwide study, funded by the hospital clinical research program (PHRC). The sponsor is Centre Jean-Perrin in Clermont-Ferrand, in partnership with the GORTEC. The principal investigators are Dr J Biau and Dr M Lapeyre. The main objective is to study severe late toxicity of postoperative stereotactic radiotherapy (6×6Gy) for early stage oropharyngeal and oral cavity cancer with high risk margins. The secondary objectives include acute toxicity, efficacy, nutritional impact and quality of life...
August 30, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28864548/cell-scientist-to-watch-ana-garcia-saez
#8
(no author information available yet)
Ana Garcia-Saez graduated with a master's degree in biochemistry from the University of Valencia, Spain, before completing a PhD in the laboratory of Jesus Salgado in 2005. Afterwards Ana joined the research group of Petra Schwille at the Dresden University of Technology, Germany. In 2010, she started her own group at BioQuant, the Center for Quantitative Analysis of Molecular and Cellular Biosystems, at Heidelberg University with funding from the Max Planck Institute for Intelligent Systems and the German Cancer Research Centre (DKFZ)...
September 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28863804/investigation-of-a-gene-signature-to-predict-response-to-immunomodulatory-derivatives-for-patients-with-multiple-myeloma-an-exploratory-retrospective-study-using-microarray-datasets-from-prospective-clinical-trials
#9
Manisha Bhutani, Qing Zhang, Reed Friend, Peter M Voorhees, Lawrence J Druhan, Bart Barlogie, Pieter Sonneveld, Gareth J Morgan, James T Symanowski, Belinda R Avalos, Edward A Copelan, Saad Z Usmani
BACKGROUND: Immunomodulatory derivatives (IMiDs), along with proteasome inhibitors, are key components of treatment regimens for multiple myeloma. Nonetheless, outcomes vary among treated individuals. Drug-specific gene-expression profile (GEP) signatures that aid the prediction of favourable and unfavourable outcomes can provide patients with the most effective therapy for their individual disease. We aimed to develop and validate a gene expression signature to suggest which patients would benefit most from IMiD-based therapies...
September 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28861656/an-opportune-and-unique-research-to-evaluate-the-public-health-impact-of-electronic-cigarettes
#10
Ahmad Besaratinia, Stella Tommasi
In response to the growing public health concern regarding the risks or benefits of electronic cigarettes (e-cig) use relative to smoking, the National Institute on Drug Abuse (NIDA) has recently introduced the first standardized- and well- characterized e-cig device to the research community (see, https://www.drugabuse.gov/funding/supplemental-information-nida-e-cig ). E-cig are promoted as safe alternatives to conventional tobacco cigarettes and/or as aides to smoking cessation. E-cig are highly popular among cigarette smokers who are unable/unwilling to quit but are willing to switch to putatively less-harmful tobacco substitutes...
August 31, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28836478/the-clinical-research-associate-retention-study-a-report-from-the-children-s-oncology-group
#11
Emily E Owens Pickle, Dawn Borgerson, Anelise Espirito-Santo, Sabrina Wigginton, Susan Devine, Sue Stork
Pediatric medicine often struggles to receive adequate research funding for its small, yet vulnerable population of patients. Remarkable discovery in pediatric oncology is credited in large part to the collaborative structure of its research community. The Children's Oncology Group conducts studies supported by the National Cancer Institute. The clinical research associate (CRA) discipline comprises professionals who support administrative duties, regulatory duties, subject management, and data collection at individual research sites...
August 1, 2017: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/28818252/origins-of-cancer-disparities-in-young-adults-logic-models-to-guide-research
#12
Robert A Hiatt, Margaret A Handley, Pamela M Ling, Esteban Burchard, Neeta Thakur, Kirsten Bibbins-Domingo
Cancer disparities research is motivated by persistent inequities in cancer outcomes by race, ethnicity, social status, neighborhood location, and other subpopulation characteristics. These inequities have proven to be persistent and difficult to alter. Part of the reason for the frustration with slow progress is a lack of appreciation of the long-term nature of the undertaking. It is highly likely that the disparities observed in adulthood find their origins in young adulthood, if not earlier. A long-term perspective is needed, recognizing that successes may take many years to realize...
September 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28797846/african-medicinal-plants-and-their-derivatives-current-efforts-towards-potential-anti-cancer-drugs
#13
REVIEW
Mzwandile Mbele, Rodney Hull, Zodwa Dlamini
Cancer is a leading cause of mortality and morbidity worldwide and second only to cardiovascular diseases. Cancer is a challenge in African countries because generally there is limited funding available to deal with the cancer epidemic and awareness and this should be prioritised and all possible resources should be utilized to prevent and treat cancer. The current review reports on the role of African medicinal plants in the treatment of cancer, and also outlines methodologies that can also be used to achieve better outcomes for cancer treatment...
August 8, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28792880/analysis-of-plasma-epstein-barr-virus-dna-to-screen-for-nasopharyngeal-cancer
#14
COMPARATIVE STUDY
K C Allen Chan, John K S Woo, Ann King, Benny C Y Zee, W K Jacky Lam, Stephen L Chan, Sam W I Chu, Constance Mak, Irene O L Tse, Samantha Y M Leung, Gloria Chan, Edwin P Hui, Brigette B Y Ma, Rossa W K Chiu, Sing-Fai Leung, Andrew C van Hasselt, Anthony T C Chan, Y M Dennis Lo
BACKGROUND: Circulating cell-free Epstein-Barr virus (EBV) DNA is a biomarker for nasopharyngeal carcinoma. We conducted a prospective study to investigate whether EBV DNA in plasma samples would be useful to screen for early nasopharyngeal carcinoma in asymptomatic persons. METHODS: We analyzed EBV DNA in plasma specimens to screen participants who did not have symptoms of nasopharyngeal carcinoma. Participants with initially positive results were retested approximately 4 weeks later, and those with persistently positive EBV DNA in plasma underwent nasal endoscopic examination and magnetic resonance imaging (MRI)...
August 10, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28781171/first-line-selective-internal-radiotherapy-plus-chemotherapy-versus-chemotherapy-alone-in-patients-with-liver-metastases-from-colorectal-cancer-foxfire-sirflox-and-foxfire-global-a-combined-analysis-of-three-multicentre-randomised-phase-3-trials
#15
Harpreet S Wasan, Peter Gibbs, Navesh K Sharma, Julien Taieb, Volker Heinemann, Jens Ricke, Marc Peeters, Michael Findlay, Andrew Weaver, Jamie Mills, Charles Wilson, Richard Adams, Anne Francis, Joanna Moschandreas, Pradeep S Virdee, Peter Dutton, Sharon Love, Val Gebski, Alastair Gray, Guy van Hazel, Ricky A Sharma
BACKGROUND: Data suggest selective internal radiotherapy (SIRT) in third-line or subsequent therapy for metastatic colorectal cancer has clinical benefit in patients with colorectal liver metastases with liver-dominant disease after chemotherapy. The FOXFIRE, SIRFLOX, and FOXFIRE-Global randomised studies evaluated the efficacy of combining first-line chemotherapy with SIRT using yttrium-90 resin microspheres in patients with metastatic colorectal cancer with liver metastases. The studies were designed for combined analysis of overall survival...
August 3, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28780541/associations-between-highly-active-antiretroviral-therapy-and-the-presence-of-hpv-premalignant-and-malignant-cervical-lesions-in-sub-saharan-africa-a-systematic-review-current-evidence-and-directions-for-future-research
#16
Sonia Menon, Rodolfo Rossi, Natasha Zdraveska, Mbabazi Kariisa, Sushama D Acharya, Davy Vanden Broeck, Steven Callens
OBJECTIVES: In sub-Saharan Africa, substantial international funding along with evidence-based clinical practice have resulted in an unparalleled scale-up of access to antiretroviral treatment at a higher CD4 count. The role and timing of highly active antiretroviral therapy (HAART) in mediating cervical disease remains unclear. The aim of this article is to systematically review all evidence pertaining to Africa and identify research gaps regarding the epidemiological association between HAART use and the presence of premalignant/malignant cervical lesions...
August 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28780132/commentary-on-comprehensive-molecular-characterization-of-papillary-renal-cell-carcinoma-cancer-genome-atlas-research-network-n-engl-j-med-2016-jan-14-374-2-135-45
#17
Byron H Lee
BACKGROUND: Papillary renal-cell carcinoma, which accounts for 15%-20% of renal-cell carcinomas, is a heterogeneous disease that consists of various types of renal cancer, including tumors with indolent, multifocal presentation, and solitary tumors with an aggressive, highly lethal phenotype. Little is known about the genetic basis of sporadic papillary renal-cell carcinoma, and no effective forms of therapy for advanced disease exist. METHODS: We performed comprehensive molecular characterization of 161 primary papillary renal-cell carcinomas, using whole-exome sequencing, copy-number analysis, messenger RNA and microRNA sequencing, DNA-methylation analysis, and proteomic analysis...
August 2, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28774559/implementation-of-hpv-vaccination-guidelines-in-a-diverse-population-in-los-angeles-results-from-an-environmental-scan-of-local-hpv-resources-and-needs
#18
Lourdes Baezconde-Garbanati, Brianna A Lienemann, Marisela Robles, Ethel Johnson, Kathleen Sanchez, Rita Singhal, Jane Steinberg, Jenny M Jaque, Mary Ann Pentz, Stephen Gruber
Research shows that vaccination against human papillomavirus (HPV) infection is one of the most effective methods for reducing risk for cervical cancer; it also protects against other HPV-related cancers. Controversies exist regarding HPV vaccination in several communities; which may in part explain why although rates of HPV vaccination are increasing nationwide, Los Angeles County (LAC) data show that many adolescents are still not vaccinated. These adolescents remain at high-risk for infection. Using community-based participatory principles, we conducted an environmental scan that included a literature review, the development of a community advisory board, community feedback from HPV community meetings, and interviews with stakeholders to understand attitudes toward HPV vaccination and their impact in follow through with HPV vaccines...
September 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28762038/considerations-in-t-cell-therapy-product-development-for-b-cell-leukemia-and-lymphoma-immunotherapy
#19
REVIEW
Andrew D Fesnak, Patrick J Hanley, Bruce L Levine
Based on laboratory and clinical research findings and investments in immunotherapy by many institutions in academia, government-funded laboratories, and industry, there is tremendous and deserved excitement in the field of cell and gene therapy. In particular, understanding of immune-mediated control of cancer has created opportunities to develop new forms of therapies based on engineered T cells. Unlike conventional drugs or biologics, the source material for these new therapies is collected from the patient or donor...
July 31, 2017: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/28759387/the-role-of-government-and-regulation-in-cancer-prevention
#20
REVIEW
Otis W Brawley
The world population is ageing and increasing in size. As a result, the numbers of people diagnosed with and dying of cancer are increasing. Cancer is also a growing problem in developing countries. Government, be it local, state, provincial, national, or even a union of nations, has clear roles in the control of cancer. It is widely appreciated that much of the research that has defined the causes and treatment of cancer was, and is, government funded. Less appreciated, the body of work about how to control cancer shows the importance of an environment that encourages individuals to adopt healthy behaviours, and government has a vitally important role...
August 2017: Lancet Oncology
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