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Five year survival rate

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https://www.readbyqxmd.com/read/28100318/-clinical-characteristics-of-clonal-evolution-after-immunosuppressive-therapy-in-children-with-severe-very-severe-aplastic-anemia
#1
Jing-Liao Zhang, Tian-Feng Liu, Li-Xian Chang, Xia Chen, Yuan-Yuan Ren, Cong-Cong Sun, Chao Liu, Wen-Bin An, Yang Wan, Xiao-Juan Chen, Wen-Yu Yang, Shu-Chun Wang, Ye Guo, Yao Zou, Yu-Mei Chen, Xiao-Fan Zhu
OBJECTIVE: To evaluate the clinical characteristics and risk factors of clonal evolution after immunosuppressive therapy (IST) in children with severe/very severe aplastic anemia (SAA/VSAA). METHODS: The clinical data of 231 children with newly-diagnosed SAA/VSAA who received IST were retrospectively studied. The incidence and risk factors of clonal evolution after IST were analyzed. RESULTS: The 5-year overall survival rate of the 231 patients was 82...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28100214/preoperative-lipiodol-marking-and-its-role-on-survival-and-complication-rates-of-ct-guided-cryoablation-for-small-renal-masses
#2
Fumiya Hongo, Yasuhiro Yamada, Takashi Ueda, Terukazu Nakmura, Yoshio Naya, Kazumi Kamoi, Koji Okihara, Yusuke Ichijo, Tsuneharu Miki, Kei Yamada, Osamu Ukimura
BACKGROUND: Partial nephrectomy for small renal masses (SRM) may be useful for preserving renal function, but is technically more difficult than radical nephrectomy. Cryoablation may be performed under local anesthesia. The objective of the present study is to assess the safety and therapeutic efficacy of cryoablation with lipiodol marking for SRM. METHODS: Cryoablation therapy was performed on 42 patients under local anesthesia. Their median age was 74 years (31-91)...
January 18, 2017: BMC Urology
https://www.readbyqxmd.com/read/28099450/advanced-neonatal-medicine-in-china-a-national-baseline-database
#3
Xiang-Peng Liao, Selma Chipenda-Dansokho, Antoine Lewin, Nadia Abdelouahab, Shu-Qin Wei
Previous surveys of neonatal medicine in China have not collected comprehensive information on workforce, investment, health care practice, and disease expenditure. The goal of the present study was to develop a national database of neonatal care units and compare present outcomes data in conjunction with health care practices and costs. We summarized the above components by extracting data from the databases of the national key clinical subspecialty proposals issued by national health authority in China, as well as publicly accessible databases...
2017: PloS One
https://www.readbyqxmd.com/read/28099405/insights-in-transplanting-complex-paediatric-renal-recipients-with-vascular-anomalies
#4
Pankaj Chandak, Nicos Kessaris, Chris J Callaghan, Francis Calder, Jelena Stojanovic, Jonathon Olsburgh, Martin Drage, Helen Hume-Smith, Zubir Ahmed, Anna Adamusiak, Derek Roebuck, Colin Forman, Stephen D Marks, Nizam Mamode
BACKGROUND: Children with end-stage kidney disease may have co-existing iatrogenic or congenital vascular anomalies making transplantation difficult. We describe our approach in 5 recipients with vascular anomalies and significant co-morbidities, including one case of blood group incompatibility. METHODS: Five children aged 3 - 17 (median 7) years, weighing 14 - 34 (median 18) kg of whom 4 had occluded inferior vena cava or iliac veins and 2 had previous complex vascular reconstructions prior to transplantation for mid-aortic syndrome and multiple aortic aneurysms, respectively underwent renal transplantation...
January 17, 2017: Transplantation
https://www.readbyqxmd.com/read/28099173/surgical-approach-for-ulcerated-locally-advanced-breast-cancer-a-single-center-experience-a-retrospective-study
#5
Rita Laforgia, Clelia Punzo, Annunziata Panebianco, Annalisa Volpi, Marina Minafra, Maria Grazia Sederino
AIM: The aim of our retrospective study is to analyze surgical possibilities for the extended LABC in those cases not suitable for a neoadjuvant chemotherapy step and to consider various reconstruction techniques. MATERIAL OF STUDY: Between 2009 and 2015 we enrolled 11 patients, admitted to the Emergency Department, presenting ulcerated LABC that needed palliative surgical demolitive procedures because of bleeding and anemia and in which was necessary to use natural tissues transposition or synthetic substitutes for the reconstruction of the skin flaps...
January 12, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28097314/complications-of-bilateral-neck-dissection-in-thyroid-cancer-from-a-single-high-volume-center
#6
Caitlin McMullen, Daniel Rocke, Jeremy Freeman
Importance: The morbidity of bilateral lateral neck dissection (BLND) for thyroid cancers has not been described in detail. This study delineates the specific complications arising from BLND for thyroid cancers at a single high-volume center. Objective: To determine the morbidity associated with BLNDs for differentiated thyroid cancers at our institution. Design, Setting, and Participants: This was a retrospective review of medical records performed to identify patients having undergone BLNDs for thyroid cancers by a single surgeon at an academic, tertiary medical center in Toronto, Ontario, Canada, from 1988 to 2015...
January 12, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28097193/axillary-versus-femoral-arterial-cannulation-during-repair-of-type-a-aortic-dissection-an-old-problem-seeking-new-solutions
#7
Sotiris C Stamou, Derek Gartner, Nicholas T Kouchoukos, Kevin W Lobdell, Kamal Khabbaz, Edward Murphy, Robert C Hagberg
BACKGROUND: The goal of this study was to compare early postoperative outcomes and actuarial-free survival between patients who underwent repair of acute Type A aortic dissection with axillary or femoral artery cannulation. METHODS: A total of 305 patients from five academic medical centers underwent acute Type A aortic dissection repair via axillary (n = 107) or femoral (n = 198) artery cannulation between January 2000 and December 2010. Major morbidity, operative mortality, and 5-year actuarial survival were compared between groups...
August 2016: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/28096199/trends-in-radiation-therapy-among-cancer-survivors-in-the-united-states-2000-2030
#8
Alex K Bryant, Matthew Banegas, Maria E Martinez, Loren K Mell, James D Murphy
BACKGROUND: Although the number of cancer survivors has increased substantially over the past several decades, the composition of survivors treated with radiotherapy is not well defined. Radiotherapy carries unique long-term toxicity risks for cancer survivors. This study describes the current estimates and future projections of the epidemiology of five-year cancer survivors who receive radiation therapy. METHODS: We used cancer incidence and survival data from the Surveillance, Epidemiology, and End-Results (SEER) database linked to US Census data to estimate the number of five-year cancer survivors treated with radiation between 2000 and 2030...
January 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28096057/the-five-year-survival-rate-after-endoscopic-submucosal-dissection-for-superficial-esophageal-squamous-cell-neoplasia
#9
Yasuaki Nagami, Masaki Ominami, Masatsugu Shiba, Hiroaki Minamino, Shusei Fukunaga, Natsuhiko Kameda, Satoshi Sugimori, Hirohisa Machida, Tetsuya Tanigawa, Hirokazu Yamagami, Toshio Watanabe, Kazunari Tominaga, Yasuhiro Fujiwara, Tetsuo Arakawa
BACKGROUND: Endoscopic submucosal dissection (ESD) is a widely accepted procedure for superficial esophageal squamous cell neoplasia (ESCN) because of a high complete resection rate. However, there were a few reports about the long-term outcomes of these patients due to short follow-up periods. AIMS: We aimed to evaluate the 5-year survival after ESD for superficial ESCN. METHODS: This was a retrospective cohort study performed at a single institution...
December 21, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28095994/outcome-of-early-stage-cervical-cancer-patients-treated-according-to-a-radiosurgical-approach-clinical-results-and-prognostic-factors
#10
Escande Alexandre, Gouy Sebastien, Mazeron Renaud, Bentivegna Enrica, Bacorro Warren, Maroun Pierre, Schernberg Antoine, Oberlander Anne-Sophie, Dumas Isabelle, Genestie Catherine, Deutsch Eric, Morice Philippe, Haie-Meder Christine, Chargari Cyrus
OBJECTIVE: To report clinical results of a multimodal strategy based on preoperative brachytherapy followed with surgery in early stage cervical cancer. MATERIALS/METHODS: The outcome of consecutive patients receiving brachytherapy in our Institution for an early stage IB1-IIA1 invasive cervical cancer with risk factors (lymphovascular embols and/or tumor >2cm) between 2000 and 2013 was analyzed. The treatment consisted of preoperative low dose or pulse dose-rate utero-vaginal brachytherapy followed, 6-8weeks later, by a radical hysterectomy/bilateral salpingo-oophorectomy plus pelvic±para-aortic lymph node dissection...
January 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28095599/minerals-in-the-foods-and-diet-of-diademed-sifakas-are-they-nutritional-challenges
#11
Mitchell T Irwin, Jean-Luc Raharison, Colin A Chapman, Randall E Junge, Jessica M Rothman
: Minerals, though needed in small quantities, are essential to metabolic processes, and deficiencies can seriously threaten health, reproduction and survival. Despite this, few studies have measured mineral composition of wild primate foods and fewer have quantified mineral intake. Here we measured the concentration of nine minerals in 75 foods of diademed sifakas (Propithecus diadema; five groups) in habitats with varying levels of disturbance at Tsinjoarivo and estimated daily intakes using focal-animal feeding data and intake rates over one year...
January 17, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28095396/tenascin-c-and-fibronectin-expression-divide-early-stage-tongue-cancer-into-low-and-high-risk-groups
#12
Elias Sundquist, Joonas H Kauppila, Johanna Veijola, Rayan Mroueh, Petri Lehenkari, Saara Laitinen, Juha Risteli, Ylermi Soini, Veli-Matti Kosma, Iris Sawazaki-Calone, Carolina Carneiro Soares Macedo, Risto Bloigu, Ricardo D Coletta, Tuula Salo
BACKGROUND: Oral tongue squamous cell carcinoma (OTSCC) metastasises early, especially to regional lymph nodes. There is an ongoing debate on which early stage (T1-T2N0) patients should be treated with elective neck dissection. We need prognosticators for early stage tongue cancer. METHODS: Mice immunisation with human mesenchymal stromal cells resulted in production of antibodies against tenascin-C (TNC) and fibronectin (FN), which were used to stain 178 (98 early stage), oral tongue squamous cell carcinoma samples...
January 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28093860/monolithic-implant-supported-lithium-disilicate-ls2-crowns-in-a-complete-digital-workflow-a-prospective-clinical-trial-with-a-2-year-follow-up
#13
Tim Joda, Marco Ferrari, Urs Brägger
BACKGROUND: The technical development of digital processing allows the production of anatomically full-contoured implant-supported restorations. PURPOSE: The aim of this prospective clinical trial was to analyze the treatment concept of monolithic lithium disilicate (LS2) single-unit restorations in a complete digital workflow. MATERIAL AND METHODS: Forty-four patients were restored with 50 screw-retained monolithic implant LS2 crowns bonded to pre-fabricated titanium abutments on soft tissue level implants (Institut Straumann AG, Basel, Switzerland) in premolar and molar sites...
January 16, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28093721/application-of-autologous-hematopoietic-stem-cell-transplantation-for-pemphigus
#14
Menglei Wang, Can Cao, Jing Sun, Xuebiao Peng, Qifa Liu, Liang Huang, Yanyan Chai, Kuan Lai, Pingjiao Chen, Qingxiu Liu, Qian Li, Yusheng Peng, Hao Xiong, Jing Zhang, Minghua Chen, Kang Zeng
BACKGROUND: Pemphigus is a rare and fatal autoimmune disease for which the treatment options are limited. This study aimed to evaluate the efficacy of autologous peripheral hematopoietic stem cell transplantation (APHSCT) for pemphigus. METHODS: We conducted APHSCT for 12 pemphigus patients (seven males and five females, mean age 23.8 years) with life-threatening complications or who responded poorly to conventional therapy. Peripheral blood stem cells were mobilized with cyclophosphamide, granulocyte colony-stimulating factor, and rituximab, and purified autologous CD34(+) stem cells were infused...
January 17, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28093345/stereotactic-radiosurgery-srs-for-melanoma-brain-metastases-a-comprehensive-clinical-case-series
#15
Rui Feng, Eric K Oermann, Raj Shrivastava, Ariel Gold, Brian T Collins, Douglas Kondziolka, Sean P Collins
BACKGROUND: Melanoma has high propensity to metastasize to the brain. With recent gains in improving patient survival, stereotactic radiosurgery may offer an effective and less neurotoxic alternative to whole brain radiation. In the study, we report on the safety and efficacy of stereotactic radiosurgery (SRS) in treating melanoma brain metastases in 87 patients. METHODS: This retrospective, multicenter study examined 87 patients with 309 metastases underwent single-dose or multifractionated SRS for treatment of intracranial metastases from malignant melanoma...
January 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28092915/malignant-mixed-m%C3%A3-llerian-tumour-of-the-uterus-analysis-of-44-cases
#16
Silvana Grasso, Vera Loizzi, Valentina Minicucci, Leonardo Resta, Anna Lina Camporeale, Ettore Cicinelli, Gennaro Cormio
OBJECTIVES: The aim of our study was to evaluate the clinicopathological features and prognostic factors of uterine carcinosarcoma. PATIENTS AND METHODS: In this retrospective study, the clinical characteristics of 44 patients with uterine MMMT were evaluated. Survival curves were estimated by the Kaplan-Meier method and compared by the log-rank test. RESULTS: Forty-four patients with uterine carcinosarcoma were referred to our unit between 1995 and 2015...
January 17, 2017: Oncology
https://www.readbyqxmd.com/read/28092350/long-term-renal-survival-in-patients-undergoing-t-cell-depleted-versus-conventional-hematopoietic-stem-cell-transplants
#17
I G Glezerman, S Devlin, M Maloy, M Bui, E A Jaimes, S A Giralt, A A Jakubowski
Calcineurin inhibitor (CNI)-sparing T-cell depleted (TCD) hematopoietic stem cell transplants (HSCTs) are presumed to be less nephrotoxic than conventional HSCTs. We evaluated incidence and risk factors for kidney failure and chronic kidney disease (CKD) in 231 TCD and 212 conventional HSCT recipients. Kidney failure required a median glomerular filtration rate (GFR) <60 ml/min/1.73 m(2) for ⩾100 days anytime after 180-days post-HSCT. Two-year cumulative incidence (CI) of kidney failure was 42% in the conventional versus 31% in the TCD group (P=0...
January 16, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28090504/fortune-of-temporary-ileostomies-in-patients-treated-with-laparoscopic-low-anterior-resection-for-rectal-cancer
#18
Mustafa Haksal, Nuri Okkabaz, Ali Emre Atici, Osman Civil, Yasar Ozdenkaya, Ayhan Erdemir, Nihat Aksakal, Mustafa Oncel
PURPOSE: The current study aims to analyze the risk factors for the failure of ileostomy reversal after laparoscopic low anterior resection for rectal cancer. METHODS: All patients who underwent a laparoscopic low anterior resection for rectal cancer with a diverting ileostomy between 2007 and 2014 were abstracted. The patients who underwent and did not undergo a diverting ileostomy procedure were compared regarding patient, tumor, treatment related parameters, and survival...
January 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28090417/pattern-of-local-recurrence-and-distant-metastasis-in-breast-cancer-by-molecular-subtype
#19
Xingrao Wu, Ayesha Baig, Goulnar Kasymjanova, Kamran Kafi, Christina Holcroft, Hind Mekouar, Annie Carbonneau, Boris Bahoric, Khalil Sultanem, Thierry Muanza
BACKGROUND AND PURPOSE:  No longer considered a single disease entity, breast cancer is being classified into several distinct molecular subtypes based on gene expression profiling. These subtypes appear to carry prognostic implications and have the potential to be incorporated into treatment decisions. In this study, we evaluated patterns of local recurrence (LR), distant metastasis (DM), and association of survival with molecular subtype in breast cancer patients in the post-adjuvant radiotherapy setting...
December 9, 2016: Curēus
https://www.readbyqxmd.com/read/28088602/aggressive-surgical-approach-to-the-management-of-neuroendocrine-tumors-a-report-of-1-000-surgical-cytoreductions-by-a-single-institution
#20
Eugene A Woltering, Brianne A Voros, David T Beyer, Yi-Zarn Wang, Ramcharan Thiagarajan, Pamela Ryan, Anne Wright, Robert A Ramirez, M Jennifer Ricks, J Philip Boudreaux
BACKGROUND: Neuroendocrine tumors (NETs) are rare neoplasms. Our group has treated over 2,000 NET patients and has performed over 1,000 surgical cytoreductive procedures. STUDY DESIGN: Records of 834 NET patients who underwent surgical cytoreduction at our institution were reviewed. Demographic information, intraoperative findings, extent of disease, complications, and survival rates were calculated. RESULTS: 800 patients underwent 1,001 cytoreductive surgeries...
January 11, 2017: Journal of the American College of Surgeons
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