Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Ge Zhou, Jin Ren, Qiuyan Huang, Xiaowei Nie, Xingli Tong, Ya Wen Cui, Rongkui Hu, Qi Yao
RESEARCH QUESTION: Does the observed correlation between dyslipidaemia and endometriosis indicate a bidirectional causal association? DESIGN: Bidirectional Mendelian randomization was used to investigate the causal association between lipid traits and endometriosis. Drug-target Mendelian randomization was used to explore potential drug-target genes for managing endometriosis. In cases where lipid-mediated effects via specific drug targets were significant, aggregate analyses, such as summary-data-based Mendelian randomization and colocalization methods, were introduced to validate the outcomes...
February 2, 2024: Reproductive Biomedicine Online
#2
JOURNAL ARTICLE
Alyssa Hochberg, Michael H Dahan, Hakan Yarali, Lan N Vuong, Sandro C Esteves
RESEARCH QUESTION: What clinical factors are associated with 'unexpected' poor or suboptimal responses to IVF ovarian stimulation per POSEIDON's criteria, and which AMH and AFC threshold values distinguish this population? DESIGN: Tri-centre retrospective cohort study (2015-2017) involving first-time IVF and ICSI cycles with conventional ovarian stimulation (≥150 IU/day of FSH). Eligibility criteria included sufficient ovarian reserve markers according to POSEIDON's classification (AMH ≥1...
January 30, 2024: Reproductive Biomedicine Online
#3
JOURNAL ARTICLE
Niklas Klümper, Ngoc Khanh Tran, Stefanie Zschäbitz, Oliver Hahn, Thomas Büttner, Florian Roghmann, Christian Bolenz, Friedemann Zengerling, Constantin Schwab, Dora Nagy, Marieta Toma, Glen Kristiansen, Hendrik Heers, Philipp Ivanyi, Günter Niegisch, Camilla Marisa Grunewald, Christopher Darr, Arian Farid, Katrin Schlack, Mahmoud Abbas, Can Aydogdu, Jozefina Casuscelli, Theresa Mokry, Michael Mayr, Dora Niedersüß-Beke, Steffen Rausch, Dimo Dietrich, Jonas Saal, Jörg Ellinger, Manuel Ritter, Abdullah Alajati, Christoph Kuppe, Joshua Meeks, Francisco E Vera Badillo, J Alberto Nakauma-González, Joost Boormans, Kerstin Junker, Arndt Hartmann, Viktor Grünwald, Michael Hölzel, Markus Eckstein
PURPOSE: The anti-NECTIN4 antibody-drug conjugate enfortumab vedotin (EV) is approved for patients with metastatic urothelial cancer (mUC). However, durable benefit is only achieved in a small, yet uncharacterized patient subset. NECTIN4 is located on chromosome 1q23.3, and 1q23.3 gains represent frequent copy number variations (CNVs) in urothelial cancer. Here, we aimed to evaluate NECTIN4 amplifications as a genomic biomarker to predict EV response in patients with mUC. MATERIALS AND METHODS: We established a NECTIN4 -specific fluorescence in situ hybridization (FISH) assay to assess the predictive value of NECTIN4 CNVs in a multicenter EV-treated mUC patient cohort (mUC-EV, n = 108)...
April 24, 2024: Journal of Clinical Oncology
#4
JOURNAL ARTICLE
Jing Yang, Chen Yang, Jianju Feng, Fandong Zhu, Zhenhua Zhao
OBJECTIVE: This study aimed to explore the value of preoperative and postoperative computed tomography (CT)-based radiomic signatures and Δ radiomic signatures for evaluating the early efficacy of microwave ablation (MWA) for pulmonary malignancies. METHODS: In total, 115 patients with pulmonary malignancies who underwent MWA treatment were categorized into response and nonresponse groups according to relevant guidelines and consensus. Quantitative image features of the largest pulmonary malignancies were extracted from CT noncontrast scan images preoperatively (time point 0, TP0) and immediately postoperatively (time point 1, TP1)...
April 24, 2024: Journal of Computer Assisted Tomography
#5
JOURNAL ARTICLE
Nora E Rosenberg, Bonnie E Shook-Sa, Amber M Young, Yating Zou, Lynda Stranix-Chibanda, Marcel Yotebieng, Nadia A Sam-Agudu, Sam J Phiri, Wilbroad Mutale, Linda-Gail Bekker, Manhattan E Charurat, Sizulu Moyo, Khangelani Zuma, Jessica Justman, Michael G Hudgens, Benjamin H Chi
BACKGROUND: Women in Africa disproportionately acquire HIV-1. Understanding which women are most likely to acquire HIV-1 can guide focused prevention with pre-exposure prophylaxis (PrEP). Our objective is to identify women at highest risk of HIV-1 and estimate PrEP efficiency at different sensitivity levels. METHODS: Nationally representative data were collected from 2015-2019 from 15 population-based household surveys. This analysis included women aged 15-49 who tested HIV-1 sero-negative or had recent HIV-1...
April 24, 2024: Clinical Infectious Diseases
#6
JOURNAL ARTICLE
David J Sherman, Lei Liu, Jennifer L Mamrosh, Jiansong Xie, John Ferbas, Brett Lomenick, Mark S Ladinsky, Rati Verma, Ingrid C Rulifson, Raymond J Deshaies
Nonalcoholic fatty liver disease, recently renamed metabolic dysfunction-associated steatotic liver disease (MASLD), is a progressive metabolic disorder that begins with aberrant triglyceride accumulation in the liver and can lead to cirrhosis and cancer. A common variant in the gene PNPLA3 , encoding the protein PNPLA3-I148M, is the strongest known genetic risk factor for MASLD. Despite its discovery 20 y ago, the function of PNPLA3, and now the role of PNPLA3-I148M, remain unclear. In this study, we sought to dissect the biogenesis of PNPLA3 and PNPLA3-I148M and characterize changes induced by endogenous expression of the disease-causing variant...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
#7
JOURNAL ARTICLE
Sulemana Ansumah Saaka, Cornelius K A Pienaah, Zakara Stampp, Roger Antabe
Women are biologically more susceptible to the Human Immunodeficiency Virus (HIV) and other sexually transmitted Infections (STIs) because receptive sex is riskier than insertive. Despite condom use being the staple preventive method for HIV infection (over 80% efficacy), in Sub-Saharan African countries like Burkina Faso, a high burden of HIV and the unmet need for condom use coexist. Moreover, even though women in SSA are disproportionately HIV positive, they are reportedly less capable of negotiating condom use for HIV risk reduction...
2024: PLOS Glob Public Health
#8
JOURNAL ARTICLE
Lingyan Fang, Menglu Zhou, Fengkai Mao, Mengyuan Diao, Wei Hu, Guangyong Jin
BACKGROUND/AIM: We aimed to construct a validated nomogram model for predicting short-term (28-day) ischemic stroke mortality among critically ill populations. MATERIALS AND METHODS: We collected raw data from the Medical Information Mart for Intensive Care IV database, a comprehensive repository renowned for its depth and breadth in critical care information. Subsequently, a rigorous analytical framework was employed, incorporating a 10-fold cross-validation procedure to ensure robustness and reliability...
2024: PloS One
#9
JOURNAL ARTICLE
Joseph Zoller, Steve Horvath
MOTIVATION: Epigenetic clocks are prediction methods based on DNA methylation levels in a given species or set of species. Defined as multivariate regression models, these DNA methylation-based biomarkers of age or mortality risk are useful in species conservation efforts and in preclinical studies. RESULTS: We present an R package called MammalMethylClock for the construction, assessment, and application of epigenetic clocks in different mammalian species. The R package includes the utility for implementing pre-existing mammalian clocks from the Mammalian Methylation Consortium...
April 24, 2024: Bioinformatics
#10
JOURNAL ARTICLE
Michele Bottosso, Federica Miglietta, Grazia Maria Vernaci, Tommaso Giarratano, Maria Vittoria Dieci, Valentina Guarneri, Gaia Griguolo
Adjuvant endocrine therapy represents the standard of care for almost all HR+/HER2- breast cancers and different agents and durations are currently available. In this context, the tailoring and optimization of adjuvant endocrine treatment by reducing unnecessary toxic treatment while taking into account the biological heterogeneity of HR+/HER2- breast cancer represents a clinical priority. There is therefore a significant need for the integration of biological biomarkers in the choice of adjuvant endocrine therapy beyond currently used clinicopathological characteristics...
April 24, 2024: Clinical Cancer Research
#11
JOURNAL ARTICLE
Luigi Rizzi, Chiara Coppola, Yaqob Hbaidi, Riccardo Russo, Lucilla Crudele, Antonio Moschetta, Patrizia Suppressa
Sarcoidosis is a rare granulomatous disease that can affect any organ. It leads to an increased risk of metabolic syndrome and insulin resistance, due to biochemical pathways involved in low-grade inflammation in both diseases. The aim of our retrospective case-control study was to evaluate the utility of triglyceride-glucose (TyG) index, a surrogate of insulin resistance, for metabolic assessment of sarcoidosis patients. A cohort of 90 sarcoidosis patients and a cohort of 90 control subjects were enrolled...
April 24, 2024: Internal and Emergency Medicine
#12
REVIEW
Hua-Jay J Cherng, Alex Herrera
Diffuse large B-cell lymphoma (DLBCL) is a curable disease with variable outcomes due to underlying heterogeneous clinical and molecular features-features that are insufficiently characterized with our current tools. Due to these limitations, treatment largely remains a "one-size-fits-all" approach. Circulating tumor DNA (ctDNA) is a novel biomarker in cancers that is increasingly utilized for risk stratification and response assessment. ctDNA is readily detectable from the plasma of patients with DLBCL but has not yet been incorporated into clinical care to guide treatment...
April 24, 2024: Current Treatment Options in Oncology
#13
JOURNAL ARTICLE
Inès Elhani, Pascal Heydacker, Anne-Sophie Tavernier, Sophie Georgin-Lavialle, Véronique Hentgen
INTRODUCTION: Familial Mediterranean fever (FMF) is the most frequent monogenic auto-inflammatory disease worldwide responsible for episodes of fever, serositis and musculoskeletal symptoms. Inflammatory attacks are responsible for sedentary behavior and FMF patients may be at increased cardiovascular risk. Cardiorespiratory Fitness (CRF) and physical capacities during adolescence are associated with cardiovascular mortality in adulthood. In this study, we aimed to describe the physical fitness of FMF adolescents...
April 24, 2024: Rheumatology International
#14
JOURNAL ARTICLE
Wanyu Jia, Xue Zhang, Peng Li, Ruiyang Sun, Daobin Wang, Chunlan Song
INTRODUCTION: The occurrence of pulmonary consolidation in children with Mycoplasma pneumoniae pneumonia (MPP) can lead to exacerbation of the disease. Therefore, early identification of children with MPP in combination with pulmonary consolidation is critical. The purpose of this study was to develop a straightforward, easy-to-use online dynamic nomogram for the identification of children with MPP who are at high risk of developing pulmonary consolidation. METHODS: 491 MPP patients were chosen and divided randomly into a training cohort and an internal validation cohort at a 4:1 ratio...
April 24, 2024: European Journal of Clinical Microbiology & Infectious Diseases
#15
JOURNAL ARTICLE
Oğuzhan Oruz, Mehmet Serdar Dervişoğulları, Müzeyyen Ezgi Öktem, Caner İncekaş
PURPOSE: To search the relationship between serum neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) values with the development of retinopathy of prematurity (ROP) and the requirement for laser treatment. METHODS: This retrospective cohort study was carried out with 195 preterm infants between 2012 and 2023. The NLR, PLR, LMR, and SII values were calculated on both the first day and at the end of the first month after birth...
April 24, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
#16
JOURNAL ARTICLE
Yi-Shin Chang, Kai Huang, Jessica M Lee, Christen L Vagts, Christian Ascoli, Md-Ruhul Amin, Mahmood Ghassemi, Claudia M Lora, Russell Edafetanure-Ibeh, Yue Huang, Ruth A Cherian, Nandini Sarup, Samantha R Warpecha, Sunghyun Hwang, Rhea Goel, Benjamin A Turturice, Cody Schott, Montserrat Hernandez, Yang Chen, Julianne Jorgensen, Wangfei Wang, Mladen Rasic, Richard M Novak, Patricia W Finn, David L Perkins
BACKGROUND: End-stage renal disease (ESRD) patients experience immune compromise characterized by complex alterations of both innate and adaptive immunity, and results in higher susceptibility to infection and lower response to vaccination. This immune compromise, coupled with greater risk of exposure to infectious disease at hemodialysis (HD) centers, underscores the need for examination of the immune response to the COVID-19 mRNA-based vaccines. METHODS: The immune response to the COVID-19 BNT162b2 mRNA vaccine was assessed in 20 HD patients and cohort-matched controls...
April 24, 2024: ELife
#17
JOURNAL ARTICLE
Daniel H Strauss, Natalie M Davoodi, Linda J Resnik, Sarah Keene, Peter T Serina, Elizabeth M Goldberg
BACKGROUND AND PURPOSE: Falls are the leading reason for injury-related emergency department (ED) visits for older adults. The Geriatric Acute and Post-acute Fall Prevention Intervention (GAPcare), an in-ED intervention combining a medication therapy management session delivered by a pharmacist and a fall risk assessment and plan by a physical therapist, reduced ED revisits at 6 months among older adults presenting after a fall. Our objective was to evaluate the relationship between measures of function obtained in the ED and clinical outcomes...
April 24, 2024: Journal of Geriatric Physical Therapy
#18
JOURNAL ARTICLE
Yangyang Yang, Xiaoyan Yin, Yuanzhuo Zhang, Lei Ren
PURPOSE: Construction of a prediction model to predict the risk of major adverse cardiovascular events (MACE) in the long term after percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI). METHOD: Retrospective analysis of STEMI patients treated with PCI from April 2018 to April 2021 in Fuyang People's Hospital. Lasso regression was used to screen the risk factors for the first occurrence of MACE in patients, and multifactorial logistic regression analysis was used to construct a prediction model...
April 25, 2024: Coronary Artery Disease
#19
JOURNAL ARTICLE
Qian Wei, Xuefeng Lu, Zihong Yang, Jichong Zhu, Jie Jiang, Yaobin Xu, Fengxin Li, Haifeng Bu, Yikai Chen, Sijing Tuo, Ruyu Chen, Xiaoxia Ye, Laoyi Geer, Xiuwei Tan, Jiling Wang, Yanlan Wu, Fangming Song, Yiji Su
OBJECTIVE: This study aimed to establish a nomogram-based assessment for predicting the risk of hyponatremia after spinal cord injury (SCI). DESIGN: The study is a retrospective single-center study. PARTICIPANTS: SCI patients hospitalized in the First Affiliated Hospital of Guangxi Medical University. SETTING: The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. METHODS: We performed a retrospective clinical study to collect SCI patients hospitalized in the First Affiliated Hospital of Guangxi Medical University from 2016 to 2020...
April 24, 2024: Journal of Spinal Cord Medicine
#20
JOURNAL ARTICLE
Tyrone G Harrison, Meghan J Elliott, Marcello Tonelli
PURPOSE OF REVIEW: Personalized approaches to care are increasingly common in clinical nephrology. Although risk prediction models are developed to estimate the risk of kidney-disease related outcomes, they infrequently consider the priorities of patients they are designed to help. RECENT FINDINGS: This review discusses certain steps in risk prediction tool development where patients and their priorities can be incorporated. Considering principles of equity throughout the process has been the focus of recent literature...
April 25, 2024: Current Opinion in Nephrology and Hypertension
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
