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https://www.readbyqxmd.com/read/29228516/refining-prediction-in-treatment-resistant-depression-results-of-machine-learning-analyses-in-the-trd-iii-sample
#1
Alexander Kautzky, Markus Dold, Lucie Bartova, Marie Spies, Thomas Vanicek, Daniel Souery, Stuart Montgomery, Julien Mendlewicz, Joseph Zohar, Chiara Fabbri, Alessandro Serretti, Rupert Lanzenberger, Siegfried Kasper
OBJECTIVE: The study objective was to generate a prediction model for treatment-resistant depression (TRD) using machine learning featuring a large set of 47 clinical and sociodemographic predictors of treatment outcome. METHOD: 552 Patients diagnosed with major depressive disorder (MDD) according to DSM-IV criteria were enrolled between 2011 and 2016. TRD was defined as failure to reach response to antidepressant treatment, characterized by a Montgomery-Asberg Depression Rating Scale (MADRS) score below 22 after at least 2 antidepressant trials of adequate length and dosage were administered...
December 5, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29228514/gait-speed-predicts-post-operative-medical-complications-in-elderly-gastric-cancer-patients-undergoing-gastrectomy
#2
Arvine Chandoo, Chu-Huai Chi, Weiping Ji, Yingpeng Huang, Xiao-Dong Chen, Wei-Teng Zhang, Rui-Sen Wu, Xian Shen
BACKGROUND: Gait speed is a clinical outcome that can measure the physical performance of elderly gastric patients. The purpose of this study was to determine the importance of gait speed in predicting post-operative morbidities in elderly patients undergoing curative gastrectomy. METHODS: We conducted a prospective study of 357 elderly patients (≥65 years old) undergoing curative gastrectomy. Preoperative gait speed was measured in a 6-m well-lit and unobstructed hallway...
December 11, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29228458/seeing-the-signs-using-the-course-of-residual-depressive-symptomatology-to-predict-patterns-of-relapse-and-recurrence-of-major-depressive-disorder
#3
Floor E A Verhoeven, Klaas J Wardenaar, Henricus G Eric Ruhé, Henk Jan Conradi, Peter de Jonge
BACKGROUND: Major depressive disorder (MDD) is characterized by high relapse/recurrence rates. Predicting individual patients' relapse/recurrence risk has proven hard, possibly due to course heterogeneity among patients. This study aimed to (1) identify homogeneous data-driven subgroups with different patterns of relapse/recurrence and (2) identify associated predictors. METHODS: For a year, we collected weekly depressive symptom ratings in 213 primary care MDD patients...
December 11, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29228455/prognostic-significance-of-neoadjuvant-rectal-score-in-locally-advanced-rectal-cancer-after-neoadjuvant-chemoradiotherapy-and-construction-of-a-prediction-model
#4
Yanwu Sun, Yiyi Zhang, Xuejing Wu, Huiming Lin, Xingrong Lu, Ying Huang, Zongbin Xu, Shenghui Huang, Xiaojie Wang, Pan Chi
AIM: To evaluate the prognostic significance of neoadjuvant rectal (NAR) score after neoadjuvant chemoradiotherapy (nCRT) for locally advanced rectal cancer (LARC), and to develop a nomogram predicting disease-free survival (DFS). METHOD: A total of 522 LARC patients undergoing nCRT and surgery were included. NAR scores were calculated using the equation [5pN-3(cT-pT) + 12]^2/9.61, and classified as low (<8), intermediate (8-16), and high (>16). Clinicopathological and survival outcomes were compared...
December 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29228452/establishment-and-analysis-of-the-prediction-model-for-cervical-squamous-cell-carcinoma
#5
Y-H Zhou, W-F Fan, J Deng, H-L Xi
OBJECTIVE: This study aimed to construct a prediction model for cervical squamous cell carcinoma and evaluate its accuracy in diagnosing cervical squamous cell carcinoma. PATIENTS AND METHODS: Fifty patients with initially histopathologically confirmed cervical squamous cell carcinoma and 150 patients with initially histopathologically confirmed cervical intraepithelial neoplasia (CIN) were enrolled. The high-risk human papillomavirus (HR-HPV) infection, human telomerase mRNA component (hTERC) gene and cell-myc (c-myc) gene amplification, and minichromosome maintenance protein 5 (MCM5) protein expression were detected...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228413/estimating-vector-borne-viral-infections-in-the-urban-setting-of-the-2020-tokyo-olympics-japan-using-mathematical-modeling
#6
Hiroyuki Furuya
The first domestic outbreak of dengue fever in Japan since 1945 was reported in Tokyo in 2014. Meanwhile, daily mean summer temperatures are expected to continue to rise world-wide. Such conditions are expected to increase the risk of an arbovirus outbreak at the 2020 Tokyo Olympic Games. To address this possibility, the present study compared estimates of the risk of infection by dengue, chikungunya, and Zika viruses in urban areas. To compare the risk of infection by arboviruses transmitted by Ae. albopictus mosquitoes, the reproduction number for each of three arboviruses was estimated under the environmental conditions associated with the 2014 dengue outbreak in Tokyo, and additionally under conditions assuming a daily mean temperature elevation of 2° C...
December 20, 2017: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/29228242/mortality-risk-prediction-in-infective-endocarditis-surgery-reliability-analysis-of-specific-scores
#7
Laura Varela, Jose López-Menéndez, Ana Redondo, Edmundo Ricardo Fajardo, Javier Miguelena, Tomasa Centella, Miren Martín, Rafael Muñoz, Enrique Navas, Jose Luis Moya, Jorge Rodríguez-Roda
OBJECTIVES: We assessed the prognostic utility of risk scores in surgery for infective endocarditis (IE) to evaluate their reliability in mortality risk prediction. METHODS: An observational retrospective study was developed to include all patients who underwent surgery for active IE from 2002 to 2016. Classical and endocarditis-specific risk scores were calculated. RESULTS: A total of 180 patients were included in the study. The 30-day mortality rate was 26...
December 8, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29228203/in-vivo-cholinergic-basal-forebrain-atrophy-predicts-cognitive-decline-in-de-novo-parkinson-s-disease
#8
Nicola J Ray, Steven Bradburn, Christopher Murgatroyd, Umar Toseeb, Pablo Mir, George K Kountouriotis, Stefan J Teipel, Michel J Grothe
Cognitive impairments are a prevalent and disabling non-motor complication of Parkinson's disease, but with variable expression and progression. The onset of serious cognitive decline occurs alongside substantial cholinergic denervation, but imprecision of previously available techniques for in vivo measurement of cholinergic degeneration limit their use as predictive cognitive biomarkers. However, recent developments in stereotactic mapping of the cholinergic basal forebrain have been found useful for predicting cognitive decline in prodromal stages of Alzheimer's disease...
December 8, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29228122/tennessee-s-in-state-vulnerability-assessment-for-a-rapid-dissemination-of-hiv-or-hcv-infection-event-utilizing-data-about-the-opioid-epidemic
#9
Michael Rickles, Peter F Rebeiro, Lindsey Sizemore, Paul Juarez, Mitchell Mutter, Carolyn Wester, Melissa McPheeters
Background: Knowing which factors contribute to county-level vulnerability to an HIV/Hepatitis C (HCV) outbreak, and which counties are most vulnerable, guide public health and clinical interventions. We therefore examined the impact of locally available indicators related to the opioid epidemic on prior national models of HCV/HIV outbreak vulnerability. Methods: Tennessee's 95 counties were the study sample. Predictors from 2012 and 2013 were used, mirroring prior methodology from the US Centers for Disease Control and Prevention (CDC)...
December 7, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29227997/normalized-emphysema-scores-on-low-dose-ct-validation-as-an-imaging-biomarker-for-mortality
#10
Leticia Gallardo-Estrella, Esther Pompe, Pim A de Jong, Colin Jacobs, Eva M van Rikxoort, Mathias Prokop, Clara I Sánchez, Bram van Ginneken
The purpose of this study is to develop a computed tomography (CT) biomarker of emphysema that is robust across reconstruction settings, and evaluate its ability to predict mortality in patients at high risk for lung cancer. Data included baseline CT scans acquired between August 2002 and April 2004 from 1737 deceased subjects and 5740 surviving controls taken from the National Lung Screening Trial. Emphysema scores were computed in the original scans (origES) and after applying resampling, normalization and bullae analysis (normES)...
2017: PloS One
https://www.readbyqxmd.com/read/29227977/red-blood-cell-distribution-width-is-an-independent-predictor-of-aki-and-mortality-in-patients-in-the-coronary-care-unit
#11
Yugang Hu, Huilan Liu, Shuai Fu, Jing Wan, Xiaoning Li
BACKGROUND/AIMS: We investigated the hypothesis that RDW is an independent predictor of acute kidney injury (AKI) and mortality in patients in the coronary care unit (CCU). METHODS: In this prospective, observational study, we screened 412 adults admitted to the CCU at Zhongnan Hospital of Wuhan University from January 1, 2014 to June 1, 2015. AKI was defined based on the KDIGO-AKI criteria. The survivors were followed up for up to 2 years after hospital discharge...
December 8, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29227938/the-cumulative-effect-of-air-pollutants-on-the-acute-exacerbation-of-copd-in-shanghai-china
#12
Xian Wen Sun, Pei Li Chen, Lei Ren, Ying Ni Lin, Jian Ping Zhou, Lei Ni, Qing Yun Li
BACKGROUND: Epidemiologic studies have shown the effect of air pollutants on acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, little is known regarding the dose-response relationship. This study aimed to investigate the cumulative effect of air pollutants on AECOPD. METHODS: We collected 101 patients with AECOPD from November 2010 through August 2011 in Shanghai. Multiple logistic regression was used to estimate associations between air pollutants and AECOPD...
December 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29227730/physical-and-performance-characteristics-related-to-unintentional-musculoskeletal-injury-in-special-forces-operators-a-prospective-analysis
#13
Nicholas R Heebner, John P Abt, Mita Lovalekar, Kim Beals, Timothy C Sell, Jeffery Morgan, Shawn Kane, Scott Lephart
CONTEXT:   Seventy-seven percent of musculoskeletal injuries sustained by United States Army Special Forces Operators are preventable. Identification of predictive characteristics will promote the development of screening methods to augment injury-prevention programs. OBJECTIVE:   To determine physical and performance characteristics that predict musculoskeletal injuries. SETTING:   Clinical laboratory. PATIENTS OR OTHER PARTICIPANTS:   A total of 95 Operators (age = 32...
December 11, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/29227583/single-point-mutation-on-the-gene-encoding-dysbindin-results-in-recognition-deficits
#14
Eric H Chang, Kayla Fernando, Lok Wan E Yeung, Kristina Barbari, Toni-Shay S Chandon, Anil K Malhotra
The dystrobrevin-binding protein 1 (DTNBP1) gene is a candidate risk factor for schizophrenia and has been associated with cognitive ability in both patient populations and healthy controls. DTNBP1 encodes dysbindin protein, which is localized to synaptic sites and is reduced in the prefrontal cortex and hippocampus of patients with schizophrenia, indicating a potential role in schizophrenia etiology. Most studies of dysbindin function have focused on the sandy (sdy) mice that lack dysbindin protein and have a wide range of abnormalities...
December 11, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29227531/discovery-of-a-novel-six-long-non-coding-rna-signature-predicting-survival-of-colorectal-cancer-patients
#15
Qiaowei Fan, Bingrong Liu
Colorectal cancer (CRC) is one of the most leading causes of cancer deaths worldwide. In the study, we aimed to identify key long non-coding RNAs (lncRNAs) significantly associated with prognosis of CRC and develop an expression-based lncRNA signature to provide surviv-al risk prediction for CRC patients. LncRNA expression profiles and clinical information of CRC patients were collected from The Cancer Genome Atlas (TCGA) database. 618 differen-tially expressed lncRNAs were identified between CRC and normal tissues...
December 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29227462/psychiatric-disorders-antiretroviral-medication-adherence-and-viremia-in-a-cohort-of-perinatally-hiv-infected-adolescents-and-young-adults
#16
Amelia Bucek, Cheng-Shiun Leu, Stephanie Benson, Patricia Warne, Elaine J Abrams, Katherine S Elkington, Curtis Dolezal, Andrew Wiznia, Claude Ann Mellins
BACKGROUND: Perinatally HIV-infected (PHIV+) adolescents and young adults (AYA) are at risk for sub-optimal antiretroviral therapy (ART) adherence, and mental health and substance use problems that, in HIV-infected adults, predict non-adherence. Studies on the relationship between psychiatric and substance use disorders (SUD) and adherence among PHIV+ AYA are limited, but may be important to informing evidence-based interventions to promote adherence. METHODS: Data were analyzed from three annual follow-up interviews (FU2-4, N=179) in a longitudinal study of PHIV+ AYA...
December 8, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29227437/reducing-childhood-admissions-to-the-picu-for-poisoning-recap2-by-predicting-unnecessary-picu-admissions-after-acute-intoxication
#17
Meral M Patel, Curtis D Travers, Jana A Stockwell, Ezaldeen A Numur, Robert J Geller, Pradip P Kamat, Jocelyn R Grunwell
OBJECTIVE: To derive and validate clinical prediction models to identify children at low risk of clinically significant intoxications for whom intensive care admission is unnecessary. DESIGN: Retrospective review of data in the National Poison Data Systems from 2011 to 2014 and Georgia Poison Center cases from July to December 2016. SETTING: United States PICUs and poison centers participating in the American Association of Poison Control Centers from 2011 to 2016...
December 8, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29227335/usefulness-of-the-braden-scale-in-intensive-care-units-a-study-based-on-electronic-health-record-data
#18
Yi Na Han, Jung Eun Choi, Yin Ji Jin, Tai Xian Jin, Sun-Mi Lee
Nurses working in intensive care units have expressed concern that some categories of the Braden scale such as activity and nutrition are not suitable for intensive care unit patients. Upon examining the validity of the Braden scale using the electronic health data, we found relatively low predictability of the tool. Risk factors from the sensory perception and activity categories were not associated with risk of pressure ulcers.
December 8, 2017: Journal of Nursing Care Quality
https://www.readbyqxmd.com/read/29227306/big-data-analytical-approaches-to-the-nacc-dataset-aiding-preclinical-trial-enrichment
#19
Ming Lin, Pinghua Gong, Tao Yang, Jieping Ye, Roger L Albin, Hiroko H Dodge
BACKGROUND: Clinical trials increasingly aim to retard disease progression during presymptomatic phases of Mild Cognitive Impairment (MCI) and thus recruiting study participants at high risk for developing MCI is critical for cost-effective prevention trials. However, accurately identifying those who are destined to develop MCI is difficult. Collecting biomarkers is often expensive. METHODS: We used only noninvasive clinical variables collected in the National Alzheimer's Coordinating Center (NACC) Uniform Data Sets version 2...
December 7, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29227235/drinking-motives-and-alcohol-use-the-serve-study-of-u-s-current-and-former-service-members
#20
Cynthia D Mohr, Cameron T McCabe, Sarah N Haverly, Leslie B Hammer, Kathleen F Carlson
OBJECTIVE: Hazardous drinking in the armed forces is a significant problem. Alcohol use motivations, known risk factors for problem drinking, have been underexplored in this population. Our study extends knowledge about drinking motives among current and former U.S. service members and provides recommendations on their utility in identifying alcohol-related problems by examining the factor structure of multidimensional drinking motives and their association to alcohol use. METHOD: Post-9/11 separated service members and current reservists were recruited from 35 Oregon employers to participate in a workplace study of supervisor support...
January 2018: Journal of Studies on Alcohol and Drugs
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