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https://www.readbyqxmd.com/read/29049548/multimodal-analgesia-in-outpatient-head-and-neck-surgery-a-feasibility-and-safety-study
#1
Justin Oltman, Oleg Militsakh, Mark D'Agostino, Brittany Kauffman, Robert Lindau, Andrew Coughlin, William Lydiatt, Daniel Lydiatt, Russell Smith, Aru Panwar
Importance: Perioperative analgesia strategies that rely solely on narcotics may contribute to adverse effects and concerns about opioid abuse or dependence. Multimodal analgesia protocols incorporating nonnarcotic agents may reduce the need for postoperative narcotic use. Objective: To evaluate the feasibility and safety of a multimodal analgesia protocol for outpatient head and neck surgical procedures and to identify the association of the multimodal analgesia protocol with postoperative pain perception scores and patient satisfaction...
October 19, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29049191/significance-of-monitoring-plasma-concentration-of-voriconazole-in-a-patient-with-liver-failure-a-case-report
#2
Xiaoyan Liu, Haibin Su, Jingjing Tong, Jing Chen, Haozhen Yang, Long Xiao, Jinhua Hu, Lina Zhang
RATIONALE: Invasive pulmonary aspergillosis is associated with significant morbidity and mortality in patients with liver failure. Voriconazole (VRCZ) is recommended as a primary therapeutic agent for the treatment of invasive aspergillosis and metabolized in the liver. Now, data are still lacking on the safety and appropriate dosage of VRCZ in patients with liver failure. Here, we report a representative case of invasive pulmonary fungal infection in a patient with liver failure who was treated with low-dose VRCZ...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049005/beliefs-attitudes-and-activities-of-healthcare-personnel-about-influenza-and-pneumococcal-vaccines
#3
Fatma Çiftci, Elif Şen, Nalan Demir, Orçun Çiftci, Serhat Erol, Oya Kayacan
OBJECTIVES: Vaccination of healthcare personnel (HCP) is an effective measure for preventing the spread of influenza among at-risk patients. This study was conducted to determine influenza vaccination rates and activities among HCP working at a tertiary healthcare setting. METHODS: This study included 470 HCP (85 physicians, 134 nurses, 53 healthcare assistants, 44 paramedics, 47 medical secretaries, and 107 auxillary staff members) working at the emergency, cardiology, chest diseases, and internal medicine departments with the largest volume of patients with vaccination indication of two large university hospitals with similar medical practices and work environment...
October 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29048451/definition-of-criteria-and-indicators-for-the-prevention-of-healthcare-associated-infections-hais-in-hospitals-for-the-purposes-of-italian-institutional-accreditation-and-performance-monitoring
#4
S Tardivo, F Moretti, M Nobile, A Agodi, R Appignanesi, C Arrigoni, T Baldovin, S Brusaferro, R Canino, A Carli, R Chiesa, D D'Alessandro, M M D'Errico, G Giuliani, M T Montagna, M Moro, I I Mura, R Novati, G B Orsi, C Pasquarella, G Privitera, G Ripabelli, A Rossini, M Saia, L Sodano, M V Torregrossa, E Torri, R Zarrilli, F Auxilia, Gisio SItI
BACKGROUND: Healthcare-associated infections (HAIs) are an important issue in terms of quality of care. HAIs impact patient safety by contributing to higher rates of preventable mortality and prolonged hospitalizations. In Italy, analysis of the currently available accreditation systems shows a substantial heterogeneity of approaches for the prevention and surveillance of HAIs in hospitals. The aim of the present study is to develop and propose the use of a synthetic assessment tool that could be implemented homogenously throughout the nation...
November 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29047342/effectiveness-and-patient-safety-of-platelet-aggregation-inhibitors-in-the-prevention-of-cardiovascular-disease-and-ischemic-stroke-in-older-adults-a-systematic-review
#5
REVIEW
Maren Meinshausen, Anja Rieckert, Anna Renom-Guiteras, Moritz Kröger, Christina Sommerauer, Ilkka Kunnamo, Yolanda V Martinez, Aneez Esmail, Andreas Sönnichsen
BACKGROUND: Platelet aggregation inhibitors (PAI) are among the most frequently prescribed drugs in older people, though evidence about risks and benefits of their use in older adults is scarce. The objectives of this systematic review are firstly to identify the risks and benefits of their use in the prevention and treatment of vascular events in older adults, and secondly to develop recommendations on discontinuing PAI in this population if risks outweigh benefits. METHODS: Staged systematic review consisting of three searches...
October 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29047301/pimavanserin-novel-pharmacotherapy-for-parkinson-s-disease-psychosis
#6
Zeyad T Sahli, Frank I Tarazi
Pimavanserin is the first FDA-approved atypical antipsychotic drug indicated for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis (PDP). Areas covered: This review focuses on the preclinical discovery of pimavanserin. It analyzes the pharmacological, behavioral and molecular mechanisms of pimavanserin and their contribution to the therapeutic advantages of the drug as reported in published preclinical and clinical studies, and product labels. Expert opinion: Pimavanserin exhibits a unique pharmacological profile with nanomolar affinity at serotonin 5-HT2A and 5-HT2C receptors...
October 19, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29044065/the-adverse-effects-of-valproic-acid-on-visual-functions-in-the-treatment-of-retinitis-pigmentosa
#7
Yüksel Totan, Emre Güler, Aslıhan Yüce, Mehmet Serdar Dervişogulları
PURPOSE: To evaluate the efficacy and safety of valproic acid (VPA) treatment in patients with retinitis pigmentosa (RP). METHODS: A total of 48 eyes of 24 patients (13 males, 11 females) with RP prescribed VPA were included. The length of VPA treatment was 6-12 months (mean 9.4 months). Parameters evaluated were best-corrected visual acuity (BCVA) (logarithm of the minimum angle of resolution [logMAR]), visual field analyses (VFAs) with Humprey automated perimetry, multifocal electroretinography (ERG) with Roland-RETI scan, and VPA side effects...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29043436/cervical-dilation-balloon-combined-with-intravenous-drip-of-oxytocin-for-induction-of-term-labor-a-multicenter-clinical-trial
#8
Xueqin Wu, Chunxiang Wang, Yufang Li, Chunmei Ouyang, Jiaying Liao, Weibin Cai, Yilei Zhong, Jianping Zhang, Hui Chen
OBJECTIVE: This study aimed to investigate the effectiveness and safety of a method combining double-balloon catheter for cervical ripening and intravenous drip of oxytocin on the induction of term labor, providing the reference for clinical safety. METHODS: A total of 120 pregnant women with a gestation between 37(+0) and  41(+6) weeks, indications of labor induction, singleton pregnancy with cephalic presentation were enrolled. The patients were divided into the research group receiving cervical dilation balloon combined with intravenous drip of oxytocin and the control group receiving an intravenous drip of oxytocin at a concentration of 0...
October 17, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29042967/a-case-control-study-on-the-treatment-of-protrusion-of-lumbar-intervertebral-disc-through-peld-and-med
#9
Hong-Pu Song, Hong-Feng Sheng, Wei-Xing Xu
We compared the clinical effects between the percutaneous endoscopic lumbar discectomy (PELD) and microendoscopic discectomy (MED) treatments for protrusion of lumbar intervertebral disc. We conducted a retrospective analysis on 60 patients who were diagnosed with single-segment protrusion of lumbar intervertebral disc during the period from January 2009 to June 2016. Patients were divided into two groups, the PELD and MED groups, which contained 30 cases each. We evaluated the operation results according to oswestry dysfunction index (ODI), visual analogue scale (VAS) and the improved MacNab standard...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042806/feeding-filaggrin-effects-of-l-histidine-supplementation-in-atopic-dermatitis
#10
Siao Pei Tan, Simon B Brown, Christopher Em Griffiths, Richard B Weller, Neil K Gibbs
Atopic dermatitis (AD), also known as eczema, is one of the most common chronic skin conditions worldwide, affecting up to 16% of children and 10% of adults. It is incurable and has significant psychosocial and economic impacts on the affected individuals. AD etiology has been linked to deficiencies in the skin barrier protein, filaggrin. In mammalian skin, l-histidine is rapidly incorporated into filaggrin. Subsequent filaggrin proteolysis releases l-histidine as an important natural moisturizing factor (NMF)...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29038880/ct-guided-percutaneous-ethanol-sympatholysis-for-primary-hyperhidrosis
#11
Malcolm Brock, Constantine Frangakis, Christos S Georgiades
PURPOSE: Primary hyperhidrosis (PH) typically involves the craniofacial (CF) or axillary-palmar (AP) region. Our purpose was to determine the safety and efficacy of CT-guided sympatholysis for treating PH. METHODS: In this prospective study, 39 consecutive patients with CF or AP PH were referred for percutaneous sympatholysis. Procedures were performed under CT guidance and minimal sedation. We treated level T2 for CF hyperhidrosis and T2, T3, and T4 for AP hyperhidrosis...
October 16, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29038432/efficacy-and-safety-for-apatinib-treatment-in-advanced-gastric-cancer-a-real-world-study
#12
Yong Zhang, Chun Han, Juan Li, Li Zhang, Lijie Wang, Sisi Ye, Yi Hu, Li Bai
Apatinib has been proved to be effective and safe among patients in gastric cancer in Phase II and III Trials. We aimed to evaluate its efficacy and safety in real world practice, and to explore factors associated with efficacy. Between January 2015 and February 2017, totally 36 patients with advanced gastric adenocarcinoma or adenocarcinoma of gastroesophageal junction (GEJ) were enrolled and followed up retrospectively after failing at least two lines of systemic therapy. The mPFS was 2.65 months (95%CI 1...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29036810/naturalizing-activity-and-safety-of-human-monoclonal-antibodies-against-of-hepatitis-c-virus
#13
Tawfeek H Abelhafez, Ashraf A Tabll, Mostafa K El-Awady, Mohammad M Mashaly, Reem El Shenawy, Yasmine S El-Abd, Maysa H Shaker, Camelia A Abdel Malak
AIM: Assessment of neutralizing activity of the human monoclonal antibodies against HCV and also study its safety in experimental small animals (Swiss mice). MATERIALS AND METHODS: Assessment of neutralizing activity of the human monoclonal antibodies against HCV envelope regions (E1, E2) by two methods (by HCV cc infectious system and by using positive HCV positive serum as source of HCV particles (neutralizing assay 2). Dot ELISA were used to study the activity of the generated antibodies...
September 29, 2017: Human Antibodies
https://www.readbyqxmd.com/read/29036505/increased-mortality-in-haemodialysis-patients-administered-high-doses-of-erythropoiesis-stimulating-agents-a-propensity-score-matched-analysis
#14
Rafael Pérez-García, Javier Varas, Alejandro Cives, Alejandro Martín-Malo, Pedro Aljama, Rosa Ramos, Julio Pascual, Stefano Stuard, Bernard Canaud, José Ignacio Merello
Background: Erythropoiesis-stimulating agents (ESAs) are widely used to treat anaemia in patients with chronic kidney disease. The issue of ESA safety has been raised in multiple studies, with correlates derived for elevated cancer incidence and mortality. Whether these associations are related to ESA dose or the typology of the patient remains obscure. Methods: A multicentre, observational retrospective propensity score-matched study was designed to analyse the effects of weekly ESA dose in 1679 incident haemodialysis (HD) patients...
September 28, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29036016/exercise-preserves-physical-function-in-prostate-cancer-patients-with-bone-metastases
#15
Daniel A Galvão, Dennis R Taaffe, Nigel Spry, Prue Cormie, David Joseph, Suzanne K Chambers, Raphael Chee, Carolyn Peddle-McIntyre, Nicolas H Hart, Freerk T Baumann, James Denham, Michael Baker, Robert U Newton
PURPOSE: The presence of bone metastases has excluded participation of cancer patients in exercise interventions and is a relative contraindication to supervised exercise in the community setting due to concerns of fragility fracture. We examined the efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases. METHODS: Between 2012 and 2015, 57 prostate cancer patients (70.0±8.4 years; BMI 28.7±4.0 kg/m) with bone metastases (pelvis 75...
October 14, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29035966/effectiveness-of-rifampicin-chemoprophylaxis-in-preventing-leprosy-in-patient-contacts-a-systematic-review-of-quantitative-and-qualitative-evidence
#16
Silvana Margarida Benevides Ferreira, Tatiana Yonekura, Eliane Ignotti, Larissa Bertacchini de Oliveira, Juliana Takahashi, Cassia Baldini Soares
BACKGROUND: Individuals in contact with patients who have leprosy have an increased risk of disease exposure, which reinforces the need for chemoprophylactic measures, such as the use of rifampicin. OBJECTIVES: The objective of the review was to synthesize the best available evidence regarding the effectiveness of rifampicin chemoprophylaxis for contacts with patients with leprosy, and to synthesize the best available evidence on the experience and acceptability of rifampicin chemoprophylaxis as reported by the contacts and health professionals involved in the treatment of leprosy or Hansen's disease...
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29035911/ab-interno-gel-implant-for-the-treatment-of-glaucoma-patients-with-or-without-prior-glaucoma-surgery-one-year-results
#17
Fritz H Hengerer, Thomas Kohnen, Michael Mueller, Ina Conrad-Hengerer
PURPOSE: To evaluate IOP lowering effects and complication management of an ab interno gel implant for the treatment of patients refractory to anti-glaucoma medication or glaucoma surgery. METHODS: Retrospective analysis of the medical records of 242 consecutive eyes of 146 patients with uncontrolled intraocular pressure (IOP) despite maximum tolerated medical therapy or prior surgical intervention that underwent XEN45 implantation (as sole procedure or in combination with cataract surgery) between March 2014 and June 2015...
October 13, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29035574/a-6-month-open-label-extension-study-of-vortioxetine-in-pediatric-patients-with-depressive-or-anxiety-disorders
#18
Robert L Findling, Adelaide S Robb, Melissa P DelBello, Michael Huss, Nora K McNamara, Elias H Sarkis, Russell E Scheffer, Lis H Poulsen, Grace Chen, Ole M Lemming, Philippe Auby
OBJECTIVES: In this 6-month open-label extension (OLE) of NCT01491035 (a 14-day, open-label, pharmacokinetic/safety lead-in study), the long-term safety and tolerability of vortioxetine (5-20 mg/day) were investigated in children and adolescents with a DSM-IV-TR™ diagnosis of depressive or anxiety disorder in the United States or Germany. The study also was designed to provide data to inform dose selection and titration in future pediatric studies with vortioxetine. METHODS: Safety evaluations included spontaneously reported adverse events (AEs), the Columbia Suicide Severity Rating Scale (C-SSRS), and the Pediatric Adverse Events Rating Scale (PAERS; clinician administered)...
October 16, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29034350/function-preserving-surgery-for-gastric-cancer-current-status-and-future-perspectives
#19
REVIEW
Souya Nunobe, Naoki Hiki
The number of early gastric cancer (EGC) cases has been increasing because of improved diagnostic procedures including endoscopy and screening systems. Therefore, function-preserving gastrectomy (FPG) for EGC with the expectation of better quality of life (QOL) after surgery may be increasingly utilized, due to its association with low rate of lymph node metastasis and excellent survival and the possibility of employing less invasive procedures such as laparoscopic gastrectomy in combination. Pylorus-preserving gastrectomy (PPG) with curative intent lymph node dissection is a representative FPG that has been used in EGC, and its superiorities, indications, limitations, and survival benefits have already been reported in several retrospective studies...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29034281/systematic-review-of-the-safety-and-efficacy-of-contrast-injection-via-venous-catheters-for-contrast-enhanced-computed-tomography
#20
REVIEW
S B Buijs, M W Barentsz, M L J Smits, J W C Gratama, P E Spronk
OBJECTIVE: To examine the safety and efficacy of contrast injection through a central venous catheter (CVC) for contrast-enhanced computed tomography (CECT). METHODS: A systematic literature search was performed using PubMed. Studies were deemed eligible if they reported on the use of CVCs for contrast administration. Selected articles were assessed for their relevance and risk of bias. Articles with low relevance and high risk of bias or both were excluded. Data from included articles was extracted...
2017: European Journal of Radiology Open
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