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https://www.readbyqxmd.com/read/28812980/application-of-an-in-vitro-digestion-model-for-210po-bioaccessibility-assessment-in-seafood
#1
Carla Roselli, Donatella Desideri, Laura Feduzi, Lucia Ugolini, Maria Assunta Meli
This study aims to investigate the bioaccessibility of 210Po in seafood and the impact of food preparation on this radionuclide. Polonium bioaccessibility is the fraction of 210Po mobilized from food matrices into digestive extractants when applying an in vitro digestion model. The degree of bioaccessibility of 210Po in food has important implications for estimating ingestion doses from this radionuclide. The simulation of gastrointestinal digestion was divided into three stages through the use of synthetic saliva, gastric and bile-pancreas solutions...
August 16, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28811703/barrett-s-oesophagus-current-controversies
#2
REVIEW
Chidi Amadi, Piers Gatenby
Oesophageal adenocarcinoma is rapidly increasing in Western countries. This tumour frequently presents late in its course with metastatic disease and has a very poor prognosis. Barrett's oesophagus is an acquired condition whereby the native squamous mucosa of the lower oesophagus is replaced by columnar epithelium following prolonged gastro-oesophageal reflux and is the recognised precursor lesion for oesophageal adenocarcinoma. There are multiple national and society guidelines regarding screening, surveillance and management of Barrett's oesophagus, however all are limited regarding a clear evidence base for a well-demonstrated benefit and cost-effectiveness of surveillance, and robust risk stratification for patients to best use resources...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28807040/management-of-upper-gastrointestinal-bleeding-in-emergency-departments-from-bleeding-symptoms-to-diagnosis-a-prospective-multicenter-observational-study
#3
Pierre-Clément Thiebaud, Youri Yordanov, Jacques-Emmanuel Galimard, Pierre-Alexis Raynal, Sébastien Beaune, Laurent Jacquin, François-Xavier Ageron, Dominique Pateron
BACKGROUND: Upper gastrointestinal bleeding (UGB) is common in emergency departments (EDs) and can be caused by many eso-gastro-duodenal lesions. Most available epidemiological data and data on the management of UGB comes from specialized departments (intensive care units or gastroenterology departments), but little is known from the ED perspective. We aimed to determine the distribution of symptoms revealing UGB in EDs and the hemorrhagic lesions identified by endoscopy. We also describe the characteristics of patients consulting for UGB, UGB management in the ED and patients outcomes...
August 14, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28802231/phytochemical-properties-and-pharmacological-effects-of-quercus-ilex-l-aqueous-extract-on-gastrointestinal-physiological-parameters-in-vitro-and-in-vivo
#4
Kaïs Rtibi, Imen Hammami, Slimen Selmi, Dhekra Grami, Hichem Sebai, Mohamed Amri, Lamjed Marzouki
INTRODUCTION: Several research studies have reported on the pharmacological relevance of the medicinal plants used for treating various gastrointestinal disorders and controlling the dietary glucose uptake in the intestinal tract. METHODS: Male rats were used to investigate the pharmacological effects of green oak acorn aqueous extract (GOAE) on gastrointestinal physiological parameters in vivo and in vitro. In this respect, the gastro-intestinal motility and hypersecretion essays were evaluated using a simple test meal (10% charcoal in 5% gum arabic) and castor oil induced diarrhea...
August 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28801782/common-pediatric-medical-emergencies-in-office-practice
#5
Bharat Mehra, Suresh Gupta
General Practitioners frequently see children with medical conditions that may evolve into an emergency if not promptly attended to. The most common emergencies encountered in pediatric office practice are respiratory distress, dehydration, anaphylaxis, seizures and trauma. Assessment of children is sometimes difficult as the signs and symptoms might be subtle and not markedly expressed. Also, normal value of vital signs vary with age, thus their interpretation requires discrete knowledge of age appropriate values...
August 12, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28801746/laparoscopic-nissen-fundoplication-plus-mid-gastric-plication-for-treatment-of-obese-patients-with-gastroesophageal-reflux-disease
#6
Ahmed Talha, Mohammed Ibrahim
BACKGROUND: Gastroesophageal reflux disease (GERD) is commonly associated with obesity, and its surgical management is debatable. OBJECTIVE: The objective of this study was to prove the safety and feasibility of laparoscopic Nissen's fundoplication (LNF) combined with mid-gastric plication (MGP) for treatment of obese patients with GERD. METHODS: LNF combined with MGP was done for 18 patients. All interventions were performed under general anesthesia...
August 11, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28801248/clinical-value-of-ctdna-in-upper-gi-cancers-a-systematic-review-and-meta-analysis
#7
REVIEW
A Creemers, S Krausz, M Strijker, M J van der Wel, E C Soer, R J Reinten, M G Besselink, J W Wilmink, M J van de Vijver, C J M V Noesel, J Verheij, S L Meijer, F Dijk, M F Bijlsma, M G H van Oijen, H W M van Laarhoven
BACKGROUND: The recent expanding technical possibilities to detect tumor derived mutations in blood, so-called circulating tumor DNA (ctDNA), has rapidly increased the interest in liquid biopsies. This review and meta-analysis explores the clinical value of ctDNA in malignancies of the upper gastro-intestinal tract. METHODS: PubMed, Cochrane and Embase databases were searched to identify studies reporting the diagnostic, prognostic or predictive value of ctDNA in patients with esophageal, gastric and pancreatic cancer, until January 2017...
August 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28800409/cytotoxic-effects-of-the-proton-pump-inhibitor-omeprazole-on-the-non-target-marine-microalga-tetraselmis-suecica
#8
Marta Seoane, Marta Esperanza, Ángeles Cid
Omeprazole (OMP) is one of the most commonly used drugs for the treatment of gastro-intestinal disorders. Although it is daily consumed in high quantities and commonly detected in waters worldwide, relatively little is known about its ecotoxicity. The aim of this study was to evaluate the potential acute toxicity of increasing concentrations of OMP on the marine microalga Tetraselmis suecica analysing several cytotoxicity biomarkers by flow cytometry after 24h of exposure. Results showed that OMP caused a decrease in growth and autofluorescence, an increase in cellular volume and intracellular complexity, hyperpolarization of cytoplasmic and mitochondrial membranes and intracellular acidification...
August 2, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28799088/metazoan-parasites-from-odontocetes-off-new-zealand-new-records
#9
Kristina Lehnert, Haseeb Randhawa, Robert Poulin
Information about the parasite fauna of spectacled porpoises and cetaceans from New Zealand waters in general is scarce. This study takes advantage of material archived in collections of the Otago Museum in Dunedin and Massey University in Auckland, sampled from cetacean species found stranded along the New Zealand coastline between 2007 and 2014. Parasites from seven species of cetaceans (spectacled porpoise, Phocoena dioptrica (n = 2 individuals examined); pygmy sperm whale (n = 1); long-finned pilot whale, Globicephala melas (n = 1); Risso's dolphin, Grampus griseus (n = 1); short-beaked common dolphin, Delphinus delphis (n = 7); striped dolphin, Stenella coeruleoalba (n = 3) and dusky dolphin, Lagenorhynchus obscurus (n = 2)) from the respiratory and gastro-intestinal tract, cranial sinus, liver, urogenital and mammary tract, fascia and blubber were investigated...
August 10, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28797791/the-use-of-nemabiome-metabarcoding-to-explore-gastro-intestinal-nematode-species-diversity-and-anthelmintic-treatment-effectiveness-in-beef-calves
#10
Russell W Avramenko, Elizabeth M Redman, Roy Lewis, Murilo A Bichuette, Bruna M Palmeira, Thomas A Yazwinski, John S Gilleard
Next-generation deep amplicon sequencing, or metabarcoding, has revolutionized the study of microbial communities in humans, animals and the environment. However, such approaches have yet to be applied to parasitic helminth communities. We recently described the first example of such a method - nemabiome sequencing - based on deep-amplicon sequencing of internal transcribed spacer 2 (ITS-2) rDNA, and validated its ability to quantitatively assess the species composition of cattle gastro-intestinal nematode (GIN) communities...
August 7, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28793921/standardising-the-reporting-of-outcomes-in-gastric-cancer-surgery-trials-protocol-for-the-development-of-a-core-outcome-set-and-accompanying-outcome-measurement-instrument-set-the-gastros-study
#11
Bilal Alkhaffaf, Anne-Marie Glenny, Jane M Blazeby, Paula Williamson, Iain A Bruce
BACKGROUND: Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Whilst surgery is the mainstay of curative treatment, it is associated with significant risks. Surgical strategies for treating gastric cancer should be based on evidence from systematic reviews of well-designed randomised controlled trials. However, inconsistencies in the reporting of outcomes from these trials makes evidence synthesis unreliable. We present a protocol for an international consensus study to develop a standardised set of outcomes and measurement tools - a 'core outcome set' (COS) - to be used by all future trials examining therapeutic surgical interventions for gastric cancer...
August 9, 2017: Trials
https://www.readbyqxmd.com/read/28791329/clinical-impact-of-eus-treatment-of-walled-off-pancreatic-necrosis-with-dedicated-devices
#12
Ilaria Tarantino, Dario Ligresti, Fabio Tuzzolino, Luca Barresi, Gabriele Curcio, Antonino Granata, Mario Traina
BACKGROUND AND STUDY AIMS:  Walled-off pancreatic necrosis (WOPN) represents the major risk factor for sepsis-related multiple organ failure. Surgical debridement is an invasive approach associated with high rates of adverse events (AEs) and death. As an alternative, endoscopic ultrasound-guided cysto-gastro-anastomosis has emerged as an effective treatment for WOPNs. Recently a new dedicated-lumen apposing metal stent (LAMS) has been used with satisfactory results in treating peri-pancreatic fluid collections, including WOPNs...
August 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28783111/nutritional-guidelines-and-fermented-food-frameworks
#13
Victoria Bell, Jorge Ferrão, Tito Fernandes
This review examines different nutritional guidelines, some case studies, and provides insights and discrepancies, in the regulatory framework of Food Safety Management of some of the world's economies. There are thousands of fermented foods and beverages, although the intention was not to review them but check their traditional and cultural value, and if they are still lacking to be classed as a category on different national food guides. For understanding the inconsistencies in claims of concerning fermented foods among various regulatory systems, each legal system should be considered unique...
August 7, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28782675/prevalence-of-dyspepsia-in-individuals-with-gastro-esophageal-reflux-type-symptoms-in-the-community-a-systematic-review-and-meta-analysis
#14
Leonardo H Eusebi, Raguprakash Ratnakumaran, Franco Bazzoli, Alexander C Ford
BACKGROUND & AIMS: Dyspepsia and gastro-esophageal reflux are highly prevalent in the general population, but they are believed to be separate entities. We conducted a systematic review and meta-analysis to estimate the prevalence of dyspepsia in individuals with gastro-esophageal reflux symptoms (GERS), and to quantify overlap between the disorders. METHODS: We searched MEDLINE, EMBASE, and EMBASE Classic databases to identify population-based studies reporting the prevalence of dyspepsia and GERS in adults, defined using specific symptom-based criteria or based on answers to questionnaires...
August 3, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28776330/multidimensional-assessment-of-severe-asthma-a-systematic-review-and-meta-analysis
#15
REVIEW
Vanessa L Clark, Peter G Gibson, Grayson Genn, Sarah A Hiles, Ian D Pavord, Vanessa M McDonald
The management of severe asthma is complex. Multidimensional assessment (MDA) of specific traits has been proposed as an effective strategy to manage severe asthma, although it is supported by few prospective studies. We aimed to systematically review the literature published on MDA in severe asthma, to identify the traits included in MDA and to determine the effect of MDA on asthma-related outcomes. We identified 26 studies and classified these based on study type (cohort/cross-sectional studies; experimental/outcome studies; and severe asthma disease registries)...
August 3, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28774840/multi-kinetics-and-site-specific-release-of-gabapentin-and-flurbiprofen-from-oral-fixed-dose-combination-in-vitro-release-and-in-vivo-food-effect
#16
Fabio Sonvico, Chiara Conti, Gaia Colombo, Francesca Buttini, Paolo Colombo, Ruggero Bettini, Marco Barchielli, Barbara Leoni, Luca Loprete, Alessandra Rossi
In this work, a fixed-dose combination of gabapentin and flurbiprofen formulated as multilayer tablets has been designed, developed and studied in vitro and in vivo. The aim was to construct a single dosage form of the two drugs, able to perform a therapeutic program involving three release kinetics and two delivery sites, i.e., immediate release of gabapentin, intra-gastric prolonged release of gabapentin and intestinal (delayed) release of flurbiprofen. An oblong three-layer tablet was manufactured having as top layer a floating hydrophilic polymeric matrix for gastric release of gabapentin, as middle layer a disintegrating formulation for immediate release of a gabapentin loading dose and as bottom layer, an uncoated hydrophilic polymeric matrix, swellable but insoluble in gastric fluids, for delayed and prolonged release of flurbiprofen in intestinal environment...
July 31, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28770420/efficacy-and-tolerability-of-delayed-release-dimethyl-fumarate-in-black-hispanic-and-asian-patients-with-relapsing-remitting-multiple-sclerosis-post-hoc-integrated-analysis-of-define-and-confirm
#17
Robert J Fox, Ralf Gold, J Theodore Phillips, Macaulay Okwuokenye, Annie Zhang, Jing L Marantz
INTRODUCTION: Clinical course and treatment response may vary according to race/ethnicity in multiple sclerosis (MS) patients. Delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) demonstrated significant efficacy and a favorable benefit-risk profile in relapsing-remitting MS (RRMS) patients in the 2-year phase III DEFINE/CONFIRM studies. METHODS: In this post hoc analysis of integrated data from DEFINE/CONFIRM, we assessed clinical efficacy and safety/tolerability in black, Hispanic, and Asian patients treated with DMF 240 mg twice daily (approved dosage) or placebo...
August 2, 2017: Neurology and Therapy
https://www.readbyqxmd.com/read/28766283/management-of-aorto-esophageal-fistula-secondary-after-thoracic-endovascular-aortic-repair-a-review-of-literature
#18
REVIEW
Kaname Uno, Tomoyuki Koike, Seiichi Takahashi, Daisuke Komazawa, Tooru Shimosegawa
Aorto-esophageal fistula (AEF) is a rare and lethal entity, and the difficulty of making diagnosis of AEF is well-known. As promising results in the short-term effectiveness of thoracic endovascular aortic repair (TEVAR) promote its usage, the occurrence of AEF after TEVAR (post-TEVAR AEF) increases as one of the major complications. Therefore, we provide a review concerning the management strategy of post-TEVAR AEF. Although its representative symptom was reported as the triad of mid-thoracic pain and sentinel hematemesis followed by massive hematemesis, the symptom-free interval between sentinel hemorrhage and massive exsanguination is unpredictable...
August 1, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28765989/eco-health-linkages-assessing-the-role-of-ecosystem-goods-and-services-on-human-health-using-causal-criteria-analysis
#19
REVIEW
Rebeca de Jesus Crespo, Richard Fulford
OBJECTIVES: In the last decade, we saw an upsurge of studies evaluating the role of ecosystem goods and services (EGS) on human health (Eco-Health). Most of this work consists of observational research of intermediate processes and few address the full pathways from ecosystem to EGS to human health, limiting our ability to assess causality. METHODS: We conducted a causal criteria analysis of Eco-Health literature using Eco-Evidence, a software tool that helps evaluate evidence of cause-effect relationships...
August 1, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28764205/prevalence-and-patterns-of-multimorbidity-among-human-immunodeficiency-virus-positive-people-in-odisha-india-an-exploratory-study
#20
Sanghamitra Pati, Shreeporna Bhattacharya, Subhashisa Swain
INTRODUCTION: Improved and efficient Anti-Retroviral Therapy (ART) has turned HIV positive into a chronic disorder. The increase in life expectancy and quality of life comes with an increased risk of multimorbidity from the traditional risk factors. AIM: To explore the prevalence of multimorbidity among People Living with HIV (PLHIV). MATERIALS AND METHODS: An exploratory cross-sectional study was carried out in an ART center of Odisha, India, from November 2013 to December 2013...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
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