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https://www.readbyqxmd.com/read/28224561/radical-resection-of-a-primary-unresectable-duodenal-cancer-after-chemotherapy-using-s-1-and-cisplatin-report-of-a-case
#1
Masaru Kanehira, Yasuro Futagawa, Kenei Furukawa, Hiroaki Shiba, Tadashi Uwagawa, Katsuhiko Yanaga
BACKGROUND: Therapeutic outcomes and prognosis of primary unresectable duodenal cancer remains unsatisfactory, because effective chemotherapy is not established. CASE PRESENTATION: A 71-year-old male diagnosed with unresectable duodenal carcinoma with distant lymph node metastases was judged inoperable (cT3N2M1 cStage in UICC(7th)). Duodenal obstruction developed due to tumor growth, and the patient underwent laparoscopic gastro-jejunostomy and then combined chemotherapy using S-1 and cisplatin...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28223922/gut-microbiota-a-potential-regulator-of-neurodevelopment
#2
REVIEW
Paola Tognini
During childhood, our brain is exposed to a variety of environmental inputs that can sculpt synaptic connections and neuronal circuits, with subsequent influence on behavior and learning processes. Critical periods of neurodevelopment are windows of opportunity in which the neuronal circuits are extremely plastic and can be easily subjected to remodeling in response to experience. However, the brain is also more susceptible to aberrant stimuli that might lead to altered developmental trajectories. Intriguingly, postnatal brain development is paralleled by the maturation of the gut microbiota: the ecosystem of symbionts populating our gastro-intestinal tract...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28223233/unravelling-the-pharmacologic-opportunities-and-future-directions-for-targeted-therapies-in-gastro-intestinal-cancers-part-1-gi-carcinomas
#3
REVIEW
Cindy Neuzillet, Benoît Rousseau, Hemant Kocher, Philippe Bourget, Christophe Tournigand
Until the 1990s, cytotoxic chemotherapy has been the cornerstone of medical therapy for gastrointestinal (GI) cancers. Better understanding of the molecular biology of cancer cell has led to the therapeutic revolution of targeted therapies, i.e. monoclonal antibodies or small molecule inhibitors directed against proteins that are specifically overexpressed or mutated in cancer cells. These agents being more specific to cancer cells were expected to be less toxic than cytotoxic agents. Targeted agents have provided clinical benefit in many GI cancer types...
February 13, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28223101/non-invasive-evaluation-of-portal-hypertension-using-ultrasound-elastography
#4
REVIEW
Annalisa Berzigotti
Portal hypertension (PH) leads to serious complications such as bleeding from gastro-esophageal varices, ascites and porto-systemic encephalopathy in patients with chronic liver disease (CLD). Since the gold-standard methods for assessing PH and its complications (measurement of hepatic venous pressure gradient, HVPG; endoscopy), are invasive expensive and not available at all centers, non-invasive methods have been increasingly investigated in the last 20 years. The present review focuses on the role of ultrasound elastography, a novel group of non-invasive techniques able to measure stiffness in target organs, to identify the presence, severity and risk of complications of PH...
February 13, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28221719/influence-of-bouncing-and-assisted-autogenic-drainage-on-acid-gastro-oesophageal-reflux-in-infants
#5
Filip Van Ginderdeuren, Yvan Vandenplas, Michel Deneyer, Sylvie Vanlaethem, Ronald Buyl, Eric Kerckhofs
OBJECTIVES: To determine the influence of modern airway clearance techniques using assisted autogenic drainage (AAD), whether or not combined with bouncing, on acid gastro-oesophageal reflux (GOR) in infants <1 year. METHODS: In this controlled trial with intra-subject design infants were studied using oesophageal pH monitoring over 24 h, during which they received one 15 min session of bouncing, AAD or bouncing combined with AAD (BAAD). The number of reflux episodes (RE) and the refluxindex (RI) were the outcome measures...
February 21, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28215168/contributions-of-the-interaction-between-dietary-protein-and-gut-microbiota-to-intestinal-health
#6
Ning Ma, Yanan Tian, Yi Wu, Xi Ma
There is growing recognition that composition and metabolic activity of the gut microbiota can be modulated by the dietary proteins which in turn impact health. The amino acid composition and digestibility of proteins, which are influenced by its source and amount of intake, play a pivotal role in determining the microbiota. Reciprocally, it appears that the gut microbiota is also able to affect protein metabolism which give rise to the view that function between the microbiota and protein can proceed in both directions...
February 16, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28215067/epidemiology-and-natural-history-of-gastro-esophageal-reflux-disease
#7
Edoardo Savarino, Elisa Marabotto, Giorgia Bodini, Gaia Pellegatta, Claudia Coppo, Elisa Giambruno, Matteo Brunacci, Patrizia Zentilin, Vincenzo Savarino
Gastroesophageal reflux disease (GERD) is highly prevalent in Western countries, particularly when considering its most classic symptom, that is heartburn. This symptom is very frequent in the community and ranges from 10% to more than 30%, according to the various population-based studies. This disease is much more represented in Europe and US than in Asiatic countries. It has been shown that GERD prevalence increases in parallel with the remarkable growth of obesity, as this condition is able to favor all the pathogenetic mechanisms leading to it...
February 17, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28214685/role-of-laxative-and-antioxidant-properties-of-malva-sylvestris-leaves-in-constipation-treatment
#8
Mohamed-Amine Jabri, Dalanda Wannes, Najla Hajji, Mohsen Sakly, Lamjed Marzouki, Hichem Sebai
INTRODUCTION: Mallaw (Malva sylvestris L.) is a medicinal plant who is traditionally being used as an antiulcer, laxative and anti-hemorrhoid, besides of its culinary use as a food in Tunisian cuisine. The present study was carried out to evaluate the protective effect of Malva sylvestris aqueous extract (MSAE) on constipation- induced by loperamide in male Wistar rats. METHODS: Rats were divided into six groups of six animals each: Control, Loperamide (LOP), LOP+ yohimbine (2mg/kg b...
February 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28214353/association-of-gastro-oesophageal-reflux-and-chronic-rhinosinusitis-systematic-review-and-meta-analysis
#9
S R Leason, H P Barham, G Oakley, J Rimmer, J M DelGaudio, J M Christensen, R Sacks, R J Harvey
INTRODUCTION: Gastro-oesophageal reflux disease (GORD) has been implicated in the development of chronic rhinosinusitis (CRS). The association of GORD with CRS is systematically assessed from the medical literature. METHODOLOGY: Embase and MEDLINE were searched using a comprehensive strategy limited to English language and Human subjects. Any study with original data on the experimental, diagnostic, treatment or prognostic association of CRS with GORD was included...
February 18, 2017: Rhinology
https://www.readbyqxmd.com/read/28214352/gastro-oesophageal-reflux-in-patients-with-chronic-rhino-sinusitis-investigated-with-multichannel-impedance-ph-monitoring
#10
(no author information available yet)
INTRODUCTION: The pathophysiology of chronic rhinosinusitis (CRS) is unclear. It has been discussed for decades whether gastro-oesophageal reflux (GOR) may be a contributing factor for some patients. The aim of the present study was to evaluate the level of GOR in an unselected group of patients with CRS using multichannel impedance-pH monitoring. METHODS: Consecutive patients with CRS diagnosed using the EPOS2012 criteria, completed questionnaires on GOR symptoms and were offered 24-h multichannel intraluminal impedance (MII)-pH monitoring...
February 18, 2017: Rhinology
https://www.readbyqxmd.com/read/28213760/endocrine-regulation-of-fueling-by-hyperphagia-in-migratory-birds
#11
Cas Eikenaar
To support migratory endurance flight, birds accumulate large amounts of fat by hyperphagia (fueling). Whereas the factors influencing migrants' motivation to fuel are well described, the physiological mechanism regulating fueling is largely unknown. Hormones are likely involved and arguably the best studied with respect to food intake and fueling is corticosterone. Corticosterone has a permissive effect, as blocking the hormone's actions prohibits efficient fueling. There are no indications, though that corticosterone stimulates fueling, and some studies even observed negative correlations between corticosterone level and food intake and speed of fueling...
February 17, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/28211278/endoscopic-removal-of-multiple-sharp-gastro-duodenal-foreign-bodies
#12
Samuel Costa, Raquel Gonçalves, Carla Rolanda
A 45 years old female,with bipolar disorder,was brought to the Emergency Department with abdominal pain. The patient was hemodynamically stable,with no signs of respiratory distress. On abdominal examination she had pain in the upper quadrants,without peritoneal irritation. The successful endoscopic removal decreases if delayed approach, beyond 12 h, and sharp objects. Moreover in case of sharp objects, even if already into the stomach or duodenum, they should be retrieved endoscopically if it can be accomplished safely, because the risk of a complication during its natural exteriorization is as high as 35%...
February 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28209107/gastro-intestinal-manifestations-in-cystic-fibrosis-patients
#13
REVIEW
S Van Biervliet, C de Clercq, D Declercq, E Van Braeckel, S Van Daele, F De Baets, D De Looze
Cystic fibrosis (CF) is a life-limiting disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). This defective chloride channel, present in different organ systems such as respiratory system, gastrointestinal tract, reproductive system and sweat glands, disturbs the ion and water transport over the membranes leading to the well known CF symptoms. CF has outgrown paediatric care, as half of CF patients are currently adults. The CF gastrointestinal tract has its own particularities...
September 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/28205007/long-term-evaluation-of-biliary-reflux-after-experimental-one-anastomosis-gastric-bypass-in-rats
#14
Matthieu Bruzzi, Henri Duboc, Caroline Gronnier, Dominique Rainteau, Anne Couvelard, Maude Le Gall, André Bado, Jean-Marc Chevallier
BACKGROUND: Controversy remains regarding biliary reflux after one-anastomosis gastric bypass (OAGB). The aim of this "pilot" study was to analyze biliary reflux and its potential long-term consequences on esogastric mucosae in OAGB-operated rats. METHODS: Diet-induced obese rats were subjected to OAGB (n = 10) or sham (n = 4) surgery and followed up for 16 weeks. Evolution of weight and glucose tolerance was analyzed. Bile acid concentration measurement, histological and qRT-PCR analysis were performed in the esogastric segments...
February 15, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28203684/crushed-sublingual-versus-oral-ticagrelor-administration-strategies-in-patients-with-unstable-angina-a-pharmacokinetic-pharmacodynamic-study
#15
Piotr Niezgoda, Joanna Sikora, Malwina Barańska, Adam Sikora, Katarzyna Buszko, Emilia Siemińska, Michał Piotr Marszałł, Jolanta M Siller-Matula, Bernd Jilma, Dimitrios Alexopoulos, Tomasz Fabiszak, Jacek Kubica
Oral administration of crushed ticagrelor tablets turned out to be an efficacious method that improves its pharmacokinetics and pharmacodynamics. This strategy, however, is unlikely to eliminate the drug-drug interaction in patients receiving intravenous morphine, as the impairment of the P2Y12 inhibitor absorption related to decreased propulsive motility of the gastro-intestinal tract is the most likely mechanism of interaction. Thus, we designed a pharmacokinetic and pharmacodynamic study setting the feasibility of platelet inhibition with a loading dose of ticagrelor given as crushed tablets sublingually compared with two other ticagrelor loading dose administration strategies: integral tablet given orally and crushed tablet given orally in patients with unstable angina...
February 16, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28201966/synthesis-and-biological-evaluation-of-mutual-prodrugs-of-carboxylic-group-containing-some-non-steroidal-anti-inflammatory-drugs-and-propyphenazone
#16
Sucheta Ohlan, Meenu Paliwal, Ruchita Ruchita, Shilpa Jain, Monika Monika, Himanshu Himanshu
Non-steroidal anti-inflammatory drugs (NSAIDs); ketorolac (KA), niflumic acid (NA), tolfenamic acid (TA) were conjugated with propyphenazone derivative 3-Hydroxymethyl propyphenazone (HMP) by direct coupling and by using spacer technique with the objective of obtaining gastro-sparing NSAIDs prodrugs devoid of ulcerogenic side effects. Mutual prodrugs were synthesized and their structures were confirmed and characterized using IR, 1H NMR, 13C NMR, mass spectroscopy and their purity was established by elemental analysis...
February 13, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28198489/negative-effects-of-divalent-mineral-cations-on-the-bioaccessibility-of-carotenoids-from-plant-food-matrices-and-related-physical-properties-of-gastro-intestinal-fluids
#17
Joana Corte-Real, Marie Bertucci, Christos Soukoulis, Charles Desmarchelier, Patrick Borel, Elke Richling, Lucien Hoffmann, Torsten Bohn
Carotenoid intake and tissue levels have been frequently associated with reduced risk of chronic diseases. However, their bioavailability is low and influenced by many dietary related parameters. Divalent mineral cations have been suggested to interfere with carotenoid digestion and to hamper micellarization, a prerequisite for their uptake, via complexation of bile salts and precipitation of fatty acids. In the present investigation, we have evaluated the effects of increasing concentrations of magnesium (0-300 mg L(-1)), calcium (0-1500 mg L(-1)), zinc (0-200 mg L(-1)), and sodium (0-1500 mg L(-1); control monovalent cation), on carotenoid bioaccessibility from frequently consumed food items rich in carotenoids (tomato juice, carrot juice, apricot nectar, spinach and field salad), following simulated gastro-intestinal digestion...
February 15, 2017: Food & Function
https://www.readbyqxmd.com/read/28197046/outcome-of-noncardiac-surgical-patients-admitted-to-a-multidisciplinary-intensive-care-unit
#18
Pradeep Kumar, M K Renuka, M S Kalaiselvan, A S Arunkumar
CONTEXT: Surgical procedures carry significant morbidity and mortality depending on the type of surgery and patients. There is a dearth of evidence from India on the outcome of surgical patients admitted to an Intensive Care Unit (ICU). AIMS: We aimed to describe the incidence and risk factors of postoperative complications and mortality in noncardiac surgical patients admitted to the ICU. SETTINGS AND DESIGN: This was a prospective observational study on all perioperative patients admitted to a multidisciplinary ICU for 18 months...
January 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28193167/helicobacter-pylori-prevalence-and-clinical-significance-in-patients-with-quiescent-crohn-s-disease
#19
Adi Lahat, Uri Kopylov, Sandra Neuman, Nina Levhar, Doron Yablecovitch, Benjamin Avidan, Batia Weiss, Shomron Ben-Horin, Rami Eliakim
BACKGROUND: Helicobacter pylori (HP) infection is present in about 50% of the global population, and is associated with chronic gastritis, peptic disease and gastric malignancies. HP prevalence in Crohn's disease (CD) patients was shown to be low compared to the general population, and its influence on disease activity is yet to be determined. Our aims were to determine the prevalence of HP in a selected group of CD patients with quiescent disease, and to assess the influence of its eradication on disease activity and endoscopic and laboratory activity measures...
February 13, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28192466/descriptive-study-of-plant-resources-in-the-context-of-the-ethnomedicinal-relevance-of-indigenous-flora-a-case-study-from-toli-peer-national-park-azad-jammu-and-kashmir-pakistan
#20
Muhammad Shoaib Amjad, Mirza Faisal Qaeem, Israr Ahmad, Sami Ullah Khan, Sunbal Khalil Chaudhari, Nafeesa Zahid Malik, Humaira Shaheen, Arshad Mehmood Khan
BACKGROUND: This paper presents the first quantitative ethnobotanical study of the flora in Toli Peer National Park of Azad Jammu and Kashmir, Pakistan. Being a remote area, there is a strong dependence by local people on ethnobotanical practices. Thus, we attempted to record the folk uses of the native plants of the area with a view to acknowledging and documenting the ethnobotanical knowledge. The aims of the study were to compile an inventory of the medicinal plants in the study area and to record the methods by which herbal drugs were prepared and administered...
2017: PloS One
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