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https://www.readbyqxmd.com/read/28526986/implementation-of-quality-by-design-for-formulation-of-rebamipide-gastro-retentive-tablet
#1
Jung-Myung Ha, Jeong-Woong Seo, Su-Hyeon Kim, Ju-Young Kim, Chun-Woong Park, Yun-Seok Rhee, Eun-Seok Park
The purpose of the present study was to develop a rebamipide (RBM) gastro-retentive (GR) tablet by implementing quality by design (QbD). RBM GR tablets were prepared using a sublimation method. Quality target product profile (QTPP) and critical quality attributes (CQAs) of the RBM GR tablets were defined according to the preliminary studies. Factors affecting the CQAs were prioritized using failure mode and effects analysis (FMEA). Design space and optimum formulation were established through a mixture design...
May 19, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28525933/one-step-endoscopic-ultrasound-directed-gastro-gastrostomy-ercp-for-treatment-of-bile-leak
#2
Ming-Ming Xu, Carlos Carames, Aleksey Novikov, Monica Saumoy, Che Afaneh, Michel Kahaleh, Reem Z Sharaiha
No abstract text is available yet for this article.
May 19, 2017: Endoscopy
https://www.readbyqxmd.com/read/28521673/simple-strategy-to-protect-lactase-activity-in-solid-formulation
#3
Aline Gravinez Perissinato, André Luis Morais Ruela, Gislaine Ribeiro Pereira, Jerusa Simone Garcia, Marcello Garcia Trevisan
Lactose intolerance is characterized by the absence of the enzyme lactase (beta-galactosidase) and affects two thirds of the world adult population. Our aim was to evaluate a lactase gastro formulation to ensure increased activity in the action site of the enzyme (lumen of the small intestine). Simultaneously, we also evaluated the commercial product stability and enzyme activity. When carrying out dissolution test in commercial product it is noted that the existing formulation is not able to protect the enzyme from degrading action of gastric environment (a loss of 86...
May 18, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28516204/a-novel-dynamic-statistical-model-for-predicting-patient-satisfaction-with-fundoplication-based-on-pre-operative-symptom-patterns
#4
B L Woodham, R Meng, R H Roberts
BACKGROUND: Fundoplication provides excellent control of gastro-oesophageal reflux disease (GORD), but there remain a number of unsatisfied patients who have proven difficult to identify pre-operatively. We hypothesised that pre-operative symptom patterns can predict of the risk of post-operative dissatisfaction. METHODS: Pre-operative symptoms and post-operative satisfaction were measured using standardised questionnaires along with routine investigations. These data were used to calculate our novel pre-operative risk of dissatisfaction (PROD) score...
May 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28512025/synthesis-of-methanesulphonamido-benzimidazole-derivatives-as-gastro-sparing-antiinflammatory-agents-with-antioxidant-effect
#5
Ratika Sharma, Alka Bali, Bhim Bahadur Chaudhari
A series of 5-methanesulphonamido benzimidazole derivatives were designed by combining the structural features of clinically useful anti-inflammatory drugs (nimesulide and rofecoxib) and antiulcer drugs (lansoprazole, omeprazole, etc.) based on physicochemical and 3D similarity studies. The compounds were evaluated for their anti-inflammatory activity in carrageenan induced rat paw edema model taking rofecoxib and indomethacin as standard drugs. In vitro antioxidant activity of the compounds was assessed by potassium ferricyanide reducing power (PFRAP) assay...
May 6, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28506663/cough-associated-with-gastro-oesophageal-reflux-disease-gord-japanese-experience
#6
REVIEW
Akio Niimi
Differences in the aetiology as well as patient background of chronic cough have been recognised among US, UK, and Japan. One of the marked differences has been the prevalence of gastro-oesophageal reflux disease (GORD), which has been one of the top three causes in Western countries. It was indeed uncommon or rare in Japan, but, with the increasing prevalence of GOR itself, chronic cough associated with GORD seems to have become more common. In this article, cough associated with GORD will be reviewed based on literature and our Japanese experience...
May 12, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28503960/management-of-severe-complications-in-beh%C3%A3-et-s-disease-with-anti-tnf%C3%AE-inhibitors
#7
A C Desbois, H Vallet, F Domont, C Comarmond, P Cacoub, D Saadoun
The efficacy of anti-TNFα agents has been recently evaluated in many studies in Behçet's disease (BD), particularly in ocular and life-threatening manifestations such as neurological and vascular disease. Areas covered: The following article aims to summarize the currently available efficacy and safety data of anti-TNFα agents in BD. Expert opinion: Most studies have shown dramatic and rapid efficacy with anti-TNFα agents on the main BD-associated issues including posterior uveitis, gastro-intestinal and neurological complications as well as major vessel disease...
May 15, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28503097/asthma-management-among-allergists-in-italy-results-from-a-survey
#8
M S Magnoni, M Caminati, G W Canonica, F Arpinelli, A Rizzi, G Senna
BACKGROUND: In Europe more than 50% of asthmatic treated patients have not well-controlled asthma. Asthma affects about 2.5 million of patients in Italy. AIMS AND OBJECTIVES: The present survey aims at investigating how Italian allergists approach asthmatic patients, in order to highlight pitfalls and unmet needs concerning real-life asthma management. METHODS: An anonymous 16 item web questionnaire was available (April-October 2015) to all allergists who visited the web site of SIAAIC (Società Italiana di Allergologia, Asma Immunologia Clinica)...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/28502417/analysis-of-bronchial-biopsies-in-chronic-cough
#9
Patricia Macedo, Qingling Zhang, Junpei Saito, Zhike Liang, Lorrette Ffolkes, Andrew G Nicholson, Kian Fan Chung
BACKGROUND: Chronic cough is commonly associated with asthma, gastro-oesophageal reflux disease and postnasal drip, but in a significant proportion, no associated cause can be found. We determined whether examination of bronchial biopsies would be useful in determining the cause associated with chronic cough. METHODS: 100 consecutive patients referred to a specialist cough clinic underwent a systematic assessment including a fiberoptic bronchoscopy for bronchial biopsies...
June 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28501762/poorly-differentiated-gastro-entero-pancreatic-neuroendocrine-carcinomas-are-they-really-heterogeneous-insights-from-the-ffcd-gte-national-cohort
#10
T Walter, D Tougeron, E Baudin, K Le Malicot, T Lecomte, D Malka, O Hentic, S Manfredi, I Bonnet, R Guimbaud, R Coriat, C Lepère, C Desauw, A Thirot-Bidault, L Dahan, G Roquin, T Aparicio, J-L Legoux, C Lombard-Bohas, J-Y Scoazec, C Lepage, G Cadiot
BACKGROUND: Diagnosis and management of poorly differentiated gastro-entero-pancreatic (GEP) neuroendocrine carcinomas (NECs) remain challenging. Recent studies suggest prognostic heterogeneity. We designed within the French Group of Endocrine Tumours a prospective cohort to gain insight in the prognostic stratification and treatment of GEP-NEC. PATIENTS AND METHODS: All patients with a diagnosis of GEP-NEC between 1st January 2010 and 31st December 2013 could be included in this national cohort...
May 11, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28500039/selected-probiotic-lactobacilli-have-the-capacity-to-hydrolyze-gluten-peptides-during-simulated-gastro-intestinal-digestion
#11
Ruggiero Francavilla, Maria De Angelis, Carlo Giuseppe Rizzello, Noemi Cavallo, Fabio Dal Bello, Marco Gobbetti
The aim of this study was to demonstrate the capacity of probiotic lactobacilli to hydrolyze immunogenic gluten peptides. Eighteen commercial strains of probiotic lactobacilli with highly variable peptidase activity (i.e., aminopeptidase N, iminopeptidase, prolyl endopeptidyl peptidase, tripeptidase, prolidase, prolinase and dipeptidase), including towards Pro-rich peptides, were tested in this study. Ten probiotic strains were selected based on their specific enzyme activity. When pooled, these ten strains provide the peptidase portfolio that is required to completely degrade the immunogenic gluten peptides involved in celiac disease (CD)...
May 12, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28499200/interactions-of-mussel-inspired-polymeric-nanoparticles-with-gastric-mucin-implications-for-gastro-retentive-drug-delivery
#12
Suhair Sunoqrot, Lina Hasan, Aya Alsadi, Rania Hamed, Ola Tarawneh
Mussel-inspired polydopamine (pD) coatings have several unique characteristics such as durability, versatility, and robustness. In this study, we have designed pD-coated nanoparticles (NPs) of methoxy polyethylene glycol-b-poly(ε-caprolactone) (mPEG-PCL@pD) as prospective nanoscale mucoadhesive platforms for gastro-retentive drug delivery. Successful pD coating on the NPs was confirmed by Transmission Electron Microscopy and X-ray Photoelectron Spectroscopy. Mucoadhesion of pD-coated NPs was investigated in vitro using commercially available mucin under stomach lumen-mimetic conditions...
May 3, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28495584/food-effects-in-paediatric-medicines-development-for-products-co-administered-with-food
#13
Hannah Batchelor, Ann Marie Kaukonen, Sandra Klein, Barbara Davit, Rob Ju, Robert Ternik, Tycho Heimbach, Wen Lin, Jian Wang, David Storey
A small amount of food is commonly used to aid administration of medicines to children to improve palatability and/or swallowability. However the impact of this co-administered food on the absorption and subsequent pharmacokinetic profile of the drug is unknown. Existing information on food effects is limited to standard protocols used to evaluate the impact of a high fat meal in an adult population using the adult medication. In the absence of a substantial body of data, there are no specific guidelines available during development of paediatric products relating to low volumes of potentially low calorie food...
May 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28487082/esophageal-chemical-clearance-and-baseline-impedance-values-in-patients-with-chronic-autoimmune-atrophic-gastritis-and-gastro-esophageal-reflux-disease
#14
Andrea Tenca, Nicola de Bortoli, Aurelio Mauro, Marzio Frazzoni, Edoardo Savarino, Sara Massironi, Salvatore Russo, Lorenzo Bertani, Santino Marchi, Roberto Penagini
BACKGROUND: The factors influencing new markers of gastro-esophageal reflux disease detected by impedance-pH monitoring - mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index - need to be evaluated. AIM: To compare endoscopy-negative heartburn with chronic autoimmune atrophic gastritis (CAAG). MATERIALS AND METHODS: 24 patients with CAAG, 25 with non-erosive reflux disease (NERD) and 25 with functional heartburn (FH) were included...
April 13, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28476381/unusual-asymptomatic-presentation-of-bladder-cancer-metastatic-to-the-penis
#15
Francesca Giunchi, Francesco Vasuri, Vagnoni Valerio, Ilaria Montagnani, Federico Nelli, Michelangelo Fiorentino, Maria Rosaria Raspollini
Penile metastasis is an extremely rare event and mainly originate from primary pelvic tumor sites such us urinary bladder, gastro-intestinal tract and prostate and more rarely from respiratory system, bone tumors and melanoma. Here we describe the unusual presentation of two bladder urothelial cancer metastatic to the penis with no relevant clinical symptoms. Namely, a 69 years-old man with a warthy lesions of the foreskin and the glans misunderstood for a condylomata that at histological and immunohistochemical analysis showed a bladder urothelial carcinoma; and a 71 years-old man with reddish skin lesion of the glans, a previous history of bladder and urethral carcinoma and histological pagetoid spread of urothelial cancer to the glans...
December 2, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28475554/sustained-viral-suppression-in-hiv-infected-children-on-once-daily-lopinavir-ritonavir-in-clinical-practice
#16
Ivar P E Gondrie, Diane E T Bastiaans, Pieter L A Fraaij, Gertjan J A Driessen, Linda C Van Der Knaap, Eline G Visser, Petronette Van Jaarsveld, Ronald de Groot, Nico G Hartwig, David M Burger, Annemarie M C Van Rossum
BACKGROUND: The use of lopinavir/ritonavir once-daily (LPV/r QD) has not been approved for children. Good short-term clinical, virological and immunological outcomes have been observed in children on LPV/r QD. METHODS: We evaluated the long-term effectiveness of a LPV/r QD containing regimen in HIV-1 infected children in clinical practice. Selected children (aged 0-18 years) with an undetectable HIV-1 RNA viral load (<50 copies/mL) for at least 6 months on a twice-daily (BID) LPV/r-containing regimen switched to LPV/r QD...
May 4, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28475216/ige-sensitization-to-anisakis-pegreffii-in-italy-comparison-of-two-methods-for-the-diagnosis-of-allergic-anisakiasis
#17
S Mattiucci, A Colantoni, B Crisafi, F Mori-Ubaldini, L Caponi, P Fazii, G Nascetti, F Bruschi
IgE sensitization to Anisakis pegreffii in Italian subjects suffering from gastro-allergic anisakiasis (GAA) (N= 5), or showing chronic urticaria (CU+) after fish consumption (N= 100), was investigated. A control group (N= 5) was also included. IgE response was analyzed by immunoblotting (WB) assay, using both excretory/secretory products (ESPs) and crude extract (CE) of A. pegreffii larvae. The results were compared with those achieved by the conventional immunological method for Anisakis allergy (i.e. immunoCAP)...
May 5, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28474408/efficacy-of-sofosbuvir-and-ledipasvir-in-an-hcv-gastro-resected-patient
#18
C Taibi, M Tempestilli, A D'Avolio, A R Garbuglia, A De Nicolò, M Montalbano, G D'Offizi
WHAT IS KNOWN AND OBJECTIVE: The second-generation direct-acting antivirals represented the first major turning point for the eradication of HCV infection in almost all settings of patients. However, no data were available on use in gastro-resected patients. CASE DESCRIPTION: We report on a gastrectomized patient with chronic hepatitis C infection. She was treated with sofosbuvir and ledipasvir (SOF/LDV) for 12 weeks, with measurement of blood levels of the drugs...
May 4, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28471419/mitochondrial-deficiencies-in-the-predisposition-to-paraganglioma
#19
REVIEW
Charlotte Lussey-Lepoutre, Alexandre Buffet, Anne-Paule Gimenez-Roqueplo, Judith Favier
Paragangliomas and pheochromocytomas are rare neuroendocrine tumours with a very strong genetic component. It is estimated that around 40% of all cases are caused by a germline mutation in one of the 13 predisposing genes identified so far. Half of these inherited cases are intriguingly caused by mutations in genes encoding tricarboxylic acid enzymes, namely SDHA, SDHB, SDHC, SDHD, and SDHAF2 genes, encoding succinate dehydrogenase and its assembly protein, FH encoding fumarate hydratase, and MDH2 encoding malate dehydrogenase...
May 4, 2017: Metabolites
https://www.readbyqxmd.com/read/28470972/oral-calorie-supplements-for-cystic-fibrosis
#20
REVIEW
Rosalind L Smyth, Oli Rayner
BACKGROUND: Poor nutrition occurs frequently in people with cystic fibrosis and is associated with other adverse outcomes. Oral calorie supplements are used to increase total daily calorie intake and improve weight gain. However, they are expensive and there are concerns they may reduce the amount of food eaten and not improve overall energy intake. This is an update of a previously published review. OBJECTIVES: To establish whether in people with cystic fibrosis, oral calorie supplements: increase daily calorie intake; and improve overall nutritional intake, nutritional indices, lung function, survival and quality of life...
May 4, 2017: Cochrane Database of Systematic Reviews
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