keyword
https://read.qxmd.com/read/38537225/a-randomized-noninferiority-trial-to-compare-enteral-to-parenteral-phosphate-replacement-on-biochemistry-waste-and-environmental-impact-and-healthcare-cost-in-critically-ill-patients-with-mild-to-moderate-hypophosphatemia
#1
JOURNAL ARTICLE
Chinh D Nguyen, Haustine P Panganiban, Timothy Fazio, Amalia Karahalios, Melissa Akravs, Christopher M MacIsaac, Thomas Rechnitzer, Lucy Arno, An Tran-Duy, Scott McAlister, Yasmine Ali Abdelhamid, Adam M Deane
OBJECTIVES: Hypophosphatemia occurs frequently. Enteral, rather than IV, phosphate replacement may reduce fluid replacement, cost, and waste. DESIGN: Prospective, randomized, parallel group, noninferiority clinical trial. SETTING: Single center, 42-bed state trauma, medical and surgical ICUs, from April 20, 2022, to July 1, 2022. PATIENTS: Patients with serum phosphate concentration between 0.3 and 0.75 mmol/L. INTERVENTIONS: We randomized patients to either enteral or IV phosphate replacement using electronic medical record-embedded program...
March 25, 2024: Critical Care Medicine
https://read.qxmd.com/read/38537174/preparation-of-antibacterial-biobased-fibers-by-triaxial-microfluidic-spinning-technology-using-ionic-liquids-as-the-solvents
#2
JOURNAL ARTICLE
Zhimin Zhao, Junlei Wang, Hanmeng Yuan, Jie Xu, Hongshuai Gao, Yi Nie
Bacterial infections have become a serious threat to public health. The utilization of antibacterial textiles offers an effective way to combat bacterial infections at the source, instead of relying solely on antibiotic consumption. Herein, efficient and durable antibacterial fibers based on quercetin and cellulose were prepared by a triaxial microfluidic spinning technology using ionic liquids (ILs) as the solvents. It was indicated that the structure and properties of the antibacterial fibers were affected by the type of IL and the flow rates during the triaxial microfluidic spinning process...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38537038/novel-optical-coherence-tomography-findings-in-a-patient-with-methanol-toxicity-a-case-report
#3
Burcu Işık, Mehmet Giray Ersoz, Mehmet Dokur, Ismail Yıldız, Mehmet Sami Islamoğlu
We report a case of acute methanol toxicity with unique optical coherence tomography findings. A 56-year-old man was referred to our ophthalmology clinic with a history of handmade vodka consumption and vision loss. On ophthalmologic examination, his vision was 20/100 in his right eye and 20/200 in his left eye. Bilateral mild optic disk hyperemia was detected on fundus examination. Because of the severity of systemic symptoms in such cases, it is very difficult to include optical coherence tomography in the ophthalmologic examination...
2024: Arquivos Brasileiros de Oftalmologia
https://read.qxmd.com/read/38537028/niobium-oxyhydroxide-as-a-bioactive-agent-and-reinforcement-to-a-high-viscosity-bulk-fill-resin-composite
#4
JOURNAL ARTICLE
Alyssa Teixeira Obeid, Tatiana Rita de Lima Nascimento, Ana Carolina Agassi, Ana Zélia Falcão Almeida, Ana Paula de Melo Alves Guedes, João Marco Alves, Juliana Fraga Soares Bombonatti, Marilia Mattar de Amoêdo Campos Velo
OBJECTIVE: The present in vitro study incorporated niobium oxyhydroxide fillers into an experimental high-viscosity bulk-fill resin composite to improve its mechanical performance and provide it a bioactive potential. METHODOLOGY: Scanning electron microscopy synthesized and characterized 0.5% niobium oxyhydroxide fillers, demonstrating a homogeneous morphology that represented a reinforcement for the feature. Fillers were weighed, gradually added to the experimental resin composite, and homogenized for one minute, forming three groups: BF (experimental high-viscosity bulk-fill resin composite; control), BF0...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38536922/the-sun-s-differential-rotation-is-controlled-by-high-latitude-baroclinically-unstable-inertial-modes
#5
JOURNAL ARTICLE
Yuto Bekki, Robert H Cameron, Laurent Gizon
Rapidly rotating fluids have a rotation profile that depends only on the distance from the rotation axis, in accordance with the Taylor-Proudman theorem. Although the Sun was expected to be such a body, helioseismology showed that the rotation rate in the convection zone is closer to constant on radii. It has been postulated that this deviation is due to the poles being warmer than the equator by a few degrees. Using numerical simulations, we show that the pole-to-equator temperature difference cannot exceed 7 kelvin as a result of the back-reaction of the high-latitude baroclinically unstable inertial modes...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536887/endothelial-and-inflammatory-pathophysiology-in-dengue-shock-new-insights-from-a-prospective-cohort-study-in-vietnam
#6
JOURNAL ARTICLE
Angela McBride, Huynh Thi Le Duyen, Nguyen Lam Vuong, Phan Vinh Tho, Luong Thi Hue Tai, Nguyen Thanh Phong, Nguyen Thanh Ngoc, Lam Minh Yen, Phung Tran Huy Nhat, Tran Thuy Vi, Martin J Llewelyn, Louise Thwaites, Nguyen Van Hao, Sophie Yacoub
Dengue shock (DS) is the most severe complication of dengue infection; endothelial hyperpermeability leads to profound plasma leakage, hypovolaemia and extravascular fluid accumulation. At present, the only treatment is supportive with intravenous fluid, but targeted endothelial stabilising therapies and host immune modulators are needed. With the aim of prioritising potential therapeutics, we conducted a prospective observational study of adults (≥16 years) with DS in Vietnam from 2019-2022, comparing the pathophysiology underlying circulatory failure with patients with septic shock (SS), and investigating the association of biomarkers with clinical severity (SOFA score, ICU admission, mortality) and pulmonary vascular leak (daily lung ultrasound for interstitial and pleural fluid)...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536751/elasticity-and-rheology-of-auxetic-granular-metamaterials
#7
JOURNAL ARTICLE
Daan Haver, Daniel Acuña, Shahram Janbaz, Edan Lerner, Gustavo Düring, Corentin Coulais
The flowing, jamming, and avalanche behavior of granular materials is satisfyingly universal and vexingly hard to tune: A granular flow is typically intermittent and will irremediably jam if too confined. Here, we show that granular metamaterials made from particles with a negative Poisson's ratio yield more easily and flow more smoothly than ordinary granular materials. We first create a collection of auxetic grains based on a re-entrant mechanism and show that each grain exhibits a negative Poisson's ratio regardless of the direction of compression...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38536615/quantification-of-unencapsulated-drug-in-target-tissues-demonstrates-pharmacological-properties-and-therapeutic-effects-of-liposomal-topotecan-ff-10850
#8
JOURNAL ARTICLE
Toshifumi Kimura, Ken Okada, Yasushi Morohashi, Yukio Kato, Mikinaga Mori, Hiroshi Kato, Takeshi Matsumoto, Susumu Shimoyama
PURPOSE: Quantifying unencapsulated drug concentrations in tissues is crucial for understanding the mechanisms underlying the efficacy and safety of liposomal drugs; however, the methodology for this has not been fully established. Herein, we aimed to investigate the enhanced therapeutic potential of a pegylated liposomal formulation of topotecan (FF-10850) by analyzing the concentrations of the unencapsulated drug in target tissues, to guide the improvement of its dosing regimen. METHODS: We developed a method for measuring unencapsulated topotecan concentrations in tumor and bone marrow interstitial fluid (BM-ISF) and applied this method to pharmacokinetic assessments...
March 27, 2024: Pharmaceutical Research
https://read.qxmd.com/read/38536604/oral-microbiota-and-porphyromonas-gingivalis-kgp-genotypes-altered-in-parkinson-s-disease-with-mild-cognitive-impairment
#9
JOURNAL ARTICLE
Dongcheng Li, Tengzhu Ren, Hao Li, Mingdi Huang, Jiaxin Chen, Qishan He, Wei Lv, Hailing Liu, Renshi Xu, Xiong Zhang
Cognitive impairment (CI) is a common complication of the non-motor symptoms in Parkinson's disease (PD), including PD with mild cognitive impairment (PD-MCI) and PD dementia. Recent studies reported the oral dysbiosis in PD and CI, respectively. Porphyromonas gingivalis (P. gingivalis), a pathogen of oral dysbiosis, plays an important role in PD, whose lysine-gingipain (Kgp) could lead to AD-type pathologies. No previous study investigated the composition of oral microbiota and role of P. gingivalis in PD-MCI...
March 27, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38536531/minimally-invasive-approaches-to-diagnose-and-monitor-eosinophilic-gi-diseases
#10
REVIEW
Ellie J M Furuta, Glenn T Furuta, Robin Shandas
PURPOSE OF REVIEW: This review seeks to understand novel avenues for eosinophilic GI disease management. Biomarkers offer a unique and non-invasive approach to tracking EoE disease progression. While no biomarkers have definitively met the diagnostic criteria for eosinophilic GI diseases, some biomarkers have been shown to be associated with disease activity. Here, we examine the potential of recently studied biomarkers. RECENT FINDINGS: Current research shows advancements in blood, luminal fluid, and breath testing...
March 27, 2024: Current Allergy and Asthma Reports
https://read.qxmd.com/read/38536461/esr-essentials-mri-of-the-knee-practice-recommendations-by-essr
#11
REVIEW
Anagha P Parkar, Miraude E A P M Adriaensen
Many studies and systematic reviews have been published about MRI of the knee and its structures, discussing detailed anatomy, imaging findings, and correlations between imaging and clinical findings. This paper includes evidence-based recommendations for a general radiologist regarding choice of imaging sequences and reporting basic MRI examinations of the knee. We recommend using clinicians' terminology when it is applicable to the imaging findings, for example, when reporting meniscal, ligament and tendon, or cartilage pathology...
March 27, 2024: European Radiology
https://read.qxmd.com/read/38536455/matching-proposed-clinical-and-mri-criteria-of-aggressive-multiple-sclerosis-to-serum-and-cerebrospinal-fluid-markers-of-neuroaxonal-and-glial-injury
#12
JOURNAL ARTICLE
Martin A Schaller-Paule, Michelle Maiworm, Jan Hendrik Schäfer, Lucie Friedauer, Elke Hattingen, Katharina Johanna Wenger, Frank Weber, Jasmin Jakob, Falk Steffen, Stefan Bittner, Yavor Yalachkov, Christian Foerch
BACKGROUND: Definitions of aggressive MS employ clinical and MR imaging criteria to identify highly active, rapidly progressing disease courses. However, the degree of overlap between clinical and radiological parameters and biochemical markers of CNS injury is not fully understood. Aim of this cross-sectional study was to match clinical and MR imaging hallmarks of aggressive MS to serum/CSF markers of neuroaxonal and astroglial injury (neurofilament light chain (sNfL, cNfL), and glial fibrillary acidic protein (sGFAP, cGFAP))...
March 27, 2024: Journal of Neurology
https://read.qxmd.com/read/38536217/exploring-high-pressure-polymorphism-in%C3%A2-carbonic-acid-through-direct-synthesis-from%C3%A2-carbon-dioxide-clathrate-hydrate
#13
JOURNAL ARTICLE
Selene Berni, Demetrio Scelta, Sebastiano Romi, Samuele Fanetti, Frederico Alabarse, Marco Pagliai, Roberto Bini
Carbon dioxide (CO2) is widespread in astrochemically relevant environments, often coexisting with water (H2O) ices and thus triggering a great interest regarding the possible formation of their adducts under various thermodynamic conditions. Amongst them, solid carbonic acid (H2CO3) remains elusive, yet being widely studied. Synthetic routes followed for its production have always been characterised by drastic irradiation on solid ice mixtures or complex procedures on fluid samples (such as laser heating at moderate to high pressures)...
March 27, 2024: Angewandte Chemie
https://read.qxmd.com/read/38536200/incidence-risk-factors-and-outcome-of-asymptomatic-central-nervous-system-involvement-in-adult-patients-with-acute-myeloid-leukemia
#14
JOURNAL ARTICLE
Marijana Virijevic, Nada Kraguljac-Kurtovic, Mirjana Mitrovic, Ljubomir Jakovic, Zoran Bukumuric, Nikola Pantic, Nikica Sabljic, Zlatko Pravdic, Mirjana Cvetkovic, Vesna Knezevic, Tijana Dragovic-Ivancevic, Irena Djunić, Jovan Rajic, Violeta Milosevic, Milena Todorovic-Balint, Ana Vidovic, Nada Suvajdzic-Vukovic
Examination of central nervous system (CNS) involvement is not routine diagnostic practice in adult patients with acute myeloid leukemia (AML). Therefore, many asymptomatic patients with CNS involvement might go undetected. The effect of CNS involvement on the AML disease course is not well defined, with conflicting results regarding clinical outcome. This study aimed to determine the incidence of asymptomatic CNS involvement in AML estimated by multiparametric flow cytometry of cerebrospinal fluid (MFC-CSF) at diagnosis, the related potential risk factors, and prognosis...
March 2024: Hematological Oncology
https://read.qxmd.com/read/38536197/adamts5-promotes-permeability-of-the-blood-brain-barrier-during-treponema-pallidum-subspecies-pallidum-invading-the-central-nervous-system
#15
JOURNAL ARTICLE
Zuoxi Chen, Fangzhi Du, Ruihua Zhang, Qingyun Wu, Zhiyu Lu, Rui-Li Zhang, Qianqiu Wang
The pathogenesis of neurosyphilis remains unclear. A previous study found a noteworthy up-regulation of a disintegrin and metalloproteinase with thrombospondin type 1 motif 5 (ADAMTS5) gene in human brain microvascular endothelial cells cocultured with Treponema pallidum subspecies pallidum (Tp). To investigate the ADAMTS5 role in Tp invading the central nervous system (CNS), we conducted relevant experiments. Our study revealed that Tp caused an increase in human cortical microvascular endothelial cell/D3 (hCMEC/D3) barrier permeability and significantly enhanced ADAMTS5 expression...
March 27, 2024: ACS Infectious Diseases
https://read.qxmd.com/read/38536144/free-energy-density-of-a-fluid-and-its-role-in-solvation-and-binding
#16
JOURNAL ARTICLE
Michael K Gilson, Tom Kurtzman
The concept that a fluid has a position-dependent free energy density appears in the literature but has not been fully developed or accepted. We set this concept on an unambiguous theoretical footing via the following strategy. <u>First</u>, we set forth four desiderata that should be satisfied by any definition of the position-dependent free energy density, f ( R ), in a system comprising only a fluid and a rigid solute: its volume integral, plus the fixed internal energy of the solute, should be the system free energy; it deviates from its bulk value, f bulk , near a solute but should asymptotically approach f bulk with increasing distance from the solute; it should go to zero where the solvent density goes to zero; and it should be well-defined in the most general case of a fluid made up of flexible molecules with an arbitrary interaction potential...
March 27, 2024: Journal of Chemical Theory and Computation
https://read.qxmd.com/read/38536127/the-impact-of-low-energy-partially-hydrolysed-enteral-formula-on-gastrointestinal-symptoms-and-weight-in-children-with-neurological-impairment-a-multicentre-retrospective-study
#17
JOURNAL ARTICLE
Graeme O'Connor, Martha Van Der Linde, Zoltan Hartfiel Capriles
BACKGROUND: Neurological impairment (NI) relates to disorders of the central nervous system. The specific aetiology of NI varies but includes genetic, congenital abnormalities or brain injury. In children with severe NI, feeding impairments can lead to undernutrition, and some children require a feeding tube. Although tube feeding improves overall nutritional status, it has also been associated with excess body fat. Commercially available enteral formulas that are low in energy, hydrolysed and nutritionally adequate for protein and micronutrients are available to mitigate gastrointestinal symptoms and obesity...
March 27, 2024: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://read.qxmd.com/read/38536072/pure-elongation-flow-of-an-electrorheological-fluid-insights-on-wall-slip-from-electrorheology
#18
JOURNAL ARTICLE
Ishu Chaudhary, Manish Kaushal
In this work we study the pure elongation flow behavior of an electrorheological (ER) fluid as a model soft-jammed system, wherein the extent of jamming is controlled by an externally applied electric-field. More specifically, a pure elongation flow has been achieved by facilitating significant slip at the contact between the material and rheometer-plate while pulling it with constant pulling velocity under a constant external electric-field. The normal force exerted by the top plate on the material was measured as a function of gap during the flow for various combinations of electric-field strength and pulling velocity...
March 27, 2024: Soft Matter
https://read.qxmd.com/read/38536066/hydrodynamically-induced-aggregation-of-two-dimensional-oriented-active-particles
#19
JOURNAL ARTICLE
Roee Bashan, Naomi Oppenheimer
We investigate a system of co-oriented active particles interacting only via hydrodynamic and steric interactions in a two-dimensional fluid. We offer a new method of calculating the flow created by any active particle in such a fluid, focusing on the dynamics of flow fields with a high-order spatial decay, which we analyze using a geometric Hamiltonian. We show that when the particles are oriented and the flow has a single, odd power decay, such systems lead to stable, fractal-like aggregation, with the only exception being the force dipole...
March 27, 2024: Soft Matter
https://read.qxmd.com/read/38536028/insights-on-obstetric-outcomes-in-pregnant-individuals-with-marfan-syndrome-evidence-from-the-national-inpatient-sample
#20
JOURNAL ARTICLE
Saeed Baradwan, Majed S Alshahrani, Khalid Khadawardi, Maha Tulbah, Osama Alomar, Abdullah Alyousef, Ibtihal A Bukhari, Ahmed Abu-Zaid
BACKGROUND: We investigated the potential association between Marfan Syndrome (MFS) and adverse obstetric outcomes using the National Inpatient Sample (NIS) database. METHODS: We utilized the International Classification of Diseases (ICD-10) system to identify relevant codes and extracted data from the NIS database covering the period 2016-2019. Descriptive statistics and χ2 tests were employed to summarize and compare baseline characteristics. Univariate and multivariate regression analyses (adjusted for age, race, hospital region, smoking status, and alcohol misuse) were conducted to evaluate association between MFS and adverse obstetric outcomes...
March 27, 2024: Minerva obstetrics and gynecology
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