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https://www.readbyqxmd.com/read/28732338/toxic-organic-substances-and-marker-compounds-in-size-segregated-urban-particulate-matter-implications-for-involvement-in-the-in%C3%A2-vitro-bioactivity-of-the-extractable-organic-matter
#1
Athanasios Besis, Alexandra Tsolakidou, Dimitra Balla, Constantini Samara, Dimitra Voutsa, Anastasia Pantazaki, Theodora Choli-Papadopoulou, Theodore S Lialiaris
Toxic organic substances and polar organic marker compounds, i.e. polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), polycyclic aromatic hydrocarbons (PAHs) and their nitro-derivatives (N-PAHs), as well as dicarboxylic acids (DCAs) and sugars/sugar anhydrites (S/SAs) were analyzed in size-segregated PM samples (<0.49, 0.49-0.97, 0.97-3 and >3 μm) collected at two urban sites (urban traffic and urban background) during the cold and the warm season...
July 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28732041/understanding-russell-s-viper-venom-factor-v-activator-s-substrate-specificity-by-surface-plasmon-resonance-and-in-silico-studies
#2
Pradeep K Yadav, Christian B Antonyraj, Syed Ibrahim Basheer Ahamed, Sistla Srinivas
Blood coagulation factor V (FV) is activated either by Factor X or thrombin, cleaving at three different sites viz., Site I (Arg709-Ser710), site II (Arg1018-Thr1019), and site III (Arg1545-Ser1546). Russell's viper venom factor V activator (RVV-V) is a thrombin-like serine proteinase that activates FV with selective, single cleavage at site III. A long lasting effort is being pending in understanding the 'selective' binding specificity of the RVV-V towards site III. Here, we present the binding kinetic study of RVV-V with two designed peptides corresponding to the regions from site I (Gln699-Asn713) and site II (1008Lys-Pro1022), respectively, that include 15 amino acids...
2017: PloS One
https://www.readbyqxmd.com/read/28731933/continuous-capnography-reduces-the-incidence-of-opioid-induced-respiratory-rescue-by-hospital-rapid-resuscitation-team
#3
Mindy Stites, Jennifer Surprise, Jennifer McNiel, David Northrop, Martin De Ruyter
OBJECTIVE: The aim of this study was to determine the impact of end tidal carbon dioxide or capnography monitoring in patients requiring patient-controlled analgesia (PCA) on the incidence of opioid-induced respiratory depression (OIRD) in the setting of rapid response. METHODS: A retrospective analysis was conducted in an urban tertiary care facility on the incidence of OIRD in the setting of rapid response as defined by a positive response to naloxone from January 2012 to December 2015...
July 20, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28731694/the-foliar-desiccators-glyphosate-carfentrazone-and-paraquat-affect-the-technological-and-chemical-properties-of-cowpea-grains
#4
Igor da Silva Lindemann, Gustavo Heinrich Lang, Jessica Fernanda Hoffmann, Cesar Valmor Rombaldi, Mauricio de Oliveira, Moacir Cardoso Elias, Nathan Levien Vanier
The effects of the use of glyphosate (GLY), glyphosate plus carfentrazone (GLY/CAR), and paraquat (PAR) as plant desiccators on the technological and chemical properties of cowpea grains were investigated. All studied desiccants provided lower cooking time to freshly harvested cowpea. However, the coat color of PAR- and GLY/CAR-treated cowpea was reddish than control treatment. Principal component analysis (PCA) from liquid chromatography-mass spectrometry (LC-MS) data sets showed a clear distinction among cowpea from the different treatments...
July 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28731549/development-and-validation-of-the-dietetic-confidence-scale-for-working-with-clients-experiencing-psychological-issues
#5
Kerryn Buttenshaw, Susan Ash, Jane Shakespeare-Finch
AIM: A standardised tool was needed to measure a generalist dietitian's confidence about working with clients experiencing psychological issues in order to effectively evaluate mental health-related professional development activities. The aim of this study was to develop, pilot and validate a robust instrument that measures a generalist dietitian's professional confidence for working with clients experiencing psychological issues. METHODS: The Dietetic Confidence Scale (DCS) was developed...
February 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28731316/phytochemical-analysis-of-myrtus-communis-plant-conventional-versus-microwave-assisted-extraction-procedures
#6
Nadia Bouaoudia-Madi, Lila Boulekbache-Makhlouf, Nabil Kadri, Farid Dahmoune, Hocine Remini, Sofiane Dairi, Sonia Oukhmanou-Bensidhoum, Khodir Madani
Background Myrtle (Myrtus communis L) may constitute an interesting dietary source of health protective compounds. Microwave-assisted extraction (MAE) of total phenolic compounds (TPC) from myrtle leaf, stems, pericarp, and seeds was studied and the results were compared with those of the conventional method extraction (CME) in terms of extraction time. Methods Extraction yield/efficiency and antioxidant activity were measured using radical scavenging assay (DPPH•) and reducing power. Results The results show that the MAE was higher in terms of saving energy, extraction time (62 s) and extraction efficiency of bioactive compound compared to CME (2 h)...
June 10, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28730787/association-of-ferritin-with-prostate-cancer
#7
Qiang Su, Ting Lei, Man Zhang
PURPOSE: Prostate specific antigen (PSA) has been widely used as the unique serum biomarker for the diagnosis and/ or pre-diagnosis of prostate cancer (PCa). However, the diagnostic value of PSA is a subject of ongoing debate owing to its lack of specificity, especially when the PSA level is moderately increased (e.g., 4-10 ng/ml). Thus, we suggest the need for identification of a new biomarker to discriminate PCa cases from benign prostatic hyperplasia (BPH) and normal controls (N). METHODS: Urine or tissue samples of PCa patients, BPH patients, and normal controls were systematically collected...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28730328/comparative-study-of-the-efficacy-of-transdermal-buprenorphine-patches-and-prolonged-release-tramadol-tablets-for-postoperative-pain-control-after-spinal-fusion-surgery-a-prospective-randomized-controlled-non-inferiority-trial
#8
Ho-Joong Kim, Hyo Sae Ahn, Yunjin Nam, Bong-Soon Chang, Choon-Ki Lee, Jin S Yeom
PURPOSE: To compare the efficacy of a transdermal buprenorphine patch (5, 10, 15, and 20 μg/h) with that of oral tramadol (150, 200, 250, and 300 mg) for postoperative pain control after single level spinal fusion surgery. METHODS: The present study (ClinicalTrials.gov, number NCT02416804) was a prospective, randomized controlled non-inferiority trial designed to determine the efficacy of buprenorphine TDS for alleviating postoperative pain following patient controlled analgesia (PCA) in persons underwent a single level posterior lumbar interbody fusion surgery through 1:1 allocation...
July 20, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28727892/end-of-life-experiences-of-family-caregivers-of-deceased-patients-with-cancer-a-nation-wide-survey
#9
Kayo Hirooka, Hiroyuki Otani, Tatsuya Morita, Tomofumi Miura, Hiroki Fukahori, Maho Aoyama, Yoshiyuki Kizawa, Yasuo Shima, Satoru Tsuneto, Mitsunori Miyashita
OBJECTIVES: The purpose of this study was (1) to describe the end-of-life experience of family caregivers of cancer patients, (2) to describe talking about death and dying of the patient to minor children, and (3) to examine the association of family caregivers' experiences by their characteristics and talking about death and dying of the patient. METHODS: A cross-sectional nationwide survey of bereaved family caregivers was conducted. In total, 968 questionnaires were sent to bereaved family caregivers, and 711 were completed and returned...
July 20, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28727569/comparing-the-performance-of-linear-and-nonlinear-principal-components-in-the-context-of-high-dimensional-genomic-data-integration
#10
Shofiqul Islam, Sonia Anand, Jemila Hamid, Lehana Thabane, Joseph Beyene
Linear principal component analysis (PCA) is a widely used approach to reduce the dimension of gene or miRNA expression data sets. This method relies on the linearity assumption, which often fails to capture the patterns and relationships inherent in the data. Thus, a nonlinear approach such as kernel PCA might be optimal. We develop a copula-based simulation algorithm that takes into account the degree of dependence and nonlinearity observed in these data sets. Using this algorithm, we conduct an extensive simulation to compare the performance of linear and kernel principal component analysis methods towards data integration and death classification...
July 20, 2017: Statistical Applications in Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28727421/shallow-representation-learning-via-kernel-pca-improves-qsar-modelability
#11
Stefano E Rensi, Russ B Altman
Linear models offer a robust, flexible, and computationally efficient set of tools for modeling quantitative structure activity relationships (QSAR), but have been eclipsed in performance by non-linear methods. Support vector machines (SVMs) and neural networks are currently among the most popular and accurate QSAR methods because they learn new representations of the data that greatly improve modelability. In this work we use shallow representation learning to improve the accuracy of L1 regularized logistic regression (LASSO) and meet the performance of Tanimoto SVM...
July 20, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28727387/focal-cryotherapy-step-by-step-technique-description
#12
Cristina Redondo, Victor Srougi, José Batista da Costa, Mohammed Baghdad, Guillermo Velilla, Igor Nunes-Silva, Sebastien Bergerat, Silvia Garcia-Barreras, François Rozet, Alexandre Ingels, Marc Galiano, Rafael Sanchez-Salas, Eric Barret, Xavier Cathelineau
INTRODUCTION AND OBJECTIVE: Focal cryotherapy emerged as an efficient option to treat favorable and localized prostate cancer (PCa). The purpose of this video is to describe the procedure step by step. MATERIALS AND METHODS: We present the case of a 68 year-old man with localized PCa in the anterior aspect of the prostate. RESULTS: The procedure is performed under general anesthesia, with the patient in lithotomy position. Briefly, the equipament utilized includes the cryotherapy console coupled with an ultrasound system, argon and helium gas bottles, cryoprobes, temperature probes and an urethral warming catheter...
July 20, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28726573/investigating-variations-of-fluorescent-dissolved-organic-matter-in-wastewater-treatment-using-synchronous-fluorescence-spectroscopy-combined-with-principal-component-analysis-and-two-dimensional-correlation
#13
Hongwei Pan, Huibin Yu, Yanan Wang, Ruixia Liu, Hongjun Lei
Synchronous fluorescence spectroscopy (SFS) combined with principal component analysis (PCA) and two-dimensional (2D) correlation was applied to investigate removal efficiencies and variations of dissolved organic matter (DOM) fractions in the wastewater treatment plant (WWTP) with an A2O craft. A decreasing order of total removal efficiencies was tyrosine-like fluorescence component (89.58%) > humic-like fluorescence component (39.83%) > tryptophan-like fluorescence component (36.89%) > microbial humic-like fluorescence component (12...
July 20, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28726241/investigating-the-role-of-the-igf-axis-as-a-predictor-of-biochemical-recurrence-in-prostate-cancer-patients-post-surgery
#14
Kieran J Breen, Amanda O'Neill, Lisa Murphy, Yue Fan, Susie Boyce, Noel Fitzgerald, Emma Dorris, Lauren Brady, Stephen P Finn, Brian D Hayes, Ann Treacy, Ciara Barrett, Mardiana Abdul Aziz, Elaine W Kay, John M Fitzpatrick, R William G Watson
BACKGROUND: Between 20% and 35% of prostate cancer (PCa) patients who undergo treatment with curative intent (ie, surgery or radiation therapy) for localized disease will experience biochemical recurrence (BCR). Alterations in the insulin-like growth factor (IGF) axis and PTEN expression have been implicated in the development and progression of several human tumors including PCa. We examined the expression of the insulin receptor (INSR), IGF-1 receptor (IGF-1R), PTEN, and AKT in radical prostatectomy tissue of patients who developed BCR post-surgery...
July 20, 2017: Prostate
https://www.readbyqxmd.com/read/28725867/revisiting-the-psychometric-properties-of-the-scoliosis-research-society-22-srs-22-french-version
#15
Jean Théroux, Norman Stomski, Stanley Innes, Ariane Ballard, Christelle Khadra, Hubert Labelle, Sylvie Le May
BACKGROUND: Adolescent idiopathic scoliosis (AIS) is among the most common spinal deformities affecting adolescents. The Scoliosis Research Society-22 questionnaire is commonly used to assess health-related quality of life in AIS patients, including pain. The objective of this study is to verify the psychometric properties of the Scoliosis Research Society-22 French version (SRS-22fv) questionnaire. METHODS: A prospective methodological design was used to verify the psychometric properties of the French version of the SRS-22fv...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28725622/authentication-of-piper-betle-l-folium-and-quantification-of-their-antifungal-activity
#16
I Made Agus Gelgel Wirasuta, I Gusti Ayu Made Srinadi, Ida Bagus Gede Dwidasmara, Ni Luh Putu Putri Ardiyanti, I Gusti Ayu Arya Trisnadewi, Ni Luh Putu Vidya Paramita
The TLC profiles of intra- and inter-day precision for Piper betle L. (PBL) folium methanol extract was studied for their peak marker recognition and identification. The Numerical chromatographic parameters (NCPs) of the peak markers, the hierarchical clustering analysis (HCA) and the principal component analysis (PCA) were applied to authenticate the PBL. folium extract from other Piper species folium extract and to ensure the antifungal activity quality of the PBL essential oil. The spotted extract was developed with the mobile phase of toluene: ethyl acetate; 93:7, (v/v)...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28725600/endogenous-and-exogenous-testosterone-and-prostate-cancer-decreased-increased-or-null-risk
#17
REVIEW
David S Lopez, Shailesh Advani, Konstantinos K Tsilidis, Run Wang, Steven Canfield
For more than 70 years, the contention that high levels of testosterone or that the use of testosterone therapy (TTh) increases the development and progression of prostate cancer (PCa) has been widely accepted and practiced. Yet, the increasing and emerging evidence on testosterone research seems to challenge that contention. To review literature on the associations of endogenous and exogenous testosterone with decreased-, increased-, or null-risk of PCa, and to further evaluate only those studies that reported magnitude of associations from multivariable modeling as it minimizes confounding effects...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725597/canine-prostate-models-in-preclinical-studies-of-minimally-invasive-interventions-part-i-canine-prostate-anatomy-and-prostate-cancer-models
#18
REVIEW
Fei Sun, Claudia Báez-Díaz, Francisco Miguel Sánchez-Margallo
The high prevalence of prostate cancer (PCa) in elderly men and technical advances in early detection of localized PCa have led to continued efforts to develop new therapeutic options of minimally invasive nature in current urologic oncology community. Increasing newly emerging therapies are undergoing preclinical tests on the technical feasibility, efficacy and safety in animal experiments. The dog is an ideal large animal because of its similar anatomy to human and the capability allowing the use of the same medical devices applied in future clinical trials...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725592/is-contrast-enhancement-needed-for-diagnostic-prostate-mri
#19
REVIEW
Michele Scialpi, Valeria Rondoni, Maria Cristina Aisa, Eugenio Martorana, Alfredo D'Andrea, Corrado Maria Malaspina, Agostino Orlandi, Giorgio Galassi, Emanuele Orlandi, Pietro Scialpi, Michele Dragone, Diego Palladino, Annalisa Simeone, Michele Amenta, Giampaolo Bianchi
Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) provides clinical guidelines for multiparametric magnetic resonance imaging (mpMRI) [T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)] of prostate. However, DCE-MRI seems to show a limited contribution in prostate cancer (PCa) detection and management. In our experience, DCE-MRI, did not show significant change in diagnostic performance in addition to DWI and T2WI [biparametric MRI (bpMRI)] which represent the predominant sequences to detect suspected lesions in peripheral and transitional zone (TZ)...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725591/diffusion-weighted-imaging-of-the-prostate-principles-application-and-advances
#20
REVIEW
Martin H Maurer, Johannes T Heverhagen
This review article aims to provide an overview on the principles of diffusion-weighted magnetic resonance imaging (DW-MRI) and its applications in the imaging of the prostate. DW-MRI with regards to different applications for prostate cancer (PCa) detection and characterization, local staging as well as for active surveillance (AS) and tumor recurrence after radical prostatectomy (RP) will be discussed. Furthermore, advances in DW-MRI techniques like diffusion kurtosis imaging (DKI) will be presented.
June 2017: Translational Andrology and Urology
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