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A A Thakur, X Wang, M M Garcia-Betancourt, R A Forse
WHAT IS KNOWN AND OBJECTIVE: Breast cancer (BCa) and prostate cancer (PCa), both hormone-dependent cancers, are the second leading cause of death in both women and men, respectively. Calcium channel blockers (CCBs) have been thought to increase the risk of cancer by inhibiting calcium signal-mediated apoptosis, but the evidence for this association remains inconclusive. We have reviewed pertinent literature and pooled data to establish a consensus on the relationship of CCB use and the incidence of these two cancers...
April 15, 2018: Journal of Clinical Pharmacy and Therapeutics
Andrew K Leung, Lee Hugar, Dattatraya Patil, Lisa Wong, Bradley Carthon, Kenneth Carney, George Birdsong, Kelvin A Moses, Viraj A Master
OBJECTIVE: To characterize men presenting to a tertiary care safety-net hospital with prostate-specific antigen (PSA) values ≥100 ng/mL and identify a potential population for targeted PSA screening. METHODS: Retrospective review of 100 randomly selected patients out of 204 total who presented to Grady Memorial Hospital from 2004-2011 with initial PSA≥100 ng/mL was performed. Demographics, disease characteristics, and survival status were obtained via the Tumor Registry and a combination of electronic medical records and older paper charts, with missing data from paper charts excluded on analyses...
April 12, 2018: Urology
Elena Shumilina, Anastasiya Dykyy, Alexander Dikiy
The ever-increasing demand for fish as a food, has led to the development of new handling and packaging technologies resulting in premium quality fish products. In order to avoid frauds reaching the market, fish quality assurance methods need to be developed. In this study, two statistical models of biochemical processes that occur in Atlantic salmon during two weeks of storage at 0 and 4 °C were developed. These models were further used to detect salmon quality and its storage conditions. The biochemical processes were monitored using Nuclear Magnetic Resonance (NMR) spectroscopy and principal component analysis (PCA)...
August 30, 2018: Food Chemistry
Hui Guo, Zhen Zhang, Yuan Yao, Jialin Liu, Ruirui Chang, Zhao Liu, Hongyuan Hao, Taohong Huang, Jun Wen, Tingting Zhou
Semen sojae praeparatum with homology of medicine and food is a famous traditional Chinese medicine. A simple and effective quality fingerprint analysis, coupled with chemometrics methods, was developed for quality assessment of Semen sojae praeparatum. First, similarity analysis (SA) and hierarchical clusting analysis (HCA) were applied to select the qualitative markers, which obviously influence the quality of Semen sojae praeparatum. 21 chemicals were selected and characterized by high resolution ion trap/time-of-flight mass spectrometry (LC-IT-TOF-MS)...
August 30, 2018: Food Chemistry
Y J Liu, T Tran, G Postma, L M C Buydens, J Jansen
Principal Component Analysis (PCA) is widely used in analytical chemistry, to reduce the dimensionality of a multivariate data set in a few Principal Components (PCs) that summarize the predominant patterns in the data. An accurate estimate of the number of PCs is indispensable to provide meaningful interpretations and extract useful information. We show how existing estimates for the number of PCs may fall short for datasets with considerable coherence, noise or outlier presence. We present here how Angle Distribution of the Loading Subspaces (ADLS) can be used to estimate the number of PCs based on the variability of loading subspace across bootstrap resamples...
August 22, 2018: Analytica Chimica Acta
Mahmoudreza Ovissipour, Setareh Ghorban Shiroodi, Barbara Rasco, Juming Tang, Shyam S Sablani
This study investigated the effect of different electrolyzed water (EO) solutions, including acidic electrolyzed water (AEW) and neutral electrolyzed water (NEW), alone and in combination with mild thermal processing (50, 55, 60, 65 °C) at different exposure times (2, 6, 10 min) on the reduction of Listeria monocytogenes on Atlantic salmon fillets. The effects of the EO water solutions on cell wall structures of L. monocytogenes and on the secondary structure of salmon protein were studied using Fourier Transform Infra-Red (FTIR) spectroscopy...
April 4, 2018: International Journal of Food Microbiology
Yanhong Zhu, Lin Huang, Jingyi Li, Qi Ying, Hongliang Zhang, Xingang Liu, Hong Liao, Nan Li, Zhenxin Liu, Yuhao Mao, Hao Fang, Jianlin Hu
Particulate matter (PM) in the atmosphere has adverse effects on human health, ecosystems, and visibility. It also plays an important role in meteorology and climate change. A good understanding of its sources is essential for effective emission controls to reduce PM and to protect public health. In this study, a total of 239 PM source apportionment studies in China published during 1987-2017 were reviewed. The documents studied include peer-reviewed papers in international and Chinese journals, as well as degree dissertations...
April 10, 2018: Environment International
Emily Karsinti, Kristel Piani, El Hedi Zerdazi, Uwe Maskos, Philippe Faure, Lucia Romo, Frank Bellivier, Georges Brousse, Jean Pierre Lépine, Vanessa Bloch, Florence Vorspan
Little is known regarding between-subject variability in the subjective effects of first cocaine use. This study retrospectively assesses the subjective effects of first cocaine use in 160 current treatment-seeking cocaine use disorder patients. Subjective effects of first cocaine use were evaluated with an ad-hoc questionnaire used for cannabis effects. A principal component analysis (PCA) was performed, with resulting factors correlated with clinical variables (α = 0.05). Four factors emerged in the PCA, namely Anxiety (accounting for 21...
March 29, 2018: Psychiatry Research
De-Zhi Li, Bing-Nan Han, Rui Wei, Gui-Yang Yao, Zhizhen Chen, Jie Liu, Terence C W Poon, Wu Su, Zhongyu Zhu, Dimiter S Dimitrov, Qi Zhao
Site-specific conjugation of small molecules to antibody molecules is a promising strategy for generation of antibody-drug conjugates. In this report, we describe the successful synthesis of a novel bifunctional molecule, 6-(azidomethyl)-2-pyridinecarboxyaldehyde (6-AM-2-PCA), which was used for conjugation of small molecules to peptides and antibodies. We demonstrated that 6-AM-2-PCA selectively reacted with N-terminal amino groups of peptides and antibodies. In addition, the azide group of 6-AM-2-PCA enabled copper-free click chemistry coupling with dibenzocyclooctyne-containing reagents...
April 13, 2018: MAbs
José Manuel Salgado, Daniel Sousa, Armando Venâncio, Isabel Belo
BACKGROUND: Mediterranean agro-food industries, among which are wineries, breweries and olive mills, dispose a great amount of wastes, which generate environmental problems and have a low nutritional value to be used as animal feed. In this sense, solid-state fermentation (SSF) can increase the nutritional value of these wastes and simultaneously produce lignocellulolytic enzymes. RESULTS: All fermented wastes were enriched in protein by the three fungi studied...
April 13, 2018: Journal of the Science of Food and Agriculture
Chunhua Zhou, Zhenshan Xie, Zhouxi Lei, Yuechun Huang, Gang Wei
BACKGROUND: The quality of material medicine resources has had a considerable impact on the development of the health industry, which has created a bottleneck for traditional Chinese medicine (TCM). Dendrobium officinale, which has been widely used for health prevention in TCM, has become a high-nutritive health food that is strongly recommended by many white-collar workers and people who pay more attention to their health. The aim of this study was to develop a method to authenticate and evaluate D...
April 12, 2018: Chemistry Central Journal
Stephanie Robu, Alexander Schmidt, Matthias Eiber, Margret Schottelius, Thomas Günther, Behrooz Hooshyar Yousefi, Markus Schwaiger, Hans-Jürgen Wester
BACKGROUND: Due to its high and consistent expression in prostate cancer (PCa), the prostate-specific membrane antigen (PSMA) represents an ideal target for molecular imaging and targeted therapy using highly specific radiolabeled PSMA ligands. To address the continuously growing clinical demand for 18 F-labeled PSMA-probes, we developed two novel Glu-urea-Glu-(EuE)-based inhibitors, EuE-k-18 F-FBOA (1) and EuE-k-β-a-18 F-FPyl (2), both with optimized linker structure and different 18 F-labeled aromatic moieties...
April 12, 2018: EJNMMI Research
Guanglin He, Zheng Wang, Xing Zou, Xu Chen, Jing Liu, Mengge Wang, Yiping Hou
Non-CODIS STRs, with high polymorphism and allele frequency difference among ethnically and geographically different populations, play a crucial role in population genetics, molecular anthropology, and human forensics. In this work, 332 unrelated individuals from Sichuan Province (237 Tibetan individuals and 95 Yi individuals) are firstly genotyped with 21 non-CODIS autosomal STRs, and phylogenetic relationships with 26 previously investigated populations (9,444 individuals) are subsequently explored. In the Sichuan Tibetan and Yi, the combined power of discrimination (CPD) values are 0...
April 12, 2018: Scientific Reports
Emilio Rubén Pego, Isaac Fernández, María Jesús Núñez
INTRODUCTION AND OBJECTIVE: Prostate cancer (PCa) is the second most common cancer in men especially after 50 years old. The metastasis of said cancer involves a rise for morbidity, metastasizing 90% of the occasions on bone. Metalloproteinases (MMPs) are involved in the process of bone formation and they are postulated to be involved in the process of metastasizing, in particular MMP-9. This work is justified taking into account the scientific interest of the subject and the quality of the literature sources used...
April 9, 2018: Urologic Oncology
Per Munck Af Rosenschold, Michael J Zelefsky, Aditya P Apte, Andrew Jackson, Jung Hun Oh, Elliot Shulman, Neil Desai, Margie Hunt, Pirus Ghadjar, Ellen Yorke, Joseph O Deasy
BACKGROUND: To determine if reduced dose delivery uncertainty is associated with daily image-guidance (IG) and Prostate Specific Antigen Relapse Free Survival (PRFS) in intensity-modulated radiotherapy (IMRT) of high-risk prostate cancer (PCa). METHODS: Planning data for consecutive PCa patients treated with IMRT (n = 67) and IG-IMRT (n = 35) was retrieved. Using computer simulations of setup errors, we estimated the patient-specific uncertainty in accumulated treatment dose distributions for the prostate and for posterolateral aspects of the gland that are at highest risk for extra-capsular disease...
April 12, 2018: Radiation Oncology
Alireza Mazloumi Gavgani, Rachel H X Wong, Peter R C Howe, Deborah M Hodgson, Frederick R Walker, Eugene Nalivaiko
Our aim was to assess cerebral blood flow changes during cybersickness. Transcranial Doppler (TCD) ultrasound and near infrared spectroscopy (NIRS) were used separately in two independent experiments. In both studies, a 15-min virtual roller coaster ride was used as a provocative visual stimulus. Subjective nausea ratings were obtained at 1 min intervals. The TCD study was performed in 14 healthy subjects (8 males and 6 females); in this study we also measured heart rate and arterial pressure. In a separate study a 52-channel NIRS device (Hitachi ETG-4000) was used to monitor activated brain regions by measuring oxy-hemoglobin (HbO2) concentration in 9 healthy subjects (4 male, 5 females)...
April 9, 2018: Physiology & Behavior
Beth Russell, Hans Garmo, Kerri Beckmann, Pär Stattin, Jan Adolfsson, Mieke Van Hemelrijck
OBJECTIVES: To investigate the association between lower urinary-tract infections, their associated antibiotics and the subsequent risk of developing PCa. SUBJECTS/PATIENTS (OR MATERIALS) AND METHODS: Using data from the Swedish PCBaSe 3.0, we performed a matched case-control study (8762 cases and 43806 controls). Conditional logistic regression analysis was used to assess the association between lower urinary-tract infections, related antibiotics and PCa, whilst adjusting for civil status, education, Charlson Comorbidity Index and time between lower urinary-tract infection and PCa diagnosis...
2018: PloS One
Andrea Schramm, Philip Mueller-Thuemen, Timo Littmann, Manuela Harloff, Takeaki Ozawa, Jens Schlossmann
Nitric oxide (NO/cyclic guanosine monophosphate (cGMP)-regulated cellular mechanisms are involved in a variety of (patho-) physiological processes. One of the main effector molecules in this system, proteinkinase G (PKG), serves as a molecular switch by phosphorylating different target proteins and thereby turning them on or off. To date, only a few interaction partners of PKG have been described although the identification of protein-protein interactions (PPI) is indispensable for the understanding of cellular processes and diseases...
April 12, 2018: International Journal of Molecular Sciences
Marina Massoud, A Y Rosalie Kühlmann, Monique van Dijk, Lonneke M Staals, Rene M H Wijnen, Joost van Rosmalen, Cornelius E J Sloots, Claudia M G Keyzer-Dekker
BACKGROUND: Postoperatively, young infants are admitted overnight in view of the risk for respiratory complications such as desaturation and apnea. This risk seems much lower than previously reported. Until what age this risk persists, and which infants might actually qualify for day-care treatment, is unknown. METHODS: We retrospectively reviewed medical charts from preterm infants <45 weeks postconceptional age (PCA), 45-60 weeks PCA, and term infants <3 months admitted overnight after inguinal hernia repair, from January 2011 to December 2015 in a large tertiary children's hospital...
April 11, 2018: Anesthesia and Analgesia
Chaohong Chen, Zhifeng He, Deyao Xie, Liangcheng Zheng, Tianhao Zhao, Xinbo Zhang, Dezhi Cheng
Anaplastic lymphoma kinase (ALK) has been regarded as an essential target for the treatment of non-small cell lung cancer (NSCLC). However, the emergence of G1202R solvent front mutation that confer resistance to the drugs were reported for the first as well as the second generation ALK inhibitors. It was supposed that the G1202R solvent front mutation might hinder the drug binding. In this study, a different fact could be clarified by multiple molecular modeling methodologies through a structural analogue of ceritinib (compound 10, Cpd-10) that is reported to be a potent inhibitor against the G1202R mutation...
April 12, 2018: Journal of Physical Chemistry. B
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