keyword
MENU ▼
Read by QxMD icon Read
search

PCA

keyword
https://www.readbyqxmd.com/read/29236331/reduction-of-histone-marks-h3k9me3-and-h3k27me3-by-epidrug-induces-neuroendocrine-differentiation-in-prostate-cancer
#1
Eunsohl Lee, Jingcheng Wang, Younghun Jung, Frank C Cackowski, Russell S Taichman
Neuroendocrine prostate cancer (NE PCa) is an aggressive malignancy, often presenting with advanced metastasis. We previously reported that reduction of histone marks regulated by DNMT1 following epidrug (5-Azacitidine, 5-Aza) treatment controls induction of epithelial to mesenchymal (EMT) and a cancer stem cell (CSC) phenotype, which facilitates tumorigenesis in PCa cells. Here, we use the epidrug 5-Aza as a model for how histone marks may regulate the reprogramming of prostate adenocarcinoma into NE phenotypic cells...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236307/interleukin-4-induces-a-cd44high-cd49bhigh-pc3-subpopulation-with-tumor-initiating-characteristics
#2
Holger H H Erb, Fabian Guggenberger, Frédéric R Santer, Zoran Culig
Pro- and anti-inflammatory cytokines may influence proliferation, migration, invasion and other cellular events of prostate cancer (PCa) cells. The hyaluronan receptor CD44, which is regulated by Interleukin (IL)-4, is a prostate basal cell marker. CD44high /CD49bhigh expressing cells have been demonstrated to have tumor-initiating characteristics. Here, we aimed to analyze the effects of long-term IL-4 treatment on CD44/CD49b expression, migration, proliferation and clonogenic potential of basal-like PCa cells...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236004/novel-insights-into-the-coagulation-process-for-pharmaceutical-wastewater-treatment-with-fluorescence-eems-parafac
#3
Xiying Gou, Panyue Zhang, Yonghui Song, Feng Qian, Huibing Yu, Guangming Zeng
In this study, coagulation process was applied to treat the effluent of pharmaceutical wastewater using polymeric ferric sulfate as a coagulant. Three-dimensional excitation-emission matrix fluorescence spectroscopy coupled with parallel factor analysis (EEMs-PARAFAC) was applied to investigate the fluorescent characteristics of dissolved organic matter (DOM) from pharmaceutical wastewater and the reduction of contaminant and fluorescent variations in the coagulation process. It shows that coagulation was effective to remove contaminants in the effluent of pharmaceutical wastewater, and the optimum coagulate dosage was 0...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29235993/raman-micro-spectroscopy-analysis-of-human-lens-epithelial-cells-exposed-to-a-low-dose-range-of-ionizing-radiation
#4
Christian Harry Allen, Achint Kumar, Sami Qutob, Balazs J Nyiri, Vinita Chauhan, Sangeeta Murugkar
Recent findings in populations exposed to ionizing radiation (IR) indicate dose-related lens opacification occurs at much lower doses (< 2Gy) than indicated in radiation protection guidelines. As a result, research efforts are now being directed towards identifying early predictors of lens degeneration resulting in cataractogenesis. In this study, Raman micro-spectroscopy was used to investigate the effects of varying doses of radiation, ranging from 0.01 Gy to 5 Gy, on human lens epithelial (HLE) cells which were chemically fixed 24 hrs post-irradiation...
December 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29234960/a-new-postoperative-pain-management-intravenous-acetaminophen-acelio%C3%A2-leads-to-enhanced-recovery-after-esophagectomy-a-propensity-score-matched-analysis
#5
Yu Ohkura, Junichi Shindoh, Masaki Ueno, Toshiro Iizuka, Shusuke Haruta, Harushi Udagawa
PURPOSES: To investigate the efficacy of postoperative scheduled intravenous acetaminophen to reduce the opioid use and enhance the recovery after esophagectomy. METHODS: A propensity score-matched population was created using the 93 and 69 consecutive patients who underwent esophagectomy for esophageal cancer before and after the introduction of postoperative scheduled intravenous acetaminophen, and the short-term clinical outcomes were compared. RESULTS: Significant defervescence was demonstrated in the Acetaminophen group (A-group) compared with control group (C-group) during the perioperative period (p < 0...
December 12, 2017: Surgery Today
https://www.readbyqxmd.com/read/29234421/comparative-phytochemical-profiling-and-in-vitro-antioxidant-activity-of-extracts-from-raw-materials-tissue-cultured-plants-and-callus-of-oroxylum-indicum-l-vent
#6
Piyanuch Rojsanga, Somnuk Bunsupa, Adelheid H Brantner, Pongtip Sithisarn
Extracts from raw materials from different plant parts, tissue-cultured plants, and callus cultures of Oroxylum indicum were analyzed for in vitro antioxidant activities determined by DPPH radical scavenging assay and evaluated for phytochemical profiles by TLC and LC-MS methods. The results were analyzed by principal component analysis (PCA) to evaluate the similarity. Stalk, pedicel, flower, seed, and whole fruit and callus extracts promoted strong antioxidant activity with high total phenolic and total flavonoid contents...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234392/1h-nmr-based-metabonomic-study-of-functional-dyspepsia-in-stressed-rats-treated-with-chinese-medicine-weikangning
#7
Yu Guo, Zhongfeng Li, Xinfeng Liu, Xiaolan Su, Yijie Li, Jiajie Zhu, Yilin Song, Ping Zhang, Jiande D Z Chen, Ruhan Wei, Jianqin Yang, Wei Wei
1H NMR-based metabolic profiling combined with multivariate data analysis was used to explore the metabolic phenotype of functional dyspepsia (FD) in stressed rats and evaluate the intervention effects of the Chinese medicine Weikangning (WKN). After a 7-day period of model establishment, a 14-day drug administration schedule was conducted in a WKN-treated group of rats, with the model and normal control groups serving as negative controls. Based on 1H NMR spectra of urine and serum from rats, PCA, PLS-DA, and OPLS-DA were performed to identify changing metabolic profiles...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234259/simultaneous-measurements-of-follicle-stimulating-hormone-and-total-testosterone-and-associations-in-clinically-localized-prostate-cancer
#8
Antonio B Porcaro, Salvatore Siracusano, Nicolò de Luyk, Paolo Corsi, Marco Sebben, Alessandro Tafuri, Tania Processali, Davide Inverardi, Giovanni Cacciamani, Daniele Mattevi, Maria A Cerruto, Matteo Brunelli, Claudio Ghimenton, Carmelo Monaco, Walter Artibani
Objectives: To evaluate the potential relations of simultaneous measurements of basal levels of follicle stimulating hormone (FSH) and total testosterone (TT) in clinically localized prostate cancer (PCa). Materials and Methods: The study included 126 patients who had simultaneous measurements of prostate specific antigen (PSA), FSH, and TT before undergoing radical prostatectomy for clinically localized PCa. Correlations and independent associations between clinical and pathological factors were investigated by statistical methods...
November 2017: Current Urology
https://www.readbyqxmd.com/read/29234258/toxicity-adverse-events-and-quality-of-life-associated-with-the-treatment-of-metastatic-castration-resistant-prostate-cancer
#9
REVIEW
Senol Tonyali, Hakan Bahadir Haberal, Emrullah Sogutdelen
Objectives: Among males, prostate cancer (PCa) is the most common cancer in Europe and the second most common cancer worldwide, especially in those aged > 70 years. With the advent of novel alternative treatments, survival in patients with advanced PCa has increased. PCa is now considered a chronic disease. Survival is an important endpoint in advanced PCa, as is quality of life (QoL). The effects of the disease and its treatment on patient health-related QoL must be taken into account when selecting the most appropriate treatment options...
November 2017: Current Urology
https://www.readbyqxmd.com/read/29233144/evaluation-of-serum-prolidase-activity-and-oxidative-stress-markers-in-men-with-bph-and-prostate-cancer
#10
Faruk Kucukdurmaz, Erkan Efe, Ahmet Çelik, Hasan Dagli, Metin Kılınc, Sefa Resim
BACKGROUND: Prostate cancer (PCa) and benign prostatic hyperplasia (BPH) are diseases of elderly men and are related to increased oxidative stress (OS). Although prolidase has a role in collagen metabolism, it is also used to evaluate OS in many diseases. However, there is a lack of data about serum prolidase activity (SPA) in prostate cancer. The aim of this study was to evaluate and compare SPA levels in males with BPH and PCa. METHODS: Evaluation was made of a total of 81 men who underwent transrectal ultrasound guided prostate biopsy for a definitive diagnosis due to high PSA levels...
December 12, 2017: BMC Urology
https://www.readbyqxmd.com/read/29232933/a-split-luciferase-reporter-recognizing-gfp-and-mcherry-tags-to-facilitate-studies-of-protein-protein-interactions
#11
Mehdi Moustaqil, Akshay Bhumkar, Laura Gonzalez, Lisa Raoul, Dominic J B Hunter, Pascal Carrive, Emma Sierecki, Yann Gambin
The use of fluorescently-tagged proteins in microscopy has become routine, and anti-GFP (Green fluorescent protein) affinity matrices are increasingly used in proteomics protocols. However, some protein-protein interactions assays, such as protein complementation assays (PCA), require recloning of each protein as a fusion with the different parts of the complementation system. Here we describe a generic system where the complementation is separated from the proteins and can be directly used with fluorescently-tagged proteins...
December 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29232855/magnetic-marking-and-intraoperative-detection-of-primary-draining-lymph-nodes-in-high-risk-prostate-cancer-using-superparamagnetic-iron-oxide-nanoparticles-additional-diagnostic-value
#12
Alexander Winter, Svenja Engels, Lena Reinhardt, Clara Wasylow, Holger Gerullis, Friedhelm Wawroschek
Sentinel lymph node dissection (sLND) using a magnetometer and superparamagnetic iron oxide nanoparticles (SPIONs) as a tracer was successfully applied in prostate cancer (PCa). Radioisotope-guided sLND combined with extended pelvic LND (ePLND) achieved better node removal, increasing the number of affected nodes or the detection of sentinel lymph nodes outside the established ePLND template. We determined the diagnostic value of additional magnetometer-guided sLND after intraprostatic SPION-injection in high-risk PCa...
December 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29232676/progressive-development-of-aberrant-smooth-muscle-cell-phenotype-in-abdominal-aortic-aneurysm-disease
#13
Kirsten Riches, Emily Clark, Rebecca J Helliwell, Timothy G Angelini, Karen E Hemmings, Marc A Bailey, Katherine I Bridge, D Julian A Scott, Karen E Porter
Abdominal aortic aneurysm (AAA) is a silent, progressive disease with a high mortality and an increasing prevalence with aging. Smooth muscle cell (SMC) dysfunction contributes to gradual dilatation and eventual rupture of the aorta. Here we studied phenotypic characteristics in SMC cultured from end-stage human AAA (≥5 cm) and cells cultured from a porcine carotid artery (PCA) model of early and end-stage aneurysm. Human AAA-SMC presented a secretory phenotype and expressed elevated levels of the differentiation marker miR-145 (2...
December 13, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/29232639/tracking-variations-of-fluorescent-dissolved-organic-matter-during-wastewater-treatment-by-accumulative-fluorescence-emission-spectroscopy-combined-with-principal-component-second-derivative-and-canonical-correlation-analyses
#14
Xujing Guo, Huibin Yu, Zongcheng Yan, Hongjie Gao, Yizhang Zhang
Accumulative fluorescence emission (AFE) spectroscopy combined with principal component analysis (PCA), second derivative and canonical correlation analysis (CCA) was firstly developed into an available tool to track variations in dissolved organic matter (DOM) fractions and contents during wastewater treatment. Samples were collected from a wastewater treatment plant with a traditional anaerobic/anoxic/oxic (A2O) process. The AFE spectroscopy deduced from the sum of intensities along the excitation wavelengths of fluorescence excitation emission matrix (EEM), could distinctly track tyrosine-like, tryptophan-like, fulvic-like substances...
December 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/29232594/understanding-face-familiarity
#15
Robin S S Kramer, Andrew W Young, A Mike Burton
It has been known for many years that identifying familiar faces is much easier than identifying unfamiliar faces, and that this familiar face advantage persists across a range of tasks. However, attempts to understand face familiarity have mostly used a binary contrast between 'familiar' and 'unfamiliar' faces, with no attempt to incorporate the vast range of familiarity we all experience. From family members to casual acquaintances and from personal to media exposure, familiarity is a more complex categorisation than is usually acknowledged...
December 9, 2017: Cognition
https://www.readbyqxmd.com/read/29232037/incorporating-prostate-health-index-density-mri-and-prior-negative-biopsy-status-to-improve-the-detection-of-clinically-significant-prostate-cancer
#16
Sasha C Druskin, Jeffrey J Tosoian, Allen Young, Sarah Collica, Arnav Srivastava, Kamyar Ghabili, Katarzyna J Macura, Ballentine H Carter, Alan W Partin, Lori J Sokoll, Ashley E Ross, Christian P Pavlovich
OBJECTIVES: To determine the performance of Prostate Health Index (PHI) density (PHID) combined with MRI and prior negative biopsy (PNB) status for the diagnosis of clinically-significant prostate cancer (PCa). PATIENTS & METHODS: Patients without a prior diagnosis of PCa, with elevated PSA and a normal digital rectal exam who had PHI testing prospectively prior to prostate biopsy were included. PHID was calculated retrospectively using prostate volume derived from transrectal ultrasound at biopsy...
December 12, 2017: BJU International
https://www.readbyqxmd.com/read/29231324/-effects-of-heat-reinforcing-acupuncture-on-urine-metabolites-in-rheumatoid-arthritis-rabbits
#17
Xiaozheng Du, Bo Yuan, Jinhai Wang, Xinghua Zhang, Liang Tian, Chaozhan Ren, Huazong Zeng
OBJECTIVE: To compare the effects of different acupuncture methods on urine metabolites in rheumatoid arthritis (RA) rabbits, and to explore the specificity mechanism of heat-reinforcing acupuncture for RA. METHODS: A total of 40 clean purple-blue rabbits were randomly allocated to a normal group, a model group, a mild reinforcing-reducing needling (MRRN) group, a twirling-reinforcing needling (TRN) group and a heat-reinforcing needling (HRN) group, 8 rabbits in each one...
January 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230649/investigating-monsoon-and-post-monsoon-variabilities-of-bacterioplankton-communities-in-a-mangrove-ecosystem
#18
Anwesha Ghosh, Punyasloke Bhadury
In mangrove environments, bacterioplankton communities constitute an important component of aquatic biota and play a major role in ecosystem processes. Variability of bacterioplankton communities from Sundarbans mangrove, located in the Indian subcontinent in South Asia and sits on the apex of Bay of Bengal, was investigated over monsoon and post-monsoon seasons. The study was undertaken in two stations in Sundarbans using 16S rRNA clone library and Illumina MiSeq approaches with focus on the functionally important members that participate in coastal biogeochemical cycling...
December 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29230007/elevated-preoperative-neutrophil-lymphocyte-ratio-predicts-upgrading-at-radical-prostatectomy
#19
Mehmet Özsoy, Marco Moschini, Harun Fajkovic, Francesco Soria, Christian Seitz, Tobias Klatte, Kilian Gust, Alberto Briganti, Pierre I Karakiewicz, Morgan Roupret, Gero Kramer, Shahrokh F Shariat
BACKGROUND: Neutrophil-lymphocyte ratio (NLR) is a widely used, representative marker of systemic inflammatory response within the body. NLR can be calculated from simple, inexpensive peripheral blood samples. High NLR is a negative prognostic factor in a variety of malignancies including urological tumors. In this study, we aim to assess the prognostic value of preoperative neutrophil- lymphocyte ratio (NLR) in patients treated with radical prostatectomy (RP) for localized prostate cancer (PCa)...
December 11, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29229176/use-of-concomitant-androgen-deprivation-therapy-in-patients-treated-with-early-salvage-radiotherapy-for-biochemical-recurrence-after-radical-prostatectomy-long-term-results-from-a-large-multi-institutional-series
#20
Giorgio Gandaglia, Nicola Fossati, R Jeffrey Karnes, Stephen A Boorjian, Michele Colicchia, Alberto Bossi, Thomas Seisen, Cesare Cozzarini, Nadia Di Muzio, Barbara Noris Chiorda, Emanuele Zaffuto, Thomas Wiegel, Shahrokh F Shariat, Gregor Goldner, Steven Joniau, Antonino Battaglia, Karin Haustermans, Gert De Meerleer, Valérie Fonteyne, Piet Ost, Hendrick Van Poppel, Francesco Montorsi, Alberto Briganti
BACKGROUND: Hormonal manipulation concomitant to salvage radiotherapy (SRT) given for biochemical recurrence (BCR) after radical prostatectomy (RP) improved outcomes in two randomized trials. However, neither of these studies focused on men treated at low prostate-specific antigen (PSA) levels. OBJECTIVE: To test if the impact of androgen deprivation therapy (ADT) on metastasis in patients undergoing early SRT varies according to prostate cancer (PCa) features. DESIGN, SETTING, AND PARTICIPANTS: A total of 525 patients received SRT at PSA levels ≤2ng/ml...
December 8, 2017: European Urology
keyword
keyword
22538
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"