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Principal components analysis

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https://www.readbyqxmd.com/read/28938786/prediction-of-egg-freshness-during-storage-using-electronic-nose
#1
Samuel M Yimenu, J Y Kim, B S Kim
The aim of the present study was to investigate the potential of a fast gas chromatography (GC) e-nose for freshness discrimination and for prediction of storage time as well as sensory and internal quality changes during storage of hen eggs. All samples were obtained from the same egg production farm and stored at 20 °C for 20 d. Egg sampling was conducted every 0, 3, 6, 9, 12, 16, and 20 d. During each sampling time, 4 egg cartons (each containing 10 eggs) were randomly selected: one carton for Haugh units, one carton for sensory evaluation and 2 cartons for the e-nose experiment...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28938737/complex-catsper-dependent-and-independent-ca2-i-signalling-in-human-spermatozoa-induced-by-follicular-fluid
#2
Sean G Brown, Sarah Costello, Mark C Kelly, Mythili Ramalingam, Ellen Drew, Stephen J Publicover, Christopher L R Barratt, Sarah Martins Da Silva
STUDY QUESTION: Does progesterone in human follicular fluid (hFF) activate CatSper and do other components of hFF modulate this effect and/or contribute separately to hFF-induced Ca2+ signaling? SUMMARY ANSWER: hFF potently stimulates CatSper and increases [Ca2+]i, primarily due to high concentrations of progesterone, however, other components of hFF also contribute to [Ca2+]i signaling, including modulation of CatSper channel activity and inhibition of [Ca2+]i oscillations...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938564/microrna-signatures-predict-prognosis-of-patients-with-glioblastoma-multiforme-through-the-cancer-genome-atlas
#3
Ying Yuan, Hua Zhang, Xuexia Liu, Zhongming Lu, Guojun Li, Meixia Lu, Xiaofeng Tao
MicroRNAs (miRNAs) play major roles in various biological processes and have been implicated in the pathogenesis and malignant progression of glioblastoma multiforme (GBM). The aim of this study was to assess the predictive values of miRNAs for overall survival (OS) of patients with GBM. MiRNA expression profiles and clinical information of 563 GBM patients were obtained from the Cancer Genome Atlas. The most significantly altered miRNAs were identified and miRNA expression profiles were performed, through principal component analysis, the least absolute shrinkage and selection operator method...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938072/machine-learning-for-silver-nanoparticle-electron-transfer-property-prediction
#4
Baichuan Sun, Michael Fernandez, Amanda S Barnard
Nanoparticles exhibit diverse structural and morphological features that are often inter-connected, making the correlation of structure/property relationships challenging. In this study a multi-structure/single-property relationship of silver nanoparticles is developed for the energy of Fermi level, which can be tuned to improve the transfer of electrons in a variety of applications. By combining different machine learning analytical algorithms, including k-mean, logistic regression and random forest with electronic structure simulations, we find that the degree of twinning (characterised by the fraction of hexagonal closed packed atoms) and the population of {111} facet (characterized by a surface coordination number of 9) are strongly correlated to the Fermi energy of silver nanoparticles...
September 22, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28937262/empirical-factors-affecting-the-quality-of-non-negative-matrix-factorization-of-mammalian-cell-raman-spectra
#5
H Georg Schulze, Stanislav O Konorov, James M Piret, Michael W Blades, Robin F B Turner
Mammalian cells contain various macromolecules that can be investigated non-invasively with Raman spectroscopy. The particular mixture of major macromolecules present in a cell being probed are reflected in the measured Raman spectra. Determining macromolecular identities and estimating their concentrations from these mixture Raman spectra can distinguish cell types and otherwise enable biological research. However, the application of canonical multivariate methods, such as principal component analysis (PCA), to perform spectral unmixing yields mathematical solutions that can be difficult to interpret...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28937210/multivariate-analysis-of-2d-1-h-13-c-methyl-nmr-spectra-of-monoclonal-antibody-therapeutics-to-facilitate-assessment-of-higher-order-structure
#6
Luke Arbogast, Frank Delaglio, John E Schiel, John P Marino
Two-dimensional (2D) 1H-13C methyl NMR provides a powerful tool to probe the higher order structure (HOS) of monoclonal antibodies (mAbs), since spectra can readily be acquired on intact mAbs at natural isotopic abundance, and small changes in chemical environment and structure give rise to observable changes in corresponding spectra, which can be interpreted at atomic resolution. This makes it possible to apply 2D NMR spectral fingerprinting approaches directly to drug products in order to systematically characterize structure and excipient effects...
September 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28936841/-determination-of-six-alkaloids-in-six-types-of-coptidis-rhizoma-pieces-by-rp-hplc-and-spectrum-effect-relationships-with-anti-diabetes-pharmacodynamics-data
#7
Xian-Rong Lai, Bang-Hua Zhou, Ming-Sheng Du, Hai-Jie Zheng, Zhi-Peng Geng, Jia-Chuan Li, Xian-Li Meng, Yi Zhang, Jing Zhang
To establish a method for determining the contents of six alkaloids (jatrorrhizine hydrochloride, columbamine hydrochloride, epiberberine hydrochloride, coptisine hydrochloride, palmatine hydrochloride, berberine hydrochloride) in six types of Coptidis Rhizoma pieces (crude pieces, ginger juice stir-fried pieces, vinegar stir-fried pieces, wine steamed pieces, wine stir-fried pieces, evodiae juice stir-fried pieces) by RP-HPLC, and explore the relationship with the curative effect of traditional Chinese medicine (TCM) and pharmacodynamics results...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936445/principal-components-analysis-in-clinical-studies
#8
EDITORIAL
Zhongheng Zhang, Adela Castelló
In multivariate analysis, independent variables are usually correlated to each other which can introduce multicollinearity in the regression models. One approach to solve this problem is to apply principal components analysis (PCA) over these variables. This method uses orthogonal transformation to represent sets of potentially correlated variables with principal components (PC) that are linearly uncorrelated. PCs are ordered so that the first PC has the largest possible variance and only some components are selected to represent the correlated variables...
September 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28936221/metabolite-profiling-of-barley-grains-subjected-to-water-stress-to-explain-the-genotypic-difference-in-drought-induced-impacts-on-malting-quality
#9
Xiaojian Wu, Kangfeng Cai, Guoping Zhang, Fanrong Zeng
Grain weight and protein content will be reduced and increased, respectively, when barley is subjected to water stress after anthesis, consequently deteriorating the malt quality. However, such adverse impact of water stress differs greatly among barley genotypes. In this study, two Tibetan wild barley accessions and two cultivated varieties differing in water stress tolerance were used to investigate the genotypic difference in metabolic profiles during grain-filling stage under drought condition. Totally, 71 differently accumulated metabolites were identified, including organic acids, amino acids/amines, and sugars/sugar alcohols...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28936171/neural-activity-patterns-in-the-human-brain-reflect-tactile-stickiness-perception
#10
Junsuk Kim, Jiwon Yeon, Jaekyun Ryu, Jang-Yeon Park, Soon-Cheol Chung, Sung-Phil Kim
Our previous human fMRI study found brain activations correlated with tactile stickiness perception using the uni-variate general linear model (GLM) (Yeon et al., 2017). Here, we conducted an in-depth investigation on neural correlates of sticky sensations by employing a multivoxel pattern analysis (MVPA) on the same dataset. In particular, we statistically compared multi-variate neural activities in response to the three groups of sticky stimuli: A supra-threshold group including a set of sticky stimuli that evoked vivid sticky perception; an infra-threshold group including another set of sticky stimuli that barely evoked sticky perception; and a sham group including acrylic stimuli with no physically sticky property...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28936039/comparative-three-dimensional-finite-element-analysis-of-implant-supported-fixed-complete-arch-mandibular-prostheses-in-two-materials
#11
João Paulo Mendes Tribst, Dayana Campanelli de Morais, Alexandre Abhdala Alonso, Amanda Maria de Oliveira Dal Piva, Alexandre Luis Souto Borges
BACKGROUND: The increase of requests for implant-supported prosthesis (ISP) with zirconia as infrastructure has attracted a lot of attention due to its esthetics, biocompatibility, and survival rate similar to metallic infrastructure. The aim of this study was to evaluate the influence of two different framework materials on stress distribution over a bone tissue-simulating material. MATERIALS AND METHODS: Two ISP were modeled and divided into two infrastructure materials: titanium (Ti) and zirconia...
July 2017: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/28935698/polysomnographic-phenotypes-and-their-cardiovascular-implications-in-obstructive-sleep-apnoea
#12
Andrey V Zinchuk, Sangchoon Jeon, Brian B Koo, Xiting Yan, Dawn M Bravata, Li Qin, Bernardo J Selim, Kingman P Strohl, Nancy S Redeker, John Concato, Henry K Yaggi
BACKGROUND: Obstructive sleep apnoea (OSA) is a heterogeneous disorder, and improved understanding of physiologic phenotypes and their clinical implications is needed. We aimed to determine whether routine polysomnographic data can be used to identify OSA phenotypes (clusters) and to assess the associations between the phenotypes and cardiovascular outcomes. METHODS: Cross-sectional and longitudinal analyses of a multisite, observational US Veteran (n=1247) cohort were performed...
September 21, 2017: Thorax
https://www.readbyqxmd.com/read/28935375/the-effect-of-the-origin-of-mswi-bottom-ash-on-the-h2s-elimination-from-landfill-biogas
#13
Marta Fontseré Obis, Patrick Germain, Hassan Bouzahzah, Alain Richioud, Hassen Benbelkacem
Municipal Solid Waste Incineration (MSWI) Bottom Ash (BA) is a potential alternative adsorbent for biogas treatment due to its reactivity with hydrogen sulfide (H2S). The quality of BA depends however on the nature of the waste and the process technology of the waste incineration facility. To determine whether the origin of the BA could have an influence on its H2S elimination efficiency, comparative experimental tests were conducted in a landfill site with six bottom ashes from different MSW incinerators. Results showed that one of the BAs (A) had a much higher adsorption capacity than the rest (B-F), with 37g H2S/kg dry BA, compared to 11-16g H2S/kg dry BA for the other bottom ashes...
September 18, 2017: Waste Management
https://www.readbyqxmd.com/read/28934923/discriminative-sparse-features-for-alzheimer-s-disease-diagnosis-using-multimodal-image-data
#14
A Ortiz, F Lozano, J M Gorriz, J Ramírez, F J Martinez-Murci, For The Alzheimer S Disease Neuroimaging Initiative
BACKGROUND: Feature extraction in medical image processing still remains a challenge, especially in high-dimensionality datasets, where the expected number of available samples is considerably lower than the dimension of the feature space. This is a common problem in real-world data, and, specifically, in medical image pro- cessing as, while images are composed of hundreds of thousands voxels, only a reduced number of patients are available. OBJECTIVE: Extracting descriptive and discriminative features to represent each sample (image) by a small number of features, which is particularly important in classification task, due to the curse of dimensionality problem...
September 21, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28934330/an-analysis-of-beak-shape-variation-in-two-ages-of-domestic-turkeys-meleagris-gallopavo-using-landmark-based-geometric-morphometrics
#15
Hillary A Dalton, Benjamin J Wood, Tina M Widowski, Michele T Guerin, Stephanie Torrey
The objective of this study was to assess beak shape variation in domestic turkeys (Meleagris gallopavo) and determine the effects of age, sex, and beak size on beak shape variation using geometric morphometrics. Dorsal and right lateral images were taken of 2442 turkeys at 6 and 18.5 weeks of age. Landmarks were digitized in tpsDig in three analyses of the dorsal upper mandible, lateral upper mandible, and lateral lower mandible shape of each turkey at both ages. The coordinate data were then subjected to a principal components analysis (PCA), multivariate regression, and a canonical variates analysis (CVA) with a Procrustes ANOVA in MorphoJ...
2017: PloS One
https://www.readbyqxmd.com/read/28934231/principal-component-analysis-identifies-patterns-of-cytokine-expression-in-non-small-cell-lung-cancer-patients-undergoing-definitive-radiation-therapy
#16
Susannah G Ellsworth, Bryan M Rabatic, Jie Chen, Jing Zhao, Jeffrey Campbell, Weili Wang, Wenhu Pi, Paul Stanton, Martha Matuszak, Shruti Jolly, Amy Miller, Feng-Ming Kong
BACKGROUND/PURPOSE: Radiation treatment (RT) stimulates the release of many immunohumoral factors, complicating the identification of clinically significant cytokine expression patterns. This study used principal component analysis (PCA) to analyze cytokines in non-small cell lung cancer (NSCLC) patients undergoing RT and explore differences in changes after hypofractionated stereotactic body radiation therapy (SBRT) and conventionally fractionated RT (CFRT) without or with chemotherapy...
2017: PloS One
https://www.readbyqxmd.com/read/28934162/gas-chromatography-mass-spectrometry-for-metabolite-profiling-of-japanese-black-cattle-naturally-contaminated-with-zearalenone-and-sterigmatocystin
#17
Katsuki Toda, Emiko Kokushi, Seiichi Uno, Ayaka Shiiba, Hiroshi Hasunuma, Yasuo Fushimi, Missaka P B Wijayagunawardane, Chunhua Zhang, Osamu Yamato, Masayasu Taniguchi, Johanna Fink-Gremmels, Mitsuhiro Takagi
The objective of this study was to evaluate the metabolic profile of cattle fed with or without zearalenone (ZEN) and sterigmatocystin (STC)-contaminated diets using a gas chromatography-mass spectrometry metabolomics approach. Urinary samples were collected from individual animals (n = 6 per herd) from fattening female Japanese Black (JB) cattle herds (23 months old, 550-600 kg). Herd 1 had persistently high urinary ZEN and STC concentrations due to the presence of contaminated rice straw. Herd 2, the second female JB fattening herd (23 months old, 550-600 kg), received the same dietary feed as Herd 1, with non-contaminated rice straw...
September 21, 2017: Toxins
https://www.readbyqxmd.com/read/28933794/inhibitory-profiles-of-spices-against-free-and-protein-bound-heterocyclic-amines-of-roast-beef-patties-as-revealed-by-ultra-performance-liquid-chromatography-tandem-mass-spectrometry-and-principal-component-analysis
#18
Jing Chen, Zhiyong He, Fang Qin, Jie Chen, Dongsheng Cao, Fengxian Guo, Maomao Zeng
The effects of various levels of chili pepper, Sichuan pepper, and black pepper on the amounts of 17 heterocyclic amines (HAs) from seven categories of both free and protein-bound states in roast beef patties were assessed by ultra-performance liquid chromatography-tandem mass spectrometry combined with principal component analysis. Three groups of HA, including imidazopyridines (DMIP), imidazoquinoxalines (MeIQx and 4,8-MeIQx), and β-carbolines (norharman and harman), were detected and quantified in both their free and protein-bound states, whereas PhIP was detected only in its free state, and imidazoquinolines (IQ, IQ[4,5-b], and MeIQ), α-carbolines (AαC and MeAαC), and phenylpyridines (Phe-P-1) were detected only in their protein-bound states...
September 21, 2017: Food & Function
https://www.readbyqxmd.com/read/28933707/high-accuracy-automatic-classification-of-parkinsonian-tremor-severity-using-machine-learning-method
#19
Hyoseon Jeon, Woongwoo Lee, Hyeyoung Park, Hong Ji Lee, Sang Kyong Kim, Han Byul Kim, Beomseok Jeon, Kwang Suk Park
Although clinical aspirations for new technology to accurately measure and diagnose Parkinsonian tremors exist, automatic scoring of tremor severity using machine learning approaches has not yet been employed. Objective: This study aims to maximize the scientific validity of automatic tremor-severity classification using machine learning algorithms to score Parkinsonian tremor severity in the same manner as the Unified Parkinson's Disease Rating Scale (UPDRS) used to rate scores in real clinical practice...
September 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28932981/the-spatial-distribution-and-accumulation-characteristics-of-heavy-metals-in-steppe-soils-around-three-mining-areas-in-xilinhot-in-inner-mongolia-china
#20
Yongfei Gao, Honglin Liu, Guixiang Liu
Metal deposition has become a major environmental problem in China due to its adverse effects on human and ecosystem health, particularly in Inner Mongolia, where frequent dust storms (due to steppe degradation and desertification) and soil pollution (associated with the increasing mining activities) have occurred in recent decades. To assess spatial distribution of heavy metals and the influences of mining activities on geochemical behavior of heavy metals in soils, soil samples with depth of 0-10, 10-20, and 20-30 cm at each site were collected from different directions in the vicinity of three mines (coal mine, gold mine, and fluorite mine) in a typical steppe zone of Inner Mongolia, China...
September 20, 2017: Environmental Science and Pollution Research International
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