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https://www.readbyqxmd.com/read/27146676/cost-effectiveness-of-different-forms-of-intra-articular-injections-for-the-treatment-of-osteoarthritis-of-the-knee
#1
Jeffrey Rosen, Parag Sancheti, Anke Fierlinger, Faizan Niazi, Herman Johal, Asheesh Bedi
INTRODUCTION: Osteoarthritis (OA), as one of the leading causes of disability, decreases the quality of life for those suffering from the disease and creates a substantial financial burden. Intra-articular hyaluronic acid (HA) can provide relief from the symptoms of OA and multiple HA products are prescribed. The purpose of this study is to examine the single payer cost-effectiveness of various HA products in the treatment of knee OA. METHODS: A single payer economic evaluation was conducted comparing Synvisc(®) (Sanofi, USA), Durolane(®) (Bioventus, USA), Hyalgan(®) (Fidia Pharma Inc...
June 2016: Advances in Therapy
https://www.readbyqxmd.com/read/25889322/comparison-of-two-hyaluronic-acid-formulations-for-safety-and-efficacy-chase-study-in-knee-osteoarthritis-a-multicenter-randomized-double-blind-26-week-non-inferiority-trial-comparing-durolane-to-artz
#2
RANDOMIZED CONTROLLED TRIAL
Heng Zhang, Ke Zhang, Xianlong Zhang, Zhenan Zhu, Shigui Yan, Tiansheng Sun, Ai Guo, John Jones, R Grant Steen, Bin Shan, Jenny Zhang, Jianhao Lin
INTRODUCTION: Intra-articular injection of hyaluronic acid (HA) is often used as therapy for knee osteoarthritis because it is less expensive and less aggressive than total knee replacement. Therefore, it is important to document whether HA is safe and efficacious. We tested whether single and multiple injection viscosupplementation with HA is associated with clinically meaningful pain relief in a new randomized clinical trial (RCT). Our objective was to compare safety and efficacy of intra-articular HA in two formulations: one 3...
2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/25776637/comparison-of-two-hyaluronic-acid-formulations-for-safety-and-efficacy-chase-study-in-knee-osteoarthritis-a-multicenter-randomized-double-blind-26-week-non-inferiority-trial-comparing-durolane%C3%A2-to-artz%C3%A2
#3
Heng Zhang, Ke Zhang, Xianlong Zhang, Zhenan Zhu, Shigui Yan, Tiansheng Sun, Ai Guo, John Jones, R Grant Steen, Bin Shan, Jenny Zhang, Jianhao Lin
INTRODUCTION: Intra-articular injection of hyaluronic acid (HA) is often used as therapy for knee osteoarthritis because it is less expensive and less aggressive than total knee replacement. Therefore, it is important to document whether HA is safe and efficacious. We tested whether single and multiple injection viscosupplementation with HA is associated with clinically meaningful pain relief in a new randomized clinical trial (RCT). Our objective was to compare safety and efficacy of intra-articular HA in two formulations: one 3...
December 2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/24185114/nasha-hyaluronic-acid-vs-methylprednisolone-for-knee-osteoarthritis-a-prospective-multi-centre-randomized-non-inferiority-trial
#4
RANDOMIZED CONTROLLED TRIAL
R Leighton, C Akermark, R Therrien, J B Richardson, M Andersson, M G Todman, N K Arden
OBJECTIVE: To compare NASHA hyaluronic acid gel as single-injection intra-articular (IA) treatment for knee osteoarthritis (OA) against methylprednisolone acetate (MPA). DESIGN: This was a prospective, multi-centre, randomized, active-controlled, double-blind, non-inferiority clinical trial. A unique, open-label extension phase (OLE) was undertaken to answer further important clinical questions. Subjects with painful unilateral knee OA were treated and followed for 26 weeks (blinded phase)...
January 2014: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/24075613/comparison-of-intra-articular-injections-of-plasma-rich-in-growth-factors-prgf-endoret-versus-durolane-hyaluronic-acid-in-the-treatment-of-patients-with-symptomatic-osteoarthritis-a-randomized-controlled-trial
#5
RANDOMIZED CONTROLLED TRIAL
Víctor Vaquerizo, Miguel Ángel Plasencia, Ignacio Arribas, Roberto Seijas, Sabino Padilla, Gorka Orive, Eduardo Anitua
PURPOSE: The purpose of this study was to compare the efficacy and safety in a randomized, clinical trial of 3 injections of PRGF-Endoret (BTI Biotechnology Institute, Vitoria, Spain) versus one single intra-articular injection of Durolane hyaluronic acid (HA) (Q-MED AB, Uppsala, Sweden) as a treatment for reducing symptoms in patients with knee osteoarthritis (OA). METHODS: Ninety-six patients with symptomatic knee OA were randomly assigned to receive PRGF-Endoret (3 injections on a weekly basis) or one infiltration with Durolane HA...
October 2013: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/22072598/investigation-of-different-cell-types-and-gel-carriers-for-cell-based-intervertebral-disc-therapy-in-vitro-and-in-vivo-studies
#6
H B Henriksson, M Hagman, M Horn, A Lindahl, H Brisby
Biological treatment options for the repair of intervertebral disc damage have been suggested for patients with chronic low back pain. The aim of this study was to investigate possible cell types and gel carriers for use in the regenerative treatment of degenerative intervertebral discs (IVD). In vitro: human mesenchymal cells (hMSCs), IVD cells (hDCs), and chondrocytes (hCs) were cultivated in three gel types: hyaluronan gel (Durolane®), hydrogel (Puramatrix®), and tissue-glue gel (TISSEEL®) in chondrogenic differentiation media for 9 days...
October 2012: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/21068096/efficacy-of-a-single-ultrasound-guided-injection-for-the-treatment-of-hip-osteoarthritis
#7
RANDOMIZED CONTROLLED TRIAL
Ismaël Atchia, David Kane, Mike R Reed, John D Isaacs, Fraser Birrell
BACKGROUND: Intra-articular injection is effective for osteoarthritis, but the best single injection strategy is not known, nor are there established predictors of response. The objectives of this study were to assess and predict response to a single ultrasound-guided injection in moderate to severe hip osteoarthritis. METHODS: 77 hip osteoarthritis patients entered a prospective, randomised controlled trial, randomised to one of four groups: standard care (no injection); normal saline; non-animal stabilised hyaluronic acid (durolane) or methylprednisolone acetate (depomedrone)...
January 2011: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/17874246/what-is-the-evidence-for-viscosupplementation-in-the-treatment-of-patients-with-hip-osteoarthritis-systematic-review-of-the-literature
#8
REVIEW
Michel P J van den Bekerom, Bas Lamme, An Sermon, Michiel Mulier
INTRODUCTION: Osteoarthritis (OA) is a disease of the synovial joints and is the most common cause of chronic pain in the elderly. One of the treatment modalities for OA of the hip is viscosupplementation (VS). Today there are several different formulations of viscosupplements produced by different manufactures of different molecular weights. The objective of this review is to asses the efficacy of VS treatment of hip OA osteoarthritis in the current literature. MATERIAL AND METHODS: The following databases were searched: Medline (period 1966 to November 2006), Cochrane Database of Systematic Reviews (1988 to November 2006), Cochrane Clinical Trial Register (1988 to November 2006), Database of Abstracts on Reviews and Effectiveness, Current Controlled Trials, National Research Register and Embase (January 1988 to November 2006)...
August 2008: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/16794845/-reduction-of-arthrosis-associated-knee-pain-through-a-single-intra-articular-injection-of-synthetic-hyaluronic-acid
#9
D Krocker, G Matziolis, J Tuischer, J Funk, S Tohtz, F Buttgereit, C Perka
AIM: Conventional hyaluronic acids need three to five injections for therapeutic success, whereas Durolane), a synthetic hyaluronic acid, needs only a single injection. Clinical outcome using Durolane should be compared with the results of studies using hyaluronic acids or glucocorticoids. METHOD: Fifty patients with primary gonarthrosis stages I-III (Kellgren Score) were investigated for knee function, pain intensity, and quality of life. The knee and osteoarthritis outcome score (KOOS), visual analogue scale (VAS), and European quality of live score (EQ-5D), as well as motion of the knee were measured...
July 2006: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/16625635/viscosupplementation-for-the-treatment-of-osteoarthritis-of-the-knee
#10
REVIEW
N Bellamy, J Campbell, V Robinson, T Gee, R Bourne, G Wells
BACKGROUND: Osteoarthritis (OA) is the most prevalent chronic joint disorder worldwide and is associated with significant pain and disability. OBJECTIVES: To assess the effects of viscosupplementation in the treatment of OA of the knee. The products were hyaluronan and hylan derivatives (Adant, Arthrum H, Artz (Artzal, Supartz), BioHy (Arthrease, Euflexxa, Nuflexxa), Durolane, Fermathron, Go-On, Hyalgan, Hylan G-F 20 (Synvisc Hylan G-F 20), Hyruan, NRD-101 (Suvenyl), Orthovisc, Ostenil, Replasyn, SLM-10, Suplasyn, Synject and Zeel compositum)...
2006: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/15846754/viscosupplementation-for-the-treatment-of-osteoarthritis-of-the-knee
#11
REVIEW
N Bellamy, J Campbell, V Robinson, T Gee, R Bourne, G Wells
BACKGROUND: Osteoarthritis (OA) is the most prevalent chronic joint disorder worldwide and is associated with significant pain and disability. OBJECTIVES: To assess the effects of viscosupplementation in the treatment of OA of the knee. The products were hyaluronan and hylan derivatives (Adant, Arthrum H, Artz (Artzal, Supartz), BioHy (Arthrease), Durolane, Fermathron, Go-On, Hyalgan, Hylan G-F 20 (Synvisc Hylan G-F 20), NRD-101, Orthovisc, Ostenil, Replasyn, SLM-10, Suplasyn, Synject and Zeel compositum)...
April 18, 2005: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/15262244/efficacy-and-safety-of-a-single-intra-articular-injection-of-non-animal-stabilized-hyaluronic-acid-nasha-in-patients-with-osteoarthritis-of-the-knee
#12
RANDOMIZED CONTROLLED TRIAL
Roy D Altman, Christian Akermark, André D Beaulieu, Thomas Schnitzer
OBJECTIVE: Non-animal stabilized hyaluronic acid (NASHA) is a novel hyaluronan (HA) preparation with a 4-week intra-articular half-life. This study compared the efficacy of a single injection of NASHA with placebo in patients with osteoarthritis (OA) of the knee. DESIGN: This was a 26-week randomized, double-blind, multicenter study of a single intra-articular knee injection with either NASHA or placebo (saline). Assessments included the Western Ontario McMasters Universities osteoarthritis index (WOMAC, Likert Scale) and patients' overall global disease status...
August 2004: Osteoarthritis and Cartilage
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