Javier Ruiz Luque, Ágata Carolina Cevey, Azul Victoria Pieralisi, Carolina Poncini, Fernando Erra Díaz, Marcus Vinicius Azevedo Reis, Martin Donato, Gerardo Ariel Mirkin, Nora Beatriz Goren, Federico Nicolás Penas
Chagas disease, caused by Trypanosoma cruzi , stands as the primary cause of dilated cardiomyopathy in the Americas. Macrophages play a crucial role in the heart's response to infection. Given their functional and phenotypic adaptability, manipulating specific macrophage subsets could be vital in aiding essential cardiovascular functions including tissue repair and defense against infection. PPARα are ligand-dependent transcription factors involved in lipid metabolism and inflammation regulation. However, the role of fenofibrate, a PPARα ligand, in the activation profile of cardiac macrophages as well as its effect on the early inflammatory and fibrotic response in the heart remains unexplored...
April 22, 2024: ACS Infectious Diseases