keyword
https://read.qxmd.com/read/38412276/drugs-for-menopausal-symptoms
#1
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 4, 2024: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/38133585/drugs-for-depressionr
#2
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
December 11, 2023: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/37516898/drugs-for-anxiety-disorders
#3
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
August 7, 2023: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/37339089/brexpiprazole-rexulti-for-agitation-in-alzheimer-s-dementia
#4
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
June 26, 2023: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/35736504/ssri-antidepressants-differentially-modulate-serotonin-reuptake-and-release-in-drosophila
#5
JOURNAL ARTICLE
Kelly E Dunham, B Jill Venton
Selective serotonin reuptake inhibitor (SSRI) antidepressants are commonly prescribed treatments for depression, but their effects on serotonin reuptake and release are not well understood. Drosophila melanogaster, the fruit fly, expresses the serotonin transporter (dSERT), the major target of SSRIs, but real-time serotonin changes after SSRIs have not been characterized in this model. The goal of this study was to characterize effects of SSRIs on serotonin concentration and reuptake in Drosophila larvae. We applied various doses (0...
September 2022: Journal of Neurochemistry
https://read.qxmd.com/read/35475053/abnormal-uterine-bleed-in-a-postmenopausal-woman-with-the-use-of-escitalopram
#6
Akshita Yadav, Brandon S Bharat, Stephanie Montrose
Selective serotonin reuptake inhibitors (SSRIs) are among the most widely used antidepressants worldwide. They are an effective first-line treatment for depression. Common side effects can be quickly remediated by switching to a different drug, making it easy to miss rare side effects and even causing them to go underreported. This case study examines an instance of uterine bleeding in a postmenopausal woman after starting an antidepressant. A detailed history determined that the medication was the only noticeable change in her daily routine before the onset of bleeding, making it the likely cause...
March 2022: Curēus
https://read.qxmd.com/read/33779577/the-efficacy-of-escitalopram-in-major-depressive-disorder-a-multicenter-randomized-placebo-controlled-double-blind-study
#7
RANDOMIZED CONTROLLED TRIAL
Xiaoliang Wang, Yimin Fan, Guanjun Li, Huafang Li
The aim of the study was to conduct a multicenter randomized double-blinded placebo-controlled clinical study to evaluate the efficacy of a generic form of escitalopram in treating major depressive disorder (MDD). A total of 390 MDD patients admitted to hospitals in six cities in China were randomized to receive the generic version of escitalopram, the proprietary form of escitalopram (Lexapro) or placebo. During the 8-week treatment, the Hamilton rating scale for depression-17 (HAM-D17), Hamilton Anxiety Rating Scale (HAMA), Montgomery-Åsberg Depression Rating Scale (MADRS), Clinical Global Impressions scale (CGI), current visual analogue scale pain levels (VAS-P1) and Sheehan Disability Scale (SDS) assessments were performed at week 0, 1, 2, 4, 6 and 8 to evaluate treatment responses...
May 1, 2021: International Clinical Psychopharmacology
https://read.qxmd.com/read/33262577/comparison-of-bioavailability-and-bioequivalence-of-generic-and-brand-name-formulations-of-escitalopram-oxalate-tablets-in-healthy-chinese-population-under-fasting-and-fed-conditions
#8
RANDOMIZED CONTROLLED TRIAL
Qiuying Li, Hua Huo, Wenli Hu, Yin Sui, Yunbiao Tang
PURPOSE: This study compared the bioequivalence of two formulations of escitalopram oxalate 20 mg tablets in terms of bioavailability and tolerability in healthy Chinese male and female subjects. PATIENTS AND METHODS: A randomized, single-blind, two-period, two-sequence crossover study was performed under fasting and fed conditions, with a 21-day washout period. In total, 24 healthy subjects (18 males and 6 females) were enrolled in the fasting test and the fed test, respectively...
2020: Drug Design, Development and Therapy
https://read.qxmd.com/read/32077266/the-teratogenic-effects-of-sertraline-in-mice
#9
JOURNAL ARTICLE
Robert M Cabrera, Ying Linda Lin, Elizabeth Law, Jimi Kim, Bogdan J Wlodarczyk
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs), which include paroxetine (Paxil), sertraline (Zoloft), fluoxetine (Prozac), citalopram (Celexa), and escitalopram (Lexapro), are the most common antidepressants prescribed to pregnant women. There is considerable debate in the literature regarding the developmental toxicities of SSRIs individually, and as a class. METHODS: It is considered unethical to perform developmental toxicity studies on pregnant women, but rodent and nonrodent species provide laboratory-controlled experimental models to examine the toxicity of SSRI exposure during pregnancy...
August 2020: Birth Defects Research
https://read.qxmd.com/read/31917736/when-to-raise-our-white-flag-a-discussion-of-scope-of-practice-in-a-resource-scarce-world
#10
JOURNAL ARTICLE
Elizabeth Barnhardt, Rebecca Baum, Mark Winerman, Pankhuree Vandana, Karen B Tabern, Marilyn Augustyn
Thomas is a 13-year-old boy with autism spectrum disorder, attention deficit hyperactivity disorder (ADHD), generalized anxiety disorder, separation anxiety disorder, and major depressive disorder who presented for a follow-up to his developmental and behavioral pediatrician (DBP). His mother describes an increase in symptoms of anxiety and depression for the last 6 weeks, accompanied by suicidal ideation and thoughts of self-mutilation.Before this increase in symptoms, he had been doing well for the last several months with the exception of increasing weight gain, and Abilify was decreased from 5 mg to 2...
2020: Journal of Developmental and Behavioral Pediatrics: JDBP
https://read.qxmd.com/read/31065579/the-psytar-dataset-from-patients-generated-narratives-to-a-corpus-of-adverse-drug-events-and-effectiveness-of-psychiatric-medications
#11
JOURNAL ARTICLE
Maryam Zolnoori, Kin Wah Fung, Timothy B Patrick, Paul Fontelo, Hadi Kharrazi, Anthony Faiola, Nilay D Shah, Yi Shuan Shirley Wu, Christina E Eldredge, Jake Luo, Mike Conway, Jiaxi Zhu, Soo Kyung Park, Kelly Xu, Hamideh Moayyed
The "Psychiatric Treatment Adverse Reactions" (PsyTAR) dataset contains patients' expression of effectiveness and adverse drug events associated with psychiatric medications. The PsyTAR was generated in four phases. In the first phase, a sample of 891 drugs reviews posted by patients on an online healthcare forum, "askapatient.com", was collected for four psychiatric drugs: Zoloft, Lexapro, Cymbalta, and Effexor XR. For each drug review, patient demographic information, duration of treatment, and satisfaction with the drugs were reported...
June 2019: Data in Brief
https://read.qxmd.com/read/30407100/selective-serotonin-reuptake-inhibitors-and-persistent-pulmonary-hypertension-of-the-newborn-an-update-meta-analysis
#12
REVIEW
Qin Xiang Ng, Nandini Venkatanarayanan, Collin Yih Xian Ho, Wen Shan Sim, Donovan Yutong Lim, Wee-Song Yeo
BACKGROUND: Persistent pulmonary hypertension of the newborn (PPHN) is a serious condition associated with substantial mortality and morbidity. Previous studies have suggested a possible link between maternal selective serotonin reuptake inhibitor (SSRI) use and the risk of PPHN. This study aimed to provide an up-to-date review and meta-analysis of the topic. METHODS: Using the search terms [SSRI OR SSRIs OR selective serotonin reuptake inhibitors OR antidepressant OR Prozac OR fluoxetine OR Lexapro OR escitalopram] AND [pregnancy OR maternal OR newborn OR persistent pulmonary hypertension OR PPHN OR neonat* OR fet*], a preliminary search on the PubMed, Medline, EMBASE, Web of Science, and Google Scholar database yielded 7327 articles published in English between January 1, 1960 and October 1, 2017...
March 2019: Journal of Women's Health
https://read.qxmd.com/read/30287417/identifying-the-underlying-factors-associated-with-patients-attitudes-toward-antidepressants-qualitative-and-quantitative-analysis-of-patient-drug-reviews
#13
JOURNAL ARTICLE
Maryam Zolnoori, Kin Wah Fung, Paul Fontelo, Hadi Kharrazi, Anthony Faiola, Yi Shuan Shirley Wu, Virginia Stoffel, Timothy Patrick
BACKGROUND: Nonadherence to antidepressants is a major obstacle to deriving antidepressants' therapeutic benefits, resulting in significant burdens on the individuals and the health care system. Several studies have shown that nonadherence is weakly associated with personal and clinical variables but strongly associated with patients' beliefs and attitudes toward medications. Patients' drug review posts in online health care communities might provide a significant insight into patients' attitude toward antidepressants and could be used to address the challenges of self-report methods such as patients' recruitment...
September 30, 2018: JMIR Mental Health
https://read.qxmd.com/read/29381782/pathway-of-maternal-serotonin-to-the-human-embryo-and-fetus
#14
JOURNAL ARTICLE
Harvey J Kliman, Sarah B Quaratella, Alessandra C Setaro, Erin C Siegman, Zarrin T Subha, Reshef Tal, Kristin M Milano, Theodore L Steck
Serotonin [5-hydroxytryptamine (5-HT)] is essential to intrauterine development, but its source is debated. We used immunocytochemistry to gauge 5-HT, its biosynthetic enzyme tryptophan hydroxylase 1 (TPH1); an importer (serotonin transporter, 5-HTT/SERT/SLC6A); other transporters [P-glycoprotein 1 (P-gp/ABCB1), OCT3/SLC22A3, and gap junction connexin-43]; and the 5-HT degradative enzyme monoamine oxidase A (MAOA) in sections of placentas. In humans, 5-HT was faintly stained only in first-trimester trophoblasts, whereas TPH1 was not seen at any stage...
April 1, 2018: Endocrinology
https://read.qxmd.com/read/28649145/do-ssris-and-snris-reduce-the-frequency-and-or-severity-of-hot-flashes-in-menopausal-women
#15
REVIEW
Chris Stubbs, Lisa Mattingly, Steven A Crawford, Elizabeth A Wickersham, Jessica L Brockhaus, Laine H McCarthy
CLINICAL QUESTION: In menopausal women who experience regular hot flashes, does treatment with selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) reduce the frequency and/or severity of hot flashes? ANSWER: Yes. Review of the literature suggests that treatment with SSRIs or SNRIs reduces the frequency and severity of hot flashes in menopausal and post-menopausal women. Studies demonstrated that paroxetine (Paxil), citalopram (Celexa) and escitolapram (Lexapro) were the most effective SSRIs, and venlafaxine (Effexor) was the most effective first line SNRI, with desvenlafaxine as a second option...
May 2017: Journal of the Oklahoma State Medical Association
https://read.qxmd.com/read/27822048/analysis-of-treatment-patterns-and-persistence-on-branded-and-generic-medications-in-major-depressive-disorder-using-retrospective-claims-data
#16
JOURNAL ARTICLE
Caitlyn T Solem, Ahmed Shelbaya, Yin Wan, Chinmay G Deshpande, Jose Alvir, Elizabeth Pappadopulos
BACKGROUND: In major depressive disorder (MDD), treatment persistence is critical to optimize symptom remission, functional recovery, and health care costs. Desvenlafaxine tends to have fewer drug interactions and better tolerability than other MDD drugs; however, its use has not been assessed in the real world. OBJECTIVE: The aim of the present study is to compare medication persistence and concomitant MDD drug use with branded desvenlafaxine (Pristiq® ) compared with antidepressant drug groups classified as 1) branded selective serotonin reuptake inhibitors (SSRIs; ie, escitalopram [Lexapro™]) and selective serotonin-norepinephrine reuptake inhibitors (SNRIs; ie, venlafaxine [Effexor® ], duloxetine [Cymbalta® ]) and 2) generic SSRIs/SNRIs (ie, escitalopram, citalopram, venlafaxine, fluvoxamine, fluoxetine, sertraline, paroxetine, and duloxetine)...
2016: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/27176755/the-citalopram-cit-md-18-pediatric-depression-trial-deconstruction-of-medical-ghostwriting-data-mischaracterisation-and-academic-malfeasance
#17
JOURNAL ARTICLE
Jon N Jureidini, Jay D Amsterdam, Leemon B McHenry
OBJECTIVE: Deconstruction of a ghostwritten report of a randomized, double-blind, placebo-controlled efficacy and safety trial of citalopram in depressed children and adolescents conducted in the United States. METHODS: Approximately 750 documents from the Celexa and Lexapro Marketing and Sales Practices Litigation: Master Docket 09-MD-2067-(NMG) were deconstructed. RESULTS: The published article contained efficacy and safety data inconsistent with the protocol criteria...
March 16, 2016: International Journal of Risk & Safety in Medicine
https://read.qxmd.com/read/25970510/decreased-escitalopram-concentrations-post-roux-en-y-gastric-bypass-surgery
#18
JOURNAL ARTICLE
Mark A Marzinke, Athena K Petrides, Kimberley Steele, Michael A Schweitzer, Thomas H Magnuson, Shauna P Reinblatt, Janelle W Coughlin, William Clarke
BACKGROUND: There is a high coincidence between obesity and psychiatric disorders including depression. Depressive disorders are commonly treated with antidepressants, including the selective serotonin reuptake inhibitor Lexapro (escitalopram). Although candidates for elective Roux-en-Y gastric bypass (RYGB) surgery may be treated with escitalopram, drug dosing strategies are typically not adjusted postoperatively. Therefore, studies are needed to better characterize escitalopram drug concentrations in a postsurgical setting...
June 2015: Therapeutic Drug Monitoring
https://read.qxmd.com/read/25523893/perinatal-vs-genetic-programming-of-serotonin-states-associated-with-anxiety
#19
JOURNAL ARTICLE
Stefanie C Altieri, Hongyan Yang, Hannah J O'Brien, Hannah M Redwine, Damla Senturk, Julie G Hensler, Anne M Andrews
Large numbers of women undergo antidepressant treatment during pregnancy; however, long-term consequences for their offspring remain largely unknown. Rodents exposed to serotonin transporter (SERT)-inhibiting antidepressants during development show changes in adult emotion-like behavior. These changes have been equated with behavioral alterations arising from genetic reductions in SERT. Both models are highly relevant to humans yet they vary in their time frames of SERT disruption. We find that anxiety-related behavior and, importantly, underlying serotonin neurotransmission diverge between the two models...
May 2015: Neuropsychopharmacology
https://read.qxmd.com/read/24991142/efficacy-and-safety-of-generic-escitalopram-versus-lexapro-in-the-treatment-of-major-depression-a-multicenter-double-blinded-randomized-controlled-trial
#20
JOURNAL ARTICLE
Yimin Yu, Huafang Li, Biao Wang, Keqing Li, Xiufeng Xu, Jianguo Shi, Chengge Gao, Qingrong Tan
BACKGROUND: Depression is an increasingly important public health problem in China, but only a small minority of patients with this condition receive treatment. One of the reasons for low treatment rates is the relatively high cost of imported antidepressant medications. AIM: Compare the efficacy and safety of the generic form of the selective serotonin re-uptake inhibitory (SSRI) antidepressant escitalopram to the proprietary form of escitalopram (Lexapro) in the treatment of major depression...
April 2013: Shanghai Archives of Psychiatry
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