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Cutaneous lichen planus

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https://www.readbyqxmd.com/read/29330580/-lichen-ruber-planus-better-understanding-better-treatment
#1
REVIEW
L Schilling, T Vogt
Lichen ruber, also called lichen ruber planus or lichen planus (LP), is a noncontagious inflammatory skin disease. LP is the main representative and namesake of the group of lichenoid diseases, which are characterized by small papules often accompanied by severe itching. With 65% of cases, LP is primarily a disease of the mucous membranes. In 20% of the cases, the disease is found on the skin and mucous membranes; skin involvement alone is seen in only about 10% of cases. Cutaneous LP has a very favorable 1‑year prognosis of almost 80% healing as opposed to the mucosa and the adnexal organs...
January 12, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29241755/autoimmune-skin-diseases-and-the-metabolic-syndrome
#2
Begüm Ünlü, Ümit Türsen
The metabolic syndrome represents an important association of cutaneous maladies with cardiovascular illnesses. Chronic inflammation, shared risk factors (ie, smoking and alcohol consumption), treatment (ie, immunosuppressive agents and drugs that alter the lipid profile), and shared genetic risk loci have been proposed to the cause metabolic syndrome and cardiovascular morbidity of autoimmune diseases. There are many possible inflammatory mediators that are suggested to play a role in insulin resistance pathogenesis, such as tumor necrosis factor-α, interleukin-6, leptin, and adiponectin...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29214109/a-solitary-pink-lesion-dermoscopy-and-rcm-features-of-lichen-planus
#3
Claudia Pezzini, Simonetta Piana, Caterina Longo, Elisa Benati, Stefania Borsari, Francesca Specchio, Elvira Moscarella
We present an unusual onset of cutaneous lichen planus (LP) in a middle-aged patient. The initial presentation as solitary, indolent pink lesion required further investigations to rule out malignancy, especially amelanotic melanoma. Dermoscopy and reflectance confocal microscopy findings were found to be helpful in our case in addressing the correct diagnosis.
October 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29180319/wolf-s-isotopic-response-lichen-planus-patterns-on-non-segmental-muco-cutaneous-vitiligo
#4
Ali Alamri, Adel Alsenaid, Thomas Ruzicka, Ronald Wolf
No abstract text is available yet for this article.
November 28, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29170187/the-rare-occurrence-of-cutaneous-and-mucosal-lichen-planus-in-hiv-infection
#5
Preet Mukesh Shah, Vijay Waman Dhakre
No abstract text is available yet for this article.
November 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29144206/c-jun-expression-in-lichen-planus-psoriasis-and-cutaneous-squamous-cell-carcinoma-an-immunohistochemical-study
#6
Asmaa Gaber Abdou, Alaa Hassan Marae, Mohammed Shoeib, Ghada Dawood, Enas Abouelfath
The AP-1 transcription factor complex is a key player in regulating inflammatory processes, cell proliferation, differentiation and cell transformation. The aim of the present study is to investigate C-Jun (one of AP-1complex) expression and its proliferative role in skin samples of lichen planus, psoriasis as common inflammatory skin diseases and squamous cell carcinoma using immunohistochemical method. The present study was carried out on skin biopsies of 15 psoriatic patients, 15 lichen planus patients, 15 SCC and 15 normal skin biopsies...
November 16, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/29139037/prevalence-of-oral-lichen-planus-in-iranian-children-and-adolescents-a-12-year-retrospective-study
#7
S Bakhtiari, J B Taheri, P Toossi, S Azimi, Sh Kawosi Nezhad
AIM: To investigate the prevalence of oral lichen planus in patients younger than 18 years, referred to a dermatology centre in Iran during 2002-2014. Lichen planus is a chronic inflammatory, immune-mediated disease that could affect the oral mucosa and is a pre-cancerous condition. The disease usually develops in middle age with female predominance and is rare in children. METHODS: In this retrospective study, cases with definitive histopathologic diagnosis of lichen planus, over a 12-year period from 2002 to 2014 from a dermatologic hospital archive were evaluated...
December 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29124831/a-prospective-observational-study-to-compare-efficacy-of-topical-triamcinolone-acetonide-0-1-oral-paste-oral-methotrexate-and-a-combination-of-topical-triamcinolone-acetonide-0-1-and-oral-methotrexate-in-moderate-to-severe-oral-lichen-planus
#8
P Chauhan, D De, S Handa, T Narang, U N Saikia
Topical corticosteroids are considered to be the most effective treatment for oral lichen planus (OLP). Methotrexate has been found to be effective in extensive cutaneous lichen planus. The objectives of the study were to evaluate the clinical efficacy and safety of topical triamcinolone 0.1% oral paste, oral methotrexate and a combination of these in symptomatic moderate-to- severe OLP. Forty-five patients were recruited and were allocated to three treatment arms with 15 patients in each treatment arm. They were treated for a period of 16 weeks or until complete clinical remission, whichever was earlier...
November 10, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28993983/skin-manifestations-associated-with-autoimmune-liver-diseases-a-systematic-review
#9
REVIEW
Benedetta Terziroli Beretta-Piccoli, Pietro Invernizzi, M Eric Gershwin, Carlo Mainetti
Autoimmune liver diseases, which include mainly autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and the variant syndromes, are often associated with extrahepatic autoimmune diseases. However, the association with cutaneous diseases is less well described. In the present article, we provide a systematic literature review on skin manifestations linked to each of these four autoimmune liver diseases, excluding skin manifestations of systemic diseases. The association of autoimmune hepatitis with vitiligo is well known, with a particular striking association with type 2 autoimmune hepatitis, a condition occurring almost entirely in children and adolescents, much rarer and more aggressive than type 1 autoimmune hepatitis; probable associations are also identified with alopecia areata, psoriasis, and pyoderma gangrenosum...
December 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28951706/does-the-corticotropin-releasing-hormone-system-play-a-role-in-the-pathogenesis-of-lichen-planus
#10
Bengu Cevirgen Cemil, Demet Yilmazer, Hatice Atas, Fatma Pelin Cengiz, Filiz Canpolat, Murat Alper, Muzeyyen Gonul
INTRODUCTION: Lichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis. AIM: To determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP. MATERIAL AND METHODS: Thirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the disease and body surface area (BSA) covered by the lesions was recorded...
August 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28940245/micrornas-in-cutaneous-lichen-planus
#11
A A El-Rifaie, L A Rashed, R W Doss, S T Osman
Lichen planus (LP) is a chronic, inflammatory, papulosquamous, autoimmune disease. The pathogenesis of LP appears to be complex, with interactions between genetic, environmental and lifestyle factors. MicroRNAs (miRNAs) are short RNAs encoded in both protein coding and noncoding areas of the genome, and have been found to be involved in the pathogenesis of some inflammatory skin diseases. The aim of this study was to map the levels of miRNA (miR-)-203 and miR-125b in cutaneous LP to evaluate their possible role in the pathogenesis of the disease...
September 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28895668/concepts-and-controversies-in-the-treatment-of-cutaneous-lichen-planus
#12
Charles Puza, Adela R Cardones
Cutaneous lichen planus (CLP) is a chronic autoimmune disease classically associated with severely pruritic, polygonal, violaceous, flat-topped papules and plaques. Subtypes such as hypertrophic and bullous lichen planus and lichen planus pigmentosus have been described. Treatment can be challenging, and prospective controlled studies are lacking. Corticosteroids remain the major options for topical and systemic treatment, although some non-steroidal options exist. Phototherapy, especially with narrow band ultraviolet B (NB-UVB), is effective, but caution must be taken because of the risk of keobnerization...
December 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28876421/secondary-syphilis-the-great-imitator-can-t-be-forgotten
#13
Clarissa Prieto Herman Reinehr, Célia Luiza Petersen Vitello Kalil, Vinícius Prieto Herman Reinehr
Syphilis is an infection caused by Treponema pallidum, mainly transmitted by sexual contact. Since 2001, primary and secondary syphilis rates started to rise, with an epidemic resurgence. The authors describe an exuberant case of secondary syphilis, presenting with annular and lichen planus-like lesions, as well as one mucocutaneous lesion. Physicians must be aware of syphilis in daily practice, since the vast spectrum of its cutaneous manifestations is rising worldwide.
June 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28869787/the-microbiology-of-oral-lichen-planus-is-microbial-infection-the-cause-of-oral-lichen-planus
#14
Keumjin Baek, Youngnim Choi
Oral lichen planus (OLP) is a variant of LP, a common chronic mucocutaneous inflammatory disease. While cutaneous lesions of LP are self-limiting, OLP lesions are non-remissive, alternating periods of exacerbation and quiescence, and only symptomatic treatments exist for OLP. The precise etiology and pathogenesis of OLP are hardly understood, which is a major obstacle to the development of new therapeutics for this disease. OLP is considered a T cell-mediated inflammatory disease. Although various antigens have been considered, what actually triggers the inflammatory response of T cells is unknown...
September 4, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/28794568/severely-crusted-cheilitis-as-an-initial-presentation-of-systemic-lupus-erythematosus
#15
Wai Man Mandy Chan, Shiu Ming Pang, See Ket Ng
Lupus erythematosus (LE) is an autoimmune disease which may initially present solely with lip lesions. Due to a wide spectrum of presentation, these features may initially be misdiagnosed as other oral diseases such as lichen planus, erythema multiforme (EM), and actinic cheilitis, leading to a delay in diagnosis and treatment. We discuss a case of severely crusted cheilitis which was initially diagnosed as EM, with subsequent development of subacute cutaneous LE, and progression to systemic LE. We will discuss the clinical and histological features of lupus cheilitis...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28716436/frontal-fibrosing-alopecia-among-men-a%C3%A2-clinicopathologic-study-of-7-cases
#16
Stanislav N Tolkachjov, Hafsa M Chaudhry, Michael J Camilleri, Rochelle R Torgerson
BACKGROUND: Frontal fibrosing alopecia (FFA) is a lichen planopilaris-variant scarring alopecia that has rarely been described in men. OBJECTIVE: To characterize the clinicopathologic findings of FFA in men by studying a series of 7 male patients. METHODS: We conducted a retrospective review of all cases of male patients with FFA at the Mayo Clinic from 1992 to 2016. RESULTS: Seven male patients with FFA were identified...
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28705287/generalized-discoid-lupus-erythematosus-as-the-presenting-sign-of-small-cell-lung-carcinoma
#17
Tania M Gonzalez Santiago, David A Wetter, Garrett C Lowe, Gabriel F Sciallis
A 46-year-old woman with a 30 pack-year smoking history presented with a worsening eruption on the left cheek that failed to improve with metronidazole gel. The cutaneous eruption spread to most of her face and did not respond to a brief tapering course of prednisone. During the initial evaluation at our institution, approximately 6 weeks after the onset of the cutaneous eruption, the patient had erythematous, crusted plaques on her face and scalp (Figure 1A); they were also present on the V-area of the anterior aspect of the neck and upper region of the chest, the shoulders, and the arms, with isolated lesions on the trunk and legs...
2017: Skinmed
https://www.readbyqxmd.com/read/28702966/possible-role-of-helicobacter-pylori-in-diseases-of-dermatological-interest
#18
C Guarneri, J Lotti, M Fioranelli, M G Roccia, T Lotti, F Guarneri
Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. pylori infection were suggested in diseases of dermatological interest such as chronic urticaria, rosacea, Henoch-Schoenleins purpura, idiopathic thrombocytopenic purpura, cutaneous and oral lichen planus, atopic dermatitis, recurrent aphthous stomatitis, systemic sclerosis, psoriasis, Sjögrens syndrome, Behçet's disease, pruritus, alopecia areata, primary cutaneous marginal zone B-cell lymphomas, vitiligo, chronic prurigo, multiformis, prurigo nodularis, leukocytoclastic vasculitis, prurigo pigmentosa, eczema nummulare, primary cutaneous MALT-type lymphoma, sublamina densa-type linear IgA bullous dermatosis, Sweet's syndrome, cutaneous T-cell pseudolymphoma and pemphigus vulgaris...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28701998/thyroid-autoimmunity-and-lichen
#19
REVIEW
Fabrizio Guarneri, Roberta Giuffrida, Flavia Di Bari, Serafinella Patrizia Cannavò, Salvatore Benvenga
Lichen planus (LP) and lichen sclerosus (LS) are cutaneous-mucous diseases with uncertain epidemiology. Current data, which are likely to be underestimated, suggest a prevalence in the general population of 0.1-4% for cutaneous LP, 1.27-2.0% for oral LP, and 0.1-3.3% for LS. While etiology of lichen is still unknown, clinical and histological evidence show an (auto)immune pathogenesis. Association of lichen with autoimmune thyroid disease (AITD) has been investigated in few studies. This association appears better defined in the case of LS, while is more controversial for LP...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28697228/lichenoid-dermatitis-from-interferon-alpha-2a-in-a-patient-with-metastatic-renal-cell-carcinoma-and-seronegative-hcv
#20
Amelia E Bush, Sharon R Hymes, Sirunya Silapunt
<p>Cutaneous reactions to interferon, including a lichenoid drug reaction, are most commonly reported in patients undergoing treatment for hepatitis C virus (HCV) infection. There have been case reports of interferon-induced lichen planus in seronegative HCV patients with lymphoproliferative disorders and melanoma. We report the case of a 71-year-old man undergoing treatment with interferon for metastatic renal cell carcinoma (RCC) who developed an eruption 2 months after starting interferon. Clinical and histological findings from biopsies supported a diagnosis of interferon-induced lichen planus...
July 1, 2017: Journal of Drugs in Dermatology: JDD
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