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https://www.readbyqxmd.com/read/28110400/multiplex-pcr-as-a-novel-method-in-the-diagnosis-of-spinal-tuberculosis-a-pilot-study
#1
Kusum Sharma, Rajesh Kumar Meena, Ashish Aggarwal, Rajesh Chhabra
BACKGROUND: Establishment of a reliable and rapid diagnosis is of paramount importance in spinal tuberculosis. The available gadgetry of investigations, such as AFB smear, culture of Mycobacterium tuberculosis, and Uniplex PCR, suffers from a lack of adequate sensitivity and/or a lack of rapidity. Therefore, many times a diagnosis is made either very late in the disease process or sometimes empirical therapy has to be started because a definite diagnosis could not be made. All of these are not ideal situations for a clinician...
January 21, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28110358/pollution-assessment-of-the-biob%C3%A3-o-river-chile-prioritization-of-substances-of-concern-under-an-ecotoxicological-approach
#2
Álvaro Alonso, Ricardo Figueroa, Pilar Castro-Díez
The water demand for human activities is rapidly increasing in developing countries. Under these circumstances, preserving aquatic ecosystems should be a priority which requires the development of quality criteria. In this study we perform a preliminary prioritization of the risky substances based on reported ecotoxicological studies and guidelines for the Biobío watershed (Central Chile). Our specific aims are (1) reviewing the scientific information on the aquatic pollution of this watershed, (2) determining the presence and concentration of potential toxic substances in water, sediment and effluents, (3) searching for quality criteria developed by other countries for the selected substances and (4) prioritizing the most risky substances by means of deterministic ecotoxicological risk assessment...
January 21, 2017: Environmental Management
https://www.readbyqxmd.com/read/28110330/prognostic-advantage-of-docetaxel-cisplatin-5-fluorouracil-neoadjuvant-chemotherapy-in-clinical-stage-ii-iii-esophageal-squamous-cell-carcinoma-due-to-excellent-control-of-preoperative-disease-and-postoperative-lymph-node-recurrence
#3
Keishi Yamashita, Kei Hosoda, Hiromitsu Moriya, Chikatoshi Katada, Mitsuhiro Sugawara, Hiroaki Mieno, Shoko Komori, Natsuya Katada, Masahiko Watanabe
BACKGROUND: Neoadjuvant chemotherapy (NAC) has become prevalent in esophageal squamous cell carcinoma (ESCC), but its long-term prognostic advantages remain unclear. The latest prognostic outcomes in clinical Stage (cStage) II/III ESCC with NAC were herein elucidated. PATIENTS AND METHODS: NAC prior to curative treatment was done in 115 cStage II/III ESCC patients with either cisplatin (CDDP)/5-fluorouracil (5-FU; CF) (n = 41) or docetaxel/CDDP/5-FU (DCF) NAC (n = 74) between 2007 and 2013...
January 21, 2017: Oncology
https://www.readbyqxmd.com/read/28110270/assessment-of-neonatal-pain-during-heel-prick-lancet-vs-needle-a-randomized-controlled-study
#4
Carl Britto, Suman P N Rao
BACKGROUND: Heel prick is a frequent painful procedure in newborns. A lancet or a 26-gauge needle is used for a heel prick in India. OBJECTIVE: To compare the pain caused by heel prick with a lancet or a 26-gauge needle in newborns admitted in the neonatal intensive care unit (NICU) using the preterm infant pain profile (PIPP). METHODS: This randomized controlled trial was conducted over 2 months in a Level III NICU with a sample size of 40 subjects (20 in each group), which was required for the study to have a power of 80% with an alpha error of 0...
January 21, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28110216/positron-emission-tomography-computed-tomography-and-4-hydroxynonenal-histidine-immunohistochemistry-reveal-differential-onset-of-lipid-peroxidation-in-primary-lung-cancer-and-in-pulmonary-metastasis-of-remote-malignancies
#5
Nevenka Piskač Živković, Mladen Petrovečki, Čedna Tomasović Lončarić, Igor Nikolić, Georg Waeg, Morana Jaganjac, Kamelija Žarković, Neven Žarković
: The Aim of the study was to reveal if PET-CT analysis of primary and of secondary lung cancer could be related to the onset of lipid peroxidation in cancer and in surrounding non-malignant lung tissue. METHODS: Nineteen patients with primary lung cancer and seventeen patients with pulmonary metastasis were involved in the study. Their lungs were analyzed by PET-CT scanning before radical surgical removal of the cancer. Specific immunohistochemistry for the major bioactive marker of lipid peroxidation, 4-hydroxynonenal (HNE), was done for the malignant and surrounding non-malignant lung tissue using genuine monoclonal antibody specific for the HNE-histidine adducts...
January 11, 2017: Redox Biology
https://www.readbyqxmd.com/read/28109733/course-of-participation-after-subarachnoid-hemorrhage
#6
Elize M Kruisheer, Irene M C Huenges Wajer, Johanna M A Visser-Meily, Marcel W M Post
OBJECTIVES: The study aimed to investigate participation problems in patients with subarachnoid hemorrhage (SAH), and the course of participation between 3 and 12 months post-SAH, and to identify determinants of this course. DESIGN: This is a prospective cohort study. SETTING: The study was done in the SAH outpatient clinic at the University Medical Center Utrecht. SUBJECTS: Subjects included patients independent in activities of daily living who visited the SAH outpatient clinic for a routine follow-up visit 3 months after the event...
January 18, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28109646/post-traumatic-stress-disorder-and-cardiovascular-disease
#7
REVIEW
Donald Edmondson, Roland von Känel
In this paper, a first in a Series of two, we look at the evidence for an association of post-traumatic stress disorder with incident cardiovascular disease risk and the mechanisms that might cause this association, as well as the prevalence of post-traumatic stress disorder due to cardiovascular disease events and its associated prognostic risk. We discuss research done after the publication of previous relevant systematic reviews, and survey currently funded research from the two most active funders in the field: the National Institutes of Health and the US Veterans Administration...
January 18, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28109574/revascularization-strategies-and-outcomes-in-elderly-patients-with-multivessel-coronary-disease
#8
J Trevor Posenau, Daniel M Wojdyla, Linda K Shaw, Karen P Alexander, E Magnus Ohman, Manesh R Patel, Peter K Smith, Sunil V Rao
BACKGROUND: Balancing risks and benefits of revascularization in elderly patients with multivessel coronary artery disease (CAD) is challenging. The appropriate revascularization strategy for elderly patients with multivessel CAD is unclear. METHODS: We used the Duke Databank for Cardiovascular Disease to identify patients aged 75 years or more who had multivessel disease and treatment with percutaneous coronary intervention or coronary artery bypass graft surgery (CABG) within 30 days of the index catheterization between October 1, 2003, and June 30, 2013...
January 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109571/in%C3%A2-vivo-tissue-engineering-of-human%C3%A2-airways
#9
Emmanuel Martinod, Joseph Paquet, Hervé Dutau, Dana M Radu, Morad Bensidhoum, Sébastien Abad, Yurdagül Uzunhan, Eric Vicaut, Hervé Petite
BACKGROUND: Airway transplantation remains a major challenge in thoracic surgery. Based on our previous laboratory work, we developed the techniques required to bioengineer a tracheal substitute in vivo using cryopreserved aortic allografts as biological matrices (Replacement of the Airways and/or the Pulmonary Vessels Using a Cryopreserved Arterial Allograft [TRACHEOBRONCART] Study, NCT01331863). We present here 2 patients who had a definitive tracheostomy for complex laryngotracheal stenoses refractory to conventional therapy...
January 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109500/is-routine-audiometric-testing-necessary-for-children-with-isolated-preauricular-lesions
#10
Grace T Wu, Conor Devine, Allen Xu, Katie Geelan-Hansen, Samantha Anne
INTRODUCTION: Preauricular lesions, including tags, pits, sinuses, and cysts are commonly seen. Some studies have shown increased incidence of hearing loss in these patients but other studies have failed to corroborate this finding. The purpose of this study is to evaluate the incidence of hearing loss in patients with isolated preauricular lesions. METHODS: Retrospective chart review of all pediatric otolaryngology patients seen at a tertiary academic center between 2008 and 2014...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28109317/sorting-nexin-4-regulates-%C3%AE-amyloid-production-by-modulating-%C3%AE-site-activating-cleavage-enzyme-1
#11
Na-Young Kim, Mi-Hyang Cho, Se-Hoon Won, Hoe-Jin Kang, Seung-Yong Yoon, Dong-Hou Kim
BACKGROUND: Amyloid precursor protein (APP) is cleaved by β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) to produce β-amyloid (Aβ), a critical pathogenic peptide in Alzheimer's disease (AD). Aβ generation can be affected by the intracellular trafficking of APP or its related secretases, which is thus important to understanding its pathological alterations. Although sorting nexin (SNX) family proteins regulate this trafficking, the relevance and role of sorting nexin-4 (SNX4) regarding AD has not been studied yet...
January 21, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28109281/evaluation-of-a-program-to-strengthen-general-practice-care-for-patients-with-chronic-disease-in-germany
#12
Michel Wensing, Joachim Szecsenyi, Christian Stock, Petra Kaufmann Kolle, Gunter Laux
BACKGROUND: A program to strengthen general practice care for patients with chronic disease was offered in Germany. Enrollment was a free individual choice for both patients and physicians. This study aimed to examine the long-term impact of this program. METHODS: Two comparative evaluations were done, at 4 and 5 years (T1 and T2) after start of the program. In each year, patients in the program were compared with patients in usual care. Measures were based on routinely collected data and concerned 11 aspects of primary care and hospital care...
January 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28109192/prevalence-of-oral-manifestations-in-children-and-adolescents-with-cancer-submitted-to-chemotherapy
#13
Deise Berger Velten, Eliana Zandonade, Maria Helena Monteiro de Barros Miotto
BACKGROUND: Oral complications may be observed during chemotherapy and are important side effects that may directly affect the anticancer treatment, even causing septicaemia in some cases. This research was done in order to evaluate changes in oral lesions during follow-up of children and adolescents in chemotherapy at Hospital Estadual Infantil Nossa Senhora da Glória (HEINSG). METHODS: The study design was longitudinal, 45 patients were evaluated and monitored for 1 month after the initiation of chemotherapy...
January 20, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28108976/phenotypic-and-biochemical-alterations-in-relation-to-mt2-gene-expression-in-plantago-ovata-forsk-under-zinc-stress
#14
Paulami Pramanick, Anindita Chakraborty, Sarmistha Sen Raychaudhuri
Plantago ovata Forsk is an annual herb with immense medicinal importance, the seed and husk of which is used in the treatment of chronic constipation, irritable bowel syndrome, diarrhea since ancient times. Zinc, an essential metal, is required by plants as they form important components of zinc finger proteins and also aid in synthesis of photosynthetic pigments such as chlorophyll. However, in excess amount Zn causes chlorosis of leaf and shoot tissues and generate reactive oxygen species. The present study is aimed at investigating the changes in expression levels of MT2 gene in Plantago ovata under zinc stress...
January 20, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28108815/preoperative-nlr-for-predicting-survival-rate-after-radical-resection-combined-with-adjuvant-immunotherapy-with-cik-and-postoperative-chemotherapy-in-gastric-cancer
#15
Yingchun Li, Chenyu Wang, Mengdan Xu, Cuicui Kong, Aibing Qu, Meng Zhang, Zhichao Zheng, Guirong Zhang
PURPOSE: The purpose of this study is to determine the efficacy of adjuvant immunotherapy with autologous cytokine-induced killer (CIK) for postoperative patients with gastric cancer and to investigate the impacts of the predictors on the efficacy of CIK immunotherapy. PATIENTS AND METHODS: Ninety-two gastric cancer patients who have accepted radical resection were enrolled. The CIK and control groups were established by 1:1 matching on their baseline. As prognosis indicators, preoperative blood cell counts, the neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) were analyzed, respectively...
January 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28108712/where-s-welfare-redesigning-our-food-for-the-future
#16
(no author information available yet)
While there is a need to feed a growing global population, this must be done in a way that is compatible with achieving climate change objectives and promoting social justice and environmental stewardship, while also accounting for the interests of animals farmed for food. A session at the BVA Congress during the London Vet Show in November asked where animal welfare might lie within future food production systems. Olivia Azouaghe reports.
January 21, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28108641/spinal-cord-stimulation-scs-with-anatomically-guided-3d-neural-targeting-shows-superior-chronic-axial-low-back-pain-relief-compared-to-traditional-scs-lumina-study
#17
Elias Veizi, Salim M Hayek, James North, T Brent Chafin, Thomas L Yearwood, Louis Raso, Robert Frey, Kevin Cairns, Anthony Berg, John Brendel, Nameer Haider, Matthew McCarty, Henry Vucetic, Alden Sherman, Lilly Chen, Nitzan Mekel-Bobrov
: BACKGROUND : The aim of this study was to determine whether spinal cord stimulation (SCS) using 3D neural targeting provided sustained overall and low back pain relief in a broad routine clinical practice population. STUDY DESIGN AND METHODS:  This was a multicenter, open-label observational study with an observational arm and retrospective analysis of a matched cohort. After IPG implantation, programming was done using a patient-specific, model-based algorithm to adjust for lead position (3D neural targeting) or previous generation software (traditional)...
January 20, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28108593/the-differentiated-effects-of-health-on-political-participation
#18
Jérôme Couture, Sandra Breux
BACKGROUND: Several studies have shown that an individual's state of health can significantly affect their decision to vote, but analysis is often only done on a single level of government; the national level. However, prior research has shown that the determining factors for voting can differ according to the level of government being considered. Our analysis is the first attempt to take a comprehensive look at the magnitude of health and political participation in a same country on different levels...
January 19, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28108483/measuring-hip-muscle-strength-in-patients-with-femoroacetabular-impingement-and-other-hip-pathologies-a-systematic-review
#19
E Mayne, A Memarzadeh, P Raut, A Arora, V Khanduja
OBJECTIVES: The aim of this study was to systematically review the literature on measurement of muscle strength in patients with femoroacetabular impingement (FAI) and other pathologies and to suggest guidelines to standardise protocols for future research in the field. METHODS: The Cochrane and PubMed libraries were searched for any publications using the terms 'hip', 'muscle', 'strength', and 'measurement' in the 'Title, Abstract, Keywords' field. A further search was performed using the terms 'femoroacetabular' or 'impingement'...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28108406/berry-s-ligament-and-the-inferior-thyroid-artery-as-reliable-anatomical-landmarks-for-the-recurrent-laryngeal-nerve-a-fresh-cadaveric-study-of-the-cervical-spine-the-recurrent-laryngeal-nerve-rln-relevant-to-spine
#20
Ali Rajabian, Michael Walsh, Nasir A Quraishi
BACKGROUND CONTEXT: Whilst most cadaveric studies of the RLN have focused on course variations, they have usually been done on preserved (fixed and embalmed) cadavers which renders the RLN immobile and of less surgical landmark value. PURPOSE: Our aim was to perform a thorough exposure in fresh cadavers with the intention of investigating inferior thyroid artery and Berry's ligament as reliable landmarks for the identification of the RLN in anterior cervical spine surgery...
January 17, 2017: Spine Journal: Official Journal of the North American Spine Society
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