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https://www.readbyqxmd.com/read/28335271/distribution-of-iron-oxide-core-titanium-dioxide-shell-nanoparticles-in-vx2-tumor-bearing-rabbits-introduced-by-two-different-delivery-modalities
#1
Tamer Refaat, Derek West, Samar El Achy, Vamsi Parimi, Jasmine May, Lun Xin, Kathleen R Harris, William Liu, Michael Beau Wanzer, Lydia Finney, Evan Maxey, Stefan Vogt, Reed A Omary, Daniele Procissi, Andrew C Larson, Tatjana Paunesku, Gayle E Woloschak
This work compares intravenous (IV) versus fluoroscopy-guided transarterial intra-catheter (IC) delivery of iron oxide core-titanium dioxide shell nanoparticles (NPs) in vivo in VX2 model of liver cancer in rabbits. NPs coated with glucose and decorated with a peptide sequence from cortactin were administered to animals with developed VX2 liver cancer. Two hours after NPs delivery tumors, normal liver, kidney, lung and spleen tissues were harvested and used for a series on histological and elemental analysis tests...
August 3, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334617/comparison-of-two-dimensional-synthesized-mammogram-2dsm-and-conventional-full-field-digital-mammogram-ffdm-for-evaluation-of-breast-cancer
#2
Gayoung Choi, Ok Hee Woo, Hye Seon Shin, Seonah Jang, Kyu Ran Cho, Bo Kyoung Seo
PURPOSE: To compare the diagnostic efficacy of 2DSM and FFDM for evaluation of breast cancer. MATERIALS AND METHODS: A retrospective observer performance study was done by 3 breast radiologists. The diagnostic accuracy, image quality, and detailed lesion characterization of each 2DSM and FFDM were evaluated blindly to determine superior modality. RESULTS: The diagnostic accuracy was not significantly different between two modalities. The image quality was superior in 2DSM (p-value 0...
March 8, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28334507/comparative-study-of-cytotoxicity-and-genotoxicity-of-commercial-jeffamines%C3%A2-and-polyethylenimine-in-cho-k1-cells
#3
Leniher Castan, Cristiano José da Silva, Eduardo Ferreira Molina, Raquel Alves Dos Santos
Jeffamines(®) are a family of polymers containing primary amine groups attached to the extremities of polyether backbone which can be used as biomaterials. They have been used in combination with polyethylenimine (PEI) to improve biocompatibility in drug and gene delivery systems. Despite these facts, very few studies have been done on cytotoxicity and genotoxicity of pure Jeffamines(®) or compared with PEI. The present study aimed to evaluate and compare the cytotoxic and genotoxic effects of Jeffamines(®) and PEI in CHO-K1 cells...
March 23, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28334466/home-care-services-for-sick-children-healthcare-professionals-conceptions-of-challenges-and-facilitators
#4
Charlotte Castor, Inger Hallström, Helena Hansson, Kajsa Landgren
AIMS AND OBJECTIVES: To explore healthcare professionals' conceptions of caring for sick children in home care services. BACKGROUND: Families often prefer home care to hospital care and the number of home care services for children is increasing. Caring for children at home has been recognised as challenging for healthcare professionals in home care services used to providing care predominately for adults. DESIGN: An inductive qualitative design...
March 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28334313/colour-vision-requirements-in-visually-demanding-occupations
#5
J L Barbur, M Rodriguez-Carmona
Normal trichromatic colour vision (CV) is often required as a condition for employment in visually demanding occupations. If this requirement could be enforced using current, colour assessment tests, a significant percentage of subjects with anomalous, congenital trichromacy who can perform the suprathreshold, colour-related tasks encountered in many occupations with the same accuracy as normal trichromats would fail. These applicants would therefore be discriminated against unfairly. One solution to this problem is to produce minimum, justifiable CV requirements that are specific to each occupation...
March 18, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28334310/different-from-trees-more-than-metaphors-branching-silhouettes-corals-cacti-and-the-oaks
#6
János Podani
There has long been ambiguity in the use of the term tree in phylogenetic systematics, which is a continuous source of misinterpretation of evolutionary relationships. The basic problem is that while many trees with phylogenetic or evolutionary relevance, such as cladograms, are consistent with graph theory, tree-like visualization of phylogeny may also be done via other types of graphics, especially botanical (or literal) tree drawings. As a consequence, the meaning of such diagrams is not always clear: a given picture may have multiple interpretations in its different parts and two figures that look similar may actually carry quite different information...
March 11, 2017: Systematic Biology
https://www.readbyqxmd.com/read/28334165/ctsge-clustering-subgroups-of-expression-data
#7
Michal Sharabi-Schwager, Etti Or, Ron Ophir
Summary: A prerequisite to clustering noisy data, such as gene-expression data, is the filtering step. As an alternative to this step, the ctsGE R-package applies a sorting step in which all of the data are divided into small groups. The groups are divided according to how the time points are related to the time-series median. Then clustering is performed separately on each group. Thus, the clustering is done in two steps. First, an expression index (i.e., a sequence of 1, -1, and 0) is defined and genes with the same index are grouped together, and then each group of genes is clustered by k-means to create subgroups...
March 3, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28334128/trap-height-affects-capture-of-lady-beetles-coleoptera-coccinellidae-in-pecan-orchards
#8
T E Cottrell
There is scarce information regarding the vertical stratification of predaceous Coccinellidae in tall trees. Although numerous studies have been done in orchards and forests, very few studies have assessed the occurrence of predaceous Coccinellidae high in tree canopies. The objective of this study was to examine the abundance of Coccinellidae at different heights in mature pecan, Carya illinoinensis (Wangenh.) K. Koch, orchards with tall trees. From spring through late fall during 2013 and 2014, yellow pyramidal Tedders traps were suspended in the pecan canopy at 6...
February 17, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28334045/plasma-soluble-l-selectin-in-medicated-patients-with-schizophrenia-and-healthy-controls
#9
Satyajit Mohite, Fang Yang, Pooja A Amin, Giovana Zunta-Soares, Gabriela D Colpo, Laura Stertz, Ajaykumar N Sharma, Gabriel R Fries, Consuelo Walss-Bass, Jair C Soares, Olaoluwa O Okusaga
Immune dysfunction has been implicated in the pathophysiology of schizophrenia. Leukocyte migration to the site of inflammation is a fundamental step of immune response which involves P-, E-, and L-selectins. Elevated selectin levels have been reported in un-medicated first-episode patients with schizophrenia but not in medicated patients with multi-episode schizophrenia. We measured fasting plasma soluble P-, E-, and L-selectin in 39 medicated patients with multi-episode schizophrenia and 19 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28333881/outer-retinal-layer-thickness-as-good-visual-predictor-in-patients-with-diabetic-macular-edema
#10
Tamer F Eliwa, Mahdi A Hussein, Mohamed A Zaki, Osama A Raslan
PURPOSE: To evaluate the relationship between outer retinal layer (ORL) thickness in diabetic macular edema to visual acuity (VA). METHODS: Ninety-five eyes were included in this prospective nonrandomized case-control study. They divided into 30 cases of healthy normal subjects and 65 cases of nonproliferative diabetic retinopathy with diabetic macular edema. Complete ophthalmic examination and spectral domain-optical coherence tomography were done for all cases and analyzed to measure central foveal point thickness (CFT), ORL thickness at fovea, and subfoveal choroidal thickness...
March 22, 2017: Retina
https://www.readbyqxmd.com/read/28333821/committee-opinion-no-693-counseling-about-genetic-testing-and-communication-of-genetic-test-results
#11
(no author information available yet)
Given the increasing availability and complexity of genetic testing, it is imperative that the practicing obstetrician-gynecologist or other health care provider has a firm comprehension of the benefits, limitations, and risks of offering a specific genetic test, as well as the importance of appropriate pretest and posttest counseling. The purpose of this Committee Opinion is to provide an outline of how obstetrician-gynecologists and other health care providers can best incorporate these tests into their current practices and provide appropriate pretest and posttest counseling to patients...
April 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28333813/committee-opinion-no-693-summary-counseling-about-genetic-testing-and-communication-of-genetic-test-results
#12
(no author information available yet)
Given the increasing availability and complexity of genetic testing, it is imperative that the practicing obstetrician-gynecologist or other health care provider has a firm comprehension of the benefits, limitations, and risks of offering a specific genetic test, as well as the importance of appropriate pretest and posttest counseling. The purpose of this Committee Opinion is to provide an outline of how obstetrician-gynecologists and other health care providers can best incorporate these tests into their current practices and provide appropriate pretest and posttest counseling to patients...
April 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28333684/entropy-production-in-photovoltaic-thermoelectric-nanodevices-from-the-non-equilibrium-green-s-function-formalism
#13
Fabienne Michelini, Adeline Crépieux, Katawoura Beltako
We discuss some thermodynamic aspects of energy conversion in electronic nanosystems able to convert light energy into electrical or/and thermal energy using the non-equilibrium Green's function formalism. In a first part, we derive the photon energy and particle currents inside a nanosystem interacting with light and in contact with two electron reservoirs at different temperatures. Energy conservation is verified, and radiation laws are discussed from electron non-equilibrium Green's functions. We further use the photon currents to formulate the rate of entropy production for steady-state nanosystems, and we recast this rate in terms of efficiency for specific photovoltaic-thermoelectric nanodevices...
March 23, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28333648/mobile-stride-length-estimation-with-deep-convolutional-neural-networks
#14
Julius Hannink, Thomas Kautz, Cristian Pasluosta, Jens Barth, Samuel Schulein, Karl-Gunter Gassmann, Jochen Klucken, Bjoern Eskofier
OBJECTIVE: Accurate estimation of spatial gait characteristics is critical to assess motor impairments resulting from neurological or musculoskeletal disease. Currently, however, methodological constraints limit clinical applicability of state-ofthe- art double integration approaches to gait patterns with a clear zero-velocity phase. METHODS: We describe a novel approach to stride length estimation that uses deep convolutional neural networks to map stride-specific inertial sensor data to the resulting stride length...
March 9, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28333608/morbidity-in-pregnant-women-associated-with-unverified-penicillin-allergies-antibiotic-use-and-group-b-streptococcus-infections
#15
Shilpa H Desai, Michael S Kaplan, Qiaoling Chen, Eric M Macy
CONTEXT: The morbidity potentially associated with unverified penicillin allergy in pregnant women, with and without group B streptococcus (GBS) infections, is unknown. Penicillin allergy testing is safe during pregnancy but is done infrequently. OBJECTIVE: To determine morbidity associated with antibiotic use in a large cohort of pregnant women, with and without an unverified history of penicillin allergy, and with and without GBS. DESIGN: Retrospective...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28333559/technique-tip
#16
Gregory R Waryasz, Stephen Marcaccio, Joseph A Gil
Lisfranc injury fixation or arthrodesis typically involves the reduction and fixation of several tarsometatarsal joints with either screws or a plate and screw constructs. A successful fixation or arthrodesis of the Lisfranc joint requires proper screw placement from the medial cuneiform to the base of the second metatarsal. This is typically done free-hand; however, we describe use of an anterior cruciate ligament guide to help maintain reduction and assist with drill trajectory for more accurate screw or suture button construct placement...
April 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28333471/competition-between-light-induced-and-intrinsic-nonadiabatic-phenomena-in-diatomics
#17
András Csehi, Gabor J Halasz, Lorenz S Cederbaum, Agnes Vibok
Nonadiabatic effects arise due to avoided crossings or conical intersections which are present either naturally in field-free space or are induced by a classical laser field in a molecule. Recently, it was demonstrated that nonadiabatic effects in diatomics can also be created in an optical cavity. Here, the quantized radiation field mixes the nuclear and electronic degrees of freedom. We show the equivalence of using the cavity's quantized field and the classical laser field as usually done for molecules. This is demonstrated for NaI which exhibits a pronounced natural (intrinsic) avoided crossing which competes with the avoided crossing induced by the field...
March 23, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28333327/disclosure-of-donor-conception-age-of-disclosure-and-the-well-being-of-donor-offspring
#18
Guido Pennings
The matter of disclosure of donor conception to donor offspring is a very contentious issue. A frequently mentioned argument is that disclosure is in the best interest of the child. The objectives of this paper are 2-fold: first, to find out whether there are any measureable, stable differences in the psychological well-being of donor offspring who are informed of the mode of their conception compared to those who are not, and second, to find out what is being done with the evidence. We found that there exists no empirical evidence of differences in psychological well-being of donor offspring in disclosing or nondisclosing families...
March 15, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28333298/occurrence-and-molecular-characteristics-of-esbl-ampc-producing-escherichia-coli-in-faecal-samples-from-horses-in-an-equine-clinic
#19
Ilias Apostolakos, Eelco Franz, Angela H A M van Hoek, Alice Florijn, Christiaan Veenman, Marianne M Sloet-van Oldruitenborgh-Oosterbaan, Cindy Dierikx, Engeline van Duijkeren
Objectives: To investigate the occurrence and characteristics of ESBL/AmpC-producing Escherichia coli in faecal samples from horses at one equine clinic in the Netherlands. Methods: A total of 91 horses, including residents and patients, were sampled. ESBL/AmpC-producing E. coli were identified by a combination disc diffusion test. Phylogenetic groups and MLST were determined. ESBL/AmpC genes were analysed using PCR and sequencing. Plasmids were characterized by transformation and PCR-based replicon typing...
March 13, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28333034/treatment-of-thin-endometrium-with-autologous-platelet-rich-plasma-a-pilot-study
#20
Shahrzad Zadehmodarres, Saghar Salehpour, Nasrin Saharkhiz, Leila Nazari
Endometrium is one of the main factors in pregnancy. During assisted reproductive technology (ART) treatments, some cycles are cancelled due to inadequate endometrial growth. This study was conducted to evaluate the effectiveness of platelet-rich plasma (PRP) in the treatment of thin endometrium. Ten patients with history of inadequate endometrial growth in frozen-thawed embryo transfer (FET) cycles were recruited into the study. Intrauterine infusion of PRP was performed. Endometrial thickness was assessed...
February 1, 2017: JBRA Assisted Reproduction
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