keyword
https://read.qxmd.com/read/38546863/-evaluation-of-the-role-of-an-advanced-practice-dietitian-in-the-intensive-care-unit
#1
JOURNAL ARTICLE
Gioia Vinci, Reto Stocker
BACKGROUND: In Swiss intensive care units (ICUs), nutritional management is hardly or not at all supported or supervised by dietitians. Nutritional management in the ICU is mainly performed by ICU nursing staff and intensive care specialists. In 2022, the role of an advanced practice dietitian (APD) was newly defined, created, and implemented in a Swiss ICU as part of a pilot project. In contrast to other countries, APDs are still scarce in Switzerland. Evaluation of the APD role is essential to further define the position and adapt it to needs...
March 28, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://read.qxmd.com/read/38545757/feasibility-and-effectiveness-of-repeat-laparoscopic-pyeloplasty-for-recurrent-ureteropelvic-junction-obstruction-in-pediatric-patients
#2
JOURNAL ARTICLE
Qike Xie, Congjun Wang, Cheng Su, Bo Shi, Yong Li, Junqiang Huang, Chao Chen
OBJECTIVE: To assess the outcomes of redo laparoscopic pyeloplasty (RLP) in pediatric patients with recurrent ureteropelvic junction obstruction (UPJO) in contrast to redo open pyeloplasty (ROP). Additionally, evaluate the feasibility and efficacy of RLP as a treatment modality for recurrent UPJO in children. MATERIALS AND METHODS: The data of 44 patients from March 2012 to March 2022 who underwent redo pyeloplasty were retrospectively reviewed. In Group RLP, the children underwent RLP, while ROP was attempted in Group ROP...
March 28, 2024: Journal of Endourology
https://read.qxmd.com/read/38539678/auditory-processing-and-speech-sound-disorders
#3
REVIEW
Konstantinos Drosos, Alexandra Papanicolaou, Louiza Voniati, Klea Panayidou, Chryssoula Thodi
BACKGROUND: Speech-sound disorders (SSD) have been linked to auditory processing difficulties, and auditory processing disorders (APD) have been related to phonological awareness and literacy development. To this date, there has not been a systematic literature review investigating the results of psychophysiology and language assessments related to SSD and APD in children. METHODS: The literature search was conducted in PubMed, Medline EBSCO, and Scopus to identify studies with children diagnosed/suspected of having APDs and SSDs...
March 19, 2024: Brain Sciences
https://read.qxmd.com/read/38532382/depression-during-pregnancy-and-associated-factors-among-women-in-ethiopia-a-systematic-review-and-meta-analysis
#4
JOURNAL ARTICLE
Solomon Shitu Ayen, Abebaw Wasie Kasahun, Amare Zewdie
BACKGROUND: Pregnancy is one of the most remarkable experiences in a woman's life. Prenatal depression, characterized by stress and worry associated with pregnancy, can reach severe levels. On a global scale, mental and addictive disorders affect more than one billion people, causing 19% of years lived with disability. It is estimated that 25-35% of pregnant women experience depressive symptoms, with 20% meeting the diagnostic criteria for major depression. METHODS: A systematic review and meta-analysis were conducted to examine depression during pregnancy in Ethiopia...
March 26, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38525011/targeted-ultrasound-nanobubbles-therapy-for-prostate-cancer-via-immuno-sonodynamic-effect
#5
JOURNAL ARTICLE
Xin Huang, Yueying Chen, Fanglu Zhong, Bin Gui, Yugang Hu, Yuxin Guo, Qing Deng, Qing Zhou
BACKGROUND: Prostate cancer (PCa) poses a significant global health threaten. Immunotherapy has emerged as a novel strategy to augment the inhibition of tumor proliferation. However, the sole use of anti-PD-L1 Ab for PCa has not yielded improvements, mirroring outcomes observed in other tumor types. METHODS: This study employed the thin film hydration method to develop lipid nanobubbles (NBs) encapsulating chlorin e6 (Ce6) and anti-PD-L1 Ab (Ce6@aPD-L1 NBs). Our experimental approach included cellular assays and mouse immunization, providing a comprehensive evaluation of Ce6@aPD-L1 NBs' impact...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38524327/idiopathic-intracranial-hypertension-in-omani-adults-a-tertiary-center-experience
#6
JOURNAL ARTICLE
Buthaina Issa Sabt, Aisha Suleiman Al Busaidi, Sitara Azeem, Lojain Al Dhabbari
BACKGROUND: To evaluate the clinical profile, risk factors, and ophthalmic diagnostic and monitoring tools in Omani patients with idiopathic intracranial hypertension (IIH) using optical coherence tomography (OCT). METHODS: A retrospective single institutional cohort study on Omani patients with a fulfilled diagnosis of IIH from January 1, 2014, to January 1, 2020, was conducted. The data obtained from the neuro-ophthalmic clinic contained age of onset of the disease, gender of patients, body mass index (BMI), presence of other associated conditions, and medication use...
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38520087/pregnancy-outcomes-for-women-with-pre-existing-renal-disease-and-the-role-of-a-dedicated-joint-maternal-medicine-and-renal-clinic-a-retrospective-cohort-study
#7
JOURNAL ARTICLE
Bethany Wildridge, David Makanjuola, Antoinette Johnson, Ramesh Ganapathy, Lucy Mountford, Christina Bell, Jonathan Odogwu, Hassan Shehata
OBJECTIVE: To reaffirm the value of a joint obstetric and renal clinic on obstetric outcomes in patients with high-risk pregnancies due to chronic kidney disease (CKD). METHODS: This was a retrospective cohort study of patients who attended the clinic between 2005 and December 2021. The hospital is a regional tertiary unit for renal medicine and a maternal medicine hub. The data included all women with pre-existing renal conditions who were cared for in a dedicated renal and obstetric clinic...
March 22, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38512382/resuming-automated-peritoneal-dialysis-after-laparoscopic-peritoneal-wall-anchoring-for-peritoneal-dialysis-catheter-fixation
#8
JOURNAL ARTICLE
Masatoshi Matsunami, Tomo Suzuki, Koichiro Suzuki, Hiroshi Kuji
No abstract text is available yet for this article.
March 21, 2024: Journal of Nephrology
https://read.qxmd.com/read/38510543/automated-segmentation-of-the-left-ventricle-from-mri-with-a-fully-convolutional-network-to-investigate-ctrcd-in-breast-cancer-patients
#9
JOURNAL ARTICLE
Julia Kar, Michael V Cohen, Samuel A McQuiston, Teja Poorsala, Christopher M Malozzi
Purpose: The goal of this study was to develop a fully convolutional network (FCN) tool to automatedly segment the left-ventricular (LV) myocardium in displacement encoding with stimulated echoes MRI. The segmentation results are used for LV chamber quantification and strain analyses in breast cancer patients susceptible to cancer therapy-related cardiac dysfunction (CTRCD). Approach: A DeepLabV3+ FCN with a ResNet-101 backbone was custom-designed to conduct chamber quantification on 45 female breast cancer datasets (23 training, 11 validation, and 11 test sets)...
March 2024: Journal of Medical Imaging
https://read.qxmd.com/read/38509137/exploring-osteochondral-damage-patterns-in-acute-patellar-dislocation-insights-into-morphological-associations-and-risk-factors
#10
JOURNAL ARTICLE
Yu Gao, Chunxiao Wei, Modi Yang
Osteochondral damage (OD) is a significant outcome following acute patellar dislocation (APD), yet the factors contributing to its susceptibility remain unclear. The primary objective of this study was to assess the association between demographic characteristics, patellofemoral (PF) joint morphology, and the occurrence of OD. A retrospective analysis identified 74 patients with APD who underwent treatment in our unit between 2019 and 2022. All patients received MRI within a week of injury to assess OD, subsequently categorized according to the injury pattern...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38507157/significant-improvement-in-hydronephrosis-with-pyeloplasty-prior-to-3-months-of-age-in-patients-with-antenatal-severe-hydronephrosis
#11
JOURNAL ARTICLE
Amr Hodhod, Hadeel Eid, Carolina Fermin-Risso, Mutaz Farhad, Jarah Aburezq, Anthony Cook, Bryce Weber
INTRODUCTION: Pyeloplasty is the definitive management of ureteropelvic junction obstruction (UPJO). One of the challenging questions is when to perform pyeloplasty. We studied if improvement post-pyeloplasty in the first 3 months of life could show greater improvement in hydronephrosis than surgery at an older age. PATIENTS AND METHODS: Patients with postnatally diagnosed UPJO and underwent pyeloplasty in the first year of life were retrospectively reviewed. We excluded patients with concomitant vesicoureteral reflux, and patients who had pyeloplasty because of UTI or missed follow-up...
March 20, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38506151/peritoneal-phosphate-clearance-determinants-and-association-with-mortality
#12
JOURNAL ARTICLE
Jinping Li, Wenyu Zhang, Xichao Wang, Na Sun, Lei Li, Wenxiu Chang
BACKGROUND: Dialytic phosphate removal is a cornerstone of the management of hyperphosphatemia in peritoneal dialysis (PD) patients, but the influencing factors on peritoneal phosphate clearance (PPC) are incompletely understood. Our objective was to explore clinically relevant factors associated with PPC in patients with different PD modality and peritoneal transport status and the association of PPC with mortality. METHODS: This is a cross-sectional and prospective observational study...
March 20, 2024: Seminars in Dialysis
https://read.qxmd.com/read/38505095/use-of-phthalocyanine-derived-mouthwash-as-a-protective-factor-for-covid-19-a-community-trial
#13
JOURNAL ARTICLE
Verônica Caroline Brito Reia, Fabiano Vieira Vilhena, Heitor Marques Honório, Lucas Marques da Costa Alves, Roosevelt da Silva Bastos, Paulo Sérgio da Silva Santos
AIM: In a population profile corrected for sociodemographic factors, the aim of this study was to examine sociodemographic the protective effect of a phthalocyanine-derived mouthwash (APD) before infection with SARS-CoV-2, in addition to analyzing the survival of the at-risk population and the confirmed diagnosis of COVID-19. METHODS: For individuals from the Uru municipality, a structured questionnaire consisting of two parts was completed before the distribution of APD...
2024: GMS Hygiene and Infection Control
https://read.qxmd.com/read/38501921/relationship-between-cognitive-abilities-and-basic-auditory-processing-in-young-adults
#14
JOURNAL ARTICLE
Akshay R Maggu, Bhamini Sharma
PURPOSE: The diagnosis of auditory processing disorder (APD) is controversial particularly due to the influence of higher order factors of language and cognition on the diagnostic APD testing. As a result, there might be a need for testing for other domains (e.g., cognition) along with conducting the diagnostic APD testing to rule out the influence of other domains. In order to make recommendations on whether cognitive testing is needed along with the auditory processing testing, as a starting point, the current study was conducted to examine the relationship between cognitive abilities and basic auditory processing in young adults...
March 19, 2024: American Journal of Audiology
https://read.qxmd.com/read/38491656/intracellular-ion-accumulation-in-the-genesis-of-complex-action-potential-dynamics-under-cardiac-diseases
#15
JOURNAL ARTICLE
Xinyu Wang, Julian Landaw, Zhilin Qu
Intracellular ions, including sodium (Na^{+}), calcium (Ca^{2+}), and potassium (K^{+}), etc., accumulate slowly after a change of the state of the heart, such as a change of the heart rate. The goal of this study is to understand the roles of slow ion accumulation in the genesis of cardiac memory and complex action-potential duration (APD) dynamics that can lead to lethal cardiac arrhythmias. We carry out numerical simulations of a detailed action potential model of ventricular myocytes under normal and diseased conditions, which exhibit memory effects and complex APD dynamics...
February 2024: Physical Review. E
https://read.qxmd.com/read/38491151/depicted-simulation-model-for-removal-of-second-generation-antipsychotic-drugs-adsorbed-on-zn-mof-adsorption-locator-assessment
#16
JOURNAL ARTICLE
Ali Abdullah Issa, Maryam Dhary Kamel, Doaa S El-Sayed
CONTEXT: Electronic durable behavior on the material surface was accompanied by a class of antipsychotic drugs (APD) to describe the surface modification in the designed adsorption model. Hierarchically Zn-MOF system was utilized for estimating its capacity for drug molecule removal. Geometrically optimized strategy on the studied systems was performed using DFT/GGA/PBE. FMOs analysis was depicted based on the same level of calculations, and molecular electrostatic potential surface (MEP) was generated for unadsorbed and adsorbed systems to illustrate the variation in the surface-active sites...
March 16, 2024: Journal of Molecular Modeling
https://read.qxmd.com/read/38481516/familial-variability-of-disease-severity-in-adult-patients-with-adpkd
#17
JOURNAL ARTICLE
Elhussein A E Elhassan, Patrick O'Kelly, Kane E Collins, Omri Teltsh, Francesca Ciurli, Susan L Murray, Claire Kennedy, Stephen F Madden, Katherine A Benson, Gianpiero L Cavalleri, Peter J Conlon
INTRODUCTION: Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic nephropathy and has striking familial variability of disease severity. METHODS: To better comprehend familial phenotypic variability, we analyzed clinical and pedigree data on 92 unrelated ADPKD kindreds with ≥2 affected individuals ( N  = 292) from an Irish population. All probands underwent genetic sequencing. Age at onset of kidney failure (KF), decline in estimated glomerular filtration rate (eGFR), predicting renal outcome in polycystic kidney disease (PROPKD) score, and imaging criteria were used to assess and grade disease severity as mild, intermediate, or severe...
March 2024: KI Reports
https://read.qxmd.com/read/38477622/-in-silico-human-cardiomyocyte-action-potential-modeling-exploring-ion-channel-input-combinations
#18
JOURNAL ARTICLE
Emmanuel Boulay, Eric Troncy, Vincent Jacquemet, Hai Huang, Michael K Pugsley, Anne-Marie Downey, Rafael Venegas Baca, Simon Authier
In silico modeling offers an opportunity to supplement and accelerate cardiac safety testing. With in silico modeling, computational simulation methods are used to predict electrophysiological interactions and pharmacological effects of novel drugs on critical physiological processes. The O'Hara-Rudy's model was developed to predict the response to different ion channel inhibition levels on cardiac action potential duration (APD) which is known to directly correlate with the QT interval. APD data at 30% 60% and 90% inhibition were derived from the model to delineate possible ventricular arrhythmia scenarios and the marginal contribution of each ion channel to the model...
March 13, 2024: International Journal of Toxicology
https://read.qxmd.com/read/38475997/investigating-the-erg-a-wave-and-retinal-diseases-with-rod-equivalent-circuit-model-based-on-the-apd
#19
JOURNAL ARTICLE
Qing-An Ding, Chunyan Liu, Fangfang Ning, Xiaoyuan Li, Binghui Hou, Yuhua Gao, Jianyu Li, Chaoran Gu
Most empirically supported mathematical models of rod cells lack theoretical support from actual physical devices. Therefore, this paper proposes an equivalent circuit model for the rod is proposed based on the photoconductive properties of the avalanche photodetector (APD) and combined with the electrical properties of the rod. The model employs the photodetector to simulate the source of the photocurrent in outer segments of rod cells and takes into account the electrical properties of the inner and outer segments, the nucleus, and the synaptic terminals...
March 11, 2024: Biophysical Journal
https://read.qxmd.com/read/38465761/pediatric-psoriasis-associated-with-van-wyk-grumbach-syndrome-a-case-report
#20
JOURNAL ARTICLE
Asma Marzouk, Rania Mezzi, Saida Zelfani, Nour Jelaila, Saad Ayeb, Asma Bouaziz
INTRODUCTION: Psoriasis is a common chronic inflammatory condition, often beginning in childhood in approximately one-third of cases. It can be associated with various other autoimmune diseases such as rheumatoid arthritis, celiac disease, and thyroid disorders. However, its co-occurrence with Van Wyk Grumbach syndrome has not been described in the pediatric population. This syndrome, resulting from untreated hypothyroidism, is characterized by early puberty and ovarian cysts. OBSERVATION: A 15-year-old adolescent with a diagnosis of psoriasis since the age of 9 presented with chronic constipation and headaches...
October 5, 2023: La Tunisie Médicale
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