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https://www.readbyqxmd.com/read/28339208/doubly-resonant-photonic-antenna-for-single-infrared-quantum-dot-imaging-at-telecommunication-wavelengths
#1
Zhihua Xie, Yannick Lefier, Miguel Angel Suarez, Mathieu Mivelle, Roland Salut, Jean-Marc Merolla, Thierry Grosjean
Colloidal quantum dots (CQDs) have drawn strong interest in the past for their high prospects in scientific, medical, and industrial applications. However, the full characterization of these quantum emitters is currently restricted to the visible wavelengths, and it remains a key challenge to optically probe single CQDs operating in the infrared spectral domain, which is targeted by a growing number of applications. Here, we report the first experimental detection and imaging at room temperature of single infrared CQDs operating at telecommunication wavelengths...
March 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28338929/performance-tests-of-active-personal-dosemeter-developed-by-%C3%A3-nrtc-nel
#2
Dogan Yasar, Enis Kapdan, Muharrem Korkmaz
The Active personal dosemeter (APD) developed by Çekmece Nuclear Research and Training Center/Nuclear Electronic Laboratory (ÇNRTC/NEL) was calibrated at the reference radiation quality (137Cs). The performance tests were carried out with 137Cs, 60Co and X-ray beam qualities in compliance with the standards of International Organization for Standardization ISO4037-1,3 and The International Electrotechnical Commission, IEC61526:2010. Response of the personal dose equivalent was observed to be within the range from -7...
March 1, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28329466/healthcare-reform-literacy-among-academic-dermatologists-what-we-know-and-don-t-know-about-the-affordable-care-act
#3
Brian A Raphael, Suephy Chen, Benjamin Stoff
IMPORTANCE: There have been no attempts to determinethe understanding of the Affordable Care Act (ACA)among dermatologists. OBJECTIVE: Assess knowledgeof the ACA among academic dermatologists. DESIGN: A 21-item survey was administered to membersof the Association of Professors of Dermatology(APD). The items assessed knowledge and opinionsof the ACA, and demographics of the participants.Multivariate regressions were conducted todetermine associations between variables...
January 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28325860/economic-costs-of-automated-and-continuous-ambulatory-peritoneal-dialysis-in-taiwan-a-combined-survey-and-retrospective-cohort-analysis
#4
Chao-Hsiun Tang, Yu-Ting Wu, Siao-Yuan Huang, Hsi-Hsien Chen, Ming-Ju Wu, Bang-Gee Hsu, Jer-Chia Tsai, Tso-Hsiao Chen, Yuh-Mou Sue
OBJECTIVES: Taiwan succeeded in raising the proportion of peritoneal dialysis (PD) usage after the National Health Insurance (NHI) payment scheme introduced financial incentives in 2005. This study aims to compare the economic costs between automated PD (APD) and continuous ambulatory PD (CAPD) modalities from a societal perspective. DESIGN AND SETTING: A retrospective cohort of patients receiving PD from the NHI Research Database was identified during 2004-2011...
March 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28321411/different-densities-of-na-ca-exchange-current-in-t-tubular-and-surface-membranes-and-their-impact-on-cellular-activity-in-a-model-of-rat-ventricular-cardiomyocyte
#5
M Pásek, J Šimurda, G Christé
The ratio of densities of Na-Ca exchanger current (INaCa) in the t-tubular and surface membranes (INaCa-ratio) computed from the values of INaCa and membrane capacitances (Cm) measured in adult rat ventricular cardiomyocytes before and after detubulation ranges between 1.7 and 25 (potentially even 40). Variations of action potential waveform and of calcium turnover within this span of the INaCa-ratio were simulated employing previously developed model of rat ventricular cell incorporating separate description of ion transport systems in the t-tubular and surface membranes...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28300323/acquired-perforating-dermatosis-clinicopathological-study-of-31-cases-emphasizing-pathogenesis-and-treatment
#6
Ana Julia García-Malinis, Elena Del Valle Sánchez, María Pilar Sánchez-Salas, Elena Del Prado, Carmen Coscojuela, Yolanda Gilaberte
BACKGROUND: Acquired perforating dermatosis (APD) is a rare group of skin disorders of unknown aetiology and pathogenesis, and is associated with several systemic diseases. OBJECTIVE: We review the clinicopathological features, associated systemic diseases, and treatment response in a series of APD patients. METHODS: We conducted a retrospective observational study of all patients histologically diagnosed with APD in Hospital San Jorge (Huesca, Spain) between 2002 and 2014...
March 16, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28297189/pelvic-inlet-shape-is-not-as-dimorphic-as-previously-suggested
#7
Hillary Delprete
It is well known that there are significant differences in the pelves of males and females due, in part, to differing constraints. The male and female pelves must be suitable for upright posture and locomotion, but the female pelvis must also be suitable for reproduction. These differing requirements lead to differences in the shape and size of various pelvic dimensions. These differences are reflected in the pelvic inlet, midplane, and outlet. Current research has documented dimorphisms in the posterior and anterior spaces in all three of these planes...
April 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28294132/5-ht2c-agonists-modulate-schizophrenia-like-behaviors-in-mice
#8
Vladimir M Pogorelov, Ramona M Rodriguiz, Jianjun Cheng, Mei Huang, Claire M Schmerberg, Herbert Y Meltzer, Bryan L Roth, Alan P Kozikowski, William C Wetsel
All FDA-approved antipsychotic drugs (APDs) target primarily dopamine D2 or serotonin (5-HT2A) receptors, or both; however, these medications are not universally effective, they may produce undesirable side-effects, and provide only partial amelioration of negative and cognitive symptoms. The heterogeneity of pharmacological responses in schizophrenic patients suggests additional drug-targets may be effective in improving aspects of this syndrome. Recent evidence suggests that 5-HT2C receptors may be a promising target for schizophrenia since their activation reduces mesolimbic nigrostriatal dopamine release (which conveys antipsychotic action), they are expressed almost exclusively in CNS, and have weight-loss promoting capabilities...
March 15, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28290788/-the-myocardial-sleeves-of-the-pulmonary-veins-potential-implications-for-atrial-fibrillation
#9
Y V Egorov, L V Rozenshtrauh
Pulmonary veins (PVs) are thought to play an important role in the initiation of atrial fibrillation. However, systematic microelectrode studies from different regions of the left atria and PV myocardium remain limited. METHODS AND RESULTS: A 2-microelectrode technique was used to characterize electrophysiological properties of rat left atrial and PV myocardium, at baseline and during electrical stimulation. PV myocardium was characterized by prolonged action potential duration (APD) (74+/-2 ms in the PV mouth vs...
February 2017: Kardiologiia
https://www.readbyqxmd.com/read/28286635/maturational-changes-in-ear-advantage-for-monaural-word-recognition-in-noise-among-listeners-with-central-auditory-processing-disorders
#10
Mohsin Ahmed Shaikh, Lisa Fox-Thomas, Denise Tucker
This study aimed to investigate differences between ears in performance on a monaural word recognition in noise test among individuals across a broad range of ages assessed for (C)APD. Word recognition scores in quiet and in speech noise were collected retrospectively from the medical files of 107 individuals between the ages of 7 and 30 years who were diagnosed with (C)APD. No ear advantage was found on the word recognition in noise task in groups less than ten years. Performance in both ears was equally poor...
February 1, 2017: Audiology Research
https://www.readbyqxmd.com/read/28284858/inhibition-of-potassium-currents-is-involved-in-antiarrhythmic-effect-of-moderate-ethanol-on-atrial-fibrillation
#11
Baode Yang, Chenxing Li, Junyi Sun, Xinghui Wang, Xinling Liu, Chun Yang, Lina Chen, Jun Zhou, Hao Hu
Excessive consumption of alcohol is a well-established risk factor of atrial fibrillation (AF). However, the effects of moderate alcohol drinking remain to be elucidated. This study was designed to determine the effects of moderate ethanol ingestion on atrial fibrillation and the electrophysiological mechanisms. In acetylcholine-induced canine and mouse AF models, the moderate ethanol prevented the generation and persistence of AF through prolonging the latent period of AF and shortening the duration of AF...
March 9, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28283227/clozapine-as-the-most-efficacious-antipsychotic-for-activating-erk-1-2-kinases-role-of-5-ht2a-receptor-agonism
#12
Stefano Aringhieri, Shivakumar Kolachalam, Claudio Gerace, Marco Carli, Valeria Verdesca, Maria Giulia Brunacci, Chiara Rossi, Chiara Ippolito, Anna Solini, Giovanni U Corsini, Marco Scarselli
Antipsychotics (APDs) are divided into first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) based on the concept that SGAs have reduced motor side effects. With this premise, this study examined in HeLa and other cell lines the effects of different APDs on the activation of ERK1/2 (Extracellular signal-regulated kinases) and AKT (Protein Kinase B) kinases, which may be affected in schizophrenia and bipolar disorder. Among the SGAs, Clozapine clearly resulted as the most effective drug inducing ERK1/2 phosphorylation with potency in the low micromolar range...
March 7, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28270595/differential-responses-of-rabbit-ventricular-and-atrial-transient-outward-current-ito-to-the-ito-modulator-ns5806
#13
Hongwei Cheng, Mark B Cannell, Jules C Hancox
Transient outward potassium current (Ito) in the heart underlies phase 1 repolarization of cardiac action potentials and thereby affects excitation-contraction coupling. Small molecule activators of Ito may therefore offer novel treatments for cardiac dysfunction, including heart failure and atrial fibrillation. NS5806 has been identified as a prototypic activator of canine Ito This study investigated, for the first time, actions of NS5806 on rabbit atrial and ventricular Ito Whole cell patch-clamp recordings of Ito and action potentials were made at physiological temperature from rabbit ventricular and atrial myocytes...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28268303/effects-and-underlying-mechanisms-of-refractory-period-pacing-on-repolarization-dynamics-in-the-human-heart
#14
Diogo Santos, Michele Orini, Xin Zhou, Alfonso Bueno-Orovio, Ben Hanson, Peter Taggart, Martin Hayward, Blanca Rodriguez, Pier Lambiase
Repolarization alternans is related to the initiation of life threatening cardiac arrhythmias. Experimental and computational studies suggest that the abolishment of alternans using dynamic pacing protocols may prevent abnormal heart rhythms. In a recent animal study, refractory period pacing (RPP) on every other beat has shown promising results in alternans reduction. However, the cellular mechanisms underlying this therapy and its efficiency in human patients remain unclear. In this study, in vivo unipolar electrograms acquired during RPP from 240 epicardial sites from one patient were analysed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28265756/sodium-channel-biophysics-late-sodium-current-and-genetic-arrhythmic-syndromes
#15
REVIEW
Karan R Chadda, Kamalan Jeevaratnam, Ming Lei, Christopher L-H Huang
Arrhythmias arise from breakdown of orderly action potential (AP) activation, propagation and recovery driven by interactive opening and closing of successive voltage-gated ion channels, in which one or more Na(+) current components play critical parts. Early peak, Na(+) currents (I Na) reflecting channel activation drive the AP upstroke central to cellular activation and its propagation. Sustained late Na(+) currents (I Na-L) include contributions from a component with a delayed inactivation timecourse influencing AP duration (APD) and refractoriness, potentially causing pro-arrhythmic phenotypes...
March 6, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28244178/evaluation-of-an-optimized-18-f-fluoro-deoxy-glucose-positron-emission-tomography-voxel-wise-method-to-early-support-differential-diagnosis-in-atypical-parkinsonian-disorders
#16
S P Caminiti, P Alongi, L Majno, M A Volontè, C Cerami, L Gianolli, G Comi, D Perani
BACKGROUND AND PURPOSE: Atypical Parkinsonian disorders (APD) frequently overlap in clinical presentations, making the differential diagnosis challenging in the early stages. The present study aimed to evaluate the accuracy of the [(18) F]fluoro-deoxy-glucose positron emission tomography Statistical Parametric Mapping (SPM) optimized procedure in supporting the early and differential diagnosis of APD. METHODS: Seventy patients with possible APD were retrospectively included from a large clinical cohort...
February 28, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28239501/consensus-on-the-definition-of-advanced-parkinson-s-disease-a-neurologists-based-delphi-study-cepa-study
#17
Maria-Rosario Luquin, Jaime Kulisevsky, Pablo Martinez-Martin, Pablo Mir, Eduardo S Tolosa
To date, no consensus exists on the key factors for diagnosing advanced Parkinson disease (APD). To obtain consensus on the definition of APD, we performed a prospective, multicenter, Spanish nationwide, 3-round Delphi study (CEPA study). An ad hoc questionnaire was designed with 33 questions concerning the relevance of several clinical features for APD diagnosis. In the first-round, 240 neurologists of the Spanish Movement Disorders Group participated in the study. The results obtained were incorporated into the questionnaire and both, results and questionnaire, were sent out to and fulfilled by 26 experts in Movement Disorders...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28226462/effects-and-underlying-mechanisms-of-refractory-period-pacing-on-repolarization-dynamics-in-the-human-heart
#18
Diogo Santos, Michele Orini, Xin Zhou, Alfonso Bueno-Orovio, Ben Hanson, Peter Taggart, Martin Hayward, Blanca Rodriguez, Pier Lambiase, Diogo Santos, Michele Orini, Xin Zhou, Alfonso Bueno-Orovio, Ben Hanson, Peter Taggart, Martin Hayward, Blanca Rodriguez, Pier Lambiase, Ben Hanson, Diogo Santos, Martin Hayward, Pier Lambiase, Alfonso Bueno-Orovio, Blanca Rodriguez, Michele Orini, Xin Zhou, Peter Taggart
Repolarization alternans is related to the initiation of life threatening cardiac arrhythmias. Experimental and computational studies suggest that the abolishment of alternans using dynamic pacing protocols may prevent abnormal heart rhythms. In a recent animal study, refractory period pacing (RPP) on every other beat has shown promising results in alternans reduction. However, the cellular mechanisms underlying this therapy and its efficiency in human patients remain unclear. In this study, in vivo unipolar electrograms acquired during RPP from 240 epicardial sites from one patient were analysed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28221346/synthesis-of-ent-be-43547a1-reveals-a-potent-hypoxia-selective-anticancer-agent-and-uncovers-the-biosynthetic-origin-of-the-apd-cld-natural-products
#19
Nikolaj L Villadsen, Kristian M Jacobsen, Ulrik B Keiding, Esben T Weibel, Bjørn Christiansen, Thomas Vosegaard, Morten Bjerring, Frank Jensen, Mogens Johannsen, Thomas Tørring, Thomas B Poulsen
Tumour hypoxia is speculated to be a key driver of therapeutic resistance and metastatic dissemination. Consequently, the discovery of new potent agents that selectively target the hypoxic cell population may reveal new and untapped antitumour mechanisms. Here we demonstrate that the BE-43547 subclass of the APD-CLD (amidopentadienoate-containing cyclolipodepsipeptides) natural products possesses highly hypoxia-selective growth-inhibitory activity against pancreatic cancer cells. To enable this discovery, we have developed the first synthesis of the BE-43547-macrocyclic scaffold in 16 steps (longest linear sequence), which also allowed access to the full panel of relative stereoisomers and ultimately to the assignment of stereochemical configuration...
March 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28219344/origin-and-phylogenetic-status-of-the-local-ashanti-dwarf-pig-adp-of-ghana-based-on-genetic-analysis
#20
Richard Osei-Amponsah, Benjamin M Skinner, Dennis O Adjei, Julien Bauer, Greger Larson, Nabeel A Affara, Carole A Sargent
BACKGROUND: The Ashanti Dwarf Pig (ADP) of Ghana is an endangered pig breed with hardy and disease resistant traits. Characterisation of animal genetic resources provides relevant data for their conservation and sustainable use for food security and economic development. We investigated the origin and phylogenetic status of the local ADP of Ghana and their crosses with modern commercial breeds based on mtDNA, MC1R, Y-chromosome sequence polymorphisms, and genome-wide SNP genotyping. RESULTS: The study involved 164 local pigs sampled from the three agro-ecological zones of Ghana...
February 20, 2017: BMC Genomics
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