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https://www.readbyqxmd.com/read/27906285/highly-alignment-tolerant-and-high-sensitivity-100gb-s-4-%C3%A3-25gb-s-apd-rosa-with-a-thin-film-filter-based-de-multiplexer
#1
Joon Young Huh, Sae-Kyoung Kang, Jie Hyun Lee, Joon Ki Lee, SunMe Kim
We investigate and demonstrate a 100-Gb/s (4x25-Gb/s) receiver optical sub-assembly (ROSA) based on avalanche photodiodes and a thin-film filter-based de-multiplexer. The overall alignment tolerances of the ROSA are relaxed to have larger than ± 25 μm by improving optical coupling structure. The receiver sensitivity of each lane is also measured to be less than -22.2 dBm, a record minimum to our knowledge, at the bit error ratio of 10<sup>-12</sup> for 25.78-Gb/s NRZ signal.
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27904722/comparison-between-radiological-and-clinical-outcomes-of-laminoplasties-with-titanium-miniplates-for-cervical-myelopathy
#2
Jong-Hwa Park, Jae-Sung Ahn, Ho-Jin Lee, Byung-Kon Shin
BACKGROUND: Laminoplasty is a surgical procedure frequently performed for cervical myelopathy. We investigated correlations between changes in the anteroposterior diameter (APD) of the spinal canal, spinal canal area (SCA), and laminar angle (LA) and clinical outcomes of laminoplasty. METHODS: Of the 204 cervical myelopathy patients who underwent laminoplasty from July 2010 to May 2015, 49 patients who were evaluated with pre- and postoperative computed tomography of the cervical vertebrae were included...
December 2016: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/27902841/dynamical-effects-of-calcium-sensitive-potassium-currents-on-voltage-and-calcium-alternans
#3
Matthew Kennedy, Donald M Bers, Nipavan Chiamvimonvat, Daisuke Sato
Cardiac alternans is a precursor to life-threatening arrhythmias. Alternans can be caused by instability of the membrane voltage (Vm ), instability of the intracellular Ca (Cai ) cycling, or both. Vm dynamics and Cai dynamics are coupled via Ca-sensitive currents. In cardiac myocytes, there are several Ca-sensitive potassium (K) currents such as the slowly activating delayed rectifier current (IKs ) and the small conductance Ca-activated potassium (SK) current (ISK ). However, the role of these currents in the development of arrhythmias is not well understood...
November 30, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27879654/early-antipsychotic-treatment-in-juvenile-rats-elicits-long-term-alterations-to-the-dopamine-neurotransmitter-system
#4
Michael De Santis, Jiamei Lian, Xu-Feng Huang, Chao Deng
Prescription of antipsychotic drugs (APDs) to children has substantially increased in recent years. Whilst current investigations into potential long-term effects have uncovered some alterations to adult behaviours, further investigations into potential changes to neurotransmitter systems are required. The current study investigated potential long-term changes to the adult dopamine (DA) system following aripiprazole, olanzapine and risperidone treatment in female and male juvenile rats. Levels of tyrosine hydroxylase (TH), phosphorylated-TH (p-TH), dopamine active transporter (DAT), and D₁ and D₂ receptors were measured via Western blot and/or receptor autoradiography...
November 22, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27863381/probucol-prevents-atrial-ion-channel-remodeling-in-an-alloxan-induced-diabetes-rabbit-model
#5
Huaying Fu, Guangping Li, Changle Liu, Jian Li, Lijun Cheng, Wansong Yang, Gary Tse, Jichao Zhao, Tong Liu
Diabetes mellitus (DM) increases the risk of developing atrial fibrillation (AF), but the molecular mechanisms of diabetes-induced atrial remodeling processes have not been fully characterized. The aim of this study was to examine the mechanisms underlying atrial ion channel remodeling in alloxan-induced diabetes model in rabbits. A total of 40 Japanese rabbits were randomly assigned to a control group (C), alloxan-induced diabetic group (DM), probucol-treated control group (Control-P), and probucol-treated diabetic group (DM-P)...
November 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27863364/interactions-of-digitalis-and-class-iii-antiarrhythmic-drugs-amiodarone-versus-dronedarone
#6
Gerrit Frommeyer, Dirk Puckhaber, Christian Ellermann, Dirk G Dechering, Simon Kochhäuser, Patrick Leitz, Florian Reinke, Lars Eckardt
BACKGROUND: A post hoc analysis of the PALLAS trial suggested possible interactions of dronedarone and digitalis glycosides. The aim of the present study was to compare the effects dronedarone or amiodarone in combination with digitalis glycosides. METHODS AND RESULTS: Eleven female rabbits underwent chronic oral treatment with amiodarone (50mg/kg/d for 6weeks). Ten rabbits were treated with dronedarone (50mg/kg/d for 6weeks). Ten rabbits were used as controls. Hearts were isolated and Langendorff-perfused...
November 7, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27855215/distribution-of-bottom-trawling-effort-in-the-yellow-sea-and-east-china-sea
#7
Shengmao Zhang, Shaofei Jin, Heng Zhang, Wei Fan, Fenghua Tang, Shenglong Yang
Bottom trawling is one of the most efficient fishing activities, but serious and persistent ecological issues have been observed by fishers, scientists and fishery managers. Although China has applied the Beidou fishing vessel position monitoring system (VMS) to manage trawlers since 2006, little is known regarding the impacts of trawling on the sea bottom environments. In this study, continuous VMS data of the 1403 single-rig otter trawlers registered in the Xiangshan Port, 3.9% of the total trawlers in China, were used to map the trawling effort in 2013...
2016: PloS One
https://www.readbyqxmd.com/read/27844147/acute-ivabradine-treatment-reduces-heart-rate-without-increasing-atrial-fibrillation-inducibility-irrespective-of-underlying-vagal-activity-in-dogs
#8
Kazunori Uemura, Masashi Inagaki, Can Zheng, Toru Kawada, Meihua Li, Masafumi Fukumitsu, Masaru Sugimachi
Ivabradine, a bradycardic agent, has been shown to stably reduce patient's heart rate (HR) in the setting of acute cardiac care. However, an association between atrial fibrillation (AF) risk and acute ivabradine treatment remains a controversial clinical issue, and has not been thoroughly investigated. Bradycardia and abnormal atrial refractoriness induced by ivabradine treatment may enhance vulnerability to AF induction, especially when vagal nerve is concurrently activated. We aimed to experimentally investigate the effects of acute ivabradine treatment with/without concurrent vagal activation on AF inducibility...
November 14, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27831693/identification-of-mental-states-and-interpersonal-functioning-in-borderline-personality-disorder
#9
Kathy R Berenson, Cara Dochat, Christiana G Martin, Xiao Yang, Eshkol Rafaeli, Geraldine Downey
Atypical identification of mental states in the self and others has been proposed to underlie interpersonal difficulties in borderline personality disorder (BPD), yet no previous empirical research has directly examined associations between these constructs. We examine 3 mental state identification measures and their associations with experience-sampling measures of interpersonal functioning in participants with BPD relative to a healthy comparison (HC) group. We also included a clinical comparison group diagnosed with avoidant personality disorder (APD) to test the specificity of this constellation of difficulties to BPD...
November 10, 2016: Personality Disorders
https://www.readbyqxmd.com/read/27828499/thresholding-schemes-for-visible-light-communications-with-cmos-camera-using-entropy-based-algorithms
#10
Kevin Liang, Chi-Wai Chow, Yang Liu, Chien-Hung Yeh
Recent visible light communication (VLC) studies mainly used positive-intrinsic-negative (PIN) and avalanche photodiode (APD). VLC using embedded complementary-metal-oxide-semiconductor (CMOS) camera is attractive. Using the rolling shutter effect of CMOS camera can increase the VLC data rate; and different techniques have been proposed for improving the demodulation of the rolling shutter pattern. Important steps to demodulate the rolling shutter pattern are the smoothing and the application of efficient thresholding to distinguish data logic...
October 31, 2016: Optics Express
https://www.readbyqxmd.com/read/27828254/ingaas-algaassb-avalanche-photodiode-with-high-gain-bandwidth-product
#11
Shiyu Xie, Xinxin Zhou, Shiyong Zhang, David J Thomson, Xia Chen, Graham T Reed, Jo Shien Ng, Chee Hing Tan
: Increasing reliance on the Internet places greater and greater demands for high-speed optical communication systems. Increasing their data transfer rate allows more data to be transferred over existing links. With optical receivers being essential to all optical links, bandwidth performance of key components in receivers, such as avalanche photodiodes (APDs), must be improved. The APDs rely on In<sub>0.53</sub>Ga<sub>0.47</sub>As (grown lattice-matched to InP substrates) to efficiently absorb and detect the optical signals with 1310 or 1550 nm wavelength, the optimal wavelengths of operation for these optical links...
October 17, 2016: Optics Express
https://www.readbyqxmd.com/read/27827460/potent-inducers-of-endogenous-antimicrobial-peptides-for-host-directed-therapy-of-infections
#12
H Ottosson, F Nylén, P Sarker, E Miraglia, P Bergman, G H Gudmundsson, R Raqib, B Agerberth, R Strömberg
A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in a rabbit model of Shigellosis resulted in recovery from the infection in a few days implying that APD's are promising candidates for treatment of infections.
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27825745/maternal-urinary-carbohydrate-antigen-19-9-as-a-novel-biomarker-for-evaluating-fetal-hydronephrosis-a-pilot-study
#13
Abdol-Mohammad Kajbafzadeh, Sorena Keihani, Seyedeh Maryam Kameli, Asal Hojjat
OBJECTIVE: To evaluate maternal urinary CA19-9 as a potential marker for diagnosing severe antenatal hydronephrosis (ANH) during pregnancy and to compare the values with those in normal pregnancies as controls. MATERIALS & METHODS: A total of 20 women in their third pregnancy trimester were enrolled. An anteroposterior diameter (APD) of ≥15 was considered as severe ANH. Case group consisted of 10 women with a diagnosis of severe ANH. Ten women with similar age, gestational age (GA), fetal sex, normal ultrasonography, and no history of any congenital anomalies were chosen as controls...
November 4, 2016: Urology
https://www.readbyqxmd.com/read/27816985/determination-of-the-need-for-surgical-intervention-in-infants-diagnosed-with-fetal-hydronephrosis-in-china
#14
Lei Zhang, Chao Liu, Yan Li, Chao Sun, Xiang Li
BACKGROUND Hydronephrosis is a common congenital condition. The detection of fetal hydronephrosis by ultrasound presents a treatment dilemma. This study aims to examine postnatal follow-up and treatment for hydronephrosis diagnosed prenatally. MATERIAL AND METHODS This was a retrospective study of 210 infants with hydronephrosis diagnosed at the Qilu Hospital (Shangdong, China) between January 2005 and January 2013. The patient cohort was divided into four groups based on prenatal ultrasound examinations using the Society for Fetal Urology (SFU) classification system...
November 6, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27813448/early-assessment-of-pro-arrhythmic-risk-of-drugs-using-the-in-vitro-data-and-single-cell-based-in-silico-models-proof-of-concept
#15
Mitra Abbasi, Ben G Small, Nikunjkumar Patel, Masoud Jamei, Sebastian Polak
BACKGROUND AND PURPOSE: To determine the predictive performance of in silico models using drug-specific preclinical cardiac electrophysiology data to investigate drug-induced arrhythmia risk (e.g. Torsade de Pointes (TdP)) in virtual human subjects. EXPERIMENTAL APPROACH: To assess drug proarrhythmic risk, we used a set of in vitro electrophysiological measurements describing ion channel inhibition triggered by the investigated drugs. The Cardiac Safety Simulator (CSS V2...
November 4, 2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/27810276/-peritoneal-equilibration-test-conventional-versus-adapted-preliminary-study
#16
Ariane Zaloszyc, Claus Peter Schmitt, Betti Schaefer, Armelle Doutey, Joëlle Terzic, Soraya Menouer, Laetitia Higel, Michel Fischbach
Conventional automated peritoneal dialysis (APD) is prescribed as a repetition of cycles with the same dwell time and the same fill volume. Water and sodium balance remains a common problem among patients on peritoneal dialysis. More recently, adapted automated peritoneal dialysis was described, as a combination of short dwells with a low volume, in order to enhance ultrafiltration, followed by long dwells with a large fill volume to favor solute removal. We performed a preliminary crossover study on 4 patients...
October 31, 2016: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/27806581/analytically-based-photon-scatter-modeling-for-a-multipinhole-cardiac-spect-camera
#17
Amir Pourmoghaddas, R Glenn Wells
PURPOSE: Dedicated cardiac SPECT scanners have improved performance over standard gamma cameras allowing reductions in acquisition times and/or injected activity. One approach to improving performance has been to use pinhole collimators, but this can cause position-dependent variations in attenuation, sensitivity, and spatial resolution. CT attenuation correction (AC) and an accurate system model can compensate for many of these effects; however, scatter correction (SC) remains an outstanding issue...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27805004/mir-19b-regulates-ventricular-action-potential-duration-in-zebrafish
#18
Alexander Benz, Mandy Kossack, Dominik Auth, Claudia Seyler, Edgar Zitron, Lonny Juergensen, Hugo A Katus, David Hassel
Sudden cardiac death due to ventricular arrhythmias often caused by action potential duration (APD) prolongation is a common mode of death in heart failure (HF). microRNAs, noncoding RNAs that fine tune gene expression, are frequently dysregulated during HF, suggesting a potential involvement in the electrical remodeling process accompanying HF progression. Here, we identified miR-19b as an important regulator of heart function. Zebrafish lacking miR-19b developed severe bradycardia and reduced cardiac contractility...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27796808/evaluation-of-basic-characteristics-of-a-semiconductor-detector-for-personal-radiation-dose-monitoring
#19
Kento Terasaki, Toshioh Fujibuchi, Hiroo Murazaki, Taku Kuramoto, Yoshiyuki Umezu, Yang Ishigaki, Yoshinori Matsumoto
Real-time radiation dose management is important because staff members working in interventional radiology may be exposed to relatively high doses of primary and scattered radiation from the body of a patient. In this study, we investigated the dependence of energy and dose rate of the commercially available semiconductor detector named Pocket Geiger (POKEGA) for personal monitoring in diagnostic X-rays. In the energy-dependence study, a suitable metal filter and the threshold level were examined for energy compensation using a Monte Carlo calculation code...
October 28, 2016: Radiological Physics and Technology
https://www.readbyqxmd.com/read/27796576/cardiac-inotropy-lusitropy-and-ca-2-handling-with-major-metabolic-substrates-in-rat-heart
#20
Zai Hao Zhao, Jae Boum Youm, Yue Wang, Jeong Hoon Lee, Jae Hwi Sung, Joon-Chul Kim, Sun Hee Woo, Chae Hun Leem, Sung Joon Kim, Lan Cui, Yin Hua Zhang
Fatty acid (FA)-dependent oxidation is the predominant process for energy supply in normal heart. Impaired FA metabolism and metabolic insufficiency underlie the failing of the myocardium. So far, FA metabolism in normal cardiac physiology and heart failure remains undetermined. Here, we evaluate the mechanisms of FA and major metabolic substrates (termed NF) on the contraction, relaxation, and Ca(2+) handling in rat left ventricular (LV) myocytes. Our results showed that NF significantly increased myocyte contraction and facilitated relaxation...
October 28, 2016: Pflügers Archiv: European Journal of Physiology
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