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https://www.readbyqxmd.com/read/29623617/health-related-quality-of-life-in-patients-treated-with-continuous-ambulatory-peritoneal-dialysis-and-automated-peritoneal-dialysis-in-singapore
#1
F Yang, N Luo, T Lau, Z L Yu, M W Y Foo, K Griva
OBJECTIVE: This study aimed to compare the health-related quality of life (HRQOL) in patients with end-stage renal disease (ESRD) treated with continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD) in Singapore. METHODS: The data used in this study were from two cross-sectional surveys of ESRD patients. HRQOL was assessed using the Kidney Disease Quality of Life (KDQOL) instrument. Socio-demographic characteristics and clinical data were collected...
July 14, 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29621066/electrical-stimulation-based-renal-nerve-mapping-exacerbates-ventricular-arrhythmias-during-acute-myocardial-ischaemia
#2
Bing Huang, Xiaoya Zhou, Menglong Wang, Xuefei Li, Liping Zhou, Guannan Meng, Yuhong Wang, Zhuo Wang, Songyun Wang, Lilei Yu, Hong Jiang
OBJECTIVE: Blood pressure elevation in response to transient renal nerve stimulation (RNS) has been used to determine the ablation target and endpoint of renal denervation. This study aimed to evaluate the safety of transient RNS in canines with normal or ischaemic hearts. METHODS: In ten normal (Group 1) and six healed myocardial infarction (HMI) (Group 2) canines, a large-tip catheter was inserted into the left or right renal artery to perform transient RNS. The left stellate ganglion neural activity (LSGNA) and ventricular electrophysiological parameters were measured at baseline and during transient RNS...
April 4, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29610689/acquired-perforating-dermatosis-in-a-patient-on-peritoneal-dialysis-a-case-report-and-review-of-the-literature
#3
Talha H Imam, Hassan Patail, Nabeela Khan, Phillip T Hsu, David S Cassarino
Acquired perforating dermatosis (APD) is a debilitating and itchy skin disease. Its diagnosis is based on biopsy and the treatment is not very clear. It is not well established as to how wide spread it is in patients on peritoneal dialysis (PD) and its implications in this population have not been well studied. Here we present a case of APD that developed in a patient on PD. Its pathology and treatment options are reviewed. More studies are needed to assess the prevalence of APD in PD population.
2018: Case Reports in Nephrology
https://www.readbyqxmd.com/read/29610048/is-the-renal-pyramidal-thickness-a-good-predictor-for-pyeloplasty-in-postnatal-hydronephrosis
#4
Amr Hodhod, John-Paul Capolicchio, Roman Jednak, Hadeel Eid, Abd El-Alim El-Doray, Mohamed El-Sherbiny
OBJECTIVES: We evaluated the feasibility and value of renal pyramidal thickness (PT) as a predictor of pyeloplasty in high-grade postnatal hydronephrosis. PATIENTS AND METHODS: We retrospectively reviewed the charts of patients who presented with postnatal hydronephrosis from 2008 to 2013. Included cases had grade 3 or 4 hydronephrosis. We included only units diagnosed as ureteropelvic junction obstruction. Gender, laterality, hydronephrosis side, renogram data, and follow-up data were recorded...
March 20, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29603116/methylene-blue-counteracts-h-2-s-induced-cardiac-ion-channel-dysfunction-and-atp-reduction
#5
Joseph Y Cheung, JuFang Wang, Xue-Qian Zhang, Jianliang Song, John M Davidyock, Fabian Jana Prado, Santhanam Shanmughapriya, Alison M Worth, Muniswamy Madesh, Annick Judenherc-Haouzi, Philippe Haouzi
We have previously demonstrated that methylene blue (MB) counteracts the effects of hydrogen sulfide (H2 S) cardiotoxicity by improving cardiomyocyte contractility and intracellular Ca2+ homeostasis disrupted by H2 S poisoning. In vivo, MB restores cardiac contractility severely depressed by sulfide and protects against arrhythmias, ranging from bundle branch block to ventricular tachycardia or fibrillation. To dissect the cellular mechanisms by which MB reduces arrhythmogenesis and improves bioenergetics in myocytes intoxicated with H2 S, we evaluated the effects of H2 S on resting membrane potential (Em ), action potential (AP), Na+ /Ca2+ exchange current (INaCa ), depolarization-activated K+ currents and ATP levels in adult mouse cardiac myocytes and determined whether MB could counteract the toxic effects of H2 S on myocyte electrophysiology and ATP...
March 30, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29599784/disease-evolution-and-response-to-rapamycin-in-activated-phosphoinositide-3-kinase-%C3%AE-syndrome-the-european-society-for-immunodeficiencies-activated-phosphoinositide-3-kinase-%C3%AE-syndrome-registry
#6
Maria Elena Maccari, Hassan Abolhassani, Asghar Aghamohammadi, Alessandro Aiuti, Olga Aleinikova, Catherine Bangs, Safa Baris, Federica Barzaghi, Helen Baxendale, Matthew Buckland, Siobhan O Burns, Caterina Cancrini, Andrew Cant, Pascal Cathébras, Marina Cavazzana, Anita Chandra, Francesca Conti, Tanya Coulter, Lisa A Devlin, J David M Edgar, Saul Faust, Alain Fischer, Marina Garcia Prat, Lennart Hammarström, Maximilian Heeg, Stephen Jolles, Elif Karakoc-Aydiner, Gerhard Kindle, Ayca Kiykim, Dinakantha Kumararatne, Bodo Grimbacher, Hilary Longhurst, Nizar Mahlaoui, Tomas Milota, Fernando Moreira, Despina Moshous, Anna Mukhina, Olaf Neth, Benedicte Neven, Alexandra Nieters, Peter Olbrich, Ahmet Ozen, Jana Pachlopnik Schmid, Capucine Picard, Seraina Prader, William Rae, Janine Reichenbach, Stephan Rusch, Sinisa Savic, Alessia Scarselli, Raphael Scheible, Anna Sediva, Svetlana O Sharapova, Anna Shcherbina, Mary Slatter, Pere Soler-Palacin, Aurelie Stanislas, Felipe Suarez, Francesca Tucci, Annette Uhlmann, Joris van Montfrans, Klaus Warnatz, Anthony Peter Williams, Phil Wood, Sven Kracker, Alison Mary Condliffe, Stephan Ehl
Activated phosphoinositide 3-kinase (PI3K) δ Syndrome (APDS), caused by autosomal dominant mutations in PIK3CD (APDS1) or PIK3R1 (APDS2), is a heterogeneous primary immunodeficiency. While initial cohort-descriptions summarized the spectrum of clinical and immunological manifestations, questions about long-term disease evolution and response to therapy remain. The prospective European Society for Immunodeficiencies (ESID)-APDS registry aims to characterize the disease course, identify outcome predictors, and evaluate treatment responses...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29593564/dynamic-action-potential-restitution-contributes-to-mechanical-restitution-in-right-ventricular-myocytes-from-pulmonary-hypertensive-rats
#7
Matthew E L Hardy, Eleftheria Pervolaraki, Olivier Bernus, Ed White
We investigated the steepened dynamic action potential duration (APD) restitution of rats with pulmonary artery hypertension (PAH) and right ventricular (RV) failure and tested whether the observed APD restitution properties were responsible for negative mechanical restitution in these myocytes. PAH and RV failure were provoked in male Wistar rats by a single injection of monocrotaline (MCT) and compared with saline-injected animals (CON). Action potentials were recorded from isolated RV myocytes at stimulation frequencies between 1 and 9 Hz...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29582958/-ckd-mbd-in-peritoneal-dialysis
#8
Anna Rachele Rocca, Tania Gnerre Musto, Sandro Mazzaferro
CKD-MBD is a systemic disorder of the mineral and bone metabolism as a result of CKD. The clinical relevance of this syndrome has led to the identification of the biochemical targets to be achieved in order to improve the outcome of the patient. However, in hemodialysis (HD) and peritoneal dialysis (DP) patients, these targets are not reached. Hyperphosphatemia is a predictor of cardiovascular and all-cause mortality. In DP the removal of phosphorus (P) occurs by diffusion and convection, with a contribution of ultrafiltration of about 11%...
March 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29566126/electrical-dysfunctions-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-from-a-patient-with-an-arrhythmogenic-right-ventricular-cardiomyopathy
#9
Ibrahim El-Battrawy, Zhihan Zhao, Huan Lan, Lukas Cyganek, Christoph Tombers, Xin Li, Fanis Buljubasic, Siegfried Lang, Malte Tiburcy, Wolfram-Hubertus Zimmermann, Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiao-Bo Zhou, Ibrahim Akin
Aims: Our aim is to investigate the arrhythmogenic mechanism in arrhythmogenic right ventricular cardiomyopathy (ARVC)-patients by using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Methods and results: Human-induced pluripotent stem cell-derived cardiomyocytes were generated from human skin fibroblasts of two healthy donors and an ARVC-patient with a desmoglein-2 (DSG2) mutation. Patch clamp, quantitative polymerase chain reaction, and calcium imaging techniques were employed for the study...
March 16, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29563914/exhaustion-of-the-cd8-t-cell-compartment-in-patients-with-mutations-in-phosphoinositide-3-kinase-delta
#10
Marjolein W J Wentink, Yvonne M Mueller, Virgil A S H Dalm, Gertjan J Driessen, P Martin van Hagen, Joris M van Montfrans, Mirjam van der Burg, Peter D Katsikis
Pathogenic gain-of-function mutations in the gene encoding phosphoinositide 3-kinase delta (PI3Kδ) cause activated PI3Kδ syndrome (APDS), a disease characterized by humoral immunodeficiency, lymphadenopathy, and an inability to control persistent viral infections including Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infections. Understanding the mechanisms leading to impaired immune response is important to optimally treat APDS patients. Immunosenescence of CD8+ T cells was suggested to contribute to APDS pathogenesis...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29556229/respiratory-manifestations-of-the-activated-phosphoinositide-3-kinase-delta-syndrome
#11
REVIEW
Alison M Condliffe, Anita Chandra
The activated phosphoinositide 3-kinase δ syndrome (APDS), also known as p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency (PASLI), is a combined immunodeficiency syndrome caused by gain-of-function mutations in the phosphoinositide 3-kinase (PI3K) genes PIK3CD (encoding p110δ: APDS1 or PASLI-CD) and PIK3R1 (encoding p85α: APDS2 or PASLI-R1). While the disease is clinically heterogeneous, respiratory symptoms and complications are near universal and often severe...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29547274/in-silico-qt-and-apd-prolongation-assay-for-early-screening-of-drug-induced-proarrhythmic-risk
#12
Lucia Romero, Jordi Cano, Julio Gomis-Tena, Beatriz Trenor, Ferran Sanz, Manuel Pastor, Javier Saiz
Drug-induced proarrhythmicity is a major concern for regulators and pharmaceutical companies. For novel drug candidates, the standard assessment involves the evaluation of the potassium hERG channels block and the in vivo prolongation of the QT interval. However, this method is known to be too restrictive and to stop the development of potentially valuable therapeutic drugs. The aim of this work is to create an in silico tool for early detection of drug-induced proarrhythmic risk. The system is based on simulations of how different compounds affect the action potential duration (APD) of isolated endocardial, midmyocardial, and epicardial cells as well as the QT prolongation in a virtual tissue...
March 16, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29544331/composition-morphology-and-growth-of-clusters-in-a-gas-of-particles-with-random-interactions
#13
Itay Azizi, Yitzhak Rabin
We use Langevin dynamics simulations to study the growth kinetics and the steady-state properties of condensed clusters in a dilute two-dimensional system of particles that are all different (APD) in the sense that each particle is characterized by a randomly chosen interaction parameter. The growth exponents, the transition temperatures, and the steady-state properties of the clusters and of the surrounding gas phase are obtained and compared with those of one-component systems. We investigate the fractionation phenomenon, i...
March 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29544173/early-glycemia-and-mortality-in-critically-ill-septic-patients-interaction-with-insulin-treated-diabetes
#14
Fraser Magee, Michael Bailey, David V Pilcher, Johan Mårtensson, Rinaldo Bellomo
PURPOSE: To investigate the relationship between dysglycemia and hospital mortality in patients with and without a preadmission diagnosis of insulin treated diabetes mellitus (ITDM). MATERIALS AND METHODS: An observational multicentre cohort study using the ANZICS-APD database on adult patients admitted to ICU with sepsis between January 1st 2006 and December 31st 2015. Four domains of dysglycemia were investigated (highest, mean and lowest blood glucose levels and glycemic variability: the absolute difference between the highest and lowest level)...
March 3, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29543356/vital-change-for-mums-a-feasibility-study-investigating-tailored-nutrition-and-exercise-care-delivered-by-video-consultations-for-women-3-12-months-postpartum
#15
L Vincze, M E Rollo, M J Hutchesson, R Callister, C E Collins
BACKGROUND: A tailored approach to nutrition and physical activity advice can support women following childbirth in managing barriers (i.e. time and childcare) to making healthy lifestyle changes. The aim of the present study was to evaluate the implementation, acceptability and preliminary efficacy of a personally tailored nutrition and exercise programme for postpartum women delivered via video-consultations by an accredited practising dietitian (APD) and accredited exercise physiologist (AEP)...
March 15, 2018: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/29535736/activated-pi3-kinase-delta-syndrome-from-genetics-to-therapy
#16
REVIEW
David Michalovich, Sergey Nejentsev
Activated PI3 kinase delta syndrome (APDS) is a primary immunodeficiency caused by dominant mutations that increase activity of phosphoinositide-3-kinase δ (PI3Kδ). APDS can be caused by mutations in the PIK3CD gene that encodes PI3Kδ catalytic subunit p110δ (APDS1) or mutations in the PIK3R1 gene that encodes regulatory subunit p85α (APDS2). APDS research advanced rapidly after the initial discovery in 2013. More than 200 APDS patients have been identified around the world. Multiple novel APDS mutations were reported and molecular mechanisms leading to PI3Kδ activation have been elucidated...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29532845/3d-depth-profiling-of-the-interaction-between-an-afm-tip-and-fluid-polymer-solutions
#17
Martin Dehnert, Robert Magerle
In the atomic force microscopy (AFM) investigation of soft polymers and liquids, the tip-sample interaction is dominated by long-range van der Waals forces, capillary forces and adhesion. Furthermore, the tip can indent several tens of nanometres into the surface, and it can pull off a polymer filament from the surface. Therefore, measuring the unperturbed shape of a polymeric fluid can be challenging. Here, we study the tip-sample interaction with polystyrene droplets swollen in chloroform vapour, where we can utilize the solvent vapour concentration to adjust the specimen's mechanical properties from a stiff solid to a fluid film...
March 13, 2018: Nanoscale
https://www.readbyqxmd.com/read/29526032/par1-contribution-in-acute-electrophysiological-properties-of-oral-anticoagulants-in-rabbit-pulmonary-vein-sleeve-preparations
#18
Jonaz Font, Mathilda Simeon, Christophe Simard, Stéphane Allouche, Anne-Flore Plane, Virginie Ferchaud, Marie Brionne, René Rouet, Marie Nowoczyn, Alain Manrique, Paolo Emilio Puddu, Paul Milliez, Joachim Alexandre
Whether oral anti-coagulants, vitamin K antagonists (VKAs) and non-vitamin K oral anticoagulant (NOACs) frequently prescribed to atrial fibrillation (AF) patients, do themselves have a pro- or anti-arrhythmic effect have never been addressed. Transmembrane action potentials were recorded in an acute rabbit model of superfused pulmonary veins (PVs) sleeves preparations using standard microelectrode technique. Fluindione 10 μmol/L (n = 6) increased the AP (action potential) duration (APD), induced a significantly Vmax depression (from 95±14 to 53±5 V/s, P < 0...
March 11, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29522557/cardiac-electrophysiological-adaptations-in-the-equine-athlete-restitution-analysis-of-electrocardiographic-features
#19
Mengye Li, Karan R Chadda, Gareth D K Matthews, Celia M Marr, Christopher L-H Huang, Kamalan Jeevaratnam
Exercising horses uniquely accommodate 7-8-fold increases in heart rate (HR). The present experiments for the first time analysed the related adaptations in action potential (AP) restitution properties recorded by in vivo telemetric electrocardiography from Thoroughbred horses. The horses were subjected to a period of acceleration from walk to canter. The QRS durations, and QT and TQ intervals yielded AP conduction velocities, AP durations (APDs) and diastolic intervals respectively. From these, indices of active, λ = QT/(QRS duration), and resting, λ0 = TQ/(QRS duration), AP wavelengths were calculated...
2018: PloS One
https://www.readbyqxmd.com/read/29517100/biosynthesis-and-incorporation-of-an-alkylproline-derivative-apd-precursor-into-complex-natural-products
#20
REVIEW
J Janata, Z Kamenik, R Gazak, S Kadlcik, L Najmanova
Covering: up to 2017This review covers the biosynthetic and evolutionary aspects of lincosamide antibiotics, antitumour pyrrolobenzodiazepines (PBDs) and the quorum-sensing molecule hormaomycin. These structurally and functionally diverse groups of complex natural products all incorporate rarely occurring 4-alkyl-l-proline derivatives (APDs) biosynthesized from l-tyrosine through an unusual specialized pathway catalysed by a common set of six proteins named Apd1-Apd6. We give an overview of APD formation, which involves unusual enzyme activities, and its incorporation, which is based either on nonribosomal peptide synthetase (PBDs, hormaomycin) or a unique hybrid ergothioneine-dependent condensation system followed by mycothiol-dependent sulphur atom incorporation (lincosamides)...
March 8, 2018: Natural Product Reports
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