Riccardo Dore, Regina Krotenko, Jan Philipp Reising, Luca Murru, Sivaraj Mohana Sundaram, Alessandro Di Spiezio, Helge Müller-Fielitz, Markus Schwaninger, Olaf Jöhren, Jens Mittag, Maria Passafaro, Marya Shanabrough, Tamas L Horvath, Carla Schulz, Hendrik Lehnert
Homeostatic and hedonic pathways distinctly interact to control food intake. Dysregulations of circuitries controlling hedonic feeding may disrupt homeostatic mechanisms and lead to eating disorders. The anorexigenic peptides nucleobindin-2 (NUCB2)/nesfatin-1 may be involved in the interaction of these pathways. The endogenous levels of this peptide are regulated by the feeding state, with reduced levels following fasting and normalized by refeeding. The fasting state is associated with biochemical and behavioral adaptations ultimately leading to enhanced sensitization of reward circuitries towards food reward...
April 30, 2020: Neuropsychopharmacology