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https://www.readbyqxmd.com/read/28929979/pharmacists-as-care-providers-for-stroke-patients-a-systematic-review
#1
Jade E Basaraba, Michelle Picard, Kirsten George-Phillips, Tania Mysak
BACKGROUND: Pharmacists have become an integral member of the multidisciplinary team providing clinical patient care in various healthcare settings. Although evidence supporting their role in the care of patients with other disease states is well-established, minimal literature has been published evaluating pharmacist interventions in stroke patients. The purpose of this systematic review is to summarize the evidence evaluating the impact of pharmacist interventions on stroke patient outcomes...
September 20, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28927919/results-of-conservative-follow-up-or-surgical-treatment-of-mayamoya-patients-who-present-without-hemorrhage-tia-or-stroke
#2
Rutao Luo, Faliang Gao, Xiaofeng Deng, Dong Zhang, Yan Zhang
OBJECTIVE: The epidemiology of asymptomatic Moyamoya disease (MMD) is still unclear, and the best management remains controversial. The aim of this study is to evaluate the prognosis of these patients with different management, conservative follow-up or surgical treatment. METHODS: This prospective cohort study screened a series of 696 consecutive MMD patients from 2009 to 2015. Patients with any episodes of hemorrhage and ischemic stroke or TIA were excluded. Finally, 61 patients who were followed up for at least 12 months were included, with 52 patients underwent surgical treatment and 9 patients underwent conservative follow-up...
September 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28924103/pravastatin-reduces-the-risk-of-atherothrombotic-stroke-when-administered-within-six-months-of-an-initial-stroke-event
#3
Naohisa Hosomi, Yoji Nagai, Kazuo Kitagawa, Yoko Nakagawa, Shiro Aoki, Tomohisa Nezu, Tatsuo Kagimura, Hirofumi Maruyama, Hideki Origasa, Kazuo Minematsu, Shinichiro Uchiyama, Masayasu Matsumoto
AIMS: The J-STARS study examined whether pravastatin (10 mg/day) reduces recurrence of stroke in non-cardioembolic ischemic stroke patients who were enrolled within 1 month to 3 years after initial stroke events (ClinicalTrials.gov, NCT00221104). The main results showed that the frequency of atherothrombotic stroke was low in pravastatin-treated patients, although no effect of pravastatin was found for the other stroke subtypes. We evaluated differences of early (within 6 months) or late (after 6 months) pravastatin treatment benefits on the incidence of stroke or transient ischemic attack (TIA), as well as atherothrombotic stroke and the other subtypes...
September 16, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28923103/moderate-sensitivity-and-high-specificity-of-emergency-department-administrative-data-for-transient-ischemic-attacks
#4
Amy Y X Yu, Hude Quan, Andrew McRae, Gabrielle O Wagner, Michael D Hill, Shelagh B Coutts
BACKGROUND: Validation of administrative data case definitions is key for accurate passive surveillance of disease. Transient ischemic attack (TIA) is a condition primarily managed in the emergency department. However, prior validation studies have focused on data after inpatient hospitalization. We aimed to determine the validity of the Canadian 10th International Classification of Diseases (ICD-10-CA) codes for TIA in the national ambulatory administrative database. METHODS: We performed a diagnostic accuracy study of four ICD-10-CA case definition algorithms for TIA in the emergency department setting...
September 18, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28917562/an-updated-meta-analysis-of-novel-oral-anticoagulants-versus-vitamin-k-antagonists-for-uninterrupted-anticoagulation-in-atrial-fibrillation-catheter-ablation
#5
Rhanderson Cardoso, Leonardo Knijnik, Aditya Bhonsale, Guilherme Nasi, Manuel Rivera, Vanessa Blumer, Hugh Calkins
BACKGROUND: Catheter ablation is recommended as a first or second-line rhythm control therapy for selected patients with atrial fibrillation (AF). There is a wide variability in the periprocedural management of oral anticoagulation for patients undergoing AF ablation. OBJECTIVE: We aimed to perform an updated meta-analysis of novel oral anticoagulants (NOACs) vs. vitamin K antagonists (VKAs) as uninterrupted anticoagulation for patients undergoing AF ablation. METHODS: Databases and conference abstracts were searched...
September 13, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28913351/adequate-platelet-function-inhibition-confirmed-by-two-inductive-agents-predicts-lower-recurrence-of-ischemic-stroke-transient-ischemic-attack
#6
Lulu Zhang, Xiaowei Hu, Juehua Zhu, Xiuying Cai, Yan Kong, Hui Wang, Shanshan Diao, Hongru Zhao, Jianhua Jiang, Dapeng Wang, Quanquan Zhang, Yiren Qin, Wei Yue, Qi Fang
BACKGROUND: The correlation between platelet function and recurrent ischemic stroke or TIA remains uncertain. OBJECTIVE: To investigate two inductive agents to detect platelet functions and assess associations with recurrent ischemic stroke/TIA. METHOD: The study included 738 ischemic stroke/TIA patients. On days 0, 3, and 9 after antiplatelet therapy, platelet function tests were determined by maximum aggregation rate (MAR) using a PL-11 platelet function analyzer and phase matching reagents...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28902807/external-validation-of-pooled-cohort-risk-equations-to-predict-1-year-clinical-outcome-in-ischemic-stroke-patients
#7
Haiyan Li, Runhua Zhang, Gaifen Liu, Liping Liu, Yilong Wang, Yongjun Wang
BACKGROUND The present study aimed to validate the pooled cohort risk (PCR) equations in a Chinese ischemic stroke population and to explore its prognostic value in predicting stroke recurrence, coronary heart disease, and vascular death. MATERIAL AND METHODS Patients were selected from the China National Stroke Registry. The C statistic was used to examine the clinical prediction of the scores. To analyze the relevant risk factors, univariate and multivariate logistic regressions were performed. RESULTS Out of a total of 22 216 patients, 8287 patients (including 7652 acute ischemic stroke [AIS] and 635 transient ischemic attack [TIA] patients) were selected and enrolled in the study...
September 13, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28901573/validation-of-a-novel-cartoseg%C3%A2-segmentation-module-software-for-contrast-enhanced-computed-tomography-guided-radiofrequency-ablation-in-patients-with-atrial-fibrillation
#8
EDITORIAL
Hasan Imanli, Shaun Bhatty, Jean Jeudy, Yousra Ghzally, Kiddy Ume, Rama Vunnam, Refael Itah, Mati Amit, John Duell, Vincent See, Stephen Shorofsky, Timm M Dickfeld
INTRODUCTION: Visualization of left atrial (LA) anatomy using image integration modules has been associated with decreased radiation exposure and improved procedural outcome when used for guidance of pulmonary vein isolation (PVI) in atrial fibrillation (AF) ablation. We evaluated the CARTOSEG™ CT Segmentation Module (Biosense Webster, Inc.) that offers a new CT-specific semi-automatic reconstruction of the atrial endocardium. METHODS: The CARTOSEG™ CT Segmentation Module software was assessed prospectively in 80 patients undergoing AF ablation...
September 13, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28899866/subacute-endovascular-recanalization-of-symptomatic-cerebral-artery-occlusion-a-propensity-score-matched-analysis
#9
Sang Hun Lee, Dae Chul Suh, Su Hee Cho, Jae Jon Sheen, Deok Hee Lee, Jong S Kim
BACKGROUND: The interval between the onset of cerebral vessel occlusion and recanalization has been shown to be an independent predictor of poor outcomes. However, endovascular recanalization of symptomatic cerebral vessel occlusion in the subacute period has not been well documented. We investigated the safety and efficacy of subacute recanalization of occluded cerebral vessels in patients with ischemic stroke or transient ischemic attacks (TIAs). METHODS: Between 2014 and 2015, 98 patients were admitted to the emergency room for ischemic stroke or TIA with a small infarct core, which was defined as modest early ischemic change on non-contrast CT or overt diffusion-perfusion mismatch...
September 12, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28899525/restless-legs-syndrome-after-high-risk-tia-and-minor-stroke-association-with-reduced-quality-of-life
#10
Mark I Boulos, Anthony Wan, Sandra E Black, Andrew S Lim, Richard H Swartz, Brian J Murray
BACKGROUND: Restless legs syndrome (RLS) is a movement disorder that is associated with poor quality of life and depressive symptoms in the general population. Emerging evidence suggests that RLS is closely associated with cerebrovascular disease. We assessed the effect of RLS on quality of life after stroke and transient ischemic attack (TIA). METHODS: In this single-center prospective study, we recruited patients within 14 days of high-risk TIA or minor stroke...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28895771/platelet-reactivity-adjusted-antiplatelet-therapy-in-patients-with-percutaneous-coronary-intervention-a-meta-analysis-of-randomized-controlled-trials
#11
Zhenhua Xing, Liang Tang, Zhaowei Zhu, Jiabing Huang, Xiaofan Peng, Xinqun Hu
Numerous number of evidences show that high on-treatment platelet reactivity is a well-known risk factor for adverse events in patients after percutaneous coronary intervention (PCI). Controversial situations still exist regarding the effectiveness of tailoring antiplatelet therapy according to platelet function monitoring. The PubMed, Embase, and Cochrane Central databases were searched for randomized trials comparing platelet reactivity-adjusted antiplatelet therapy with conventional antiplatelet therapy in patients undergoing PCI...
September 12, 2017: Platelets
https://www.readbyqxmd.com/read/28894947/thalamic-transitory-ischemic-attacks-presenting-as-jacksonian-sensory-march
#12
Victoria Schubert, Stephan Lauxmann, Benjamin Bender, Holger Lerche
Spreading somatosensory symptoms appearing as Jacksonian sensory march are usually considered to be due to an epileptic seizure. We report on three cases in which these symptoms were caused by thalamic ischemia. Two patients presented with stereotypically recurring hemiparesthesias lasting 2-5 min that gradually spread from the face to the arm and leg on one side. A first cerebral magnetic resonance imaging including DWI was negative in both cases, whereas new thalamic infarctions appeared on repeated imaging when clinical symptoms remained...
September 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28893572/reduced-severity-of-outcome-of-recurrent-ipsilateral-transient-cerebral-ischemia-compared-with-contralateral-transient-cerebral-ischemia-in-rats
#13
Chenyu Fan, Li Zhang, Zhijie He, Peng Shao, Li Ding, Guili Wang, Wenxiu Niu, Jie Jia
BACKGROUND: To investigate whether prior transient ischemic attack (TIA) had a preconditioning effect on subsequent cerebral infarction in a rat model using middle cerebral artery occlusion (MCAO). METHODS: Thirty-six adult male Sprague-Dawley rats were divided into 3 groups: those with transient (5 minutes) left MCAO (left TIA) (n = 15), those with transient right MCAO (right TIA) (n = 15), and a sham operation group (n = 6). Seven days after the initial transient MCAO, rats in all groups underwent permanent left MCAO...
September 8, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28887378/smoking-cessation-and-outcome-after-ischemic-stroke-or-tia
#14
Katherine A Epstein, Catherine M Viscoli, J David Spence, Lawrence H Young, Silvio E Inzucchi, Mark Gorman, Brett Gerstenhaber, Peter D Guarino, Anand Dixit, Karen L Furie, Walter N Kernan
OBJECTIVE: To assess whether smoking cessation after an ischemic stroke or TIA improves outcomes compared to continued smoking. METHODS: We conducted a prospective observational cohort study of 3,876 nondiabetic men and women enrolled in the Insulin Resistance Intervention After Stroke (IRIS) trial who were randomized to pioglitazone or placebo within 180 days of a qualifying stroke or TIA and followed up for a median of 4.8 years. A tobacco use history was obtained at baseline and updated during annual interviews...
September 8, 2017: Neurology
https://www.readbyqxmd.com/read/28883846/prior-transient-ischemic-attacks-may-have-a-neuroprotective-effect-in-patients-with-ischemic-stroke
#15
Wei-Wei Wang, De-Zhe Chen, Min Zhao, Xia-Feng Yang, Dian-Rong Gong
INTRODUCTION: Although functional recovery and survival after ischemic infarction seem to improve in patients with prior transient ischemic attack (TIA), little is known about the role of characteristics of prior TIA in subsequent cerebral infarction. Thus, the objective of this study was to explore how the characteristics of prior TIA have a neuroprotective effect on patients with ischemic stroke. MATERIAL AND METHODS: A total of 221 patients admitted consecutively to a primary care center for first-ever ischemic stroke were divided into two groups on the basis of the presence or absence of prior TIAs...
August 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28883793/a-multilevel-analysis-of-real-world-variations-in-oral-anticoagulation-initiation-for-atrial-fibrillation-in-valencia-a-european-region
#16
Aníbal García-Sempere, Daniel Bejarano-Quisoboni, Julián Librero, Clara L Rodríguez-Bernal, Salvador Peiró, Gabriel Sanfélix-Gimeno
Introduction: Beyond clinical trials, clinical practice guidelines, and administrative regulation, treatment decision-making can be influenced by individual and contextual factors. Our goal was to describe variations in the patterns of initiation of anticoagulation therapy in patients with atrial fibrillation by Health Areas (HA) in the region of Valencia in Spain and to quantify the influence of the HAs on variations in treatment choice. Methods: We conducted a population-based retrospective cohort study of all atrial fibrillation patients who started treatment with oral anticoagulants between November 2011 and February 2014 in each of the region's 24 HAs...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28882227/left-atrial-fibrosis-and-risk-of-cerebrovascular-and-cardiovascular-events-in-patients-with%C3%A2-atrial-fibrillation
#17
MULTICENTER STUDY
Jordan B King, Peyman N Azadani, Promporn Suksaranjit, Adam P Bress, Daniel M Witt, Frederick T Han, Mihail G Chelu, Michelle A Silver, Joseph Biskupiak, Brent D Wilson, Alan K Morris, Eugene G Kholmovski, Nassir Marrouche
BACKGROUND: Severity of left atrial (LA) fibrosis is a strong predictor of atrial fibrillation (AF) ablation success and has been associated with a history of stroke, hypertension, and heart failure (HF). However, it is unclear whether more severe LA fibrosis independently increases the risk of major adverse cardiovascular and cerebrovascular events (MACCE) among those with AF. OBJECTIVES: The goal of this study was to evaluate the occurrence and frequency of MACCE by strata of LA fibrosis severity in patients with AF...
September 12, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28864204/soluble-form-of-receptor-for-advanced-glycation-end-products-and-incidence-of-new-cardiovascular-events-among-patients-with-cardiovascular-disease
#18
Stefan Reichert, Ulrike Triebert, Alexander Navarrete Santos, Britt Hofmann, Hans-Günter Schaller, Axel Schlitt, Susanne Schulz
BACKGROUND AND AIMS: Soluble RAGE (sRAGE) serum level could be a biomarker for atherosclerosis and subsequent diseases such as cardiovascular disease (CVD). Therefore, we wanted to investigate whether peripheral sRAGE level is associated with new cardiovascular events among patients with CVD using the Cox's regression analysis. METHODS: In this three-year longitudinal cohort study, 1002 in-patients with angiographically proven CVD were included. In 933 patients, sRAGE levels were determined by a commercial available ELISA kit at the time of baseline examination...
August 23, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28851409/mobile-phones-in-cryptogenic-stroke-patients-bringing-single-lead-ecgs-for-atrial-fibrillation-detection-mobile-af-study-protocol-for-a-randomised-controlled-trial
#19
Roderick W Treskes, Willem Gielen, Marieke J Wermer, Robert W Grauss, Anouk P van Alem, Reza Alizadeh Dehnavi, Charles J Kirchhof, Enno T van der Velde, Arie C Maan, Ron Wolterbeek, Onno M Overbeek, Martin J Schalij, Serge A Trines
BACKGROUND: Recently published randomised clinical trials indicate that prolonged electrocardiom (ECG) monitoring might enhance the detection of paroxysmal atrial fibrillation (AF) in cryptogenic stroke or transient ischaemic attack (TIA) patients. A device that might be suitable for prolonged ECG monitoring is a smartphone-compatible ECG device (Kardia Mobile, Alivecor, San Francisco, CA, USA) that allows the patient to record a single-lead ECG without the presence of trained health care staff...
August 29, 2017: Trials
https://www.readbyqxmd.com/read/28845890/long-term-aspirin-does-not-lower-risk-of-stroke-and-increases-bleeding-risk-in-low-risk-atrial-fibrillation-ablation-patients
#20
Victoria Jacobs, Heidi T May, Tami L Bair, Brian G Crandall, Michael J Cutler DO, John D Day, Charles Mallender, Jeffrey S Osborn, J Peter Weiss, T Jared Bunch
BACKGROUND: Stroke risk is a significant concern in patients with atrial fibrillation (AF). Low stroke risk patients (CHADS2 VASc 0-2) are often treated long-term with aspirin after catheter ablation. Defining the long-term risks versus benefits of aspirin therapy, after an ablation, is essential to validate this common clinical approach. METHODS: A total of 4,124 AF ablation patients undergoing their index ablation were included in this retrospective observational study...
August 28, 2017: Journal of Cardiovascular Electrophysiology
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