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https://www.readbyqxmd.com/read/29787374/evaluating-the-impact-of-the-genitourinary-multidisciplinary-tumour-board-should-every-cancer-patient-be-discussed-as-standard-of-care
#1
Kyle Scarberry, Lee Ponsky, Edward Cherullo, William Larchian, Donald Bodner, Matthew Cooney, Rodney Ellis, Gregory Maclennan, Ben Johnson, William Tabayoyong, Robert Abouassaly
INTRODUCTION: We sought to prospectively evaluate the effectiveness of the multidisciplinary tumour board (MTB) on altering treatment plans for genitourinary (GU) cancer patients. METHODS: All GU cancer patients seen at our tertiary care hospital are discussed at MTB. We prospectively collected data on adult patients discussed over a continuous, 20-month period. Physicians completed a survey prior to MTB to document their opinion on the likelihood of change in their patient's treatment plan...
May 14, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29780751/metastatic-castration-resistant-prostate-cancer-and-the-challenge-of-a-patient-with-chronic-kidney-disease-in-hemodialysis
#2
Joana Simões, Isabel Augusto, Sara Meireles, Lurdes Vendeira, Carlos Silva
At a time when the population shows increasing longevity, entities such as cancer and chronic kidney disease (CKD) are more frequently connected. In the United States, approximately 6% of the patients on hemodialysis have cancer. The challenge to manage oncologic patients with CKD in a hemodialytic program represents a great shortage of available information on the choice of the best drug, timing, dosage adjustments, dialysis method, and treatment safety. We present the case of a patient with prostate cancer and terminal CKD in hemodialysis, and the treatment sequence after the development of resistance to hormonal blockade therapy, which included docetaxel, enzalutamide, and radium-223...
April 2018: Autopsy & Case Reports
https://www.readbyqxmd.com/read/29779672/modifiable-risk-factors-to-reduce-renal-cell-carcinoma-incidence-insight-from-the-plco-trial
#3
Jonathan Gelfond, Osamah Al-Bayati, Aashish Kabra, Kevan Iffrig, Dharam Kaushik, Michael A Liss
INTRODUCTION: Identify modifiable factors contributing to renal cell carcinoma in the PCLO to target disease prevention and reduce health care costs. METHODS: The prostate, lung, colorectal, and ovarian database were queried for the primary outcome of kidney cancer. Demographics were investigated, specifically focusing on modifiable risk factors. Statistical analysis includes the Student t-test for continuous variables, chi-squared or Fisher's exact tests for dichotomous and categorical variables for bivariate analysis...
May 17, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29777523/application-of-cu-64-nodaga-psma-pet-in-prostate-cancer
#4
Sabina Sevcenco, Hans Christoph Klingler, Klaus Eredics, Alexander Friedl, Jenifer Schneeweiss, Peter Knoll, Thomas Kunit, Lukas Lusuardi, Siroos Mirzaei
INTRODUCTION: The high diagnostic potential of 64 Cu-PSMA PET-CT imaging was clinically investigated in prostate cancer patients with recurrent disease and in the primary staging of selected patients with advanced local disease. The aim of our study is to assess the uptake behavior in the clinical setting of 64Copper Prostate-Specific Membrane Antigen (64 Cu PSMA) Positron Emission Tomography/Computed Tomography (PET/CT) in prostate cancer. METHODS: A retrospective study was performed in 23 patients with intermediate, high risk and progressive disease at primary staging of prostate cancer...
May 17, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29772880/detection-of-spatial-aggregation-of-cases-of-cancer-from-data-on-patients-and-health-centres-contained-in-the-minimum-basic-data-set
#5
Pablo Fernández-Navarro, Jose-Miguel Sanz-Anquela, Angel Sánchez Pinilla, Rosario Arenas Mayorga, Carmen Salido-Campos, Gonzalo López-Abente
The feasibility of the Minimum Basic Data Set (MBDS) as a tool in cancer research was explored monitoring its incidence through the detection of spatial clusters. Case-control studies based on MBDS and marked point process were carried out with the focus on the residence of patients from the Prince of Asturias University Hospital in Alcalá de Henares (Madrid, Spain). Patients older than 39 years with diagnoses of stomach, colorectal, lung, breast, prostate, bladder and kidney cancer, melanoma and haematological tumours were selected...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29769245/pi3k-akt-mtor-signaling-pathway-and-the-biphasic-effect-of-arsenic-in-carcinogenesis
#6
Qiao Yi Chen, Max Costa
Arsenic is a naturally occurring ubiquitous metalloid found in the Earth's crust. In its inorganic form, Arsenic is highly toxic and carcinogenic, and is widely found across the globe and through out the environment. As an International Agency for Research on Cancer (IARC) defined Class I human carcinogen, arsenic has been found to cause multiple human cancers including liver, lung, urinary bladder, skin, kidney, and prostate. Mechanisms of arsenic-induced carcinogenesis remain elusive and this review specifically focuses on the role of PI3K/AKT/mTOR pathway in promoting cancer development...
May 16, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29753463/de-novo-urologic-malignancies-in-renal-transplant-recipients
#7
H Antunes, E Tavares-da-Silva, R Oliveira, J Carvalho, B Parada, C Bastos, A Figueiredo
BACKGROUND: Immunosuppressed organ transplant patients have an elevated risk of malignancies. The aim of this study was to determine the incidence of urologic malignancies in renal transplant recipients, as well as to evaluate their monitoring, treatment, and outcomes. METHODS: We conducted a retrospective single-center study of 2897 renal transplants between January 1987 and December 2016. Recipients presenting with de novo urologic malignancies were evaluated...
March 10, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29747490/health-related-quality-of-life-perceived-social-support-and-depression-in-disease-free-survivors-who-underwent-curative-surgery-only-for-prostate-kidney-and-bladder-cancer-comparison-among-survivors-and-with-the-general-population
#8
Dong Wook Shin, Hyun Sik Park, Sang Hyub Lee, Seung Hyun Jeon, Seok Cho, Seok Ho Kang, Seung Chol Park, Jong Hyock Park, Jinsung Park
Purpose: The purpose of this study was to compare health-related quality of life (HRQoL) of disease-free prostate (PC), kidney (KC), and bladder cancer (BC) survivors with that of the general population. Materials and Methods: Our study included 331 urological cancer (UC) survivors (114 PC, 108 KC, and 109 BC) aged ≥ 50 years disease-free for at least 1 year after surgery. The control group included 1,177 subjects without a history of cancer. The HRQoL was assessed using the European Organization for Research and Treatment of Cancer QLQ-C30, the Duke-UNC Functional Social Support Questionnaire, and the Patient Health Questionnaire-9...
May 4, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29738184/-correlation-between-tcm-syndrome-types-and-clinical-symptoms-of-benign-prostatic-hyperplasia-with-chronic-prostatitis
#9
Xin-Fei Huang, Ke-Qin Ning, Qing Wang, Tao Liu, Ying He, Jian-Guo Xue, Li-Qin Dai, Yong-Kang Zhu
Objective: To investigate the correlation between the syndrome types of traditional Chinese medicine (TCM) and clinical symptoms of benign prostatic hyperplasia (BPH) with chronic prostatitis (BPH-CP). METHODS: We selected 150 cases of BPH-CP in this study and divided them into 7 TCM syndrome types. Using univariate and multivariate logistic regression analyses, we studied the correlation of each TCM syndrome type with the age, disease course, prostate volume, postvoid residual urine volume (PVR), prostate-specific antigen (PSA) level, maximum urinary flow rate (Qmax), and International Prostate Symptoms Score (IPSS)...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29732010/lysyl-oxidase-family-members-in-urological-tumorigenesis-and-fibrosis
#10
REVIEW
Tao Li, Changjing Wu, Liang Gao, Feng Qin, Qiang Wei, Jiuhong Yuan
Lysyl oxidase (LOX) is an extracellular copper-dependent monoamine oxidase that catalyzes crosslinking of soluble collagen and elastin into insoluble, mature fibers. Lysyl oxidase-like proteins (LOXL), LOX isozymes with partial structural homology, exhibit similar catalytic activities. This review summarizes recent findings describing the roles of LOX family members in urological cancers and fibrosis. LOX/LOXL play key roles in extracellular matrix stability and integrity, which is essential for normal female pelvic floor function...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29726046/extracellular-vesicles-toward-a-clinical-application-in-urological-cancer-treatment
#11
REVIEW
Fumihiko Urabe, Nobuyoshi Kosaka, Takahiro Kimura, Shin Egawa, Takahiro Ochiya
Extracellular vesicles are nanometer-sized lipid membranous vesicles that are released from almost all types of cells into the extracellular space. Extracellular vesicles have gained considerable attention in the past decade, and emerging evidence suggests that they play novel roles in mediating cancer biology. Extracellular vesicles contain pathogenic components, such as proteins, DNA fragments, messenger ribonucleic acids, non-coding ribonucleic acids and lipids, all of which mediate paracrine signaling in the tumor microenvironment...
May 3, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29720853/secondary-metastatic-lesions-to-colon-and-rectum
#12
REVIEW
Michail Galanopoulos, Filippos Gkeros, Christos Liatsos, Christos Pontas, Apostolis Papaefthymiou, Nikos Viazis, Gerassimos J Mantzaris, Nikolaos Tsoukalas
Metastatic lesions of the colon are a rare clinical entity that may present difficulties in management. The incidence of these metastases appears to be increasing, as a result of physicians' greater awareness during follow-up investigations of a primary neoplasm. Furthermore, the presence of a greater proportion of these abnormalities at autopsy should be a triggering factor for further investigation for doctors dealing with colorectal oncology. Their clinical presentation may vary from asymptomatic to signs similar to those of colorectal cancer...
May 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29719490/can-gallium-68-prostate-specific-membrane-antigen-ligand-be-a-potential-radiotracer-for-renal-cortical-positron-emission-tomography-imaging
#13
Ismet Sarikaya, Abdelhamid H Elgazzar, Mahmoud A Alfeeli, Ali Sarikaya
Gallium-68 prostate-specific membrane antigen (Ga-68 PSMA) ligand (HBED-CC) is a new promising positron emission tomography (PET) tracer for prostate cancer. Intense renal parenchymal uptake is a physiologic finding on Ga-68 PSMA ligand PET images. Evaluation of kidneys in low intensity demonstrates excellent distribution of this radiotracer in renal parenchyma with excellent image quality and resolution. In this article, we present the Ga-68 PSMA ligand PET renal images of four patients with prostate cancer...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29713834/the-phenotypic-effects-of-exosomes-secreted-from-distinct-cellular-sources-a-comparative-study-based-on-mirna-composition
#14
Scott Ferguson, Sera Kim, Christine Lee, Michael Deci, Juliane Nguyen
Exosomes are nano-sized vesicles composed of lipids, proteins, and nucleic acids. Their molecular landscape is diverse, and exosomes derived from different cell types have distinct biological activities. Since exosomes are now being utilized as delivery vehicles for exogenous therapeutic cargoes, their intrinsic properties and biological effects must be understood. We performed miRNA profiling and found substantial differences in the miRNA landscape of prostate cancer (PC3) and human embryonic kidney (HEK) 293 exosomes with little correlation in abundance of common miRNAs (R2  = 0...
April 30, 2018: AAPS Journal
https://www.readbyqxmd.com/read/29710126/estimation-of-future-cancer-burden-among-rescue-and-recovery-workers-exposed-to-the-world-trade-center-disaster
#15
Ankura Singh, Rachel Zeig-Owens, William Moir, Charles B Hall, Theresa Schwartz, Madeline Vossbrinck, Nadia Jaber, Mayris P Webber, Kerry J Kelly, Viola Ortiz, Ellen Koffler, David J Prezant
Importance: Elevated rates of cancer have been reported in individuals exposed to the World Trade Center (WTC) disaster, including Fire Department of the City of New York (FDNY) rescue and recovery workers. Objective: To project the future burden of cancer in WTC-exposed FDNY rescue and recovery workers by estimating the 20-year cancer incidence. Design, Setting, and Participants: A total of 14 474 WTC-exposed FDNY employees who were cancer-free on January 1, 2012; subgroup analyses were conducted of the cohort's white male population (n = 12 374)...
April 26, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29707681/hershberger-assays-for-di-2-ethylhexyl-phthalate-and-its-substitute-candidates
#16
Hee-Su Kim, Yong-Pil Cheon, Sung-Ho Lee
In the present study, we employed Hershberger assay to determine possible androgenic or antiandrogenic activities of three di-2-ethylhexyl phthalate (DEHP) substitute candidates. The assay was carried out using immature castrated Sprague-Dawley male rats. After 7 days of the surgery, testosterone propionate (TP, 0.4 mg/kg/day) and test materials (low dose, 40 mg/kg/day; high dose, 400 mg/kg/day) were administered for 10 consecutive days by subcutaneous (s.c.) injection and oral gavage, respectively. Test materials were DEHP, 2-ethylhexyl oleate (IOO), 2-ethylhexyl stearate (IOS) and triethyl 2-acetylcitrate (ATEC)...
March 2018: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/29707117/impact-of-tobacco-smoking-on-the-risk-of-developing-25-different-cancers-in-the-uk-a-retrospective-study-of-422-010-patients-followed-for-up-to-30-years
#17
Louis Jacob, Moritz Freyn, Matthias Kalder, Konstantinos Dinas, Karel Kostev
Background: The aim of this study was to analyze the impact of tobacco smoking on the risk of developing 25 different cancers in patients followed for up to 30 years in general practices in the UK. Methods: This study included all individuals with at least one visit to one of 196 general practitioners' offices in the UK between January 1988 and December 2008 (index date). Only individuals with documented smoking status were included. Smokers and non-smokers were matched (1:1) by age, gender, index year, body mass index, and physician...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29706891/targeting-dna-methyltranferases-in-urological-tumors
#18
REVIEW
Ângela Marques-Magalhães, Inês Graça, Rui Henrique, Carmen Jerónimo
Urological cancers are a heterogeneous group of malignancies accounting for a considerable proportion of cancer-related morbidity and mortality worldwide. Aberrant epigenetic traits, especially altered DNA methylation patterns constitute a hallmark of these tumors. Nonetheless, these alterations are reversible, and several efforts have been carried out to design and test several epigenetic compounds that might reprogram tumor cell phenotype back to a normal state. Indeed, several DNMT inhibitors are currently under evaluation for therapeutic efficacy in clinical trials...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29699373/evaluating-the-oncogenic-and-tumor-suppressor-role-of-xpo5-in-different-tissue-tumor-types
#19
Munazza Khan, Zafaruddin Khan, Yaser Uddin, Sadaf Mustafa, Irfan Shaukat, Jianbo Pan, Naseruddin Höti
The miRNAs nuclear export protein XPO5 has been previously studied in several individual malignancies. In our recent study we have demonstrated that excess levels of XPO5 enhanced the proliferation of prostate cancer cells. Similarly, there are studies to support the inhibitory role of XPO5 in cancers. In order to evaluate discrepancies in the expression levels of XPO5 in differential tumor types, we quantified the expression of XPO5 using gene expression RNA-seq data for several tumor types which were independently confirmed by immunohistochemistry in multiple organs cancer tissue microarray (TMAs) experiment...
April 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29698941/computer-assisted-quantitative-assessment-of-prostatic-calcifications-in-patients-with-chronic-prostatitis
#20
Matteo Boltri, Vittorio Magri, Emanuele Montanari, Gianpaolo Perletti, Alberto Trinchieri
BACKGROUND: The aim of this study was the development of quantitative assessment of prostatic calcifications at prostatic ultrasound examination by the use of an image analyzer. MATERIALS AND METHODS: A group of 82 patients was evaluated by medical history, physical, and transrectal ultrasound examination. Patients had a urethral swab, a 4-specimen study and culture of the seminal fluid. Patients were classified according to National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health...
April 26, 2018: Urologia Internationalis
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