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https://www.readbyqxmd.com/read/29453917/comparative-chemical-investigation-and-evaluation-of-antioxidant-and-tyrosinase-inhibitory-effects-of-withania-somnifera-l-dunal-and-solanum-nigrum-l-berries
#1
Abdul Hameed, Naveed Akhtar
In the present study, berries of two different species of Solanaceae family, Withania somnifera (WS) and Solanum nigrum (SN), were extracted in methanol and then fractionated with solvents, ranging from non-polar to polar, for their phytochemical profiling and investigation of antioxidant and tyrosinase enzyme inhibition capacity. The methanolic extract and n-hexane, ethyl acetate (WSEA, SNEA) and aqueous fractions were chemically analyzed and evaluated for biological activity. Total flavonoids and total phenolics were quantified in WSEA (96...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453861/virus-like-particle-engineering-from-rational-design-to-versatile-applications
#2
REVIEW
Xuanwei Ding, Dong Liu, George Booth, Wei Gao, Yuan Lu
As mimicking natural virus structures, virus-like particles (VLPs) have evolved to become a widely accepted technology used for humans which are safe, highly efficacious and profitable. Several remarkable advantages have been achieved to revolutionize the molecule delivery for diverse applications in nanotechnology, biotechnology, and medicine. Here, we review the rational structure design, manufacturing process, functionalization strategy, and emerging applications of VLPs. The situation and challenges in the VLP engineering, the key development orientation, and future applications have been discussed...
February 17, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29453548/-big-data-from-clinical-routine
#3
REVIEW
U Mansmann
BACKGROUND: Over the past 100 years, evidence-based medicine has undergone several fundamental changes. Through the field of physiology, medical doctors were introduced to the natural sciences. Since the late 1940s, randomized and epidemiological studies have come to provide the evidence for medical practice, which led to the emergence of clinical epidemiology as a new field in the medical sciences. Within the past few years, big data has become the driving force behind the vision for having a comprehensive set of health-related data which tracks individual healthcare histories and consequently that of large populations...
February 16, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29453078/diterpenoids-from-the-roots-of-euphorbia-ebracteolata-and-their-anti-tuberculosis-effects
#4
Zhenlong Yu, Yunlong Wei, Xiangge Tian, Qiulong Yan, Qingsong Yan, Xiaokui Huo, Chao Wang, Chengpeng Sun, Baojing Zhang, Xiaochi Ma
Euphorbia ebracteolata was a natural medicine for the treatment of tuberculosis. The present work has performed the investigation of bioactive chemical substances from the roots of E. ebracteolata. Using various chromatographic techniques, 15 compounds were obtained from the roots of E. ebracteolata. On the basis of widely spectroscopic data analyses, the isolated compounds were determined to be diterpenoids, including rosane derivatives (1-12), isopimarane (13), abietane (14), and lathyrane (15), among which compounds 1-4, and 9 were undescribed previously...
February 12, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29451510/-under-reporting-of-adverse-drug-reactions-a-problem-that-also-involves-medicines-subject-to-additional-monitoring-preliminary-data-from-a-single-center-experience-on-novel-oral-anticoagulants
#5
Anna Patrignani, Giorgia Palmieri, Nino Ciampani, Vincenzo Moretti, Antonio Mariani, Lucia Racca
BACKGROUND: Spontaneous reporting system is the most widely used method by pharmacovigilance centers. Its "voluntary nature" represents the main cause of adverse drug reaction (ADR) under-reporting phenomena. The aim of this study was to point out the issue of ADR under-reporting from doctors, particularly serious ADRs and adverse reactions caused by medicinal products subject to additional monitoring, such as novel oral anticoagulants (NOACs). METHODS: Only serious ADRs were analyzed, defined as death, life-threatening ADR, hospitalization (initial or prolonged), disability (significant or permanent), congenital anomaly...
January 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29451205/optical-read-out-and-modulation-of-peripheral-nerve-activity
#6
REVIEW
Arjun K Fontaine, Hans E Anderson, John H Caldwell, Richard F Weir
Numerous clinical and research applications necessitate the ability to interface with peripheral nerve fibers to read and control relevant neural pathways. Visceral organ modulation and rehabilitative prosthesis are two areas which could benefit greatly from improved neural interfacing approaches. Therapeutic neural interfacing, or 'bioelectronic medicine', has potential to affect a broad range of disorders given that all the major organs of the viscera are neurally innervated. However, a better understanding of the neural pathways that underlie function and a means to precisely interface with these fibers are required...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29450919/looking-into-the-future-toward-advanced-3d-biomaterials-for-stem-cell-based-regenerative-medicine
#7
REVIEW
Zhongmin Liu, Mingliang Tang, Jinping Zhao, Renjie Chai, Jiuhong Kang
Stem-cell-based therapies have the potential to provide novel solutions for the treatment of a variety of diseases, but the main obstacles to such therapies lie in the uncontrolled differentiation and functional engraftment of implanted tissues. The physicochemical microenvironment controls the self-renewal and differentiation of stem cells, and the key step in mimicking the stem cell microenvironment is to construct a more physiologically relevant 3D culture system. Material-based 3D assemblies of stem cells facilitate the cellular interactions that promote morphogenesis and tissue organization in a similar manner to that which occurs during embryogenesis...
February 16, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29449876/authenticity-analyses-of-rhizoma-paridis-using-barcoding-coupled-with-high-resolution-melting-bar-hrm-analysis-to-control-its-quality-for-medicinal-plant-product
#8
Bao-Zhong Duan, Ya-Ping Wang, Hai-Lan Fang, Chao Xiong, Xi-Wen Li, Ping Wang, Shi-Lin Chen
Background: Rhizoma Paridis (Chonglou) is a commonly used and precious traditional Chinese medicine. Paris polyphylla Smith var. yunnanensis (Franch.) Hand. -Mazz. and Paris polyphylla Smith var . chinensis (Franch.) Hara are the two main sources of Chonglou under the monograph of Rhizoma Paridis in Chinese Pharmacopoeia. In the local marketplace, however, this medicine is prone to be accidentally contaminated, deliberately substituted or admixed with other species that are similar to Rhizoma Paridis in shape and color...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29449346/shikonin-suppresses-proliferation-and-induces-apoptosis-in-endometrioid-endometrial-cancer-cells-via-modulating-mir-106b-pten-akt-mtor-signaling-pathway
#9
Caimei Huang, Guohua Hu
Shikonin, a natural naphthoquinone isolated from a traditional Chinese medicinal herb, which exerts anti-cancer effects in various cancers. However, the molecular mechanisms underlying the therapeutic effects of shikonin against endometrioid endometrial cancer (EEC) have not yet been fully elucidated. Herein, we investigated anti-cancer effects of shikonin on EEC cells and explored the underlying molecular mechanism. We observed that shikonin inhibits proliferation in human EEC cell lines with in a dose-dependent manner...
February 15, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29449296/gp-and-parent-dissonance-about-the-assessment-and-treatment-of-childhood-eczema-in-primary-care-a-qualitative-study
#10
Kingsley Powell, Emma Le Roux, Jonathan Banks, Matthew J Ridd
OBJECTIVES: To compare parents' and clinicians' perspectives on the assessment and treatment of children with eczema in primary care. DESIGN: Qualitative interview study with purposive and snowball sampling and thematic analysis. SETTING: 14 general practices in the UK. PARTICIPANTS: 11 parents of children with eczema and 15 general practitioners (GPs) took part in semistructured individual interviews. RESULTS: We identified several areas of dissonance between parents and GPs...
February 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29448943/cloning-and-expression-of-the-sucrose-phosphorylase-gene-in-bacillus-subtilis-and-synthesis-of-kojibiose-using-the-recombinant-enzyme
#11
Miaomiao Wang, Jing Wu, Dan Wu
BACKGROUND: Kojibiose as a prebiotic and inhibitor of α-glucosidase exhibits potential for a wide range of applications in the food and medicine fields; however, large-scale separation and extraction of kojibiose from nature is difficult. Sucrose phosphorylase (SPase) can be used for the production of kojibiose, and currently, SPase is only heterologously expressed in E. coli, making it unsuitable for use in the food industry. However, Bacillus subtilis is generally considered to be a safe organism potentially useful for SPase expression...
February 15, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29448883/natural-frequencies-do-foster-public-understanding-of-medical-tests-comment-on-pighin-gonzalez-savadori-and-girotto-2016
#12
Michelle McDowell, Mirta Galesic, Gerd Gigerenzer
Patients and doctors often need to make decisions based on the results of medical tests. When these results are presented in the form of conditional probabilities, even doctors find it difficult to interpret them correctly. There is over 20 y of research supporting the finding that people are better able to calculate the correct positive predictive value of a test when given information in natural frequencies, as opposed to conditional probabilities. Natural frequencies are one of a few psychological tools that have made it into evidence-based medicine...
February 1, 2018: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29448088/antioxidant-activity-and-total-phenolic-content-of-ethanolic-extract-of-pomegranate-peels-juice-and-seeds
#13
Zahra Derakhshan, Margherita Ferrante, Marzieh Tadi, Farnoosh Ansari, Ali Heydari, Motahreh Sadat Hosseini, Gea Oliveri Conti, Elham Khalili Sadarabad
Pomegranate (Punica granatum L.) is extensively cultivated in Middle East especially in Iran. For centuries, this fruit has been used in Iranian herbal medicine. Pomegranate peel, seed and juice contain considerable amounts of phenolic compounds and have antioxidant activity. Pomegranate peels, juice and seeds from three regions of Natanz, Shahreza, and Doorak were obtained. Antioxidant activity, total phenolic, flavonoids, and flavonols contents of pomegranate peels, seeds and juices extracts were analyzed...
February 12, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29447984/salicin-7-sulfate-a-new-salicinoid-from-willow-and-implications-for-herbal-medicine
#14
Clarice Noleto-Dias, Jane L Ward, Alice Bellisai, Charlotte Lomax, Michael H Beale
Willow (Salix sp.) is a historically well-known herbal medicine that provided the lead compound (salicin) for the discovery of aspirin, one of the most successful plant derived drugs in human medicine. During a metabolomics screen of 86 Salix species contained in the UK National Willow Collection, we have discovered, isolated and fully characterised a new natural salicinoid - salicin-7-sulfate. This molecule may have important human pharmacological actions that need to be considered in determining the efficacy and safety of willow herbal medicines...
February 12, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29446767/clapo-syndrome-identification-of-somatic-activating-pik3ca-mutations-and-delineation-of-the-natural-history-and-phenotype
#15
Lara Rodriguez-Laguna, Kristina Ibañez, Gema Gordo, Sixto Garcia-Minaur, Fernando Santos-Simarro, Noelia Agra, Elena Vallespín, Victoria E Fernández-Montaño, Rubén Martín-Arenas, Ángela Del Pozo, Héctor González-Pecellín, Rocío Mena, Inmaculada Rueda-Arenas, María V Gomez, Cristina Villaverde, Ana Bustamante, Carmen Ayuso, Víctor L Ruiz-Perez, Julián Nevado, Pablo Lapunzina, Juan C Lopez-Gutierrez, Victor Martinez-Glez
PurposeCLAPO syndrome is a rare vascular disorder characterized by capillary malformation of the lower lip, lymphatic malformation predominant on the face and neck, asymmetry, and partial/generalized overgrowth. Here we tested the hypothesis that, although the genetic cause is not known, the tissue distribution of the clinical manifestations in CLAPO seems to follow a pattern of somatic mosaicism.MethodsWe clinically evaluated a cohort of 13 patients with CLAPO and screened 20 DNA blood/tissue samples from 9 patients using high-throughput, deep sequencing...
February 15, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29446234/a-natural-antioxidant-tannic-acid-mitigates-iron-overload-induced-hepatotoxicity-in-swiss-albino-mice-through-ros-regulation
#16
Tapasree Basu, Sourav Panja, Anil Khushalrao Shendge, Abhishek Das, Nripendranath Mandal
Tannic acid (TA), a water soluble natural polyphenol with 8 gallic acids groups, is abundantly present in various medicinal plants. Previously TA has been investigated for its antimicrobial and antifungal properties. Being a large polyphenol, TA chelates more than 1 metal. Hence TA has been explored for potent antioxidant activities against reactive oxygen species (ROS), reactive nitrogen species (RNS) and as iron chelator in vitro thereby mitigating iron-overload induced hepatotoxicity in vivo. Iron dextran was injected intraperitoneally in Swiss albino mice to induce iron-overload triggered hepatotoxicity, followed by oral administration of TA for remediation...
February 15, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29445618/comparative-oncology-integrating-human-and-veterinary-medicine
#17
REVIEW
Faheem Sultan, Bilal Ahmad Ganaie
Cancer constitutes the major health problem both in human and veterinary medicine. Comparative oncology as an integrative approach offers to learn more about naturally occurring cancers across different species. Canine models have many advantages as they experience spontaneous disease, have many genes similar to human genes, five to seven-fold accelerated ageing compared to humans, respond to treatments similarly as humans do and health care levels second only to humans. Also, the clinical trials in canines could generate more robust data, as their spontaneous nature mimics real-life situations and could be translated to humans...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29445417/bioactive-polysaccharides-from-natural-resources-including-chinese-medicinal-herbs-on-tissue-repair
#18
REVIEW
Qiu Li, Yiming Niu, Panfei Xing, Chunming Wang
Background: Functional polysaccharides can be derived from plants (including herbs), animals and microorganisms. They have been widely used in a broad of biomedical applications, such as immunoregulatory agents or drug delivery vehicles. In the past few years, increasing studies have started to develop natural polysaccharides-based biomaterials for various applications in tissue engineering and regenerative medicine. Main body: We discuss in this article the emerging applications of natural polysaccharides-particularly those derived from Chinese medicine-for wound healing...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29445390/approaches-and-recent-developments-for-the-commercial-production-of-semi-synthetic-artemisinin
#19
REVIEW
Stephanie H Kung, Sean Lund, Abhishek Murarka, Derek McPhee, Chris J Paddon
The antimalarial drug artemisinin is a natural product produced by the plant Artemisia annua . Extracts of A. annua have been used in Chinese herbal medicine for over two millennia. Following the re-discovery of A. annua extract as an effective antimalarial, and the isolation and structural elucidation of artemisinin as the active agent, it was recommended as the first-line treatment for uncomplicated malaria in combination with another effective antimalarial drug (Artemisinin Combination Therapy) by the World Health Organization (WHO) in 2002...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29445343/medicinal-plants-from-near-east-for-cancer-therapy
#20
REVIEW
Mohammad S Abu-Darwish, Thomas Efferth
Background: Cancer is one of the major problems affecting public health worldwide. As other cultures, the populations of the Near East rely on medicinal herbs and their preparations to fight cancer. Methods: We compiled data derived from historical ethnopharmacological information as well as in vitro and in vivo results and clinical findings extracted from different literature databases including (PubMed, Scopus, Web of Science, and Google Scholar) during the past two decades. Results: In this survey, we analyzed the huge amount of data available on anticancer ethnopharmacological sources used in the Near East...
2018: Frontiers in Pharmacology
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