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https://www.readbyqxmd.com/read/29054871/engineering-the-enantioselectivity-and-thermostability-of-a-%C3%AE-lactamase-from-microbacterium-hydrocarbonoxydans-for-the-kinetic-resolution-of-vince-lactam
#1
Shuaihua Gao, Shaozhou Zhu, Rong Huang, Hongxia Li, Hao Wang, Guojun Zheng
To produce promising biocatalysts, natural enzymes often need to be engineered to increase their catalytic performance. In this study, the enantioselectivity and thermostability of a (+)-γ-lactamase from Microbacterium hydrocarbonoxydans as the catalyst in the kinetic resolution of Vince lactam were improved. Enantiomerically pure (-)-Vince lactam is the key synthon in the synthesis of antiviral drugs such as carbovir and abacavir, which are used to fight against human HIV and hepatitis B viruses. The work was initialized by using the combinatorial active-site saturation test strategy to engineer the enantioselectivity of the enzyme...
October 20, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29054343/aster-yomena-extract-ameliorates-pro-inflammatory-immune-response-by-suppressing-nf-%C3%AE%C2%BAb-activation-in-raw-264-7-cells
#2
Kyung-A Hwang, Yu-Jin Hwang, Jin Song
BACKGROUND: Aster yomena, an edible vegetable, is a perennial herb found in Korea, China, Japan, and Siberia. It is used as folk medicine to treat cough, bronchial asthma, and insect bites. A. yomena was recently shown to have antioxidant and anti-asthmatic activities. Studies have not yet evaluated the anti-inflammatory effects of the various solvent fractions of A. yomena. We investigated the anti-inflammatory activity of various solvent fractions (hexane, dichloromethane, ethyl acetate, and butanol) from ethanol extract of A...
October 18, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29054134/thymus-derived-mesenchymal-stem-cells-for-tissue-engineering-clinical-grade-cardiovascular-grafts
#3
Dominga Iacobazzi, Megan Swim, Ambra Albertario, Massimo Caputo, Mohamed T Ghorbel
Mesenchymal stem cells (MSCs) are attractive tools for regenerative medicine because of their multi-differentiation potential and immunomodulation capacity. In congenital heart defect surgical correction, replacement grafts lacking growth potential are commonly used. Tissue engineering promises to overcome the limitations of these grafts. In this study, we hypothesized that human thymus derived MSCs are a suitable tool to tissue engineer a living vascular graft with good integration and patency once implanted in vivo...
October 20, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29052456/population-density-analysis-for-determining-the-protonation-state-of-the-catalytic-dyad-in-bace1-tertiary-carbinamine-based-inhibitor-complex
#4
Carlos Gueto-Tettay, Luis Pelaez-Bedoya, Juan Carlos Drosos-Ramirez
BACE1 is an aspartyl protease with a very relevant role in medicinal chemistry related to Alzheimer Disease since it has demonstrated to be a promising therapeutic target for inhibition and possible control for the progress of the peptide accumulation characteristic of this pathology. The enzymatic activity of this protein is given by the aspartic dyad, Asp93 and Asp289, which can adopt several protonation states depending on the chemical nature of its inhibitors, this is, monoprotonated, diprotonated and di-deprotonated states...
October 20, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29052407/-individualized-clinical-treatment-from-the-prospective-of-hepatotoxicity-of-non-toxic-traditional-chinese-medicine
#5
Nan Yang, Juan Chen, Xue-Feng Hou, Jie Song, Liang Feng, Xiao-Bin Jia
Traditional Chinese medicine has a long history in clinical application, and been proved to be safe and effective. In recent years, the toxicity and side-effects caused by the western medicine have been attracted much attention. As a result, increasing people have shifted their attention to traditional Chinese medicine. Nonetheless, due to the natural origin of traditional Chinese medicine and the lack of basic knowledge about them, many people mistakenly consider the absolute safety of traditional Chinese medicine, except for well-known toxic ones, such as arsenic...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29052382/-research-progresses-and-formulation-development-of-natural-anti-mildew-agents-based-on-chinese-herbal-medicines
#6
REVIEW
Hai-Wei Wang, Guang-Yao Ying, Zhi-Xin Yang, Mei-Hua Yang, Jia-Jia Liu, Zhuo-Wen Fan, Wei-Jun Kong
Owing to the intrinsic factors and some extrinsic environmental conditions, many foods, agricultural products and Chinese materia medicas (CMMs), if not handled properly in the processes of growth, harvesting, processing and storage, can be easily contaminated by all kinds of molds to produce mycotoxins of serious toxicity, which will not only affect the quality, safety and effectiveness of CMMs, but also result in potential threatens to human and animal's health and life. Therefore, in recent decades, it has become the focus on how to prevent and control the foods, agricultural products and CMMs from being moldy and producing toxicity for scientific preservation...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29051632/preservation-of-orange-juice-using-propolis
#7
Wenchao Yang, Zhenhong Wu, Zachary Y Huang, Xiaoqing Miao
Orange juice is one of the most popular and the most consumed fruit juices all over the world, especially in Europe and the chemical food preservatives, such as sodium benzoate, potassium sorbate and their mixtures, have long been used in orange juice sold on the market. Excessive consumption of these preservatives may be hazardous to human health. Propolis, composed of resins collected from plant buds and exudates and mixed with salivary gland secretions and beeswax by honey bee workers, has been used as a human medicine and natural food preservative...
October 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29051102/isolation-structural-characterization-and-bioactivities-of-naturally-occurring-polysaccharide-polyphenolic-conjugates-from-medicinal-plants-a-reivew
#8
REVIEW
Jun Liu, Ruyu Bai, Yunpeng Liu, Xin Zhang, Juan Kan, Changhai Jin
In recent years, several medicinal plants have been demonstrated as valuable resources of naturally occurring polysaccharide-polyphenolic conjugates. For the first time, this article introduces recent advances of polysaccharide-polyphenolic conjugates isolated from different medicinal plants. The isolation, purification, structural characterization and biological activities of polysaccharide-polyphenolic conjugates are introduced in details. In general, polysaccharide-polyphenolic conjugates can be isolated by hot water or alkaline extraction followed by purification through anion exchange chromatography or gel filtration chromatography...
October 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29051097/production-of-low-molecular-weight-soluble-yeast-%C3%AE-glucan-by-an-acid-degradation-method
#9
Yuina Ishimoto, Ken-Ichi Ishibashi, Daisuke Yamanaka, Yoshiyuki Adachi, Ken Kanzaki, Yoichiro Iwakura, Naohito Ohno
β-glucan is widely distributed in nature as water soluble and insoluble forms. Both forms of β-glucan are utilized in several fields, especially for functional foods. Yeast β-glucan is a medically important insoluble particle. Solubilization of yeast β-glucan may be valuable for improving functional foods and in medicinal industries. In the present study, we applied an acid degradation method to solubilize yeast β-glucan and found that β-glucan was effectively solubilized to low-molecular weight β-glucans by 45% sulfuric acid treatment at 20°C...
October 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29050275/alisol-b-23-acetate-induces-autophagic-dependent-apoptosis-in-human-colon-cancer-cells-via-ros-generation-and-jnk-activation
#10
Yueliang Zhao, Edmund T S Li, Mingfu Wang
Alisol B 23-acetate (AB23A), a natural triterpenoid from the rhizome of Alisma orientale, a Chinese medicinal herb, has multiple physiological activities including anticancer. However, its effect on human colon cancer and the underlying mechanism are not clear. Here, we reported for the first time that AB23A induced cell cycle G1 phase arrest and apoptotic cell death in colon cancer cells. Autophagy also occurred in AB23A-treated HCT116 cells as evidenced by the accumulation of microtubule-associated protein 1 light chain 3 form II (LC3-II) and degradation of SQSTM1/p62...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29048849/-preparation-and-evaluation-of-hydrophilic-interaction-reversed-phase-mixed-mode-chromatographic-packing-based-on-polylsilsesquioxane-microspheres
#11
Qiannan Lü
Hydrophilic interaction (HILIC)/reversed-phase (RPLC) mixed-mode chromatography is widely used in separating both hydrophobic and hydrophilic compounds, but its pH range is limited which is harmful to the separation of alkaline drugs. Monodispersed and porous cysteine-modified vinyl functionalized polymethylsilsesquioxane (C-V-PMSQ) microspheres were prepared by thiol-ene click chemistry. Elemental analysis revealed that cysteine was successfully bonded to the surface of microspheres. C-V-PMSQ microspheres had excellent monodispersity, favorable chemical stability and simple preparation process...
September 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048641/baicalein-inhibits-tumor-progression-by-inhibiting-tumor-cell-growth-and-tumor-angiogenesis
#12
Yang-Gyu Park, Jawun Choi, Hye-Kang Jung, Bumseok Kim, Chan Kim, Sang-Youel Park, Jae-Won Seol
Baicalein, a herbal medicine, is a natural flavonoid isolated from the roots of Scutellaria baicalensis Georgi. It is known for its anticancer, anti-inflammatory and neuroprotective properties. Despite these well-known properties, it is not yet clear what effect baicalein has on tumor progression. Therefore, in the present study, we used B16F10 cells, Lewis lung carcinoma (LLC) cells, and human umbilical vein endothelial cells (HUVECs) to investigate the effect of baicalein on cell proliferation and viability, migration and tube formation in vitro...
September 26, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29048419/a-cross-sectional-quantitative-analysis-of-the-natural-history-of-farber-disease-an-ultra-orphan-condition-with-rheumatologic-and-neurological-cardinal-disease-features
#13
Matthias Zielonka, Sven F Garbade, Stefan Kölker, Georg F Hoffmann, Markus Ries
PurposeFarber disease (OMIM 22800) is an ultrarare progressive multisystemic neurodevelopmental storage disorder caused by a deficiency of the lysosomal enzyme acid ceramidase (AC). Hard clinical end points for future clinical trials remain to be defined.MethodsWe quantitatively analyzed published cases with Farber disease (N = 96). The main outcome variables were survival and diagnostic delay. As a potential predictor of survival, the influence of residual AC enzyme activity was investigated. The analysis was performed in compliance with STROBE criteria...
October 19, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29048340/helping-health-services-to-meet-the-needs-of-young-people-with-chronic-conditions-towards-a-developmental-model-for-transition
#14
REVIEW
Albert Farre, Janet E McDonagh
The transition to adult healthcare has been the subject of increased research and policy attention over many years. However, unmet needs of adolescent and young adults (AYAs) and their families continue to be documented, and universal implementation has yet to be realised. Therefore, it is pertinent to re-examine health transition in light of the principles of adolescent medicine from which it emerged, and consider this particular life transition in terms of a developmental milestone rather than a negotiation of structural boundaries between child and adult services...
October 19, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29047339/exploring-the-evidence-base-for-how-people-with-dementia-and-their-informal-carers-manage-their-medication-in-the-community-a-mixed-studies-review
#15
Lydia Aston, Andrea Hilton, Tiago Moutela, Rachel Shaw, Ian Maidment
BACKGROUND: Little is known about the general medicines management issues for people with dementia living in the community. This review has three aims: firstly to explore and evaluate the international literature on how people with dementia manage medication; assess understanding of medicines management from an informal carers perspective; and lastly to understand the role that healthcare professionals play in assisting this population with medicines management. METHODS: A mixed studies review was conducted...
October 18, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29047086/natural-antioxidants-as-potential-therapy-and-a-promising-role-for-melatonin-against-pulmonary-hypertension
#16
Gerald J Maarman
Plasma and serum samples, and lung/heart tissue of pulmonary hypertension (PH) patients and animal models of PH display elevated oxidative stress. Moreover, the severity of PH and levels of oxidative stress increase concurrently, which suggests that oxidative stress could be utilized as a biomarker for PH progression. Accumulating evidence has well established that oxidative stress is also key role player in the development of PH. Preclinical studies have demonstrated that natural antioxidants improved PH condition, and, therefore, antioxidant therapy has been proposed as a potential therapeutic strategy against PH...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29047025/targeting-the-ubiquitin-proteasome-system-for-cancer-treatment-discovering-novel-inhibitors-from-nature-and-drug-repurposing
#17
Claire L Soave, Tracey Guerin, Jinbao Liu, Q Ping Dou
In the past 15 years, the proteasome has been validated as an anti-cancer drug target and 20S proteasome inhibitors (such as bortezomib and carfilzomib) have been approved by the FDA for the treatment of multiple myeloma and some other liquid tumors. However, there are shortcomings of clinical proteasome inhibitors, including severe toxicity, drug resistance, and no effect in solid tumors. At the same time, extensive research has been conducted in the areas of natural compounds and old drug repositioning towards the goal of discovering effective, economical, low toxicity proteasome-inhibitory anti-cancer drugs...
October 18, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/29046711/effect-of-methanol-extract-of-salviae-miltiorrhizae-radix-in-high-fat-diet-induced-hyperlipidemic-mice
#18
Chiyeon Lim, Sehyun Lim, Byoungho Lee, Buyeo Kim, Suin Cho
BACKGROUND: The dried root of Salvia miltiorrhiza, Salviae miltiorrhizae Radix (SR), is one of the most popular medicinal herbs in Asian countries such as China and Korea. In Asian traditional medicine, SR is considered to have a bitter flavor, be slightly cold in nature, and exert therapeutic actions in the heart and liver meridians. Thus, SR has been used to control symptoms related to cardiovascular diseases. Hyperlipidemia is recognized as the main cause of cerebrovascular and heart diseases; consequently, therapeutic strategies for hyperlipidemia have been widely studied...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/29045746/identification-of-natural-products-as-inhibitors-of-human-organic-anion-transporters-oat1-and-oat3-and-their-protective-effect-on-mercury-induced-toxicity
#19
Xue Wang, Lifeng Han, Gentao Li, Wei Peng, Xiumei Gao, Curtis D Klaassen, Guanwei Fan, Youcai Zhang
Mercury accumulates in kidneys and produces acute kidney injury. Semen cassiae (SC), a widely consumed tea and herbal medicine in Eastern Asia, has been reported to have protective effects on kidneys. In this study, SC extract was shown to almost abolish the histological alterations induced by mercuric chloride (HgCl2) in rat kidneys. A total of 22 compounds were isolated from SC, and 1,7,8-methoxyl-2-hydroxyl-3-methyl-anthraquinone was detected in SC for the first time. Among the 8 compounds identified in the blood of rats after SC treatment, 6 were strong inhibitors of human organic anion transporter 1 and 3 (OAT1 and OAT3)...
October 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29044437/a-novel-dihydrocoumarin-under-experimental-and-theoretical-characterization
#20
W F Vaz, J M F Custodio, N M N Rodrigues, L G Santin, S S Oliveira, R Gargano, F A P Osório, G L B Aquino, A J Camargo, M S Oliveira, H B Napolitano
Coumarins are natural and synthetic active ingredients widely applied in diverse types of medicinal treatments, such as cancer, inflammation, infection, and enzyme inhibition (monoamine oxidase B). Dihydrocoumarin compounds are of great interest in organic chemistry due to their structural versatilities and, as part of our investigations concerning the structural characterization of small molecules, this work focuses on crystal structure and spectroscopic characterization of the synthesized and crystallized compound 4-(4-methoxyphenyl)-3,4-dihydro-chromen-2-one (C16H14O3)...
October 18, 2017: Journal of Molecular Modeling
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