Dayoon Kwon, Keren Zhang, Kimberly C Paul, Aline D Folle, Irish Del Rosario, Jonathan P Jacobs, Adrienne M Keener, Jeff M Bronstein, Beate Ritz
It has been suggested that gut microbiota influence Parkinson's disease (PD) via the gut-brain axis. Here, we examine associations between diet and gut microbiome composition and its predicted functional pathways in patients with PD. We assessed gut microbiota in fecal samples from 85 PD patients in central California using 16S rRNA gene sequencing. Diet quality was assessed by calculating the Healthy Eating Index 2015 (HEI-2015) based on the Diet History Questionnaire II. We examined associations of diet quality, fiber, and added sugar intake with microbial diversity, composition, taxon abundance, and predicted metagenomic profiles, adjusting for age, sex, race/ethnicity, and sequencing platform...
April 22, 2024: NPJ Parkinson's Disease