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Y Dickstein, R Edelman, T Dror, K Hussein, Y Bar-Lavie, M Paul
OBJECTIVES: To examine whether carbapenem-resistant Enterobacteriaceae (CRE) carriage is associated with incidence of clinical infection as a means of assessing whether the morbidity and mortality associated with these bacteria are mediated by underlying conditions or intrinsic properties of CRE. METHODS: This retrospective matched cohort study compared the incidence of invasive infections in CRE-colonized patients and matched non-carriers in the intensive care unit (ICU)...
September 2016: Journal of Hospital Infection
Tina Janamian, Lisa Crossland, Claire L Jackson
Value co-creation redresses a key criticism of researcher-driven approaches to research - that researchers may lack insight into the end users' needs and values across the research journey. Value co-creation creates, in a step-wise way, value with, and for, multiple stakeholders through regular, ongoing interactions leading to innovation, increased productivity and co-created outcomes of value to all parties - thus creating a "win more-win more" environment. The Centre of Research Excellence (CRE) in Building Primary Care Quality, Performance and Sustainability has co-created outcomes of value that have included robust and enduring partnerships, research findings that have value to end users (such as the Primary Care Practice Improvement Tool and the best-practice governance framework), an International Implementation Research Network in Primary Care and the International Primary Health Reform Conference...
April 18, 2016: Medical Journal of Australia
David D Schmidt, Sue Kirby
INTRODUCTION: A lack of support structures in rural and remote Australia has led to limitations in the ability of health services to develop research skills in their staff and to conduct research within their organisations. Distance, limited access to research expertise and a lack of established research networks are examples of structural contributors to limited research training and research activity. METHODS: To address this issue the Centre for Research Excellence in Rural and Remote Primary Health Care Research (CRE) established a Research Capacity Building Program (RCBP) in 2012...
January 2016: Rural and Remote Health
Jessica Tischendorf, Rafael Almeida de Avila, Nasia Safdar
BACKGROUND: Carbapenem-resistant Enterobacteriaceae (CRE) have emerged as important health care-associated pathogens. Colonization precedes infection but the risk of developing infection amongst those colonized with CRE is not clear. METHODS: We searched multiple databases for studies reporting rates of CRE-colonized patients subsequently developing infection. RESULTS: Ten studies fulfilled our inclusion criteria, including 1,806 patients used in our analysis...
May 1, 2016: American Journal of Infection Control
Ashley Taylor, Wenwen Tang, Emanuela M Bruscia, Ping-Xia Zhang, Aiping Lin, Peter Gaines, Dianqing Wu, Stephanie Halene
Serum response factor (SRF) is a ubiquitously expressed transcription factor and master regulator of the actin cytoskeleton. We have previously shown that SRF is essential for megakaryocyte maturation and platelet formation and function. Here we elucidate the role of SRF in neutrophils, the primary defense against infections. To study the effect of SRF loss in neutrophils, we crossed Srf(fl/fl) mice with select Cre-expressing mice and studied neutrophil function in vitro and in vivo. Despite normal neutrophil numbers, neutrophil function is severely impaired in Srf knockout (KO) neutrophils...
May 8, 2014: Blood
Michael Horn, Reto Baumann, Jorge A Pereira, Páris N M Sidiropoulos, Christian Somandin, Hans Welzl, Claudia Stendel, Tessa Lühmann, Carsten Wessig, Klaus V Toyka, João B Relvas, Jan Senderek, Ueli Suter
Studying the function and malfunction of genes and proteins associated with inherited forms of peripheral neuropathies has provided multiple clues to our understanding of myelinated nerves in health and disease. Here, we have generated a mouse model for the peripheral neuropathy Charcot-Marie-Tooth disease type 4H by constitutively disrupting the mouse orthologue of the suspected culprit gene FGD4 that encodes the small RhoGTPase Cdc42-guanine nucleotide exchange factor Frabin. Lack of Frabin/Fgd4 causes dysmyelination in mice in early peripheral nerve development, followed by profound myelin abnormalities and demyelination at later stages...
December 2012: Brain: a Journal of Neurology
Maryla Krajewska, Zerong You, Juan Rong, Christina Kress, Xianshu Huang, Jinsheng Yang, Tiffany Kyoda, Ricardo Leyva, Steven Banares, Yue Hu, Chia-Hung Sze, Michael J Whalen, Leonardo Salmena, Razqallah Hakem, Brian P Head, John C Reed, Stan Krajewski
BACKGROUND: Acute brain injury is an important health problem. Given the critical position of caspase 8 at the crossroads of cell death pathways, we generated a new viable mouse line (Ncasp8(-/-)), in which the gene encoding caspase 8 was selectively deleted in neurons by cre-lox system. METHODOLOGY/PRINCIPAL FINDINGS: Caspase 8 deletion reduced rates of neuronal cell death in primary neuronal cultures and in whole brain organotypic coronal slice cultures prepared from 4 and 8 month old mice and cultivated up to 14 days in vitro...
2011: PloS One
Mitchell J Schwaber, Boaz Lev, Avi Israeli, Ester Solter, Gill Smollan, Bina Rubinovitch, Itamar Shalit, Yehuda Carmeli
BACKGROUND: During 2006, Israeli hospitals faced a clonal outbreak of carbapenem-resistant Klebsiella pneumoniae that was not controlled by local measures. A nationwide intervention was launched to contain the outbreak and to introduce a strategy to control future dissemination of antibiotic-resistant bacteria in hospitals. METHODS: In March 2007, the Ministry of Health issued guidelines mandating physical separation of hospitalized carriers of carbapenem-resistant Enterobacteriaceae (CRE) and dedicated staffing and appointed a professional task force charged with containment...
April 1, 2011: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
George Jarad, Jeffrey W Pippin, Stuart J Shankland, Jordan A Kreidberg, Jeffrey H Miner
Dystroglycan (DG or DAG1) is considered a critical link between the basement membrane and the cytoskeleton in multiple tissues. DG consists of two subunits, an extracellular α-subunit that binds laminin and other basement membrane components, and a transmembrane β-subunit. DG-null mouse embryos die during early embryogenesis because DG is required for Reichert's membrane formation. DG also forms an integral part of the dystrophin-glycoprotein complex in muscle. Although no human DG mutations have been reported, multiple forms of muscular dystrophy have been linked to DG glycosylation defects, and targeted deletion of muscle DG causes muscular dystrophy in mice...
March 2011: American Journal of Physiology. Renal Physiology
Lawrence E Ostrowski, Weining Yin, Troy D Rogers, Katie B Busalacchi, Michael Chua, Wanda K O'Neal, Barbara R Grubb
Studies of primary ciliary dyskinesia (PCD) have been hampered by the lack of a suitable animal model because disruption of essential ciliary genes in mice results in a high incidence of lethal hydrocephalus. To develop a viable mouse model for long-term studies of PCD, we have generated a transgenic mouse line in which two conserved exons of the mouse intermediate dynein chain gene, Dnaic1, are flanked by loxP sites (Dnaic1(flox/flox)). Dnaic1 is the murine homolog of human DNAI1, which is mutated in approximately 10% of human PCD cases...
July 2010: American Journal of Respiratory Cell and Molecular Biology
S K Field, D P Conley, A M Thawer, R Leigh, R L Cowie
BACKGROUND: The value of other health care professionals is increasingly being recognized to compensate for the shortage of physicians in Canada. Chronic cough is one of the most common reasons for consultation with a respirologist. In the present study, a prospective, randomized, controlled study was undertaken to determine whether Certified Respiratory Educators (CREs) could manage screened patients with chronic cough as effectively as respirologists. METHODS: An eight-week, prospective, parallel-design, randomized, controlled trial of the management of chronic cough patients was conducted...
March 2009: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
Stephen K Field, Diane P Conley, Amin M Thawer, Richard Leigh, Robert L Cowie
BACKGROUND: The role of certified respiratory educators (CREs) is to educate, assess, and help to manage patients with asthma and COPD in Canada. This study was undertaken to see whether CREs could assist pulmonologists (MDs) in managing patients with chronic cough. METHODS: An 8-week prospective, parallel design, randomized, controlled trial to determine whether CREs using a protocol-driven algorithmic approach could assist in the management of patients referred to a university tertiary care medical center for the assessment and treatment of chronic cough...
October 2009: Chest
Takashi Yamaguchi, Taeko Ichise, Osamu Iwata, Akiko Hori, Tomomi Adachi, Masaru Nakamura, Nobuaki Yoshida, Hirotake Ichise
Endothelial cells are indispensable components of the vascular system, and play pivotal roles during development and in health and disease. Their properties have been studied extensively by in vivo analysis of genetically modified mice. However, further analysis of the molecular and cellular phenotypes of endothelial cells and their heterogeneity at various developmental stages, in vascular beds and in various organs has often been hampered by difficulties in culturing mouse endothelial cells. In order to overcome these difficulties, we developed a new transgenic mouse line expressing the SV40 tsA58 large T antigen (tsA58T Ag) under the control of a binary expression system based on Cre/loxP recombination...
May 2008: FEBS Journal
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