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Atherosclerosis pathology

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https://www.readbyqxmd.com/read/29152608/galectin-3-and-venous-thromboembolism-incidence-the-atherosclerosis-risk-in-communities-aric-study
#1
Oluwaseun E Fashanu, Susan R Heckbert, David Aguilar, Paul N Jensen, Christie M Ballantyne, Saonli Basu, Ron C Hoogeveen, Christopher deFilippi, Mary Cushman, Aaron R Folsom
Background: The inflammatory biomarker galectin-3 contributes to pathologic conditions such as heart failure and stimulates murine thrombogenesis. Its association with venous thromboembolism (VTE) has been sparsely studied. Objectives: To assess the prospective association of plasma galectin-3 and the LGALS3 rs4644 SNP with VTE incidence. Methods: We measured plasma galectin-3 in 9,916 participants in the Atherosclerosis Risk in Communities (ARIC) study cohort in 1996 - 1998 and identified VTEs through 2013...
October 2017: Res Pract Thromb Haemost
https://www.readbyqxmd.com/read/29141575/the-protective-effects-of-extra-virgin-olive-oil-on-immune-mediated-inflammatory-responses
#2
Rosa Casas, Ramon Estruch, Emilio Sacanella
BACKGROUND AND OBJECTIVE: The increasing interest in the Mediterranean diet (MeDiet) hinges on the relevant role it plays in inflammatory diseases. Several clinical, epidemiological and experimental evidences suggest that consumption of the MeDiet reduces the incidence of certain pathologies related to oxidative stress, chronic inflammation and immune system diseases such as cancer, atherosclerosis and cardiovascular disease (CVD). DISCUSSION: These reductions can be partially attributed to extra virgin olive oil (EVOO) consumption which has been described as a key bioactive food because of its high nutritional quality and its particular composition of fatty acids, vitamins and polyphenols...
November 13, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29137923/the-pdgf-pdgfr-pathway-as-a-drug-target
#3
REVIEW
Natalia Papadopoulos, Johan Lennartsson
Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration, primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed in a wide array of pathological conditions, such as cancer, fibrosis, neurological conditions and atherosclerosis. Reported abnormalities of the PDGF pathway include overexpression or amplification of PDGF receptors (PDGFRs), gain of function point mutations or activating chromosomal translocations. Current development of therapeutic drugs often aims at producing compounds that specifically target interaction between PDGFs and their receptors by specific DNA aptamers and ligand traps, or downregulate PDGFRs with blocking antibodies, or inhibit tyrosine kinase activity of PDGFRs with small molecules...
November 11, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/29118467/the-light-and-shadow-of-senescence-and-inflammation-in-cardiovascular-pathology-and-regenerative-medicine
#4
REVIEW
Laura Iop, Eleonora Dal Sasso, Leonardo Schirone, Maurizio Forte, Mariangela Peruzzi, Elena Cavarretta, Silvia Palmerio, Gino Gerosa, Sebastiano Sciarretta, Giacomo Frati
Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised tissue abilities to protect the heart against stress. At the molecular level, in fact, a gradual weakening of the cellular processes regulating cardiovascular homeostasis occurs in aging cells. Atherosclerosis and heart failure are particularly correlated with aging-related cardiovascular senescence, that is, the inability of cells to progress in the mitotic program until completion of cytokinesis...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29118325/the-mammalian-target-of-rapamycin-and-dna-methyltransferase-1-axis-mediates-vascular-endothelial-dysfunction-in-response-to-disturbed-flow
#5
Yun-Peng Zhang, Yi-Tao Huang, Tse-Shun Huang, Wei Pang, Juan-Juan Zhu, Yue-Feng Liu, Run-Ze Tang, Chuan-Rong Zhao, Wei-Juan Yao, Yi-Shuan Li, Shu Chien, Jing Zhou
The earliest atherosclerotic lesions preferentially develop in arterial regions experienced disturbed blood flow, which induces endothelial expression of pro-atherogenic genes and the subsequent endothelial dysfunction. Our previous study has demonstrated an up-regulation of DNA methyltransferase 1 (DNMT1) and a global hypermethylation in vascular endothelium subjected to disturbed flow. Here, we determined that DNMT1-specific inhibition in arterial wall ameliorates the disturbed flow-induced atherosclerosis through, at least in part, targeting cell cycle regulator cyclin A and connective tissue growth factor (CTGF)...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29118310/manifestation-of-coronary-atherosclerosis-in-klang-valley-malaysia-an-autopsy-study
#6
Razuin Rahimi, Mansharan Kaur Chainchel Singh, Norizal Mohd Noor, Effat Omar, Shahidan Md Noor, Mohd Shah Mahmood, Nurliza Abdullah, Hapizah Mohd Nawawi
AIMS: The present study aimed to determine the epidemiological aspects of medico-legal autopsies and manifestation of coronary atherosclerosis. METHODS: This was a cross sectional study involving 222 cases recruited from National Institute of Forensic Medicine (NIFM) Hospital Kuala Lumpur (HKL) and Department of Forensic Medicine Hospital Sungai Buloh (HSgB) for a period of 15 months, from December 2012 to April 2014. Sociodemographic and autopsy findings, including the cause and manner of death were documented...
November 8, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29115493/mir-92a-regulates-the-expression-levels-of-matrix-metalloproteinase-9-and-tissue-inhibitor-of-metalloproteinase-3-via-sirtuin-1-signaling-in-hydrogen-peroxide-induced-vascular-smooth-muscle-cells
#7
Peng Liu, Jianfang Su, Xixi Song, Shixiao Wang
Vascular smooth muscle cells (VSMCs) exhibit a notably increased rate of migration, which is one of the most common pathological changes in atherosclerosis. Investigations into the role of micro (mi)RNAs in the regulation of VSMC migration are beginning to emerge and additional miRNAs involved in VSMC migration modulation require identification. In the current study, VSMCs were primarily cultured from rat thoracic aortas, transfected with miR‑92a mimics and induced by hydrogen peroxide (H2O2) for 24 h. Total mRNA and protein were collected for quantitative polymerase chain reaction and western blot analysis...
November 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29112932/anti-atherosclerotic-effect-of-longxuetongluo-capsule-in-high-cholesterol-diet-induced-atherosclerosis-model-rats
#8
J M Zhou, H M Wang, Y Z Lv, Z Z Wang, W Xiao
Chinese dragon's blood, the red resin of Dracaena cochinchinensis, one of the famous traditional medicines, has been used to promote blood circulation, disperse blood stasis, stop bleeding, relieve pain and muscle regeneration for thousands of years. The aims of this study were to evaluate the anti-atherosclerotic effect of Longxuetongluo Capsule (LTC), which made by total phenolic compounds of Chinese dragon's blood, in high cholesterol diet (HCD)-induced atherosclerosis model rats and explore the possible mechanism...
November 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29110146/atherosclerosis-periodontal-disease-and-treatment-with-resolvins
#9
REVIEW
James A Hamilton, Hatice Hasturk, Alpdogan Kantarci, Charles N Serhan, Thomas Van Dyke
PURPOSE OF REVIEW: This review aims to discuss the existing evidence on the link between atherosclerosis and periodontitis by particularly presenting new findings that link the pathology and therapy of these diseases. Acute vascular ischemic events that can lead to stroke or myocardial infarction are initiated by inflammatory processes leading to rupture or erosion of plaques susceptible to thrombosis ("high risk" or "vulnerable"). These are highly inflamed plaques residing in the media and adventitia that may not be detected by angiography measurments of luminal narrowing...
November 6, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29108620/preface-pathology-and-pharmacology-of-atherosclerosis
#10
EDITORIAL
Amanda C Foks, Ilze Bot
No abstract text is available yet for this article.
December 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29107848/treated-hypothyroidism-is-associated-with-cerebrovascular-disease-but-not-alzheimer-s-disease-pathology-in-older-adults
#11
Willa D Brenowitz, Fang Han, Walter A Kukull, Peter T Nelson
Thyroid hormone disease is common among older adults and is associated with cognitive impairment. However, pathologic correlates are not well understood. We studied pathologic and clinical factors associated with hypothyroidism, the most common manifestation of thyroid disease, in research subjects seen annually for clinical evaluations at U.S. Alzheimer's Disease Centers. Thyroid disease and treatment status were assessed during clinician interviews. Among autopsied subjects, there were 555 participants with treated hypothyroidism and 2146 without known thyroid disease; hypothyroidism was associated with severe atherosclerosis (odds ratio: 1...
November 3, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29105622/the-effects-of-t-helper-17-and-regulatory-t-cells-on-patients-with-carotid-atherosclerosis
#12
Bo Wang, Xiaopeng Wang, Huifang Sun, Lili Hu, Jianbo Gao
This study was aimed to observe the level of T helper 17 (Th17) cells and CD4(+) CD25(+) Foxp(3+) regulatory T cells (Tregs) and their related factors in carotid atherosclerosis (AS) patients and AS model rats to explore the influence of Th17 on the pathological process of AS and its specific mechanism. 60 cases with AS in our hospital from July 2012 to July 2014 were recruited for this study as the observation group, and 40 healthy people who came to the hospital for a physical examination were the control group...
September 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29099707/hyperhomocysteinemia-as-a-predictor-of-cardiovascular-diseases-in-lead-exposed-subjects
#13
О Karlova, A Grinzovskyy, O Kuzminska, I Karvatsky
Homocysteine is independent risk factors for the development of cardiovascular diseases, such as atherosclerosis and hypertension. Therefore, the aim of our study was to establish the relationship between the concentration of lead in the blood of patients who were in contact with this heavy metal at work and clinical manifestations. The subjects of the study were 203 men 38 to 47 years old. The main group consisted of 146 people who were in direct contact with lead at work (cable network repair), the control group was 57 people (engineers and technicians)...
October 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29098831/-effect-of-dracocephalum-moldavica-total-flavones-on-expression-of-tgf-%C3%AE-1-smad-signaling-pathway-and-matrix-metalloproteinase-of-atherosclerosis-apoe-mice
#14
Yang Liu, Yi-Ning Quan, Xin-Chun Wang, Xin-Hong Guo, Yong Yuan, Wen-Jiang Cao, Jiang Cheng
To investigate the effect and mechanism of Dracocephalum moldovica total flavones (TFDM) on the formation of atherosclerosis ApoE-/- mice induced by high fat diet. A total of 40 SPF 8-week-old male ApoE-/- mice were fed with high fat diet and randomly divided into 5 groups. TFDM high, medium, low-dose group were given 21, 42, 84 mg•kg⁻¹•d⁻¹ by gavage; Simvastatin group was fed with simvastatin 3.5 mg•kg⁻¹•d⁻¹; and model group was given the same dose of normal saline. The other eight male C57BL/6J mice of the same genetic background and age were set up as control group and fed with common diet...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29097819/mechanisms-of-plasminogen-activator-inhibitor-1-action-in-stromal-remodeling-and-related-diseases
#15
Jelena Milenkovic, Maja Milojkovic, Tatjana Jevtovic Stoimenov, Boris Djindjic, Edita Miljkovic
Plasminogen activator inhibitor type 1 (PAI-1) is the main physiologic inhibitor of fibrinolysis. However, it is also involved in many physiological processes such as extracellular matrix (ECM) proteolysis and remodeling, cell adhesion, motility, and apoptosis, angiogenesis, etc. The aim of the study was to summarize current knowledge and gain insights into the mechanisms of PAI-1 action in the processes of stromal remodeling and diseases with considerable matrix pathologies (atherosclerosis, tissue fibrosis, cancer metastasis, pregnancy related complications, etc)...
November 2, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29096844/dysregulation-of-the-cd4-t-cells-lineage-differentiation-in-dyslipidemic-patients-and-impact-of-lipoprotein-apheresis-treatment-a-case-study
#16
J Papin, A Brennand, G Arbore, B Hohenstein, V Kamvissi, C Kemper, S R Bornstein
BACKGROUND AND AIM: Lipoprotein-apheresis (LA) is a therapeutic approach used against severe forms of dyslipidemia in patients who are non-responders or intolerant to pharmacological treatments. However, little is known about the potential pleiotropic effects of LA, particularly regarding the immune system and its regulation. Thus, in an attempt to analyse the potential effects of dyslipidemia and LA on the regulation of CD4(+) T cells activation and lineage differentiation, we compared the CD4(+) T cells cytokines secretion profiles of dyslipidemic patients before and after LA with the profiles observed in healthy donors...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29093498/modeling-cadmium-induced-endothelial-toxicity-using-human-pluripotent-stem-cell-derived-endothelial-cells
#17
Ling Tang, Jun Su, Ping Liang
Cadmium (Cd) is a harmful heavy metal that results in vascular diseases such as atherosclerosis. Prior evidence revealed that Cd induced endothelial cell (EC) death and dysfunction, supporting that ECs are a primary target of Cd-induced toxicity, and can cause severe pathologies of vascular diseases. However, the underlying mechanisms remain unclear. In this study, we investigated the mechanisms of Cd-induced endothelial toxicity in a human model system of H9 human pluripotent stem cell-derived endothelial cells (H9-ECs)...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29093277/the-coronary-artery-running-pattern-is-one-of-the-causes-of-individual-differences-in-the-progression-of-coronary-atherosclerosis-in-whhlmi-rabbits-an-animal-model-for-coronary-atherosclerosis
#18
Ryosuke Nagasaka, Tomonari Koike, Norie Tsukada, Shohei Tamura, Masashi Shiomi
AIMS: The relationship between the coronary artery running pattern and development of coronary lesions was re-examined herein using WHHLMI rabbits, an animal model of spontaneous coronary atherosclerosis. METHODS: The coronary artery running pattern was analyzed using an X-ray computed tomography (CT) apparatus after perfusion. Pathological sections were prepared (Victoria blue-HE staining) at 100 µm intervals from the origin of the left circumflex artery (LCX)...
November 1, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29091892/nitric-oxide-bioavailability-dysfunction-involves-in-atherosclerosis
#19
REVIEW
Jing-Yi Chen, Zi-Xin Ye, Xiu-Fen Wang, Jian Chang, Mei-Wen Yang, Hua-Hua Zhong, Fen-Fang Hong, Shu-Long Yang
The pathological characteristics of atherosclerosis (AS) include lipid accumulation, fibrosis formation and atherosclerotic plaque produced in artery intima, which leads to vascular sclerosis, lumen stenosis and irritates the ischemic changes of corresponding organs. Endothelial dysfunction was closely associated with AS. Nitric oxide (NO) is a multifunctional signaling molecule involved in the maintenance of metabolic and cardiovascular homeostasis. NO is also a potent endogenous vasodilator and enters for the key processes that suppresses the formation vascular lesion even AS...
October 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29083949/lipid-mediators-in-the-regulation-of-endothelial-barriers
#20
Pratap Karki, Konstantin G Birukov
Lipid mediators play a critical role in the development and resolution of vascular endothelial barrier dysfunction caused by various pathologic interventions. The accumulation of excess lipids directly impairs endothelial cell (EC) barrier function that is known to contribute to the development of atherosclerosis and metabolic disorders such as obesity and diabetes as well as chronic inflammation in the vascular endothelium. Certain products of phospholipid oxidation (OxPL) such as fragmented phospholipids generated during oxidative and nitrosative stress show pro-inflammatory potential and cause endothelial barrier dysfunction...
October 2, 2017: Tissue Barriers
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