keyword
MENU ▼
Read by QxMD icon Read
search

Migration

keyword
https://www.readbyqxmd.com/read/28222435/extracorporal-shock-waves-activate-migration-proliferation-and-inflammatory-pathways-in-fibroblasts-and-keratinocytes-and-improve-wound-healing-in-an-open-label-single-arm-study-in-patients-with-therapy-refractory-chronic-leg-ulcers
#1
Ilknur Aschermann, Seema Noor, Sascha Venturelli, Tobias Sinnberg, Christian Busch, Christian D Mnich
BACKGROUND/AIMS: Chronic leg ulcers (CLUs) are globally a major cause of morbidity and mortality with increasing prevalence. Their treatment is highly challenging, and many conservative, surgical or advanced therapies have been suggested, but with little overall efficacy. Since the 1980s extracorporal shock wave therapy (ESWT) has gained interest as treatment for specific indications. Here, we report that patients with CLU showed wound healing after ESWT and investigated the underlying molecular mechanisms...
February 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28222426/knockdown-of-pd-l1-in-human-gastric-cancer-cells-inhibits-tumor-progression-and-improves-the-cytotoxic-sensitivity-to-cik-therapy
#2
Jing Li, Lujun Chen, Yuqi Xiong, Xiao Zheng, Quanqin Xie, Qi Zhou, Liangrong Shi, Changping Wu, Jingting Jiang, Haitao Wang
: Background/Abstract: PD-L1 has been an important target of cancer immunotherapy. We have showed that in human gastric cancer tissues, over-expression of PD-L1 was significantly associated with cancer progression and patients' postoperative prognoses. However, as of now, how PD-L1 regulates the biological function of gastric cancer cells still remains elusive. METHODS: We constructed the stable PD-L1 knockdown expression gastric cancer cell lines by using RNAi method, and further investigated the changes of biological functions including cell viability, migration, invasion, cell cycle, apoptosis, tumorigenicity in vivo, and the cytotoxic sensitivity to CIK therapy, in contrast to the control cells...
February 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28222208/effect-of-thiolated-glycosaminoglycans-on-the-behavior-of-breast-cancer-cells-toward-the-development-of-in-vitro-models-of-cancer
#3
Alexander Köwitsch, Ankur Chhalotre, Thomas Groth
PURPOSE: The influence of extracellular matrix components like glycosaminoglycans (GAG) or adhesive proteins on the migration of cancer cells and the progression of tumorigenesis remains a challenging task. Therefore, this study aims to give insight into the interaction of cancer cells exhibiting different metastatic potential (MDA-MB-231, MDA-MB-468) with surface immobilized GAG interacting with serum proteins like fibronectin. METHODS: Model substrata were covalently coated with different thiolated GAG (hyaluronan (HA), chondroitin sulfate (CS), heparin (Hep)) and investigated for the adsorption of fibronectin (FN) with surface plasmon resonance...
February 18, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28222179/seed-and-peel-essential-oils-obtained-from-campomanesia-adamantium-fruit-inhibit-inflammatory-and-pain-parameters-in-rodents
#4
Danieli Zuntini Viscardi, Jucicléia da Silva Arrigo, Camila de Azevedo Chaves Correia, Cândida Aparecida Leite Kassuya, Claudia Andrea Lima Cardoso, Iriani Rodrigues Maldonade, Eliana Janet Sanjinez Argandoña
Campomanesia adamantium (Myrtaceae) is popularly known as "gabiroba" and has been used in folk medicine as antirheumatic, antidiarrheal, hypocholesterolemic and anti-inflammatory. This study evaluated the anti-inflammatory and antinociceptive activities and toxicology of essential oils from peel (EOP) and seed (EOS) of C. adamantium fruits in animal models. Different groups were treated with doses of 100 and 300 mg/kg and the inflammatory parameters were evaluated in carrageenan induced paw oedema and leukocyte migration in pleurisy model, while antinociceptive activity was evaluated using formalin method in rodents...
2017: PloS One
https://www.readbyqxmd.com/read/28222169/decellularized-wharton-s-jelly-from-human-umbilical-cord-as-a-novel-3d-scaffolding-material-for-tissue-engineering-applications
#5
Sushma Jadalannagari, Gabriel Converse, Christopher McFall, Eric Buse, Michael Filla, Maria T Villar, Antonio Artigues, Adam J Mellot, Jinxi Wang, Michael S Detamore, Richard A Hopkins, Omar S Aljitawi
In tissue engineering, an ideal scaffold attracts and supports cells thus providing them with the necessary mechanical support and architecture as they reconstruct new tissue in vitro and in vivo. This manuscript details a novel matrix derived from decellularized Wharton's jelly (WJ) obtained from human umbilical cord for use as a scaffold for tissue engineering application. This decellularized Wharton's jelly matrix (DWJM) contained 0.66 ± 0.12 μg/mg sulfated glycosaminoglycans (GAGs), and was abundant in hyaluronic acid, and completely devoid of cells...
2017: PloS One
https://www.readbyqxmd.com/read/28222163/investigating-human-geographic-origins-using-dual-isotope-87sr-86sr-%C3%AE-18o-assignment-approaches
#6
Jason E Laffoon, Till F Sonnemann, Termeh Shafie, Corinne L Hofman, Ulrik Brandes, Gareth R Davies
Substantial progress in the application of multiple isotope analyses has greatly improved the ability to identify nonlocal individuals amongst archaeological populations over the past decades. More recently the development of large scale models of spatial isotopic variation (isoscapes) has contributed to improved geographic assignments of human and animal origins. Persistent challenges remain, however, in the accurate identification of individual geographic origins from skeletal isotope data in studies of human (and animal) migration and provenance...
2017: PloS One
https://www.readbyqxmd.com/read/28222159/the-role-of-spatial-mobility-in-malaria-transmission-in-the-brazilian-amazon-the-case-of-porto-velho-municipality-rond%C3%A3-nia-brazil-2010-2012
#7
Jussara Rafael Angelo, Tony Hiroshi Katsuragawa, Paulo Chagastelles Sabroza, Lino Augusto Sander de Carvalho, Luiz Hildebrando Pereira da Silva, Carlos Afonso Nobre
BACKGROUND: This study aims to describe the role of mobility in malaria transmission by discussing recent changes in population movements in the Brazilian Amazon and developing a flow map of disease transmission in this region. METHODOLOGY/PRINCIPAL FINDINGS: This study presents a descriptive analysis using an ecological approach on regional and local scales. The study location was the municipality of Porto Velho, which is the capital of Rondônia state, Brazil...
2017: PloS One
https://www.readbyqxmd.com/read/28222148/microrna-200a-silencing-protects-neural-stem-cells-against-cerebral-ischemia-reperfusion-injury
#8
Ji Ma, Shaofeng Shui, Xinwei Han, Dong Guo, Tengfei Li, Lei Yan
Neural stem cells (NSCs) play major roles in neurological recovery after cerebral infarction (CI). This study was trying to investigate whether miR-200a, a vital regulator in cell proliferation, migration and apoptosis, also has a role in oxygen-glucose deprivation/reperfusion (OGD/R) injured NSCs. In this study, primary NSCs were subjected to OGD/R conditions to mimic an in vitro CI model. Before OGD/R induction, NSCs were transfected with vector or shRNA against miR-200a to overexpress or suppress miR-200a expression...
2017: PloS One
https://www.readbyqxmd.com/read/28222068/inhibition-of-cdk5-induces-cell-death-of-tumor-initiating-cells
#9
Melanie M Mandl, Siwei Zhang, Melanie Ulrich, Elisa Schmoeckel, Doris Mayr, Angelika M Vollmar, Johanna Liebl
BACKGROUND: Tumour-initiating cells (TICs) account for chemoresistance, tumour recurrence and metastasis, and therefore represent a major problem in tumour therapy. However, strategies to address TICs are limited. Recent studies indicate Cdk5 as a promising target for anti-cancer therapy and Cdk5 has recently been associated with epithelial-mesenchymal transition (EMT). However, a role of Cdk5 in TICs has not been described yet. METHODS: Expression of Cdk5 in human cancer tissue was analysed by staining of a human tissue microarray (TMA)...
February 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28221776/the-horizon-of-materiobiology-a-perspective-on-material-guided-cell-behaviors-and-tissue-engineering
#10
Yulin Li, Yin Xiao, Changsheng Liu
Although the biological functions of cell and tissue can be regulated by biochemical factors (e.g., growth factors, hormones), the biophysical effects of materials on the regulation of biological activity are receiving more attention. In this Review, we systematically summarize the recent progress on how biomaterials with controllable properties (e.g., compositional/degradable dynamics, mechanical properties, 2D topography, and 3D geometry) can regulate cell behaviors (e.g., cell adhesion, spreading, proliferation, cell alignment, and the differentiation or self-maintenance of stem cells) and tissue/organ functions...
February 21, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28221761/ultrasmall-superbright-neodymium-upconversion-nanoparticles-via-energy-migration-manipulation-and-lattice-modification-808-nm-activated-drug-release
#11
Yan Zhang, Zhongzheng Yu, Jingqiu Li, Yanxiao Ao, Jingwen Xue, Zhiping Zeng, Xiangliang Yang, Timothy Thatt Yang Tan
Nd(3+)-sensitized upconversion nanoparticles are amongst the most promising emerging fluorescent nanotransducers. They are activated by 808 nm irradiation, which features merits such as limited tissue overheating and deeper penetration depth, hence attractive for diagnostic and therapeutic applications. Recent studies indicate that ultrasmall nanoparticles (<10 nm) are potentially more suitable for clinical application due to their favorable biodistribution and safety profiles. However, upconversion nanoparticles in the sub-10 nm range suffer from poor luminescence due to their ultrasmall size and greater proportion of lattice defects...
February 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28221760/hydrogel-nanocomposites-with-independently-tunable-rheology-and-mechanics
#12
Shimon Unterman, Lyndon F Charles, Sara E Strecker, Denis Kramarenko, Dmitry Pivovarchik, Elazer Reuven Edelman, Natalie Artzi
Hydrogels are an attractive class of biomaterials for minimally invasive local drug delivery given their injectability, tunability, high water content, and biocompatibility. Broad applicability though is challenged: relatively modest mechanical properties restricts use to soft tissues, while flow properties necessary for injectability limit implantation to dried, enclosed tissues to minimize material migration during gelation. To address these dual concerns we designed an injectable nanocomposite hydrogel based on dextran aldehyde and poly(amido amine) dendrimer doped with phyllosilicate nanoplatelet fillers...
February 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28221678/validated-capillary-electrophoretic-method-for-the-enantiomeric-quality-control-of-r-praziquantel
#13
Zoltán-István Szabó, Réka Gál, Levente Szőcs, Róbert Ludmerczki, Daniela-Lucia Muntean, Béla Noszál, Gergő Tóth
The enantiomers of praziquantel, the drug of choice in schistosomiasis, were separated by electrokinetic chromatography with cyclodextrins. Nine anionic cyclodextrins were screened for their ability to discriminate between the uncharged enantiomers. Seven investigated selectors presented chiral interactions with the enantiomers, these cases being interpreted in terms of stability constants and complex mobilities. The best results were delivered by sulfated-β-cyclodextrin, where quasi-equal stability constants were accompanied by extreme selectivity values and was explained on the basis of highly different mobilities of the transient diastereomeric complexes...
February 21, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28221381/enhanced-photocatalytic-activities-of-single-crystalline-znga2o4-nanoprisms-by-the-coexposed-111-and-110-facets
#14
Tingting Zheng, Yuguo Xia, Xiuling Jiao, Ting Wang, Dairong Chen
Facet-control has been a fascinating method for preparation of highly active photocatalysts. Herein, we report the hydrothermal preparation of single-crystalline ZnGa2O4 nanoprisms with the {111} and {110} facets coexposed. Studies of their photocatalytic performance have revealed that the as-formed nanoprisms exhibit significantly enhanced photocatalytic activities compared with ZnGa2O4 nanocubes with only the {100} facets exposed and nanosheets with the {110} facets exposed for H2 evolution and contaminant degradation...
February 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28221319/analysis-of-2011-physician-assistant-education-debt-load
#15
Miranda A Moore, Megan Coffman, James F Cawley, Diana Crowley, Anthony Miller, Kathleen Klink
This study seeks to investigate how physician assistants (PAs) finance their education and to characterize the educational debt of PA students. Data from the 2011 American Academy of PAs (AAPA)-Physician Assistant Education Association Graduating Student Survey were used to explore the educational debt of PA students. The median total educational debt of a PA student graduating in 2011 was $80,000. Little financial assistance, other than student loans, is available to PA students. Eighty-five percent of PA students report owing some PA education debt amount, with 23% owing at least $100,000...
March 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28220991/molten-ag2so4-based-ion-exchange-preparation-of-a-novel-ag0-5la0-5tio3-material-for-photocatalytic-o2-evolution
#16
Shichao Zong, Cheng Cheng, Jinwen Shi, Zhenxiong Huang, Yuchao Hu, Honghui Yang, Liejin Guo
A novel material, Ag0.5La0.5TiO3, with ABO3 perovskite structure was synthesized by a newly developed ion-exchange method. Molten Ag2SO4 instead of traditional molten AgNO3 was used as Ag+ source in view of high decomposition temperature (1052 oC) of Ag2SO4, thereby guaranteeing the complete substitution of Ag+ for Na+ in Na0.5La0.5TiO3 with stable ABO3 perovskite structure, in which it is difficult to exchange Na+ with Ag+, to obtain Ag0.5La0.5TiO3 at a high ion-exchange temperature (700 oC) above the melting temperature (652 oC) of Ag2SO4...
February 21, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28220961/carbon-based-perovskite-solar-cells-without-hole-transport-materials-the-front-runner-to-the-market
#17
REVIEW
Haining Chen, Shihe Yang
Organometal trihalide perovskite solar cells (PSCs) have garnered recent interest in the scientific community. In the past few years, they have achieved power conversion efficiencies comparable to traditional commercial solar cells (e.g., crystalline Si, CuInGaSe and CdTe) due to their low-cost of production via solution-processed fabrication techniques. However, the stability of PSCs must be addressed before their commercialization is viable. Among various kinds of PSCs, carbon-based PSCs without hole transport materials (C-PSCs) seem to be the most promising for addressing the stability issue because carbon materials are stable, inert to ion migration (which originates from perovskite and metal electrodes), and inherently water-resistant...
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28220850/comparing-the-survival-rate-of-juvenile-chinook-salmon-migrating-through-hydropower-systems-using-injectable-and-surgical-acoustic-transmitters
#18
Z D Deng, J J Martinez, H Li, R A Harnish, C M Woodley, J A Hughes, X Li, T Fu, J Lu, G A McMichael, M A Weiland, M B Eppard, J R Skalski, R L Townsend
Acoustic telemetry is one of the primary technologies for studying the behavior and survival of fishes throughout the world. The size and performance of the transmitter are key limiting factors. The newly developed injectable transmitter is the first acoustic transmitter that can be implanted via injection instead of surgery. A two-part field study was conducted to evaluate the performance of the injectable transmitter and its effect on the survival of implanted fish. The injectable transmitter performed well and similarly to the proceeding generation of commercially-available JSATS transmitters tested concurrently...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220848/elevated-expression-of-placental-growth-factor-is-associated-with-airway-wall-vascular-remodelling-and-thickening-in-smokers-with-asthma
#19
Dong Wu, Tianwen Lai, Yalian Yuan, Min Chen, Jun Xia, Wen Li, Guihai Pan, Binfan Yuan, Quanchao Lv, Yanyu Li, Dongmin Li, Bin Wu
The increased expression of placental growth factor (PlGF) in chronic obstructive pulmonary disease and allergy-related asthma suggests its role in the pathogenesis of these diseases. In asthmatic smokers, airway remodelling is accompanied by an accelerated decline in lung function. However, whether PlGF contributes to the persistent airflow obstruction and vascular remodelling typically seen in asthmatic smokers is unknown. In this study we measured lung function, airway-wall thickening, and PlGF levels in serum and induced sputum in 74 asthmatic and 42 healthy smokers and never-smokers...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220837/a-novel-role-of-the-organizer-gene-goosecoid-as-an-inhibitor-of-wnt-pcp-mediated-convergent-extension-in-xenopus-and-mouse
#20
Bärbel Ulmer, Melanie Tingler, Sabrina Kurz, Markus Maerker, Philipp Andre, Dina Mönch, Marina Campione, Kirsten Deißler, Mark Lewandoski, Thomas Thumberger, Axel Schweickert, Abraham Fainsod, Herbert Steinbeißer, Martin Blum
Goosecoid (Gsc) expression marks the primary embryonic organizer in vertebrates and beyond. While functions have been assigned during later embryogenesis, the role of Gsc in the organizer has remained enigmatic. Using conditional gain-of-function approaches in Xenopus and mouse to maintain Gsc expression in the organizer and along the axial midline, neural tube closure defects (NTDs) arose and dorsal extension was compromised. Both phenotypes represent convergent extension (CE) defects, arising from impaired Wnt/planar cell polarity (PCP) signaling...
February 21, 2017: Scientific Reports
keyword
keyword
2249
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"