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Ming-Shiun Tsai, Ying-Han Wang, Yan-Yun Lai, Hsi-Kai Tsou, Gan-Guang Liou, Jiunn-Liang Ko, Sue-Hong Wang
Acetaminophen (APAP) overdose can induce acute liver injury (ALI) with significant morbidity and mortality. Propacetamol is an APAP prodrug, which is clinically bioequivalent to APAP. Kaempferol, a dietary flavonoid, has antioxidant, anti-inflammatory, and anti-apoptotic effects. In this study, we investigated the protective effect of kaempferol on propacetamol-induced ALI and its underlying mechanism in mice. Kaempferol pretreatment (125 mg/Kg) before propacetamol injection significantly decreased propacetamol-induced serum ALT and AST activities, and DNA fragmentation...
March 21, 2018: Toxicology Letters
D N Luo, F J Li, Y Y Zou
Objective: To determine the therapic effects of rutaecarpine in dextran sodium sulfate (DSS)induced experimental colitis and explore whether the protective role of rutaecarpine is related to the synthesis and release of CGRP. Methods: Fifty female BABL/c strain mice were randomly divided into untreated model control group and DSS-exposed groups.DSS-exposed groups were given administration of 5% DSS for 7 days and respectively treated with vehicle, rutacarpine(30 mg/kg, 100 mg/kg) , prednisone by intragastric administration from day 8 to day 14...
February 13, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Bian Li, Wang Tao, Zhang Shao-Hua, Qu Ze-Rui, Jin Fu-Quan, Li Fan, Jiang Ze-Fei
In clinical practice, one subgroup patients of breast cancer might have developed resistance to multi-anti-HER2 targeted drugs(trastuzumab, lapatinib and/or T-DM1) and can not benefit from the anti-HER2 targeted therapy continuously. We attempt to change the next therapic way for these patients. Two patients with metastatic breast cancer who have failed to multi-anti-HER2 targeted therapy were treated with pembrolizumab (2 mg/Kg, day1) plus albumin-bound paclitaxel (125 mg/m2 , day1,8) every 3 weeks. CT evaluation and HER2 ECD test were performed every 2 cycles...
April 3, 2018: Cancer Biology & Therapy
Chang Guo, Jingfan Ma, Qionghong Zhong, Mengyuan Zhao, Tianxing Hu, Tong Chen, Longxin Qiu, Longping Wen
Alcoholic fatty liver is a threat to human health. It has been long known that abstinence from alcohol is the most effective therapy, other effective therapies are not available for the treatment in humans. Curcumin has a great potential for anti-oxidation and anti-inflammation, but the effect on metabolic reconstruction remains little known. Here we performed metabolomic analysis by gas chromatography/mass spectrometry and explored ethanol pathogenic insight as well as curcumin action pattern. We identified seventy-one metabolites in mouse liver...
August 1, 2017: Toxicology and Applied Pharmacology
Jessica E Morgan, Hadeel Hassan, Julia V Cockle, Christopher Lethaby, Beki James, Robert S Phillips
PURPOSE: The incidence of invasive fungal disease (IFD) is rising, but its treatment in paediatric haematology and oncology patients is not yet standardised. This review aimed to critically appraise and analyse the clinical practice guidelines (CPGs) that are available for paediatric IFD. METHODS: Electronic searches of MEDLINE, MEDLINE in-Process & Other non-Indexed Citations, the Guidelines International Network (GIN), and Google were performed and combined fungal disease (Fung* OR antifung*OR Candida* OR Aspergill*) with prophylaxis or treatment (prophyl* OR therap* OR treatment)...
January 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Richard L Rauck, Kyung-Soo Jason Hong, James North
Chronic pain patients relying on chronic opioid therapy are often challenged with opioid-induced constipation (OIC), a difficult condition to treat that has a significant psychosocial impact on those who are affected (Bruner et al., J Pain Res, 8, 2015, 289). Unlike other side effects of opioids, OIC does not resolve over time during chronic opioid use, and treatments used for functional constipation often fail to provide adequate symptom relief (Nelson and Camilleri, Therap Adv Gastroenterol, 8, 2015, 206)...
March 2017: Pain Practice: the Official Journal of World Institute of Pain
Thamara E Osinga, Anouk N A van der Horst-Schrivers, Martijn van Faassen, Michiel N Kerstens, Robin P F Dullaart, Karel Pacak, Thera P Links, Ido P Kema
BACKGROUND: Determination of metanephrine (MN), normetanephrine (NMN), and 3-methoxytyramine (3-MT) in saliva may offer potential diagnostic advantages in diagnosing pheochromocytoma. METHODS: In this preliminary study, we determined metanephrine concentrations in saliva of healthy subjects and the relationship with simultaneously measured plasma metanephrines. We also studied the possible influence of pre-analytical conditions such as a collection device, awakening, posture, and eating on the salivary metanephrine levels...
September 2016: Clinical Biochemistry
Ying Xu, Ning-Yu Wang, Xue-Jiao Song, Qian Lei, Ting-Hong Ye, Xin-Yu You, Wei-Qiong Zuo, Yong Xia, Li-Dan Zhang, Luo-Ting Yu
FLT3 inhibitors have been explored as a viable therapy for acute myeloid leukemia (AML). However, the clinical outcomes of these FLT3 inhibitors were underwhelming except AC220. Therefore, the development of novel FLT3 inhibitors with high potency against both FLT3-WT and FLT3-ITD mutants are strongly demanded at the present time. In this study, we designed and synthesized a series of novel N-(5-(tert-butyl)isoxazol-3-yl)-N'-phenylurea derivatives as FLT3 inhibitors. SAR studies focused on the fused rings led to the discovery of a series of compounds with high potency against FLT3-ITD-bearing MV4-11 cells and significantly inhibitory activity toward FLT3...
August 1, 2015: Bioorganic & Medicinal Chemistry
Maurilio Giuseppe Maria Tavormina, Romina Tavormina, Eugenio Nemoianni
Psychosocial rehabilitation, and choral singing in particular, allow the recovery of lost or compromised ability of patients with mental illness and they facilitate the reintegration of the user in his family and into his social context. The choral singing, used as an operational tool for psychosocial rehabilitation, allowed users of the Day Centre of the Unit of Mental Health Torre del Greco ASL NA 3 South to achieve concrete goals of rehabilitation: improvement of self-care and self-esteem, the management of emotions, the growing of their interests, the integration and socialization overcoming the isolation of their mental suffering...
November 2014: Psychiatria Danubina
P Mundre, L Smith, A Rehman, B Rembacken
INTRODUCTION: Although there is a low risk of malignant conversion of duodenal polyps in FAP, EMR is often considered. However, few studies have looked at the safety and efficacy of EMR. We compared the outcome of duodenal EMR's in patients with FAP vs sporadic adenomas. To our knowledge, this is the largest series of duodenal EMRs that is published so far.(1) METHODS: We looked at Clinical records of all patients who underwent endoscopic resections for duodenal adenomas at Leeds in a 10 year period...
June 2014: Gut
Wj Czuber-Dochan, C Norton, S Berliner, F Bredin, M Darvell, A Forbes, M Gay, I Nathan, E Ream, H Terry
INTRODUCTION: Fatigue is one of the top complaints in inflammatory bowel disease (IBD) with 40% of patients in remission and 86% in active condition reporting fatigue.(1) However patients report that their complaints of fatigue are often not addressed in clinical consultations.(2) This study aimed to gain an understanding of healthcare practitioners' (HCPs) perception of IBD fatigue as experienced by people with IBD. METHODS: Descriptive phenomenology with purposive sampling was used to identify a range of professionals (gastroenterologists, IBD nurses, general practitioners, dietitians, psychologists and pharmacists)...
June 2014: Gut
L H S Lim
A new genus of the Monogenea, Teraplectanum n. g., is proposed for two new species of diplectanids found on the gills of Terapon theraps Cuvier collected off Carey Island, Peninsular Malaysia. The genus is based on a unique arrangement of the male reproductive system. In the new species spermatozoa stored in the seminal vesicle and secretions stored in the prostatic reservoir are transferred into, and mixed to form semen within, a special sclerotized auxiliary piece (SAP), and not within the copulatory tube as occurs in the majority of monogeneans...
May 2015: Journal of Helminthology
Muhammad Talha Khan, Rose Amy Franco
Complex sleep apnea is the term used to describe a form of sleep disordered breathing in which repeated central apneas (>5/hour) persist or emerge when obstructive events are extinguished with positive airway pressure (PAP) and for which there is not a clear cause for the central apneas such as narcotics or systolic heart failure. The driving forces in the pathophysiology are felt to be ventilator instability associated oscillation in PaCO2 arterial partial pressure of Carbon Dioxide, continuous cositive airway pressure (CPAP) related increased CO2 carbon dioxide elimination, and activation of airway and pulmonary stretch receptors triggering these central apneas...
2014: Sleep Disorders
Adrián Tóth, Gabriella Aradi, György Várallyay, Zsuzsanna Arányi, Dániel Bereczki, Ildikó Vastagh
Wernicke's encephalopathy is an acute, potentially life-threatening, neurological syndrome resulting from thiamine deficiency. The disorder is still greatly underdiagnosed and, without prompt treatment, the condition can lead to the chronic form of the disease, Korsakoff's syndrome or even death. In developed countries Wernicke's encephalopathy has been associated with alcoholism, but in recent years there has been an increasing number of non-alcoholic cases. Authors report the case of a 23-year-old woman who developed oculomotor dysfunction, encephalopathy and ataxia as a result of an extreme diet and use of diet pills...
March 23, 2014: Orvosi Hetilap
E Ricciardi, P Maniglio, R Marziani, A Frega, M Moscarini
Most of the cases showing good prognosis in literature are probably intermediate tumors between benign and malignant of undetermined malignant potential (UMP) and other tumors with intermediate features which are currently not considered among sarcomas. Misdiagnosis of a malignant lesion as a benign one has a tragic outcome for the patient. Best therapic choice for sarcomas remains surgery, while chemotherapy (CTX) and radiation therapy (RT) could be used in adjuvant settings. A major effort should be played in the understanding of biological features and behavior of the disease to address a better clinical practice...
2013: European Journal of Gynaecological Oncology
Gillian King, Barbara E Gibson, Bhavnita Mistry, Madhu Pinto, Freda Goh, Gail Teachman, Laura Thompson
PURPOSE: The aim was to examine the leisure activity setting experiences of two groups of youth with severe disabilities - those with complex continuing care (CCC) needs and those who have little functional speech and communicate using augmentative and alternative communication (AAC). METHOD: Twelve youth took part in a mixed methods study, in which their experiences were ascertained using qualitative methods (observations, photo elicitation and interviews) and the measure of Self-Reported Experiences of Activity Settings (SEAS)...
2014: Disability and Rehabilitation
Hui Xiao, Jian Qin, You-Xing Zhang
No abstract text is available yet for this article.
August 2013: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Yu-Zhang Liu, Shi-Min Zhang, Fu-Hui Dong, Wei Zhou, Xing Li, Lu-Tang Zhang, Yong-Dong Zhang, Zuo-Xu Li, Guan-Nan Wu, Zhao-Jie Zhang, Ming Ma
OBJECTIVE: To explore the reason,diagnose outline,therapeutic tool of the incisions deep infections at early stage after lumber internal fixation. METHODS: From January 2001 to December 2011, 10 patients with incisions deep infections at the early stage after the posterior lumber internal fixation were treated with intervertebral space lavaging. There were 1 male and 9 females with an average age of 63 years, and an average infection started at the 6th day after operation...
October 2012: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
J-J Cabaud, L Bourguignat
Transport products blood and samples of human blood is one of the keys of transfusional safety forcing all actors to update their know how and to comply with rigorous rules and high level capabilities requirements. This must lead blood transfusion institutes and medical and biologic laboratories to implement specific process insuring safe transport, preservation and avaibility of the items in accordance with patients' therapic needs. Training and regular valuation of involved actors make necessary to update tools and training methods...
November 2012: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
María Teresa Rosanova, Daniel Stamboulian, Roberto Lede
Topical agents are widely used in the care of burn patients; however the efficacy to prevent local infections and/or sepsis has not been clearly established in studies with a high level of evidence. This systematic review was conducted to assess the comparative efficacy among different topical agents. Material and Methods. The literature search was performed using the Medline database. Key MESH terms were: (burn* or scald*) AND (antibacterial or antibiotic*) AND (topic*) AND (therap* or prophylax*). Only randomized or quasi-randomized clinical trials, with a primary endpoint of local infection and/or sepsis were included...
August 2012: Archivos Argentinos de Pediatría
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