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Ischaemic heart disease

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https://www.readbyqxmd.com/read/29680771/exercise-induced-left-bundle-branch-block-in-isotopic-exercise-test-findings-and-prognostic-value
#1
M V Gomez, B C Lorente Castro, P Jané, L García-Zoghby, A Martínez-Lorca, J A Pérez
INTRODUCTION: Exercise-induced left bundle branch block (EI-LBBB) is a rare circumstance of unknown significance. The purpose of this paper is to describe the scintigraphic features and the prognostic value of this finding. MATERIAL AND METHODS: We reviewed the features of 1,885 patients who had visited our department to undergo GATED-SPECT ergometry to diagnose ischaemic heart disease. Seven patients showed EI-LBBB throughout the exercise testing. Coronary angiography was performed in 4 of them...
April 18, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29678257/-functional-status-as-an-independent-risk-factor-in-elderly-patients-admitted-to-an-intensive-care-unit
#2
Federico Gordo, Cristina Castro, Inés Torrejón, Sonia Bartolomé, Francisco Coca, Ana Abella
OBJECTIVE: To assess the association of previous functional status in elderly patients admitted to the ICU, estimated by the Barthel and Short Form-Late Life Function and Disability instrument scales, and the relationship with prognosis and functional capacity at hospital discharge. MATERIAL AND METHODS: Observational prospective study of ICU-admitted patients older than 74 years, with a length of stay greater than 48hours. Demographic data, social background, comorbidities, disability questionnaire (Barthel, Short Form-Late Life Function and Disability instrument), main diagnosis and severity (SAPS 3) on ICU admission were recorded...
April 17, 2018: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29674367/trends-in-diagnosis-specific-work-disability-before-and-after-ischaemic-heart-disease-a-nationwide-population-based-cohort-study-in-sweden
#3
Jenni Ervasti, Marianna Virtanen, Tea Lallukka, Emilie Friberg, Ellenor Mittendorfer-Rutz, Erik Lundström, Kristina Alexanderson
OBJECTIVES: We examined trends of diagnosis-specific work disability before and after ischaemic heart disease (IHD). DESIGN: Participants were followed 4 years before and 4 years after an IHD event for diagnosis-specific work disability (sickness absence and disability pension). SETTING AND PARTICIPANTS: A Swedish population-based cohort study using register data on all individuals aged 25-60 years, living in Sweden, and who suffered their first IHD event in 2006-2008 (n=23 971) was conducted...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29667349/asb1-differential-methylation-in-ischaemic-cardiomyopathy-relationship-with-left-ventricular-performance-in-end-stage-heart-failure-patients
#4
Ana Ortega, Estefanía Tarazón, Carolina Gil-Cayuela, Luis Martínez-Dolz, Francisca Lago, José Ramón González-Juanatey, Juan Sandoval, Manuel Portolés, Esther Roselló-Lletí, Miguel Rivera
AIMS: Ischaemic cardiomyopathy (ICM) leads to impaired contraction and ventricular dysfunction, causing high rates of morbidity and mortality. Epigenomics allows the identification of epigenetic signatures in human diseases. We analyse the differential epigenetic patterns of the ASB gene family in ICM patients and relate these alterations to their haemodynamic and functional status. METHODS AND RESULTS: Epigenomic analysis was carried out using 16 left ventricular (LV) tissue samples, eight from ICM patients undergoing heart transplantation and eight from control (CNT) subjects without cardiac disease...
April 17, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29666943/the-gtn-patch-a-simple-and-effective-new-approach-to-cardioprotection
#5
Derek M Yellon, Zhenhe He, Rayomand Khambata, Amrita Ahluwalia, Sean M Davidson
There remains a significant un-met need to reduce the extent of myocardial injury caused by ischaemia and reperfusion injury in patients experiencing an ST-elevation MI. Although nitric oxide is central to many cardioprotective strategies currently undergoing investigation, cardioprotection from the delivery of nitrates/nitrites has been inconsistently observed. The route of administration appears to be a critical variable. The glyceryl trinitrate (GTN) patch is commonly used as a simple and practical means of delivering nitric oxide to patients with ischaemic heart disease, but whether acute cardioprotection can be achieved by application of a GTN patch has not been investigated before...
April 17, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29666676/ranolazine-a-true-pluripotent-cardiovascular-drug-or-jack-of-all-trades-master-of-none
#6
REVIEW
Alice Mezincescu, V J Karthikeyan, Sunil K Nadar
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Although the majority of patients with CVD are treated with interventional procedures, a substantial number require medical therapy in terms of both prognosis and symptomatic relief. However, commonly used agents such as β-blockers and calcium channel blockers reduce blood pressure in patients whose resting pressures are often already low. Ranolazine is a promising agent that does not have significant effects on blood pressure or heart rate...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29666179/increasing-trends-in-hospital-care-burden-of-atrial-fibrillation-in-korea-2006-through-2015
#7
Daehoon Kim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip
OBJECTIVE: Temporal changes in the healthcare burden of atrial fibrillation (AF) are less well known in rapidly ageing Asian countries. We examined trends in hospitalisations, costs, treatment patterns and outcomes related to AF in Korea. METHODS: Using the National Health Insurance Service (NHIS) database involving the entire adult Korean population (n=41 701 269 in 2015), we analysed a nationwide AF cohort representing 931 138 patients with AF. We studied all hospitalisations due to AF from 2006 to 2015...
April 17, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29664033/ischaemic-heart-disease-mortality-in-serbia-1991-2013-a-joinpoint-analysis
#8
Milena Ilic, Irena Ilic
Background & objectives: Ischaemic heart disease (IHD) has been one of the leading causes of mortality in the world. In many European countries the mortality rates due to IHD have been rising rapidly. This study was aimed to assess the IHD mortality trend in Serbia. Methods: A population-based cross-sectional study analyzing IHD mortality in Serbia in the period 1991-2013 was carried out based on official data. The age-standardized rates (ASRs, per 100,000) were calculated using the direct method, according to the European standard population...
December 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29661934/nut-consumption-and-incidence-of-seven-cardiovascular-diseases
#9
Susanna C Larsson, Nikola Drca, Martin Björck, Magnus Bäck, Alicja Wolk
BACKGROUND: Nut consumption has been found to be inversely associated with cardiovascular disease mortality, but the association between nut consumption and incidence of specific cardiovascular diseases is unclear. We examined the association between nut consumption and incidence of seven cardiovascular diseases. METHODS: This prospective study included 61 364 Swedish adults who had completed a Food Frequency Questionnaire and were followed up for 17 years through linkage with the Swedish National Patient and Death Registers...
April 16, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29660843/mortality-after-a-cerebrovascular-event-in-age-related-macular-degeneration-patients-treated-with-bevacizumab-ocular-injections
#10
Joel Hanhart, Doron S Comaneshter, Shlomo Vinker
PURPOSE: To analyse the mortality associated with intravitreal injections of bevacizumab for age-related macular degeneration (AMD) in patients previously diagnosed with stroke or transient ischaemic attack (TIA). METHODS: We reviewed bevacizumab-treated AMD patients with a diagnosis of stroke or TIA prior to their first bevacizumab injection (n = 948). Those patients, naïve to any anti-vascular endothelial growth factor (anti-VEGF) at the time of stroke/TIA, were then compared to age- and gender-matched patients who had a stroke/TIA at the same time and had never been exposed to anti-VEGF...
April 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29660263/characteristics-and-long-term-prognosis-of-patients-with-heart-failure-and-mid-range-ejection-fraction-compared-with-reduced-and-preserved-ejection-fraction-a-systematic-review-and-meta-analysis
#11
Josephine Lauritsen, Finn Gustafsson, Jawdat Abdulla
AIMS: This study aimed to assess by a meta-analysis the clinical characteristics, all-cause and cardiovascular mortality, and hospitalization of patients with heart failure (HF) with mid-range ejection fraction (HFmrEF) compared with HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). METHODS AND RESULTS: Data from 12 eligible observational studies including 109 257 patients were pooled. HFmrEF patients were significantly different and occupied a mid-position between HFrEF and HFpEF: mean age 73...
April 16, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29659130/microrna-21-drives-the-switch-to-a-synthetic-phenotype-in-human-saphenous-vein-smooth-muscle-cells
#12
Aliah R Alshanwani, Kirsten Riches-Suman, David J O'Regan, Ian C Wood, Neil A Turner, Karen E Porter
Cardiovascular disease is a leading cause of morbidity and mortality. Smooth muscle cells (SMC) comprising the vascular wall can switch phenotypes from contractile to synthetic, which can promote the development of aberrant remodelling and intimal hyperplasia (IH). MicroRNA-21 (miR-21) is a short, non-coding RNA that has been implicated in cardiovascular diseases including proliferative vascular disease and ischaemic heart disease. However, its involvement in the complex development of atherosclerosis has yet to be ascertained...
April 16, 2018: IUBMB Life
https://www.readbyqxmd.com/read/29627159/investing-in-non-communicable-diseases-an-estimation-of-the-return-on-investment-for-prevention-and-treatment-services
#13
REVIEW
Melanie Y Bertram, Kim Sweeny, Jeremy A Lauer, Daniel Chisholm, Peter Sheehan, Bruce Rasmussen, Senendra Raj Upreti, Lonim Prasai Dixit, Kenneth George, Samuel Deane
The global burden of non-communicable diseases (NCDs) is growing, and there is an urgent need to estimate the costs and benefits of an investment strategy to prevent and control NCDs. Results from an investment-case analysis can provide important new evidence to inform decision making by governments and donors. We propose a methodology for calculating the economic benefits of investing in NCDs during the Sustainable Development Goals (SDGs) era, and we applied this methodology to cardiovascular disease prevention in 20 countries with the highest NCD burden...
April 5, 2018: Lancet
https://www.readbyqxmd.com/read/29625727/effectiveness-of-screening-postmenopausal-women-for-cardiovascular-diseases-a-population-based-prospective-parallel-cohort-study
#14
Marie Dahl, Rikke Søgaard, Lars Frost, Annette Høgh, Jes Lindholt
OBJECTIVES: To investigate the effectiveness of systematic screening for multifaceted cardiovascular disease (CVD) in postmenopausal women on all cause mortality and, secondarily, on CVD morbidity. Effectiveness was also evaluated across age strata. METHODS: This was a population based, prospective, parallel cohort study. In total, 107,491 women born in 1936-1951 living in the Central Denmark region were identified in the Danish Civil Registration System. From this population, all women born in 1936, 1941, 1946, and 1951 (n = 1984) living in the Viborg municipality were invited to attend screening...
April 3, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29622568/impact-of-age-and-comorbidity-on-risk-stratification-in-idiopathic-pulmonary-arterial-hypertension
#15
Clara Hjalmarsson, Göran Rådegran, David Kylhammar, Bengt Rundqvist, Jonas Multing, Magnus D Nisell, Barbro Kjellström
Background. Recent reports from worldwide pulmonary hypertension registries show a new demographic picture of the idiopathic pulmonary arterial hypertension (IPAH) population, with an increasing prevalence among the elderly. Aim To investigate the effect of age and comorbidity on risk stratification and outcome of patients with incident IPAH. Methods and results The study population (n=264) was categorized in four age groups; 18-45, 46-64, 65-74, and ≥75 years. Individual risk profile was determined according to a risk assessment instrument, based on the ESC/ERS guidelines...
April 5, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29622520/coronary-microcirculation-in-acute-myocardial-ischaemia-from-non-invasive-to-invasive-absolute-flow-assessment
#16
REVIEW
Julien Adjedj, Fabien Picard, Guillaume Durand-Viel, Anne Sigal-Cinqualbre, Doumit Daou, Benoit Diebold, Olivier Varenne
Although substantial progress has been made in recent decades in reducing mortality and performing optimal revascularization in patients with myocardial infarction, ischaemic heart disease, including acute coronary syndrome, remains the leading cause of mortality worldwide. One of the remaining challenges is to better detect, prevent and treat extended myocardial damage despite angiographically optimal revascularization. Several indices are available in clinical practice to evaluate myocardial damage, infarct size and potential myocardial recovery...
April 2, 2018: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29621274/phenotype-and-biochemical-heterogeneity-in-late-onset-fabry-disease-defined-by-n215s-mutation
#17
L Lavalle, A S Thomas, B Beaton, H Ebrahim, M Reed, U Ramaswami, P Elliott, A B Mehta, D A Hughes
BACKGROUND: Fabry disease (FD) results from X-linked inheritance of a mutation in the GLA gene, encoding for alpha galactosidase A, and is characterized by heterogeneous clinical manifestations. Two phenotypes have been described "Classic" and "late onset" which cannot be predicted exclusively by genotype. The latter has been considered an attenuated form of the disease often affecting a single organ system commonly the heart. Recent studies have demonstrated that cardiac outcomes are similar in patients with classic and late onset mutations...
2018: PloS One
https://www.readbyqxmd.com/read/29621272/mortality-in-a-cohort-of-remote-living-aboriginal-australians-and-associated-factors
#18
Zoë Hyde, Kate Smith, Leon Flicker, David Atkinson, Osvaldo P Almeida, Nicola T Lautenschlager, Anna Dwyer, Dina LoGiudice
OBJECTIVES: We aimed to describe mortality in a cohort of remote-living Aboriginal Australians using electronic record linkage. METHODS: Between 2004 and 2006, 363 Aboriginal people living in remote Western Australia (WA) completed a questionnaire assessing medical history and behavioural risk factors. We obtained mortality records for the cohort from the WA Data Linkage System and compared them to data for the general population. We used Cox proportional hazards regression to identify predictors of mortality over a 9-year follow-up period...
2018: PloS One
https://www.readbyqxmd.com/read/29619987/comorbidities-of-bullous-pemphigoid-in-a-finnish-cohort
#19
Anna Pankakoski, Harri Sintonen, Annamari Ranki, Nicolas Kluger
The incidence of bullous pemphigoid (BP) is increasing in Finland. To investigate the clinical presentation, comorbidities, and medications in a cohort of Finnish patients with confirmed BP managed in a university hospital setting. An observational retrospective study of all consecutive patients diagnosed with BP in 2012-2013 at the Department of dermatology, HUCH. The prevalence of the most common comorbidities was compared to that in a sample population aged over 30 years. Seventy patients were included (mean age: 77 years at diagnosis)...
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29602853/association-between-refill-adherence-to-lipid-lowering-medications-and-the-risk-of-cardiovascular-disease-and-mortality-in-swedish-patients-with-type-2-diabetes-mellitus-a-nationwide-cohort-study
#20
Sofia Axia Karlsson, Christel Hero, Ann-Marie Svensson, Stefan Franzén, Mervete Miftaraj, Soffia Gudbjörnsdottir, Katarina Eeg-Olofsson, Björn Eliasson, Karolina Andersson Sundell
OBJECTIVES: To analyse the association between refill adherence to lipid-lowering medications, and the risk of cardiovascular disease (CVD) and mortality in patients with type 2 diabetes mellitus. DESIGN: Cohort study. SETTING: National population-based cohort of Swedish patients with type 2 diabetes mellitus. PARTICIPANTS: 86 568 patients aged ≥18 years, registered with type 2 diabetes mellitus in the Swedish National Diabetes Register, who filled at least one prescription for lipid-lowering medication use during 2007-2010, 87% for primary prevention...
March 30, 2018: BMJ Open
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