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Ischaemic heart disease

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https://www.readbyqxmd.com/read/29921218/a-comparison-of-lkb1-ampk-mtor-metabolic-axis-response-to-global-ischaemia-in-brain-heart-liver-and-kidney-in-a-rat-model-of-cardiac-arrest
#1
Shohreh Majd, John H T Power, Timothy K Chataway, Hugh J M Grantham
BACKGROUND: Cellular energy failure in high metabolic rate organs is one of the underlying causes for many disorders such as neurodegenerative diseases, cardiomyopathies, liver and renal failures. In the past decade, numerous studies have discovered the cellular axis of LKB1/AMPK/mTOR as an essential modulator of cell homeostasis in response to energy stress. Through regulating adaptive mechanisms, this axis adjusts the energy availability to its demand by a systematized control on metabolism...
June 19, 2018: BMC Cell Biology
https://www.readbyqxmd.com/read/29917065/contribution-of-chronic-conditions-to-gender-disparities-in-health-expectancies-in-belgium-2001-2004-and-2008
#2
Renata T C Yokota, Willma J Nusselder, Jean-Marie Robine, Jean Tafforeau, Françoise Renard, Patrick Deboosere, Herman Van Oyen
Background: We aimed to investigate the contribution of chronic conditions to gender differences in disability-free life expectancy (DFLE) and life expectancy with disability (LED) in Belgium in 2001, 2004 and 2008. Methods: Data on disability and chronic conditions from participants of the 2001, 2004 and 2008 Health Interview Surveys in Belgium were used to estimate disability prevalence by cause using the attribution method. Disability prevalence was applied to life tables to estimate DFLE and LED using the Sullivan method...
June 15, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29916560/sex-drugs-and-heart-failure-a-sex-sensitive-review-of-the-evidence-base-behind-current-heart-failure-clinical-guidelines
#3
REVIEW
Anna Levinsson, Marie-Pierre Dubé, Jean-Claude Tardif, Simon de Denus
Heart failure (HF) is a complex disease, almost as common in women as in men. Nonetheless, HF clinical presentation, prognosis, and aetiology vary by sex. This review summarizes the current state of sex-sensitive issues related to HF drugs included in treatment guidelines and suggests future directions for improved care. Heart failure presentation differs between female and male patients: females more often show with hypertensive aetiology and the preserved ejection fraction phenotype, while men more often show ischaemic aetiology and the reduced ejection fraction phenotype...
June 19, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29912803/association-of-fatty-liver-index-with-the-risk-of-incident-cardiovascular-disease-and-acute-myocardial-infarction
#4
Olubunmi O Olubamwo, Jyrki K Virtanen, Ari Voutilainen, Jussi Kauhanen, Jussi Pihlajamäki, Tomi-Pekka Tuomainen
BACKGROUND: Fatty liver disease (FLD) has been identified as constituting cardiometabolic risk. However, evidence on the association of fatty liver index (FLI) with cardiovascular disease (CVD) is largely cross-sectional, with limited evidence on the predictability of incident CVD, and specifically, acute myocardial infarction (AMI). Therefore, we aimed to investigate the prospective associations between fatty liver as estimated by FLI and incident CVD, and specifically AMI, in the Kuopio Ischaemic Heart Disease Risk Factor Study cohort...
June 16, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29909368/long-weekly-working-hours-and-ischaemic-heart-disease-a-follow-up-study-among-145-861-randomly-selected-workers-in-denmark
#5
Harald Hannerz, Ann Dyreborg Larsen, Anne Helene Garde
OBJECTIVES: The aim of the present study was to test if incidences of ischaemic heart disease (IHD) and usage of antihypertensive drugs are independent of weekly working hours (WWH) among full-time employees in Denmark. DESIGN AND PARTICIPANTS: Data on WWH from participants of the Danish labour force surveys, 1999-2013, were linked on an individual level to national registers with data on socioeconomic status (SES), industry, emigrations, redeemed prescriptions, hospital contacts and deaths...
June 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29905788/extended-use-of-the-wearable-cardioverter-defibrillator-in-patients-at-risk-for-sudden-cardiac-death
#6
Valentina Kutyifa, Katherine Vermilye, Usama A Daimee, Scott McNitt, Helmut Klein, Arthur J Moss
Aims: Data on outcomes in patients using the wearable cardioverter-defibrillator (WCD) > 90 days are limited. We aimed to analyse the clinical course of patients with WCD use ≤90 days vs. WCD use >90 days. Methods and results: We assessed arrhythmia events during WCD use, and ejection fraction (EF) improvement/implantable cardioverter-defibrillator (ICD) implantation at the end of WCD use in patients with WCD use ≤90 days vs. WCD use >90 days enrolled in the WEARIT-II registry, further assessed by disease aetiology (ischaemic vs...
June 14, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29903685/periodontal-disease-systemic-inflammation-and-the-risk-of-cardiovascular-disease
#7
REVIEW
Edgar Francisco Carrizales-Sepúlveda, Alejandro Ordaz-Farías, Raymundo Vera-Pineda, Ramiro Flores-Ramírez
Periodontal and cardiovascular disease are both major health issues. Poor oral health has long been associated with the development of systemic diseases, with the typical example being the risk of endocarditis posterior to dental procedures. Through the years, the association of periodontal disease with other non-infectious systemic diseases has been brought to attention. One of the most interesting associations is the one that exists with the development of cardiovascular disease. Many studies, including systematic reviews and meta-analyses, suggest an important association between periodontal disease and ischaemic heart disease, cerebrovascular disease, heart failure, atrial fibrillation and peripheral artery disease...
June 2, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29903684/environment-cancer-and-inequalities-the-urgent-need-for-prevention
#8
REVIEW
Paolo Vineis, Daniela Fecht
The proportion of total deaths attributable to environmental factors is estimated to be 23% of global deaths and 22% of global disability-adjusted life years (DALYs) according to one review. These estimates encompass all environmental agents including infectious agents but excluding behavioural factors. The authors of the review also estimated that 16% (95% CI: 7-41%) of cancer deaths are attributable to environmental risk factors (and 36% [95% CI: 17-52%] for lung cancer). In this article, we focus on the reasons why epidemiology is often unable to account for the whole burden of environmental carcinogens...
June 11, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29901735/contribution-of-chronic-conditions-to-smoking-differences-in-life-expectancy-with-and-without-disability-in-belgium
#9
Renata T C Yokota, Willma J Nusselder, Jean-Marie Robine, Jean Tafforeau, Rana Charafeddine, Lydia Gisle, Patrick Deboosere, Herman Van Oyen
Background: Smoking is the leading cause of premature mortality and morbidity. This study aimed at assessing the impact of smoking on life expectancy (LE) and LE with (LED) and without disability (DFLE). We further estimated the contribution of disability and mortality and their causes to differences in LED and DFLE by smoking. Methods: Data on disability, chronic conditions, and smoking from 17 148 participants of the 1997, 2001, 2004 Belgian Health Interview Surveys were used to estimate causes of disability using the attribution method...
June 12, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29900411/the-effect-of-different-combinations-of-vascular-dependency-and-cognitive-endpoints-on-the-sample-size-required-to-detect-a-treatment-effect-in-trials-of-treatments-to-improve-outcome-after-lacunar-and-non-lacunar-ischaemic-stroke
#10
Stephen Dj Makin, Fergus N Doubal, Terence J Quinn, Philip Mw Bath, Martin S Dennis, Joanna M Wardlaw
Background: Endpoints that are commonly used in trials of moderate/severe stroke may be less frequent in patients with minor, non-disabling stroke thus inflating sample sizes. We tested whether trial efficiency might be improved with composite endpoints. Methods: We prospectively recruited patients with lacunar and minor non-lacunar ischaemic stroke (NIHSS ≤ 7) and assessed recurrent vascular events (stroke, transient ischaemic attack (TIA), ischemic heart disease (IHD)), modified Rankin Score (mRS) and cognitive testing with the Addenbrooke's Cognitive Examination (ACE-R) one year post-stroke...
March 2018: European stroke journal
https://www.readbyqxmd.com/read/29895484/coping-and-cardiac-troponin-t-a-risk-for-hypertension-and-sub-clinical-ecg-left-ventricular-hypertrophy-the-sabpa-study
#11
Catharina Elizabeth Myburgh, Leoné Malan, Annemarie Wentzel, Jacobus De Wet Scheepers, Nicolaas Theodor Malan
BACKGROUND: Defensive coping (DefS) was associated with cardiovascular disease (CVD) susceptibility in Blacks. Whether coping strategies will associate with sub-clinical left ventricular hypertrophy (electrocardiographic-left ventricular hypertrophy [ECG-LVH] or Cornell product), cardiomyocyte injury and blood pressure (BP), is unclear. Therefore, we assessed relationships between ECG-LVH, cardiac troponin T (cTnT) and 24-hour BP in bi-ethnic groups when habitually utilising a certain coping style, and these groups when having a stress-related cTnT cut-point of 4...
May 31, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29878156/management-of-patients-with-ventricular-arrhythmias-and-prevention-of-sudden-cardiac-death-translating-guidelines-into-practice-results-of-the-european-heart-rhythm-association-survey
#12
Kristina H Haugaa, Gheorghe-Andrei Dan, Konstantinos Iliodromitis, Radoslaw Lenarczyk, Germanas Marinskis, Joaquin Osca, Daniel Scherr, Nikolaos Dagres
Prevention of sudden cardiac death (SCD) remains a partly unsolved task in cardiology. The European Society of Cardiology (ESC) guidelines on management of patients with ventricular arrhythmias and prevention of SCD published in 2015 considered the new insights of the natural history of diseases predisposing to SCD. The guidelines improved strategies for management of patients at risk of SCD and included both drug and device therapies. The intention of this survey was to evaluate the extent of the disparities between daily clinical practice and the 2015 SCD ESC guidelines among electrophysiology centres in Europe...
June 5, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29875139/characteristics-and-outcomes-of-adults-with-chronic-obstructive-pulmonary-disease-and-atrial-fibrillation
#13
Michael T Durheim, DaJuanicia N Holmes, Rosalia G Blanco, Larry A Allen, Paul S Chan, James V Freeman, Gregg C Fonarow, Alan S Go, Elaine M Hylek, Kenneth W Mahaffey, Sean D Pokorney, James A Reiffel, Daniel E Singer, Eric D Peterson, Jonathan P Piccini
OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is associated with the development of atrial fibrillation (AF), and may complicate treatment of AF. We examined the association between COPD and symptoms, quality of life (QoL), treatment and outcomes among patients with AF. METHODS: We compared patients with and without a diagnosis of COPD in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation, a prospective registry that enrolled outpatients with AF not secondary to reversible causes, from both academic and community settings...
June 6, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29874661/treatment-of-angina-where-are-we
#14
Cristina Balla, Rita Pavasini, Roberto Ferrari
Ischaemic heart disease is a major cause of death and disability worldwide, while angina represents its most common symptom. It is estimated that approximately 9 million patients in the USA suffer from angina and its treatment is challenging, thus the strategy to improve the management of chronic stable angina is a priority. Angina might be the result of different pathologies, ranging from the "classical" obstruction of a large coronary artery to alteration of the microcirculation or coronary artery spasm...
June 6, 2018: Cardiology
https://www.readbyqxmd.com/read/29872165/therapeutic-approaches-for-cardiac-regeneration-and-repair
#15
REVIEW
Hisayuki Hashimoto, Eric N Olson, Rhonda Bassel-Duby
Ischaemic heart disease is a leading cause of death worldwide. Injury to the heart is followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar tissue. Depletion of cardiomyocytes results in decreased cardiac contraction, which leads to pathological cardiac dilatation, additional cardiomyocyte loss, and mechanical dysfunction, culminating in heart failure. This sequential reaction is defined as cardiac remodelling. Many therapies have focused on preventing the progressive process of cardiac remodelling to heart failure...
June 5, 2018: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29871802/depression-screening-in-cardiac-surgery-patients
#16
Malin Stenman, Ulrik Sartipy
BACKGROUND: Depression is common in patients with ischaemic heart disease and preoperative depression is a risk factor following coronary artery bypass grafting. The American Heart Association recommends depression screening in all patients with heart disease. Our aim was to assess the feasibility and results of a depression screening program in cardiac surgery patients. METHODS: We introduced a depression screening project at the cardiac surgery department at Karolinska University Hospital and included patients between 2013 and 2016...
May 16, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29866727/impact-of-the-pretransplant-dialysis-modality-on-kidney-transplantation-outcomes-a-nationwide-cohort-study
#17
Huan-Tang Lin, Fu-Chao Liu, Jr-Rung Lin, See-Tong Pang, Huang-Ping Yu
OBJECTIVE: Most patients with uraemia must undergo chronic dialysis while awaiting kidney transplantation; however, the role of the pretransplant dialysis modality on the outcomes of kidney transplantation remains obscure. The objective of this study was to clarify the associations between the pretransplant dialysis modality, namely haemodialysis (HD) or peritoneal dialysis (PD), and the development of post-transplant de novo diseases, allograft failure and all-cause mortality for kidney-transplant recipients...
June 4, 2018: BMJ Open
https://www.readbyqxmd.com/read/29858036/abdominal-aortic-aneurysm-prevalence-and-associated-risk-factors-in-a-population-of-patients-hospitalised-in-internal-medicine
#18
S L Belloch García
OBJECTIVES: To determine the prevalence of previously undiagnosed abdominal aortic aneurysm (AAA) in patients hospitalised in a department of internal medicine, as well as the associated risk factors. PATIENTS AND METHODS: An observational, cross-sectional, single-centre, randomised study was conducted on 241 patients hospitalised in Internal Medicine. The patients were older than 50 years, had no previous diagnosis of AAA and underwent clinical ultrasonography...
May 29, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29851627/urban-greenness-and-mortality-in-canada-s-largest-cities-a-national-cohort-study
#19
Dan L Crouse, Lauren Pinault, Adele Balram, Perry Hystad, Paul A Peters, Hong Chen, Aaron van Donkelaar, Randall V Martin, Richard Ménard, Alain Robichaud, Paul J Villeneuve
BACKGROUND: Findings from published studies suggest that exposure to and interactions with green spaces are associated with improved psychological wellbeing and have cognitive, physiological, and social benefits, but few studies have examined their potential effect on the risk of mortality. We therefore undertook a national study in Canada to examine associations between urban greenness and cause-specific mortality. METHODS: We used data from a large cohort study (the 2001 Canadian Census Health and Environment Cohort [2001 CanCHEC]), which consisted of approximately 1·3 million adult (aged ≥19 years), non-immigrant, urban Canadians in 30 cities who responded to the mandatory 2001 Statistics Canada long-form census...
October 2017: Lancet. Planetary Health
https://www.readbyqxmd.com/read/29849578/epidemiology-and-clinical-features-of-adult-patients-with-psoriasis-in-malaysia-10-year-review-from-the-malaysian-psoriasis-registry-2007-2016
#20
Azura Mohd Affandi, Iman Khan, Nooraishah Ngah Saaya
Background: Psoriasis is a chronic inflammatory skin disease affecting 2-3% of the general population. Aim: To evaluate the epidemiology and clinical characteristics of patients with psoriasis who seek treatment in outpatient dermatology clinics throughout hospitals in Malaysia. Materials and Methods: Data were obtained from the Malaysian Psoriasis Registry (MPR). All patients (aged 18 and above) who were notified to the registry from July 2017 to December 2017 were included in this study...
2018: Dermatology Research and Practice
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