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https://www.readbyqxmd.com/read/29682303/heterogeneity-in-hepatitis-c-treatment-prescribing-and-uptake-in-australia-a-geospatial-analysis-of-a-year-of-unrestricted-treatment-access
#1
EDITORIAL
Nick Scott, Samuel W Hainsworth, Rachel Sacks-Davis, Alisa Pedrana, Joseph Doyle, Amanda Wade, Margaret Hellard
Background and aim: Direct-acting antiviral (DAA) treatments became available for all people living with hepatitis C virus (HCV) in Australia in March 2016. We assess variations in treatment rates and prescribing patterns across Australia's 338 Statistical Area 3 (SA3) geographical units. Methods: Geocoded DAA treatment initiation data were analysed for the period 1 March 2016 to 30 June 2017. Regression models tested associations between the population demographics and healthcare service coverage of geographical areas and (a) their treatment rates; and (b) the proportion of prescriptions written by specialists compared to non-specialists...
April 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29675692/uptake-of-and-expenditure-on-direct-acting-antiviral-agents-for-hepatitis-c-treatment-in-australia
#2
Barbara de Graaff, Kwang Chien Yee, Philip Clarke, Andrew Palmer
BACKGROUND: Direct-acting antiviral agents (DAAs) have revolutionised treatment for the hepatitis C virus (HCV). Currently, treatment costs between 20,000 and 80,000 Australian dollars ($A) per patient. The Australian Federal Government provided $A1 billion over 5 years to subsidise these drugs. OBJECTIVE: The aim of this paper was to evaluate the uptake and financial impact of DAA prescribing in Australia. METHODS: We undertook a retrospective analysis of Medicare prescription and expenditure data for March 2016 to August 2017...
April 19, 2018: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29669674/community-views-on-factors-affecting-medicines-resource-allocation-cross-sectional-survey-of-3080-adults-in-australia
#3
Lesley Chim, Glenn Salkeld, Patrick J Kelly, Wendy Lipworth, Dyfrig A Hughes, Martin R Stockler
Objective The aim of the present study was to determine Australian community views on factors that influence the distribution of health spending in relation to medicines. Methods A cross-sectional web-based survey was performed of 3080 adults aged ≥18 years. Participants were asked to rank, in order of importance, 12 criteria according to which medicines funding decisions may be made. Results Of all respondents, 1213 (39.4%) considered disease severity to be the most important prioritisation criterion for funding a new medicine...
April 19, 2018: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29660212/aiming-for-elimination-outcomes-of-a-consultation-pathway-supporting-regional-general-practitioners-to-prescribe-direct-acting-antiviral-therapy-for-hepatitis-c
#4
A J Wade, A McCormack, C Roder, K McDonald, M Davies, N Scott, M Wardrop, E Athan, M E Hellard
To increase access to treatment, the Australian government enabled general practitioners (GPs) to prescribe direct-acting antivirals (DAA) to treat hepatitis C virus (HCV) - in consultation with a specialist if inexperienced in HCV management. This study describes the establishment and outcomes of a remote consultation pathway supporting GPs to treat HCV. Key stakeholders from primary and tertiary healthcare services in the Barwon South Western region developed and implemented an HCV remote consultation pathway...
April 16, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29649285/cost-of-gastroenteritis-in-australia-a-healthcare-perspective
#5
S Fiona Barker, Ella Zomer, Joanne O'Toole, Martha Sinclair, Katherine Gibney, Danny Liew, Karin Leder
BACKGROUND: Acute gastroenteritis illness is a common illness that causes considerable morbidity, but current estimates of the cost to the Australian healthcare system are unknown. OBJECTIVE: To estimate the current healthcare utilisation and direct public healthcare system costs attributable to acute gastroenteritis illness in Australia. METHODS: This is an incidence-based cost-of-illness study focused on quantifying direct health care costs using a bottom-up approach...
2018: PloS One
https://www.readbyqxmd.com/read/29623185/spontaneously-reported-adverse-drug-events-related-to-tapentadol-and-oxycodone-naloxone-in-australia
#6
Carmen Abeyaratne, Samanta Lalic, J Simon Bell, Jenni Ilomäki
Background: The rapid increase in prescribing and use of opioids for noncancer pain has coincided with an increase in opioid-related adverse drug events (ADEs). The objective of our study was to describe ADEs related to tapentadol and oxycodone/naloxone spontaneously reported to the Australian Therapeutic Goods Administration (TGA). Methods: Public case detail reports for tapentadol (September 2013-March 2017) and oxycodone/naloxone (April 2011-March 2017) were sourced from the TGA...
April 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29622502/chronic-pain-medication-management-of-older-populations-key-points-from-a-national-conference-and-innovative-opportunities-for-pharmacy-practice
#7
Julia Fiona-Maree Gilmartin-Thomas, J Simon Bell, Danny Liew, Carolyn A Arnold, Rachelle Buchbinder, Colin Chapman, Flavia Cicuttini, Malcolm Dobbin, Stephen J Gibson, Melita J Giummarra, Jenny Gowan, Benny Katz, Dan L Lubman, Matthew McCrone, Jennifer Pilgrim, Anneliese Synnot, Eleanor van Dyk, Barbara Workman, John McNeil
OBJECTIVE: Inappropriate use of pain medication has serious consequences for older populations. Experts in the field have noted an increase in opioid prescriptions, and opioid-related hospitalisations and deaths among this vulnerable population. In the pursuit of educating pharmacists, physicians, allied healthcare professionals, researchers, academics and the public facing the challenges of chronic pain medication management, 'The Inaugural Monash University School of Public Health and Preventive Medicine (SPHPM) Best Practice in Chronic Pain Medication Management Day Conference' was held in December 2016 at the Alfred Medical Research and Education Precinct (Melbourne, Australia)...
March 19, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29603817/utilisation-of-hepatocellular-carcinoma-screening-in-australians-at-risk-of-hepatitis-b-virus-related-carcinoma-and-prescribed-anti-viral-therapy
#8
Suzanne Sheppard-Law, Iryna Zablotska-Manos, Melissa Kermeen, Susan Holdaway, Alice Lee, Jacob George, Amany Zekry, Lisa Maher
AIMS AND OBJECTIVES: This study aimed to investigate HCC screening utilisation and factors associated with utilisation among patients prescribed HBV anti-viral therapy and at risk of HCC. BACKGROUND: The incidence of hepatocellular carcinoma (HCC) has increased in Australia over the past three decades with chronic hepatitis B virus (HBV) infection a major contributor. HCC surveillance programs aim to detect cancers early enabling curative treatment options, longer survival and longer times to recurrence...
March 31, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29593860/potential-drug-drug-interactions-with-direct-oral-anticoagulants-in-elderly-hospitalized-patients
#9
Heather L Forbes, Thomas M Polasek
Background: To determine the prevalence and nature of potential drug-drug interactions (DDIs) with direct oral anticoagulants (DOACs) in elderly hospitalized patients. Methods: This was a retrospective observational study. Inclusion criteria were: aged over 65 years; taking apixaban, rivaroxaban or dabigatran; and admitted to the Repatriation General Hospital between April 2014 and July 2015. A list of clinically relevant 'perpetrator' drugs was compiled from product information, the Australian Medicines Handbook, the Australian National Prescribing Service resources, and local health network guidelines...
October 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29574073/selective-prescribing-of-statins-and-the-risk-of-mortality-hospitalizations-and-falls-in-aged-care-services
#10
Maarit J Korhonen, Jenni Ilomäki, Janet K Sluggett, M Alan Brookhart, Renuka Visvanathan, Tina Cooper, Leonie Robson, J Simon Bell
BACKGROUND: Compared to randomized controlled trials, nonexperimental studies often report larger survival benefits but higher rates of adverse events for statin use vs nonuse. OBJECTIVE: We compared characteristics of statin users and nonusers living in aged care services and evaluated the relationships between statin use and all-cause mortality, all-cause and fall-related hospitalizations, and number of falls during a 12-month follow-up. METHODS: A prospective cohort study of 383 residents aged ≥65 years was conducted in six Australian aged care services...
March 2, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29573520/bronchiectasis-in-the-kimberley-region-of-western-australia
#11
Justin Barton, Lydia Scott, Graeme Maguire
OBJECTIVE: To review the work-up and inpatient management of non-cystic fibrosis bronchiectasis exacerbations against best practice guidelines in Kimberley, a remote region of Western Australia, with the ultimate goal of improving treatment in the region. DESIGN: Retrospective cohort study and audit of remote adult bronchiectasis hospital admissions between 2011 and 2016. SETTING: Remote hospital inpatients. PARTICIPANTS: Thirty-two patients and 110 hospital admissions were included...
March 24, 2018: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29573074/under-utilisation-of-%C3%AE-blockers-in-patients-with-acute-coronary-syndrome-and-comorbid-chronic-obstructive-pulmonary-disease
#12
L Kratzer, P Noakes, J Baumwol, J P Wrobel
BACKGROUND: β-blockers are an established mainstay of therapy in acute coronary syndrome (ACS). Despite substantial evidence for their safety and efficacy in chronic obstructive pulmonary disease (COPD) patients, their use in this population remains limited internationally, likely due to fears of inducing bronchospasm. In Australia, little is known about the use of β-blockers in COPD patients hospitalised for ACS. AIM: To determine if β-blockers are under-prescribed at discharge for patients with COPD hospitalised for ACS compared to patients without a diagnosis of COPD...
March 23, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29557079/perinatal-outcomes-of-women-diagnosed-with-attention-deficit-hyperactivity-disorder-an-australian-population-based-cohort-study
#13
Alison S Poulton, Bruce Armstrong, Ralph K Nanan
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is common and may require treatment in adulthood. We aimed to investigate the treatment patterns and perinatal outcomes of women with any history of stimulant treatment for ADHD. METHODS: We used health records of the New South Wales (NSW, Australia) population to compare perinatal outcomes of women treated with stimulants (dexamphetamine or methylphenidate) for ADHD from 1982 to 2012 who gave birth between 1994 and 2012, with perinatal outcomes of women with no known ADHD or stimulant treatment (comparison cohort)...
March 19, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29555709/venous-thromboembolism-quality-measures-fail-to-accurately-measure-quality
#14
REVIEW
Brandyn D Lau, Michael B Streiff, Peter J Pronovost, Elliott R Haut
Venous thromboembolism (VTE) is 1 of the most common causes of preventable harm for patients in hospitals. Consequently, the Joint Commission, the Centers for Medicare and Medicaid Services, the Agency for Healthcare Research and Quality, the United Kingdom Care Quality Commission, the Australian Commission on Safety and Quality in Health Care, the Maryland Health Services Cost Review Commission, and the American College of Surgeons have prioritized measuring and reporting VTE outcomes with the goal of reducing the incidence of and preventable harm from VTE...
March 20, 2018: Circulation
https://www.readbyqxmd.com/read/29509558/transferring-patients-from-methadone-to-buprenorphine-the-feasibility-and-evaluation-of-practice-guidelines
#15
Nicholas Lintzeris, Lauren A Monds, Consuelo Rivas, Stefanie Leung, Adrian Dunlop, David Newcombe, Carina Walters, Susanna Galea, Nancy White, Mark Montebello, Apo Demirkol, Nicola Swanson, Robert Ali
INTRODUCTION AND AIMS: Transfer from methadone to buprenorphine is problematic for many opioid-dependent patients, with limited documented evidence or practical clinical guidance, particularly for the range of methadone doses routinely prescribed for most patients (>50 mg). This study aimed to implement and evaluate recent national Australian guidelines for transferring patients from methadone to buprenorphine. DESIGN AND METHODS: A multisite prospective cohort study...
March 5, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29490210/royal-australian-and-new-zealand-college-of-psychiatrists-clinical-practice-guidelines-for-mood-disorders-major-depression-summary
#16
Gin S Malhi, Tim Outhred, Amber Hamilton, Philip M Boyce, Richard Bryant, Paul B Fitzgerald, Bill Lyndon, Roger Mulder, Greg Murray, Richard J Porter, Ajeet B Singh, Kristina Fritz
In December 2015, the Royal Australian and New Zealand College of Psychiatrists published a comprehensive set of mood disorder clinical practice guidelines for psychiatrists, psychologists and mental health professionals. This guideline summary, directed broadly at primary care physicians, is an abridged version that focuses on major depression. It emphasises the importance of shared decision making, tailoring personalised care to the individual, and delivering care in the context of a therapeutic relationship...
March 5, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29488403/more-action-needed-psychotropic-prescribing-in-australian-residential-aged-care
#17
Juanita Westbury, Peter Gee, Tristan Ling, Alex Kitsos, Gregory Peterson
OBJECTIVE: For at least two decades, concerns have been raised about inappropriate psychotropic prescribing in Australian residential aged care facilities, due to their modest therapeutic benefit and increased risk of falls and mortality. To date, the majority of prevalence data has been collected in Sydney exclusively and it is not known if recent initiatives to promote appropriate psychotropic prescribing have impacted utilisation. Thus, we aimed to comprehensively analyse psychotropic use in a large national sample of residential aged care facility residents...
February 1, 2018: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29481765/a-randomised-controlled-trial-of-a-brief-intervention-for-illicit-drug-use-linked-to-assist-screening-in-a-primary-healthcare-setting-results-from-the-australian-component-of-the-world-health-organization-phase-iii-assist-studies
#18
Rachel Humeniuk, David A L Newcombe, Victoria Dennington, Robert Ali
This report presents the findings from the Australian component of the Phase III World Health Organization (WHO) Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) randomised controlled trial investigating the effectiveness of a 5-10-min brief intervention (BI) for illicit drug use delivered in primary healthcare (PHC) settings. Participants (n=171) recruited from a South Australian PHC setting (sexual health clinic) who scored in the 'moderate risk' range on the ASSIST were randomly allocated to an intervention group or wait-list control group at baseline and were followed up 3 months later...
February 27, 2018: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/29476434/complementary-medicines-in-pregnancy-recommendations-and-information-sources-of-healthcare-professionals-in-australia
#19
Christine E Gilmartin, To-Hao Vo-Tran, Laura Leung
Background The use of oral complementary and alternative medicines, including herbal supplements, has been increasing in pregnant women worldwide despite limited safety data. The decision of healthcare professionals to recommend these products to pregnant patients is controversial and not well documented. Objective To explore the recommendations and information sources that healthcare professionals use to determine the safety of oral non-prescribed supplements during pregnancy. Setting An Australian metropolitan maternity hospital...
February 23, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29463336/epidemiology-of-viral-respiratory-infections-in-australian-working-age-adults-20-64-years-2010-2013
#20
B M Varghese, E Dent, M Chilver, S Cameron, N P Stocks
Acute respiratory infections cause significant morbidity and mortality accounting for 5.8 million deaths worldwide. In Australia, influenza-like illness (ILI), defined as cough, fever and fatigue is a common presentation in general practice and results in reduced productivity and lost working days. Little is known about the epidemiology of ILI in working-age adults. Using data from the ASPREN influenza surveillance network in Australia (2010-2013) we found that working-age adults made up 45.2% of all ILI notifications with 55% of samples positive for at least one respiratory virus...
February 21, 2018: Epidemiology and Infection
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