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https://www.readbyqxmd.com/read/29037482/a-low-angiogenic-index-1-plgf-svegfr-1-ratio-at-24-28-weeks-of-gestation-is-a-biomarker-to-identify-the-patient-at-risk-for-subsequent-fetal-death
#1
Tinnakorn Chaiworapongsa, Roberto Romero, Offer Erez, Adi L Tarca, Agustin Conde-Agudelo, Piya Chaemsaithong, Chong Jai Kim, Yeon Mee Kim, Jung-Sun Kim, Bo Hyun Yoon, Sonia S Hassan, Lami Yeo, Steven J Korzeniewski
OBJECTIVE: To determine if maternal plasma concentrations of angiogenic and anti-angiogenic factors measured at 24-28 weeks of gestation can predict subsequent fetal death. METHODS: A case-cohort study was designed to include 1000 randomly selected subjects and all remaining fetal deaths (cases) from a cohort of 4006 women with a singleton pregnancy, enrolled at 6-22 weeks of gestation, in a pregnancy biomarker cohort study. The placentas of all fetal deaths were histologically examined by pathologists who used a standardized protocol and were blinded to patient outcomes...
October 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29034214/pathogenic-cd8-t-cells-cause-increased-levels-of-vegf-a-in-experimental-malaria-associated-acute-respiratory-distress-syndrome-but-therapeutic-vegfr-inhibition-is-not-effective
#2
Thao-Thy Pham, Melissa Verheijen, Leen Vandermosten, Katrien Deroost, Sofie Knoops, Kathleen Van den Eynde, Louis Boon, Chris J Janse, Ghislain Opdenakker, Philippe E Van den Steen
Malaria is a severe disease and kills over 400,000 people each year. Malarial complications are the main cause of death and include cerebral malaria and malaria-associated acute respiratory distress syndrome (MA-ARDS). Despite antimalarial treatment, lethality rates of MA-ARDS are still between 20 and 80%. Patients develop pulmonary edema with hemorrhages and leukocyte extravasation in the lungs. The vascular endothelial growth factor-A (VEGF-A) and the placental growth factor (PlGF) are vascular permeability factors and may be involved in the disruption of the alveolar-capillary membrane, leading to alveolar edema...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29032578/first-trimester-screening-for-pre-eclampsia-in-chinese-pregnancies-case-control-study
#3
Yvonne Kwun Yue Cheng, Tak Yeung Leung, Lai Wa Law, Yuen Ha Ting, Kwok Ming Law, Daljit Singh Sahota
OBJECTIVE: To assess the potential of screening for pre-eclampsia (PE) in a Chinese population. DESIGN: Case Control Study. SETTING: Teaching Hospital in Hong Kong. POPULATION: 3,330 women having a viable singleton pregnancy attending 1(st) trimester Down syndrome screening. METHODS: Mean arterial pressure (MAP), bilateral uterine artery pulsatility index (UtA-PI), and placental growth factor (PlGF) were measured...
October 15, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29031892/altered-angiogenesis-as-a-common-mechanism-underlying-preterm-birth-small-for-gestational-age-and-stillbirth-in-women-living-with-hiv
#4
Andrea L Conroy, Chloe R McDonald, Joel L Gamble, Peter Olwoch, Paul Natureeba, Deborah Cohan, Moses R Kamya, Diane V Havlir, Grant Dorsey, Kevin C Kain
BACKGROUND: Angiogenic processes in the placenta are critical regulators of fetal growth and impact birth outcomes, but there are limited data documenting these processes in HIV-infected women or women from low-resource settings. OBJECTIVE: We sought to determine whether angiogenic factors are associated with adverse birth outcomes in HIV-infected pregnant women started on antiretroviral therapy. STUDY DESIGN: This is a secondary analysis of samples collected as part of a clinical trial randomizing pregnant women infected with HIV to lopinavir/ritonavir-based (n = 166) or efavirenz-based (n = 160) antiretroviral therapy in Tororo, Uganda...
October 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29027018/accelerated-growth-of-hemangioblastoma-in-pregnancy-the-role-of-proangiogenic-factors-and-upregulation-of-hypoxia-inducible-factor-hif-in-a-non-oxygen-dependent-pathway
#5
REVIEW
Yosef Laviv, Joshua L Wang, Matthew P Anderson, Ekkehard M Kasper
Hemangioblastomas (HBs) are benign, highly vascular tumors, often characterized by loss of function of the von Hippel-Lindau (vHL) gene. They are the most common central nervous system tumor observed in vHL syndrome. Loss of function of the vHL gene creates a "pseudo-hypoxic" state, causing overactivation of hypoxia-inducible factor (HIF) and vascular endothelial growth factor (VEGF)-related pathways. In some cases, HBs can rapidly increase in size during pregnancy to then present acutely, which most frequently occurs after the 20th gestational week...
October 13, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29025978/the-anti-vascular-endothelial-growth-factor-receptor-1-monoclonal-antibody-d16f7-inhibits-glioma-growth-and-angiogenesis-in-vivo
#6
Maria Grazia Atzori, Lucio Tentori, Federica Ruffini, Claudia Ceci, Elena Bonanno, Manuel Scimeca, Pedro Miguel Lacal, Grazia Graziani
The vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase receptor that does not play a relevant role in physiological angiogenesis in adults, while it is important in tumor angiogenesis. In high-grade glioma VEGFR-1 expression by tumor endothelium and neoplastic cells contributes to the aggressive phenotype. We recently generated an anti-VEGFR-1 monoclonal antibody (mAb) characterized by a novel mechanism of action, since it hampers receptor activation without interfering with ligand binding...
October 12, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29023811/placental-growth-factor-inhibition-targets-pulmonary-angiogenesis-and-represents-a-novel-therapy-for-hepatopulmonary-syndrome-in-mice
#7
Sarah Raevens, Anja Geerts, Annelies Paridaens, Sander Lefere, Xavier Verhelst, Anne Hoorens, Jo Van Dorpe, Tania Maes, Ken R Bracke, Christophe Casteleyn, Bart Jonckx, Thomas Horvatits, Valentin Fuhrmann, Hans Van Vlierberghe, Christophe Van Steenkiste, Lindsey Devisscher, Isabelle Colle
Hepatopulmonary syndrome (HPS) is a severe complication of cirrhosis with increased risk of mortality. Pulmonary microvascular alterations are key features of HPS, but underlying mechanisms are incompletely understood, and studies on HPS are limited to rats. Placental growth factor (PlGF), a pro-angiogenic molecule that is selectively involved in pathological angiogenesis, may play an important role in HPS development, however, its role has never been investigated. In this study, we validated an HPS model by common bile duct ligation (CBDL) in mice, investigated the kinetic changes in pulmonary angiogenesis and inflammation during HPS development, and provide evidence for a novel therapeutic strategy by targeting pathological angiogenesis...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29017154/screening-performance-of-placental-growth-factor-for-the-prediction-of-low-birth-weight-and-adverse-intrapartum-and-neonatal-outcomes-in-a-term-low-risk-population
#8
Larissa N Bligh, Ristan M Greer, Sailesh Kumar
INTRODUCTION: Fetuses who fail to reach their genetic growth potential are thought to have sub-optimal placental function. Low placental growth factor (PlGF) levels have been shown to be predictive of placentally mediated conditions, such as pre-eclampsia or fetal growth restriction. We investigated the screening performance of PlGF for the prediction of low birth weight (<10th centile for gestation) and adverse intrapartum and neonatal outcomes in apparently low-risk term pregnancies...
October 11, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28992178/tadalafil-improves-l-ng-nitroarginine-methyl-ester-induced-preeclampsia-with-fetal-growth-restriction-like-symptoms-in-pregnant-mice
#9
Kento Yoshikawa, Takashi Umekawa, Shintaro Maki, Michiko Kubo, Masafumi Nii, Kayo Tanaka, Hiroaki Tanaka, Kazuhiro Osato, Yuki Kamimoto, Eiji Kondo, Kenji Ikemura, Masahiro Okuda, Kan Katayama, Takekazu Miyoshi, Hiroshi Hosoda, Ning Ma, Toshimichi Yoshida, Tomoaki Ikeda
BACKGROUND: We investigated the efficacy and mechanisms of tadalafil, a selective phosphodiesterase 5 inhibitor, in treating preeclampsia (PE) with fetal growth restriction (FGR) using L-NG-nitroarginine methyl ester (L-NAME)-induced PE with FGR in pregnant mice as our experimental model. METHODS: C57BL/6 mice were divided into 2 groups 11 days postcoitum (d.p.c.). A control group of dams (C dam) received 0.5% carboxymethylcellulose (CMC). A L-NAME-treated group received 1 mg/ml L-NAME dissolved in CMC...
August 3, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28991900/intra-individual-variability-and-circadian-rhythm-of-vascular-endothelial-growth-factors-in-subjects-with-normal-glucose-tolerance-and-type-2-diabetes
#10
Markolf Hanefeld, Katrin Engelmann, Dieter Appelt, Dirk Sandner, Ingo Weigmann, Xenia Ganz, Frank Pistrosch, Carsta Köhler, Antje Gasparic, Andreas L Birkenfeld
Increased levels of systemic vascular endothelial growth factors (VEGFs) in patients with diabetes are associated with increased risk of microvessel disease. On the other hand, low VEGF levels after intravitreal antibody application may be associated with acute cardiovascular complications and treatment failure. Individual levels of systemic VEGF vary in a wide range depending on analytical methods and quality of diabetes control. So far only limited information exists on intraindividual fluctuations over longer periods and circadian rhythms...
2017: PloS One
https://www.readbyqxmd.com/read/28979997/inhibition-of-placenta-growth-factor-reduces-subretinal-mononuclear-phagocyte-accumulation-in-choroidal-neovascularization
#11
Sergio Crespo-Garcia, Caitlin Corkhill, Christophe Roubeix, Anja-Maria Davids, Norbert Kociok, Olaf Strauss, Antonia M Joussen, Nadine Reichhart
Purpose: The cellular immune response driven by mononuclear phagocytes (MPs) is crucial for choroidal neovascularization (CNV) progression. Case reports show that a switch from pure anti-vascular endothelial growth factor-A (VEGF-A) intravitreal treatment to aflibercept, a drug with combined anti-VEGF-A and anti-placenta growth factor (PlGF) activity, can be beneficial for patients who do not respond to anti-VEGF-A alone. Since MPs harbor VEGFR1, we hypothesize that the interplay of P1GF/vascular endothelial growth factor receptor 1 (VEGFR1) in immune cells plays a pivotal role for CNV...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28978981/galectin-1-as-a-novel-risk-factor-for-both-gestational-hypertension-and-preeclampsia-specifially-its-expression-at-a-low-level-in-the-second-trimester-and-a-high-level-after-onset
#12
Chikako Hirashima, Akihide Ohkuchi, Shiho Nagayama, Hirotada Suzuki, Kayo Takahashi, Manabu Ogoyama, Hironori Takahashi, Koumei Shirasuna, Shigeki Matsubara
Our aim was to evaluate whether the serum level of galectin-1 (Gal-1) at 18-24 and 27-31 weeks of gestation is a risk factor for predicting the later occurrence of not only preeclampsia (PE) but also gestational hypertension (GH). We measured serum levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and Gal-1 using an enzyme-linked immunosorbent assay in 81 and 73 normal pregnant women, 22 and 16 women with a later onset of GH, and 37 and 29 women with a later onset of PE at 18-24 and 27-31 weeks, respectively...
October 5, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28972822/inhibition-of-tgf-%C3%AE-signaling-in-shed-enhances-endothelial-differentiation
#13
J G Xu, T Gong, Y Y Wang, T Zou, B C Heng, Y Q Yang, C F Zhang
Low efficiency of deriving endothelial cells (ECs) from adult stem cells hampers their utilization in tissue engineering studies. The purpose of this study was to investigate whether suppression of transforming growth factor beta (TGF-β) signaling could enhance the differentiation efficiency of dental pulp-derived stem cells into ECs. We initially used vascular endothelial growth factor A (VEGF-A) to stimulate 2 dental pulp-derived stem cells (dental pulp stem cells and stem cells from human exfoliated deciduous teeth [SHED]) and compared their differentiation capacity into ECs...
October 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28965804/neutralization-of-placental-growth-factor-as-a-novel-treatment-option-in-diabetic-retinopathy
#14
Tine Van Bergen, Tjing-Tjing Hu, Isabelle Etienne, Geert E Reyns, Lieve Moons, Jean H M Feyen
The current standard of care in clinical practice for diabetic retinopathy (DR), anti-vascular endothelial growth factor (VEGF) therapy, has shown a significant improvement in visual acuity. However, treatment response can be variable and might be associated with potential side effects. This study was designed to investigate inhibition of placental growth factor (PlGF) as a possible alternative therapy for DR. The effect of the anti-PlGF antibody (PL5D11D4) was preclinically evaluated in various animal models by investigating different DR hallmarks, including inflammation, neurodegeneration, vascular leakage and fibrosis...
September 28, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28964327/performance-of-first-trimester-biochemical-markers-and-mean-arterial-pressure-in-prediction-of-early-onset-pre-eclampsia
#15
Jaana Nevalainen, Teemu Korpimaki, Heikki Kouru, Mikko Sairanen, Markku Ryynanen
OBJECTIVE: To develop a predictive risk model for early-onset pre-eclampsia (EO-PE) using maternal characteristics, combined screening markers, previously reported biomarkers for PE and mean arterial pressure (MAP). METHODS: This retrospective study was conducted at Oulu University hospital between 2006 and 2010. Maternal serum from first trimester combined screening was further analyzed for alpha fetoprotein (AFP), placental growth factor (PlGF), soluble tumor necrosis factor receptor-1 (sTNFR1), retinol binding protein-4 (RBP4), a disintegrin and metalloprotease-12 (ADAM12), soluble P-selectin (sP-selectin), follistatin like-3 (FSTL3), adiponectin, angiopoietin-2 (Ang-2) and sex hormone binding globulin (SHBG)...
October 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28963486/enhanced-hif2%C3%AE-expression-during-human-trophoblast-differentiation-into-syncytiotrophoblast-suppresses-transcription-of-placental-growth-factor
#16
Tatsuya Fujii, Takeshi Nagamatsu, Kazuki Morita, Danny J Schust, Takayuki Iriyama, Atsushi Komatsu, Yutaka Osuga, Tomoyuki Fujii
Placental growth factor (PlGF), abundantly produced from trophoblasts is involved in placental angiogenesis. The regulatory mechanism of its expression is poorly understood. Hypoxia inducible factors (HIFs) are centrally involved in the modulation of cellular function in response to low oxygen conditions. This study aimed to clarify HIF1α and HIF2α expression patterns during cytotrophoblast differentiation into syncytiotrophoblast and the impact of any changes on PlGF expression. HIF proteins were induced remarkably under low oxygen condition (2%)...
September 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28962698/combination-of-copeptin-placental-growth-factor-and-total-annexin-v-microparticles-for-prediction-of-preeclampsia-at-10-14-weeks-of-gestation
#17
Anshul Jadli, Kanjaksha Ghosh, Purnima Satoskar, Kaizad Damania, Vandana Bansal, Shrimati Shetty
INTRODUCTION: Preeclampsia (PE) remains to be an enigmatic puzzle for clinicians and researchers perplexing them for decades. As delivery remains only choice of treatment, early prediction of PE will offer timely therapeutic invention and hence extensive research efforts have been put in identification of biomarkers which will facilitate early prediction of PE. METHODS: Serum levels of CPP, PlGF and plasma total annexin V MPs were assessed in women who subsequently developed PE (n = 33), IUGR (n = 81) and normal pregnancy outcome (n = 112) at 10-14 weeks of gestation...
October 2017: Placenta
https://www.readbyqxmd.com/read/28951939/biological-and-pro-angiogenic-properties-of-genetically-modified-human-primary-myoblasts-overexpressing-placental-growth-factor-in-in-vitro-and-in-vivo-studies
#18
Agnieszka Zimna, Bartosz Wiernicki, Tomasz Kolanowski, Natalia Rozwadowska, Agnieszka Malcher, Wojciech Labedz, Tomasz Trzeciak, Katarzyna Chojnacka, Katarzyna Bednarek-Rajewska, Przemyslaw Majewski, Maciej Kurpisz
Cardiovascular diseases are a growing problem in developing countries; therefore, there is an ongoing intensive search for new approaches to treat these disorders. Currently, cellular therapies are focused on healing the damaged heart by implanting stem cells modified with pro-angiogenic factors. This approach ensures that the introduced cells are capable of fulfilling the complex requirements of the environment, including the replacement of the post-infarction scar with cells that are able to contract and promote the formation of new blood vessels that can supply the ischaemic region with nutrients and oxygen...
September 26, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28942512/altered-endothelial-nitric-oxide-signaling-as-a-paradigm-for-maternal-vascular-maladaptation-in-preeclampsia
#19
REVIEW
George Osol, Nga Ling Ko, Maurizio Mandalà
PURPOSE OF REVIEW: The goal of this review is to present the newest insights into what we view as a central failure of cardiovascular adaptation in preeclampsia (PE) by focusing on one clinically significant manifestation of maternal endothelial dysfunction: nitric oxide signaling. The etiology, symptoms, and current theories of the PE syndrome are described first, followed by a review of the available evidence, and underlying causes of reduced endothelial nitric oxide (NO) signaling in PE...
September 23, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28935154/inducible-knockout-of-syncytin-a-gene-leads-to-an-extensive-placental-vasculature-deficiency-implications-for-preeclampsia
#20
Shan Qiao, Fengchao Wang, Haibin Chen, Shi-Wen Jiang
Syncytin-1, a human endogenous retroviral envelope gene (HERVW1), is specifically expressed in placental trophoblasts and mediates the formation of syncytiotrophoblasts through a fusogenic activity. Syncytin-1 expression deficiency has been repeatedly observed in preeclamptic/IUGR placentas. Previous gene knockout studies indicated that in mice, complete syncytin-A null mouse embryos died in utero between 11.5 and 13.5days of gestation. However, the complete knockout model could not fully recapitulate the mid- to third-trimester, time-specific syncytin-1 deficiency in preeclampsia patients...
November 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
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