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https://www.readbyqxmd.com/read/29467515/infant-size-and-the-association-between-maternal-circulating-angiogenic-factors-and-preeclampsia
#1
Michael C Honigberg, Ellen W Seely, Ann M Thomas, Kee-Hak Lim, Samuel Parry, Thomas F McElrath
OBJECTIVE: To assess the effect of infant size as a marker of placental function on the association between preeclampsia and the ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF). STUDY DESIGN: The angiogenic factors sFlt-1 and PlGF were measured prospectively at 26 weeks gestation in 2322 women. Pregnancies were stratified by whether or not they were complicated by preeclampsia, the timing of delivery, and birthweight Z-score...
February 21, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29455633/placental-growth-factor-vascular-endothelial-growth-factor-and-hypoxia-inducible-factor-1%C3%AE-in-the-placentas-of-women-with-preeclampsia
#2
Lobna E Ali, Magdi M Salih, Elhassan M Elhassan, Ahmed A Mohmmed, Ishag Adam
BACKGROUND: Although the exact mechanism of preeclampsia - high blood pressure and proteinuria after 20 gestational weeks - is not yet fully understood, placental growth factor (PLGF), vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF) are known to play important roles in vascularization and in the pathology of preeclampsia. METHODS: PLGF, VEGF and HIF-1α were evaluated by immunohistochemistry in the placentas of Sudanese women with mild or severe preeclampsia, and in normal controls...
February 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29439617/low-density-lipoprotein-receptor-related-protein-6-is-essential-for-trophoblast-survival-and-invasion
#3
Lei Li, Jipeng Wan, Jing Xue, Hongyan Li, Shan Wang, Qian Zhou, Yu Zhou, Xietong Wang
Remodeling of maternal spiral artery after the implantation of embryo relies on tightly regulated trophoblast functions and is pivotal to ensure the success of pregnancy. Low-density lipoprotein receptor-related protein 6 (LRP6) is implicated in angiogenesis and several vascular diseases, but its function in trophoblast regulation is still not fully understood. We aimed to investigate the involvement of LRP6 in trophoblast functions during maternal spiral artery remodeling. HTR-8/SVneo cells, a trophoblast cell line, were employed to examine the impact of LRP6 knockdown on proliferation, apoptosis, and migration, as well as invasion and tube formation...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29434073/placental-growth-factor-plgf-is-linked-to-inflammation-and-metabolic-disorders-in-mice-with-diet-induced-obesity
#4
Mincheol Kang, Jain Jeong, Jinhee Lee, Song Park, Yonghun Sung, Minjee Choi, Wookbong Kwon, Soyoung Jang, Kwang Shik Choi, Yeon Sik Choo, Duhak Yoon, Myoung Ok Kim, Zae Young Ryoo
Placental growth factor (PlGF), a member of the vascular endothelial growth factor (VEGF) sub-family, plays a major role in angiogenesis and vasculogenesis. Previous study demonstrated that PlGF-overexpressing transgenic (Tg) mice had gestational loss. In addition, PlGF secretion was up-regulated in isolated T lymphocytes (T-cell) upon CD3/CD28 stimulation, suggesting that PlGF could be a regulator of T-cell differentiation and development. T-cells are well known to play a critical role in obesity-induced inflammation...
February 9, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29432537/the-nerve-of-the-spleen-causing-hypertension-by-plgf
#5
Justin P Van Beusecum, David G Harrison
No abstract text is available yet for this article.
February 8, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29416013/mir-143-3p-targeting-of-itga6-suppresses-tumour-growth-and-angiogenesis-by-downregulating-plgf-expression-via-the-pi3k-akt-pathway-in-gallbladder-carcinoma
#6
Yun-Peng Jin, Yun-Ping Hu, Xiang-Song Wu, Yao-Shi Wu, Yuan-Yuan Ye, Huai-Feng Li, Yong-Chen Liu, Lin Jiang, Fa-Tao Liu, Yi-Jian Zhang, Ya-Juan Hao, Xi-Yong Liu, Ying-Bin Liu
Gallbladder cancer (GBC) is the most common malignant tumour of the biliary track system. Angiogenesis plays a pivotal role in the development and progression of malignant tumours. miR-143-3p acts as a tumour suppressor in various cancers. Their role in GBC is however less well defined. Here we show that the expression levels of miR-143-3p were decreased in human GBC tissues compared with the non-tumour adjacent tissue (NAT) counterparts and were closely associated with overall survival. We discovered that miR-143-3p was a novel inhibitor of tumour growth and angiogenesis in vivo and in vitro...
February 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29395656/serum-protein-marker-panel-for-predicting-preeclampsia
#7
Lifeng Cui, Chang Shu, Zitao Liu, Weihua Tong, Miao Cui, Chengguo Wei, Jian Jenny Tang, Xiufen Liu, Hujing Hai, Jing Jiang, Jin He, David Y Zhang, Fei Ye, Yulin Li
BACKGROUND: Preeclampsia is a multi-system disorder in pregnancy which has no effective treatment. The diagnosis of preeclampsia is based on clinical presentation and routine laboratory tests. OBJECTIVE: This study aimed at identifying serum protein markers for diagnosis of preeclampsia and predicting its severe features. STUDY DESIGN: In total, 172 pregnant women were enrolled in this study including 110 subjects with preeclampsia and 62 normotensive subjects...
January 29, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29392826/reduced-angiogenic-factor-expression-in-intrauterine-fetal-growth-restriction-using-semiquantitative-immunohistochemistry-and-digital-image-analysis
#8
Thushari I Alahakoon, Weiyi Zhang, Susan Arbuckle, Kewei Zhang, Vincent Lee
AIM: To localize, quantify and compare angiogenic factors, vascular endothelial growth factor (VEGF), placental growth factor (PlGF), as well as their receptors fms-like tyrosine kinase receptor (Flt-1) and kinase insert domain receptor (KDR) in the placentas of normal pregnancy and complications of preeclampsia (PE), intrauterine fetal growth restriction (IUGR) and PE + IUGR. METHODS: In a prospective cross-sectional case-control study, 30 pregnant women between 24-40 weeks of gestation, were recruited into four clinical groups...
February 1, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29376143/bevacizumab-injection-in-patients-with-neovascular-age-related-macular-degeneration-increases-angiogenic-biomarkers
#9
Thiago Cabral, Luiz H Lima, Luiz Guilherme M Mello, Júlia Polido, Éverton P Correa, Akiyoshi Oshima, Jimmy Duong, Pedro Serracarbassa, Caio V Regatieri, Vinit B Mahajan, Rubens Belfort
Purpose: To evaluate the expression of 19 angiogenic biomarkers in the aqueous humor before and after intravitreal bevacizumab injection (IVB) in eyes with neovascular age-related macular degeneration (AMD). Design: Prospective, noncomparative, interventional case series. Participants: Twenty-three eyes of 23 treatment-naïve patients with choroidal neovascularization (CNV) secondary to neovascular AMD. Methods: Eyes were diagnosed with CNV secondary to neovascular AMD and were treated with 3 monthly IVBs...
January 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/29370571/an-intraocular-inflammatory-profile-of-rubella-associated-uveitis
#10
Z Fazil, J C Ten Berge, A W Langerak, A Rothova, W A Dik
PURPOSE: To analyze intraocular cytokine levels and cell profiles in patients with rubella virus-associated uveitis (RVU). METHODS: We collected intraocular fluid samples from patients with RVU (n = 10), uveitis of other causes (n = 27), and cataract (n = 22). Levels of 15 cytokines (IL-1β, IL-1ra, IL-2, IL-6, IL-6rα, IL-7, IL-8, IL-10, IL-17A, IL-23, TARC, MCP-1, TNF-α, PlGF, and VEGF) were measured using multiplex assay, and intraocular cell populations were determined by multiparameter flowcytometry...
January 25, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29337222/blockade-of-placental-growth-factor-reduces-vaso-occlusive-complications-in-murine-models-of-sickle-cell-disease
#11
Jian-Ming Gu, Shujun Yuan, Derek Sim, Keith Abe, Perry Liu, Martin Rosenbruch, Peter Bringmann, Katalin Kauser
Vaso-occlusive crisis (VOC) is the most common and debilitating complication of sickle cell disease (SCD); recurrent episodes cause organ damage and contribute to early mortality. Plasma placental growth factor (PlGF) levels are elevated in SCD and can further increase under hypoxic conditions in SCD mice. Treatment with a PlGF-neutralizing antibody (anti-PlGF Ab) in SCD mice reduced levels of monocyte chemoattractant protein-3, eotaxin, macrophage colony-stimulating factor, plasminogen activator inhibitor-1 significantly, and macrophage-derived chemokine and macrophage inflammatory protein-3β moderately; this may contribute to inhibition of leukocyte recruitment, activation, and thrombosis...
January 11, 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29325073/the-women-s-health-diagnostic-gap
#12
Ann M Gronowski, Melanie L Yarbrough
Pregnancy remains a significant health risk to women in both developed and underdeveloped countries. Worldwide, 10 to 20 million women have pregnancy complications including ectopic pregnancy, preterm birth, gestational diabetes mellitus, and hypertensive states, including preeclampsia. Despite advancements in women's health research, there is a large gap in the diagnostic tools available to screen, diagnose, and monitor these conditions. Herein, we examine existing diagnostic tools, such as the human chorionic gonadotropin discriminatory zone, cervicovaginal fetal fibronectin, sFlt-1:PlGF ratio, and glucose tolerance testing...
February 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29324984/doca-salt-hypertension-activates-plgf-in-the-spleen-to-couple-sympathetic-drive-and-immune-system-activation
#13
Marialuisa Perrotta, Andrea Lori, Lorenzo Carnevale, Stefania Fardella, Giuseppe Cifelli, Roberta Iacobucci, Francesco Mastroiacovo, Daniele Iodice, Fabio Pallante, Marianna Storto, Giuseppe Lembo, Daniela Carnevale
Aims: Chronic increase of mineralocorticoids obtained by administration of Deoxycorticosterone acetate (DOCA) results in salt dependent hypertension in animals. Despite the lack of a generalized sympathoexcitation, DOCA-salt hypertension has been also associated to overdrive of peripheral nervous system in organs typically targeted by blood pressure (BP), as kidneys and vasculature. Aim of this study was to explore whether DOCA-salt recruits immune system by overactivating sympathetic nervous system in lymphoid organs and whether this is relevant for hypertension...
January 8, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29318732/association-between-fetal-fraction-on-cell-free-dna-testing-and-first-trimester-markers-for-pre-eclampsia
#14
Daniel L Rolnik, Fabricio da Silva Costa, Timothy J Lee, Maximilian Schmid, Andrew C McLennan
AIMS: To evaluate the association of fetal fraction on cell-free DNA (cfDNA) testing with first trimester markers for pre-eclampsia and to investigate a possible association of low fetal fraction with increased risk for pre-eclampsia (PE) and fetal growth restriction (FGR). METHODS: This was a retrospective cohort study including all women with singleton pregnancies who had risk calculation for PE and FGR between 11+0 and 13+6 weeks' gestation and also decided to have cfDNA as a primary or secondary screening test for chromosomal abnormalities at any gestational age in two Fetal Medicine clinics in Sydney and Melbourne, Australia, between March 2013 and May 2017...
January 10, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29308696/early-pregnancy-protein-multiplex-screening-reflects-circulating-and-urinary-divergences-associated-with-the-development-of-preeclampsia
#15
Margarita L Martinez-Fierro, Claudia Castruita-De La Rosa, Idalia Garza-Veloz, Rosa M Cardiel-Hernandez, Marcela A Espinoza-Juarez, Ivan Delgado-Enciso, Maria E Castañeda-Lopez, Edith Cardenas-Vargas, Fabiola Trejo-Vázquez, Elma I Sotelo-Ham, Rodrigo Castañeda-Miranda, Miguel A Cid-Baez, Jose M Ortiz-Rodriguez, Luis O Solis-Sanchez, Angelica Garcia Aviles, Yolanda Ortiz-Castro
BACKGROUND: Preeclampsia, a pregnancy disorder characterized by hypertension and proteinuria, represents the leading cause of fetal and maternal morbidity and mortality in developing countries. The identification of novel and accurate biomarkers that are predictive of preeclampsia is necessary to improve the prognosis of patients with preeclampsia. OBJECTIVE: To evaluate the preeclampsia predictive value of 34 angiogenic-related proteins. METHODS: We performed a nested cohort case-control study of pregnant women...
January 8, 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29295851/proteomic-profiling-for-cardiovascular-biomarker-discovery-in-orthostatic-hypotension
#16
Madeleine Johansson, Fabrizio Ricci, Nay Aung, Richard Sutton, Olle Melander, Artur Fedorowski
Orthostatic hypotension (OH) has been linked with higher incidence of cardiovascular disease, but little is known about the mechanisms behind this association. We aimed to identify cardiovascular disease biomarkers associated with OH through a proteomic profiling approach. Seven hundred seventy-eight patients with unexplained syncope or orthostatic intolerance underwent head-up tilt test and supine blood samples. Of these, 220 met diagnostic criteria of OH, and 179 demonstrated normal hemodynamic response during head-up tilt test...
January 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29294516/-the-effect-of-captopril-and-losartan-on-paraquat-induced-pulmonary-fibrosis-and-plgf-expression-in-the-lungs-of-rats
#17
M H Zheng, M S Dai, L F Lin
Objective: To investigate the dynamic expression of placenta growth factor (PlGF) in the lungs and its role in paraquat-induced pulmonary fibrosis and to evaluate the effect of ACEI captopril and AT (1) -receptor blocker losartan on paraquat-induced pulmonary fibrosis. Methods: 84 adult healthy female Sprague-Dawley (SD) rats were randomly divided into four groups of different treatments designated as: Control, PQ alone (PQ) , captopril treatment, losartan treatment. Each group was divided into three subgroups of seven animals each...
September 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29284120/colorimetric-immunoassays-for-the-screening-and-specificity-evaluation-of-molecules-disturbing-vegfs-vegfrs-interactions
#18
Laura Trapiella-Alfonso, Sylvain Broussy, Wang-Qing Liu, Michel Vidal, Edouard Lecarpentier, Vassilis Tsatsaris, Nathalie Gagey-Eilstein
Angiogenesis and its involved proteins, particularly Vascular Endothelial Growth Factor (VEGF) family and VEGF receptors (VEGFRs), have been considered as a target of therapeutic interest for numerous inflammatory and vascular diseases. Acting on this biological process through interaction with VEGFs or VEGFRs has received considerable attention. Indeed, VEGFs and VEGFRs are currently targeted by drugs such as monoclonal antibodies. The feasibility of a therapeutic strategy based on blocking the VEGF/VEGFR interaction by using ligands "other-than-biologics" is also explored...
December 25, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29277778/placental-growth-factor-in-bladder-cancer-compared-to-the-diagnostic-accuracy-and-prognostic-performance-of-vascular-endothelial-growth-factor-a
#19
Viktor Soukup, Otakar Čapoun, Michael Pešl, Roman Sobotka, Lucie Vávřová, Tomáš Hanuš, Tomáš Zima, Marta Kalousová
BACKGROUND/AIM: To evaluate the diagnostic accuracy and prognostic performance of urinary and plasma levels of placental growth factor (PLGF) and provide their comparison with the results of vascular endothelial growth factor A (VEGF-A) in patients with primary and recurrent urinary bladder cancer. MATERIALS AND METHODS: The enzyme-linked immunosorbent assay (ELISA) was used to assess urinary and plasma concentrations of PLGF and VEGF-A in 240 individuals. RESULTS: PLGF levels in urine and plasma were significantly higher in patients with primary bladder cancer than in healthy individuals (p=0...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277266/changes-in-maternal-placental-growth-factor-levels-during-term-labour
#20
Liam Dunn, Christopher Flatley, Sailesh Kumar
Placental growth factor (PlGF) has important angiogenic function that is critical to placental development. Lower levels of PlGF are associated with fetal growth restriction, pre-eclampsia and intrapartum fetal compromise. The aim of this study was to investigate the effect of labour on maternal PlGF levels. METHOD: This was a prospective observational cohort study. Normotensive women with a singleton, normally grown, non-anomalous, fetus between 37 + 0 and 42 + 0 weeks gestation were eligible for inclusion...
January 2018: Placenta
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