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https://www.readbyqxmd.com/read/28640960/ferulic-acid-alleviates-symptoms-of-preeclampsia-in-rats-by-upregulating-vascular-endothelial-growth-factor
#1
Weiyan Gong, Jipeng Wan, Qing Yuan, Quanzhan Man, Xiaojing Zhang
Preeclampsia is a complication affecting pregnant women worldwide, which leads to maternal and fetal morbidity and mortality. In this study, we evaluated the efficacy of ferulic acid (FA) on an N(ω) -nitro-L-arginine methyl ester hydrochloride (L-NAME) induced rat model of preeclampsia. L-NAME was administered to pregnant rats to induce preeclampsia. 48 rats were divided into three experimental groups (n=16 each): control group, preeclampsia group and preeclampsia with FA treatment (preeclampsia+FA). Physiological characteristics such as urine volume, total urine protein and blood pressure were assessed...
June 22, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28635072/plgf-enhances-tlr-dependent-inflammatory-responses-in-human-mononuclear-phagocytes
#2
Laura F Newell, Shernan G Holtan, Jane E Yates, Leonardo Pereira, Jeffrey W Tyner, Irina Burd, Grover C Bagby
PROBLEM: Levels of placental growth factor (PlGF) peak during third trimester of pregnancy, a time when women are at increased risk of virus-induced morbidity. We hypothesized PlGF might contribute to an exaggerated inflammatory response to Toll-like receptor (TLR) activation. METHOD OF STUDY: Primary human adult and cord blood CD14(+) cells were cultured in the presence of TLR ligands and/or PlGF. RESULTS: PlGF significantly enhanced the magnitude and duration of TNF messenger RNA and protein production by TLR-7/8-activated monocytes, and increased subsequent production of TNF-independent inflammatory cytokines...
June 20, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28627965/role-of-angiopoietin-2-endoglin-and-placental-growth-factor-in-hiv-associated-preeclampsia
#3
Nokuzola Mbhele, Jagidesa Moodley, Thajasvarie Naicker
OBJECTIVE: The factors angiopoeitin-2 (Ang-2), endoglin (Eng), and placental growth factor (PlGF) have been implicated in the pathophysiology of preeclampsia (PE). This study assessed their serum levels in HIV-negative and HIV-positive pregnant normotensive and pre-eclamptic women. METHODS: Participants were recruited at the antenatal clinic, serum samples were evaluated using the Bioplex Human Cancer Biomarker (panel 2). RESULTS: Ang-2 and Eng levels were higher, whilst PlGF levels were lower in the PE compared with the normotensive group...
June 19, 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/28627818/maternal-serum-plgf-pappa-%C3%AE-hcg-and-afp-levels-in-early-second-trimester-as-predictors-of-preeclampsia
#4
Honglei Duan, Guangfeng Zhao, Biyun Xu, Suwei Hu, Jie Li
BACKGROUND: Identifying women at risk of preeclampsia (PE) by maternal serum screening is conducive to prompt gestational management and thereby improve both maternal and perinatal outcomes. The purpose of the present study was to evaluate the association between the concentrations of maternal serum placental growth factor (PLGF), pregnancy associated plasma protein-A (PAPPA), free β-human chorionic gonadotropin (β-hCG), and αFetoprotein (AFP) and the development of preeclampsia early in the second trimester...
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28613385/expanded-conventional-first-trimester-screening
#5
Jonathan B Carmichael, Hsiao-Pin Liu, David Janik, Terrence W Hallahan, Kypros H Nicolaides, David A Krantz
OBJECTIVE: To determine the performance of a five (5) serum marker plus ultrasound screening protocol for T21, T18 and T13. METHOD: Specimens from 331 unaffected, 34 T21, 19 T18 and 8 T13 cases were analyzed for free Beta hCG, PAPP-A, AFP, PlGF and dimeric inhibin A (DIA). Gaussian distributions of MoM values were used to estimate modeled false positive and detection rates. RESULTS: For T21, at a 1/300 risk cut-off, detection rate of screening with all five serum markers along with nuchal translucency and nasal bone was 98% at a 1...
June 14, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28613009/independent-risk-factors-for-a-small-placenta-and-a-small-for-gestational-age-infant-at-35-41%C3%A2-weeks-of-gestation-an-association-with-circulating-angiogenesis-related-factor-levels-at-19-31%C3%A2-weeks-of-gestation
#6
Chikako Hirashima, Akihide Ohkuchi, Kayo Takahashi, Hirotada Suzuki, Koumei Shirasuna, Shigeki Matsubara
AIM: Our aim was to investigate the effects of angiogenesis-related factor levels at 19-25 and 26-31 weeks of gestation (WG) on the later occurrence of a small-for-gestational-age (SGA) placenta (small placenta) or an SGA infant delivered at 35-41 WG. METHODS: We measured plasma levels of soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF), and the serum level of soluble endoglin (sEng) in 679 pregnant women with blood sampling at both 19-25 and 26-31 WG in a prospective study...
June 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28609172/placental-expression-of-sflt-1-and-plgf-in-early-preeclampsia-vs-early-iugr-vs-age-matched-healthy-pregnancies
#7
Alice Hoeller, Laura Ehrlich, Michaela Golic, Florian Herse, Frank H Perschel, Monika Siwetz, Wolfgang Henrich, Ralf Dechend, Berthold Huppertz, Stefan Verlohren
OBJECTIVE: To investigate whether differences between early preeclampsia and early fetal growth restriction can be explained by differential placental expression patterns of sFlt-1, Flt-1, and PlGF. METHODS: Placental tissues and maternal blood samples from six cases of preeclampsia, seven IUGR, and six age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity. RESULTS: Neither placental PlGF mRNA and protein expression nor placental villous trophoblast expression intensity of PlGF was altered by placental dysfunction...
May 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/28607365/neuropilin-1-associated-molecules-in-the-blood-distinguish-poor-prognosis-breast-cancer-a-cross-sectional-study
#8
Adviti Naik, Noura Al-Zeheimi, Charles Saki Bakheit, Marwa Al Riyami, Adil Al Jarrah, Mansour S Al Moundhri, Zamzam Al Habsi, Maysoon Basheer, Sirin A Adham
Circulating plasma and peripheral blood mononuclear (PBMCs) cells provide an informative snapshot of the systemic physiological state. Moreover, they provide a non-invasively accessible compartment to identify biomarkers for personalized medicine in advanced breast cancer. The role of Neuropilin-1 (NRP-1) and its interacting molecules in breast tumor tissue was correlated with cancer progression; however, the clinical impact of their systemic levels was not extensively evaluated. In this cross-sectional study, we found that circulating and tumor tissue expression of NRP-1 and circulating placental growth factor (PlGF) increase in advanced nodal and metastatic breast cancer compared with locally advanced disease...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28600845/sflt-1-and-plgf-kinetics-during-and-after-pregnancy-in-women-with-suspected-or-confirmed-preeclampsia
#9
Langeza Saleh, Anton H van den Meiracker, Roos Geensen, Aslihan Kaya, Jeanine E Roeters van Lennep, Johannes J Duvekot, Koen Verdonk, Eric A P Steegers, Henk Russcher, Jan A H Danser, Willy Visser
OBJECTIVES: To assess the evolution of the sFlt-1/PlGF ratio in women with suspected or with confirmed preeclampsia and to investigate the changes in sFlt-1 and PlGF levels in preeclamptic women after delivery. METHODS: In this exploratory tertiary referral university centre study, using the Roche Diagnostics Elecsys assay, sFlt-1 and PlGF were determined in two groups of patients. In the first group of 46 patients with suspected or confirmed preeclampsia, sFlt-1 and PlGF were measured at least twice during their pregnancy...
June 10, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28587682/plgf-a-placental-marker-of-fetal-brain-defects-after-in-utero-alcohol-exposure
#10
Matthieu Lecuyer, Annie Laquerrière, Soumeya Bekri, Céline Lesueur, Yasmina Ramdani, Sylvie Jégou, Arnaud Uguen, Pascale Marcorelles, Stéphane Marret, Bruno J Gonzalez
Most children with in utero alcohol exposure do not exhibit all features of fetal alcohol syndrome (FAS), and a challenge for clinicians is to make an early diagnosis of fetal alcohol spectrum disorders (FASD) to avoid lost opportunities for care. In brain, correct neurodevelopment requires proper angiogenesis. Since alcohol alters brain angiogenesis and the placenta is a major source of angiogenic factors, we hypothesized that it is involved in alcohol-induced brain vascular defects. In mouse, using in vivo repression and overexpression of PLGF, we investigated the contribution of placenta on fetal brain angiogenesis...
June 6, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28580450/expression-of-placental-growth-factor-mrna-in-preeclampsia
#11
Pooneh Nikuei, Minoo Rajaei, Kianoosh Malekzadeh, Azim Nejatizadeh, Fatemeh Mohseni, Fatemeh Poordarvishi, Nasrin Ghashghaeezadeh, Mehrdad Mohtarami
BACKGROUND: Preeclampsia (PE) is a serious complication of pregnancy with hallmarks of incomplete placentation, placental ischemia and endothelial dysfunction. Imbalance between vascular endothelial growth factor (VEGF), placenta growth factor (PlGF) and their receptors play important role in pathophysiology of PE. OBJECTIVE: This study was aimed to asses PlGF mRNA expression in placenta of women affected with PE. MATERIAL AND METHODS: In this cross-sectional study, expression of PlGF mRNA was evaluated in 26 mild PE cases, 15 severe preeclamptic women and 20 normotensive controls...
March 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28575932/household-air-pollution-and-angiogenic-factors-in-pregnant-nigerian-women-a-randomized-controlled-ethanol-cookstove-intervention
#12
Anindita Dutta, Katherine Brito, Galina Khramstova, Ariel Mueller, Sireesha Chinthala, Donee Alexander, Damilola Adu, Tope Ibigbami, John Olamijulo, Abayomi Odetunde, Kehinde Adigun, Liese Pruitt, Olufunmilayo Olopade, Oladosu Ojengbede, Sarosh Rana, Christopher O Olopade
BACKGROUND: Maternal exposure to ambient air pollution affects placental growth markers. OBJECTIVES: Investigate impact of household air pollution (HAP) on placental growth markers. METHODS: Two groups of pregnant women were identified: firewood/kerosene stove-users (A, n=33) and bioethanol stove-users (B, n=44) that participated in a randomized control trial in Ibadan, Nigeria. A third group of non-smoking and presumed liquefied petroleum gas-using Chicago women (C, n=19) were included in this exploratory pilot to assess for possible differences between similar racial groups...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28571908/the-sflt-1-plgf-ratio-as-a-predictor-for-poor-pregnancy-and-neonatal-outcomes
#13
Yu-Shan Chang, Chi-Nien Chen, Suh-Fang Jeng, Yi-Ning Su, Chien-Yi Chen, Hung-Chieh Chou, Po-Nien Tsao, Wu-Shiun Hsieh
BACKGROUND: Soluble fms-like tyrosine kinase receptor-1 (sFlt-1)/placental growth factor (PlGF) ratio has been studied extensively as a predictive marker for pre-eclampsia. However, its usefulness for predicting neonatal outcomes remains unknown. This study aimed to evaluate the association of sFlt-1/PlGF ratio with pregnancy outcomes, neonatal morbidities and short-term postnatal growth patterns in pregnant women and their babies. METHODS: sFlt-1 and PlGF were measured in women with fetal intrauterine growth retardation (IUGR) or pre-eclampsia during gestational age (GA) of 16-36 weeks...
May 10, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28569565/prediction-of-preeclampsia-in-primigravida-in-late-first-trimester-using-serum-placental-growth-factor-alone-and-by-combination-model
#14
Rachna Agarwal, Shweta Chaudhary, Rajarshi Kar, Gita Radhakrishnan, Anupama Tandon
We investigated a placental growth factor alone and combined clinical (mean arterial pressure, MAP), biophysical (uterine artery pulsability index, PI) and biochemical (placental growth factor, PLGF) model for predicting preeclampsia in late first trimester. The inclusion criteria was primigravida (<40 years) attending their first hospital visit with singleton pregnancy at 11-14 weeks of gestation. Of the enrolled and followed 291 subjects, 35 (12%) later developed PE (5.8%)/GH (6.2%). An equal number of randomised women with normotensive non-proteinuric course were considered as reference group...
June 1, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28564655/aqueous-humor-levels-of-soluble-vascular-endothelial-growth-factor-receptor-and-inflammatory-factors-in-diabetic-macular-edema
#15
Hidetaka Noma, Tatsuya Mimura, Kanako Yasuda, Ryosuke Motohashi, Osamu Kotake, Masahiko Shimura
Aqueous levels of soluble vascular endothelial growth factor receptor (sVEGFR) and inflammatory factors were measured in 35 patients (37 eyes) with diabetic macular edema (DME) receiving anti-vascular endothelial growth factor (VEGF) therapy. Aqueous levels of growth factors (VEGF, placental growth factor [PlGF], and platelet-derived growth factor AA [PDGF-AA]), sVEGFR-1 and -2, soluble intercellular adhesion molecule 1, monocyte chemotactic protein (MCP)-1, interleukin (IL)-6, -8, -12, and -13, and interferon-inducible 10-kDa protein (IP-10) were significantly higher in the DME group than in the nondiabetic control group...
June 1, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28556556/competing-risks-model-in-screening-for-preeclampsia-in-twin-pregnancies-by-maternal-factors-and-biomarkers-at-11-13-weeks-gestation
#16
Carla Francisco, David Wright, Zsófia Benkő, Argyro Syngelaki, Kypros H Nicolaides
OBJECTIVE: To develop a model for preeclampsia (PE) in twin pregnancies based on maternal demographic characteristics and medical history and biomarkers at 11-13 weeks' gestation. METHODS: This was a screening study in twin pregnancies at 11-13 weeks' gestation. Bayes theorem was used to combine the a priori risk from maternal factors with various combinations of uterine artery pulsatility index (UTPI), mean arterial pressure (MAP), serum pregnancy associated plasma protein-A (PAPP-A) and placental growth factor (PLGF) multiple of the median (MoM) values...
May 27, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28552862/imbalanced-angiogenesis-in-peripartum-cardiomyopathy%C3%A3-diagnostic-value-of-placenta-growth-factor
#17
Alexandre Mebazaa, Marie-France Seronde, Etienne Gayat, Kemi Tibazarwa, Dilly O C Anumba, Najla Akrout, Malha Sadoune, Jamela Sarb, Mattia Arrigo, Justina Motiejunaite, Said Laribi, Matthieu Legrand, Lydia Deschamps, Loubina Fazal, Lila Bouadma, Corinne Collet, Philippe Manivet, Alain Cohen Solal, Jean-Marie Launay, Jane-Lise Samuel, Karen Sliwa
BACKGROUND: Concentrations of the anti-angiogenic factor soluble fms-like tyrosine kinase-1 (sFlt-1) are altered in peripartum cardiomyopathy (PPCM). In this study we investigated changes in the angiogenesis balance in PPCM.Methods and Results:Plasma concentrations of sFlt-1 and the pro-angiogenic placenta growth factor (PlGF) were determined in patients with PPCM during the post-partum phase (n=83), in healthy women at delivery (n=30), and in patients with acute heart failure (AHF; n=65)...
May 27, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28537456/angiogenic-profile-and-smoking-in-the-finnish-genetics-of-pre-eclampsia-consortium-finnpec-cohort
#18
Tiina Jääskeläinen, Sanna Suomalainen-König, Esa Hämäläinen, Kari Pulkki, Jarkko Romppanen, Seppo Heinonen, Hannele Laivuori
OBJECTIVES: The biological mechanism by which smoking reduces the risk of pre-eclampsia (PE) is unresolved. We studied serum levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and their ratio, in addition to soluble endoglin (sEng) in early and late pregnancy to ascertain whether these factors are altered in women who smoke. SUBJECTS AND METHODS: First trimester serum samples were available from 217 women who later developed PE and 238 women who did not develop PE...
June 9, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28514925/factors-affecting-cell-free-dna-fetal-fraction-and-the-consequences-for-test-accuracy
#19
Fergus Perry Scott, Melody Menezes, Ricardo Palma-Dias, Debbie Nisbet, Philip Schluter, Fabricio da Silva Costa, Andrew Cameron McLennan
INTRODUCTION: Biological factors are known to influence the fetal fraction (FF) of cell-free DNA and may also influence the accuracy of non-invasive prenatal testing. MATERIAL AND METHODS: NIPT from 5,267 mixed risk women across three specialist clinics in Australia were analysed. Multivariable regression analysis was used to determine whether maternal characteristics, ultrasound and placental biomarkers affect FF and test accuracy. RESULTS: FF ranged from 4% - 37% (mean 11...
May 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28501276/diagnosis-of-preeclampsia-and-fetal-growth-restriction-with-the-sflt-1-plgf-ratio-diagnostic-accuracy-of-the-automated-immunoassay-kryptor%C3%A2
#20
Lisa Antonia Dröge, Alice Höller, Laura Ehrlich, Stefan Verlohren, Wolfgang Henrich, Frank Holger Perschel
OBJECTIVE: We aimed to characterize the diagnostic accuracy of the Kryptor® assay for sFlt-1 and PlGF in maternal serum samples of uneventful singleton pregnancies and subjects with preeclampsia (PE) and PE-related outcomes such as fetal growth restriction (FGR). Longitudinal reference ranges of the sFlt-1 and PlGF level in the course of normal pregnancies were generated. METHODS: A cohort of subjects with PE and PE-related outcomes including FGR in the third trimester was compared to a cohort of women with uneventful outcome...
April 2017: Pregnancy Hypertension
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