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https://www.readbyqxmd.com/read/28529572/recurrent-female-adnexal-tumor-of-probable-wolffian-origin-treated-with-debulking-surgery-imatinib-and-paclitaxel-carboplatin-combination-chemotherapy-a-case-report
#1
Akihiko Wakayama, Hirofumi Matsumoto, Hajime Aoyama, Masanao Saio, Ayumi Kumagai, Takuma Ooyama, Morihiko Inamine, Yoichi Aoki
In view of the small number of recurrent and metastatic cases of female adnexal tumors of probable Wolffian origin (FATWO), there is a distinct lack of evidence to support recommendations regarding treatment. In the present study, a 37-year-old female was diagnosed with a left adnexal tumor and underwent a left salpingo-oophorectomy (SO). The tumor was found to arise from the left tubal fimbria and extend to the posterior leaf of the broad ligament. Pathological examination identified a number of solid, tubular and cystic architectures, with areas of hyalinization, hemorrhage and necrosis...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28529267/endometrial-adenocarcinoma-with-choriocarcinomatous-differentiation-in-the-uterus-of-a-goat
#2
Masashi Kawashima, Risa Segawa, Toshinori Yoshida, Hirotada Murayama, Rei Nagahara, Masayuki Kimura, Natsumi Endo, Tomomi Tanaka, Makoto Shibutani
An 11-year-old female goat had invasive and metastatic endometrial adenocarcinoma in the uterus. There was a notable proliferation of endometrial epithelial cells in a tubular growth pattern, with a desmoplastic response. The endometrial epithelial tumor cells metastasized to the kidney, liver and lung. In contrast to the primary and metastatic tumor cells, pleomorphic tumor cells with a choriocarcinoma-like growth pattern infiltrated the mesometrium. Cell proliferation activity was high in both types of tumor cells...
May 19, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28522409/neonatal-exposure-to-17%C3%AE-ethynyl-estradiol-ee-disrupts-follicle-development-and-reproductive-hormone-profiles-in-female-rats
#3
Haolin Zhang, Kazuyoshi Taya, Kentaro Nagaoka, Midori Yoshida, Gen Watanabe
Toxic effects induced by exposure to endocrine-disrupting chemicals during fetal and neonatal periods can be irreversible and exert effects throughout an animal's entire life. Our previous study showed that neonatal exposure to 17α-ethynyl estradiol (EE) induced irregular estrous cycle in adults. To uncover the reason for the delayed effect after neonatal exposure to EE, reproductive parameters including ovarian weight, ovarian steroidogenesis, and hormonal profiles were investigated in developing female rats...
May 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28502826/recurrent-ovarian-sertoli-leydig-cell-tumor-a-rare-cause-of-secondary-amenorrhea-in-adolescence
#4
Amy M Luke, John W Moroney, Andrea Snitchler, Susan L Whiteway
BACKGROUND: Ovarian tumors, although uncommon in children, can retain endocrine function that disrupts normal feedback mechanisms leading to amenorrhea. Inheritance of germline DICER1 mutations can lead to increased risk for development of ovarian Sertoli-Leydig cell tumors (SLCT). CASE: We report the first case of secondary amenorrhea due to elevated inhibin B levels in an adolescent female with an ovarian SLCT. SUMMARY AND CONCLUSIONS: Ovarian tumors should be included in the differential diagnosis for pediatric patients presenting with menstrual irregularities...
May 11, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28487028/insl3-and-amh-in-patients-with-previously-congenital-or-acquired-undescended-testes
#5
Jocelyn van Brakel, Sabine M P F de Muinck Keizer-Schrama, Frans W J Hazebroek, Gert R Dohle, Frank H de Jong
BACKGROUND: In previous reports no differences in Leydig and Sertoli cell function were found between congenital undescended testis (CUDT) and acquired UDT (AUDT) on the basis of serum levels of LH, testosterone, FSH or inhibin B. This study tried to detect differences in Leydig and Sertoli cell function between CUDT and AUDT using insulin-like peptide 3 (INSL3) and anti-Müllerian hormone (AMH). METHOD: 118 men with a history of UDT (CUDT N=55 (6/55 bilateral), AUDT N=63 (15/63 bilateral)) were investigated...
April 5, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28485778/toxic-effects-of-ketamine-on-reproductive-system-via-disrupting-hypothalamic-pituitary-testicular-axis
#6
L Qi, J-Y Liu, Y-L Zhu, W Liu, S-D Zhang, W-B Liu, J-J Jiang
OBJECTIVE: In this paper, we focused on the toxic effect of ketamine on the reproductive system in male rats and its underlying mechanisms. MATERIALS AND METHODS: Rats were randomly allocated into four groups (n=10), i.e. a control group and 3 ketamine groups (high-dose, mid-dose, low-dose). Animals in the ketamine groups received an intraperitoneal injection of ketamine (20, 40 or 60 mg/kg) every 3 days for 7 times. Control rats were injected with normal saline instead...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28482050/parallel-assessment-of-the-effects-of-bisphenol-a-and-several-of-its-analogs-on-the-adult-human-testis
#7
C Desdoits-Lethimonier, L Lesné, P Gaudriault, D Zalko, J P Antignac, Y Deceuninck, C Platel, N Dejucq-Rainsford, S Mazaud-Guittot, B Jégou
STUDY QUESTION: Are bisphenol A (BPA) and BPA analogs (BPA-A) safe for male human reproductive function? SUMMARY ANSWER: The endocrine function of human testes explants [assessed by measuring testosterone and insulin-like factor 3 (INSL3)] was impacted by exposure of the human adult testis explants to BPA/BPA-A. WHAT IS KNOWN ALREADY: The few epidemiologic studies performed suggest that bisphenols have potential endocrine disruptive properties, but they did not identify clear and direct patterns of endocrine disruption...
May 8, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28460567/human-mesenchymal-stem-cells-partially-reverse-infertility-in-chemotherapy-induced-ovarian-failure
#8
Sara A Mohamed, Shahinaz M Shalaby, Mohamed Abdelaziz, Soumia Brakta, William D Hill, Nahed Ismail, Ayman Al-Hendy
INTRODUCTION: Chemotherapy is the most commonly used modality to treat human cancers; however, in many cases it causes irreversible ovarian failure. In this work, we plan to evaluate the restorative function of human bone marrow mesenchymal stem cells (BMSCs) in a chemotherapy-induced ovarian failure mouse model. METHODS: Acclimatized 4 to 6 week-old female mice (C57BL/6) were assigned randomly to a vehicle-treated control group (group 1), chemotherapy-treated group followed by vehicle alone (group 2), or chemotherapy-treated group followed by stem cell intraovarian injection (group 3)...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28441375/primary-adrenal-angiosarcoma-a-rare-and-potentially-misdiagnosed-tumor
#9
Ariel Grajales-Cruz, Francis Baco-Viera, Ernesto Rive-Mora, Carlos Ramirez-Tanchez, David Tasso, Norma Arroyo-Portela, Elizabeth Calderon, Ilean Joan Padua-Octaviani, William Caceres-Perkins
A man aged 69 years presented with acute right flank pain secondary to a hemorrhagic large adrenal tumor. En bloc resection was performed to repair the inferior vena cava. Immunoperoxidase levels in the tumor were positive for factor VIII and CD31 and negative for S100, protein Melan-A, CD34, synaptophysin, chromogranin, desmin, muscle specific actin, ETFA (EMA), KRT20 (CK20), CDX2, TTF1, LNPEP (PLAP), inhibin, ?-fetoprotein, CD30, hepatocyte paraffin, and aberrant expression of cytokeratin 7 and pankeratin...
April 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28438374/validity-of-self-assessed-sexual-maturation-against-physician-assessments-and-hormone-levels
#10
Jorge E Chavarro, Deborah J Watkins, Myriam C Afeiche, Zhenzhen Zhang, Brisa N Sánchez, David Cantonwine, Adriana Mercado-García, Clara Blank-Goldenberg, John D Meeker, Martha María Téllez-Rojo, Karen E Peterson
OBJECTIVE: To compare self-report and physician assessments of sexual maturation against serum hormone markers to evaluate the hypothesis that the validity of self-assessed sexual maturation is underestimated in traditional validation studies. STUDY DESIGN: We adapted a self-assessment instrument that 248 Mexican children and adolescents, aged 8-13 years, completed. The participants were examined by a trained pediatrician and provided fasting blood samples for measurement of reproductive hormones (eg, testosterone, estradiol, sex hormone-binding globulin, inhibin B) and other hormones (eg, C-peptide, insulin-like growth factor 1, leptin, dehydroepiandrosterone sulfate) known to change during adolescence...
April 21, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28428886/vaccination-with-inhibin-%C3%AE-provides-effective-immunotherapy-against-testicular-stromal-cell-tumors
#11
Robert Aguilar, Justin M Johnson, Patrick Barrett, Vincent K Tuohy
BACKGROUND: Testicular cancer is the most common male neoplasm occurring in men between the ages of 20 and 34. Although germ-line testicular tumors respond favorably to current standard of care, testicular stromal cell (TSC) tumors derived from Sertoli cells or Leydig cells often fail to respond to chemotherapy or radiation therapy and have a 5-year overall survival significantly lower than the more common and more treatable germ line testicular tumors. METHODS: To improve outcomes for TSC cancer, we have developed a therapeutic vaccine targeting inhibin-α, a protein produced by normal Sertoli and Leydig cells of the testes and expressed in the majority of TSC tumors...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28424419/integrated-analysis-of-genes-associated-with-poor-prognosis-of-patients-with-colorectal-cancer-liver-metastasis
#12
Zhenyuan Qian, Guobing Zhang, Guangyuan Song, Ji Shi, Lijie Gong, Yiping Mou, Yong Han
Colorectal cancer (CRC) is one of the most common malignances in the gut. Liver is the most common metastasis site of CRC. This study focuses on the primary CRC and its liver metastasis, aiming to discover several liver metastasis related genes and provide therapeutic candidates. We compared gene expression patterns among the groups of normal colorectal mucosa, primary tumor and the liver metastasis using a CRC gene expression dataset. 84 genes were found to be upregulated in both primary tumor and liver metastases...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28407051/igf1r-expression-in-ovarian-granulosa-cells-is-essential-for-steroidogenesis-follicle-survival-and-fertility-in-female-mice
#13
Sarah C Baumgarten, Marah Armouti, CheMyong Ko, Carlos Stocco
Folliculogenesis is a lengthy process that requires the proliferation and differentiation of granulosa cells (GCs) for preovulatory follicle formation. The most crucial endocrine factor involved in this process is follicle-stimulating hormone (FSH). Interestingly, previous in vitro studies indicated that FSH fails to stimulate GC proliferation in the absence of the insulin-like growth factor 1 receptor (IGF1R). To determine the role of the IGF1R in vivo, female mice with a conditional knockdown of the IGF1R in the GCs were produced and had undetectable levels of IGF1R mRNA and protein in the GCs...
April 12, 2017: Endocrinology
https://www.readbyqxmd.com/read/28397603/masculinization-related-genes-and-cell-mass-structures-during-early-gonadal-differentiation-in-the-african-clawed-frog-xenopus-laevis
#14
Mikako Wada, Kazuko Fujitani, Kei Tamura, Shuuji Mawaribuchi, Yosuke Kamata, Nobuhiko Takamatsu, Michihiko Ito
The African clawed frog Xenopus laevis has a female heterogametic ZZ/ZW-type sex-determining system. We previously discovered a W-linked female sex-determining gene dm-W that is involved in ovary formation, probably through the up-regulation of the estrogen synthesis genes cyp19a1 and foxl2. We also reported that a unique "mass-in-line structure", which disappears from ZZ gonads during early testicular development, might serve as the basis for ovary differentiation in ZW gonads. However, the molecular mechanisms underlying early masculinization are poorly understood...
April 2017: Zoological Science
https://www.readbyqxmd.com/read/28387021/diagnosing-clear-cell-neuroendocrine-tumors-on-cytological-specimens-report-of-two-cases-and-brief-literature-review
#15
Kaila Buckley, Zaibo Li
Although many of the common manifestations of Von Hippel-Lindau (VHL) disease are relatively well known, there is one particular entity which is quite rare, but which appears to show a specific predilection for VHL patients. This entity is clear cell neuroendocrine tumor (NET). It is a difficult diagnosis to make due to its cytomorphologic similarities to other entities, such as metastatic clear cell renal cell carcinoma and paraganglioma, amongst others. These tumors, however, are characteristically positive for neuroendocrine markers such as synaptophysin and chromogranin, as well as cytokeratins...
April 6, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28385888/modeling-and-high-throughput-experimental-data-uncover-the-mechanisms-underlying-fshb-gene-sensitivity-to-gonadotropin-releasing-hormone-pulse-frequency
#16
Estee Stern, Frederique Ruf-Zamojski, Lisa Zalepa-King, Hanna Pincas, Soon Gang Choi, Charles S Peskin, Fernand Hayot, Judith L Turgeon, Stuart C Sealfon
Neuroendocrine control of reproduction by brain-secreted pulses of gonadotropin-releasing hormone (GnRH) represents a longstanding puzzle about extracellular signal decoding mechanisms. GnRH regulates the pituitary gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH), both of which are heterodimers specified by unique β subunits (FSHβ/LHβ). Contrary to Lhb, Fshb gene induction has a preference for low frequency GnRH pulses. To clarify the underlying regulatory mechanisms, we developed three biologically anchored mathematical models: 1) parallel activation of Fshb inhibitory factors (e...
April 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28365908/spinal-adrenal-cortical-adenoma-associated-with-beckwith-wiedemann-syndrome-case-report-and-review-of-the-literature
#17
Javier Giner, Isabel Esteban, Fernando Carceller, Javier Saceda, R M Regojo
PURPOSE: Ectopic adrenal cortical adenoma in the spinal region is extremely rare. The majority of cases of ectopic adrenocortical tissue are found along the path of embryonic migration within the urogenital tract. Beckwith-Wiedemann syndrome (BWS) is a pediatric overgrowth disorder involving a predisposition to tumor development, including adrenal lesions. To date, only eight spinal cases have been reported. This is the third reported case in pediatric population, the first one associated with genetic syndrome and the first benign to recur...
April 1, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28363632/regional-localization-of-activin-%C3%AE-a-activin-%C3%AE-c-follistatin-proliferation-and-apoptosis-in-adult-and-developing-mouse-prostate-ducts
#18
Elspeth Gold, Sylvia Zellhuber-McMillan, Gail Risbridger, Francesco Elia Marino
Activins and inhibins, members of the TGF-β superfamily, are growth and differentiation factors involved in the regulation of several biological processes, including reproduction, development, and fertility. Previous studies have shown that the activin-βA subunit plays a pivotal role in prostate development. Activin-A inhibits branching morphogenesis in the developing prostate, and its expression is associated with increased apoptosis in the adult prostate. Follistatin, a structurally unrelated protein to activins, is an antagonist of activin-A...
January 2017: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/28340932/predicting-first-trimester-pregnancy-outcome-derivation-of-a-multiple-marker-test
#19
Suneeta Senapati, Mary D Sammel, Samantha F Butts, Peter Takacs, Karine Chung, Kurt T Barnhart
OBJECTIVE: To predict first trimester pregnancy outcome using biomarkers in a multicenter cohort. DESIGN: Case-control study. SETTING: Three academic centers. PATIENT(S): Women with pain and bleeding in early pregnancy. INTERVENTION(S): Sera from women who were 5-12 weeks' gestational age with ectopic pregnancy (EP), viable intrauterine pregnancy (IUP), and miscarriage/spontaneous abortion (SAB) was analyzed by ELISA and immunoassay for activin A, inhibin A, P, A Disintegrin And Metalloprotease-12, pregnancy-associated plasma protein A (PAPP-A), pregnancy specific B1-glycoprotein (SP1), placental-like growth factor, vascular endothelial growth factor, glycodelin (Glyc), and hCG...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/28340171/immunohistochemical-approach-to-the-differential-diagnosis-of-meningiomas-and-their-mimics
#20
Camille Boulagnon-Rombi, Clémence Fleury, Caroline Fichel, Sophie Lefour, Aude Marchal Bressenot, Guillaume Gauchotte
The differential diagnosis between meningioma and others tumors can be challenging. This study aimed to evaluate different immunohistochemical markers for the differential diagnosis between meningioma and their morphological mimics. Immunohistochemistry was performed on tissue microarray with antiepithelial membrane antigen (EMA), progesterone receptor, somatostatin receptor 2A (SSTR2A), CD34, STAT6, S100, SOX10, HMB45, MelanA, GFAP, inhibin, and BCL2 antibodies. One hundred and twenty-seven meningiomas, 26 solitary fibrous tumor/hemangiopericytomas (SFT/HPC), 39 schwannomas, 17 hemangioblastomas, 21 melanomas, 9 gliosarcomas, 5 neurofibromas, 9 peripheral primitive neuroectodermal tumors, 7 synovial sarcomas, and 5 malignant peripheral nerve sheath tumors were included in the microarray...
April 1, 2017: Journal of Neuropathology and Experimental Neurology
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