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https://www.readbyqxmd.com/read/28879515/testicular-adrenal-rest-tumors-in-congenital-adrenal-hyperplasia-cross-sectional-study-of-51-croatian-male-patients
#1
Miroslav Dumic, Vlatko Duspara, Zorana Grubic, Sasa Kralik Oguic, Veselin Skrabic, Vesna Kusec
Testicular adrenal rest tumors (TARTs) are common cause of infertility in males with congenital adrenal hyperplasia (CAH). We studied the role of genotype and disease regulation on TART development, their impact on gonadal function, and frequency in 47 21-hydroxylase deficiency (21-OHD) and four 11-hydroxylase deficiency (11-OHD) male patients. Testicular ultrasound (TU), genotype, hormonal measurement in 51, and spermiogram in five patients were performed. TARTs were detected in 14 SW21-OHD and one 11-OHD patient: 1/8 patients aged <7 years (1...
September 6, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28877610/the-tumor-suppressive-role-of-inhibin-%C3%AE-a-in-diffuse-large-b-cell-lymphoma
#2
Lei Jiang, Ting Si, Mei Yu, Xinli Zeng, Herbert C Morse, Ying Lu, Guifang Ouyang, Jeff X Zhou
INHBA (inhibin βA), a subunit of a ligand of the transforming growth factor-β superfamily, is known to play diverse roles in various solid tumors. However, its role in hematologic malignancies remains unexplored. Here, we investigated the function of INHBA in diffuse large B-cell lymphoma (DLBCL). Both mRNA and protein levels of INHBA were significantly downregulated in primary DLBCL tissues, irrespective of germinal center B-cell-like (GCB) or non-GCB subtype, compared to those in benign tonsils. The low level of INHBA in patients with de novo DLBCL was correlated with reduced overall and progression-free survival...
September 7, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28877071/uncommon-localization-of-extrarenal-xp11-2-translocation-associated-renal-cell-carcinoma-rcc-case-report
#3
Jaudah Ahmed Al-Maghrabi, Mohamad Nidal Khabaz
The World Health Organization has recognized Xp11.2 translocation-associated renal cell carcinoma (RCC) as a distinct neoplasm that arises within the kidney. Although many reports of extrarenal carcinoma may be found in the literature, to the best of our knowledge, Xp11 translocation-associated RCC with intact kidneys has not been documented. This report describes a multilobulated right retroperitoneal soft tissue mass (7.9×5.3×12.6 cm) of a 37-year-old man complaining of abdominal pain in the right side...
September 4, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28874163/expression-of-factors-involved-in-apoptosis-and-cell-survival-is-correlated-with-enzymes-synthesizing-lysophosphatidic-acid-and-its-receptors-in-granulosa-cells-originating-from-different-types-of-bovine-ovarian-follicles
#4
Emilia Sinderewicz, Katarzyna Grycmacher, Dorota Boruszewska, Ilona Kowalczyk-Zięba, Joanna Staszkiewicz, Tomasz Ślężak, Izabela Woclawek-Potocka
BACKGROUND: Lysophosphatidic acid (LPA) regulates reproductive processes in the cow. Ovarian granulosa cells play a pivotal role in follicle growth and development. Nevertheless, the role of LPA in the local regulation of granulosa cell function in different follicle categories in the bovine ovary has not been investigated. METHODS: Ovarian follicles were divided into healthy, transitional and atretic categories. The expression levels of AX, PLA2, LPARs and factors involved in apoptosis and cell survival processes in granulosa cells in different types of follicles were measured by real-time PCR...
September 6, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28874128/relationship-of-genetic-causes-and-inhibin-b-in-non-obstructive-azoospermia-spermatogenic-failure
#5
Qing-Jun Chu, Rui Hua, Chen Luo, Qing-Jie Chen, Biao Wu, Song Quan, Yong-Tong Zhu
BACKGROUND: Chromosomal disorders in non obstructive azoospermia (NOA) may have an important influence on spermatogenesis, which may be reflected by the serum inhibin B levels. Till now, few studies have concerned the relationship of genetic causes and inhibin B in NOA. METHODS: In this retrospective study, 322 men with NOA in Center for Reproductive Medicine, Nanfang Hospital, Southern Medical University were collected. The level of follicle stimulating hormone (FSH), inhibin B, Y chromosome microdeletion test (YCMD) and karyotype were measured...
September 6, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28873352/immunophenotypic-comparison-of-testicular-sclerosing-sertoli-cell-tumors-and-sertoli-cell-tumors-not-otherwise-specified
#6
Hector Mesa, Chen Zhang, Juan C Manivel, Thomas M Ulbright
Testicular Sertoli cell tumors (SCT) are rare and most fall into the category of SCT-not otherwise specified (SCT-NOS). Only a few additional types of SCT are recognized. Sclerosing SCT (S-SCT), originally described in 1991, comprises a small fraction of SCTs and was considered a specific entity until the 2016 revision of the World Health Organization classification of non-germ cell tumors, where it was classified as a morphologic variant of SCT-NOS. In a recent study, differences in expression of PAX2/PAX8, inhibin, androgen receptor and S100 protein between SCT-NOS and S-SCT were noted in a small number of cases...
September 2, 2017: Human Pathology
https://www.readbyqxmd.com/read/28855248/role-of-fsh-glycan-structure-in-the-regulation-of-sertoli-cell-inhibin-production
#7
Luz Andreone, Veronica Ambao, Eliana Herminia Pellizzari, Nazareth Loreti, Selva Cigorraga, Stella Campo
Variations in FSH carbohydrate composition and structure are associated with important structural and functional changes in Sertoli cells (SCs) during sexual maturation. The aim of the present study was to investigate the impact of FSH oligosaccharide structure and its interaction with gonadal factors on the regulation of monomeric and dimeric inhibin production at different maturation stages of the Sertoli cell. Recombinant human FSH (rhFSH) glycosylation variants were isolated according to their sialylation degree (AC and BA) and complexity of oligosaccharides (CO and HY)...
August 30, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28853101/the-effect-of-folate-and-folate-plus-zinc-supplementation-on-endocrine-parameters-and-sperm-characteristics-in-sub-fertile-men-a-systematic-review-and-meta-analysis
#8
Morvarid Irani, Malihe Amirian, Ramin Sadeghi, Justine Le Lez, Robab Latifnejad Roudsari
PURPOSE: To evaluate the effect of folate and folate plus zinc supplementation on endocrine parameters and sperm characteristics in sub fertile men. MATERIALS AND METHODS: We conducted a systematic review and meta-analysis. Electronic databases of Medline, Scopus , Google scholar and Persian databases (SID, Iran medex, Magiran, Medlib, Iran doc) were searched from 1966 to December 2016 using a set of relevant keywords including "folate or folic acid AND (infertility, infertile, sterility)"...
August 29, 2017: Urology Journal
https://www.readbyqxmd.com/read/28852860/bilateral-endoscopic-totally-extraperitoneal-tep-inguinal-hernia-repair-does-not-impair-male-fertility
#9
M M Roos, G J Clevers, E J Verleisdonk, P H Davids, C van de Water, R J Spermon, L S Mulder, J P J Burgmans
PURPOSE: Endoscopic totally extraperitoneal (TEP) hernia repair with polypropylene mesh has become a well-established technique. However, since the mesh is placed in close contact with the spermatic cord, mesh-induced inflammation may affect its structures, possibly resulting in impaired fertility. The aim of this observational prospective cohort study was to assess fertility after bilateral endoscopic TEP inguinal hernia repair in male patients. METHODS: Fifty-seven male patients (22-60 years old) with primary, reducible, bilateral inguinal hernias underwent elective bilateral endoscopic TEP hernia repair with use of polypropylene mesh...
August 29, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28846983/indian-propolis-ameliorates-the-mitomycin-c-induced-testicular-toxicity-by-reducing-dna-damage-and-elevating-the-antioxidant-activity
#10
Sandhya Kumari, Guruprasad Nayak, Sonu T Lukose, Sneha Guruprasad Kalthur, Nandini Bhat, Aswathi R Hegde, Srinivas Mutalik, Guruprasad Kalthur, Satish Kumar Adiga
Development of excellent curative therapy for most of the malignancies has resulted in a growing population of cancer survivors who are at increased risk for a variety of health problems including infertility. Therefore, fertility preservation has become an important issue during cancer treatment in recent years. Combination therapy with natural agents such as vitamins, antioxidants, dietary supplements, and plant products are considered as an attractive option to mitigate normal tissue toxicity imparted by chemotherapy...
August 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28839308/molecular-characterisation-of-isoniazid-resistant-clinical-isolates-of-mycobacterium-tuberculosis-from-khyber-pakhtunkhwa-pakistan
#11
Bashir Ahmad, Muhammad Idrees, Kafeel Ahmad, Shumaila Bashir, Saira Jamil
OBJECTIVE: To investigate the frequency of mutations in catalase-peroxidase and inhibin alpha genes in clinical isolates of isoniazid resistant Mycobacterium tuberculosis strains. METHODS: The study was conducted at Provincial Tuberculosis Reference Laboratory, Peshawar, Pakistan, from April 2015 to March 2016, and comprised sputum specimens obtained from patients of different ages. All the isolates were analysed for isoniazid resistance. Thirty resistant isolates were randomly selected for mutation analysis of the hotspot regions of catalase-peroxidase and inhibin alpha genes...
August 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28838639/effect-of-acute-zika-virus-infection-on-sperm-and-virus-clearance-in-body-fluids-a-prospective-observational-study
#12
Guillaume Joguet, Jean-Michel Mansuy, Giulia Matusali, Safouane Hamdi, Marie Walschaerts, Lynda Pavili, Stefanie Guyomard, Nadia Prisant, Pierre Lamarre, Nathalie Dejucq-Rainsford, Christophe Pasquier, Louis Bujan
BACKGROUND: Evidence of human sexual transmission during Zika virus emergence is a matter of concern, particularly in procreation, but to date, kinetics of seminal shedding and the effects of infection on human reproductive function have not been described. To investigate the effects of Zika virus infection on semen and clearance of Zika virus from semen and body fluids, we aimed to study a cohort of Zika virus-infected men. METHODS: This prospective observational study recruited men presenting with acute Zika virus infection at Pointe-à-Pitre University Hospital in Guadeloupe, French Caribbean, where a Zika virus outbreak occurred between April and November, 2016...
August 21, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28838266/recurrence-of-extreme-serum-analytes-in-consecutive-pregnancies-and-association-with-obstetrical-outcomes
#13
Shelly Soni, David A Krantz, Meir Greenberg, Nidhi Vohra, Burton Rochelson
OBJECTIVE: To evaluate if presence of extreme maternal serum biochemical analytes recurs in consecutive pregnancies. We hypothesized that presence of >1 extreme analyte in prior pregnancy is associated with increased risk of adverse pregnancy outcome in subsequent pregnancy. METHODS: Retrospective cohort study of singleton pregnancies evaluated and delivered in 2 consecutive pregnancies (2011-2015). Adverse outcomes were defined as indicated preterm delivery before 37 completed weeks due to preeclampsia, fetal growth restriction or other complications...
September 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28836868/high-expression-of-inhba-is-an-adverse-prognostic-factor-for-de-novo-acute-myeloid-leukemia
#14
Ting Si, Ying Lu, Fenglin Li, Lei Jiang, Renzhi Pei, Jeff X Zhou
Inhibin-β A (INHBA) is a ligand of the transforming growth factor β superfamily and associated with tumorigenesis and tumor progression in solid tumors. In this study, we investigated the expression levels and clinical significance of INHBA in acute myeloid leukemia (AML). The results showed that high expression of INHBA was significantly correlated with elderly age (>60 years) (p = .038), adverse cytogenetic risks (p = .034), negative NPM1 mutation (p = .016), positive FLT3 internal tandem duplications (p = ...
August 24, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28834227/hypoxia-induced-activin-a-diminishes-endothelial-cell-vasculogenic-activity
#15
Stephanie Merfeld-Clauss, Hongyan Lu, Xue Wu, Keith L March, Dmitry O Traktuev
Acute ischaemia causes a significant loss of blood vessels leading to deterioration of organ function. Multiple ischaemic conditions are associated with up-regulation of activin A, but its effect on endothelial cells (EC) in the context of hypoxia is understudied. This study evaluated the role of activin A in vasculogenesis in hypoxia. An in vitro vasculogenesis model, in which EC were cocultured with adipose stromal cells (ASC), was used. Incubation of cocultures at 0.5% oxygen led to decrease in EC survival and vessel density...
August 18, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28819404/activin-b-regulates-adhesion-invasiveness-and-migratory-activities-in-oral-cancer-a-potential-biomarker-for-metastasis
#16
Akihiro Kita, Atsushi Kasamatsu, Dai Nakashima, Yosuke Endo-Sakamoto, Sho Ishida, Toshihiro Shimizu, Yasushi Kimura, Isao Miyamoto, Shusaku Yoshimura, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa
Activin B, a homodimer of inhibin beta b (INHBB), is a multifunctional cytokine belonging to the transforming growth factor-β (TGF-β) family. However, the molecular functions and clinical relevance of activin B have not been determined in oral cancer. We investigated the critical roles of activin B in oral squamous cell carcinoma (OSCC). We performed quantitative reverse transcriptase-polymerase chain reaction, Western blotting, and immunohistochemistry to study INHBB expression in OSCC-derived cell lines and OSCC clinical samples...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28817115/administration-of-follicle-stimulating-hormone-induces-autophagy-via-upregulation-of-hif-1%C3%AE-in-mouse-granulosa-cells
#17
Jilong Zhou, Wang Yao, Chengyu Li, Wangjun Wu, Qifa Li, Honglin Liu
Recent studies reported the important role of autophagy in follicular development. However, the underlying molecular mechanisms remain elusive. In this study, we investigated the effect of follicle-stimulating hormone (FSH) on mouse granulosa cells (MGCs). Results indicated that autophagy was induced by FSH, which is known to be the dominant hormone regulating follicular development and granulosa cell (GC) proliferation. The activation of mammalian target of rapamycin (mTOR), a master regulator of autophagy, was inhibited during the process of MGC autophagy...
August 17, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28814667/adrenergic-mediated-increases-in-inhba-drive-caf-phenotype-and-collagens
#18
Archana S Nagaraja, Robert L Dood, Guillermo Armaiz-Pena, Yu Kang, Sherry Y Wu, Julie K Allen, Nicholas B Jennings, Lingegowda S Mangala, Sunila Pradeep, Yasmin Lyons, Monika Haemmerle, Kshipra M Gharpure, Nouara C Sadaoui, Cristian Rodriguez-Aguayo, Cristina Ivan, Ying Wang, Keith Baggerly, Prahlad Ram, Gabriel Lopez-Berestein, Jinsong Liu, Samuel C Mok, Lorenzo Cohen, Susan K Lutgendorf, Steve W Cole, Anil K Sood
Adrenergic signaling is known to promote tumor growth and metastasis, but the effects on tumor stroma are not well understood. An unbiased bioinformatics approach analyzing tumor samples from patients with known biobehavioral profiles identified a prominent stromal signature associated with cancer-associated fibroblasts (CAFs) in those with a high biobehavioral risk profile (high Center for Epidemiologic Studies Depression Scale [CES-D] score and low social support). In several models of epithelial ovarian cancer, daily restraint stress resulted in significantly increased CAF activation and was abrogated by a nonspecific β-blocker...
August 17, 2017: JCI Insight
https://www.readbyqxmd.com/read/28811645/inhibin-a-and-decorin-secreted-by-human-adult-renal-stem-progenitor-cells-through-the-tlr2-engagement-induce-renal-tubular-cell-regeneration
#19
Fabio Sallustio, Claudia Curci, Alessandra Aloisi, Chiara Cristina Toma, Elisabetta Marulli, Grazia Serino, Sharon Natasha Cox, Giuseppe De Palma, Alessandra Stasi, Chiara Divella, Rosaria Rinaldi, Francesco Paolo Schena
Acute kidney injury (AKI) is a public health problem worldwide. Several therapeutic strategies have been made to accelerate recovery and improve renal survival. Recent studies have shown that human adult renal progenitor cells (ARPCs) participate in kidney repair processes, and may be used as a possible treatment to promote regeneration in acute kidney injury. Here, we show that human tubular ARPCs (tARPCs) protect physically injured or chemically damaged renal proximal tubular epithelial cells (RPTECs) by preventing cisplatin-induced apoptosis and enhancing proliferation of survived cells...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28805353/the-role-of-melatonin-receptor-mtnr1a-in-the-action-of-melatonin-on-bovine-granulosa-cells
#20
Shu-Juan Wang, Wen-Ju Liu, Li-Ke Wang, Xun-Sheng Pang, Li-Guo Yang
Granulosa cells (GCs) play an important role in ovarian follicle growth, development, and follicular atresia. In the present study, we investigated the effects of Melatonin on bovine GCs, and asked if MTNR1A was involved in their response to this indole hormone. Our results indicated that Melatonin inhibited GC apoptosis by up-regulating the expression of BCL2, BCL-XL, GPX4, and SOD1, and down-regulating the expression of BAX, CASP3, and TP53. Moreover, Melatonin modulated bovine GC function by decreasing the expression of INHA, INHBB, FSHR, and TGFBR3, and the abundance of Inhibin β and Activin B, while increasing the expression of LHR, INHBA, and secretion of progesterone by GCs...
August 14, 2017: Molecular Reproduction and Development
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