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https://www.readbyqxmd.com/read/28727617/granulosa-cell-tumors-novel-predictors-of-recurrence-in-early-stage-patients
#1
Sharif Sakr, Eman Abdulfatah, Sumi Thomas, Zaid Al-Wahab, Rafic Beydoun, Robert Morris, Rouba Ali-Fehmi, Sudeshna Bandyopadhyay
Granulosa cell tumors (GCTs) comprise 2% to 5% of ovarian neoplasms, with unpredictable patterns of recurrence. The HER family, GATA4, and SMAD3 genes are reportedly involved in GCT proliferation and apoptosis and may serve as new predictors of recurrence. The aim of the study was to evaluate novel predictors of recurrence in GCT from a large single institution cohort. Patients diagnosed with GCTs (n=125) between 1975 and 2014 were identified. Clinicopathologic parameters were obtained and immunohistochemical evaluation was performed of calretinin, inhibin, HER2, CD56, SMAD3, and GATA4...
May 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28722192/roles-of-fas-fasl-mediated-apoptosis-and-inhibin-b-in-the-testicular-dysfunction-of-rats-with-left-side-varicocele
#2
J Zhang, P P Jin, M Gong, J H Guo, K Fang, Q T Yi, R J Zhu
We investigated the role of the Fas/FasL signalling pathway and inhibin B expression in rats with an experimentally induced left-side varicocele. Forty-five Sprague Dawley (SD) male rats were randomly divided into three groups in average: control group, sham group and experimental group. The expression of inhibin B in the rat left testis was analysed at the mRNA and protein levels by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting respectively. The expressions of Fas, FasL and caspase-3 in the left testis were measured by RT-PCR and immunofluorescence...
July 18, 2017: Andrologia
https://www.readbyqxmd.com/read/28691383/different-origins-of-two-corpora-lutea-recovered-from-a-pregnant-african-elephant-loxodonta-africana
#3
Y Yamamoto, K Nagaoka, Y Kamite, G Watanabe, T Allen, F Stansfield, K Taya
Elephant ovaries contain multiple corpora lutea (CLs) throughout pregnancy. Two CLs (P-1 and P-2) collected from a pregnant African elephant were used to investigate their origin and physiological state in this study. The mRNA expressions of prolactin receptor, CYP11A and inhibin betaB subunit were higher in P-2 than in P-1, while LHCGR and inhibin betaA subunit mRNA were higher in P-1 than in P-2. Protein expression of cleaved caspase-3 was detected in P-1 but not in P-2. These results suggest different origins for the two CLs in this one pregnant elephant, and we also demonstrated the production of bioactive prolactin by the elephant placenta...
July 9, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28684292/the-polymorphic-insertion-of-the-luteinizing-hormone-receptor-inslq-show-a-negative-association-to-lhr-gene-expression-and-to-the-follicular-fluid-hormonal-profile-in-human-small-antral-follicles
#4
T Borgbo, J Chrudimska, M Macek, J V Jeppesen, J A Bøtkjær, S G Kristensen, K T Macklon, E Ernst, L L Hansen, C Yding Andersen
The luteinizing hormone receptor (LHCGR) has a little studied polymorphic 6 bp insertion (rs4539842/insLQ). This study has evaluated the insLQ polymorphism in relation to potential associations with hormonal characteristics of human small antral follicles (hSAFs). In total, 310 hSAFs were collected from 86 women undergoing fertility preservation. Analysis included hormonal profile of 297 follicular fluid (FF) samples and 148 corresponding granulosa cells samples were evaluated by qPCR for selected genes. Significantly reduced and non-detectable mRNA levels of anti-Müllerian hormone receptor II (AMHR2) and LHCGR, respectively, were observed for insLQ/insLQ compared to -/insLQ and the -/- genotypes...
July 3, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28684220/correlation-of-serum-anti-mullerian-hormone-to-follicular-follicle-stimulating-hormone-and-implantation-potential-of-the-ensuing-embryos
#5
Maw-Sheng Lee, Shu-Ling Tzeng, Shun-Fa Yang, Yi-Ping Lin, En-Hui Cheng, Chun-Chia Huang, Yu-Shih Yang, Tsung-Hsien Lee
Serum anti-Mullerian hormone (AMH) is a predictor of the pregnancy outcome in assisted reproductive technology (ART) cycles, particularly for older women. This study attempts to elucidate the effect of serum AMH on follicular hormone profiles and implantation outcome of the ensuing embryos in ART cycles. A total of 412 patients undergoing ART cycles at a private infertility center were included and 780 follicular fluid samples were collected. Levels of follicular hormones, including FSH, LH, inhibin B, AMH, estradiol, progesterone, and androstenedione were measured...
July 3, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28674591/adult-type-granulosa-cell-tumor-of-the-testis-report-of-a-case-and-review-of-literature
#6
REVIEW
Meriem Elbachiri, Amina Taleb, Nora Derrabi, Zineb Bouchbika, Nadia Benchakroun, Hassan Jouhadi, Nezha Tawfiq, Souha Sahraoui, Abdellatif Benider
Granulosa cell tumors is classified into juvenile and adult types and comprise less than 5% of ovarian tumors in women and are much rarer in men which only 45 have been previously reported. We report here a 40-year young man with a left testicular adult type granulosa cell tumor. The tumor measured 5.5X5X4cm; Immunohistochemical stains showed the tumor diffusely positive for inhibin and vimentin. Post operative CT scans shows a lomboaortic lymphnodes treated by four cycles of chemotherapy type BEP (bleomycin, etoposide, cisplatin)...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28670522/co-administration-of-vitamin-e-and-testosterone-attenuates-the-atrazine-induced-toxic-effects-on-sperm-quality-and-testes-in-rats
#7
Hamed Rezaie Agdam, Mazdak Razi, Amir Amniattalab, Hassan Malekinejad, Morteza Molavi
OBJECTIVE: Atrazine (ATZ) as a widely used herbicide is considered as a potent endocrine disrupter which adversely affects reproductive systems in both genders. This study aimed to assess the effects of testosterone (T)- and vitamin E (VitE)- alone and their coadministration on testicular function and sperm parameters after exposure to ATZ in rats. MATERIALS AND METHODS: In this experimental study, the rats (n=30) are assigned into the following 5 groups: control-sham group (n=6) receiving corn oil, ATZ group (n=6) receiving 200 mg/kg ATZ alone, ATZ+VitE group (n=6) receiving 150 mg/kg ATZ+VitE, ATZ+T group (n=6) receiving 400 µg/kg ATZ+T, and ATZ+VitE+T group (n=6) receiving ATZ+VitE+T for 48 consecutive days...
July 2017: Cell Journal
https://www.readbyqxmd.com/read/28652421/clinical-significance-of-inhba-gene-expression-in-patients-with-gastric-cancer-who-receive-curative-resection-followed-by-adjuvant-s-1-chemotherapy
#8
Yusuke Katayama, Takashi Oshima, Kentaro Sakamaki, Toru Aoyama, Tsutomu Sato, Katsuhiko Masudo, Manabu Shiozawa, Takaki Yoshikawa, Yasushi Rino, Toshio Imada, Munetaka Masuda
BACKGROUND: Standard treatment for stage II/III gastric cancer is curative resection followed by adjuvant chemotherapy. However, the five-year survival remains unsatisfactory. Inhibin βA (INHBA) has been reported to be associated with cancer cell proliferation and chemoresistance. PATIENTS AND METHODS: We studied the clinical significance of INHBA gene expression in 134 patients with stage II/III gastric cancer who received adjuvant chemotherapy with S-1. INHBA expression of specimens of cancer tissue and adjacent normal mucosa was measured by quantitative real-time, reverse-transcription polymerase chain reaction (RT-PCR)...
July 2017: In Vivo
https://www.readbyqxmd.com/read/28650599/anti-mullerian-hormone-a-marker-of-upcoming-menopause-or-a-questionable-guesswork
#9
(no author information available yet)
Anti-Müllerian hormone (AMH) is a protein produced by pre-antral and small antral ovarian follicles. It is an acknowledged marker of ovarian reserve and remaining reproductive capacity, commonly used in reproductive medicine. From the third decade of life, AMH serum levels decrease consecutively up to menopause. Since the standardization of commercial assays, novel contributions of that parameter are being observed. Up to date, there is no screening tool for predicting the age of natural menopause (ANM). The following literature review evaluates the utility of AMH measurement in predicting ANM...
May 26, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28641706/delayed-onset-of-puberty-in-male-offspring-from-bisphenol-a-treated-dams-is-followed-by-the-modulation-of-gene-expression-in-the-hypothalamic-pituitary-testis-axis-in-adulthood
#10
Isabela M Oliveira, Renata M Romano, Patricia de Campos, Monica D Cavallin, Claudio A Oliveira, Marco A Romano
Bisphenol A (BPA) is a synthetic endocrine-disrupting chemical of high prevalence in the environment, which may affect the function of the hypothalamic-pituitary-testis (HPT) axis in adult rats. The aim of the present study was to evaluate whether exposure to BPA during hypothalamic sexual differentiation at doses below the reproductive no observable adverse effect level of the World Health Organization causes changes in the regulation of the HPT axis. For this, 0.5 or 5mgkg-1 BPA was injected subcutaneously to the mothers from gestational day 18 to postnatal day (PND) 5...
June 23, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28637469/impact-of-phthalate-and-bpa-exposure-during-in-utero-windows-of-susceptibility-on-reproductive-hormones-and-sexual-maturation-in-peripubertal-males
#11
Deborah J Watkins, Brisa N Sánchez, Martha Maria Téllez-Rojo, Joyce M Lee, Adriana Mercado-García, Clara Blank-Goldenberg, Karen E Peterson, John D Meeker
BACKGROUND: Phthalates and BPA are endocrine disrupting chemicals (EDCs) widely used in consumer products. Evidence suggests that phthalate and BPA exposure alters steroid hormone levels in adults, while in utero exposure has been associated with altered fetal reproductive development in boys. However, the impact of exposure during distinct critical windows of in utero development on hormone concentrations and sexual maturation during the pubertal transition has not been examined. The objective of this study was to assess trimester-specific in utero phthalate and BPA exposure in relation to measures of reproductive development among peripubertal boys in a Mexico City birth cohort...
June 21, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28633616/sclerosing-stromal-tumor-mimicking-a-pregnancy-luteoma-case-report-of-a-diagnostically-challenging-entity-further-complicated-by-the-presence-of-metastatic-signet-ring-cell-carcinoma-from-the-stomach
#12
Meral Uner, Alp Usubutun
Sclerosing stromal tumors of the ovary are very rare. We report the case of a 29-year-old pregnant woman who presented with a history of preterm labor and gestational hypertension. A huge mass measuring 30 cm in greatest dimension was recognized on the right ovary during cesarean section. Signet ring cell infiltration was seen during intraoperative frozen section consultation. She underwent a right salpingo-oophorectomy, and the permanent diagnosis was sclerosing stromal tumor infiltrated by signet ring cells...
June 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28623529/ameliorative-effect-of-omega-3-on-spermatogenesis-testicular-antioxidant-status-and-preimplantation-embryo-development-in-streptozotocin-induced-diabetes-in-rats
#13
Mehdi Khavarimehr, Vahid Nejati, Mazdak Razi, Gholamreza Najafi
PURPOSE: The present study was done to determine the ameliorative effect of polyunsaturated fatty acid omega-3 against experimental diabetes-induced damages on testicular tissue, sperm parameters and preimplantation embryo development in rat model. METHODS: Thirty-two mature male rats were divided into two control and test groups. The experimental diabetes (50 mg kg(-1) streptozotocin, ip) was induced in test group and subdivided into non-treated diabetic, 300 and 600 mg kg(-1) omega-3-treated (orally by gavage) groups...
June 16, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28613385/expanded-conventional-first-trimester-screening
#14
Jonathan B Carmichael, Hsiao-Pin Liu, David Janik, Terrence W Hallahan, Kypros H Nicolaides, David A Krantz
OBJECTIVE: To determine the performance of a five (5) serum marker plus ultrasound screening protocol for T21, T18 and T13. METHOD: Specimens from 331 unaffected, 34 T21, 19 T18 and 8 T13 cases were analyzed for free Beta hCG, PAPP-A, AFP, PlGF and dimeric inhibin A (DIA). Gaussian distributions of MoM values were used to estimate modeled false positive and detection rates. RESULTS: For T21, at a 1/300 risk cut-off, detection rate of screening with all five serum markers along with nuchal translucency and nasal bone was 98% at a 1...
June 14, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28604129/severe-hyperandrogenemia-in-postmenopausal-woman-as-a-presentation-of-ovarian-hyperthecosis-case-report-and-mini-review-of-the-literature
#15
Adam Czyzyk, Justyna Latacz, Dorota Filipowicz, Agnieszka Podfigurna, Rafal Moszynski, Piotr Jasinski, Stefan Sajdak, Michal Gaca, Andrea R Genazzani, Blazej Meczekalski
Ovarian hyperthecosis (OH) is characterized by the presence of abundant luteinized theca cells in ovaries that secret androgen. It typically presents as severe hyperandrogenism and/or virilization in postmenopausal woman. Here we describe a 66-year old woman with presentation of severe hirsutism, alopecia, clitoromegaly and laboratory finding of significantly elevated serum total testosterone concentration and hyperinsulinemia. Performed imaging studies revealed normal sized, homogeneous ovaries, signs of endometrial hypertrophy and normal adrenal glands...
June 11, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28601147/deep-anestrous-mares-under-natural-photoperiod-treated-with-recombinant-equine-fsh-refsh-and-lh-relh-have-fertile-ovulations-and-become-pregnant
#16
Geraldine A Meyers-Brown, Meaghan C Loud, John C Hyland, Janet F Roser
The most common equine breeding practice to decrease the time to the first ovulation of the year is to use artificial lights starting December 1 in the Northern Hemisphere. It can take 60-90 d for this lighting regimen to induce a fertile ovulation. The success rate for pharmaceutical compounds to carry out the same process has been variable. One compound that did induce an early ovulation was recombinant equine follicle stimulating hormone (reFSH), but neither pregnancy nor cyclicity was established in that study...
August 2017: Theriogenology
https://www.readbyqxmd.com/read/28600055/recurrent-female-adnexal-tumor-of-probably-wolffian-origin-a-case-report
#17
Tian Qiu, Yincheng Teng, Jianqian Tong, Wenqi Tao, Liang Xu
OBJECTIVE: Wolffian adnexal tumors (WATs) are rare, and metastasis is uncommon. We present the case of a 53-year-old female with a recurrent WAT. CASE REPORT: The patient presented with abdominal distension, and ultrasound revealed heterogeneous echoes (130 × 93 × 116 mm(3)) around the uterus and ascites. Her cancer antigen 125 (CA125) and CA19-9 levels were elevated. Hysterectomy, bilateral oophorectomy, and tumor resection were performed. The histopathological diagnosis was a WAT...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28598554/reproductive-hormones-and-metabolic-syndrome-in-24-testicular-cancer-survivors-and-their-biological-brothers
#18
M Bandak, N Jørgensen, A Juul, J Lauritsen, M G G Kier, M S Mortensen, P S Oturai, J Mortensen, P Hojman, J W Helge, G Daugaard
Testicular cancer survivors have impaired gonadal function and increased risk of metabolic syndrome when compared to healthy controls. However, because of the fetal etiology of testicular cancer, familial unrelated healthy men might not be an optimal control group. The objective of this study was to clarify if testicular cancer survivors have impaired gonadal function and increased risk of metabolic syndrome when compared to their biological brothers. A cross-sectional study of testicular cancer survivors (ClinicalTrials...
June 9, 2017: Andrology
https://www.readbyqxmd.com/read/28595284/infertility-diagnosis-has-a-significant-impact-on-the-transcriptome-of-developing-blastocysts
#19
Blair R McCallie, Jason C Parks, Darren K Griffin, William B Schoolcraft, Mandy G Katz-Jaffe
STUDY QUESTION: Is the human blastocyst transcriptome associated with infertility diagnosis, specifically: polycystic ovaries (PCO), male factor (MF), and unexplained (UE)? SUMMARY ANSWER: The global blastocyst transcriptome was significantly altered in association with a PCO, MF, and UE infertility diagnosis. WHAT IS KNOWN ALREADY: Infertility diagnosis has an impact on the probability for a successful outcome following an IVF cycle. Limited information is known regarding the relationship between a specific infertility diagnosis and blastocyst transcription during pre-implantation development...
June 8, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28593614/circulating-anti-m%C3%A3-llerian-hormone-amh-associates-with-the-maturity-of-boys-drawings-does-amh-slow-cognitive-development-in-males
#20
Kirstie Morgan, Ted Ruffman, David K Bilkey, Ian S McLennan
PURPOSE: High levels of circulating anti-Müllerian hormone are unique to developing males, but the function of anti-Müllerian hormone in boys is unknown. In mice, anti-Müllerian hormone contributes to the male biases in the brain, but its receptors are present throughout non-sexually dimorphic portions of the brain. In humans, the speed of maturation is the most overt difference between girls and boys. We postulate that this is because anti-Müllerian hormone slows the maturation of the male human brain...
June 7, 2017: Endocrine
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